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https://www.readbyqxmd.com/read/29457411/-effect-of-hip-fracture-at-different-sites-in-elderly-patients-on-prognosis
#1
Cheng Peng, Xiao-Wei Wang, Shao-Guang Li, Zhi Liu, Tian-Sheng Sun, Jian-Zheng Zhang
OBJECTIVE: To determine the effect of site of fracture on the prognosis for patients of elderly hip fracture. METHODS: From January 2012 to December 2014, 667 patients with hip fractures were divided into femoral neck fracture group and intertrochanteric fracture group according to the site of fracture. There were 304 cases of intertrochanteric fracture, including 96 males and 208 females, with an average age of (80.33±7.94) years old. There were 217 cases of femoral neck fracture, including 74 males and 143 females, with an average age of (79...
October 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29456810/minocycline-through-attenuation-of-oxidative-stress-and-inflammatory-response-reduces-the-neuropathic-pain-in-a-rat-model-of-chronic-constriction-injury
#2
Abolfazl Abbaszadeh, Saeideh Darabi, Amin Hasanvand, Hossein Amini-Khoei, Amir Abbasnezhad, Razieh Choghakhori, Asghar Aaliehpour
Objectives: Several lines of evidence showed that minocycline possesses antioxidant and anti-inflammatory properties. This study aimed to demonstrate the effects of minocycline in rats subjected to chronic constriction injury (CCI). Materials and Methods: In this study four groups (n = 6-8) of rats were used as follows: Sham, CCI, CCI + minocycline (MIN) 10 mg/Kg (IP) and CCI + MIN 30 mg/Kg (IP). On days 3, 7, 14, and 21 post-surgery hot-plate, acetone, and von Frey tests were carried out...
February 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29456755/preliminary-results-of-an-anteverting-triple-periacetabular-osteotomy-for-the-treatment-of-hip-instability-in-down-syndrome
#3
D A Maranho, Y-J Kim, K A Williams, E N Novais
Purpose: To investigate the outcomes of an anteverting triple periacetabular osteotomy for the treatment of hip instability in skeletally immature patients with Down syndrome. Methods: We evaluated 16 patients (21 hips) with Down syndrome and hip instability who underwent an anteverting triple periacetabular osteotomy between 2007 and 2016. There were nine females and seven males with an average age of 7.4 years SD 2.0. We assessed the level of hip pain, gait ability and clinical stability at a minimum of one year after surgery...
February 1, 2018: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29453331/a-prospective-cohort-evaluation-of-the-cortisol-response-to-cardiac-surgery-with-occurrence-of-early-postoperative-cognitive-decline
#4
Sandro Glumac, Goran Kardum, Nenad Karanović
BACKGROUND A recent study reported that patients with higher cortisol levels on the 1st postoperative morning after cardiac surgery exhibited an increased risk of early postoperative cognitive decline (POCD). Therefore, we conducted the current study to gain further insight into the stress response to a surgical procedure as a potential risk factor for early POCD after cardiac surgery. MATERIAL AND METHODS This prospective cohort study enrolled 125 patients undergoing elective cardiac surgery with or without cardiopulmonary bypass (CPB)...
February 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29452792/clinical-and-radiological-features-of-spinal-extradural-arachnoid-cysts-valve-like-mechanism-involving-the-nerve-root-fiber-as-a-possible-cause-of-cyst-expansion
#5
Kazuaki Morizane, Shunsuke Fujibayashi, Bungo Otsuki, Takeshi Sakamoto, Ryosuke Tsutsumi, Seiichi Odate, Akira Kusuba, Shuichi Matsuda
BACKGROUND: Although a valve-like mechanism has been proposed for expansion of spinal extradural arachnoid cysts (SEACs), the detailed mechanism remains unclear. Moreover, closure of the communication site is essential during surgery, but the method to identify the communication site remains unclear. The aim of this study was to determine the detailed mechanism of expanding SEACs through retrospective analysis of SEAC cases undergoing surgery and to elucidate the characteristics of the communication sites...
February 13, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29434802/an-investigation-of-the-mechanism-of-dexmedetomidine-in-improving-postoperative-cognitive-dysfunction-from-the-perspectives-of-alleviating-neuronal-mitochondrial-membrane-oxidative-stress-and-electrophysiological-dysfunction
#6
Jie Chen, Na Shen, Xiaohui Duan, Yaning Guo
The aim of this study was to investigate the mechanism of dexmedetomidine in improving postoperative cognitive dysfunction from the perspectives of alleviating neuronal mitochondrial membrane oxidative stress and electrophysiological dysfunction. A total of 120 patients undergoing elective surgery under general anesthesia from June 2013 to May, 2016 were selected as the subjects of the study and randomly divided into the propofol + remifentanil and dexmedetomidine groups. The Rey Auditory Verbal Learning Test (AVLT) and Beck Depression Inventory (BDI) were performed at day 1 before operation and at day 1, 3, 5 and 15 after operation...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434566/assessment-of-platelet-function-in-traumatic-brain-injury-a-retrospective-observational-study-in-the-neuro-critical-care-setting
#7
Caroline Lindblad, Eric Peter Thelin, Michael Nekludov, Arvid Frostell, David W Nelson, Mikael Svensson, Bo-Michael Bellander
Background: Despite seemingly functional coagulation, hemorrhagic lesion progression is a common and devastating condition following traumatic brain injury (TBI), stressing the need for new diagnostic techniques. Multiple electrode aggregometry (MEA) measures platelet function and could aid in coagulopathy assessment following TBI. The aims of this study were to evaluate MEA temporal dynamics, influence of concomitant therapy, and its capabilities to predict lesion progression and clinical outcome in a TBI cohort...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29430489/posterior-cruciate-ligament-current-concepts-review
#8
REVIEW
Santiago Pache, Zachary S Aman, Mitchell Kennedy, Gilberto Yoshinobu Nakama, Gilbert Moatshe, Connor Ziegler, Robert F LaPrade
The posterior cruciate ligament (PCL) is the largest and strongest ligament in the human knee, and the primary posterior stabilizer. Recent anatomy and biomechanical studies have provided an improved understanding of PCL function. PCL injuries are typically combined with other ligamentous, meniscal and chondral injuries. Stress radiography has become an important and validated objective measure in surgical decision making and post-operative assessment. Isolated grade I or II PCL injuries can usually be treated non-operatively...
January 2018: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29427011/self-learning-computers-for-surgical-planning-and-prediction-of-postoperative-alignment
#9
Renaud Lafage, Sébastien Pesenti, Virginie Lafage, Frank J Schwab
PURPOSE: In past decades, the role of sagittal alignment has been widely demonstrated in the setting of spinal conditions. As several parameters can be affected, identifying the driver of the deformity is the cornerstone of a successful treatment approach. Despite the importance of restoring sagittal alignment for optimizing outcome, this task remains challenging. Self-learning computers and optimized algorithms are of great interest in spine surgery as in that they facilitate better planning and prediction of postoperative alignment...
February 9, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29419714/the-impact-of-comorbid-mental-health-disorders-on-complications-following-adult-spinal-deformity-surgery-with-minimum-2-year-surveillance
#10
Bassel G Diebo, Joshua D Lavian, Daniel P Murray, Shian Liu, Neil V Shah, George A Beyer, Frank A Segreto, Lee Bloom, Dennis Vasquez-Montes, Louis M Day, Douglas A Hollern, Samantha R Horn, Qais Naziri, Daniel Cukor, Peter G Passias, Carl B Paulino
STUDY DESIGN: Retrospective analysis OBJECTIVE.: To compare long-term outcomes between patients with and without mental health comorbidities who are undergoing surgery for adult spinal deformity (ASD). SUMMARY OF BACKGROUND DATA: Recent literature reveals that one in three patients admitted for surgical treatment for ASD has comorbid mental health disorder. Currently, impacts of baseline mental health status on long-term outcomes following ASD surgery have not been thoroughly investigated...
February 6, 2018: Spine
https://www.readbyqxmd.com/read/29402275/acute-administration-of-beta-caryophyllene-prevents-endocannabinoid-system-activation-during-transient-common-carotid-artery-occlusion-and-reperfusion
#11
Laura Poddighe, Gianfranca Carta, Maria Pina Serra, Tiziana Melis, Marianna Boi, Sara Lisai, Elisabetta Murru, Laura Muredda, Maria Collu, Sebastiano Banni, Marina Quartu
BACKGROUND: The transient global cerebral hypoperfusion/reperfusion achieved by induction of Bilateral Common Carotid Artery Occlusion followed by Reperfusion (BCCAO/R) has been shown to stimulate early molecular changes that can be easily traced in brain tissue and plasma, and that are indicative of the tissue physiological response to the reperfusion-induced oxidative stress and inflammation. The aim of the present study is to probe the possibility to prevent the molecular changes induced by the BCCAO/R with dietary natural compounds known to possess anti-inflammatory activity, such as the phytocannabinoid beta-caryophyllene (BCP)...
February 5, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29401475/overexpression-of-ubiquitin-carboxyl-terminal-hydrolase-1-uchl1-in-boys-with-cryptorchidism
#12
Dorota Toliczenko-Bernatowicz, Ewa Matuszczak, Marzena Tylicka, Beata Szymańska, Marta Komarowska, Ewa Gorodkiewicz, Wojciech Debek, Adam Hermanowicz
BACKGROUND: The ubiquitin-proteasome system regulate p53, caspase and Bcl-2 family proteins, and is crucial for the degradation of the defective germ cells in testes. Purpose: to evaluate the concentration of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) in the blood plasma of boys with cryptorchidism and if there is any correlation with patient age. METHODS: Patients-50 boys aged 1-4 years (median = 2,4y.) with unilateral cryptorchidism. Exclusion criteria were: previous human chorionic gonadotropin treatment, an abnormal karyotype, endocrine or immunological disorders or any long-term medication...
2018: PloS One
https://www.readbyqxmd.com/read/29401262/novel-insights-by-4d-flow-imaging-on-aortic-flow-physiology-after-valve-sparing-root-replacement-with-or-without-neosinuses
#13
Nicola Galea, Filippo Piatti, Francesco Sturla, Jonathan W Weinsaft, Christopher Lau, Ilaria Chirichilli, Iacopo Carbone, Emiliano Votta, Carlo Catalano, Ruggero De Paulis, Leonard N Girardi, Alberto Redaelli, Mario Gaudino
OBJECTIVES: This study was undertaken to evaluate the flow dynamics in the aortic root after valve-sparing root replacement with and without neosinuses of Valsalva reconstruction, by exploiting the capability of 4D Flow imaging to measure in vivo blood velocity fields and 3D geometric flow patterns. METHODS: Ten patients who underwent valve-sparing root replacement utilizing grafts with neosinuses or straight tube grafts (5 cases each) were evaluated by 4D Flow imaging at a mean of 46...
February 1, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29398871/application-value-of-enhanced-recovery-after-surgery-for-total-laparoscopic-uncut-roux-en-y-gastrojejunostomy-after-distal-gastrectomy
#14
Yi-Feng Zang, Feng-Zhou Li, Zhi-Peng Ji, Yin-Lu Ding
AIM: To evaluate the safety and feasibility of enhanced recovery after surgery (ERAS) for total laparoscopic uncut Roux-en-Y gastrojejunostomy after distal gastrectomy. METHODS: The clinical data of 42 patients who were divided into an ERAS group (n = 20) and a control group (n = 22) were collected. The observed indicators included operation conditions, postoperative clinical indexes, and postoperative serum stress indexes. Measurement data following a normal distribution are presented as mean ± SD and were analyzed by t-test...
January 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29395747/a-preliminary-modeling-investigation-into-the-safe-correction-zone-for-high-tibial-osteotomy
#15
Jennifer Lb Martay, Antony Jr Palmer, Neil K Bangerter, Stuart Clare, A Paul Monk, Cameron P Brown, Andrew J Price
BACKGROUND: High tibial osteotomy (HTO) re-aligns the weight-bearing axis (WBA) of the lower limb. The surgery reduces medial load (reducing pain and slowing progression of cartilage damage) while avoiding overloading the lateral compartment. The optimal correction has not been established. This study investigated how different WBA re-alignments affected load distribution in the knee, to consider the optimal post-surgery re-alignment. METHODS: We collected motion analysis and seven Tesla MRI data from three healthy subjects, and combined this data to create sets of subject-specific finite element models (total=45 models)...
January 21, 2018: Knee
https://www.readbyqxmd.com/read/29393707/kaempferol-attenuates-acute-lung-injury-in-caecal-ligation-and-puncture-model-of-sepsis-in-mice
#16
Dipankar Jyoti Rabha, Thakur Uttam Singh, Soya Rungsung, Tarun Kumar, Subhashree Parida, Madhu Cholenahalli Lingaraju, Avishek Paul, Monalisa Sahoo, Dinesh Kumar
AIM OF THE STUDY: Kaempferol is a flavonoid and important part of the diet. Kaempferol has shown antioxidant, antiinflammatory and antidiabetic activities in various studies. However, protective potential of kaempferol in acute lung injury induced by sepsis and its mechanism remains unclear. The present study was undertaken to evaluate the effect of kaempferol in sepsis-induced acute lung injury in mice and its possible mechanism of action. MATERIALS AND METHODS: Acute lung injury was induced by CLP surgery in mice...
February 2, 2018: Experimental Lung Research
https://www.readbyqxmd.com/read/29391879/combined-acupuncture-and-general-anesthesia-on-immune-and-cognitive-function-in-elderly-patients-following-subtotal-gastrectomy-for-gastric-cancer
#17
Ningke Wang, Yangwen Ou, Wenxiang Qing
This study investigated the effects of acupuncture combined with general anesthesia on postoperative immune and cognitive functions in elderly patients undergoing subtotal gastrectomy. We recruited 96 elderly patients who received anesthesia for subtotal gastrectomy and randomly divided them into control (n=48) and experimental (n=48) groups. The control group received general anesthesia and the experimental group received combined acupuncture and general anesthesia. We measured hemodynamic immediately before and after anesthesia induction, and immune observations before and after surgery...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29385102/preventive-effects-of-resveratrol-on-endocannabinoid-system-and-synaptic-protein-modifications-in-rat-cerebral-cortex-challenged-by-bilateral-common-carotid-artery-occlusion-and-reperfusion
#18
Gianfranca Carta, Laura Poddighe, Maria Pina Serra, Marianna Boi, Tiziana Melis, Sara Lisai, Elisabetta Murru, Laura Muredda, Maria Collu, Sebastiano Banni, Marina Quartu
This study aims to evaluate the putative roles of a single acute dose of resveratrol (RVT) in preventing cerebral oxidative stress induced by bilateral common carotid artery occlusion, followed by reperfusion (BCCAO/R) and to investigate RVT's ability to preserve the neuronal structural integrity. Frontal and temporal-occipital cortices were examined in two groups of adult Wistar rats, sham-operated and submitted to BCCAO/R. In both groups, 6 h before surgery, half the rats were gavage-fed with a single dose of RVT (40 mg/per rat in 300 µL of sunflower oil as the vehicle), while the second half received the vehicle alone...
January 31, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29379737/bipolar-transurethral-enucleation-and-resection-of-the-prostate-whether-it-is-ready-to-supersede-turp
#19
Peng Xu, Abai Xu, Binshen Chen, Shaobo Zheng, Yawen Xu, Hulin Li, Haiyan Shen, Chunxiao Liu
Objective: According to the EAU Guidelines, transurethral resection of the prostate (TURP) has so far still been considered as the gold standard for surgical treatment for patients with obstructing clinical benign prostate hyperplasia (BPH). However, its relatively high rate of complications and postoperative recurrence necessitates further modification and innovation on the surgery technique. We reported the patient outcomes with our technique. Methods: We retrospectively analyzed 52 patients with obstructing clinical BPH who underwent bipolar transurethral enucleation and resection of the prostate (B-TUERP) between March 2015 and September 2015...
January 2018: Asian Journal of Urology
https://www.readbyqxmd.com/read/29374733/patients-with-increased-levels-of-the-oxidative-stress-biomarker-sod1-appear-to-have-diminished-postoperative-pain-after-midline-laparotomy-a-randomised-trial-with-special-reference-to-postoperative-pain-score-nrs
#20
Jari Kärkkäinen, Tuomas Selander, Martin Purdy, Petri Juvonen, Matti Eskelinen
BACKGROUND/AIM: The levels of the oxidative stress biomarker superoxide dismutase (SOD1) in plasma in relation to pain at rest 24 hours after (NRS24) midline laparotomy in patients with rectus sheath block (RSB) analgesia is unknown. PATIENTS AND METHODS: Initially, 56 patients (39 with cancer), each with an intravenous oxycodone pump as patient-controlled analgesia, were randomized to four groups: control group, no RSB (n=12), single-dose (n=16), repeated-dose (n=12) and continuous infusion (n=16) of RSB analgesia...
February 2018: Anticancer Research
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