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https://www.readbyqxmd.com/read/29028082/evaluation-of-the-role-of-8-iso-pgf-levels-at-multiple-sites-during-intracranial-hemorrhage-in-pediatric-patients
#1
B-X Qi, H Yao, L Shang, L-P Sheng, X-C Wang, L Zhu, X-X Zhang, J-P Wang, D-H Fang
OBJECTIVE: The present study was planned to explore the role of 8-isomeric-prostaglandinF2α (8-iso-PGF2α) levels at the multiple sites of cerebrospinal fluid in children with intracranial hemorrhage. PATIENTS AND METHODS: 90 children with intracranial hemorrhage were admitted to Surgery Intensive Care Unit (SICU) of our hospital from January to December 2013 and were selected as study subjects. They were divided into group A (n=30), group B (n=30) and group C (n=30)...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29026131/mechanical-stress-induces-elastic-fibre-disruption-and-cartilage-matrix-increase-in-ligamentum-flavum
#2
Kazunori Hayashi, Akinobu Suzuki, Sayed Abdullah Ahmadi, Hidetomi Terai, Kentaro Yamada, Masatoshi Hoshino, Hiromitsu Toyoda, Shinji Takahashi, Koji Tamai, Shoichiro Ohyama, Akgar Javid, Mohammad Suhrab Rahmani, Maruf Mohammad Hasib, Hiroaki Nakamura
Lumbar spinal stenosis (LSS) is one of the most frequent causes of low back pain and gait disturbance in the elderly. Ligamentum flavum (LF) hypertrophy is the main pathomechanism of LSS, but the reason for its occurrence is not clearly elucidated. In this study, we established a novel animal model of intervertebral mechanical stress concentration and investigated the biological property of the LF. The LF with mechanical stress concentration showed degeneration with elastic fibres disruption and cartilage matrix increase, which are similar to the findings in hypertrophied LF from patients with LSS...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29017653/-effects-of-hmgb1-inhibition-on-endoplasmic-reticulum-stress-after-myocardial-ischemia-reperfusion-injury-in-rats
#3
Lusha E, Jinglong Nan
OBJECTIVE: To investigate the effect of high mobility group protein B1 (HMGB1) inhibition on endoplasmic reticulum stress (ERS) after myocardial ischemia/reperfusion (I/R) in rats. METHODS: Forty male Sprague-Dawley (SD) rats were randomly divided into four groups (n = 10): sham operation group, I/R model group, Gene silencing (HMGB1-siRNA) group, and empty vector (Scrambled-siRNA) group. Coronary blood flow of the rats were ligated for 30 minutes, relaxed the ligament line for 2 hours, to establish I/R injury model; not ligation with the sham operation group...
October 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28992742/the-effect-of-peroneal-muscle-strength-on-functional-outcomes-after-the-modified-brostr%C3%A3-m-procedure-for-chronic-ankle-instability
#4
Byung-Ki Cho, Ji-Kang Park, Seung-Myung Choi, Nelson F SooHoo
BACKGROUND: Although the peroneal muscles are known to be the major dynamic lateral stabilizers of the ankle, little information is available regarding the change in muscle strength and relation with the outcomes after lateral ligament repair surgery. The purpose of this study was to identify the effects of peroneal strength on the validated functional outcome measures after the modified Broström procedure (MBP) for chronic ankle instability. METHODS: Forty-one patients (41 ankles) who underwent MBP using suture anchors were eligible and followed up to 2 years postoperatively...
October 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28990610/effects-of-cyanidin-3-0-glucoside-on-cardiac-structure-and-function-in-an-animal-model-of-myocardial-infarction
#5
Pema Raj, Jason L McCallum, Christopher Kirby, Gurman Grewal, Liping Yu, Jeffrey T Wigle, Thomas Netticadan
Cyanidin 3-0-glucoside (CG) is a polyphenol with potential health benefits. In this study, we investigated, for the first time, the cardioprotective effects of CG in an animal model of myocardial infarction (MI), a major cause of death worldwide. Sham and MI rats were administered CG (10 mg kg(-1) day(-1)) daily for one week prior to surgery, and 8 weeks post-surgery. Echocardiography was performed to assess cardiac structure and function at 4 and 8 weeks. At 4 weeks, MI rats had significantly lower body mass when compared to control rats, and CG administration significantly prevented this decrease...
October 9, 2017: Food & Function
https://www.readbyqxmd.com/read/28987235/effects-of-l-arginine-supplementation-associated-with-continuous-or-interval-aerobic-training-on-chronic-heart-failure-rats
#6
Giovanna Tedesco Barcelos, Douglas Dalcin Rossato, Júlia Luiza Perini, Lucas Pereira Pinheiro, Carol Carvalho, Rodrigo Boemo Jaenisch, Cláudia Ramos Rhoden, Pedro Dal Lago, Ramiro Barcos Nunes
OBJECTIVE: Chronic heart failure (CHF) is related with exercise intolerance and impaired nitric oxide (NO) production, which can lead to several functional capacity alterations. Considering the possible superiority of aerobic interval training compared to continuous training and the capacity of l-arginine to restore the NO pathway, the aim of the present study was to investigate whether these treatments are beneficial to exercise capacity, muscle mass preservation and hemodynamic, inflammatory and oxidative stress parameters in CHF rats...
November 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28980705/empowering-human-cardiac-progenitor-cells-by-p2y14-nucleotide-receptor-overexpression
#7
Farid G Khalafalla, Waqas Kayani, Arwa Kassab, Kelli Ilves, Megan M Monsanto, Roberto Alvarez, Monica Chavarria, Benjamin Norman, Walter P Dembitsky, Mark A Sussman
Autologous cardiac progenitor cell (hCPC) therapy is a promising alternative approach to current inefficient therapies for heart failure (HF). However, ex vivo expansion and pharmacological/genetic modification of hCPCs are necessary interventions to rejuvenate aged/diseased cells and improve their regenerative capacities. This study was designed to assess the potential of improving hCPC functional capacity by targeting P2Y14 purinergic receptor (P2Y14 R), which has been previously reported to induce regenerative and anti-senescence responses in a variety of experimental models...
October 5, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28979690/multifaceted-effects-of-astragaloside-iv-on-promotion-of-random-pattern-skin-flap-survival-in-rats
#8
Renjin Lin, Huanwen Chen, Daniel Callow, Shihen Li, Lei Wang, Shi Li, Long Chen, Jian Ding, Weiyang Gao, Huazi Xu, Jianzhong Kong, Kailiang Zhou
Random pattern skin flap transplantation is frequently applied in plastic and reconstructive surgery, but the distal part of skin flaps often suffers necrosis due to ischemia. Astragaloside IV (AS-IV), a natural saponin purified from Astragalus membranaceus, may have beneficial functions for flap survival. In this study, rats were divided into a control group and an AS-IV treatment group, and underwent surgery using a modified "McFarlane flap" model. After intragastric administration of vehicle control or AS-IV for their respective groups, flap survival area and water content were measured 7 days after surgery...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28975079/comparing-the-effects-of-isoflurane-sufentanil-anesthesia-and-propofol-sufentanil-anesthesia-on-serum-cortisol-levels-in-open-heart-surgery-with-cardiopulmonary-bypass
#9
Abbas Sedighinejad, Vali Imantalab, Ali Mirmansouri, Bahram Naderi Nabi, Masoud Tarbiat, Ali Mohammad Sadeghi, Nassir Nassiri Sheikhani, Mohammad Haghighi, Zahra Sayahe Varag
BACKGROUND: Major surgeries such as open-heart surgery with cardiopulmonary bypass are associated with a complexity of stress response leading to post-operative complications. Studies have confirmed that anesthesia can mitigate the surgically induced stress response. OBJECTIVES: The aim of this study was to compare the effects of propofol and isoflurane, both supplemented with Sufentanil, on the stress response in coronary artery bypass graft surgery with cardiopulmonary bypass, using cortisol as a biochemical marker...
December 2016: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28975077/the-effects-of-dexmedetomidine-administration-on-postoperative-blood-glucose-levels-in-diabetes-mellitus-patients-undergoing-spinal-anesthesia-a-pilot-study
#10
So Hui Yun, Yun Suk Choi
BACKGROUND: Dexmedetomidine (DEX) is an α2-adrenergic receptor agonist with sedative and sympatholytic effects. It inhibits the stress response and insulin secretion. Therefore, postoperative changes to blood glucose levels were investigated when DEX was intraoperatively infused for sedation purposes in diabetic patients under spinal anesthesia. METHODS: Twenty diabetic patients were randomly allocated to two groups (n = 10). Group A patients were infused with DEX at a dose of 0...
December 2016: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28971172/the-use-of-monocyte-to-hdl-ratio-to-predict-postoperative-atrial-fibrillation-after-aortocoronary-bypass-graft-surgery
#11
Ahmet Ilker Tekkesin, Mert Ilker Hayiroglu, Regayip Zehir, Ceyhan Turkkan, Muhammed Keskin, Goksel Cinier, Ahmet Taha Alper
OBJECTIVE: Postoperative atrial fibrillation (POAF) is a frequent and serious complication after aortocoronary bypass graft (ACBG) surgery and one that, unfortunately, increases morbidity and mortality. Postoperative stroke, hemodynamic instability, renal failure, infection, need for inotropic agent and coronary unit are complications caused by POAF. Inflammation and oxidative stress are among several mechanisms that contribute to pathogenesis of POAF. Monocyte to HDL (M/H) ratio is a newly defined parameter of both inflammation and oxidative stress...
2017: Northern Clinics of Istanbul
https://www.readbyqxmd.com/read/28969883/diabetes-remission-after-bariatric-surgery-is-characterized-by-high-glycemic-variability-and-high-oxidative-stress
#12
G Nosso, R Lupoli, G Saldalamacchia, E Griffo, M Cotugno, G Costabile, G Riccardi, B Capaldo
BACKGROUND AND AIM: To evaluate glycemic variability (GV) and oxidative stress in patients who achieved type 2 diabetes (T2DM) remission after bariatric surgery (BS). METHODS AND RESULTS: Twenty-two patients (M/F10/12, age 50 ± 9 years, BMI 31 ± 6 kg/m(2)) who were in remission of T2DM (T2DM remitters) after BS since at least 1 year and 22 age-, sex- and BMI-matched control subjects were studied. Of the BS group, eleven subjects had undergone Roux-en-Y gastric bypass (RYGB) and eleven subjects sleeve gastrectomy (SG)...
July 18, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28969408/evaluation-of-per-operative-cough-stress-test-during-transobturator-mid-urethral-sling-surgery
#13
Abdulmuttalip Simsek, Sinan Levent Kirecci, Goksel Bayar, Kaya Horasanli, Faruk Ozgor, Zafer Gokhan Gurbuz
PURPOSE: Currently, it is unclear how the mesh tension should be adjusted on the transobturator tape surgery (TOT) for improving continence. The aim of this study was to evaluate the effects of per-operative cough stress test on TOT. MATERIALS AND METHODS: Between March 2007 and December 2011, 206 women with SUI were enrolled in this study. Patients were randomly categorized to treatment with TOT (96) or TOT with cough stress test (110). The IIQ-7 and the UDI-6 were used to identify satisfaction level...
October 3, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28969013/low-dose-of-dexmedetomidine-as-an-adjuvant-to-bupivacaine-in-cesarean-surgery-provides-better-intraoperative-somato-visceral-sensory-block-characteristics-and-postoperative-analgesia
#14
Yong-Hong Bi, Xiao-Guang Cui, Rui-Qin Zhang, Chun-Yu Song, Yan-Zhuo Zhang
OBJECT: In this study, we aimed to investigate the beneficial effects of dexmedetomidine on somato-visceral sensory block characteristcs, postoperative analgesia and stress response of intrathecal bupivacaine administration in women undergoing cesarean section, and to find out which dose is better. METHODS: Sixty parturients with the American Society of Anesthesiologists (ASA) physical status I or II were anesthetized with intrathecal bupivacaine(10mg) alone or in combination with dexmedetomidine (3 μg and 5 μg) to undergo cesarean section...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28967725/testicular-and-thyroid-function-as-survival-predictors-in-the-elderly-patient-candidate-to-surgery
#15
Antonio Aversa, Andrea Fabbri
The relationship between testosterone deficiency (TD) syndrome and surgical resilience has a great impact in the modern approach to male elderly patients. There is good evidence that low levels of T are a strong marker for cardiovascular risk; also, TD is frequently associated with increased cardiovascular and all-cause mortality especially in cardiac older frail men. Screening for low T should be mandatory in high risk groups candidate to surgery including those with diabetes, metabolic syndrome and obesity, even though benefits from T-treatment on survival rates are unclear...
July 18, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/28967423/implementation-of-a-novel-portfolio-of-structured-curriculum-aligned-simulation-based-cardiothoracic-surgery-training-courses-evolving-the-delivery-of-surgical-education
#16
Narain Moorjani, Michael Lewis, Rajesh Shah, Sion Barnard, Tim Graham, Sridhar Rathinam
OBJECTIVE: The provision of high-quality cardiothoracic surgical training faces many challenges. This has generated an increased interest in simulation-based learning, which can provide a less stressful environment for deliberate practice. We developed a comprehensive, structured program of knowledge and simulation-based learning aligned to the official cardiothoracic surgery curriculum. METHODS: A portfolio of 10 curriculum-aligned training courses was designed for cardiothoracic surgical trainees during their 6-year training program...
August 24, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28963101/chronic-psychological-stress-accelerates-vascular-senescence-and-impairs-ischemia-induced-neovascularization-the-role-of-dipeptidyl-peptidase-4-glucagon-like-peptide-1-adiponectin-axis
#17
Limei Piao, Guangxian Zhao, Enbo Zhu, Aiko Inoue, Rei Shibata, Yanna Lei, Lina Hu, Chenglin Yu, Guang Yang, Hongxian Wu, Wenhu Xu, Kenji Okumura, Noriyuki Ouchi, Toyoaki Murohara, Masafumi Kuzuya, Xian Wu Cheng
BACKGROUND: Exposure to psychosocial stress is a risk factor for cardiovascular disease, including vascular aging and regeneration. Given that dipeptidyl peptidase-4 (DPP4) regulates several intracellular signaling pathways associated with the glucagon-like peptide-1 (GLP-1) metabolism, we investigated the role of DPP4/GLP-1 axis in vascular senescence and ischemia-induced neovascularization in mice under chronic stress, with a special focus on adiponectin -mediated peroxisome proliferator activated receptor-γ/its co-activator 1α (PGC-1α) activation...
September 28, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28952598/finite-element-simulation-and-additive-manufacturing-of-stiffness-matched-niti-fixation-hardware-for-mandibular-reconstruction-surgery
#18
Ahmadreza Jahadakbar, Narges Shayesteh Moghaddam, Amirhesam Amerinatanzi, David Dean, Haluk E Karaca, Mohammad Elahinia
Process parameters and post-processing heat treatment techniques have been developed to produce both shape memory and superelastic NiTi using Additive Manufacturing. By introducing engineered porosity, the stiffness of NiTi can be tuned to the level closely matching cortical bone. Using additively manufactured porous superelastic NiTi, we have proposed the use of patient-specific, stiffness-matched fixation hardware, for mandible skeletal reconstructive surgery. Currently, Ti-6Al-4V is the most commonly used material for skeletal fixation devices...
December 19, 2016: Bioengineering
https://www.readbyqxmd.com/read/28952484/fixation-release-and-the-bone-bandaid-a-new-bone-fixation-device-paradigm
#19
Narges Shayesteh Moghaddam, Ahmadreza Jahadakbar, Amirhesam Amerinatanzi, Roman Skoracki, Michael Miller, David Dean, Mohammad Elahinia
The current gold standard of care for mandibular segmental defeat reconstruction is the use of Ti-6Al-4V immobilization hardware and fibular double barrel graft. This method is often successful immediately at restoring mandible function, however the highly stiff fixation hardware causes stress shielding of the grafted bone and stress concentration in the fixation device over time which can lead to fixation device failure and revision surgery. The purpose of reconstructive surgery could be to create normal stress trajectories in the mandible following engraftment...
January 22, 2017: Bioengineering
https://www.readbyqxmd.com/read/28948892/clinical-protocol-levels-are-required-in-laboratory-animal-surgery-when-using-medical-devices-experiences-with-ureteral-replacement-surgery-in-goats
#20
Paul K J D de Jonge, Marije Sloff, Heinz P Janke, Barbara B M Kortmann, Robert P E de Gier, Paul J Geutjes, Egbert Oosterwijk, Wout F J Feitz
It is common to test medical devices in large animal studies that are or could also be used in humans. In this short report we describe the use of a ureteral J-stent for the evaluation of biodegradable tubular constructs for tissue reconstruction, and the regeneration of ureters in Saanen goats. Similarly to a previous study in pigs, the ureteral J-stent was blindly inserted until some resistance was met. During evaluation of the goats after three months, perforation of the renal cortex by the stent was observed in four out of seven animals...
October 2017: Laboratory Animals
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