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https://www.readbyqxmd.com/read/29677027/surgery-complications-and-quality-of-life-a-longitudinal-cohort-study-exploring-the-role-of-psychosocial-factors
#1
Stephanie Archer, Anna Pinto, Sabine Vuik, Colin Bicknell, Omar Faiz, Ben Byrne, Maximilian Johnston, Petros Skapinakis, Thanos Athanasiou, Charles Vincent, Ara Darzi
OBJECTIVE: To determine whether psychosocial factors moderate the relationship between surgical complications and quality of life (QoL). BACKGROUND: Patients who experience surgical complications have significantly worse postoperative QoL than patients with an uncomplicated recovery. Psychosocial factors, such as coping style and level of social support influence how people deal with stressful events, but it is unclear whether they affect QoL following a surgical complication...
April 19, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29676814/potential-of-carnosine-a-histamine-precursor-in-rat-model-of-bilateral-common-carotid-artery-occlusion-induced-vascular-dementia
#2
Nidhi Tiwari, Pankaj Bhatia, Amit Kumar, Amteshwar S Jaggi, Nirmal Singh
The present study investigates the potential of Carnosine a histamine precursor, in rat model of bilateral common carotid artery occlusion (BCCAo) induced vascular dementia (VaD). Wistar rats were subjected to BCCAo procedure under anesthesia to induce VaD. The rats were subjected to Morris water-maze (MWM) test (6th day onwards post-surgery). MWM test was employed to assess learning and memory of the animals whereby ELT (escape latency time), TSTQ (time spent in target quadrant) and Path length (distance travelled) taken as important parameters...
April 20, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29673552/fracture-of-cobalt-chrome-fully-coat-beaded-femoral-revision-long-stem-a-clinical-outcomes-study
#3
Chih-Hsiang Chang, Po-Chun Lin, Cheng-Min Shih, Chun-Chieh Chen, Pang-Hsin Hsieh, Hsin-Nung Shih
BACKGROUND: Femoral bone loss during revision total hip arthroplasty poses a challenging problem. Bypass fixation over the diaphysis has achieved clinical success in cases of proximal femoral bone loss. Fracture of cementless, fully bead-coated femoral stem is an uncommon complication. The purpose of this study is to analyze the patients with and without fracture stem and find out the possible risk factors. METHODS: From 2006 to 2012, a total of 251 revision long stems (Zimmer, Warsaw, IN) were implanted...
February 2018: Biomedical Journal
https://www.readbyqxmd.com/read/29672997/sexual-activity-and-quality-of-life-in-japanese-pelvic-organ-prolapse-patients-after-transvaginal-mesh-surgery
#4
Manami Kinjo, Yasukuni Yoshimura, Yasuhide Kitagawa, Takatsugu Okegawa, Kikuo Nutahara
AIM: This study aimed to evaluate sexual activity and quality of life (QOL) after transvaginal mesh (TVM) surgery in Japanese patients with pelvic organ prolapse (POP). The objective cure rate and associated complications were also investigated. METHODS: The cases of patients who underwent TVM surgery were retrospectively analyzed. QOL was assessed using the Prolapse Quality of Life Questionnaire (P-QOL), and sexual function was evaluated using the Female Sexual Function Index (FSFI) before surgery and 12 months after surgery...
April 19, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29670869/pathogenetic-and-prognostic-factors-for-neonatal-gastric-perforation-personal-experience-and-systematic-review-of-the-literature
#5
Chiara Iacusso, Alessandro Boscarelli, Fabio Fusaro, Pietro Bagolan, Francesco Morini
Introduction: Neonatal gastric perforation (NGP) is a rare entity. Our aim was to report our experience and review the recent literature to characterize NGP, describe associated factors, and define prognostic factors. Materials and methods: Retrospective review of all consecutive patients with NGP treated between June 2009 and December 2017 in a third level pediatric hospital. In addition, a systematic review of Medline and Scopus database was performed using a defined strategy...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29667926/proximal-tibia-stress-fracture-with-osteoarthritis-of-knee-radiological-and-functional-analysis-of-one-stage-tka-with-long-stem
#6
Dhanasekaran Soundarrajan, Natesan Rajkumar, Palanisamy Dhanasekararaja, Shanmuganathan Rajasekaran
INTRODUCTION: Proximal tibia stress fractures with knee osteoarthritis pose a challenging situation. We evaluated the radiological and functional outcome of one-stage total knee arthroplasty (TKA) and long stem for patients with varied grades of knee arthritis and proximal tibia stress fractures.  Methods: We analysed 20 patients from April 2012 to March 2017 with proximal tibia stress fractures associated with knee osteoarthritis of varied grades. Out of 20 patients, five were acute fresh fractures...
2018: SICOT-J
https://www.readbyqxmd.com/read/29666861/lactoferrin-preserves-bone-homeostasis-by-regulating-the-rankl-rank-opg-pathway-of-osteoimmunology
#7
Fengjiao Fan, Pujie Shi, Meng Liu, Hui Chen, Maolin Tu, Weihong Lu, Ming Du
Osteoporosis can be classified as an inflammatory disease and the crosstalk between the immune system and bone growth should be considered. The effects of bovine lactoferrin on bone by osteoimmunology were investigated in the present study. Ten week old female BALB/c mice were ovariectomized (OVX) and fed for 12 weeks with a control diet or lactoferrin (2, 20 and 100 mg kg-1 d-1). The results showed that following 12 weeks of treatment after surgery, OVX resulted in bone loss, but treatment with lactoferrin preserved bone homeostasis...
April 18, 2018: Food & Function
https://www.readbyqxmd.com/read/29665309/association-between-operative-technique-and-intrusive-thoughts-on-health-related-quality-of-life-3-years-after-ape-elape-for-rectal-cancer-results-from-a-national-swedish-cohort-with-comparison-with-normative-swedish-data
#8
Mattias Prytz, Anna Ledebo, Eva Angenete, David Bock, Eva Haglind
The aim of this prospective registry-based population study was to investigate the association between QoL 3 years after surgery for rectal cancer and intrusive thoughts and to assess the association with the type of surgery (i.e., APE or ELAPE) in a population-based national cohort. ELAPE has been proposed as a superior surgical technique for distal rectal cancer, but long-term effects on QoL are not known. There are also no studies on the association of negative intrusive thoughts on patients' self-reported Quality of Life following surgery for distal rectal cancer...
April 17, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29662687/efficacy-of-percutaneous-transhepatic-portal-vein-embolization-using-gelatin-sponge-particles-and-metal-coils
#9
Tomohiro Komada, Kojiro Suzuki, Takashi Mizuno, Tomoki Ebata, Masaya Matsushima, Shinji Naganawa, Masato Nagino
Background: Percutaneous transhepatic portal vein embolization (PTPE) can increase the future liver remnant (FLR) volume before extended liver resection; however, there is no current consensus regarding the best embolic material for PTPE. Purpose: To evaluate the efficacy of PTPE using gelatin sponge particles and coils. Material and Methods: The medical records of 136 patients who underwent PTPE using gelatin sponge particles and metal coils were retrospectively reviewed...
April 2018: Acta Radiologica Open
https://www.readbyqxmd.com/read/29662294/application-of-enhanced-recovery-after-gastric-cancer-surgery-an-updated-meta-analysis
#10
Liu-Hua Wang, Ren-Fei Zhu, Cheng Gao, Shou-Lin Wang, Li-Zong Shen
AIM: To provide an updated assessment of the safety and efficacy of enhanced recovery after surgery (ERAS) protocols in elective gastric cancer (GC) surgery. METHODS: PubMed, Medline, EMBASE, World Health Organization International Trial Register, and Cochrane Library were searched up to June 2017 for all available randomized controlled trials (RCTs) comparing ERAS protocols and standard care (SC) in GC surgery. Thirteen RCTs, with a total of 1092 participants, were analyzed in this study, of whom 545 underwent ERAS protocols and 547 received SC treatment...
April 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29660909/the-effect-of-trimetazidine-in-reducing-the-ischemia-reperfusion-injury-in-rat-epigastric-skin-flaps
#11
Laura Petrovics, Tibor Nagy, Peter Hardi, Laura Bognar, Gabor Pavlovics, Gyorgy Tizedes, Ildiko Takacs, Gabor Jancso
BACKGROUND: Ischemia-reperfusion injury may lead to insufficient microcirculation and results in partial flap loss during the free flap surgeries. OBJECTIVE: This study aimed to investigate the effect of trimetazidine (TMZ) on oxidative stress, inflammation and histopathological changes, using the epigastric skin flap model in rats. METHODS: 40 male Wistar rats were used, that were divided into four groups. Control group, non-treated ischemic (I/R)-group and two trimetazidine treated groups (preischemically, postischemically) were established...
April 13, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29655568/luteolin-attenuates-acute-lung-injury-in-experimental-mouse-model-of-sepsis
#12
Soya Rungsung, Thakur Uttam Singh, Dipankar Jyoti Rabha, Tarun Kumar, Madhu Cholenahalli Lingaraju, Subhashree Parida, Avishek Paul, Monalisa Sahoo, Dinesh Kumar
The present investigation was undertaken to assess the result of pretreatment of luteolin in sepsis-induced acute lung injury in mice and its mechanism of action. Luteolin was administered intraperitoneally one hour before caecal ligation and puncture (CLP) surgery in mice. Acute lung injury was assessed by estimation of different parameters like lung edema, protein content, cytokines level, oxidative stress, inducible nitric oxide synthase (iNOS), intercellular adhesion molecule (ICAM)-1 expression and histopathology...
April 11, 2018: Cytokine
https://www.readbyqxmd.com/read/29649092/ascorbic-acid-attenuates-multifidus-muscles-injury-and-atrophy-after-posterior-lumbar-spine-surgery-by-suppressing-inflammation-and-oxidative-stress-in-a-rat-model
#13
Pan Tang, Yu Gu, Jia-Ming Gu, Zi-Ang Xie, Jia-Qi Xu, Xiang-De Zhao, Kang-Mao Huang, Ji-Ying Wang, Xue-Sheng Jiang, Shun-Wu Fan, Zhi-Jun Hu
STUDY DESIGN: A rat model of multifidus muscles injury and atrophy after posterior lumbar spine surgery. OBJECTIVE: We determined the effect of ascorbic acid (AA) on the postoperative multifidus muscles in rat model. SUMMARY OF BACKGROUND DATA: Previous studies show oxidative stress and inflammation are two main molecular mechanisms in multifidus muscle injury and atrophy after posterior lumbar surgery. AA may have a protective effect in postoperative multifidus muscles...
April 11, 2018: Spine
https://www.readbyqxmd.com/read/29630132/effects-of-sevoflurane-or-propofol-combined-with-remifentanil-anesthesia-on-clinical-efficacy-and-stress-response-in-pregnant-women-with-pregnancy-induced-hypertension
#14
L-Q Ren, X-X Sun, Y Guan
OBJECTIVE: To compare the effects of sevoflurane or propofol combined with remifentanil anesthesia on the clinical efficacy and stress response of pregnancy-induced hypertension (PIHS) in cesarean section. PATIENTS AND METHODS: 150 patients with PIHS and treated with cesarean section in our hospital from May 2015 to September 2016 were selected. All patients were randomly divided into sevoflurane-remifentanil group (n=75) and propofol-remifentanil (n=75). The elbow blood of patients in both groups were collected, the levels of Norepinephrine (NE) adrenaline (AD), cortisol and blood glucose in plasma were compared at before anesthesia induction (T0), operation 30 min (T1), end of operation (T2), 2 h after operation (T3), 24 h after operation (T4)...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29629895/oxidative-stress-and-dna-damage-due-to-one-lung-ventilation
#15
Samil Gunay, Abdullah Taskin, Irfan Eser, Saban Yalcin, Funda Yalcin
AIM: One-lung ventilation (OLV) is an anesthesia technique used to provide visualization in thoracoscopic lung surgeries and increase surgical site visibility during operation. In OLV, atelectasis occurs and blood from the lung participates in circulation without receiving oxygen. We designed a prospective study on patients we implemented surgery in order to research whether OLV leads to oxidative stress and DNA damage or not. METHODS: It was taken 5cc blood samples 4 times from these patients in the postoperative preparatory stage (T1), on the 60th minute after the start of OLV (T2), on the 60th minute after the termination of OLV (T3) and 24 hours after surgery (T4)...
2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29627629/hybrid-constructs-for-performing-three-level-hybrid-surgery-a-finite-element-study
#16
Yang Li, Jia Zhu, Zhenhua Liao, Zhenjun Zhang, Weiqiang Liu
This study aimed to systematically investigate the effect of three-level hybrid constructs on the cervical spine biomechanics based on a validated model of the C3-C7 segments. Three hybrid constructs with two U-shaped dynamic cervical implants (DCIs) and one cage were simulated. The three constructs were (1) Cage-U-U (cage implanted at the C3-C4 level and U-shaped DCIs implanted at the C4-C5 and C5-C6 levels), (2) U-Cage-U, and (3) U-U-Cage. Biomechanical parameters including moments, cervical motions, and stresses in the facet and implants were analyzed in flexion and extension...
April 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29616469/racial-disparities-in-obesity-treatment
#17
REVIEW
Angel S Byrd, Alexander T Toth, Fatima Cody Stanford
PURPOSE OF REVIEW: Obesity rates in the USA have reached pandemic levels with one third of the population with obesity in 2015-2016 (39.8% of adults and 18.5% of youth). It is a major public health concern, and it is prudent to understand the factors which contribute. Racial and ethnic disparities are pronounced in both the prevalence and treatment of obesity and must be addressed in the efforts to combat obesity. RECENT FINDINGS: Disparities in prevalence of obesity in racial/ethnic minorities are apparent as early as the preschool years and factors including genetics, diet, physical activity, psychological factors, stress, income, and discrimination, among others, must be taken into consideration...
April 3, 2018: Current Obesity Reports
https://www.readbyqxmd.com/read/29616443/changes-in-the-serum-urate-level-can-predict-the-development-of-parkinsonism-in-the-6-hydroxydopamine-animal-model
#18
Mohammad Reza Sarukhani, Hashem Haghdoost-Yazdi, Gilda Khandan-Chelarci
Epidemiological studies indicate that a higher plasma level of uric acid (UA) associates with the reduced risk of Parkinson's disease (PD). To confirm the role of UA as a biomarker for PD, we evaluated changes in the serum UA level in the 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonism in rat. For this purpose, 6-OHDA was administered in the medial forebrain bundle by stereotaxic surgery. According to the apomorphine-induced rotational test, the increased intensity of behavioral symptoms as a function of time was associated with the further reduction of UA level...
April 3, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29605899/reoperation-and-complications-after-anterior-cervical-discectomy-and-fusion-and-cervical-disc-arthroplasty-a-study-of-52-395-cases
#19
Michael P Kelly, Claire D Eliasberg, Max S Riley, Remi M Ajiboye, Nelson F SooHoo
PURPOSE: The aim of this study was to analyze rates of perioperative complications and subsequent cervical surgeries in patients treated for cervical degenerative disc disease with anterior cervical discectomy and fusion (ACDF) and those treated with artificial cervical disc arthroplasty (ACDA) for up to 5-year follow-up. METHODS: California's Office of Statewide Health Planning and Development discharge database was analyzed for patients aged 18-65 years undergoing single-level ACDF or ACDA between 2003 and 2010...
March 31, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29604277/jip3-deficiency-attenuates-cardiac-hypertrophy-by-suppression-of-jnk-pathway
#20
Qinghua Ma, Yuxiu Liu, Lianghua Chen
Pathological cardiac hypertrophy is a leading cause of morbidity and mortality worldwide; however, our understanding of the molecular mechanisms revealing the disease is still unclear. In the present study, we suggested that c-Jun N-terminal kinase (JNK)-interacting protein 3 (JIP3), involved in various cellular processes, played an essential role in regulating pathological cardiac hypertrophy through in vivo and in vitro studies. JIP3 was highly expressed in human hearts with hypertrophic cardiomyopathy (HCM), and in mouse hypertrophic hearts...
March 28, 2018: Biochemical and Biophysical Research Communications
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