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https://www.readbyqxmd.com/read/28198198/comparative-evaluation-of-pain-stress-neuropeptide-y-acth-and-cortisol-levels-between-a-conventional-postoperative-care-protocol-and-a-fast-track-recovery-program-in-patients-undergoing-major-abdominal-surgery
#1
Maria Kapritsou, Elizabeth D Papathanassoglou, Evangelos Bozas, Dimitrios P Korkolis, Evangelos A Konstantinou, Ioannis Kaklamanos, Margarita Giannakopoulou
BACKGROUND: Fast-track (FT) postoperative protocol in oncological patients after major abdominal surgery reduces complications and length of postoperative stay compared to the conventional (CON) protocol. However, stress and pain responses have not been compared between the two protocols. OBJECTIVES: To compare stress, pain, and related neuropeptidic responses (adrenocorticotropic hormone [ACTH], cortisol, and neuropeptide Y [NPY]) between FT and CON protocols. METHOD: A clinical trial with repeated measurements was conducted (May 2012 to May 2014) with a sample of 63 hepatectomized or pancreatectomized patients randomized into two groups: FT ( n = 29) or CON ( n = 34)...
March 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/28169489/psychological-and-endocrine-factors-and-pain-after-mastectomy
#2
D Nishimura, S Kosugi, Y Onishi, N Ihara, K Wakaizumi, H Nagata, T Yamada, T Suzuki, S Hashiguchi, H Morisaki
BACKGROUND: This prospective study was designed to examine the associations of demographic, clinical, psychological and neuroendocrine factors with acute and chronic post-operative pain following partial mastectomy. METHODS: Sixty-four female patients scheduled for partial mastectomy were enrolled. Pre-operative anxiety/depression was assessed, using the Hospital Anxiety and Depression Scale (HADS). Pre-operative 24-h urinary cortisol levels were measured 2 days before surgery...
February 7, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28118414/copeptin-predicts-mortality-in-critically-ill-patients
#3
Konstantin A Krychtiuk, Maria C Honeder, Max Lenz, Gerald Maurer, Johann Wojta, Gottfried Heinz, Kurt Huber, Walter S Speidl
BACKGROUND: Critically ill patients admitted to a medical intensive care unit exhibit a high mortality rate irrespective of the cause of admission. Besides its role in fluid and electrolyte balance, vasopressin has been described as a stress hormone. Copeptin, the C-terminal portion of provasopressin mirrors vasopressin levels and has been described as a reliable biomarker for the individual's stress level and was associated with outcome in various disease entities. The aim of this study was to analyze whether circulating levels of copeptin at ICU admission are associated with 30-day mortality...
2017: PloS One
https://www.readbyqxmd.com/read/28073036/does-preoperative-oral-carbohydrate-treatment-reduce-the-postoperative-surgical-stress-response-in-lumbar-disc-surgery
#4
Ozlem Korkmaz Dilmen, Ercument Yentur, Yusuf Tunali, Huriye Balci, Mois Bahar
OBJECTIVES: Surgical trauma produces metabolic and hormonal responses, which are characterized by insulin resistance. Due to extension of the preoperative fasting period, which increases the magnitude of postoperative insulin resistance, preoperative oral carbohydrates (POC) have been developed. PATIENTS AND METHODS: This prospective, randomized, controlled study was performed on 43 ASA I-II patients undergoing elective microsurgical lumbar discectomy. The intervention group received oral carbohydrate solution 800mL the night before and 400mL 2h prior to operation...
February 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28067075/perioperative-humoral-stress-response-to-laparoscopic-versus-open-aortobifemoral-bypass-surgery
#5
Anne H Krog, Per M Thorsby, Mehdi Sahba, Erik M Pettersen, Irene Sandven, Jørgen J Jørgensen, Jon O Sundhagen, Syed S H Kazmi
Minimally invasive surgery seems to reduce hormonal stress response to surgery, but has not previously been examined in major abdominal vascular surgery. Aortic cross-clamping time and operation time is known to be longer in the totally laparoscopic aortobifemoral bypass (LABF) as compared to open aortobifemoral bypass (OABF). The main objective of our study was to measure the hormonal stress response during surgery and aortic cross-clamping in patients undergoing a totally laparoscopic versus an open aortobifemoral bypass...
January 9, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28042237/gut-microbiome-surgical-complications-and-probiotics
#6
REVIEW
George Stavrou, Katerina Kotzampassi
The trigger for infectious complications in patients following major abdominal operations is classically attributed to endogenous enteral bacterial translocation, due to the critical condition of the gut. Today, extensive gut microbiome analysis has enabled us to understand that almost all "evidence-based" surgical or medical intervention (antibiotics, bowel preparation, opioids, deprivation of nutrition), in addition to stress-released hormones, could affect the relative abundance and diversity of the enteral microbiome, allowing harmful bacteria to proliferate in the place of depressed beneficial species...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28008373/clinical-factors-disease-parameters-and-molecular-therapies-affecting-osseointegration-of-orthopedic-implants
#7
Hilal Maradit Kremers, Eric A Lewallen, Andre J van Wijnen, David G Lewallen
Total hip and knee arthroplasty are effective interventions for management of end-stage arthritis. Indeed, about 7 million Americans are currently living with artificial hip and knee joints. The majority of these individuals, however, will outlive their implants and require revision surgeries, mostly due to poor implant osseointegration and aseptic loosening. Revisions are potentially avoidable with better management of patient-related risk factors that affect the osseointegration of orthopedic implants. In this review, we summarize the published clinical literature on the role of demographics, biologic factors, comorbidities, medications and aseptic loosening risk...
September 2016: Current Molecular Biology Reports
https://www.readbyqxmd.com/read/27903577/adrenal-cushing-syndrome-with-detectable-acth-from-an-unexpected-source
#8
Thinzar M Lwin, Nehal Galal, Shweta Gera, Jennifer L Marti
Mixed corticomedullary adrenal tumours (MCMT) are rare. We describe the second reported case of a male patient presenting with hypertension and Cushing syndrome with MCMT. A man aged 48 years presented with hypertension and signs of Cushing syndrome. 24-hour urine cortisol was elevated, with detectable adrenocorticotropic hormone (ACTH). A high-dose dexamethasone suppression test indicated an adrenal or ectopic Cushing syndrome. Plasma metanephrines were normal. A 3 cm left adrenal mass was identified without potential ectopic sources of ACTH on imaging...
November 30, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27821836/effects-of-combined-general-epidural-anesthesia-on-hemodynamics-respiratory-function-and-stress-hormone-levels-in-patients-with-ovarian-neoplasm-undergoing-laparoscopy
#9
Qiang Xu, Hao Zhang, Yan-Mei Zhu, Nian-Jun Shi
BACKGROUND The aim of this study was to evaluate the influence of combined general/epidural anesthesia (GEA) on hemodynamics, respiratory function and stress hormone levels in patients with ovarian neoplasm undergoing laparoscopy. MATERIAL AND METHODS A total of 177 patients with ovarian neoplasm (screened by inclusion/exclusion criteria) receiving laparoscopy were divided into groups G (general anesthesia alone), L1.0 (GEA with 1.0% lidocaine), and L1.5 (GEA with 1.5% lidocaine). Hemodynamics, respiratory parameters and stress hormone levels in the 3 groups were recorded and analyzed...
November 8, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27776761/intraoperative-low-frequency-electroacupuncture-under-general-anesthesia-improves-postoperative-recovery-in-a-randomized-trial
#10
RANDOMIZED CONTROLLED TRIAL
Dennis Grech, Zhifeng Li, Patrick Morcillo, Evelyne Kalyoussef, David D Kim, Alex Bekker, Luis Ulloa
Neuronal stimulation improves physiological responses to infection and trauma, but the clinical potential of this strategy is unknown. We hypothesized that transdermal neural stimulation through low-frequency electroacupuncture might control the immune responses to surgical trauma and expedite the postoperative recovery. However, the efficiency of electroacupuncture is questioned due to the placebo effect. Here, electroacupuncture was performed on anesthetized patients to avoid any placebo. This is a prospective double-blinded pilot trial to determine whether intraoperative electroacupuncture on anesthetized patients improves postoperative recovery...
October 2016: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/27769996/estrogen-receptor-antagonism-exacerbates-cardiac-structural-and-functional-remodeling-in-female-rats
#11
M C El Hajj, V K Ninh, E C El Hajj, J M Bradley, J D Gardner
: We have previously demonstrated the cardioprotective effects of ovarian hormones against adverse ventricular remodeling imposed by chronic volume overload. Here, we assess the estrogen receptor dependence of this cardioprotection. Four groups of female rats were studied: sham-operated (Sham), volume overloaded [aortocaval fistula (ACF)], Sham treated with estrogen receptor antagonist ICI 182,780 (Sham + ICI), and ACF treated with ICI. Cardiac function was assessed temporally using echocardiogram, and tissue samples were collected at 5 days and 6 wk postsurgery...
January 1, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27757353/lipedema-a-relatively-common-disease-with-extremely-common-misconceptions
#12
Donald W Buck, Karen L Herbst
Lipedema, or adiposis dolorosa, is a common adipose tissue disorder that is believed to affect nearly 11% of adult women worldwide. It is characterized most commonly by disproportionate adipocyte hypertrophy of the lower extremities, significant tenderness to palpation, and a failure to respond to extreme weight loss modalities. Women with lipedema report a rapid growth of the lipedema subcutaneous adipose tissue in the setting of stress, surgery, and/or hormonal changes. Women with later stages of lipedema have a classic "column leg" appearance, with masses of nodular fat, easy bruising, and pain...
September 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27687921/effects-of-preoperative-carprofen-on-cardio-respiratory-hormonal-and-metabolic-stress-response-in-calves-during-umbilical-surgery-under-isoflurane-inhalation-anaesthesia
#13
I Schulze, E M Poos, H Meyer, A K List, S B R Kaestner, J Rehage
The aim of this study was to examine the effects of preoperative carprofen on the cardiorespiratory, hormonal and metabolic stress response during umbilical surgery under isoflurane anaesthesia combined with local anaesthesia, in calves. A randomised, blinded experimental study was conducted in 24 calves. Carprofen (n = 12; 1.4 mg/kg) or physiological saline solution (controls; n = 12) was administered 1 h prior to surgery. Anaesthesia was induced with xylazine (0.1 mg/kg, IM) and, after the onset of sedation (i...
October 2016: Veterinary Journal
https://www.readbyqxmd.com/read/27676866/evolution-of-the-anteroposterior-laxity-by-gnrb-at-6-9-and-12-months-post-surgical-anterior-cruciate-ligament-reconstruction
#14
Bertrand Semay, Alexandre Rambaud, Rémi Philippot, Pascal Edouard
OBJECTIVE: This study aimed to analyze the evolution of the tibiofemoral anterior laxity during the return to sport after anterior cruciate ligament reconstruction. PATIENTS AND METHODS: Twenty patients (11 women, 9 men) with mean age of 22.4±5.1 years, operated for ACL reconstruction by a hamstring technique, competitors in a pivot-contact sport, were enrolled between September 2014 and March 2016. They were evaluated at 6 (n=20), 9 (n=13) and 12 (n=13) months postoperatively by laximetry to 250N using laximètre GnRB(®) (GenouROB, Laval, France)...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27595615/tips-to-facilitate-a-preoperative-diagnosis-of-adrenal-ganglioneuroma-report-of-a-challenging-experience-and-review-of-the-literature
#15
Delia Proposito, Francesca De Lucia, Alessandra Giannella, Francesca Frangella, Giuseppe Pappalardo, Maria Santangelo, Domenico Magagnano
AIM: Ganglioneuroma (GN) is the most uncommon and the most benign tumor among neuroblastic neoplasms, and in 29.7% of cases it finds in an adrenal gland. Usually asymptomatic, this tumor is detected incidentally in the majority of cases. It is generally challenging to obtain a precise diagnosis of adrenal ganglioneuroma (AGN) before surgery. Misdiagnosis rate of AGN on CT and MRI is 64.7% and clinicians and surgeons are often lacking in knowledge of this rare disease. For this reason, we pointed out the clinical, biochemical, radiologic and pathologic features of AGN in an our experience, with the aim to find out if there are some features able to facilitate a preoperative diagnosis...
February 10, 2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/27579281/the-cortisol-level-and-its-relationship-with-depression-stress-and-anxiety-indices-in-chronic-methamphetamine-dependent-patients-and-normal-individuals-undergoing-inguinal-hernia-surgery
#16
Bijan Pirnia, Fatemeh Givi, Rasool Roshan, Kambiz Pirnia, Ali Akbar Soleimani
BACKGROUND: Stimulants addition and abuse can cause some functional and morphological changes in the normal function of glands and hormones. Methamphetamine as an addictive stimulant drug affects the Hypothalamic- pituitary-adrenal (HPA) axis and consequently makes some changes in the psychological state of the drug users. The present study aims to examine the relationship between plasma levels of cortisol with depression, stress and anxiety symptoms in chronic methamphetamine-dependent patients and normal individuals who have undergone the inguinal hernia surgery...
2016: Medical Journal of the Islamic Republic of Iran
https://www.readbyqxmd.com/read/27547757/comparison-of-tiva-and-desflurane-added-to-a-subanaesthetic-dose-of-propofol-in-patients-undergoing-coronary-artery-bypass-surgery-evaluation-of-haemodynamic-and-stress-hormone-changes
#17
Didem Onk, Tülin Akarsu Ayazoğlu, Oruç Alper Onk, Mehmet Aksüt, Murat Günay, Kultigin Turkmen, Aynur Özensoy, Çiğdem Yazıcı Ersoy, Abdulkadir Çoban
Introduction. Increased levels of stress hormones are associated with mortality in patients undergoing coronary artery bypass grafting (CABG). Aim. To compare total intravenous anaesthesia (TIVA) and desflurane added to a subanaesthetic dose of propofol. Material and Methods. Fifty patients were enrolled in this study. Fentanyl (3-5 mcg/kg/h) was started in both groups. Patients were divided into two groups. The PD group (n = 25) received 1 minimum alveolar concentration (MAC) desflurane anaesthesia in addition to propofol infusion (2-3 mg/kg/h), while P group (n = 25) received propofol infusion (5-6 mg/kg/h) only...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27529317/effect-of-intraoperative-glucose-infusion-on-catabolism-of-adipose-tissue-and-muscle-protein-in-patients-anesthetized-with-remifentanil-in-combination-with-sevoflurane-during-major-surgery-a-randomized-controlled-multicenter-trial
#18
Atsushi Sawada, Yasuhiro Kamada, Haruko Hayashi, Hiromichi Ichinose, Shinzo Sumita, Michiaki Yamakage
BACKGROUND: A harmful effect of stress hormone secretion during surgery is lipolysis and proteolysis to maintain normal blood glucose levels. A well-titrated general anesthetic improves blood glucose control by suppressing secretion of these stress hormones. The aim of this study was to explore the effect of intraoperative glucose infusion on lipolysis and proteolysis in patients undergoing a general anesthetic consisting of sevoflurane and remifentanil during long (>6 hours) major surgery...
October 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27508630/-op-2c-02-endogenous-ouabain-as-a-biomarker-of-heart-failure-and-a-predictor-of-mortality-after-cardiac-surgery
#19
S Pozzoli, M Simonini, E Messaggio, N Casamassima, E Bignami, L Zagato, C Lanzani, P Manunta
OBJECTIVE: Cardiovascular diseases remain the main cause of mortality and morbidity worldwide. The identification of subjects with increased risk of developing new cardiovascular events remains a priority in order to guide treatments and determine individual prognosis. Biomarkers are useful tools that are able to help physicians in decision-making. Our aim is to investigate Endogenous Ouabain (EO), an adrenal stress hormone with hemodynamic effects, as a valuable biomarker of heart failure...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27498309/evaluation-of-the-urinary-microbiota-of-women-with-uncomplicated-stress-urinary-incontinence
#20
Krystal J Thomas-White, Stephanie Kliethermes, Leslie Rickey, Emily S Lukacz, Holly E Richter, Pamela Moalli, Philippe Zimmern, Peggy Norton, John W Kusek, Alan J Wolfe, Linda Brubaker
BACKGROUND: Female urinary microbiota are associated with urgency urinary incontinence and response to medication. The urinary microbiota of women with stress urinary incontinence has not been described. OBJECTIVE: We sought to study the cross-sectional relationships between urinary microbiota features and demographic and clinical characteristics of women undergoing stress urinary incontinence surgery. STUDY DESIGN: Preoperative urine specimens were collected from women without urinary tract infection and were available from 197 women (174 voided, 23 catheterized) enrolled in a multicenter prospective randomized trial, the Value of Urodynamic Evaluation study...
January 2017: American Journal of Obstetrics and Gynecology
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