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https://www.readbyqxmd.com/read/29907831/strontium-ranelate-promotes-odonto-osteogenic-differentiation-mineralization-of-dental-papillae-cells-in-vitro-and-mineralized-tissue-formation-of-the-dental-pulp-in-vivo
#1
Alamuddin Bakhit, Nobuyuki Kawashima, Kentaro Hashimoto, Sonoko Noda, Keisuke Nara, Masashi Kuramoto, Kento Tazawa, Takashi Okiji
This study examined the effects and mechanisms of strontium ranelate (SrRn)-a drug used to treat osteoporosis-on the proliferation and differentiation/mineralization of cloned dental pulp-like cells (mouse dental papillae cells; MDPs). It also determined whether topical application of SrRn to exposed dental pulp tissue promotes the formation of mineralized tissue in vivo. The MDPs were cultured with or without SrRn, and cell proliferation, odonto-/osteoblastic gene expression, mineralized nodule formation, and Akt phosphorylation were evaluated...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29891734/lvp-keratoprosthesis-anatomical-and-functional-outcomes-in-bilateral-end-stage-corneal-blindness
#2
Sayan Basu, Ritu Nagpal, Juan Carlos Serna-Ojeda, Swapnil Bhalekar, Bhupesh Bagga, Virender Sangwan
PURPOSE: To describe the anatomical and functional outcomes of the novel LVP keratoprosthesis (Kpro), developed as an alternative to the modified osteo-odonto keratoprosthesis (MOOKP), in eyes with end-stage corneal blindness where conventional corneal surgeries are contraindicated. METHODS: This prospective case series included 58 eyes of 56 patients (12 children and 44 adults) with severe bilateral keratopathy and completely dry, dermalised ocular surfaces who underwent unilateral LVP Kpro implantation from 2012 to 2016...
June 11, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29876410/rna-sequencing-data-of-notch-ligand-treated-human-dental-pulp-cells
#3
Jeeranan Manokawinchoke, Praphawi Nattasit, Tanutchaporn Thongngam, Prasit Pavasant, Kevin A Tompkins, Hiroshi Egusa, Thanaphum Osathanon
Indirect immobilized ligand has been shown as an effective technique to activate Notch signalling in vitro. The data presented in this article are related to the published article entitled "Indirect immobilized Jagged1 suppresses cell cycle progression and induces odonto/osteogenic differentiation in human dental pulp cells" (Manokawinchoke et al. 2017) [1]. This data article describes gene expression in indirect immobilized Jagged1 treated human dental pulp cells (hDPs) using high throughput RNA sequencing technique...
April 2018: Data in Brief
https://www.readbyqxmd.com/read/29781925/osteo-odonto-keratoprosthesis-in-severe-thermal-and-chemical-injuries
#4
Alfonso Vasquez-Perez, Mehran Zarei-Ghanavati, Venkata Avadhanam, Christopher Liu
PURPOSE: To report the results of osteo-odonto-keratoprosthesis (OOKP) surgery in patients who sustained severe chemical and thermal injuries. METHODS: This is a noncomparative retrospective case series of 14 patients who underwent OOKP surgery between 2001 and 2016 at the Sussex Eye Hospital, Brighton, UK, because of severe chemical and thermal injuries RESULTS:: OOKP surgery was performed in 14 eyes of 14 patients. Eight patients (57%) sustained thermal injuries and 6 patients (43%) chemical injuries...
May 16, 2018: Cornea
https://www.readbyqxmd.com/read/29724887/four-novel-mutations-in-the-alpl-gene-in-chinese-patients-with-odonto-childhood-and-adult-hypophosphatasia
#5
Lijun Xu, Qianqian Pang, Yan Jiang, Ou Wang, Mei Li, Xiaoping Xing, Weibo Xia
Background and purpose: Hypophosphatasiais (HPP) is a rare inherited disorder characterized by defective bone and/or dental mineralization, and decreased serum alkaline phosphatase activity. ALPL , the only gene related with HPP, encodes tissue non-specific alkaline phosphatase (TNSALP). Few studies were carried out in ALPL gene mutations in the Chinese population with HPP. The purpose of this study is to elucidate the clinical and genetic characteristics of HPP in 5 unrelated Chinese families and 2 sporadic patients...
May 3, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29692560/osteo-odonto-keratoprosthesis-innovative-dental-and-ophthalmic-blending
#6
REVIEW
Jaswinder Kaur
Corneal diseases are among the major causes of global blindness, secondary to cataract. osteo-odonto keratoprosthesis (OOKP) is the ideal treatment for patients with end-stage inflammatory corneal diseases where a portion of tooth along with bone is used to support an optical cylinder to restore vision in such patients. OOKP surgery requires multidisciplinary approach involving dentists, ophthalmologists, and radiologists. Very less is known in dentistry about the role of the periodontium in the field of ophthalmology...
April 2018: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/29676302/keratoprosthesis-current-global-scenario-and-a-broad-indian-perspective
#7
REVIEW
Geetha Iyer, Bhaskar Srinivasan, Shweta Agarwal, Deepti Talele, Ekta Rishi, Pukhraj Rishi, Sripriya Krishnamurthy, Lingam Vijaya, Nirmala Subramanian, Shanmugasundaram Somasundaram
Keratoprosthesis (Kpro) forms the last resort for bilateral end-stage corneal blindness. The Boston Type 1 and 2 Kpros, the modified osteo-odonto Kpro and the osteo-Kpro are the more frequently and commonly performed Kpros, and this review attempts to compile the current data available on these Kpros worldwide from large single-center studies and compare the indications and outcomes with Kpros in the Indian scenario. Although the indications have significantly expanded over the years and the complications have reduced with modifications in design and postoperative regimen, these are procedures that require an exclusive setup, and a commitment toward long-term follow-up and post-Kpro care...
May 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29501483/comparison-of-long-term-results-between-osteo-odonto-keratoprosthesis-and-tibial-bone-keratoprosthesis
#8
Victor Charoenrook, Ralph Michael, Maria Fideliz de la Paz, José Temprano, Rafael I Barraquer
PURPOSE: To compare the anatomical and the functional results between osteo-odonto-keratoprosthesis (OOKP) and keratoprosthesis using tibial bone autograft (Tibial bone KPro). METHODS: We reviewed the charts of 258 patients; 145 had OOKP whereas 113 had Tibial bone KPro implanted. Functional success was defined as best corrected visual acuity ≥0.05 on decimal scale and anatomical success as retention of the keratoprosthesis lamina. Kaplan-Meier survival curves were calculated for anatomical and functional survival as well as to estimate the probability of post-op complications...
April 2018: Ocular Surface
https://www.readbyqxmd.com/read/29384216/microrna-hsa-let-7b-suppresses-the-odonto-osteogenic-differentiation-capacity-of-stem-cells-from-apical-papilla-by-targeting-mmp1
#9
Yanqiu Wang, Xiyao Pang, Jintao Wu, Lin Jin, Yan Yu, Romila Gobin, Jinhua Yu
OBJECTIVES: MicroRNA let-7 family acts as the key regulator of the differentiation of mesenchymal stem cells (MSCs). However, the influence of let-7b on biological characteristics of stem cells from apical papilla (SCAPs) is still controversial. MATERIALS AND METHODS: In this study, the expression of hsa-let-7b was obviously downregulated during the osteogenic differentiation of SCAPs. SCAPs were then infected with hsa-let-7b or hsa-let-7b inhibitor lentiviruses...
January 31, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29360619/hypophosphatasia-biochemical-hallmarks-validate-the-expanded-pediatric-clinical-nosology
#10
Michael P Whyte, Stephen P Coburn, Lawrence M Ryan, Karen L Ericson, Fan Zhang
Hypophosphatasia (HPP) is the inborn-error-of-metabolism due to loss-of-function mutation(s) of the ALPL (TNSALP) gene that encodes the tissue non-specific isoenzyme of alkaline phosphatase (TNSALP). TNSALP represents a family of cell-surface phosphohydrolases differing by post-translational modification that is expressed especially in the skeleton, liver, kidney, and developing teeth. Thus, the natural substrates of TNSALP accumulate extracellularly in HPP including inorganic pyrophosphate (PPi), a potent inhibitor of mineralization, and pyridoxal 5'-phosphate (PLP), the principal circulating form of vitamin B6 ...
May 2018: Bone
https://www.readbyqxmd.com/read/29351041/a-new-technique-in-alveolar-cleft-bone-grafting-for-dental-implant-placement-in-patients-with-cleft-lip-and-palate
#11
Vo Van Nhan, Le Van Son, Ta Anh Tuan, Nguyen Tai Son, Trinh Dinh Hai, Le Duc Lanh, Nguyen Manh Ha, Lam Dai Phong
OBJECTIVE: To evaluate 2 iliac corticocancellous-block grafting techniques for dental implant placement in residual alveolar clefts. DESIGN: Nonrandomized prospective clinical trial between March 2010 and December 2014. SETTING: National Hospital of Odonto-Stomatology, Hanoi, Vietnam. PARTICIPANTS: Thirty-two patients (23 female, 9 male; mean age, 21.28 years; range, 16-31 years) with unilateral complete alveolar cleft after reconstructive surgery for cleft lip and palate (CLP)...
February 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29342438/vitreoretinal-complications-and-outcomes-in-92-eyes-undergoing-surgery-for-modified-osteo-odonto-keratoprosthesis-a-10-year-review
#12
Pukhraj Rishi, Ekta Rishi, Vishvesh Agarwal, Sridevi Nair, Geetha Iyer, Bhaskar Srinivasan, Shweta Agarwal
PURPOSE: To analyze vitreoretinal (VR) complications and treatment outcomes in eyes undergoing modified osteo-odonto-keratoprosthesis (OOKP) surgery. DESIGN: Retrospective case series. PARTICIPANTS: All patients who underwent modified OOKP (mOOKP) surgery at a tertiary eye-care center from March 2003 to February 2013 were included. METHODS: Medical records were reviewed for relevant medical history, best-corrected visual acuity (BCVA), slit-lamp examination, ultrasound scan, oral examination findings, and VR complications...
January 13, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29275854/edta-treatment-for-sodium-hypochlorite-treated-dentin-recovers-disturbed-attachment-and-induces-differentiation-of-mouse-dental-papilla-cells
#13
Kentaro Hashimoto, Nobuyuki Kawashima, Shizuko Ichinose, Keisuke Nara, Sonoko Noda, Takashi Okiji
INTRODUCTION: The disturbance of cellular attachment to dentin by sodium hypochlorite (NaOCl) may hamper pulp tissue regeneration. The aims of this study were to examine the recovering effect of EDTA on the attachment/differentiation of stemlike cells and to address the mechanisms of EDTA-induced recovery under the hypothesis that attachment to the exposed dentin matrix and the subsequent activation of integrin/phosphatidylinositol 3-kinase (PI3K) signaling play a crucial role. METHODS: Mouse dental papilla (MDP) cells were cultured on bovine dentin disks treated with NaOCl (0%, 1...
February 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29215714/photobiomodulation-of-mesenchymal-stem-cells-encapsulated-in-an-injectable-rhbmp4-loaded-hydrogel-directs-hard-tissue-bioengineering
#14
Ivana M A Diniz, Ana C O Carreira, Carla R Sipert, Cindi M Uehara, Maria S N Moreira, Laila Freire, Cibele Pelissari, Patrícia M Kossugue, Daniele R de Araújo, Mari C Sogayar, Márcia M Marques
Photobiomodulation (PBM) therapy displays relevant properties for tissue healing and regeneration, which may be of interest for the tissue engineering field. Here, we show that PBM is able to improve cell survival and to interact with recombinant human Bone Morphogenetic Protein 4 (rhBMP4) to direct and accelerate odonto/osteogenic differentiation of dental derived mesenchymal stem cells (MSCs). MSCs were encapsulated in an injectable and thermo-responsive cell carrier (Pluronic® F-127) loaded with rhBMP4 and then photoactivated...
June 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29079051/minced-pulp-as-source-of-pulpal-mesenchymal-stem-cells-with-odontogenic-differentiation-capacity
#15
Zhangrui Liang, Satoshi Kawano, Wei Chen, Moein Seyed Sadrkhani, Chaehwan Lee, Euiseong Kim, Alireza Moshaverinia, Reuben H Kim, Mo K Kang
INTRODUCTION: Pulp tissue regeneration is becoming a reality after discovery of mesenchymal stem cells (MSCs) residing in the pulp tissues through various clinical innovations, although MSC transplantation into the pulp space has met with challenges of in vitro cell expansion and cultures. As a way to circumvent the regulatory and technical complexities of in vitro MSC culture, we investigated the use of minced pulp tissues as a source of pulpal MSCs for tissue regeneration. METHODS: We characterized the phenotype of cells explanted from minced pulp (MP), namely MP-derived MSCs (MP-MSCs), compared with dental pulp stem cells (DPSCs) established from pulp tissues by enzyme digestion...
January 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29030958/association-of-meox2-polymorphism-with-nonsyndromic-cleft-palate-only-in-a-vietnamese-population
#16
Duy L Tran, Hideto Imura, Akihiro Mori, Satoshi Suzuki, Teruyuki Niimi, Maya Ono, Chisato Sakuma, Shinichi Nakahara, Tham T H Nguyen, Phuong T Pham, Viet Hoang, Van T T Tran, Minh D Nguyen, Nagato Natsume
To evaluate the association between the single nucleotide polymorphism (SNP) rs227493 in the MEOX2 gene and nonsyndromic cleft palate only, this research was conducted as a case-control study by comparing a nonsyndromic cleft palate only group with an independent, healthy, and unaffected control group who were both examined by specialists. Based on clinical examination and medical records, we analyzed a total of 570 DNA samples, including 277 cases and 293 controls, which were extracted from dry blood spot samples collected from both the Odonto and Maxillofacial Hospital in Ho Chi Minh City and Nguyen Dinh Chieu Hospital in Ben Tre province, respectively...
October 14, 2017: Congenital Anomalies
https://www.readbyqxmd.com/read/28986711/blockade-of-lgr4-inhibits-proliferation-and-odonto-osteogenic-differentiation-of-stem-cells-from-apical-papillae
#17
Meng Zhou, Shuyu Guo, Lichan Yuan, Yuxin Zhang, Mengnan Zhang, Huimin Chen, Mengting Lu, Jianrong Yang, Junqing Ma
During tooth root development, stem cells from apical papillae (SCAPs) are indispensable, and their abilities of proliferation, migration and odontoblast differentiation are linked to root formation. Leucine-rich repeat-containing GPCR 4 (LGR4) modulates the biological processes of proliferation and differentiation in multiple stem cells. In this study, we showed that LGR4 is expressed in all odontoblast cell lineage cells and Hertwig's epithelial root sheath (HERS) during the mouse root formation in vivo. In vitro we determined that LGR4 is involved in the Wnt/β-catenin signaling pathway regulating proliferation and odonto/osteogenic differentiation of SCAPs...
December 2017: Journal of Molecular Histology
https://www.readbyqxmd.com/read/28881669/genetic-evaluations-of-chinese-patients-with-odontohypophosphatasia-resulting-from-heterozygosity-for-mutations-in-the-tissue-non-specific-alkaline-phosphatase-gene
#18
Jia Wan, Li Zhang, Tang Liu, Yewei Wang
BACKGROUND: Hypophosphatasia is a rare heritable metabolic disorder characterized by defective bone and tooth mineralization accompanied by a deficiency of tissue-non-specific (liver/bone/kidney) isoenzyme of alkaline phosphatase activity, caused by a number of loss-of-function mutations in the alkaline phosphatase liver type gene. We seek to explore the clinical manifestations and identify the mutations associated with the disease in a Chinese odonto- hypophosphatasia family. RESULTS: The proband and his younger brother affected with premature loss of primary teeth at their 2-year-old...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28860516/indirect-immobilized-jagged1-suppresses-cell-cycle-progression-and-induces-odonto-osteogenic-differentiation-in-human-dental-pulp-cells
#19
Jeeranan Manokawinchoke, Praphawi Nattasit, Tanutchaporn Thongngam, Prasit Pavasant, Kevin A Tompkins, Hiroshi Egusa, Thanaphum Osathanon
Notch signaling regulates diverse biological processes in dental pulp tissue. The present study investigated the response of human dental pulp cells (hDPs) to the indirect immobilized Notch ligand Jagged1 in vitro. The indirect immobilized Jagged1 effectively activated Notch signaling in hDPs as confirmed by the upregulation of HES1 and HEY1 expression. Differential gene expression profiling using an RNA sequencing technique revealed that the indirect immobilized Jagged1 upregulated genes were mainly involved in extracellular matrix organization, disease, and signal transduction...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28781092/properties-of-dental-pulp-derived-mesenchymal-stem-cells-and-the-effects-of-culture-conditions
#20
Nobuyuki Kawashima, Sonoko Noda, Mioko Yamamoto, Takashi Okiji
Dental pulp mesenchymal stem cells (DPMSCs) highly express mesenchymal stem cell markers and possess the potential to differentiate into neural cells, osteoblasts, adipocytes, and chondrocytes. Thus, DPMSCs are considered suitable for tissue regeneration. The colony isolation method has commonly been used to collect relatively large amounts of heterogeneous DPMSCs. Homogenous DPMSCs can be isolated by fluorescence-activated cell sorting using antibodies against mesenchymal stem cell markers, although this method yields a limited number of cells...
August 3, 2017: Journal of Endodontics
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