keyword
https://read.qxmd.com/read/38398043/multifunctional-exosomes-derived-from-m2-macrophages-with-enhanced-odontogenesis-neurogenesis-and-angiogenesis-for-regenerative-endodontic-therapy-an-in-vitro-and-in-vivo-investigation
#1
JOURNAL ARTICLE
Yujie Wang, Jing Mao, Yifan Wang, Nan Jiang, Xin Shi
INTRODUCTION: Exosomes derived from M2 macrophages (M2-Exos) exhibit tremendous potential for inducing tissue repair and regeneration. Herein, this study was designed to elucidate the biological roles of M2-Exos in regenerative endodontic therapy (RET) compared with exosomes from M1 macrophages (M1-Exos). METHODS: The internalization of M1-Exos and M2-Exos by dental pulp stem cells (DPSCs) and human umbilical vein endothelial cells (HUVECs) was detected by uptake assay...
February 16, 2024: Biomedicines
https://read.qxmd.com/read/38391267/long-term-outcomes-of-keratoprosthesis-with-biological-haptic-a-review-of-25-years-of-single-center-surgeries
#2
JOURNAL ARTICLE
Maximilian P M Angerer, Julia M Weller, Friedrich E Kruse, Konrad Hille
PURPOSE: To study the outcome of eyes that underwent surgery for keratoprosthesis with a biological haptic, osteo-odonto-keratoprosthesis (OOKP) or tibia keratoprosthesis, by a single surgeon over a time span of more than 25 years. METHODS: One hundred thirty eyes that had received a keratoprosthesis with a biological haptic between 1994 and 2022 by a single surgeon were included in this retrospective analysis. Main outcome parameters were postoperative best corrected visual acuity, postoperative refractive error, postoperative complications, anatomical and functional survival of the prosthesis as well as comparison of subgroups of the 2 different types (OOKP n = 78; tibia keratoprosthesis n = 52) of keratoprostheses, and subgroup analysis of different indications for surgery...
February 23, 2024: Cornea
https://read.qxmd.com/read/38335452/strontium-containing-piezoelectric-biofilm-promotes-dentin-tissue-regeneration
#3
JOURNAL ARTICLE
Jin Li, Xuefeng Zhao, Yang Xia, Xuanyu Qi, Chenghao Jiang, Yuhuan Xiao, Fei Jiang, Xinquan Jiang, Guoliang Yuan
It remains an obstacle to induce the regeneration of hard dentin tissue in clinical settings. To overcome this, a P(VDF-TrFE) piezoelectric film with 2wt% SrCl2 addition is designed. The biofilm shows a high flexibility, a harmonious biocompatibility, and a large piezoelectric d33 coefficient of 14 pC N-1 , all contributing to building an electric microenvironment that favor the recruitment of dental pulp stem cells (DPSCs) and their differentiation into odontoblasts during normal chewing, speaking, etc. On the other hand, the strontium ions can be gradually released from the film, thus promoting DPSC odonto-differentiation...
February 9, 2024: Advanced Materials
https://read.qxmd.com/read/38310522/a-case-report-of-odonto-hypophosphatasia-with-a-novel-variant-in-the-alpl-gene
#4
Yuji Oto, Daiki Suzuki, Tsubasa Morita, Takeshi Inoue, Akihisa Nitta, Nobuyuki Murakami, Yuuka Abe, Yoshinobu Hamada, Tomoyuki Akiyama, Tomoyo Matsubara
OBJECTIVES: Hypophosphatasia (HPP) is a rare skeletal dysplasia caused by variants in the alkaline phosphatase ( ALPL ) gene. More than 400 pathogenic variants of the ALPL gene have been registered in the ALPL gene variant database. Here, we describe the case of a Japanese child with odonto-hypophsphatasia (odonto-HPP) and a novel ALPL variant. CASE PRESENTATION: At the age of 2 years and 1 month, he prematurely lost one deciduous tooth, with the root intact, when he fell and hit his face lightly...
February 5, 2024: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://read.qxmd.com/read/38243590/notch-signaling-regulates-mineralization-via-microrna-modulation-in-dental-pulp-stem-cells
#5
JOURNAL ARTICLE
Promphakkon Kulthanaamondhita, Chatvadee Kornsuthisopon, Ajjima Chansaenroj, Ravipha Suwittayarak, Voraphat Trachoo, Jeeranan Manokawinchoke, Seung-Cheol Lee, Hiroshi Egusa, Jin Man Kim, Thanaphum Osathanon
OBJECTIVES: This study investigated the miRNA expression profile in Notch-activated human dental stem pulp stem cells (DPSCs) and validated the functions of miRNAs in modulating the odonto/osteogenic properties of DPSCs. METHODS: DPSCs were treated with indirect immobilized Jagged1. The miRNA expression profile was examined using NanoString analysis. Bioinformatic analysis was performed, and miRNA expression was validated. Odonto/osteogenic differentiation was examined using alkaline phosphatase staining, Alizarin Red S staining, as well as odonto/osteogenic-related gene and protein expression...
January 19, 2024: Oral Diseases
https://read.qxmd.com/read/38240345/circ-znf236-mediates-stem-cells-from-apical-papilla-differentiation-by-regulating-lgr4-induced-autophagy
#6
JOURNAL ARTICLE
Ya Xiao, Luyao Chen, Yunlong Xu, Ruiyang Yu, Jiamin Lu, Yue Ke, Rong Guo, Tingjie Gu, Haowen Yu, Yuxin Fang, Zehan Li, Jinhua Yu
AIM: Human stem cells from the apical papilla (SCAPs) are an appealing stem cell source for tissue regeneration engineering. Circular RNAs (circRNAs) are known to exert pivotal regulatory functions in various cell differentiation processes, including osteogenesis of mesenchymal stem cells. However, few studies have shown the potential mechanism of circRNAs in the odonto/osteogenic differentiation of SCAPs. Herein, we identified a novel circRNA, circ-ZNF236 (hsa_circ_0000857) and found that it was remarkably upregulated during the SCAPs committed differentiation...
January 19, 2024: International Endodontic Journal
https://read.qxmd.com/read/38183972/dental-professional-s-perspective-regarding-knowledge-awareness-and-attitude-towards-the-importance-of-charting-dental-anomalies-a-cross-sectional-study
#7
JOURNAL ARTICLE
S Gupta, N Sikka, M Kamboj, A Hooda, A Devi, A Narwal
OBJECTIVES: The presence of dental anomalies could play a significant role in the identification of individuals by comparing antemortem and postmortem data. This cross-sectional study aimed to assess the level of knowledge, attitude, and awareness among dental professionals regarding the importance of charting dental anomalies and maintaining dental records. METHODOLOGY: A self-structured questionnaire was e-mailed to dental professionals practicing in India. The responses were recorded, data tabulated, and one-way ANOVA and post hoc tests were applied for analysis...
December 27, 2023: Journal of Forensic Odonto-stomatology
https://read.qxmd.com/read/38183971/reverse-engineering-in-forensic-investigations-a-new-approach-to-bite-mark-analysis
#8
JOURNAL ARTICLE
E Macorano, F Mele, M Calvano, M Leonardelli, S Duma, G De Gabriele, M G Guerra, L M Galantucci, F Introna, V Santoro
The study of bite marks provides crucial elements that contribute towards identifying the biter. In many cases, it assumes importance when bite marks are detected on the body of a victim of violence, but it could also be relevant when the bite marks are seen on food substances at the crime scene. In both circumstances, comparing the bite marks with a suspect's dentition can be decisive in confirming or excluding the culpability. In this case report, a bun (bread roll) with the sign of a bite was found at the crime scene...
December 27, 2023: Journal of Forensic Odonto-stomatology
https://read.qxmd.com/read/38183970/bibliometric-analysis-of-research-on-dental-age-estimation
#9
JOURNAL ARTICLE
S Ponraj, K Ramar, R Sekar, A Kasi
Dental age estimation plays a key role in therapeutic, medicolegal, forensic, and anthropological applications. The purpose of this study is to evaluate the research progress on dental age estimation using bibliometric analysis. Data were gathered from Scopus, Web of Science and PubMed. Keyword co-occurrence analysis, collaboration network analysis, and descriptive analysis of bibliographic data were all completed using VOS viewer and Biblioshiny software. There has been an ongoing but gradual rise in research regarding dental age estimation, with notable increase since 2014...
December 27, 2023: Journal of Forensic Odonto-stomatology
https://read.qxmd.com/read/38183969/accuracy-of-dental-age-estimations-based-on-individual-teeth-and-staging-system-comparisons
#10
JOURNAL ARTICLE
N N AlOtaibi, F A Aldawood, S J AlQahtani
AIM: To investigate whether a specific tooth or teeth provide the most accurate estimation of chronological age (CA), and determine which of the three staging systems studied represents dental development for an individual tooth. METHOD: Data were collected from 400 digital panoramic radiographs of healthy Saudi children aged 6.00-15.99 years. Each permanent tooth on the left side was evaluated to determine its developmental stage and dental age using the methods by Moorrees, Fanning, and Hunt (MFH) (1963), as adapted by Smith (1991), Gleiser and Hunt (1955), and Nicodemo et al...
December 27, 2023: Journal of Forensic Odonto-stomatology
https://read.qxmd.com/read/38183968/radiographic-evaluation-of-secondary-dentin-formation-in-lower-premolars-for-forensic-age-diagnosis-of-18-years-in-a-sample-of-south-indian-adolescents-and-young-adults
#11
JOURNAL ARTICLE
V C Kuncha, V S Kolaparthi, R K Raparthi, B J Tadakamadla, S K Tadakamadla, S B Balla
There has been an increase in the need for alternate methods of dental age assessment, especially for the forensic age diagnosis of the 18th year of life. This is due to the completion of the third molar development before 18 years or the agenesis or therapeutic extractions of the third molars. The present study aimed to verify whether the secondary dentin formation in lower premolars can be used to determine the completion of the 18th year of life in a sample of South Indian adolescents and young adults. For this purpose, 800 orthopantomograms of 400 male and 400 female South Indian subjects aged 14- 22 were evaluated...
December 27, 2023: Journal of Forensic Odonto-stomatology
https://read.qxmd.com/read/38183967/editorial-the-uniqueness-of-the-human-dentition-revisited-a-logical-approach-to-the-current-impasse
#12
JOURNAL ARTICLE
H Bernitz
No abstract text is available yet for this article.
December 27, 2023: Journal of Forensic Odonto-stomatology
https://read.qxmd.com/read/38132408/a-potential-intracanal-medicament-2-hydroxyisocaproic-acid-hica-cytotoxicity-genotoxicity-and-its-effect-on-scap-differentiation
#13
JOURNAL ARTICLE
Cristine Smoczer, Yun K Park, James B Herrington, Mazin A Askar, Sarah Plecha, Eric Krukonis, Susan B Paurazas
Intracanal medicaments with maximal antimicrobial efficacy and minimal damage to resident stem cells are essential for successful regenerative endodontic procedures. 2-Hydroxyisocaproic acid (HICA) could have the attributes of a potential intracanal medicament. This study evaluates its cytotoxicity, genotoxicity, and effects on the odontogenic and osteogenic differentiation of the stem cells of the apical papilla (SCAP). Cytotoxicity and cell viability assays were performed on cells treated for 24, 48, and 72 h with varying concentrations of HICA and compared to the standard intracanal medicament, calcium hydroxide...
November 27, 2023: Dentistry Journal
https://read.qxmd.com/read/37982856/the-challenge-of-hypophosphatasia-diagnosis-in-adults-results-from-the-hpp-international-working-group-literature-surveillance
#14
REVIEW
Maria Luisa Brandi, Aliya A Khan, Eric T Rush, Dalal S Ali, Hatim Al-Alwani, Khulod Almonaei, Farah Alsarraf, Severine Bacrot, Kathryn M Dahir, Karel Dandurand, Chad Deal, Serge Livio Ferrari, Francesca Giusti, Gordon Guyatt, Erin Hatcher, Steven W Ing, Muhammad Kassim Javaid, Sarah Khan, Roland Kocijan, E Michael Lewiecki, Agnes Linglart, Iman M'Hiri, Francesca Marini, Mark E Nunes, Cheryl Rockman-Greenberg, Lothar Seefried, Jill H Simmons, Susan R Starling, Leanne M Ward, Liang Yao, Romina Brignardello-Petersen, Christian Roux
Hypophosphatasia (HPP) is an inborn error of metabolism caused by reduced or absent activity of the tissue non-specific alkaline phosphatase (TNSALP) enzyme, resulting from pathogenic variants in the ALPL gene. Clinical presentation of HPP is highly variable, including lethal and severe forms in neonates and infants, a benign perinatal form, mild forms manifesting in adulthood, and odonto-HPP. Diagnosis of HPP remains a challenge in adults, as signs and symptoms may be mild and non-specific. Disease presentation varies widely; there are no universal signs or symptoms, and the disease often remains underdiagnosed or misdiagnosed, particularly by clinicians who are not familiar with this rare disorder...
November 20, 2023: Osteoporosis International
https://read.qxmd.com/read/37906002/transmucosal-boston-keratoprosthesis-type-ii-in-a-case-of-severe-bilateral-chemical-burn
#15
JOURNAL ARTICLE
Ana Orive Bañuelos, María Fideliz de la Paz, Raquel Feijóo Lera, Alaitz Santamaría Carro, Ainhoa Martínez Grau, Noelia Andollo Victoriano, Jaime Etxebarria Ecenarro
PURPOSE: The purpose of this report was to describe a new alternative surgical technique combining oral mucosa and the Boston Keratoprosthesis type II (BKPro II) in a patient with severe chemical burn. METHODS: We present a case of a 37-year-old man who suffered a severe bilateral chemical burn. Visual acuity was light perception and projection in both eyes. After many surgeries, including eyelid reconstruction, eyelashes electrolysis, and amniotic membrane transplants, he presented a corneal thinning in his right eye that was managed with an autologous oral mucosa graft...
October 31, 2023: Cornea
https://read.qxmd.com/read/37885183/-orodental-phenotype-and-genotype-findings-in-8-chinese-children-with-hypophosphatasia
#16
JOURNAL ARTICLE
X J Li, J M Su, C Zheng, X W Ye, Z F Wu, D W Wu
Objective: To analyze the oral phenotype and gene variation of children with hypophosphatasia (HPP), and explore the genotype-phenotype correlations. Methods: Eight children diagnosed with HPP from January 2008 to January 2023 in Children's Hospital,Zhejiang University School of Medicine were recruited in this study. The pathogenic genes of 5 of them were sequentially analyzed and all of their oral manifestations, laboratory tests and genetic variation types were retrospectively analyzed. Results: A total of 8 children were recruited in the study, 3 males and 5 females, aged from 20 months to 104 months, whose main complaints were premature deciduous tooth loss...
October 26, 2023: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://read.qxmd.com/read/37880693/comparison-of-students-readiness-from-six-health-education-programs-for-interprofessional-learning-in-vietnam-a-cross-sectional-study
#17
JOURNAL ARTICLE
Nguyen Thi Thanh Huyen, Nguyen Minh Tam, Johan Wens, Giannoula Tsakitzidis, Le Van Chi, Le Ho Thi Quynh Anh, Che Thi Len Len, Huynh Van Chuong, Nguyen Vu Quoc Huy, Martin Valcke
BACKGROUND: Interprofessional education (IPE) is expected to help prepare undergraduate health profession students to collaborate with other healthcare professionals in realising quality of care. Studies stress the necessity of students' readiness for interprofessional learning (IPL) in view of designing IPE programs. The present study aims to determine students' IPL-readiness and looks at related differences in students enrolled in different programs and at different phases in their educational program...
October 25, 2023: BMC Medical Education
https://read.qxmd.com/read/37870737/wnt10a-is-required-for-zebrafish-median-fin-fold-maintenance-and-adult-unpaired-fin-metamorphosis
#18
JOURNAL ARTICLE
Erica L Benard, Ismail Küçükaylak, Julia Hatzold, Kilian U W Berendes, Thomas J Carney, Filippo Beleggia, Matthias Hammerschmidt
BACKGROUND: Mutations of human WNT10A are associated with odonto-ectodermal dysplasia syndromes. Here, we present analyses of wnt10a loss-of-function mutants in the zebrafish. RESULTS: wnt10a mutant zebrafish embryos display impaired tooth development and a collapsing median fin fold (MFF). Rescue experiments show that wnt10a is essential for MFF maintenance both during embryogenesis and later metamorphosis. The MFF collapse could not be attributed to increased cell death or altered proliferation rates of MFF cell types...
October 23, 2023: Developmental Dynamics
https://read.qxmd.com/read/37861249/designing-calcium-silicate-cements-with-on-demand-properties-for-precision-endodontics
#19
JOURNAL ARTICLE
A Cahyanto, P Rath, T X Teo, S S Tong, R Malhotra, B N Cavalcanti, L Z Lim, K S Min, D Ho, W F Lu, V Rosa
Calcium silicate (C3S) cements are available in kits that do not account for patients' specific needs or clinicians' preferences regarding setting time, radiopacity, mechanical, and handling properties. Moreover, slight variations in powder components and liquid content affect cement's properties and bioactivity. Unfortunately, it is virtually impossible to optimize several cement properties simultaneously via the traditional "one variable at a time" strategy, as inputs often induce trade-offs in properties (e...
October 20, 2023: Journal of Dental Research
https://read.qxmd.com/read/37754860/comparative-biocompatibility-and-odonto-osteogenesis-effects-of-hydraulic-calcium-silicate-based-cements-in-simulated-direct-and-indirect-approaches-for-regenerative-endodontic-treatments-a-systematic-review
#20
REVIEW
Amir-Ali Yousefi-Koma, Hadi Assadian, Sadra Mohaghegh, Hanieh Nokhbatolfoghahaei
BACKGROUND: Regenerative dentistry is the operation of restoring dental, oral and maxillofacial tissues. Currently, there are no guidelines for the ideal cement/material in regenerative endodontic treatments (RET). Hydraulic calcium silicate-based cements (hCSCs) are currently the material of choice for RET. OBJECTIVES: This systematic review was conducted to gather all of the different direct and indirect approaches of using hCSCs in RET in vitro and in vivo, and to ascertain if there are any superiorities to indirect approaches...
August 29, 2023: Journal of Functional Biomaterials
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