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https://www.readbyqxmd.com/read/29676302/keratoprosthesis-current-global-scenario-and-a-broad-indian-perspective
#1
REVIEW
Geetha Iyer, Bhaskar Srinivasan, Shweta Agarwal, Deepti Talele, Ekta Rishi, Pukhraj Rishi, Sripriya Krishnamurthy, Lingam Vijaya, Nirmala Subramanian, Shanmugasundaram Somasundaram
Keratoprosthesis (Kpro) forms the last resort for bilateral end-stage corneal blindness. The Boston Type 1 and 2 Kpros, the modified osteo-odonto Kpro and the osteo-Kpro are the more frequently and commonly performed Kpros, and this review attempts to compile the current data available on these Kpros worldwide from large single-center studies and compare the indications and outcomes with Kpros in the Indian scenario. Although the indications have significantly expanded over the years and the complications have reduced with modifications in design and postoperative regimen, these are procedures that require an exclusive setup, and a commitment toward long-term follow-up and post-Kpro care...
May 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29501483/comparison-of-long-term-results-between-osteo-odonto-keratoprosthesis-and-tibial-bone-keratoprosthesis
#2
Victor Charoenrook, Ralph Michael, Maria Fideliz de la Paz, José Temprano, Rafael I Barraquer
PURPOSE: To compare the anatomical and the functional results between osteo-odonto-keratoprosthesis (OOKP) and keratoprosthesis using tibial bone autograft (Tibial bone KPro). METHODS: We reviewed the charts of 258 patients; 145 had OOKP whereas 113 had Tibial bone KPro implanted. Functional success was defined as best corrected visual acuity ≥0.05 on decimal scale and anatomical success as retention of the keratoprosthesis lamina. Kaplan-Meier survival curves were calculated for anatomical and functional survival as well as to estimate the probability of post-op complications...
February 28, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29384216/microrna-hsa-let-7b-suppresses-the-odonto-osteogenic-differentiation-capacity-of-stem-cells-from-apical-papilla-by-targeting-mmp1
#3
Yanqiu Wang, Xiyao Pang, Jintao Wu, Lin Jin, Yan Yu, Romila Gobin, Jinhua Yu
OBJECTIVES: MicroRNA let-7 family acts as the key regulator of the differentiation of mesenchymal stem cells (MSCs). However, the influence of let-7b on biological characteristics of stem cells from apical papilla (SCAPs) is still controversial. MATERIALS AND METHODS: In this study, the expression of hsa-let-7b was obviously downregulated during the osteogenic differentiation of SCAPs. SCAPs were then infected with hsa-let-7b or hsa-let-7b inhibitor lentiviruses...
January 31, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29360619/hypophosphatasia-biochemical-hallmarks-validate-the-expanded-pediatric-clinical-nosology
#4
Michael P Whyte, Stephen P Coburn, Lawrence M Ryan, Karen L Ericson, Fan Zhang
Hypophosphatasia (HPP) is the inborn-error-of-metabolism due to loss-of-function mutation(s) of the ALPL (TNSALP) gene that encodes the tissue non-specific isoenzyme of alkaline phosphatase (TNSALP). TNSALP represents a family of cell-surface phosphohydrolases differing by post-translational modification that is expressed especially in the skeleton, liver, kidney, and developing teeth. Thus, the natural substrates of TNSALP accumulate extracellularly in HPP including inorganic pyrophosphate (PPi), a potent inhibitor of mineralization, and pyridoxal 5'-phosphate (PLP), the principal circulating form of vitamin B6 ...
May 2018: Bone
https://www.readbyqxmd.com/read/29351041/a-new-technique-in-alveolar-cleft-bone-grafting-for-dental-implant-placement-in-patients-with-cleft-lip-and-palate
#5
Vo Van Nhan, Le Van Son, Ta Anh Tuan, Nguyen Tai Son, Trinh Dinh Hai, Le Duc Lanh, Nguyen Manh Ha, Lam Dai Phong
OBJECTIVE: To evaluate 2 iliac corticocancellous-block grafting techniques for dental implant placement in residual alveolar clefts. DESIGN: Nonrandomized prospective clinical trial between March 2010 and December 2014. SETTING: National Hospital of Odonto-Stomatology, Hanoi, Vietnam. PARTICIPANTS: Thirty-two patients (23 female, 9 male; mean age, 21.28 years; range, 16-31 years) with unilateral complete alveolar cleft after reconstructive surgery for cleft lip and palate (CLP)...
February 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29342438/vitreoretinal-complications-and-outcomes-in-92-eyes-undergoing-surgery-for-modified-osteo-odonto-keratoprosthesis-a-10-year-review
#6
Pukhraj Rishi, Ekta Rishi, Vishvesh Agarwal, Sridevi Nair, Geetha Iyer, Bhaskar Srinivasan, Shweta Agarwal
PURPOSE: To analyze vitreoretinal (VR) complications and treatment outcomes in eyes undergoing modified osteo-odonto-keratoprosthesis (OOKP) surgery. DESIGN: Retrospective case series. PARTICIPANTS: All patients who underwent modified OOKP (mOOKP) surgery at a tertiary eye-care center from March 2003 to February 2013 were included. METHODS: Medical records were reviewed for relevant medical history, best-corrected visual acuity (BCVA), slit-lamp examination, ultrasound scan, oral examination findings, and VR complications...
January 13, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29275854/edta-treatment-for-sodium-hypochlorite-treated-dentin-recovers-disturbed-attachment-and-induces-differentiation-of-mouse-dental-papilla-cells
#7
Kentaro Hashimoto, Nobuyuki Kawashima, Shizuko Ichinose, Keisuke Nara, Sonoko Noda, Takashi Okiji
INTRODUCTION: The disturbance of cellular attachment to dentin by sodium hypochlorite (NaOCl) may hamper pulp tissue regeneration. The aims of this study were to examine the recovering effect of EDTA on the attachment/differentiation of stemlike cells and to address the mechanisms of EDTA-induced recovery under the hypothesis that attachment to the exposed dentin matrix and the subsequent activation of integrin/phosphatidylinositol 3-kinase (PI3K) signaling play a crucial role. METHODS: Mouse dental papilla (MDP) cells were cultured on bovine dentin disks treated with NaOCl (0%, 1...
February 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29215714/photobiomodulation-of-mesenchymal-stem-cells-encapsulated-in-an-injectable-rhbmp4-loaded-hydrogel-directs-hard-tissue-bioengineering
#8
Ivana M A Diniz, Ana C O Carreira, Carla R Sipert, Cindi M Uehara, Maria S N Moreira, Laila Freire, Cibele Pelissari, Patrícia M Kossugue, Daniele R de Araújo, Mari C Sogayar, Márcia M Marques
Photobiomodulation (PBM) therapy displays relevant properties for tissue healing and regeneration, which may be of interest for the tissue engineering field. Here, we show that PBM is able to improve cell survival and to interact with recombinant human Bone Morphogenetic Protein 4 (rhBMP4) to direct and accelerate odonto/osteogenic differentiation of dental derived mesenchymal stem cells (MSCs). MSCs were encapsulated in an injectable and thermo-responsive cell carrier (Pluronic® F-127) loaded with rhBMP4 and then photoactivated...
June 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29079051/minced-pulp-as-source-of-pulpal-mesenchymal-stem-cells-with-odontogenic-differentiation-capacity
#9
Zhangrui Liang, Satoshi Kawano, Wei Chen, Moein Seyed Sadrkhani, Chaehwan Lee, Euiseong Kim, Alireza Moshaverinia, Reuben H Kim, Mo K Kang
INTRODUCTION: Pulp tissue regeneration is becoming a reality after discovery of mesenchymal stem cells (MSCs) residing in the pulp tissues through various clinical innovations, although MSC transplantation into the pulp space has met with challenges of in vitro cell expansion and cultures. As a way to circumvent the regulatory and technical complexities of in vitro MSC culture, we investigated the use of minced pulp tissues as a source of pulpal MSCs for tissue regeneration. METHODS: We characterized the phenotype of cells explanted from minced pulp (MP), namely MP-derived MSCs (MP-MSCs), compared with dental pulp stem cells (DPSCs) established from pulp tissues by enzyme digestion...
January 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29030958/association-of-meox2-polymorphism-with-nonsyndromic-cleft-palate-only-in-a-vietnamese-population
#10
Duy L Tran, Hideto Imura, Akihiro Mori, Satoshi Suzuki, Teruyuki Niimi, Maya Ono, Chisato Sakuma, Shinichi Nakahara, Tham T H Nguyen, Phuong T Pham, Viet Hoang, Van T T Tran, Minh D Nguyen, Nagato Natsume
To evaluate the association between the single nucleotide polymorphism (SNP) rs227493 in the MEOX2 gene and nonsyndromic cleft palate only, this research was conducted as a case-control study by comparing a nonsyndromic cleft palate only group with an independent, healthy, and unaffected control group who were both examined by specialists. Based on clinical examination and medical records, we analyzed a total of 570 DNA samples, including 277 cases and 293 controls, which were extracted from dry blood spot samples collected from both the Odonto and Maxillofacial Hospital in Ho Chi Minh City and Nguyen Dinh Chieu Hospital in Ben Tre province, respectively...
October 14, 2017: Congenital Anomalies
https://www.readbyqxmd.com/read/28986711/blockade-of-lgr4-inhibits-proliferation-and-odonto-osteogenic-differentiation-of-stem-cells-from-apical-papillae
#11
Meng Zhou, Shuyu Guo, Lichan Yuan, Yuxin Zhang, Mengnan Zhang, Huimin Chen, Mengting Lu, Jianrong Yang, Junqing Ma
During tooth root development, stem cells from apical papillae (SCAPs) are indispensable, and their abilities of proliferation, migration and odontoblast differentiation are linked to root formation. Leucine-rich repeat-containing GPCR 4 (LGR4) modulates the biological processes of proliferation and differentiation in multiple stem cells. In this study, we showed that LGR4 is expressed in all odontoblast cell lineage cells and Hertwig's epithelial root sheath (HERS) during the mouse root formation in vivo. In vitro we determined that LGR4 is involved in the Wnt/β-catenin signaling pathway regulating proliferation and odonto/osteogenic differentiation of SCAPs...
December 2017: Journal of Molecular Histology
https://www.readbyqxmd.com/read/28881669/genetic-evaluations-of-chinese-patients-with-odontohypophosphatasia-resulting-from-heterozygosity-for-mutations-in-the-tissue-non-specific-alkaline-phosphatase-gene
#12
Jia Wan, Li Zhang, Tang Liu, Yewei Wang
BACKGROUND: Hypophosphatasia is a rare heritable metabolic disorder characterized by defective bone and tooth mineralization accompanied by a deficiency of tissue-non-specific (liver/bone/kidney) isoenzyme of alkaline phosphatase activity, caused by a number of loss-of-function mutations in the alkaline phosphatase liver type gene. We seek to explore the clinical manifestations and identify the mutations associated with the disease in a Chinese odonto- hypophosphatasia family. RESULTS: The proband and his younger brother affected with premature loss of primary teeth at their 2-year-old...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28860516/indirect-immobilized-jagged1-suppresses-cell-cycle-progression-and-induces-odonto-osteogenic-differentiation-in-human-dental-pulp-cells
#13
Jeeranan Manokawinchoke, Praphawi Nattasit, Tanutchaporn Thongngam, Prasit Pavasant, Kevin A Tompkins, Hiroshi Egusa, Thanaphum Osathanon
Notch signaling regulates diverse biological processes in dental pulp tissue. The present study investigated the response of human dental pulp cells (hDPs) to the indirect immobilized Notch ligand Jagged1 in vitro. The indirect immobilized Jagged1 effectively activated Notch signaling in hDPs as confirmed by the upregulation of HES1 and HEY1 expression. Differential gene expression profiling using an RNA sequencing technique revealed that the indirect immobilized Jagged1 upregulated genes were mainly involved in extracellular matrix organization, disease, and signal transduction...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28781092/properties-of-dental-pulp-derived-mesenchymal-stem-cells-and-the-effects-of-culture-conditions
#14
Nobuyuki Kawashima, Sonoko Noda, Mioko Yamamoto, Takashi Okiji
Dental pulp mesenchymal stem cells (DPMSCs) highly express mesenchymal stem cell markers and possess the potential to differentiate into neural cells, osteoblasts, adipocytes, and chondrocytes. Thus, DPMSCs are considered suitable for tissue regeneration. The colony isolation method has commonly been used to collect relatively large amounts of heterogeneous DPMSCs. Homogenous DPMSCs can be isolated by fluorescence-activated cell sorting using antibodies against mesenchymal stem cell markers, although this method yields a limited number of cells...
August 3, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28749049/mineral-trioxide-aggregate-enhances-the-osteogenic-capacity-of-periodontal-ligament-stem-cells-via-nf-%C3%AE%C2%BAb-and-mapk-signaling-pathways
#15
Yanqiu Wang, Yixiang Zhou, Lin Jin, Xiyao Pang, Yadie Lu, Zilu Wang, Yan Yu, Jinhua Yu
Mineral trioxide aggregate (MTA), as a bioactive material, has a widespread application in clinical practice. To date, the effects of MTA on the proliferation and differentiation of human periodontal ligament stem cells (hPDLSCs) remain unclear. hPDLSCs were isolated from human periodontal ligament tissues and cultured with MTA conditioned media. Cell counting kit-8 (CCK-8) assay was performed to assess the proliferation capacity of MTA-treated hPDLSCs. Immunofluorescence assay, alkaline phosphatase (ALP) activity, alizarin red staining, real-time RT-PCR, and western blot analyses were used to investigate the odonto/osteogenic capacity of hPDLSCs as well as the involvement of NF-κB and MAPK pathways...
March 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28711896/computer-tomographic-characteristics-of-root-length-incisors-and-canines-of-the-upper-and-lower-jaws-in-boys-and-girls-with-different-craniotypes-and-physiological-bite
#16
Аlla V Маrchenko, Іgor V Gunas, Tetyana O Petrushanko, Oksana А Serebrennikova, Yulia Yu Trofimenko
INTRODUCTION: In recent years, in world literature appeared research, which focuses on the study of relationships craniotypes with odonto-metric indicators, size, shape of the dental arches and occlusion. However, most of the experts focus on the study of individual features of the structure of the teeth-jaw system in people with different types of faces and aspects of sexual dimorphism and ethnic characteristics. Studies containing information about cranio-typological variability of the roots of teeth we did not encounter...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28615507/genetic-evaluations-of-chinese-patients-with-odontohypophosphatasia-resulting-from-heterozygosity-for-mutations-in-the-tissue-non-specific-alkaline-phosphatase-gene
#17
Jia Wan, Li Zhang, Tang Liu, Yewei Wang
BACKGROUND: Hypophosphatasia is a rare heritable metabolic disorder characterized by defective bone and tooth mineralization accompanied by a deficiency of tissue-non-specific (liver/bone/kidney) isoenzyme of alkaline phosphatase activity, caused by a number of loss-of-function mutations in the alkaline phosphatase liver type gene. We seek to explore the clinical manifestations and identify the mutations associated with the disease in a Chinese odonto- hypophosphatasia family. RESULTS: The proband and his younger brother affected with premature loss of primary teeth at their 2-year-old...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28586929/-keratoprosthesis-with-biological-haptic-the-d%C3%A3-sseldorf-offenburg-experience-with-osteo-odonto-and-tibia-keratoprosthesis
#18
Gerd Geerling, Konrad Hille
In severe ocular surface disease with limbal stem cell deficiency associated with severe dry eye, penetrating keratoplasty is likely to fail. In these cases, and provided the posterior segment is normal, keratoprosthesis surgery (KPro) can achieve visual rehabilitation. In KPros with an autologous biological haptic, a bone-tooth-complex (osteo-odonto-keratoprothesis, OOKPro) or a piece of tibial cortex (tibia-keratoprosthesis, TKPro) is used to carry a PMMA cylinder. This construct can successfully be implanted even in severely dry eyes and in those with autoimmune disease, in which other KPro designs frequently fail...
June 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28497901/risk-factors-of-periodontal-disease-in-vietnamese-patients
#19
Thuy A V Pham, Thoai Q Kieu, Lan T Q Ngo
AIM: The aim of the present study was to assess the association of periodontitis with dental and smoking behaviors, self-perception of oral status, dental knowledge, and obesity in Vietnamese patients. METHODS: A cross-sectional study was conducted on 367 adults who first visited the Faculty of Odonto-Stomatology, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam. Information on demographic characteristics, dental and smoking behaviors, self-perception of oral status, dental knowledge, and nutritional status was investigated by a self-administered questionnaire...
May 12, 2017: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/28484851/-long-term-outcome-of-keratoprosthesis-with-biological-support
#20
K Hille
BACKGROUND: In severe Sicca syndrome and limbal stem cell deficiency, vision can be restored by an artificial optical implant into the cornea (keratoprosthesis, KPro). After multiple efforts to achieve long-lasting corneal fixation of such an optical implant, two methods have become established: KPro with biological support, such as osteo-odonto-keratoprosthesis (OOKP) made from the root of patient's own tooth or osteo-keratoprosthesis (OKP), made from cortical bone of the patient's tibia; and the Boston KPro...
January 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
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