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https://www.readbyqxmd.com/read/29149256/structural-and-immunodiagnostic-characterization-of-synthetic-antigen-b-subunits-from-echinococcus-granulosus-and-their-evaluation-as-target-antigens-for-cyst-viability-assessment
#1
Daniela Pagnozzi, Francesca Tamarozzi, Anna Maria Roggio, Vittorio Tedde, Maria Filippa Addis, Salvatore Pisanu, Gabriella Masu, Cinzia Santucciu, Ambra Vola, Adriano Casulli, Giovanna Masala, Enrico Brunetti, Sergio Uzzau
Background: Several tools have been proposed for serodiagnosis of cystic echinococcosis (CE), but none appears promising for cyst viability assessment. Antigens with stage-specific diagnostic value have been described, but few studies with well-characterized antigens and human sera have been performed. Antigen B (AgB) proteoforms hold promise as markers of viability, due to their differential stage-related expression and immunoreactivity. Methods: Four AgB subunits (AgB1, AgB2, AgB3, AgB4) were synthesized and structurally characterized...
November 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29148537/adenomatoid-tumors-of-the-male-and-female-genital-tract-are-defined-by-traf7-mutations-that-drive-aberrant-nf-kb-pathway-activation
#2
Benjamin Goode, Nancy M Joseph, Meredith Stevers, Jessica Van Ziffle, Courtney Onodera, Eric Talevich, James P Grenert, Iwei Yeh, Boris C Bastian, Joanna J Phillips, Karuna Garg, Joseph T Rabban, Charles Zaloudek, David A Solomon
Adenomatoid tumors are the most common neoplasm of the epididymis, and histologically similar adenomatoid tumors also commonly arise in the uterus and fallopian tube. To investigate the molecular pathogenesis of these tumors, we performed genomic profiling on a cohort of 31 adenomatoid tumors of the male and female genital tracts. We identified that all tumors harbored somatic missense mutations in the TRAF7 gene, which encodes an E3 ubiquitin ligase belonging to the family of tumor necrosis factor receptor-associated factors (TRAFs)...
November 17, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29147081/skull-meningioma-associated-with-intradural-cyst-a-case-report
#3
Genshin Mouri, Hidenori Suzuki, Seiji Hatazaki, Toshio Matsubara, Waro Taki
We present the first report of intraosseous meningioma accompanied by intradural cyst formation. A 76-year-old woman had previously undergone breast cancer treatment, so the preoperative diagnosis was metastatic breast cancer. This case reminds us that the possibility of meningioma should be kept in mind in patients with breast cancer, irrespective of neuroimaging findings.
2017: Clinical Medicine Insights. Case Reports
https://www.readbyqxmd.com/read/29146893/von-hippel-lindau-disease-with-multi-organ-involvement-a-case-report-and-8-year-clinical-course-with-follow-up
#4
Ali Yaghobi Joybari, Payam Azadeh
BACKGROUND Von Hippel-Lindau (VHL) disease is a rare autosomal dominant syndrome manifested by a spectrum of benign and malignant tumors.  CASE REPORT The patient presented here was a 31-year-old female with unremarkable family history who presented initially complaining of intermittent abdominal pain. Abdominal CT scan revealed an inhomogeneous solid mass (13×9×7 cm) originating from the tail of the pancreas with splenic and gastric invasion as well as several pancreatic cysts. A nucleotide scan showed left adrenal involvement...
November 17, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29146436/rupture-of-intra-ventricular-hydatid-cyst-the-camalote-sign
#5
Nishanth Sadashiva, Dhaval Shukla, Bhagavatula Indira Devi
Only a few cases of intraventricular hydatid cysts have been described. The Camalote or waterlily sign is described when there is detachment of the endocyst membrane, resulting in a floating appearance like a waterlily. This sign has been described most commonly in hepatic cysts. Here, we describe the camalote sign in an iatrogenically ruptured intraventricular hydatid cyst. Rupture of an intraventricular hydatid cyst poses the threat of widespread dissemination and is described in our case.
November 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29145907/-autosomal-dominant-polycystic-kidney-disease-should-patients-young-adult-relatives-be-screened-or-not
#6
B J Kramers, M Storm, R T Gansevoort
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disease, with a global prevalence of 10 per 10,000. It is characterized by the formation of numerous cysts in both kidneys, and leads to renal function loss; the majority of patients will eventually need renal replacement therapy. It is possible to screen patients' presymptomatic family members from a young age, but this has not historically been recommended as until recently there were no treatment options. This year, the vasopressin V2 receptor antagonist tolvaptan was approved for prescription in ADPKD, to slow the rate of renal function decline...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29145875/re-visiting-the-detection-of-porcine-cysticercosis-based-on-full-carcass-dissections-of-naturally-taenia-solium-infected-pigs
#7
Mwelwa Chembensofu, K E Mwape, I Van Damme, E Hobbs, I K Phiri, M Masuku, G Zulu, A Colston, A L Willingham, B Devleesschauwer, A Van Hul, A Chota, N Speybroeck, D Berkvens, P Dorny, S Gabriël
BACKGROUND: Taenia solium is a neglected zoonotic parasite. The performances of existing tools for the diagnosis of porcine cysticercosis need further assessment, and their shortcomings call for alternatives. The objective of this study was to evaluate the performance of tongue palpation and circulating antigen detection for the detection of porcine cysticercosis in naturally infected pigs of slaughter age compared to full carcass dissections (considered the gold standard). Additionally, alternative postmortem dissection procedures were investigated...
November 16, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29145282/autosomal-dominant-polycystic-kidney-disease-combined-with-hypertrophic-cardiomyopathy-a-case-report
#8
Yingjing Shen, Chenggang Xu
INTRODUCTION: This report describes the novel sampling of autosomal dominant polycystic kidney disease (ADPKD) combined with hypertrophic cardiomyopathy (HCM). SYMPTOMS AND CLINICAL FINDINGS: A 48-year-old Chinese man presented with anasarca, hypourocrinia, gross hematuria, and weight gain by 10 kg subsequently developed acute kidney injury after struck by acute respiratory distress syndrome, really a threat to his heart. DIAGNOSES: Abdominal ultrasound revealed multiple small cysts in both kidneys, with the right kidney measuring 11...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145274/diagnosis-of-fetal-megacystis-with-chromosomal-abnormality-by-2d-prenatal-ultrasound-a-case-report
#9
Fuman She, Shengwen Dong, Bibo Yuan, Xiaoli Gao
RATIONALE: The pathogenesis of fetal megacystis is divided into obstructive and nonobstructive. Megacystis combined with chromosomal abnormalities is rare and most of the cases are nonobstructive. PATIENT CONCERNS: The fetus showed posterior urethral obstructive megacystis with features of bladder enlargement, "keyhole" feature, and thick bladder wall. DIAGNOSES: Here, we present a case of fetal megacystis diagnosed by ultrasound at pregnancy week 15+2 and with multisystem abnormalities...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145248/esophageal-duplication-cyst-with-hemivertebrae-a-case-report-and-literature-review
#10
Yanfang Liu, Ling Zhou, Shuixue Li, Jun He, Abudusaimi, Kai Li, Aziguli, Haixia Yao
BACKGROUND: Esophageal duplication cysts (EDCs) are rare congenital anomalies that can be associated with symptomatic spinal abnormalities, but presentations due to EDC symptoms are rarely found in the presence of spinal abnormalities. CASE SUMMARY: A 6-month-old infant weighing approximately 5.0 kg presented with a 2-month pulmonary infection and more recent difficulty swallowing and nutritional intolerance that did not improve with medical treatment. Contrast-enhanced chest computed tomography showed a well-defined, mediastinal, homogeneous, low-density cystic mass of 11...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144832/postoperative-complications-of-dermis-fat-autografts-in-the-anophthalmic-socket
#11
Victoria Starks, Suzanne K Freitag
Reconstruction of the anophthalmic socket allows the use of an ocular prosthesis and rehabilitation of facial appearance. Dermis-fat grafting is one option in volume augmentation of the anophthalmic socket and presents unique benefits, including increased surface area within the socket and the ability to grow with pediatric patients. Postoperative complications of this procedure are relatively common. Minor complications, such as graft hirsutism, keratinization, and conjunctival cysts or granulomas, are managed easily by observation or simple intervention...
November 16, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/29144772/subchondral-bone-degradation-after-microfracture-for-osteochondral-lesions-of-the-talus-an-mri-analysis
#12
Yoshiharu Shimozono, Max Coale, Youichi Yasui, Amanda O'Halloran, Timothy W Deyer, John G Kennedy
BACKGROUND: Microfracture is the most common cartilage-reparative procedure for the treatment of osteochondral lesions of the talus (OLTs). Damage to the subchondral bone (SCB) during microfracture may irreversibly change the joint-loading support of the ankle, leading to reparative fibrocartilage degradation over time. PURPOSE: To investigate the morphological change in the SCB after microfracture for OLT by developing a novel magnetic resonance imaging (MRI) scoring system specifically for evaluating the SCB...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29144421/paralytic-shellfish-toxins-and-cyanotoxins-in-the-mediterranean-new-data-from-sardinia-and-sicily-italy
#13
Antonella Lugliè, Maria Grazia Giacobbe, Elena Riccardi, Milena Bruno, Silvia Pigozzi, Maria Antonietta Mariani, Cecilia Teodora Satta, Daniela Stacca, Anna Maria Bazzoni, Tiziana Caddeo, Pasqualina Farina, Bachisio Mario Padedda, Silvia Pulina, Nicola Sechi, Anna Milandri
Harmful algal blooms represent a severe issue worldwide. They affect ecosystem functions and related services and goods, with consequences on human health and socio-economic activities. This study reports new data on paralytic shellfish toxins (PSTs) from Sardinia and Sicily (Italy), the largest Mediterranean islands where toxic events, mainly caused by Alexandrium species (Dinophyceae), have been ascertained in mussel farms since the 2000s. The toxicity of the A. minutum, A. tamarense and A. pacificum strains, established from the isolation of vegetative cells and resting cysts, was determined by high performance liquid chromatography (HPLC)...
November 16, 2017: Microorganisms
https://www.readbyqxmd.com/read/29143944/one-thousand-seventy-eight-autologous-ivf-cycles-in-women-45%C3%A2-years-and-older-the-largest-single-center-cohort-to-date
#14
Vinay Gunnala, Mohamad Irani, Alexis Melnick, Zev Rosenwaks, Steven Spandorfer
PURPOSE: The purpose of this study was to determine IVF outcomes in women 45 years and older using autologous oocytes. METHODS: This is a retrospective cohort study reviewing all IVF cycles in women ≥ 45 years old from January 1995 to June 2015 that were conducted at one academic medical center. One thousand seventy-eight fresh, autologous IVF cycles met inclusion criteria. PGD/S, natural IVF, and donor egg cycles were excluded. Outcomes were analyzed for the different age groups (age 45, n = 773; age 46, n = 221; age 47, n = 57; age 48, n = 22; age 49, n = 5)...
November 16, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29143370/coronary-artery-bypass-graft-surgery-in-a-patient-with-a-giant-pericardial-cyst
#15
Marco Russo, Paolo Nardi, Fabio Bertoldo, Leonardo Calò, Giovanni Ruvolo
No abstract text is available yet for this article.
November 16, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29143119/infectious-and-non-infectious-diseases-causing-the-air-crescent-sign-a-state-of-the-art-review
#16
REVIEW
Joyce Betta Sevilha, Rosana Souza Rodrigues, Miriam Menna Barreto, Gláucia Zanetti, Bruno Hochhegger, Edson Marchiori
Aspergilloma, also known as mycetoma or fungus ball, is characterized by a round or oval mass with soft-tissue attenuation within a preexisting lung cavity. The typical computed tomography (CT) aspect of an aspergilloma is a mass separated from the wall of the cavity by an airspace of variable size and shape, resulting in the air crescent sign, also known as the meniscus sign. This CT feature is non-specific and can be simulated by several other entities that result in intracavitary masses. This review describes the main clinical and imaging aspects of the infectious and non-infectious diseases that may present with fungus-ball appearance, including pulmonary hydatid cyst, Rasmussen aneurysm, pulmonary gangrene, intracavitary clot, textiloma, lung cancer, metastasis, and teratoma, focusing on the differential diagnosis...
November 15, 2017: Lung
https://www.readbyqxmd.com/read/29143062/-intracranial-cystic-lesions
#17
REVIEW
F Ahlhelm, K Shariat, S Götschi, S Ulmer
CLINICAL PROBLEM: Intracerebral cysts are common findings in imaging of the neurocranium and are not always clinically significant. The pathological spectrum of intracerebral cysts is, however, very broad and in addition to incidental findings includes developmental disorders, malformation tumors, primary and secondary neoplasms and infectious etiologies, such as cerebral abscess formation, cysticercosis or residuals after congenital cytomegalovirus infections. Intracerebral cystic defects may be caused by inflammatory central nervous system (CNS) diseases, such as multiple sclerosis as well as by mitochondriopathies, leukodystrophy, electrolyte disturbances or osmotic demyelination syndrome or brain infarctions, e...
November 15, 2017: Der Radiologe
https://www.readbyqxmd.com/read/29142941/the-longitudinal-study-of-liver-cysts-in%C3%A2-patients-with-autosomal-dominant-polycystic-kidney-disease-and-polycystic-liver-disease
#18
Ryo Matsuura, Kenjiro Honda, Yoshifumi Hamasaki, Kent Doi, Eisei Noiri, Masaomi Nangaku
Introduction: Although polycystic liver disease (PCLD) is one of the extrarenal complications in patients with autosomal dominant polycystic kidney disease (ADPKD), longitudinal changes and the association with total liver volume (TLV) have not been clearly elucidated yet. Methods: Patients with ADPKD were chosen who underwent computed tomography or magnetic resonance imaging twice or more during August 2003 through December 2015. TLV, each cyst volume, and the proportion of parenchyma were measured...
January 2017: KI Reports
https://www.readbyqxmd.com/read/29142791/management-of-massively-enlarged-multiple-hydatid-cysts-in-the-liver-of-a-pediatric-patient
#19
Faizan Yasin, Haider Ghazanfar, Salman Assad, Sumbal A Bhatti
Multiple hydatid cysts in the liver are a very rare occurrence in childhood. We present a similar case in a nine-year-old girl, a resident in a rural community, who presented with two hydatid cysts in her liver. The cysts were operated upon by a pediatric surgeon. The laboratory findings of this patient showed peripheral blood eosinophilia, elevated white blood cells, and liver enzymes. The serology was positive. The ultrasonography showed cystic masses in the liver, and the diagnosis of hydatid cysts was eventually confirmed by computed tomography (CT) of the abdomen...
September 2, 2017: Curēus
https://www.readbyqxmd.com/read/29142790/an-active-giant-cell-tumor-of-the-patella-a-case-report
#20
Svetoslav A Slavchev, Georgi P Georgiev, Kircho Patrikov
Primary neoplasms of the patella account for less than 1% of all primary bone tumors of the lower extremity, the most frequent of them being the giant cell tumor of bone, the chondroblastoma, and the aneurysmal bone cyst. Herein, we report the case of a 29-year-old woman with an active giant cell tumor of the patella (GCTP) with its clinical and radiological features and a brief review of the literature.
September 2, 2017: Curēus
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