Maria K Lagou, Dimitrios G Argyris, Stepan Vodopyanov, Leslie Gunther-Cummins, Alexandros Hardas, Theofilos Poutahidis, Christos Panorias, Sophia DesMarais, Conner Entenberg, Randall S Carpenter, Hillary Guzik, Xheni Nishku, Joseph Churaman, Maria Maryanovich, Vera DesMarais, Frank P Macaluso, George S Karagiannis
The thymus, a central primary lymphoid organ of the immune system, plays a key role in T cell development. Surprisingly, the thymus is quite neglected with regards to standardized pathology approaches and practices for assessing structure and function. Most studies use multispectral flow cytometry to define the dynamic composition of the thymus at the cell population level, but they are limited by lack of contextual insight. This knowledge gap hinders our understanding of various thymic conditions and pathologies, particularly how they affect thymic architecture, and subsequently, immune competence...
March 14, 2024: bioRxiv