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https://www.readbyqxmd.com/read/28890536/a-key-role-for-il-7r-in-the-generation-of-microenvironments-required-for-thymic-dendritic-cells
#1
Amanda J Moore, Tracy Sh In, Ashton Trotman-Grant, Kogulan Yoganathan, Bertrand Montpellier, Cynthia J Guidos, Juan Carlos Zúñiga-Pflücker, Michele K Anderson
Interleukin-7 receptor (IL-7R) signaling is critical for multiple stages of T-cell development, but a role in the establishment of the mature thymic architecture needed for T-cell development and thymocyte selection has not been established. Crosstalk signals between developing thymocytes and thymic epithelial cell (TEC) precursors are critical for their differentiation into cortical TECs (cTECs) and medullary TECs (mTECs). Additionally, mTECs-derived factors have been implicated in the recruitment of thymic dendritic cells (DCs) and intrathymic DC development...
September 11, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28888743/htlv-1-infected-thymic-epithelial-cells-convey-the-virus-to-cd4-t-lymphocytes
#2
Luciana Rodrigues Carvalho Barros, Leandra Linhares-Lacerda, Klaysa Moreira-Ramos, Marcelo Ribeiro-Alves, Maria Cristina Machado Motta, Dumith Chequer Bou-Habib, Wilson Savino
The human T-lymphotropic virus type-1 (HTLV-1) is the causative agent of adult T cell leukemia/lymphoma (ATL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). CD4(+)T cells are the main target of HTLV-1, but other cell types are known to be infected, including immature lymphocytes. Developing T cells undergo differentiation in the thymus, through migration and interaction with the thymic microenvironment, in particular with thymic epithelial cells (TEC) the major component of this three dimensional meshwork of non-lymphoid cells...
August 14, 2017: Immunobiology
https://www.readbyqxmd.com/read/28886197/in-vivo-lineage-tracing-reveals-axin2-expressing-long-lived-cortical-thymic-epithelial-progenitors-in-the-postnatal-thymus
#3
Si Hui Tan, Roel Nusse
In the thymus, cortical and medullary thymic epithelial cells (TECs) are instrumental for generating a repertoire of functional T cells. Hence, there has been much interest in the ontogeny of TECs. While medullary TEC (mTEC) and bipotent progenitors have been identified, the existence of a cortical TEC (cTEC) progenitor remains ambiguous. In this study, we used lineage tracing based on a target gene of the Wnt pathway, Axin2. We found that Axin2 initially labels cells in both the cortical and medullary compartments...
2017: PloS One
https://www.readbyqxmd.com/read/28876896/differential-kinobeads-profiling-for-target-identification-of-irreversible-kinase-inhibitors
#4
Lars Dittus, Thilo Werner, Marcel Muelbaier, Marcus Bantscheff
Chemoproteomics profiling of kinase inhibitors with kinobeads enables the assessment of inhibitor potency and selectivity for endogenously expressed protein kinases in cell lines and tissues. Using a small panel of targeted covalent inhibitors, we demonstrate the importance of measuring covalent target binding in live cells. We present a differential kinobeads profiling strategy for covalent kinase inhibitors where a compound is added either to live cells or to a cell extract that enables the comprehensive assessment of inhibitor selectivity for covalent and noncovalent targets...
September 12, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28871142/genetic-and-non-genetic-determinants-of-thymic-epithelial-cell-number-and-function
#5
Daisuke Nagakubo, Brigitte Krauth, Thomas Boehm
The thymus is the site of T cell development in vertebrates. In general, the output of T cells is determined by the number of thymic epithelial cells (TECs) and their relative thymopoietic activity. Here, we show that the thymopoietic activity of TECs differs dramatically between individual mouse strains. Moreover, in males of some strains, TECs perform better on a per cell basis than their counterparts in females; in other strains, this situation is reversed. Genetic crosses indicate that TEC numbers and thymopoietic capacity are independently controlled...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28858418/effect-of-access-design-on-intracoronal-bleaching-of-endodontically-treated-teeth-an-ex-vivo-study
#6
Melissa Andreia Marchesan, Christopher Michael James, Adam Lloyd, Brian Ray Morrow, Franklin García-Godoy
OBJECTIVES: To determine the effect of access design on intracoronal bleaching with 35% carbamide peroxide on discolored teeth. MATERIALS AND METHODS: Forty-two intact maxillary central incisors were selected, sectioned and artificially stained using whole blood. Color measurements were performed with a spectrophotometer: before staining (T1), after staining (T2), at 7 (T3), and 14 (T4) days postbleaching. After T1, specimens were stratified and divided randomly into two groups according to access design (N = 20): G1: contracted endodontic cavity (CEC) access performed with a #848-010M bur and G2: traditional endodontic cavity (TEC) access done with a #1157 bur...
August 31, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/28855190/extracellular-vesicles-as-immune-mediators-in-response-to-kidney-injury
#7
Eva Feigerlova, Shyue-Fang Battaglia-Hsu, Thierry Hauet, Jean-Louis Guéant
Important progress has been made on the cytokine signalling in response to kidney injury in the past decade, especially cytokine signalling mediated by extracellular vesicles (EVs). For example, EVs released by injured renal tubular epithelial cells (TECs) can regulate inter-cellular communications and influence tissue recovery via both regulating the expression and transferring cytokines, growth factors, as well as other bioactive molecules at the site of injury. The effects of EVs on kidney tissue seem to vary depending on the sources of EVs; however, the literature data are often inconsistent...
August 30, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28837526/mitochondrial-dna-is-released-in-urine-of-sirs-patients-with-acute-kidney-injury-and-correlates-with-severity-of-renal-dysfunction
#8
Marcel P B Jansen, Wilco P Pulskens, Loes M Butter, Sandrine Florquin, Nicole P Juffermans, Joris J T H Roelofs, Jaklien C Leemans
Systemic inflammatory response syndrome (SIRS) is characterized by the activation of the innate immune system resulting in stimulation of inflammatory responses, coagulation, and platelet activation, that may contribute to complication such as the development of acute kidney injury (AKI). AKI importantly worsens the outcome of SIRS, implying the existence of a detrimental cross-talk via systemic messages. Mitochondria are a source of damage-associated molecular patterns (DAMPs) and are thought to form a molecular link between tissue injury and stimulation of innate immunity...
August 23, 2017: Shock
https://www.readbyqxmd.com/read/28837255/role-of-the-chalcogen-s-se-te-in-the-oxidation-mechanism-of-the-glutathione-peroxidase-active-site
#9
Marco Bortoli, Mauro Torsello, F Matthias Bickelhaupt, Laura Orian
The oxidation by H2O2 of the human phospholipid hydroperoxide glutathione peroxidase (GPx4), used as model peroxidase selenoenzyme, as well as of its cysteine (Cys) and tellurocysteine (Tec) mutants, is investigated in silico through a combined classic and quantum mechanics approach to assess the role of the different chalcogens. To perform this analysis, new parameters for selenocysteine (Sec) and tellurocysteine (Tec) were accurately derived for the AMBER ff14SB force field. The oxidation represents the initial step of the anti-oxidant activity of GPx, which catalyzes the reduction of H2O2 and organic hydroperoxides by glutathione (GSH)...
August 24, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28832713/comparing-depth-dependent-curing-radiant-exposure-and-time-of-curing-of-regular-and-flow-bulk-fill-composites
#10
Jose Augusto Rodrigues, Ilana Pais Tenorio, Ginger Baranhuk Rabello de Mello, André Figueiredo Reis, Chiayi Shen, Jean-François Roulet
The effect of restoration depth on the curing time of a conventional and two bulk-fill composite resins by measuring microhardness and the respective radiosity of the bottom surface of the specimen was investigated. 1-, 3- and 5-mm thick washers were filled with Surefil SDR Flow-U (SDR), Tetric EvoCeram Bulk Fill-IVA (TEC) or Esthet-X HD-B1 (EHD), and cured with Bluephase® G2 for 40s. Additional 1-mm washers were filled with SDR, TEC or EHD, placed above the light sensor of MARC®, stacked with pre-cured 1-, 3- or 5-mm washer of respective material, and cured for 2...
August 21, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28831229/baseline-hematology-and-serum-biochemistry-results-for-indian-leopards-panthera-pardus-fusca
#11
Arun Attur Shanmugam, Sanath Krishna Muliya, Ajay Deshmukh, Sujay Suresh, Anukul Nath, Pa Kalaignan, Manjunath Venkataravanappa, Lyju Jose
AIM: The aim of the study was to establish the baseline hematology and serum biochemistry values for Indian leopards (Panthera pardus fusca), and to assess the possible variations in these parameters based on age and gender. MATERIALS AND METHODS: Hemato-biochemical test reports from a total of 83 healthy leopards, carried out as part of routine health evaluation in Bannerghatta Biological Park and Manikdoh Leopard Rescue Center, were used to establish baseline hematology and serum biochemistry parameters for the subspecies...
July 2017: Veterinary World
https://www.readbyqxmd.com/read/28830910/redefining-thymus-medulla-specialization-for-central-tolerance
#12
Emilie J Cosway, Beth Lucas, Kieran D James, Sonia M Parnell, Manuela Carvalho-Gaspar, Andrea J White, Alexei V Tumanov, William E Jenkinson, Graham Anderson
During αβT cell development, the thymus medulla represents an essential microenvironment for T cell tolerance. This functional specialization is attributed to its typical organized topology consisting of a branching structure that contains medullary thymic epithelial cell (mTEC) networks to support negative selection and Foxp3(+) T-regulatory cell (T-reg) development. Here, by performing TEC-specific deletion of the thymus medulla regulator lymphotoxin β receptor (LTβR), we show that thymic tolerance mechanisms operate independently of LTβR-mediated mTEC development and organization...
August 22, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28828144/assessment-of-radiometer-calibration-with-gps-radio-occultation-for-the-mirata-cubesat-mission
#13
Anne D Marinan, Kerri L Cahoy, Rebecca L Bishop, Susan S Lui, James R Bardeen, Tamitha Mulligan, William J Blackwell, R Vincent Leslie, Idahosa Osaretin, Michael Shields
The Microwave Radiometer Technology Acceleration (MiRaTA) is a 3U CubeSat mission sponsored by the NASA Earth Science Technology Office (ESTO). The science payload on MiRaTA consists of a tri-band microwave radiometer and Global Positioning System (GPS) radio occultation (GPSRO) sensor. The microwave radiometer takes measurements of all-weather temperature (V-band, 50-57 GHz), water vapor (G-band, 175-191 GHz), and cloud ice (G-band, 205 GHz) to provide observations used to improve weather forecasting. The Aerospace Corporation's GPSRO experiment, called the Compact TEC (Total Electron Content) and Atmospheric GPS Sensor (CTAGS), measures profiles of temperature and pressure in the upper troposphere/lower stratosphere (∼20 km) and electron density in the ionosphere (over 100 km)...
December 2016: IEEE J Sel Top Appl Earth Obs Remote Sens
https://www.readbyqxmd.com/read/28814583/does-use-of-point-of-care-testing-improve-cost-effectiveness-of-the-nhs-health-check-programme-in-the-primary-care-setting-a-cost-minimisation-analysis
#14
Austen El-Osta, Maria Woringer, Elena Pizzo, Talitha Verhoef, Claire Dickie, Melody Z Ni, Jeremy R Huddy, Michael Soljak, George B Hanna, Azeem Majeed
OBJECTIVE: To determine if use of point of care testing (POCT) is less costly than laboratory testing to the National Health Service (NHS) in delivering the NHS Health Check (NHSHC) programme in the primary care setting. DESIGN: Observational study and theoretical mathematical model with microcosting approach. SETTING: We collected data on NHSHC delivered at nine general practices (seven using POCT; two not using POCT). PARTICIPANTS: We recruited nine general practices offering NHSHC and a pathology services laboratory in the same area...
August 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28814544/direct-detection-of-early-stage-cancers-using-circulating-tumor-dna
#15
Jillian Phallen, Mark Sausen, Vilmos Adleff, Alessandro Leal, Carolyn Hruban, James White, Valsamo Anagnostou, Jacob Fiksel, Stephen Cristiano, Eniko Papp, Savannah Speir, Thomas Reinert, Mai-Britt Worm Orntoft, Brian D Woodward, Derek Murphy, Sonya Parpart-Li, David Riley, Monica Nesselbush, Naomi Sengamalay, Andrew Georgiadis, Qing Kay Li, Mogens Rørbæk Madsen, Frank Viborg Mortensen, Joost Huiskens, Cornelis Punt, Nicole van Grieken, Remond Fijneman, Gerrit Meijer, Hatim Husain, Robert B Scharpf, Luis A Diaz, Siân Jones, Sam Angiuoli, Torben Ørntoft, Hans Jørgen Nielsen, Claus Lindbjerg Andersen, Victor E Velculescu
Early detection and intervention are likely to be the most effective means for reducing morbidity and mortality of human cancer. However, development of methods for noninvasive detection of early-stage tumors has remained a challenge. We have developed an approach called targeted error correction sequencing (TEC-Seq) that allows ultrasensitive direct evaluation of sequence changes in circulating cell-free DNA using massively parallel sequencing. We have used this approach to examine 58 cancer-related genes encompassing 81 kb...
August 16, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28806608/differential-effects-of-childhood-trauma-subtypes-on-fatigue-and-physical-functioning-in-chronic-fatigue-syndrome
#16
Maud De Venter, Jela Illegems, Rita Van Royen, Greta Moorkens, Bernard G C Sabbe, Filip Van Den Eede
OBJECTIVE: There is wide consensus that childhood trauma plays an important role in the aetiology of chronic fatigue syndrome (CFS). The current study examines the differential effects of childhood trauma subtypes on fatigue and physical functioning in individuals suffering from CFS. METHODS: Participants were 155 well-documented adult, predominantly female CFS patients receiving treatment at the outpatient treatment centre for CFS of the Antwerp University Hospital in Belgium...
July 19, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28805677/endocytosis-of-albumin-induces-matrix-metalloproteinase-9-by-activating-the-erk-signaling-pathway-in-renal-tubule-epithelial-cells
#17
Xiaoming Chen, Alyssa Cobbs, Jasmine George, Ashmeer Chima, Fidele Tuyishime, Xueying Zhao
Matrix metalloproteinase-9 (MMP-9) is dysregulated in chronic kidney diseases including diabetic nephropathy. This study was performed to examine the expression of MMP-9 in renal tubule epithelial cells (TECs) under diabetic conditions and its regulatory mechanisms. We characterized MMP-9 protein in diabetic animals and primary cultured rat TECs exposed to exogenous albumin and high glucose. We also used specific inhibitors to determine if internalization of albumin and/or extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation were required for MMP-9 secretion...
August 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28802993/microbial-community-structure-and-activity-in-trace-element-contaminated-soils-phytomanaged-by-gentle-remediation-options-gro
#18
M Touceda-González, Á Prieto-Fernández, G Renella, L Giagnoni, A Sessitsch, G Brader, J Kumpiene, I Dimitriou, J Eriksson, W Friesl-Hanl, R Galazka, J Janssen, M Mench, I Müller, S Neu, M Puschenreiter, G Siebielec, J Vangronsveld, P S Kidd
Gentle remediation options (GRO) are based on the combined use of plants, associated microorganisms and soil amendments, which can potentially restore soil functions and quality. We studied the effects of three GRO (aided-phytostabilisation, in situ stabilisation and phytoexclusion, and aided-phytoextraction) on the soil microbial biomass and respiration, the activities of hydrolase enzymes involved in the biogeochemical cycles of C, N, P, and S, and bacterial community structure of trace element contaminated soils (TECS) from six field trials across Europe...
August 10, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28801669/balance-between-estrogens-and-proinflammatory-cytokines-regulates-chemokine-production-involved-in-thymic-germinal-center-formation
#19
Nadine Dragin, Patrice Nancy, José Villegas, Régine Roussin, Rozen Le Panse, Sonia Berrih-Aknin
The early-onset form of Myasthenia Gravis (MG) is prevalent in women and associates with ectopic germinal centers (GCs) development and inflammation in the thymus. we aimed to investigate the contribution of estrogens in the molecular processes involved in thymic GCs formation. We examined expression of genes involved in anti-acetylcholine receptor (AChR) response in MG, MHC class II and α-AChR subunit as well as chemokines involved in GC development (CXCL13, CCL21and CXCL12). In resting conditions, estrogens have strong regulatory effects on thymic epithelial cells (TECs), inducing a decreased protein expression of the above molecules...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28800844/first-comparative-analysis-concerning-the-plasma-platelet-contamination-during-mnc-collection
#20
Hella Pfeiffer, Susanne Achenbach, Julian Strobel, Robert Zimmermann, Reinhold Eckstein, Erwin F Strasser
BACKGROUND AND OBJECTIVES: Monocytes can be cultured into dendritic cells with addition of autologous plasma, which is highly prone to platelet contamination due to the apheresis process. Since platelets affect the maturation process of monocytes into dendritic cells and might even lead to a diminished harvest of dendritic cells, it is very important to reduce the platelet contamination. A new collection device (Spectra Optia) was analyzed, compared to two established devices (COM.TEC, Cobe Spectra) and evaluated regarding the potential generation of source plasma...
July 13, 2017: Transfusion and Apheresis Science
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