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https://www.readbyqxmd.com/read/28527400/effects-of-combretastatin-a-4-phosphate-on-canine-normal-and-tumor-tissue-derived-endothelial-cells
#1
Yusuke Izumi, Keisuke Aoshima, Yuki Hoshino, Satoshi Takagi
Combretastatin A-4 phosphate (CA4P) selectively blocks tumor blood flow. However, the detailed mechanisms through which CA4P specifically affects tumor blood vessels are not well understood. Recent reports revealed that tumor tissue-derived endothelial cells (TECs) have various specific features in comparison with normal tissue-derived endothelial cells (NECs). Thus, abnormalities in TECs may be involved in the selective vascular blockade mechanism of CA4P. In this study, we evaluated the effects of CA4P on canine NECs and TECs using confocal microscopy...
May 13, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28525375/ros-enhance-angiogenic-properties-via-regulation-of-nrf2-in-tumor-endothelial-cells
#2
Takayuki Hojo, Nako Maishi, Alam Mohammad Towfik, Kosuke Akiyama, Noritaka Ohga, Masanobu Shindoh, Yasuhiro Hida, Kazuyuki Minowa, Toshiaki Fujisawa, Kyoko Hida
Reactive oxygen species (ROS) are unstable molecules that activate oxidative stress. Because of the insufficient blood flow in tumors, the tumor microenvironment is often exposed to hypoxic condition and nutrient deprivation, which induces ROS accumulation. We isolated tumor endothelial cells (TECs) and found that they have various abnormalities, although the underlying mechanisms are not fully understood. Here we showed that ROS were accumulated in tumor blood vessels and ROS enhanced TEC migration with upregulation of several angiogenesis related gene expressions...
May 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28516764/an-autoinhibitory-role-for-the-pleckstrin-homology-domain-of-itk-and-its-interplay-with-canonical-phospholipid-recognition
#3
Sujan Devkota, Raji E Joseph, Scott E Boyken, D Bruce Fulton, Amy H Andreotti
Pleckstrin homology (PH) domains are well known as phospholipid binding modules yet evidence is mounting that PH domain function extends beyond lipid recognition. In the current work, we characterize a protein binding function for the PH domain of Interleukin-2-inducible tyrosine kinase (ITK), an immune cell specific signaling protein that belongs to the TEC family of non-receptor tyrosine kinases. Its N-terminal Pleckstrin homology (PH) domain is a well characterized lipid-binding module that localizes ITK to the membrane via phosphatidylinositol (3,4,5)-trisphosphate (PIP3) binding...
May 18, 2017: Biochemistry
https://www.readbyqxmd.com/read/28515359/t-cell-progenitor-therapy-facilitated-thymopoiesis-depends-upon-thymic-input-and-continued-thymic-microenvironment-interaction
#4
Michelle J Smith, Dawn K Reichenbach, Sarah L Parker, Megan J Riddle, Jason Mitchell, Kevin C Osum, Mahmood Mohtashami, Heather E Stefanski, Brian T Fife, Avinash Bhandoola, Kristin A Hogquist, Georg A Holländer, Juan Carlos Zúñiga-Pflücker, Jakub Tolar, Bruce R Blazar
Infusion of in vitro-derived T cell progenitor (proT) therapy with hematopoietic stem cell transplant aids the recovery of the thymus damaged by total body irradiation. To understand the interaction between proTs and the thymic microenvironment, WT mice were lethally irradiated and given T cell-deficient (Rag1-/-) marrow with WT in vitro-generated proTs, limiting mature T cell development to infused proTs. ProTs within the host thymus led to a significant increase in thymic epithelial cells (TECs) by day 21 after transplant, increasing actively cycling TECs...
May 18, 2017: JCI Insight
https://www.readbyqxmd.com/read/28510655/mir-145-promoted-anoikis-resistance-in-tumor-endothelial-cells
#5
Kyoko Hida, Taisuke Kawamoto, Nako Maishi, Masahiro Morimoto, Kosuke Akiyama, Noritaka Ohga, Masanobu Shindoh, Nobuo Shinohara, Yasuhiro Hida
Tumor progression is dependent on tumor angiogenesis. We previously reported that the phenotype of tumor endothelial cells (TECs) is distinct from normal endothelial cells (NECs). Herein, we conducted a pathway analysis using a public TEC microarray database and identified several putative TEC-specific miRNAs. We found that miR-145 expression was upregulated in TECs and that miR-145 enhanced cell adhesion and anoikis resistance and upregulated Bcl-2 and Bcl-xl via ERK1/2in human microvascular endothelial cells...
May 16, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/28494186/small-interference-itga6-gene-targeting-in-the-human-thymic-epithelium-differentially-regulates-the-expression-of-immunological-synapse-related-genes
#6
Daiane Cristina F Golbert, Eliane Santana-Van-Vliet, Marcelo Ribeiro-Alves, Marbella Maria B da Fonsêca, Ailin Lepletier, Daniella Arêas Mendes-da-Cruz, Guilherme Loss, Vinícius Cotta-de-Almeida, Ana Tereza R Vasconcelos, Wilson Savino
The thymus supports differentiation of T cell precursors. This process requires relocation of developing thymocytes throughout multiple microenvironments of the organ, mainly with thymic epithelial cells (TEC), which control intrathymic T cell differentiation influencing the formation and maintenance of the immunological synapse. In addition to the proteins of the major histocompatibility complex (MHC), this structure is supported by several adhesion molecules. During the process of thymopoiesis, we previously showed that laminin-mediated interactions are involved in the entrance of T-cell precursors into the thymus, as well as migration of differentiating thymocytes within the organ...
May 11, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28492649/identifying-electrochemical-effects-in-a-thermal-electrochemical-co-driven-system-for-co2-capture
#7
Guang X Liu, Yun S Yu, Ying T Hong, Zao X Zhang, Jin J Wei, Geoff G X Wang
Currently, the most promising amine absorption system for CO2 capture still faces the challenges of heavy steam consumption and a high energy penalty. Thus, a new thermal-electrochemical co-driven system (TECS) for CO2 capture was developed to resolve these problems. In the TECS, unknown electrochemical behaviors are quite essential to assess the CO2 capture performance. Electrochemical experiments were designed using response surface methodology (RSM) to identify electrochemical effects. The results show that the cathode process is slow and difficult, which is the main limitation in improving the performance of the TECS...
May 11, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28488151/pollution-characteristics-and-potential-ecological-risk-assessment-of-metals-in-the-sediments-of-xiaoqing-river-jinan
#8
Fengchao Jiao, Lijun Ren, Xu Wang, Wenjie Liu
The spatial-temporal changing characteristics and potential ecological risk combined with local policies and industrial status were analyzed. The metal contamination was studied by sediment quality guidelines (SQGs), potential ecological risk index (PERI), and geoaccumulation index (I geo) of metals (Hg, Cr, Cd, As, Pb, and Cu) in the sediments of Xiaoqing River in Jinan from 1996 to 2014. Results showed that the concentrations of metals were in fluctuation and had a decreasing trend in the past 19 years, which was influenced by industry and policy...
May 10, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28485099/ectopic-bone-formation-by-aggregated-mesenchymal-stem-cells-from-bone-marrow-and-adipose-tissue-a-comparative-study
#9
Eelco M Fennema, Laurent A H Tchang, Huipin Yuan, Clemens A van Blitterswijk, Ivan Martin, Arnaud Scherberich, Jan de Boer
Tissue engineered constructs (TECs) based on spheroids of bone marrow mesenchymal stromal cells (BM-MSCs) combined with calcium phosphate (CaP) micro-particles and enveloped in a platelet-rich-plasma (PRP) hydrogel showed that aggregation of MSCs improves their ectopic bone formation potential. The stromal vascular fraction (SVF) and adipose-derived MSCs (ASCs) have been recognized as interesting MSC source for bone tissue engineering but their ectopic bone formation is limited. We investigated whether aggregation of ASCs could similarly improve ectopic bone formation by ASCs and SVF cells...
May 9, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28469775/melatonin-promoted-renal-regeneration-in-folic-acid-induced-acute-kidney-injury-via-inhibiting-nucleocytoplasmic-translocation-of-hmgb1-in-tubular-epithelial-cells
#10
Fengming Zhu, Octavia Ls Chong Lee Shin, Huzi Xu, Zhi Zhao, Guangchang Pei, Zhizhi Hu, Juan Yang, Yanchao Guo, Jingyi Mou, Jie Sun, Han Zhu, Yuxi Wang, Meng Wang, Qian Yang, Wenhui Liao, Gang Xu, Rui Zeng, Ying Yao
Melatonin (N-acetyl-5-methoxytryptamine), a circadian-regulating hormone, has been reported to exert a protective role during acute kidney injury (AKI) induced by renal ischemia-reperfusion injury (I/R). High-mobility group box 1 (HMGB1) is a novel member of the damage-associated molecular pattern (DAMP) family, and has been verified to be an inflammatory cytokine mediating AKI induced by I/R and cisplatin. However, the effect of melatonin on HMGB1, as well as the relationship of these two with folic acid induced AKI are elusive...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28467855/use-of-ice-nucleating-proteins-to-improve-the-performance-of-freeze-thaw-valves-in-microfluidic-devices
#11
Joseph C Gaiteri, W Hampton Henley, Nathan A Siegfried, Thomas H Linz, J Michael Ramsey
Currently, reliable valving on integrated microfluidic devices fabricated from rigid materials is confined to expensive and complex methods. Freeze-thaw valves (FTVs) can provide a low cost, low complexity valving mechanism, but reliable implementation of them has been greatly hindered by the lack of ice nucleation sites within the valve body's small volume. Work to date has required very low temperatures (on the order of -40 °C or colder) to induce freezing without nucleation sites, making FTVs impractical due to instrument engineering challenges...
May 11, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28455312/administration-of-rankl-boosts-thymic-regeneration-upon-bone-marrow-transplantation
#12
Noella Lopes, Hortense Vachon, Julien Marie, Magali Irla
Cytoablative treatments lead to severe damages on thymic epithelial cells (TECs), which result in delayed de novo thymopoiesis and a prolonged period of T-cell immunodeficiency. Understanding the mechanisms that govern thymic regeneration is of paramount interest for the recovery of a functional immune system notably after bone marrow transplantation (BMT). Here, we show that RANK ligand (RANKL) is upregulated in CD4(+) thymocytes and lymphoid tissue inducer (LTi) cells during the early phase of thymic regeneration...
April 28, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28454303/expression-of-er%C3%AE-gene-in-breast-carcinoma-and-the-relevance-in-neoadjuvant-therapy
#13
Jing Chang, Jihong Liu, Huiying Li, Jing Li, Yanling Mu, Bin Feng
In the present study, we examined the expression of the estrogen receptor β (ERβ) gene in breast cancer and its relevance in neoadjuvant therapy. In total, 120 breast cancer patients who were hospitalized in the Departments of Breast Disease and Medical Oncology served as the subjects of this study. The subjects were diagnosed with breast cancer phase II to phase IIIA, as confirmed by aspiration biopsy and iconography. The patients were divided into two groups in a randomized control manner, with 60 patients in each group...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28450862/differential-response-of-mouse-thymic-epithelial-cell-types-to-ionizing-radiation-induced-dna-damage
#14
Irene Calvo-Asensio, Thomas Barthlott, Lilly von Muenchow, Noel F Lowndes, Rhodri Ceredig
Thymic epithelial cells (TECs) are the main components of the thymic stroma that support and control T-cell development. Preparative regimens using DNA-damaging agents, such as total body irradiation and/or chemotherapeutic drugs, that are necessary prior to bone marrow transplantation (BMT) have profound deleterious effects on the hematopoietic system, including the thymic stroma, which may be one of the main causes for the prolonged periods of T-cell deficiency and the inefficient T cell reconstitution that are common following BMT...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28445929/the-kinesin-motor-protein-kif7-is-required-for-t-cell-development-and-normal-mhc-expression-on-thymic-epithelial-cells-tec-in-the-thymus
#15
Ching-In Lau, Alessandro Barbarulo, Anisha Solanki, José Ignacio Saldaña, Tessa Crompton
Kif7 is a ciliary kinesin motor protein that regulates mammalian Hedgehog pathway activation through influencing structure of the primary cilium. Here we show that Kif7 is required for normal T-cell development, despite the fact that T-cells lack primary cilia. Analysis of Kif7-deficient thymus showed that Kif7-deficiency increases the early CD44+CD25+CD4-CD8- thymocyte progenitor population but reduces differentiation to CD4+CD8+ double positive (DP) cell. At the transition from DP to mature T-cell, Kif7-deficiency selectively delayed maturation to the CD8 lineage...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28445634/low-temperature-associated-interface-influence-on-the-black-phosphorus-nanoflakes
#16
Peng Huang, Dan Guo, Guoxin Xie
The temperature-dependent structure properties of few-layer black phosphorus (BP) nanoflakes supported on the Si substrate and suspended on the holes are investigated using the Raman spectroscopy in the range of 77-293 K. The temperature coefficients of three main Raman modes for supported BP are larger than those of suspended BP because of the interface effects, mainly the tensile strain and the different thermal expansion coefficients (TEC) between the substrate and BP nanoflakes. The out-of-plane vibration is more apt to be affected by the initial strain, whereas the influence on the in-plane vibrations is negligible...
May 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28439878/dissecting-and-modelling-the-emergent-murine-tec-compartment-during-ontogeny
#17
Fabian Brunk, Chloé Michel, Tim Holland-Letz, Alla Slynko, Annette Kopp-Schneider, Bruno Kyewski, Sheena Pinto
The origin of the thymic epithelium, i.e. the cortical (cTEC) and medullary (mTEC) epithelial cells, from bipotent stem cells through TEC progenitors and lineage-specific progeny still remains poorly understood. We sought to obtain an unbiased view of the incipient emergence of TEC subsets by following embryonic TEC development based on co-expression of EpCAM, CD80 and MHC class II (MHCII) on non-hematopoietic (CD45(-) ) thymic stromal cells in wild-type BL6 mice. Using a combination of ex vivo analysis, Re-aggregate Thymic Organ Culture (RTOC) reconstitution assays and mathematical modelling, we traced emergent lineage commitment in murine embryonic TECs...
April 25, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28432446/biasing-spatial-attention-with-semantic-information-an-event-coding-approach
#18
Tarek Amer, Davood G Gozli, Jay Pratt
We investigated the influence of conceptual processing on visual attention from the standpoint of Theory of Event Coding (TEC). The theory makes two predictions: first, an important factor in determining the influence of event 1 on processing event 2 is whether features of event 1 are bound into a unified representation (i.e., selection or retrieval of event 1). Second, whether processing the two events facilitates or interferes with each other should depend on the extent to which their constituent features overlap...
April 21, 2017: Psychological Research
https://www.readbyqxmd.com/read/28429754/real-time-detection-of-tsunami-ionospheric-disturbances-with-a-stand-alone-gnss-receiver-a-preliminary-feasibility-demonstration
#19
Giorgio Savastano, Attila Komjathy, Olga Verkhoglyadova, Augusto Mazzoni, Mattia Crespi, Yong Wei, Anthony J Mannucci
It is well known that tsunamis can produce gravity waves that propagate up to the ionosphere generating disturbed electron densities in the E and F regions. These ionospheric disturbances can be studied in detail using ionospheric total electron content (TEC) measurements collected by continuously operating ground-based receivers from the Global Navigation Satellite Systems (GNSS). Here, we present results using a new approach, named VARION (Variometric Approach for Real-Time Ionosphere Observation), and estimate slant TEC (sTEC) variations in a real-time scenario...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28428467/effects-of-mathematical-analysis-of-test-injection-on-the-ct-value-estimation-of-the-aorta
#20
Jun Nakane, Yoshiharu Kobayashi, Tsutomu Shiozawa
The circulation time and the mechanical acceleration time (MA time) of an automatic injector were simulated using pharmacokinetic analysis. The addition method and transfer-function method, which are mathematical techniques used for analyzing the test bolus method in multi-detector computed tomography, were used to verify the accuracy of estimation of the time-enhancement curve (TEC) of the main bolus. The TEC estimated using the addition method, and the TEC of the main bolus matched completely only if the MA time of the automatic injector was set to 0 seconds...
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
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