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https://www.readbyqxmd.com/read/27922255/risk-factors-for-nocturnal-hypoxemia-in-severe-osa-patients
#1
Eric Deflandre, Damien Kempeneers, Stephanie Degey, Robert Poirrier, Pascal Legros, Jean F Brichant, Jean Joris
BACKGROUND: Severe obstructive sleep apnea (sOSA) and oxygen desaturations are both risk factors for postoperative complications. In some but not all patients, sOSA is associated with frequent oxygen desaturation episodes during sleep. The aim of this retrospective study was to identify the risk factors for exhibiting oxygen desaturation in patients with sOSA. METHODS: Records of 786 patients, mainly obese (Body Mass Index [mean + SD] = 30.2 + 6.0 kg/m2), were analyzed...
December 6, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27920586/the-relation-between-sleep-and-weight-in-a-suburban-sleep-center-observations-and-speculations-on-apnea-and-weight
#2
Robert G Hooper
STUDY OBJECTIVES: The relationship between obstructive sleep apnea (OSA) and body weight is not clearly established. In order to describe the relationship of weight and OSA severity seen in a suburban sleep center, an observational review was performed of initial diagnostic polysomnograms (PSGs) ordered on patients with American Academy of Sleep Medicine (AASM) symptomatic indications. METHODOLOGY/PRINCIPLE FINDINGS: Initial, full-night diagnostic or initial split-night (diagnostic portion) PSGs performed for any indication on patients >18 years old were retrospectively reviewed for a two year period...
2016: Nature and Science of Sleep
https://www.readbyqxmd.com/read/27908527/-historical-review-on-obstructive-sleep-apnea-in-children
#3
Y H Chien, C Guilleminault
An historical review on the discoveries on pediatric obstructive sleep apnea syndrome and sleep-disordered breathing is outlined. Starting with the description by Dickens of "Joe" the obese, snoring and sleepy individual, the authors trace more than 50 years of questions and research starting with the lean adult to the child and from the recognition of obstructive sleep apnea syndrome to the outline of upper-airway resistance syndrome. The pathophysiological knowledge on sleep-disordered breathing has evolved over time, as have treatment approaches in children, from tracheostomy to positive-airway-pressure therapy, to adenotonsillectomy with and without orthodontic treatments to oral-facial myofunctional therapy...
November 28, 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27901270/adipose-tissue-inflammation-by-intermittent-hypoxia-mechanistic-link-between-obstructive-sleep-apnoea-and-metabolic-dysfunction
#4
Silke Ryan
Obstructive sleep apnoea (OSA) is a highly prevalent condition and recognized as a major public health burden conveying a significant risk of cardiometabolic diseases and mortality. Type 2 diabetes (T2D), insulin resistance (IR) and glucose tolerance are common in subjects with OSA and this association is at least in part independent of the effects of obesity. Continuous positive airway pressure (CPAP) is the treatment of choice for the majority of patients with OSA but the benefit of CPAP on glycaemic health is uncertain...
November 29, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27901185/applicability-of-predictive-equations-for-resting-energy-expenditure-in-obese-patients-with-obstructive-sleep-apnea
#5
Mariana Pantaleão Del Re, Camila Maria de Melo, Marcus Vinicius Dos Santos, Sergio Tufik, Marco Túlio de Mello
Objective: To investigate the applicability of predictive equations for resting energy expenditure (REE) in obese individuals with obstructive sleep apnea (OSA) and the effects of OSA severity on REE. Materials and methods: Twenty-nine obese men, 41.5 ± 7 years old, with moderate and severe OSA were recruited. All subjects were submitted to a clinical polysomnography, body composition, and indirect calorimetry measurements. REE was also predicted by three different equations: Harris and Benedict (1919), Cunningham (1990), and DRI (2002)...
November 24, 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27890604/gender-dimorphism-in-pediatric-osa-is-it-for-real
#6
REVIEW
Pablo E Brockmann, Dorit Koren, Leila Kheirandish-Gozal, David Gozal
In epidemiologic studies focused on adults, obstructive sleep apnea (OSA) has higher prevalence in men than in women. The evidence supporting a gender-related discrepant prevalence of OSA is however much more tenuous in children. Here, we aimed to review the evidence concerning gender- based differences in the prevalence of OSA in children, and if so, to examine the evidence with the intent to identify potential factors that may account for this putative association. Gender-based perception and reporting of clinical manifestations of OSA may be modulated by several social and cultural factors in children...
November 23, 2016: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/27867577/when-continuous-positive-airway-pressure-cpap-fails
#7
REVIEW
Jagdeep S Virk, Bhik Kotecha
Obstructive sleep apnoea (OSA) is increasingly prevalent, particularly in the context of the obesity epidemic, and is associated with a significant social, health and economic impact. The gold standard of treatment for moderate to severe OSA is continuous positive airway pressure (CPAP). However compliance rates can be low. Methodology to improve patient tolerance to CPAP alongside with alternative, non-surgical and surgical, management strategies are discussed. All patients that fail CPAP therapy would benefit from formal upper airway evaluation by the otolaryngologist to identify any obvious causes and consider site-specific surgical therapies...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27865065/how-do-we-recognize-the-child-with-osas
#8
Koen F Joosten, Helena Larramona, Silvia Miano, Dick Van Waardenburg, Athanasios G Kaditis, Nele Vandenbussche, Refika Ersu
Obstructive sleep-disordered breathing includes a spectrum of clinical entities with variable severity ranging from primary snoring to obstructive sleep apnea syndrome (OSAS). The clinical suspicion for OSAS is most often raised by parental report of specific symptoms and/or abnormalities identified by the physical examination which predispose to upper airway obstruction (e.g., adenotonsillar hypertrophy, obesity, craniofacial abnormalities, neuromuscular disorders). Symptoms and signs of OSAS are classified into those directly related to the intermittent pharyngeal airway obstruction (e...
November 16, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27843225/glaucoma-and-its-association-with-obstructive-sleep-apnea-a-narrative-review
#9
REVIEW
Aditya Chaitanya, Vijaya H Pai, Aswini Kumar Mohapatra, Ramesh S Ve
Obstructive sleep apnea (OSA) is one of the systemic risk factors for glaucoma which causes irreversible visual field (VF) damage. We reviewed the published data of all types of studies on the association between these two conditions and papers regarding functional and structural changes related to glaucomatous damage using Scopus, web of science, and PubMed databases. There is evidence that the prevalence of glaucoma is higher in OSA patients, which independent of intraocular pressure (IOP). Studies have reported thinning of retinal nerve fiber layer (RNFL), alteration of optic nerve head, choroidal and macular thickness, and reduced VF sensitivity in patients of OSA with no history glaucoma...
September 2016: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/27827006/did-napoleon-suffer-from-chronic-rhonchopathy
#10
Claude-Henri Chouard
CONCLUSION: If Napoleon had been treated, Europa would then have doubtless been different, and perhaps would not have known the last two World wars. OBJECTIVES: This study plans to demonstrate that Napoleon very probably suffered from Chronic Rhonchopathy. BACKGROUND: Between 1983-1993, the author led their ENT department of CHU Saint-Antoine to contribute in the knowledge of chronic snoring and Obstructive Sleep Apneas Syndrome (OSAS), and to define the treatment of their consequences...
November 9, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27824596/effects-of-continuous-positive-airway-pressure-on-energy-balance-regulation-a-systematic-review
#11
REVIEW
Ari Shechter
Obesity is both a cause and a possible consequence of obstructive sleep apnoea (OSA), as OSA seems to affect parameters involved in energy balance regulation, including food intake, hormonal regulation of hunger/satiety, energy metabolism and physical activity. It is known that weight loss improves OSA, yet it remains unclear why continuous positive airway pressure (CPAP) often results in weight gain.The goal of this systematic review is to explore if and how CPAP affects the behaviour and/or metabolism involved in regulating energy balance...
December 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27823726/the-associations-between-sleep-disorders-and-anthropometric-measures-in-adults-from-three-colombian-cities-at-different-altitudes
#12
Alvaro J Ruiz, Martín A Rondon Sepúlveda, Oscar H Franco, Magda Cepeda, Patricia Hidalgo Martinez, Sandra B Amado Garzón, Edna R Salazar Ibarra, Liliana Otero Mendoza
BACKGROUND: Sleep disorders are common but underdiagnosed conditions, which are associated with obesity. In Colombia, the distribution of sleep disorders remains unclear. We aimed to describe the distribution of sleep disorders, according to demographic, geographic and anthropometric characteristics, in adult Colombian populations. METHODS: A multicenter study was conducted with 5474 participants recruited from three Colombian cities at different altitudes. A two-stage cluster sampling method was applied...
December 2016: Maturitas
https://www.readbyqxmd.com/read/27818084/obstructive-sleep-apnea-and-energy-balance-regulation-a-systematic-review
#13
REVIEW
Ari Shechter
: Obesity and obstructive sleep apnea (OSA) have a reciprocal relationship. Sleep disruptions characteristic of OSA may promote behavioral, metabolic, and/or hormonal changes favoring weight gain and/or difficulty losing weight. The regulation of energy balance (EB), i.e., the relationship between energy intake (EI) and energy expenditure (EE), is complex and multi-factorial, involving food intake, hormonal regulation of hunger/satiety/appetite, and EE via metabolism and physical activity (PA)...
July 15, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/27810258/obstructive-sleep-apnea-and-incident-type-2-diabetes
#14
Mako Nagayoshi, Naresh M Punjabi, Elizabeth Selvin, James S Pankow, Eyal Shahar, Hiroyasu Iso, Aaron R Folsom, Pamela L Lutsey
OBJECTIVES: To determine whether severity of obstructive sleep apnea is associated with incident diabetes in middle-aged and older adults. METHODS: A prospective analysis of 1453 non-diabetic participants of both the Atherosclerosis Risk in Communities Study and the Sleep Heart Health Study (mean age 63 years, 46% male) had in-home polysomnography (1996-1998) and was followed up for incident diabetes. Using the apnea-hypopnea index derived from home polysomnography, study participants were categorized as follows: <5...
September 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27792079/obesity-hypoventilation-syndrome-sleep-apnea-overlap-syndrome-perioperative-management-to-prevent-complications
#15
Raviraj Raveendran, Jean Wong, Mandeep Singh, David T Wong, Frances Chung
PURPOSE OF REVIEW: The prevalence of sleep disordered breathing (SDB) is increasing proportional to the prevalence of obesity. Although anesthesiologists are familiar with obstructive sleep apnea (OSA) - the most common SDB, anesthesiologists may not be aware of other SDB such as obesity hypoventilation syndrome (OHS) and overlap syndrome (combination of OSA and chronic obstructive pulmonary disease). The present review provides an update of information regarding the perioperative management of OHS and overlap syndrome...
October 26, 2016: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/27787950/validation-of-the-pediatric-sleep-questionnaire-in-children-with-asthma
#16
Zarmina Ehsan, Carolyn M Kercsmar, Jennifer Collins, Narong Simakajornboon
OBJECTIVE: The prevalence of obstructive sleep apnea (OSA) is higher in children with poorly controlled asthma. We aimed to determine the validity of the Pediatric Sleep Questionnaire (PSQ) to screen for OSA in children with asthma. METHODS: This retrospective review encompassed sleep studies and medical records of asthmatic children evaluated in the sleep center at CCHMC over 13 years. Measures of validity were calculated using various cut-off values for obstructive apnea-hypopnea index (OI; >1, >2, >5) and PSQ scores (>0...
October 27, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27784412/exercise-occupational-activity-and-risk-of-sleep-apnea-a-cross-sectional-study
#17
Roberto P da Silva, Denis Martinez, Martina M Pedroso, Camila G Righi, Emerson F Martins, Leticia M T Silva, Maria do Carmo S Lenz, Cintia Z Fiori
STUDY OBJECTIVE: To investigate whether structured exercise and occupational activity are associated with obstructive sleep apnea (OSA) severity. METHODS: The International Physical Activity Questionnaire was answered by 5,453 individuals who underwent full-night polysomnography. Participants were classified as exercisers or non-exercisers and also as occupationally active or non-active. The apnea-hypopnea index (AHI), minimum oxygen saturation (SaO2min), and time with saturation below 90% (TB90%) during polysomnography were used as indicators of OSA severity...
October 20, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/27779482/influence-of-premedication-with-alprazolam-on-the-occurence-of-obstructive-apneas-a-prospective-randomized-double-blind-study
#18
E Deflandre, V Bonhomme, A-C Courtois, S Degey, R Poirrier, J-F Brichant
Postoperative development or worsening of obstructive sleep apnea is a potential complication of anesthesia. The objective of this study was to study the effects of a premedication with alprazolam on the occurrence of apneas during the immediate postoperative period. Fifty ASA 1 - 2 patients undergoing a colonoscopy were recruited. Patients with a history of obstructive sleep apnea (OSA) were excluded. Recruited patients were randomly assigned to one of two groups: in Group A, they received 0.5 mg of alprazolam orally one hour before the procedure; and in Group C, they received placebo...
August 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/27771703/high-coronary-heart-disease-risk-in-hemodialysis-patients-with-central-sleep-apnea-a-pilot-study
#19
Mari Sakura, Masaaki Inaba, Koichiro Yoda, Mitsuru Ichii, Shinsuke Yamada, Tomoyuki Yamakawa, Eiji Ishimura, Senji Okuno, Shigeichi Shoji
BACKGROUND: The high prevalence of sleep apnea is reported in hemodialysis patients despite the low prevalence of obesity. The present study compared the occurrence of central sleep apnea (CSA) in hemodialysis patients with that in non-hemodialysis patients, and its association with new-onset coronary heart disease (CHD) events. METHODS: Seventy-three hemodialysis and 444 non-hemodialysis patients were examined for CSA and obstructive sleep apnea (OSA) occurrence using polysomnography...
2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27770204/overnight-changes-in-lung-function-of-obese-patients-with-obstructive-sleep-apnoea
#20
Laszlo Kunos, Zsofia Lazar, Fruzsina Martinovszky, Adam D Tarnoki, David L Tarnoki, Daniel Kovacs, Bianka Forgo, Peter Horvath, Gyorgy Losonczy, Andras Bikov
PURPOSE: Obstructive sleep apnoea (OSA) is a prevalent disorder, characterised by collapse of the upper airways during sleep. The impact of sleep-disordered breathing on pulmonary function indices is however currently not well described. The aim of the study was to evaluate diurnal change in lung function indices in a cohort of patients with OSA and relate pulmonary function changes to disease severity. METHODS: 42 patients with OSA and 73 healthy control subjects participated in the study...
October 21, 2016: Lung
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