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https://www.readbyqxmd.com/read/29775705/effects-of-different-chemical-modifications-on-the-antibacterial-activities-of-polysaccharides-sequentially-extracted-from-peony-seed-dreg
#1
Xiao-Li Li, Kiran Thakur, Yuan-Yuan Zhang, Xiao-Fang Tu, Ying-Shuo Zhang, Dan-Ye Zhu, Jian-Guo Zhang, Zhao-Jun Wei
The peony seed dreg polysaccharide (PSDPs) fractions and their modified derivatives were examined for their antibacterial potential. PSDPs along with their derivatives exhibited appreciable antibacterial activity against both Gram-positive (B. subtilis and S. aureus) as well as Gram-negative (E. coli and S. typhimurium) bacteria. Among the four polysaccharide fractions, HBSS possessed the greatest antibacterial activity with an inhibition zone of 13.6 mm against S. typhimurium, minimal inhibitory concentration of 0...
May 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29775667/identification-of-novel-hla-a11-restricted-t-cell-epitopes-in-the-ebola-virus-nucleoprotein
#2
Dan Li, Pei Li, Nianping Song, Yuting Jiang, Yang Zeng, Guangyu Zhao, Yunzhi Fa, Huahu Ye, Yuchun Lone, Yusen Zhou, Shihui Sun, Lin Zeng
The Ebola virus (EBOV) is a very contagious virus that is highly fatal in humans and animals. The largest epidemic was in West Africa in 2014, in which over 11,000 people died. However, to date, there are no licensed vaccines against it. Studies show that CD4+ and CD8+ T-cell responses, especially cytotoxic T-lymphocyte (CTL) responses, play key roles in protecting individuals from EBOV infection. Since HLA-restricted epitope vaccines are likely to be effective and safe immunization strategies for infectious diseases, the present study screened for CTL epitopes in the EBOV-nucleoprotein that are restricted by HLA-A11 (a common allele in Chinese people)...
May 15, 2018: Microbes and Infection
https://www.readbyqxmd.com/read/29775589/better-together-a-hybrid-amyloid-signals-necroptosis
#3
Dan Li, Cong Liu
A new solid-state NMR study determines the high-resolution hetero-amyloid structure of the RIPK1-RIPK3 signaling complex that is involved in mediating necroptosis. The structure demonstrates specific formation of hetero-amyloids over homo-amyloids and the structural basis for a functional amyloid to act as a platform to recruit and activate downstream partners in intracellular signaling.
May 17, 2018: Cell
https://www.readbyqxmd.com/read/29774886/-evaluation-of-inflammatory-activity-in-thyroid-associated-ophthalmopathy-by-spect-ct-with-99mtc-dtpa
#4
Dan Liu, Xueliang Xu, Dan Wen, Jia Tan, Chengzhi Jiang
To evaluate the inflammatory activity in thyroid associated ophthalmopathy (TAO) by 99mTc-diethylene triamine pentaaceticacid (99mTc-DTPA) orbital single-photon emission computed tomography (SPECT)/CT.
 Methods: A total of 48 patients were enrolled from Xiangya Hospital of Central South University between October 2016 and March 2017. According to clinical active score (CAS), 93 eyes were divided into a TAO active group (n=72) and a TAO inactive group (n=21). All patients underwent 99mTc-DTPA orbital SPECT/CT examination, and the DTPA uptake in extraocular muscle belly was supposed to be positive...
April 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29774752/effects-of-ethanol-on-the-anticancer-function-of-doxorubicin-in-jj012-cells
#5
Hui Huang, Yanze Li, Mingjuan Wu, Jing Luo, Junhui Nie, Baoyu Hou, Qi He, Yan Diao, Lin Qi, Yuanyuan Zhao, Ying Liu, Dan Yang, Lingyun Zhou
AIM: Chondrosarcoma is difficult to treat because of resistance to conventional chemotherapy and radiotherapy. This study evaluated the effects of ethanol in combination with doxorubicin in chondrosarcoma cells. MATERIALS & METHODS: JJ012, was treated with doxorubicin alone or in combination with ethanol. Effects on cellular proliferation, migration, invasion, apoptosis, and the cell cycle were evaluated. RESULTS: Treatment of JJ012 cells with 100 mM ethanol and doxorubicin resulted in reduced cell growth, invasion, and migration...
May 18, 2018: Future Oncology
https://www.readbyqxmd.com/read/29774643/a-nona-nuclear-heterometallic-pd3pt6-donut-shaped-cage-molecular-recognition-and-photocatalysis
#6
Dan Preston, Keith C Gordon, Joshua J Sutton, James D Crowley
We report a simple, low symmetry 2-(1-(pyridine-4-methyl)-1H-1,2,3-triazol-4-yl)pyridine ligand which has both monodentate and bidentate binding sites. With platinumII and/or palladiumII ions, two examples of a new nona-nuclear metallo-assembly have been accessed. These complexes have been characterized by nuclear magnetic resonance (NMR) spectroscopies, electrospray mass spectrometry (ESI-MS), and in key cases, X-ray crystallography. The cages possess three clefts comprised of planar cationic panels. This structural feature enables the binding of planar aromatic guests such as anthracene...
May 18, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29774414/tumoral-cavitation-in-colorectal-cancer-patients-with-unresectable-lung-metastasis-treated-with-bevacizumab-and-chemotherapy
#7
REVIEW
Yu Peng, Ye Chen, Xi Zhang, Yu Yang, Dan Cao, Feng Bi, Zhipi Li, Hongfeng Gou
PURPOSE: Efficacy and the frequency of tumor cavitation have not been investigated in patients with metastatic colorectal cancer (mCRC) and lung metastases (LMs) treated with chemotherapy in combination with bevacizumab. This study was aimed to evaluate the efficacy and safety of bevacizumab for unresectable mCRC with LM and to determine the frequency of tumor cavitation, and its correlation with clinical outcomes in patients receiving bevacizumab plus chemotherapy. METHODS: Patients with mCRC and LMs treated with bevacizumab as first- or second-line therapy at West China Hospital, Sichuan University Cancer Center from September 2010 to November 2016 were included in this retrospective study...
May 17, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29774182/spleen-and-splenic-vascular-involvement-in-acute-pancreatitis-an-mri-study
#8
Chao-Lian Xie, Mao Zhang, Yong Chen, Ran Hu, Meng-Yue Tang, Tian-Wu Chen, Hua-Dan Xue, Zheng-Yu Jin, Xiao-Ming Zhang
Background: To investigate the spleen and splenic vascular involvement in acute pancreatitis (AP) and their correlations with the severity of AP using magnetic resonance imaging (MRI). Methods: MRI of 239 patients with AP was retrospectively reviewed to assess splenic and splenic vascular complications, and the severity of AP. The severity of AP was graded by the MRI severity index (MRSI) and the New Revised Classification of AP 2012. The intravoxel incoherent motion (IVIM) parameters (D, D*, and f) of spleen were measured...
April 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29774069/a-large-switchable-optical-clearing-skull-window-for-cerebrovascular-imaging
#9
Chao Zhang, Wei Feng, Yanjie Zhao, Tingting Yu, Pengcheng Li, Tonghui Xu, Qingming Luo, Dan Zhu
Rationale: Intravital optical imaging is a significant method for investigating cerebrovascular structure and function. However, its imaging contrast and depth are limited by the turbid skull. Tissue optical clearing has a great potential for solving this problem. Our goal was to develop a transparent skull window, without performing a craniotomy, for use in assessing cerebrovascular structure and function. Methods: Skull optical clearing agents were topically applied to the skulls of mice to create a transparent window within 15 min...
2018: Theranostics
https://www.readbyqxmd.com/read/29773962/discovery-and-validation-of-genomic-regions-associated-with-resistance-to-maize-lethal-necrosis-in-four-biparental-populations
#10
Manje Gowda, Yoseph Beyene, Dan Makumbi, Kassa Semagn, Michael S Olsen, Jumbo M Bright, Biswanath Das, Stephen Mugo, L M Suresh, Boddupalli M Prasanna
In sub-Saharan Africa, maize is the key determinant of food security for smallholder farmers. The sudden outbreak of maize lethal necrosis (MLN) disease is seriously threatening the maize production in the region. Understanding the genetic basis of MLN resistance is crucial. In this study, we used four biparental populations applied linkage mapping and joint linkage mapping approaches to identify and validate the MLN resistance-associated genomic regions. All populations were genotyped with low to high density markers and phenotyped in multiple environments against MLN under artificial inoculation...
2018: Molecular Breeding: New Strategies in Plant Improvement
https://www.readbyqxmd.com/read/29773922/trilogy-a-planetary-geodesy-mission-concept-for-measuring-the-expansion-of-the-solar-system
#11
David E Smith, Maria T Zuber, Erwan Mazarico, Antonio Genova, Gregory A Neumann, Xiaoli Sun, Mark H Torrence, Dan-Dan Mao
The scale of the solar system is slowly changing, likely increasing as a result of solar mass loss, with additional change possible if there is a secular variation of the gravitational constant, G . The measurement of the change of scale could provide insight into the past and the future of the solar system, and in addition a better understanding of planetary motion and fundamental physics. Estimates for the expansion of the scale of the solar system are of order 1.5 cm year-1 AU-1 , which over several years is an observable quantity with present-day laser ranging systems...
April 2018: Planetary and Space Science
https://www.readbyqxmd.com/read/29773901/ets-1-promoter-associated-noncoding-rna-regulates-the-nono-erg-ets-1-axis-to-drive-gastric-cancer-progression
#12
Dan Li, Yajun Chen, Hong Mei, Wanju Jiao, Huajie Song, Lin Ye, Erhu Fang, Xiaojing Wang, Feng Yang, Kai Huang, Liduan Zheng, Qiangsong Tong
Emerging studies have indicated the essential functions of long noncoding RNAs (lncRNAs) during cancer progression. However, whether lncRNAs contribute to the upregulation of v-ets erythroblastosis virus E26 oncogene homolog 1 (Ets-1), an established oncogenic protein facilitating tumor invasion and metastasis, in gastric cancer remains elusive. Herein, we identified Ets-1 promoter-associated noncoding RNA (pancEts-1) as a novel lncRNA associated with the gastric cancer progression via mining of publicly available datasets and rapid amplification of cDNA ends...
May 18, 2018: Oncogene
https://www.readbyqxmd.com/read/29773900/c5a-induces-a549-cell-proliferation-of-non-small-cell-lung-cancer-via-gdf15-gene-activation-mediated-by-gcn5-dependent-klf5-acetylation
#13
Chenhui Zhao, Yongting Li, Wen Qiu, Fengxia He, Weiming Zhang, Dan Zhao, Zhiwei Zhang, Erbao Zhang, Pei Ma, Yiqian Liu, Ling Ma, Fengming Yang, Yingwei Wang, Yongqian Shu
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, and multiple evidence has confirmed that C5a production is elevated in NSCLC microenvironment. Although NSCLC cell proliferation induced by C5a has been reported, the involved mechanism has not been elucidated. In this study, we examined the proliferation-related genes (i.e., KLF5, GCN5, and GDF15) and C5a receptor (C5aR) expression in tumor tissues as well as C5a concentration in plasma of NSCLC patients, and then determined the roles of KLF5, GCN5, and GDF15 in C5a-triggered NSCLC cell proliferation and the related mechanism both in vitro and in vivo...
May 18, 2018: Oncogene
https://www.readbyqxmd.com/read/29773705/vapour-gas-dust-and-fume-occupational-exposures-in-male-patients-with-rheumatoid-arthritis-resident-in-cornwall-uk-and-their-association-with-rheumatoid-factor-and-anti-cyclic-protein-antibodies-a-retrospective-clinical-study
#14
Dan Murphy, Katy Bellis, David Hutchinson
OBJECTIVES: To quantify exposure to vapour, gas, dust and fumes (VGDF) and smoking in male rheumatoid arthritis (RA) and investigate impact on rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) levels. DESIGN: A retrospective observational study. SETTING: The Royal Cornwall Hospital Trust, UK. A single university hospital setting. PARTICIPANTS: 726 men followed up between February 2015 and August 2016, fulfilling RA diagnostic criteria...
May 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29773519/the-neurosteroid-allopregnanolone-sulfate-inhibits-na-v-1-3-%C3%AE-subunit-containing-voltage-gated-sodium-channels-expressed-in-xenopus-oocytes
#15
Takafumi Horishita, Nobuyuki Yanagihara, Susumu Ueno, Dan Okura, Reiko Horishita, Tomoko Minami, Yuichi Ogata, Yuka Sudo, Yasuhito Uezono, Takashi Kawasaki
The neurosteroid allopregnanolone has potent analgesic effects, and its potential use for neuropathic pain is supported by recent reports. However, the analgesic mechanisms are obscure. The voltage-gated sodium channels (Nav ) α subunit Nav 1.3 is thought to play an essential role in neuropathic pain. Here, we report the effects of allopregnanolone sulfate (APAS) on sodium currents (INa ) in Xenopus oocytes expressing Nav 1.3 with β1 or β3 subunits. APAS suppressed INa of Nav 1.3 with β1 and β3 in a concentration-dependent manner (IC50 values; 75 and 26 μmol/L)...
March 30, 2018: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29773351/correlation-between-fibrinogen-and-white-matter-hyperintensities-among-nondiabetic-individuals-with-noncardiogenic-ischemic-stroke
#16
Cheng-Jin You, Dan Liu, Li-Li Liu, Qing-Qing Liu, Guo-Zhong Li
OBJECTIVE: The aim of the present study is to confirm the correlation between fibrinogen and the severity of cerebral white matter hyperintensities (WMHs) among nondiabetic patients with noncardiogenic acute ischemic stroke. PATIENTS AND METHODS: A cross-sectional study of 170 consecutive patients with noncardiogenic acute ischemic stroke who underwent magnetic resonance imaging and vascular imaging was conducted. WMHs were classified into periventricular hyperintensity (PVH) and deep and subcortical WMH (DSWMH) using Fazekas rating scale...
May 14, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29773108/-adiponectin-inhibits-proliferation-and-induces-apoptosis-in-colorectal-cancer-hct116-cells
#17
Manling Huang, Zhitao Chen, Dan Xu, Heng Zhang, Shengbin Sun, Jie Wu
Objective To investigate the relationship between serum adiponectin level and risk of colorectal cancer, and to explore the effect of recombinant adiponectin on the proliferation and apoptosis of colorectal cancer HCT116 cells. Methods Serum adiponectin levels in patients with colorectal cancer and healthy controls were dectected by ELISA. With the level of adiponectin as a risk factor, ROC curve was acquired using SPSS software. HCT116 cells were treated with recombinant adiponectin (2.5, 5, 10, 20 μg/mL)...
March 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29772801/ogt-o-glcnac-transferase-selectively-modifies-multiple-residues-unique-to-lamin-a
#18
Dan N Simon, Amanda Wriston, Qiong Fan, Jeffrey Shabanowitz, Alyssa Florwick, Tejas Dharmaraj, Sherket B Peterson, Yosef Gruenbaum, Cathrine R Carlson, Line M Grønning-Wang, Donald F Hunt, Katherine L Wilson
The LMNA gene encodes lamins A and C with key roles in nuclear structure, signaling, gene regulation, and genome integrity. Mutations in LMNA cause over 12 diseases ('laminopathies'). Lamins A and C are identical for their first 566 residues. However, they form separate filaments in vivo, with apparently distinct roles. We report that lamin A is β- O -linked N -acetylglucosamine- (O -GlcNAc)-modified in human hepatoma (Huh7) cells and in mouse liver. In vitro assays with purified O -GlcNAc transferase (OGT) enzyme showed robust O -GlcNAcylation of recombinant mature lamin A tails (residues 385⁻646), with no detectable modification of lamin B1, lamin C, or 'progerin' (Δ50) tails...
May 17, 2018: Cells
https://www.readbyqxmd.com/read/29772575/therapeutic-effect-of-cd4-cd25-regulatory-t-cells-amplified-in-vitro-on-experimental-autoimmune-neuritis-in-rats
#19
Feng-Jie Wang, Dan Cui, Wei-Dong Qian
BACKGROUND/AIMS: This study aimed to explore whether the adoptive transfusion of autologous CD4+CD25+ regulatory T cells (CD4+CD25+ Tregs) has a therapeutic effect on Experimental autoimmune neuritis (EAN) model rats, and it provides new experimental and theoretical bases for the immunotherapy of Guillain-Barre syndrome (GBS). METHODS: CD4+CD25+ Tregs were sorted from the spleens of rats using immunomagnetic bead separation techniques combined with flow cytometry...
May 14, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29772553/establishment-of-a-porcine-model-of-indomethacin-induced-intestinal-injury
#20
Dan Yi, Wenkai Liu, Yongqing Hou, Lei Wang, Di Zhao, Tao Wu, Binying Ding, Guoyao Wu
A useful animal model of intestinal injury is pivotal for studying its pathogenesis and developing nutritional interventions (e.g., amino acid supplementation). Here, we propose the use of indomethacin (IDMT) to induce intestinal inflammation in neonatal pigs. Fourteen-day-old piglets fed a milk replacer diet receive intraperitoneal administration of IDMT (5 mg/kg body weight) for 3 consecutive days. On day 4, blood and intestinal samples are obtained for physiological and biochemical analyses. IDMT increases blood DAO activity, I-FABP concentration, neutrophil and eosinophil numbers; intestinal MMP3 mRNA levels, MPO activity, and MDA concentration; but reduces the plasma concentration of citrulline (synthesized exclusively by enterocytes of the small intestine), intestinal GSH-Px activity, and mRNA levels for villin , I-FABP , TRPV6 , AQP10 , and KCNJ13 ...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
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