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https://www.readbyqxmd.com/read/28924204/cyclipostins-and-cyclophostin-analogs-as-promising-compounds-in-the-fight-against-tuberculosis
#1
Phuong Chi Nguyen, Vincent Delorme, Anaïs Bénarouche, Benjamin P Martin, Rishi Paudel, Giri R Gnawali, Abdeldjalil Madani, Rémy Puppo, Valérie Landry, Laurent Kremer, Priscille Brodin, Christopher D Spilling, Jean-François Cavalier, Stéphane Canaan
A new class of Cyclophostin and Cyclipostins (CyC) analogs have been investigated against Mycobacterium tuberculosis H37Rv (M. tb) grown either in broth medium or inside macrophages. Our compounds displayed a diversity of action by acting either on extracellular M. tb bacterial growth only, or both intracellularly on infected macrophages as well as extracellularly on bacterial growth with very low toxicity towards host macrophages. Among the eight potential CyCs identified, CyC 17 exhibited the best extracellular antitubercular activity (MIC50 = 500 nM)...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28892202/syringomyelia-and-craniocervical-junction-abnormalities-in-chihuahuas
#2
A-M Kiviranta, C Rusbridge, O Laitinen-Vapaavuori, A Hielm-Björkman, A K Lappalainen, S P Knowler, T S Jokinen
BACKGROUND: Chiari-like malformation (CM) and syringomyelia (SM) are widely reported in Cavalier King Charles Spaniels and Griffon Bruxellois dogs. Increasing evidence indicates that CM and SM also occur in other small and toy breed dogs, such as Chihuahuas. OBJECTIVES: To describe the presence of SM and craniocervical junction (CCJ) abnormalities in Chihuahuas and to evaluate the possible association of CCJ abnormalities with SM. To describe CM/SM-related clinical signs and neurologic deficits and to investigate the association of CM/SM-related clinical signs with signalment, SM, or CCJ abnormalities...
September 11, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28879204/dynamic-susceptibility-contrast-perfusion-magnetic-resonance-imaging-demonstrates-reduced-periventricular-cerebral-blood-flow-in-dogs-with-ventriculomegaly
#3
Martin J Schmidt, Malgorzata Kolecka, Robert Kirberger, Antje Hartmann
The nature of ventriculomegaly in dogs is still a matter of debate. Signs of increased intraventricular pressure and atrophy of the cerebral white matter have been found in dogs with ventriculomegaly, which would imply increased intraventricular pressure and, therefore, a pathological condition, i.e., to some extent. Reduced periventricular blood flow was found in people with high elevated intraventricular pressure. The aim of this study was to compare periventricular brain perfusion in dogs with and without ventriculomegaly using perfusion weighted-magnetic-resonance-imaging to clarify as to whether ventriculomegaly might be associated with an increase in intraventricular pressure...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28875267/kingdom-chromista-and-its-eight-phyla-a-new-synthesis-emphasising-periplastid-protein-targeting-cytoskeletal-and-periplastid-evolution-and-ancient-divergences
#4
Thomas Cavalier-Smith
In 1981 I established kingdom Chromista, distinguished from Plantae because of its more complex chloroplast-associated membrane topology and rigid tubular multipartite ciliary hairs. Plantae originated by converting a cyanobacterium to chloroplasts with Toc/Tic translocons; most evolved cell walls early, thereby losing phagotrophy. Chromists originated by enslaving a phagocytosed red alga, surrounding plastids by two extra membranes, placing them within the endomembrane system, necessitating novel protein import machineries...
September 5, 2017: Protoplasma
https://www.readbyqxmd.com/read/28842174/a-fast-and-simple-method-for-simultaneous-measurements-of-25-oh-d-24-25-oh-2d-and-the-vitamin-d-metabolite-ratio-vmr-in-serum-samples-by-lc-ms-ms
#5
Neus Fabregat-Cabello, Jordi Farre-Segura, Loreen Huyghebaert, Stéphanie Peeters, Caroline Le Goff, Jean-Claude Souberbielle, Étienne Cavalier
BACKGROUND: Rapid, easy and reliable measurement of the major vitamin D metabolites is required in order to fulfill the needs of a clinical routine laboratory. To overcome these challenges, we have developed and validated a LC-MS/MS method for the quantification of 25-hydroxyvitamin D2 and D3, epi-25-hydroxyvitamin D3 and 24,25-dihydroxyvitamin D3. METHODS: Sample preparation was based on precipitation and centrifugation of 100μL of patient serum, followed by injection into the LC-MS/MS system...
October 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28838807/skeletal-health-in-breast-cancer-survivors
#6
REVIEW
Olivier Bruyère, Pierre Bergmann, Etienne Cavalier, Evelien Gielen, Stefan Goemaere, Jean-Marc Kaufman, Serge Rozenberg, Jean-Jacques Body
Although some risk factors for breast cancer might be protective for osteoporosis, several cross-sectional studies have reported, nevertheless, that patients with breast cancer have a lower bone mass and potentially a higher incidence of fractures than expected. In any case, it appears that patients with breast cancer are not protected from osteoporosis, which provides further support for the recommendation that bone health is assessed after a diagnosis of breast cancer. Most adjuvant therapies will lead to increased bone loss and a higher fracture rate...
August 18, 2017: Maturitas
https://www.readbyqxmd.com/read/28828394/teriflunomide-slows-bvl-in-relapsing-ms-a-reanalysis-of-the-temso-mri-data-set-using-siena
#7
Ernst-Wilhelm Radue, Till Sprenger, Laura Gaetano, Nicole Mueller-Lenke, Steve Cavalier, Karthinathan Thangavelu, Michael A Panzara, Jessica E Donaldson, Fiona M Woodward, Jens Wuerfel, Jerry S Wolinsky, Ludwig Kappos
OBJECTIVE: To assess, using structural image evaluation using normalization of atrophy (SIENA), the effect of teriflunomide, a once-daily oral immunomodulator, on brain volume loss (BVL) in patients with relapsing forms of MS enrolled in the phase 3 TEMSO study. METHODS: TEMSO MR scans were analyzed (study personnel masked to treatment allocation) using SIENA to assess brain volume changes between baseline and years 1 and 2 in patients treated with placebo or teriflunomide...
September 2017: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/28822355/baseline-assessment-of-25-hydroxyvitamin-d-assay-performance-a-vitamin-d-standardization-program-vdsp-interlaboratory-comparison-study
#8
Stephen A Wise, Karen W Phinney, Susan S-C Tai, Johanna E Camara, Gary L Myers, Ramon Durazo-Arvizu, Lu Tian, Andrew N Hoofnagle, Lorin M Bachmann, Ian S Young, Juanita Pettit, Grahame Caldwell, Andrew Liu, Stephen P J Brooks, Kurtis Sarafin, Michael Thamm, Gert B M Mensink, Markus Busch, Martina Rabenberg, Kevin D Cashman, Mairead Kiely, Michael Kinsella, Karen Galvin, Joy Y Zhang, Kyungwon Oh, Sun-Wha Lee, Chae L Jung, Lorna Cox, Gail Goldberg, Kate Guberg, Ann Prentice, Graham D Carter, Julia Jones, Patsy M Brannon, Robyn M Lucas, Peter M Crump, Etienne Cavalier, Joyce Merkel, Joseph M Betz, Christopher T Sempos
The Vitamin D Standardization Program (VDSP) coordinated an interlaboratory study to assess the comparability of measurements of total 25-hydroxyvitamin D [25(OH)D] in human serum, which is the primary marker of vitamin D status. A set of 50 individual donor samples were analyzed by 15 different laboratories representing national nutrition surveys, assay manufacturers, and clinical and/or research laboratories to provide results for total 25(OH)D using both immunoassays (IAs) and LC tandem MS (MS/MS). The results were evaluated relative to bias compared with the target values assigned based on a combination of measurements at Ghent University (Belgium) and the U...
September 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28806178/vitamin-d-and-osteosarcopenia-an-update-from-epidemiological-studies
#9
Olivier Bruyère, Etienne Cavalier, Jean-Yves Reginster
PURPOSE OF REVIEW: The review summarizes recent epidemiological studies that examined the relationship between osteoporosis and sarcopenia to assess the impact of vitamin D status or supplementation on health outcomes related to these two medical conditions. RECENT FINDINGS: Osteoporosis and sarcopenia are major public health problems, but whether these two diseases should be considered alone or combined into a single condition is not clear. No consensual definition of osteosarcopenia is largely accepted...
September 15, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/28797319/baseline-assessment-of-25-hydroxyvitamin-d-reference-material-and-proficiency-testing-external-quality-assurance-material-commutability-a-vitamin-d-standardization-program-study
#10
Karen W Phinney, Christopher T Sempos, Susan S-C Tai, Johanna E Camara, Stephen A Wise, John H Eckfeldt, Andrew N Hoofnagle, Graham D Carter, Julia Jones, Gary L Myers, Ramon Durazo-Arvizu, W Greg Miller, Lorin M Bachmann, Ian S Young, Juanita Pettit, Grahame Caldwell, Andrew Liu, Stephen P J Brooks, Kurtis Sarafin, Michael Thamm, Gert B M Mensink, Markus Busch, Martina Rabenberg, Kevin D Cashman, Mairead Kiely, Karen Galvin, Joy Y Zhang, Michael Kinsella, Kyungwon Oh, Sun-Wha Lee, Chae L Jung, Lorna Cox, Gail Goldberg, Kate Guberg, Sarah Meadows, Ann Prentice, Lu Tian, Patsy M Brannon, Robyn M Lucas, Peter M Crump, Etienne Cavalier, Joyce Merkel, Joseph M Betz
The Vitamin D Standardization Program (VDSP) coordinated a study in 2012 to assess the commutability of reference materials and proficiency testing/external quality assurance materials for total 25-hydroxyvitamin D [25(OH)D] in human serum, the primary indicator of vitamin D status. A set of 50 single-donor serum samples as well as 17 reference and proficiency testing/external quality assessment materials were analyzed by participating laboratories that used either immunoassay or LC-MS methods for total 25(OH)D...
September 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28782633/plasma-cell-deficiency-in-human-subjects-with-heterozygous-mutations-in-sec61-translocon-alpha-1-subunit-sec61a1
#11
Desirée Schubert, Marie-Christine Klein, Sarah Hassdenteufel, Andrés Caballero-Oteyza, Linlin Yang, Michele Proietti, Alla Bulashevska, Janine Kemming, Johannes Kühn, Sandra Winzer, Stephan Rusch, Manfred Fliegauf, Alejandro A Schäffer, Stefan Pfeffer, Roger Geiger, Adolfo Cavalié, Hongzhi Cao, Fang Yang, Yong Li, Marta Rizzi, Hermann Eibel, Robin Kobbe, Amy L Marks, Brian P Peppers, Robert W Hostoffer, Jennifer M Puck, Richard Zimmermann, Bodo Grimbacher
BACKGROUND: Primary antibody deficiencies (PADs) are the most frequent primary immunodeficiencies in human subjects. The genetic causes of PADs are largely unknown. Sec61 translocon alpha 1 subunit (SEC61A1) is the major subunit of the Sec61 complex, which is the main polypeptide-conducting channel in the endoplasmic reticulum membrane. SEC61A1 is a target gene of spliced X-box binding protein 1 and strongly induced during plasma cell (PC) differentiation. OBJECTIVE: We identified a novel genetic defect and studied its pathologic mechanism in 11 patients from 2 unrelated families with PADs...
August 4, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28766476/general-steps-to-standardize-the-laboratory-measurement-of-serum-total-25-hydroxyvitamin-d
#12
Christopher T Sempos, Joseph M Betz, Johanna E Camara, Graham D Carter, Etienne Cavalier, Michael W Clarke, Kirsten G Dowling, Ramon A Durazo-Arvizu, Andrew N Hoofnagle, Andy Liu, Karen W Phinney, Kurtis Sarafin, Stephen A Wise, Paul M Coates
The Vitamin D Standardization Program (VDSP) has collaborated with numerous groups and agencies to assemble a set of tools, i.e., a reference measurement system, that can be used to establish the traceability of 25-hydroxyvitamin D [25(OH)D] assays to relevant reference measurement procedures and reference materials. This is done with the goal of verifying end-user laboratory performance using precise statistical criteria to determine whether a specific assay is standardized. The purpose of this paper was to outline a set of steps that routine clinical and research laboratories can use to standardize their 25(OH)D assays using these tools...
September 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28762084/anatomy-and-histology-of-the-scrotal-ligament-in-adults-inconsistency-and-variability-of-the-gubernaculum-testis
#13
G Cavalie, Alexandre Bellier, G Marnas, B Boisson, Y Robert, P Y Rabattu, P Chaffanjon
PURPOSE: The anatomy of gubernaculum testis (GT) is often discussed; however, the postnatal anatomy of the GT or scrotal ligament (SL) is rarely described. Hence, we performed an anatomical and histological study to analyze histologically the structures between testis and scrotum. METHODS: We performed anatomical dissections on 25 human fresh cadavers' testes. Each testis was removed with its envelopes and macroscopically analyzed. Then samples were included for histological study...
July 31, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28761972/evaluation-of-a-new-fully-automated-assay-for-plasma-intact-fgf23
#14
Jean-Claude Souberbielle, Dominique Prié, Marie-Liesse Piketty, Anya Rothenbuhler, Pierre Delanaye, Philippe Chanson, Etienne Cavalier
Several FGF23 immunoassays are available. However, they are reserved for research purposes as none have been approved for clinical use. We evaluated the performances of a new automated assay for intact FGF23 on the DiaSorin Liaison platform which is approved for clinical use. We established reference values in 908 healthy French subjects aged 18-89 years, and measured iFGF23 in patients with disorders of phosphate metabolism and in patients with chronic kidney disease (CKD). Intra-assay CV was 1.04-2.86% and inter-assay CV was 4...
July 31, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28726244/computed-tomographic-morphometry-of-tympanic-bulla-shape-and-position-in-brachycephalic-and-mesaticephalic-dog-breeds
#15
Ben Mielke, Richard Lam, Gert Ter Haar
Anatomic variations in skull morphology have been previously described for brachycephalic dogs; however there is little published information on interbreed variations in tympanic bulla morphology. This retrospective observational study aimed to (1) provide detailed descriptions of the computed tomographic (CT) morphology of tympanic bullae in a sample of dogs representing four brachycephalic breeds (Pugs, French Bulldogs, English Bulldog, and Cavalier King Charles Spaniels) versus two mesaticephalic breeds (Labrador retrievers and Jack Russell Terriers); and (2) test associations between tympanic bulla morphology and presence of middle ear effusion...
July 20, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28718005/sunscreens-block-cutaneous-vitamin-d-production-with-only-a-minimal-effect-on-circulating-25-hydroxyvitamin-d
#16
Florence Libon, Justine Courtois, Caroline Le Goff, Pierre Lukas, Neus Fabregat-Cabello, Laurence Seidel, Etienne Cavalier, Arjen F Nikkels
A 50+ SPF sunscreen decreased significantly cutaneous vitamin D production following a single narrow-band (nb)UVB exposure, independently from the body surface area exposed. In contrast, the circulating 25(OH)D3 levels were only minimally affected. It is probable that another endogenous source of precursors is selected when skin-originated precursors are lacking. PURPOSE: Sunscreen use, highly advocated for preventing cutaneous carcinogenesis, is potentially leading to an aggravation of vitamin D deficiency with its consequences on bone health...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28706827/surgical-technique-for-arthroscopic-resection-of-painful-bipartite-patella
#17
Thais D Vieira, Mathieu Thaunat, Adnan Saithna, Olivier Carnesecchi, Eric Choudja, Maxime Cavalier, Jose Roberto Benites Vendrame, Andrew Charles Ockuly, Bertrand Sonnery-Cottet
Bipartite patella (BP) is uncommon and is usually an incidental finding. Painful BP occurs rarely and is usually associated with post-traumatic anterior knee pain. When nonoperative treatment fails, fragment resection is indicated. A systematic review shows a potentially increased risk of complications with open surgery. The purpose of this Technical Note is to demonstrate a simple arthroscopic technique for treating painful BP through resection of the bone fragment.
June 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28695239/occurrence-of-clinical-bone-fracture-following-a-prolonged-stay-in-intensive-care-unit-a-retrospective-controlled-study
#18
Anne-Françoise Rousseau, Etienne Cavalier, Jean-Yves Reginster, Pierre Damas, Olivier Bruyère
Clinical consequences of critical illness and critical care (CC) on bone health remain largely unexplored. This retrospective study aimed to assess the number of new bone fractures (BF) following a prolonged length of stay (LOS) in intensive care unit (ICU). Adults admitted in our tertiary ICU during 2013 with a stay >7 days were included (CC group). Patients who died in ICU or lost to follow-up were excluded. For each CC patient still alive after 2 years of follow-up, 2 control patients, scheduled for surgery during 2013, were recruited and matched for gender and age...
July 10, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28665564/-current-treatment-strategy-of-meniscal-lesions-in-athletes
#19
Philippe M Tscholl, Victoria B Duthon, Maxime Cavalier, Jacques Menetrey
The primary goal of meniscal treatment in elite athletes is to guarantee knee function for sports performance and to prevent osteoarthritic changes. The meniscus acts not only as cushion in the femorotibial joint but also as a major secondary stabilizer with its posterior medial and lateral horns. Therefore, the integrity of the meniscal tissue is crucial for knee function and needs to be preserved, especially when the meniscal lesion is found in the periphery (vascularized zone). For ideal tissue healing, a stable knee is prerequisite...
July 13, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28630713/corneal-ulcerative-disease-in-dogs-under-primary-veterinary-care-in-england-epidemiology-and-clinical-management
#20
Dan G O'Neill, Monica M Lee, Dave C Brodbelt, David B Church, Rick F Sanchez
BACKGROUND: Corneal ulcerative disease (CUD) has the potential to adversely affect animal welfare by interfering with vision and causing pain. The study aimed to investigate for the first time the prevalence, breed-based risk factors and clinical management of CUD in the general population of dogs under primary veterinary care in England. RESULTS: Of 104,233 dogs attending 110 clinics participating within the VetCompass Programme from January 1(st) to December 31(st) 2013, there were 834 confirmed CUD cases (prevalence: 0...
2017: Canine Genetics and Epidemiology
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