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Nicolas Gendron, Candice Cavalie, Elie Kantor, Sophie Provenchère, Romain Sonneville, Vasiliki Gkalea, Marie-Charlotte Bourrienne, Dorothée Faille, Nadine Ajzenberg
Therapeutic plasma exchange (TPE) has been proposed to remove heparin-induced thrombocytopenia (HIT) antibodies before planned thoracic surgery in patients with acute HIT and to allow brief re-exposure to heparin during surgery. In patients on extracorporeal membrane oxygenation (ECMO), simultaneous administration of TPE and alternative nonheparin anticoagulant therapies is challenging. We report 2 patients on ECMO with acute HIT who underwent repeated TPE to enable cardiothoracic surgery with the use of heparin...
January 2024: TH Open: Companion Journal to Thrombosis and Haemostasis
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JOURNAL ARTICLE
Valérie Chetboul, Camille Poissonnier, Pierre Foulex, Maria Paz Alvarado, Émilie Trehiou-Sechi, Vittorio Saponaro, Peggy Passavin, Loïc Desquilbet
INTRODUCTION: Degenerative mitral valve disease (DMVD) is the most common canine heart disease with a high predisposition in Cavalier King Charles Spaniels (CKCSs). Mitral regurgitation related to DMVD can lead to left atrial (LA) dilation, which is associated with survival time. Left-atrial-to-aortic (LA:Ao) ratio assessed by two-dimensional echocardiography is commonly used to evaluate LA size. The objectives of this prospective observational study were therefore 1) to compare different echocardiographic methods (i...
2024: PloS One
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JOURNAL ARTICLE
Agathe Bikupe Nkoy, Therance Tobo Matoka, Justine Busanga Bukabau, Ernest Kiswaya Sumaili, Veerle Labarque, Lambertus P van den Heuvel, Elena Levtchenko, Etienne Cavalier, Pierre Delanaye, Pépé Mfutu Ekulu, Hans Pottel
BACKGROUND: The Schwartz equation is the most widely used serum creatinine (SCr)-based formula to estimate the glomerular filtration rate (GFR) in children of European descent, but whether this applies to African children is unclear. METHODS: In a cross-sectional study, 513 apparently healthy African children aged 6 to 16 years were randomly recruited in school area of Kinshasa, the Democratic Republic of Congo (DRC). SCr was measured using calibrated enzymatic method...
March 28, 2024: Pediatric Nephrology
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JOURNAL ARTICLE
Muhammad Hudhud, Scott Proescholdbell, Tammy Norwood, Crystal Cavalier-Keck, Ronny A Bell
Like other minoritized populations, American Indian/Alaska Native (AI/AN) females experience disparate morbidity and mortality outcomes to that of the general US population. This study identified discrepancies in reporting of AI/AN female decedents between the North Carolina Violent Death Reporting System (NC-VDRS) and an online, user-generated database. Female AI/AN decedent data of all ages were collected from the NC-VDRS and compared against that of the publicly available North Carolina Missing and Murdered Indigenous Women (MMIW NC) database for the study period, 2004-2019...
March 2024: Forensic Sciences Research
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JOURNAL ARTICLE
Emily L Coffey, Liang Ma, Ousmane H Cissé, Joseph A Kovacs, Katie M Minor, Antti Sukura, Patrizia Danesi, Steven G Friedenberg, Jonah N Cullen, Christiane Weissenbacher-Lang, Julie C Nadeau, Amber M Graham, Martin N Granick, Natalie K Branson, Kyle C Branson, Barbara Blasi, Casandra M Jacobs, Eva Furrow
Pet dogs are a valuable natural animal model for studying relationships between primary immunodeficiencies and susceptibility to Pneumocystis and other opportunistic respiratory pathogens. Certain breeds, such as the Cavalier King Charles Spaniel, are over-represented for Pneumocystis pneumonia (PCP), suggesting the presence of a primary immunodeficiency in the breed. Here, we report the discovery of a CARMIL2 nonsense variant in three Cavalier King Charles Spaniel dogs with either PCP (n = 2) or refractory Bordetella pneumonia (n = 1)...
March 5, 2024: Journal of Fungi (Basel, Switzerland)
#6
JOURNAL ARTICLE
Marjorie Millet, Maxime Auroux, Charlotte Beaudart, Céline Demonceau, Aurélie Ladang, Etienne Cavalier, Jean-Yves Reginster, Olivier Bruyère, Roland Chapurlat, Jean-Charles Rousseau
OBJECTIVE: To identify a microRNA signature associated to sarcopenia in community-dwelling older adults form the SarcoPhAge cohort. METHODS: In a screening phase by next generation sequencing (NGS), we compared the hsa-miRome expression of 18 subjects with sarcopenia (79.6 ± 6.8 years, 9 men) and 19 healthy subjects without sarcopenia (77.1 ± 6 years, 9 men) at baseline. Thereafter, we have selected eight candidate hsa-miRNAs according to the NGS results and after a critical assessment of previous literature...
March 14, 2024: Aging Clinical and Experimental Research
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JOURNAL ARTICLE
Sophie Vieujean, Romain Gillard, Pierre Delanaye, Laurence Seidel, Emeline Bequet, Catherine Salée, Marie-Alice Meuwis, Charlotte Massot, Nicolas Pierre, Paul Meunier, Etienne Cavalier, Edouard Louis
BACKGROUND: The inactive dephosphorylated and uncarboxylated form of the matrix Gla protein (dp-ucMGP) has been shown to be increased in plasma of inflammatory bowel disease (IBD) patients. Our aim was to assess if the plasmatic level of dp-ucMGP could reflect disease endoscopic activity, presence of strictures and cumulative structural bowel damage in Crohn's disease (CD) patients. METHODS: The plasmatic level of dp-ucMGP was measured in a monocentric cohort of prospectively recruited patients...
March 2024: Scandinavian Journal of Gastroenterology
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JOURNAL ARTICLE
Maiken B T Bach, Camilla L Stougaard, Maria S Thøfner, Maria J Reimann, Ulrik Westrup, Jørgen Koch, Merete Fredholm, Torben Martinussen, Mette Berendt, Lisbeth H Olsen
BACKGROUND: Syringomyelia (SM) and myxomatous mitral valve disease (MMVD) are highly prevalent in Cavalier King Charles spaniels (CKCS). Cardiac status in CKCS with and without SM is currently unknown. OBJECTIVES: To investigate the association between SM and MMVD severity in CKCS and CKCS with SM with and without clinical signs of SM. ANIMALS: Fifty-five CKCS: 40 with SM (22 symptomatic and 18 asymptomatic) and 15 without SM. METHODS: A combined retrospective and prospective study...
February 23, 2024: Journal of Veterinary Internal Medicine
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REVIEW
Angèle Lucas, Alastair J Noyce, Emeline Gernez, Joe M El Khoury, Guillaume Garcon, Etienne Cavalier, Sébastien Antherieu, Guillaume Grzych
Recreational use of nitrous oxide (N2 O) has become a major health issue worldwide, with a high number of clinical events, especially in neurology and cardiology. It is essential to be able to detect and monitor N2 O abuse to provide effective care and follow-up to these patients. Current recommendations for detecting N2 O in cases of recreational misuse and consumption markers are lacking. We aimed to update current knowledge through a review of the literature on N2 O measurement and kinetics. We reviewed the outcomes of experiments, whether in preclinical models ( in vitro or in vivo ), or in humans, with the aim to identify biomarkers of intoxication as well as biomarkers of clinical severity, for laboratory use...
February 21, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
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JOURNAL ARTICLE
Charlie Tewson, Simone Kirby
This case study describes the diagnosis and treatment of a deciduous left maxillary canine tooth root that had been displaced into the pulp of the developing permanent left maxillary canine tooth in a 23-month-old female neutered Cavalier King Charles Spaniel. The patient was initially presented for bilateral persistent deciduous maxillary canine teeth extraction. Seventeen months later the permanent left maxillary canine tooth was found to be non-vital and tooth development had ceased prior to apical closure...
February 19, 2024: Journal of Veterinary Dentistry
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JOURNAL ARTICLE
Citlalli Limpens, Vivian T M Smits, Hille Fieten, Paul J J Mandigers
INTRODUCTION: Syringomyelia (SM) is a heritable disorder causing a fluid filled cavity (FFC) in the spinal cord with a reported overall prevalence of 39 to 46% in the Cavalier King Charles Spaniels (CKCS). Breeders started screening their CKCS with MRI in the Netherlands since 2004 and in Denmark since 2015. The goal of this study was to evaluate the effect of MRI-based selection in breeding on the prevalence of SM. METHOD: MRI scans of 2,125 purebred CKCS were available...
2024: Frontiers in Veterinary Science
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JOURNAL ARTICLE
Shadi Yaghi, Liqi Shu, Daniel M Mandel, Christopher R Leon Guerrero, Nils Henninger, Jayachandra Muppa, Muhammad Affan, Omair Ul Haq Lodhi, Mirjam R Heldner, Kateryna Antonenko, David J Seiffge, Marcel Arnold, Setareh Salehi Omran, Ross Curtiss Crandall, Evan Lester, Diego Lopez Mena, Antonio Arauz, Ahmad Nehme, Marion Boulanger, Emmanuel Touzé, João André Sousa, Joao Sargento-Freitas, Vasco Barata, Paulo Castro-Chaves, Maria Teresa Álvares Pereira Brito, Muhib Khan, Dania Mallick, Aaron Rothstein, Ossama Khazaal, Josefin Kaufmann, Stefan T Engelter, Christopher Traenka, Diana Aguiar de Sousa, Mafalda Soares, Sara Db Rosa, Lily W Zhou, Preet Gandhi, Thalia S Field, Steven Mancini, Issa Metanis, Ronen R Leker, Kelly Pan, Vishnu Dantu, Karl Viktor Baumgartner, Tina M Burton, Regina Freiin von Rennenberg, Christian H Nolte, Richard K Choi, Jason A MacDonald, Reza Bavarsad Shahripour, Xiaofan Guo, Malik Ghannam, Mohammad AlMajali, Edgar A Samaniego, Sebastian Sanchez, Bastien Rioux, Faycal Zine-Eddine, Alexandre Y Poppe, Ana Catarina Fonseca, Maria Baptista, Diana Cruz, Michele Romoli, Giovanna De Marco, Marco Longoni, Zafer Keser, Kim J Griffin, Lindsey Kuohn, Jennifer A Frontera, Jordan Amar, James A Giles, Marialuisa Zedde, Rosario Pascarella, Ilaria Grisendi, Hipólito Nzwalo, David S Liebeskind, Amir M Molaie, Annie Cavalier, Wayneho Kam, Brian Mac Grory, Sami Al Kasab, Mohammad Anadani, Kimberly P Kicielinski, Ali Rada Eltatawy, Lina M Chervak, Roberto Chulluncuy-Rivas, Yasmin Ninette Aziz, Ekaterina Bakradze, Thanh Lam Tran, Marc Rodrigo-Gisbert, Manuel Requena, Faddi Ghassan Saleh Velez, Jorge G Ortiz Garcia, Varsha Muddasani, Adam de Havenon, Venugopalan Y Vishnu, Sridhara S Yaddanapudi, Latasha Adams, Abigail Browngoehl, Tamra Ranasinghe, Randy Dunston, Zachary Lynch, Mary Penckofer, James E Siegler, Silvia V Mayer, Joshua Z Willey, Adeel S Zubair, Yee Kuang Cheng, Richa Sharma, João Pedro Marto, Vitor Mendes Ferreira, Piers Klein, Thanh N Nguyen, Syed Daniyal Asad, Zoha Sarwat, Anvesh Balabhadra, Shivam Patel, Thais Leite Secchi, Sheila Co Martins, Gabriel Paulo Mantovani, Young Dae Kim, Balaji Krishnaiah, Cheran Elangovan, Sivani Lingam, Abid Y Qureshi, Sebastian Fridman, Alonso Alvarado-Bolaños, Farid Khasiyev, Guillermo Linares, Marina Mannino, Valeria Terruso, Sofia Vassilopoulou, Vasileios Tentolouris-Piperas, Manuel Martínez-Marino, Víctor A Carrasco Wall, Fransisca Indraswari, Sleiman El Jamal, Shilin Liu, Muhammad Alvi, Farman Ali, Mohammed Madani Sarvath, Rami Z Morsi, Tareq Kass-Hout, Feina Shi, Jinhua Zhang, Dilraj Sokhi, Jamil Said, Alexis N Simpkins, Roberto Gomez, Shayak Sen, Mohammad Ravi Ghani, Marwa Elnazeir, Han Xiao, Narendra Sharma Kala, Farhan Khan, Christoph Stretz, Nahid Mohammadzadeh, Eric D Goldstein, Karen L Furie
Background: Small, randomized trials of cervical artery dissection (CAD) patients showed conflicting results regarding optimal stroke prevention strategies. We aimed to compare outcomes in patients with CAD treated with antiplatelets versus anticoagulation. Methods: This is a multi-center observational retrospective international study (16 countries, 63 sites) that included CAD patients without major trauma. The exposure was antithrombotic treatment type (anticoagulation vs. antiplatelets) and outcomes were subsequent ischemic stroke and major hemorrhage (intracranial or extracranial hemorrhage)...
February 9, 2024: Stroke; a Journal of Cerebral Circulation
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JOURNAL ARTICLE
Tenna Remler Pedersen, Maiken Bayer Thode Bach, Camilla Løkke Stougaard, Hanne Gredal, Clare Rusbridge, Nanna Brix Finnerup, Mette Berendt
BACKGROUND: Syringomyelia (SM) is a prevalent inherited developmental condition in Cavalier King Charles Spaniels (CKCSs) with Chiari-like malformation (CM), accompanied by a variety of clinical manifestations, including signs of neuropathic pain. Magnetic resonance imaging (MRI) is the gold standard in SM diagnosis. However, it is desirable to establish clinical predictors that can identify CKCSs with a large clinical syrinx that needs treatment, as some owners cannot afford or lack access to MRI...
February 8, 2024: Acta Veterinaria Scandinavica
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JOURNAL ARTICLE
Ellen Davis, Elizabeth Townsend, Aero Cavalier, Yi-Fan Chen, Dameka Edwards-Hart, Spyros Kitsiou, Wiktoria Kowalczyk, Iliana Mansur, Ebere Okpara, Karen Powell, Valerie G Press, Toni Ramirez, Deborah Salvo, Lisa K Sharp, Brittani Wright, Sharmilee Maria Nyenhuis
BACKGROUND: Black women experience a higher prevalence of poor asthma outcomes and physical inactivity than their White counterparts. Black women comprise a particularly vulnerable group of patients with asthma, with some of the highest rates of asthma in adults, high health care use (emergency department visits and hospitalizations), and the highest crude asthma mortality rate of all race or ethnicity groups. Despite recommendations to engage in regular physical activity, fewer than 15% of Black women meet the 2008 National Physical Activity Guidelines, the lowest of all racial subgroups of adults...
February 7, 2024: JMIR Research Protocols
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JOURNAL ARTICLE
Magali Casanova, Marc Maresca, Isabelle Poncin, Vanessa Point, Hamza Olleik, Céline Boidin-Wichlacz, Aurélie Tasiemski, Kamel Mabrouk, Jean-François Cavalier, Stéphane Canaan
BACKGROUND: Mycobacterium abscessus, a fast-growing non-tuberculous mycobacterium, is an emerging opportunistic pathogen responsible for chronic bronchopulmonary infections in people with respiratory diseases such as cystic fibrosis (CF). Due to its intrinsic polyresistance to a wide range of antibiotics, most treatments for M. abscessus pulmonary infections are poorly effective. In this context, antimicrobial peptides (AMPs) active against bacterial strains and less prompt to cause resistance, represent a good alternative to conventional antibiotics...
January 29, 2024: Journal of Biomedical Science
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JOURNAL ARTICLE
Yosuke Nakagawa, Hirotaka Komaba
Parathyroid hormone measurement is critical in managing chronic kidney disease-mineral bone disorders. However, there are several commercially available immunoassays with interassay variability. To address this, Cavalier et al. developed standardization of parathyroid hormone measurement by establishing regression equations of each assay against the liquid chromatography coupled to tandem mass spectrometry method. The recalibration successfully reduced interassay variability, allowing for more consistent interpretation...
February 2024: Kidney International
#17
JOURNAL ARTICLE
Abdulfataah A A Mohamed, Arend Bökenkamp, Etienne Cavalier, Pierre Delanaye, Natalie Ebert, Marco van Londen
No abstract text is available yet for this article.
January 16, 2024: Nephrology, Dialysis, Transplantation
#18
REVIEW
Pierre Delanaye, Etienne Cavalier, Thomas Stehlé, Hans Pottel
BACKGROUND: In daily practice, glomerular filtration rate (GFR) is estimated with equations including renal biomarkers. Among these biomarkers, serum creatinine remains the most used. However, there are many limitations with serum creatinine we will discuss in the current review. We will also discuss how creatinine-based equations have been developed and what we can expect from them in terms of performance to estimate GFR. SUMMARY: Different creatinine-based equations have been proposed...
January 12, 2024: Nephron
#19
REVIEW
Pawel Kiper, Nathalie Godart, Manon Cavalier, Charlotte Berard, Błażej Cieślik, Sara Federico, Aleksandra Kiper, Leonardo Pellicciari, Roberto Meroni
Virtual reality (VR) is an innovative rehabilitation tool increasingly used in stroke rehabilitation. Fully immersive VR is a type of VR that closely simulates real-life scenarios, providing a high level of immersion, and has shown promising results in improving rehabilitation functions. This study aimed to assess the effect of immersive VR-based therapy for stroke patients on the upper extremities, activities of daily living (ADLs), and pain reduction and its acceptability and side effects. For this review, we gathered all suitable randomized controlled trials from PubMed, EMBASE, Cochrane Library, Scopus, and Web of Science...
December 27, 2023: Journal of Clinical Medicine
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JOURNAL ARTICLE
Jiwon Lee, Xiangning Xue, Emily Au, William B McIntyre, Roshanak Asgariroozbehani, Kristoffer Panganiban, George C Tseng, Maria Papoulias, Emily Smith, Jonathan Monteiro, Divia Shah, Kateryna Maksyutynska, Samantha Cavalier, Emril Radoncic, Femin Prasad, Sri Mahavir Agarwal, Robert Mccullumsmith, Zachary Freyberg, Ryan W Logan, Margaret K Hahn
Antipsychotic (AP)-naive first-episode psychosis (FEP) patients display early dysglycemia, including insulin resistance and prediabetes. Metabolic dysregulation may therefore be intrinsic to psychosis spectrum disorders (PSDs), independent of the metabolic effects of APs. However, the potential biological pathways that overlap between PSDs and dysglycemic states remain to be identified. Using meta-analytic approaches of transcriptomic datasets, we investigated whether AP-naive FEP patients share overlapping gene expression signatures with non-psychiatrically ill early dysglycemia individuals...
January 10, 2024: Translational Psychiatry
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