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Post Thrombotic Syndrome

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https://www.readbyqxmd.com/read/28303518/potentially-life-threatening-coagulopathy-associated-with-simultaneous-reduction-in-coagulation-and-fibrinolytic-function-in-pediatric-acute-leukemia-after-hematopoietic-stem-cell-transplantation
#1
Takashi Ishihara, Keiji Nogami, Tomoko Matsumoto, Akitaka Nomura, Yasufumi Takeshita, Satoshi Ochi, Midori Shima
The pathogenesis of sinusoidal obstruction syndrome (SOS) and thrombotic microangiopathy (TMA) after hematopoietic stem cell transplantation (HSCT) is poorly understood, and limited information is available on global hemostatic function in HSCT. We assessed changes in coagulation and fibrinolysis using a simultaneous thrombin and plasmin generation assay (T/P-GA) during HSCT. Measurements of endogenous thrombin potential (T-EP) and plasmin peak height (P-Peak) using T/P-GA in six pediatric acute leukemia patients treated with HSCT were compared to normal plasma...
March 16, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28291305/comparison-of-clinical-outcomes-of-pharmacomechanical-thrombectomy-in-iliac-vein-thrombosis-with-and-without-may-thurner-syndrome
#2
In-Sub Kim, Won-Min Jo, Hwan-Hoon Chung, Seung-Hwa Lee
BACKGROUND: May-Thurner syndrome (MTS) has a different etiology from that of general deep vein thrombosis (DVT). However, few clinical comparisons of MTS-induced and non-MTS- induced DVT have been reported. The aim of this study was to analyze the clinical results of pharmacomechanical thrombectomy (PMT) in DVT with and without MTS. METHODS: Forty-seven iliac-vein thrombosis patients treated with PMT between January 2008 and December 2013 were enrolled. 25 patients had DVT with MTS and 22 patients had iliac vein DVT without MTS...
March 14, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28257912/warfarin-associated-venous-limb-gangrene-in-cancer-related-dvt-case-report
#3
Vladimir Cojocari, Dumitru Casian, Eugen Gutu
INTRODUCTION: Warfarin anticoagulation of oncologic patients with DVT may paradoxically progress to phlegmasia cerulea dolens and limb gangrene, due to cancer-associated disseminated intravascular coagulation. This case report, written in line with the SCARE criteria, endorses venous thrombectomy in selected patients to attempt limb salvage. A young woman's warfarin associated acute ileofemoral phlegmasia that developed over cervical cancer radiation therapy induced DVT, was successfully resolved by clot removal...
January 23, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28249878/immune-complexes-of-beta-2-glicoprotein-i-bounded-to-iga-a-novel-marker-able-to-predict-thrombosis-after-renal-transplantation-in-patients-with-antiphospholipid-antibodies
#4
Manuel Serrano, José A Martínez-Flores, Dolores Pérez, Florencio García, Oscar Cabrera-Marante, Daniel E Pleguezuelo, Estela Paz-Artal, José M Morales, Esther González, Antonio Serrano
Background -Antiphospholipid syndrome (APS) is characterized by recurrent thrombosis and/or gestational morbidity in patients with antiphospholipid autoantibodies (aPL). Predictive value of the presence of aPL is low and new markers are necessary to identify aPL carriers at higher risk and take preventive measures on them.The presence of circulating immune complexes of IgA bound to Beta2-glycoprotein-I (B2A-CIC) has been associated with occurrence of acute thrombotic events (TEV). In this work we study its possible predictive value for appearance of TEV in patients who are going to undergo transplant surgery, a well-known trigger of TEV in aPL carriers 94...
March 1, 2017: Circulation
https://www.readbyqxmd.com/read/28249199/venous-thrombosis-in-children-and-adolescents-with-hodgkin-lymphoma-in-sweden
#5
A Schönning, J Karlén, T Frisk, M Heyman, J E Svahn, I Øra, L Kawan, B-M Holmqvist, C Björklund, A Harila-Saari, S Ranta
INTRODUCTION: Pediatric patients with Hodgkin lymphoma (HL) have several risk factors for venous thromboembolism (VTE). Although these patients are occasionally treated with thromboprophylaxis, no guidelines are implemented in Sweden. Scarce data from adult patients indicate an increased risk of VTE, but pediatric data is largely missing. Given the favorable overall survival of HL, there should reasonably be more focus on preventing complications. MATERIALS AND METHODS: We conducted a retrospective cohort study, including all patients registered in the Childhood Cancer Registry under the age of 18years diagnosed with HL between January 2005 and December 2015 in Sweden...
February 16, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28247824/long-term-follow-up-of-endo-vascular-recanalization-of-chronic-inferior-vena-cava-occlusion-secondary-to-inferior-vena-cava-filters
#6
Sasan Partovi, Sanjeeva P Kalva, T Gregory Walker, Sabir M Taj, Suvranu Ganguli
BACKGROUND: The long term efficacy of endovascular recanalization for chronic iliocaval occlusion secondary to inferior vena cava (IVC) filters is unknown. The purpose of this study was to evaluate the effectiveness of endovascular recanalization and stent placement across the filter in patients with filter-associated chronic iliocaval occlusion. PATIENTS AND METHODS: Seven patients (mean age 56 ± 15 yrs; seven males) with symptomatic chronic iliocaval occlusion and occluded IVC filter were included...
March 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28221670/endophlebectomy-of-the-common-femoral-vein-and-arteriovenous-fistula-creation-as-adjuncts-to-venous-stenting-for-post-thrombotic-syndrome
#7
M A F de Wolf, H Jalaie, J H H van Laanen, R L M Kurstjens, M J S Mensinck, M J de Geus, A Gombert, R de Graaf, C H A Wittens
BACKGROUND: Good results have been reported for angioplasty and stenting of post-thrombotic lesions of the iliac and proximal femoral veins. If lesions at the origin of the superficial femoral and profunda veins are stented, the intraluminal synechiae can be pushed against the orifices of inflow vessels, potentially decreasing stent inflow. Surgical disobliteration of the common femoral vein (endophlebectomy) has been suggested to mitigate this problem. Because of a temporary increase in thrombogenicity, this procedure may be accompanied by arteriovenous fistula creation...
February 21, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28219192/-efficacy-comparison-of-interventional-treatment-by-anterograde-or-retrograde-catheterization-for-acute-lower-extremity-deep-venous-thrombosis
#8
G P Chen, J P Gu, X He, W S Lou, Y Wang, L Chen, H B Su, W Y Shi, T Wang
Objective: To compare the clinical efficacy differences between anterograde and retrograde catheterization interventional treatment for acute low extremity deep venous thrombosis(DVT). Methods: The clinical data of 217 patients with acute low extremity DVT between January 2009 and December 2014 were analyzed retrospectively. Group A: 67 patients underwent treated with anterograde catheterization interventional treatment. Group B: 150 patients underwent treated with retrograde catheterization interventional treatment...
February 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28214484/hybrid-operative-thrombectomy-is-noninferior-to-percutaneous-techniques-for-the-treatment-of-acute-iliofemoral-deep-venous-thrombosis
#9
Limael E Rodríguez, Aihab Aboukheir-Aboukheir, Ricardo Figueroa-Vicente, Hiram Soler-Bernardini, Guillermo Bolanos-Avila, Luis J Torruella-Bartolomei, Anthony J Comerota, Jorge L Martinez-Trabal
OBJECTIVE: Hybrid operative thrombectomy (HOT) is a novel technique for the treatment of acute iliofemoral deep venous thrombosis (IFDVT) and is an alternative to percutaneous techniques (PTs) that use thrombolytics. In this study, we compare perioperative and intermediate outcomes of HOT vs PT as interventions for early thrombus removal. METHODS: From July 2008 to May 2015, there were 71 consecutive patients who were treated with either PT (n = 31) or HOT (n = 40) for acute or subacute single-limb IFDVT...
March 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28176476/recurrent-atypical-haemolytic-uraemic-syndrome-post-kidney-transplant-due-to-a-cd46-mutation-in-the-setting-of-smarcal1-mediated-inherited-kidney-disease
#10
REVIEW
Samuel Chan, Andrew J Mallett, Chirag Patel, Ross S Francis, David W Johnson, David W Mudge, Nicole M Isbel
Disorders in the regulation of the alternate complement pathway often result in complement-mediated damage to the microvascular endothelium and can be associated with both glomerulonephritis and atypical haemolytic uraemic syndrome. Inherited defects in complement regulatory genes or autoantibodies against complement regulatory proteins are predictive of the severity of the disease and the risk of recurrence post kidney transplantation. Heterozygous mutations in CD46, which codes for a transmembrane cofactor glycoprotein membrane cofactor protein, usually have a lower incidence of end-stage kidney disease and decreased risk of recurrent disease post transplant, as wild-type membrane cofactor protein is present in the transplanted kidney...
February 2017: Nephrology
https://www.readbyqxmd.com/read/28176472/suspected-atypical-haemolytic-uraemic-syndrome-in-two-post-partum-patients-with-foetal-death-in-utero-responding-to-eculizumab
#11
REVIEW
Justin Chua, Kathy Paizis, Simon Z He, Peter Mount
BACKGROUND: Atypical haemolytic uraemic syndrome (aHUS) is a rare condition with the triad of microangiopathic haemolytic anaemia, thrombocytopenia and acute kidney injury. Other conditions that present in a similar manner peri-partum include thrombotic thrombocytopaenic purpura, and pregnancy associated conditions including HELLP syndrome (haemolysis, elevated liver enzymes and low platelets), severe pre-eclampsia and less commonly acute fatty liver of pregnancy. CASE REPORTS: We describe two cases of suspected aHUS, who presented post-partum with foetal death-in-utero at 33 and 37 weeks respectively...
February 2017: Nephrology
https://www.readbyqxmd.com/read/28123982/incidence-and-interventions-for-post-thrombotic-syndrome
#12
REVIEW
Jeffrey J Farrell, Christopher Sutter, Sidhartha Tavri, Indravadan Patel
Post-thrombotic syndrome (PTS) is a venous stress disorder that develops from long-term effects from a previous deep venous thrombosis (DVT). The morbidity associated with PTS may be significant and patients can present with edema, chronic pain, swelling, skin changes, and heaviness of the affected limb. PTS can eventually lead to a decreased quality of life and to a marked burden for the healthcare system. This article elaborates on clinical aspects of PTS including the pathophysiology, diagnostic work-up and management of the disease with a particular focus on endovascular options...
December 2016: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28123981/catheter-directed-interventions-for-inferior-vena-cava-thrombosis
#13
REVIEW
Yosef Golowa, Michael Warhit, Felipe Matsunaga, Jacob Cynamon
Inferior vena cava (IVC) thrombosis, although similar in many aspects to deep venous thrombosis (DVT), has distinct clinical implications, treatments and roles for endovascular management. Etiologies of IVC thrombosis vary from congenital malformations of the IVC to acquired, where indwelling IVC filters have been implicated as a leading cause. With an increasing incidence of IVC thrombosis throughout the United States, clinicians need to be educated on the clinical signs and diagnostic tools available to aid in the diagnosis as well as available treatment options...
December 2016: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28123980/catheter-directed-interventions-for-acute-deep-vein-thrombosis
#14
REVIEW
Maureen P Kohi, Ryan Kohlbrenner, Kanti P Kolli, Evan Lehrman, Andrew G Taylor, Nicholas Fidelman
Venous thromboembolism (VTE) is an extremely common form of vascular disease and impacts a great number of patients worldwide. Acute deep vein thrombosis (DVT) is a subset of VTE and is traditionally been treated with anticoagulation. There is good quality data which suggests the use of catheter directed interventions for the treatment of acute DVT with the aim of reducing post-thrombotic syndrome (PTS). The present review will discuss the various therapies available for acute DVT, focusing on catheter directed interventions, ranging from traditional anticoagulation to the most novel forms of aspiration thrombectomy...
December 2016: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28123973/imaging-of-venous-compression-syndromes
#15
REVIEW
Evan J Zucker, Suvranu Ganguli, Brian B Ghoshhajra, Rajiv Gupta, Anand M Prabhakar
Venous compression syndromes are a unique group of disorders characterized by anatomical extrinsic venous compression, typically in young and otherwise healthy individuals. While uncommon, they may cause serious complications including pain, swelling, deep venous thrombosis (DVT), pulmonary embolism, and post-thrombotic syndrome. The major disease entities are May-Thurner syndrome (MTS), variant iliac vein compression syndrome (IVCS), venous thoracic outlet syndrome (VTOS)/Paget-Schroetter syndrome, nutcracker syndrome (NCS), and popliteal venous compression (PVC)...
December 2016: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28123969/real-time-magnetic-resonance-imaging-of-deep-venous-flow-during-muscular-exercise-preliminary-experience
#16
Arun Antony Joseph, Klaus-Dietmar Merboldt, Dirk Voit, Johannes Dahm, Jens Frahm
BACKGROUND: The accurate assessment of peripheral venous flow is important for the early diagnosis and treatment of disorders such as deep-vein thrombosis (DVT) which is a major cause of post-thrombotic syndrome or even death due to pulmonary embolism. The aim of this work is to quantitatively determine blood flow in deep veins during rest and muscular exercise using a novel real-time magnetic resonance imaging (MRI) method for velocity-encoded phase-contrast (PC) MRI at high spatiotemporal resolution...
December 2016: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28123163/overview-of-current-evidence-on-the-impact-of-the-initial-high-dose-of-the-direct-factor-xa-inhibitor-rivaroxaban-on-thrombus-resolution-in-the-treatment-of-venous-thromboembolism
#17
Rupert Bauersachs, Norimichi Koitabashi
Incomplete thrombus resolution in patients with venous thromboembolism (VTE) may increase the risk of recurrent thromboembolic events and other complications, such as post-thrombotic syndrome. Various options exist for thrombus resolution, including systemic thrombolytic agents, catheter-directed thrombolysis, and traditional anticoagulants such as heparins or vitamin K antagonists (VKAs). Data are accumulating on the use of non-VKA oral anticoagulants, such as rivaroxaban, and these may provide greater thrombus resolution compared with VKAs...
February 7, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28121229/post-thrombotic-syndrome-following-deep-vein-thrombosis-in-paediatric-patients
#18
Klara Vosicka, Mahim I Qureshi, Susan E Shapiro, Chung S Lim, Alun H Davies
Background Although well characterised in adults, less is known about post-thrombotic syndrome in children. In this review, current knowledge regarding paediatric post-thrombotic syndrome is summarised, with particular emphasis on pathophysiology, aetiology, diagnosis and management. Methods A Medline literature review was performed using search terms 'post thrombotic syndrome', 'post phlebitic syndrome', paediatric and children. Relevant articles were identified and included for summation analysis. Results The incident of paediatric venous thromboembolism is rising...
January 1, 2017: Phlebology
https://www.readbyqxmd.com/read/28115812/ivus-guided-implantation-of-bioresorbable-vascular-scaffolds-for-very-late-paclitaxel-stent-thrombosis
#19
Zhe-Zhong Lin, Wei-Ting Chang, Chun-Yen Chiang, Zhih-Cherng Chen, Po-Ming Ku
Bioresorbable vascular scaffold (BVS) implantation has been shown to be safe in patients with stable coronary disease, and effective against the thrombotic lesion and the in-stent restenosis (ISR) of the drug-eluting stent (DES). BVSs have the advantages of a snow racket concept, positive vessel remodeling, and better conformability compared with DES in acute coronary syndrome (ACS). We report on a young patient with ST-elevation myocardial infarction (STEMI) who presented to our emergency department arising from very late stent thrombosis (VLST) of a 2...
January 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/28105087/long-term-prognostic-analysis-of-early-interventional-therapy-for-lower-extremity-deep-venous-thrombosis
#20
Qiang Li, Zongxue Yu, Jinjun Wang, Xiao Chen, Lin Li
The aim of the present study was to observe the long-term prognostic value of early interventional therapy for lower extremity deep venous thrombosis (LDVT). In total, 85 patients diagnosed with LDVT for the first time were consecutively selected (identified course of disease was <3 months), and were divided into the control group with 43 cases and the observation group with 42 cases according to different therapeutic methods. The control group received anticoagulation therapy and thrombolysis, or integrated surgical thrombectomy, a conventional open operation, while the observation group received comprehensive treatment, combining endovascular catheter-directed thrombolysis and thrombectomy...
December 2016: Experimental and Therapeutic Medicine
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