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Stomach carcinoid

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https://www.readbyqxmd.com/read/27734708/-multiple-endocrine-neoplasia-i-wermers-syndrome-forms-of-clinical-manifestation-5-case-studies
#1
Karolína Drbalová, Kateřina Herdová, Petr Krejčí, Monika Nývltová, Svatopluk Solař, Lenka Vedralová, Pavel Záruba, David Netuka, Petr Bavor
Multiple Endocrine Neoplasia (MEN) is a condition in which several endocrine organs of an individual are affected by adenoma, hyperplasia and less often carcinoma, either simultaneously or at different stages of life. Two existing syndromes, MEN1 and MEN2 (2A, 2B), in literature is also mentioned MEN4, are associated also with other non-endocrine disorders. MEN1 (Wermer syndrome) affects the pituitary, parathyroid, and pancreatic area. 95 % of patients show very early manifestation of hyperparathyroidism, often before 40 years of age...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27442656/well-differentiated-neuroendocrine-tumor-of-the-stomach-a-rare-case-at-an-uncommon-site
#2
Burak Gumuscu, Kevin Norwood, George A Parker, C Lee Bridges, Carl B Rountree
INTRODUCTION: A 13-year-old African-American female presented to her primary care physician's office with fatigue, syncope, and hematemesis. After initial evaluation, the patient was referred to pediatric gastroenterology clinic for further evaluation. MAIN CONCERNS, IMPORTANT FINDINGS: An upper gastrointestinal endoscopy was performed to evaluate the source of her bleeding. Endoscopy revealed a 3-cm mass in the lesser curvature of the stomach, and a biopsy of the mass revealed a concern for carcinoid (neuroendocrine) features...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27149136/paraneoplastic-scleroderma-are-there-any-clues
#3
Hana Jedlickova, Veronika Durčanská, Vladimír Vašků
Dear Editor, Scleroderma associated with neoplasia is rare, with only a small number of cases reported. We describe 4 patients with paraneoplastic scleroderma who were treated at the I. Department of Dermatovenereology, St. Anna Hospital, during the period between 2004 and 2014. The patients were diagnosed with cholangiogenic carcinoma, endometrial carcinoma, prostatic adenocarcinoma, and adenoma of the suprarenal gland. In the case of concurrent scleroderma and tumor, four situations may occur: they can develop independently of each other; scleroderma may be induced by the tumor; the tumor can develop in the scleroderma; or the tumor can be induced by immunosuppressive therapy...
April 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/27134715/histopathologic-prolife-of-primary-gastrointestinal-malignancies-in-uyo-city-niger-delta-region-of-nigeria
#4
Emmanuel K Abudu, Oluyinka S Akinbami
Incidence of gastrointestinal malignancy is gradually increasing. The aim of the study is to investigate age, sex and relative frequencies of various gastrointestinal malignancies diagnosed between January 2007 and December 2014 in the University of Uyo Teaching Hospital, and in a Private Specialist Laboratory, Uyo, Akwa Ibom State, Nigeria. All histological-diagnosed cases of gastrointestinal malignancies seen during the study period were recruited noting their bio-data and histopathological characteristics...
March 21, 2016: Rare Tumors
https://www.readbyqxmd.com/read/27021085/chromogranin-as-a-biochemical-marker-of-neuroendocrine-tumors
#5
N V Lyubimova, T K Churikova, N E Kushlinskii
Comparative study of plasma chromogranin A levels was carried out in 227 patients with neuroendocrine tumors of various locations and 66 normal subjects, men and women, by standard ELISA. In patients with tumors of all locations (pancreas, stomach, small and large intestine, and lungs), the glycoprotein levels were significantly (p<0.000001) higher than in controls. The patients demonstrated high variability of chromogranin A levels; the maximum concentrations were detected in patients with neuroendocrine tumors of the stomach and lung...
March 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27017730/gastric-carcinoid-type-1-in-a-patient-with-autoimmune-polyglandular-syndrome-additional-endocrinological-evaluation-required
#6
Ana Marija Vrkljan, David Grasić, Ivan Kruljac, Marko Nikolić, Jaksa Filipović-Cugura, Monika Ulamec, Ksenija Kovacić, Nenad Babić, Neven Ljubicić
Autoimmune polyglandular syndrome by definition consists of two or more endocrinological insufficiencies or two organ specific autoimmune diseases. There are no stringent criteria for endocrinological evaluation of patients with one endocrine insufficiency. However, detailed endocrinological evaluation should be undertaken in patients with two autoimmune diseases. Additionally, follow up thereafter should be a must in these patients in order to avoid the possibility of not diagnosing subsequent autoimmune diseases that can occur...
December 2015: Acta Clinica Croatica
https://www.readbyqxmd.com/read/26910279/assessment-of-cholecystokinin-2-receptor-cck2r-in-neoplastic-tissue
#7
Jyoti Roy, Karson S Putt, Domenico Coppola, Marino E Leon, Farah K Khalil, Barbara A Centeno, Noel Clark, Valerie E Stark, David L Morse, Philip S Low
The expression of cholecystokinin 2 receptor (CCK2R, CCKBR or gastrin receptor) has been reported on a diverse range of cancers such as colorectal, liver, lung, pancreatic, ovarian, stomach, thyroid and numerous neuroendocrine/carcinoid tumors. Some cancers of the colorectum, lung, pancreas and thyroid have been shown to overexpress CCK2R in relation to normal matched tissues of the same organ. This reported overexpression has led to the development of a number of CCK2R-ligand targeted imaging and therapeutic agents...
March 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/26898512/current-guidelines-in-the-management-of-upper-gastrointestinal-subepithelial-tumors
#8
REVIEW
Jin Woong Cho
Subepithelial tumors are frequently found in asymptomatic patients in Japan and Korea where cancer screening tests routinely include endoscopy. Most lesions are asymptomatic and clinically insignificant. However, carcinoid tumors, lymphomas, glomus tumor and gastrointestinal stromal tumors (GISTs) are malignant or have the potential to become malignant. Inflammation due to parasitic infestation by Anisakis and poorly differentiated adenocarcinomas in the stomach rarely present as subepithelial lesions. In contrast to the frequency of gastric GIST in the gastrointestinal system, they are uncommon in the duodenum and very rare in the esophagus...
May 2016: Clinical Endoscopy
https://www.readbyqxmd.com/read/26860771/deletion-of-men1-and-somatostatin-induces-hypergastrinemia-and-gastric-carcinoids
#9
Sinju Sundaresan, Anthony J Kang, Michael M Hayes, Eun-Young K Choi, Juanita L Merchant
BACKGROUND: Gastric carcinoids are slow growing neuroendocrine tumours arising from enterochromaffin-like (ECL) cells in the corpus of stomach. Although most of these tumours arise in the setting of gastric atrophy and hypergastrinemia, it is not understood what genetic background predisposes development of these ECL derived tumours. Moreover, diffuse microcarcinoids in the mucosa can lead to a field effect and limit successful endoscopic removal. OBJECTIVE: To define the genetic background that creates a permissive environment for gastric carcinoids using transgenic mouse lines...
February 9, 2016: Gut
https://www.readbyqxmd.com/read/26805231/-a-case-of-gastric-carcinoid-associated-with-hypergastrinemia-treated-with-latg
#10
Toshiya Michiura, Satoru Miyazaki, Kazuo Yamabe, Shigeo Fujita, Hajime Hirose, Yasuaki Miyazaki, Satoshi Sugimoto, Makio Nagaoka, Takashi Ozaki
A 67-year-old man had a gastric polyp diagnosed on screening. Atrophic changes in the upper gastric mucosa were seen on upper gastrointestinal endoscopy. In addition, endoscopy revealed in the middle area of the stomach wall a 10 mm polyp that was diagnosed as a carcinoid tumor through biopsy. Blood serum gastrin was elevated at 2,800 pg/mL.We diagnosed a Rindi Type 1 gastric carcinoid. The patient was planned to be treated with surgical laparoscopy assisted distal gastrectomy (LADG); however, the procedure was changed to intraoperative laparoscopy assisted total gastrectomy (LATG)...
November 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/26710953/-analysis-of-clinical-endoscopic-and-pathological-characteristics-of-gastric-hyperplastic-polyps
#11
Lingmei Meng, Liya Zhou, Yuan Li, Hejun Zhang, Zhu Jin, Rongli Cui
OBJECTIVE: To investigate the clinical, endoscopic and pathologic characteristics of gastric hyperplastic polyps. METHODS: A total of 1 676 gastric hyperplastic polyps patients diagnosed by gastroscopy and pathology from January 2005 to October 2014 were enrolled and analyzed retrospectively. RESULTS: Among them, 1 030 patients (61.46%) were female, 1 014 patients (60.50%) aged ≥ 60 years old, 1 093 patients (65.21%) polyps distributed in the fundus and body of stomach...
July 28, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/26681999/urticaria-as-initial-finding-of-a-patient-with-carcinoid-tumor
#12
Ivan Cherrez Ojeda, Juan Carlos Calderon, Karin Plaza, Emanuel Vanegas, Annia Cherrez, José Cano
BACKGROUND: Typical carcinoid syndrome is characterized by flushing, abdominal pain and diarrhea and occurs in <10 % of carcinoid tumor patients. Very rarely, initial signs include skin manifestations. Our purpose is to highlight cutaneous manifestations in the diagnosis and assessment of a patient with atypical manifestation of type I gastric carcinoid tumor. CASE PRESENTATION: A 50-year-old woman presented with anemia, chronic urticaria and angioedema. Urticaria was triggered principally by seafood and appeared in the first hour after...
2015: World Allergy Organization Journal
https://www.readbyqxmd.com/read/26516377/clinical-features-of-gastroenteropancreatic-tumours
#13
REVIEW
Paweł Gut, Agata Czarnywojtek, Maciej Bączyk, Katarzyna Ziemnicka, Jakub Fischbach, Elżbieta Wrotkowska, Marek Ruchała
Gastroenteropancreatic (GEP) endocrine tumours (carcinoids and pancreatic islet cell tumours) are composed of multipotent neuroendocrine cells that exhibit a unique ability to produce, store, and secrete biologically active substances and cause distinct clinical syndromes. The classification of GEP tumours as functioning or non-functioning is based on the presence of symptoms that accompany these syndromes secondary to the secretion of hormones, neuropeptides and/or neurotransmitters (functioning tumours). Non-functioning tumours are considered to be neoplasms of neuroendocrine differentiation that are not associated with obvious symptoms attributed to the hypersecretion of metabolically active substances...
2015: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/25956067/asymptomatic-heterotopic-pancreas-in-meckel-s-diverticulum-a-case-report-and-review-of-the-literature
#14
REVIEW
Alfredas Kilius, Narimantas Evaldas Samalavicius, Donatas Danys, Gytis Zaldokas, Dmitrij Seinin
INTRODUCTION: Heterotopic pancreas is defined as pancreatic tissue without a real anatomical or vascular connection to the pancreas. It can be found in the stomach, duodenum, jejunum, ileum, Meckel's diverticulum, colon gall bladder, umbilicus, fallopian tube, mediastinum, spleen and liver. Complications of heterotopic pancreas are inflammation, bleeding, obstruction, malignant transformation, carcinoid syndrome, jejunojejunal intussusception and ileus, but it is usually asymptomatic and diagnosed only during examinations for other diseases...
2015: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/25731345/-a-case-of-resection-of-pancreatic-head-lymph-node-metastasis-of-rectal-carcinoid
#15
Hiroyoshi Takemoto, Yoshio Uemura, Taro Aoki, Naoto Tsujimura, Eiichiro Nakao, Toru Otsuru, Risa Watanabe, Takashi Matsumoto, Kiyonori Nishioka, Ko Takachi, Shohei Iijima, Kenji Kobayashi
An 80-year-old woman was treated with low anterior resection and D3 lymph node dissection for rectal carcinoid in August 2007. Pathological diagnosis was a tumor 23 × 22 mm in size with muscularis propria invasion, ly1, v0, n1 (No. 251[1/12]). Partial hepatectomy was performed for liver metastasis in March 2010 and September 2011. In June 2013, an isolated tumor of 17 mm in diameter was detected between the inferior vena cava and the stomach using abdominal ultrasonography. The tumor was diagnosed as pancreatic head lymph node metastasis using abdominal enhanced computed tomography (CT), magnetic resonance cholangiopancreatography (MRCP), and positron emission tomography (PET); fluorodeoxyglucose (FDG) uptake was noted at the site of the tumor, but not at other parts of the body...
November 2014: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/25513174/single-port-intra-gastric-full-thickness-resection-using-rotation-and-revolution-single-instrument-tie-rrsit
#16
Ho Goon Kim, Seong Yeob Ryu, Dong Yi Kim
BACKGROUND/AIMS: Recently, minimize incisions has led to a reduction in the number of ports, and has led to transumbilical single-port surgery. We evaluated the treatment result of single-port, intragastric, full thickness resections for gastric SMTs. In addition, we introduce a novel intracorporeal knot tying method. METHODOLOGY: From August 2010 to March 2011, five patients underwent single-port intragastric, full thickness gastric wedge resections. After performing a gastrostomy, a single port was inserted into the stomach...
September 2014: Hepato-gastroenterology
https://www.readbyqxmd.com/read/25437655/laparoscopic-antral-resection-with-billroth-i-reconstruction-for-a-gastric-glomus-tumor
#17
Hamzeh M Halawani, Mohammad Khalife, Bassem Safadi, Khaled Rida, Fouad Boulos, Farah Khalifeh
INTRODUCTION: Gastric glomus tumors are fairly uncommon and mostly benign, with an estimated incidence of 1% of all GI soft tissue tumors. The most common GI site of involvement is the stomach, and in particular the antrum. Some cases have been discovered incidentally, but most are symptomatic presenting with GI bleeding, perforation or abdominal pain. Glomus tumors are submucosal tumors and hence mistaken with the more frequent gastrointestinal stromal tumors. PRESENTATION OF CASE: A 33-year-old woman presented with intermittent dull upper abdominal pain for two days...
2014: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/25436389/single-port-intra-gastric-full-thickness-resection-using-rotation-and-revolution-single-instrument-tie-rrsit
#18
Ho Goon Kim, Seong Yeob Ryu, Dong Yi Kim
BACKGROUND/AIMS: Recently, minimize incisions has led to a reduction in the number of ports, and has led to transumbilical single-port surgery. We evaluated the treatment result of single-port, intragastric, full thickness resections for gastric SMTs. In addition, we introduce a novel intracorporeal knot tying method. METHODOLOGY: From August 2010 to March 2011, five patients underwent single-port intragastric, full thickness gastric wedge resections. After performing a gastrostomy, a single port was inserted into the stomach...
September 2014: Hepato-gastroenterology
https://www.readbyqxmd.com/read/25385300/a-case-of-late-lymph-node-metastasis-after-three-endoscopic-mucosal-resections-of-intramucosal-gastric-cancers
#19
Eisuke Booka, Tsunehiro Takahashi, Kazunori Tokizawa, Yusuke Uchi, Akihiko Okamura, Kazumasa Fukuda, Rieko Nakamura, Norihito Wada, Hirofumi Kawakubo, Yoshiro Saikawa, Tai Omori, Hiroya Takeuchi, Aya Sasaki, Shuji Mikami, Koichiro Kumai, Kaori Kameyama, Yuko Kitagawa
We describe a patient with solitary lymph node (LN) metastasis after three endoscopic mucosal resections (EMRs) in which a gastrointestinal stromal tumor was difficult to differentiate from the carcinoid and lymphoma tumors. A 77-year-old man underwent three EMRs at 62, 72, and 75 years of age, and all resections were determined to be curative. However, 2 years after the last EMR, screening abdominal ultrasonography detected a 20-mm solitary tumor at the lesser curvature of the upper stomach. Laparoscopic tumor resection confirmed the pathological diagnosis...
2014: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25132927/neuroendocrine-tumors-of-the-gastrointestinal-tract-case-reports-and-literature-review
#20
William J Salyers, Kenneth J Vega, Juan Carlos Munoz, Bruce W Trotman, Silvio S Tanev
Neuroendocrine tumors (NET) previously called carcinoid tumors are neoplasms of enterochromaffin/neuroendocrine cell origin which display neurosecretory capacity that may result in the carcinoid syndrome. The annual incidence of patients with NET is 8.4 per 100000; yet many NET remain asymptomatic and clinically undetected. A majority of NET follows a benign course; however, some will display malignant characteristics. NET most commonly occur in the gastrointestinal tract (67%) and bronchopulmonary system (25%)...
August 15, 2014: World Journal of Gastrointestinal Oncology
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