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Gastric carcinoid

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https://www.readbyqxmd.com/read/28914716/diagnostic-utility-of-satb2-in-metastatic-krukenberg-tumors-of-the-ovary-an-immunohistochemical-study-of-70-cases-with-comparison-to-cdx2-ck7-ck20-chromogranin-and-synaptophysin
#1
Chen Yang, Li Sun, Lingxin Zhang, Lixin Zhou, Ming Zhao, Yan Peng, Dongfeng Niu, Zhongwu Li, Xiaozheng Huang, Qiang Kang, Lin Jia, Jinping Lai, Dengfeng Cao
SATB2 is a sensitive marker for colorectal adenocarcinomas. No study has investigated its diagnostic utility in metastatic Krukenberg tumors (MKTs) of the ovary. Here we performed immunohistochemical staining SATB2 in 70 MKTs of various origins (stomach 27, colorectum 13, appendix 20 including 19 metastatic adenocarcinomas ex goblet cell carcinoids [AdexGCC] and 1 conventional poorly differentiated carcinoma with signet ring cells, breast 5, bladder 3, lung 2) to assess its diagnostic utility. We also compared SATB2 with CDX2, CK7, CK20, chromogranin, and synaptophysin in MKTs of gastric origin (MKTs-stomach), those of colorectal origin (MKTs-colorectum) and those due to appendiceal AdexGCCs (MKT-AdexGCCs) for their sensitivity and specificity to distinguish these tumors...
September 13, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28889157/epidemiologic-characteristics-of-gastric-malignancies-among-jordan-university-hospital-patients
#2
Heyam A Awad, Manar H Hajeer, Mohand W Abulihya, Mohammad A Al-Chalabi, Ali A Al Khader
To discover the epidemiologic distribution of gastric malignancies among Jordan University Hospital patients and to compare this distribution with the neighboring Arab countries. Methods: Retrospective study covering the period between  January 2006, and May 2016, in Jordan University Hospital, Amman, Jordan. All cases were retrieved from the computer system and analyzed using IBM SPSS version 23 software.  Results: One hundred and sixty-five cases were analyzed. Male-to-female ratio was 1.2:1. The mean age was 58...
September 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28876642/outcome-of-liver-resection-for-carcinoid-neuroendocrine-metastases
#3
M D Polkinghorne, J E J Krige, E Jonas, U K Kotze, M M Bernon
BACKGROUND: Gastrointestinal carcinoid tumours, despite their low malignant potential, frequently metastasize to the liver. While liver resection improves survival and provides symptomatic relief, multifocal bilobar disease complicates surgical management. METHOD: All patients with carcinoid liver secondaries managed by resection from 1990-2015 were identified from a prospective departmental database. Demographic data, operative management, morbidity using the Accordion classification and mortality were analysed...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28868481/the-role-of-endoscopic-ultrasound-in-the-diagnostic-assessment-of-subepithelial-lesions-of-the-upper-gastrointestinal-tract
#4
Francisca Dias de Castro, Joana Magalhães, Sara Monteiro, Sílvia Leite, José Cotter
INTRODUCTION: The identification of subepithelial lesions is a relatively frequent finding at endoscopy however their natural history is not well known. Our aim was to analyze the role of endoscopic ultrasound (EUS) in the diagnostic approach of subepithelial lesions of the upper gastrointestinal tract. METHODS: Retrospective study which included 324 patients undergoing upper radial EUS for evaluation of subepithelial lesions from 2008 to 2014. The EUS features, presumptive diagnosis and management decision were analyzed...
November 2016: GE Port J Gastroenterol
https://www.readbyqxmd.com/read/28808875/ssat-state-of-the-art-conference-current-surgical-management-of-gastric-tumors
#5
Jeffrey A Norton, Teresa Kim, Joseph Kim, Martin D McCarter, Kaitlyn J Kelly, Joyce Wong, Jason K Sicklick
INTRODUCTION: The current era of gastric surgery is marked by low morbidity and mortality rates, innovative strategies to approach resections with a minimally invasive fashion or hyperthermic intraperitoneal chemotherapy (HIPEC), as well as improved understanding of the biology of sporadic and hereditary stromal, neuroendocrine, and epithelial malignancies. METHODS: In 2017, the Society for Surgery of the Alimentary Tract convened a State-of-the-Art Conference on Current Surgical Management of Gastric Tumors with both international experts and emerging leaders in the field of gastric surgery...
August 14, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28808566/laparoscopic-double-tract-reconstruction-after-total-gastrectomy-for-postoperative-duodenal-surveillance-case-series
#6
Ryota Otsuka, Hideki Hayashi, Naoyuki Hanari, Hisashi Gunji, Koichi Hayano, Masayuki Kano, Hisahiro Matsubara
INTRODUCTION: When gastric cancer or carcinoid patients have coexisting diseases such as duodenal adenoma, FAP, or Crohn's disease, periodic observation of the duodenum is necessary. METHODS: Between August 2013 and April 2015, we performed four consecutive laparoscopic total gastrectomies with double tract reconstruction for duodenal surveillance. Three of the patients were diagnosed with gastric cancer, while the remaining patient was diagnosed with gastric carcinoid...
September 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28763328/surgical-intervention-in-gastric-carcinoid-is-associated-with-improved-survival-in-local-and-regional-disease
#7
Ann F Callahan, Michael White, Philip Ituarte, Singh Gagandeep, Yanghee Woo, Yuman Fong, Laleh Melstrom
INTRODUCTION: Gastric carcinoid is a rare entity with complex management options. This study aims to determine if surgical intervention in patients with local, regional, and metastatic gastric carcinoid is associated with prolonged survival. MATERIALS AND METHODS: The California Cancer Registry merged with the California Office of Statewide Health Planning and Development was queried for patients with a diagnosis of gastric carcinoid (2000 to 2011). Clinicopathologic characteristics, management, and outcomes were evaluated...
July 31, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28658787/gastric-glomus-tumour-misdiagnosed-as-gastric-carcinoid-an-unfamiliar-entity-with-aids-to-diagnosis-and-review-of-literature
#8
Tanush Vig, Mandeep Singh Bindra, Ramani Manoj Kumar, Suceena Alexander
Glomus tumour (GT) is a rare mesenchymal tumour of the stomach with Gastrointestinal Stromal Tumour (GIST), leiomyoma and schwannoma being far more common and comprising more than 90% of all gastric mesenchymal tumours. As glomus bodies are located in the peripheral parts of the human body, these tumours are peripherally located, classically the subungual region, hands, feet and trunk. While being evaluated for renal problems, a middle aged lady was incidentally found to have a gastric tumour. This was submucosal in location and was excised by a wedge resection and reported elsewhere as carcinoid tumour...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28649475/solid-pseudopapillary-tumor-of-the-pancreas-an-unusual-cause-of-abdominal-pain
#9
Talal El Imad, Fady G Haddad, Mayurathan Kesavan, Liliane Deeb, Sherif Andrawes
Solid-pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor that accounts for less than one percent of pancreatic tumors. The diagnosis could be challenging as SPN tend to manifest with nonspecific abdominal symptoms, variable radiological features, and inconsistent morphology. The cellular origin of SPN is unclear and might involve ductal, acinar and endocrine stem cells.  We report a rare case of a 27-year-old female who presented with intermittent abdominal pain for two years, associated with a decrease in appetite...
May 16, 2017: Curēus
https://www.readbyqxmd.com/read/28625066/a-rectal-neuroendocrine-neoplasm
#10
Modesto J Varas Lorenzo, Fernando Muñoz Agel
The incidence of gastric and rectal carcinoids is increasing. This is probably due to endoscopic screening. The prognosis is primarily dependent upon tumor size, aggressiveness (pathology, Ki-67), metastatic disease and stage. However, neuroendocrine carcinoma usually behaves as an adenocarcinoma.
June 19, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28608155/pathophysiology-of-gastric-nets-role-of-gastrin-and-menin
#11
REVIEW
Sinju Sundaresan, Anthony J Kang, Juanita L Merchant
PURPOSE OF REVIEW: Neuroendocrine tumors (NETs) were initially identified as a separate entity in the early 1900s as a unique malignancy that secretes bioactive amines. GI-NETs are the most frequent type and represent a unique subset of NETs, because at least 75% of these tumors represent gastrin stimulation of the enterochromaffin-like cell located in the body of the stomach. The purpose of this review is to understand the specific role of gastrin in the generation of Gastric NETs (G-NETs)...
July 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28465633/unusual-gastric-tumors-and-tumor-like-lesions-radiological-with-pathological-correlation-and-literature-review
#12
REVIEW
Yuan-Mao Lin, Nai-Chi Chiu, Anna Fen-Yao Li, Chien-An Liu, Yi-Hong Chou, Yi-You Chiou
Although gastric tumors have overlapping radiologic appearances, some unusual tumors may present specific imaging features. Using multidetector computed tomography (MDCT), with water as a negative oral contrast agent and intravenous contrast medium, can provide critical information for the diagnosis of gastric diseases. In addition, MDCT can evaluate the involvement of the gastric wall and extragastric extent of the disease, as compared with gastroenteroscopy and double-contrast upper gastrointestinal study...
April 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28405320/distinct-metaplastic-and-inflammatory-phenotypes-in-autoimmune-and-adenocarcinoma-associated-chronic-atrophic-gastritis
#13
Sangho Jeong, Eunyoung Choi, Christine P Petersen, Joseph T Roland, Alessandro Federico, Rossana Ippolito, Francesco P D'Armiento, Gerardo Nardone, Osamu Nagano, Hideyuki Saya, Marco Romano, James R Goldenring
BACKGROUND: Autoimmune gastritis (AIG) and adenocarcinoma-associated chronic atrophic gastritis (CAG) are both associated with oxyntic atrophy, but AIG patients demonstrate an increased risk of carcinoid tumors rather than the elevated risk of adenocarcinoma observed with CAG. We therefore sought to compare the characteristics of the metaplastic mucosa in AIG and CAG patients. METHODS: We examined markers for metaplasia (spasmolytic polypeptide expressing metaplasia (SPEM) and intestinal metaplasia) as well as proliferation (Ki67) and immune cell populations (neutrophils, macrophages, and eosinophils) in gastric sections from 16 female patients with autoimmune thyroiditis and AIG and 17 patients with CAG associated with gastric adenocarcinoma...
February 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28369403/serum-gastrin-and-cholecystokinin-are-associated-with-subsequent-development-of-gastric-cancer-in-a-prospective-cohort-of-finnish-smokers
#14
Gwen Murphy, Christian C Abnet, Hyoyoung Choo-Wosoba, Emily Vogtmann, Stephanie J Weinstein, Philip R Taylor, Satu Männistö, Demetrius Albanes, Sanford M Dawsey, Jens F Rehfeld, Neal D Freedman
Background: Gastrin, which induces gastric acid secretion, and a structurally similar hormone, cholecystokinin (CCK)-a potent acid inhibitor, may each play a role in gastric cancer. However, few studies have investigated this hypothesis in humans. We therefore investigated whether serum gastrin or CCK concentrations at baseline were associated with the incidence of gastric non-cardia adenocarcinomas (GNCA), oesophagogastric junctional adenocarcinomas (EGJA) or gastric carcinoid tumours over 24 years of follow-up in a study nested within the all-male Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study of Finnish smokers...
March 27, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28300688/duodenal-gastrinoma-discovered-on-evaluation-for-incidental-gastric-carcinoid
#15
Preeth Jayaram, Alex Shindel, James Buxbaum
No abstract text is available yet for this article.
March 11, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28295914/development-of-a-gastric-carcinoid-tumor-following-allogeneic-hematopoietic-stem-cell-transplantation-for-early-t-cell-precursor-acute-lymphoblastic-leukemia
#16
Tsung-Yen Chang, Jin-Yao Lai, Chao-Jan Wang, Shih-Yen Chen, Tang-Her Jaing, Chuen Hsueh, Lee-Yung Shih, Shih-Hsiang Chen
Gastric carcinoid tumor is rarely diagnosed in children. We report a case of gastric carcinoid tumor that occurred after allogeneic HSCT. A 13-year-old girl with ETP acute lymphoblastic leukemia underwent allogeneic HSCT from a 7/8 HLA-matched unrelated donor. She presented with rashes, abdominal pain, and diarrhea, which were suggestive of GVHD, 7 months after HSCT. Immunosuppressive agents failed to resolve these symptoms well. After a series of evaluations, carcinoid syndrome caused by a gastric carcinoid tumor was diagnosed...
June 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28211282/signet-ring-cell-carcinoma-of-the-jejunum-an-uncommon-finding-within-the-reach-of-capsule-endoscopy
#17
José Francisco Juanmartiñena, Marta Montes, Ignacio Fernández-Urién
An 80 year-old female presented with ductal breast carcinoma (stage II) three years ago, complained of asthenia and iron-deficiency anemia. No diagnosis was obtained after conventional endoscopy and iron supplements were indicated. Ten months later visible digestive hemorrhage was presented. Upper and lower endoscopy was repeated but non-diagnosis was obtained. Thus, video capsule endoscopy was indicated identifying a stenotic lesion arising in the mucosa of distal jejunum. Histopathological examination revealed a poorly mucinous differentiated signet-ring cell adenocarcinoma with an intense peri-tumoral lymphoid (Crohn´s-like lymphoid reaction) and lympho-vascular infiltration with no nodal metastases (pT3N0;7ª edition TNM classification)...
February 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28205418/pediatric-neuroendocrine-carcinoid-tumors-management-pathology-and-imaging-findings-in-a-pediatric-referral-center
#18
Andrew J Degnan, Shannon Tocchio, Waleed Kurtom, Sameh S Tadros
BACKGROUND: While neuroendocrine (carcinoid) tumors are increasingly recognized in the adult population, they are often not suspected in children. PROCEDURE: Retrospective review of all well-differentiated neuroendocrine (carcinoid) tumors was performed based on pathology reports from a quaternary pediatric medical center between January 2003 and June 2016. Clinical presentations, treatment approaches, imaging findings, and outcomes were reviewed and analyzed. RESULTS: A total of 45 cases of pathology-proven carcinoid tumor were reported with an average age of 14...
February 16, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28053814/a-concurrence-of-adenocarcinoma-with-micropapillary-features-and-composite-glandular-endocrine-cell-carcinoma-in-the-stomach
#19
Ji-Hoon Kim, Dae-Woon Eom, Cheon-Soo Park, Jae-Young Kwak, Eun-Hwa Park, Jin-Ho Kwak, Hyuk-Jae Jang, Kun-Moo Choi, Myung-Sik Han
We report a unique case of synchronous double primary gastric cancer consisting of adenocarcinoma components with micropapillary features and composite glandular-endocrine cell carcinoma components. The patient was a 53-year-old man presenting with a 6-month history of epigastric pain and diarrhea. A subtotal gastrectomy was performed. Histologically, one tumor was composed of micropapillary carcinoma components (50%) with tight clusters of micropapillary aggregates lying in the empty spaces, admixed with moderately differentiated adenocarcinoma components...
December 2016: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28034664/cost-of-detecting-gastric-neoplasia-by-surveillance-endoscopy-in-atrophic-gastritis-in-italy-a-low-risk-country
#20
Edith Lahner, Cesare Hassan, Gianluca Esposito, Marilia Carabotti, Angelo Zullo, Mario Dinis-Ribeiro, Bruno Annibale
BACKGROUND: Atrophic gastritis (AG) is at increased risk of gastric neoplasia, thus surveillance gastroscopy has been proposed. AIMS: To assess cost of detecting gastric neoplasias by surveillance endoscopy according to identified risk factors in Italy. METHODS: Post-hoc analysis of a cohort study including 200 AG-patients from Italy followed up for a mean of 7.5 (4-23.4) years was done. Considered risk factors were: age >50years, extensive atrophy, pernicious anaemia, OLGA-OLGIM scores 3-4 at diagnosis...
March 2017: Digestive and Liver Disease
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