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Stomach GIST

Yoshiaki Maeda, Toshiki Shinohara, Tomonari Katayama, Akihisa Nagatsu, Noriaki Futakawa, Tomonori Hamada
Gastrointestinal stromal tumors (GISTs) of the stomach presenting as an intra-abdominal abscess are extremely rare. We herein report a case that underwent successful laparoscopic resection of gastric GIST presenting with an intra-abdominal abscess. A 70-year-old man presented with a 3-day history of acute upper abdominal pain with a fever. Laboratory data showed an elevated white blood cell count and C-reactive protein level. A CT scan revealed a mass of mixed solid and fluid components, measuring 5.5 cm, in the adjacent lesser curvature of the stomach...
May 2016: Case Reports in Gastroenterology
Giuseppe Portale, Mariano De Vito, Alberto Morabito, Massimiliano Zuccaro, Valentino Fiscon
INTRODUCTION: Schwannomas are slow-growing tumors, rarely occurring in the GI tract. When found, their location is mostly in the stomach. Presentation in the small bowel is extremely rare, anecdotal. CASE REPORT: We present the case of a 47-year old male who underwent laparoscopic elective left hemicolectomy for recurrent diverticulitis. RESULTS: At surgery an exophytic mass originating from the first jejunal loop was identified and resected, under the suspicion of a GIST...
July 8, 2016: Annali Italiani di Chirurgia
Ke-Kang Sun, Song Xu, Jinzhen Chen, Gang Liu, Xiaojun Shen, Xiaoyang Wu
Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms that arise in the gastrointestinal tract, accounting for ~1% of gastric malignancies. The present study reports the case of a GIST of the stomach in a 75-year-old man who presented with abdominal distension and anorexia for 1 month. Gastroscopy was unremarkable. Ultrasound and computed tomography (CT) scans showed a giant intraabdominal cystic lesion of unknown origin. The lesion was initially believed to be a duplication cyst, a pancreatic pseudocyst or a liver cyst in the pre-operative diagnosis...
October 2016: Oncology Letters
Sudhir Kumar Mohanty, Kumarmani Jena, Tanmaya Mahapatra, Jyoti Ranjan Dash, Dibyasingh Meher, Ajax John, Manjushree Nayak, Shafqat Bano
INTRODUCTION: Gastrointestinal stromal tumor (GIST) is the commonest mesenchymal tumor of GI tract and 60-70% of it seen in the stomach, whereas Gastric schwannoma is a benign, slow growing and one of the rare neoplasms of stomach. Age distribution, clinical, radiological features and gross appearance of both tumors are similar. PRESENTATION OF CASE: We report a rare case of gastric schwannoma in a 20-year-old girl, who underwent subtotal gastrectomy with the suspicion of a GIST preoperatively but later confirmed to be gastric schwannoma postoperatively after immunohistochemical study...
September 22, 2016: International Journal of Surgery Case Reports
Srijan Mazumdar, Sridhar Sundaram, Prachi Patil, Shaesta Mehta, Mukta Ramadwar
Adenocarcinomas are the most common cancers affecting stomach. However gastrointestinal stromal tumors (GIST), lymphomas and neuroendocrine tumors (NETs) can also affect the stomach. But stomach is relatively rare site of involvement by metastasis. In this case report a rare metastasis of germ cell tumor (GCT) into stomach is described which clinically and endoscopically masquerade as primary gastric cancers. But detailed clinical examination and vigilant histopathological reporting proves the origin of tumor distant from stomach and thereby change the whole approach of management...
August 2016: Annals of Translational Medicine
Vyacheslav Bard, Nikolai Menasherov, Sara Morgenstern, Riad Haddad, Hanoch Kashtan
BACKGROUND: Surgical resection is considered to be the best treatment for gastrointestinal stromal tumor (GIST), the most common mesenchymal tumor of the gastrointestinal tract. Tumor size, mitotic rate, and anatomic locations are directly related to the potential malignancy, surgical approach, oncological treatment, and recurrence rate. MATERIALS AND METHODS: This was a retrospective study of 40 patients who underwent surgical resection of histologically or immunohistochemistry-proven GIST of the stomach at the Rabin and Kaplan Medical Center between 2004 and 2013...
October 2016: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
Bartosz Cybułka, Maciej Golański, Jacek Rapeła, Andrzej Wach
Gastrointestinal stromal tumor is a rare pathology. GISTs account for 0.3-1% of all tumors of the gastrointestinal tract. At the same time, this type of cancer is the most common, malignant, non-epithelial tumor of the gastrointestinal tube. Over 90% of GISTs are found in the stomach and small intestine. This cancer usually develops without characteristic clinical symptoms and is diagnosed incidentally. This clinical situation, in which the first symptom of a GIST-pattern tumor includes a fully-symptomatic, non-complicated umbilical hernia, is an unprecedented anomaly...
September 1, 2016: Polski Przeglad Chirurgiczny
Ryuta Ide, Takahisa Suzuki, Yuji Takakura, Akihiko Oshita, Satoshi Ikeda, Yasuhiro Matsugu, Hideki Nakahara, Takashi Urushihara, Toshiyuki Itamoto, Katsunori Shinozaki
A 76-year-old woman with tarry stool was referred to our hospital for further examination. Contrast-enhanced computed tomography(CT)revealed a heterogeneous 15 cm tumor located in the left upper abdominal cavity. The tumor had a rich vascularity and was associated with intra-abdominal bleeding. Gastroscopy showed a large submucosal tumor in the gastric body. A biopsy was performed, and the patient was diagnosed with a c-kit-positive gastrointestinal stromal tumor(GIST)of the stomach. Imatinib mesylate(400mg/day)was administered for 6 months...
September 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Xue Chen, Hailong Cao, Sinan Wang, Dan Wang, Mengque Xu, Meiyu Piao, Bangmao Wang
BACKGROUND: Dieulafoy lesion is a rare but serious cause of gastrointestinal hemorrhage. However, some cases can be occasionally found without bleeding during the endoscopic screening, and the management remains unclear. The aim of this article was to report the efficacy and safety of endoscopic submucosal dissection (ESD) for silent gastric Dieulafoy lesions, which presented as protrusion lesions mimicking gastrointestinal stromal tumors (GISTs). METHODS: Data from the patients with gastric protrusion lesions who underwent ESD from September 2008 to April 2016 in General Hospital, Tianjin Medical University, China were recorded...
September 2016: Medicine (Baltimore)
Minh Phan, Shari Jones, Justin Jenkins, Shubham Pant, Mohamad Khawandanah
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract and usually occur in the stomach and the small intestine. The pancreas is an extremely rare primary site for GISTs and there are 25 reported cases of pancreatic GIST with most being treated with surgical resection. We describe a 52-year-old African-American female who was diagnosed with limited stage small cell carcinoma in November 2009 and treated with concurrent cisplatin/etoposide chemotherapy and radiation...
2016: Case Reports in Oncological Medicine
Anant Ramaswamy, Deepak Jain, Arvind Sahu, Joydeep Ghosh, Priya Prasad, Kedar Deodhar, Nitin Shetty, Shripad Banavali, Shailesh Shrikhande, Vikas Ostwal
BACKGROUND: Multimodality treatment of gastrointestinal stromal tumor (GIST) with surgery and adjuvant imatinib mesylate (IM), along with an emerging role for neoadjuvant IM prior to evaluation for resectability has resulted in high survival rates. METHODS: We conducted a retrospective analysis of prospectively collected data of patients who underwent surgery for GIST, prior to or followed by IM therapy. A total of 112 patients underwent surgery between January 2009 and March 2015 at our centre...
August 2016: Journal of Gastrointestinal Oncology
S S Shi, X Wang, Q Y Xia, Z F Lu, S B Ye, W R Yang, R Li, H H Ma, Q Rao, X J Zhou
OBJECTIVE: To evaluate the utility of BRAF V600E allele-specific antibody in the diagnosis of gastrointestinal stromal tumors (GISTs). METHODS: BRAF V600E mutation-specific immunohistochemistry and BRAF sequencing were performed in 24 consecutive GISTs, including 14 cases of KIT or PDGFRA mutations and 10 cases of KIT/PDGFRA wild GISTs. RESULTS: GISTs of 11 men and 13 women with a mean age 54 years(range 29-75 years) were included with tumors arising from stomach (16 cases), small bowel (7 cases), and peritoneal cavity (1 case)...
August 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Toshirou Nishida, Osamu Goto, Chandrajit Premanand Raut, Naohisa Yahagi
Gastrointestinal stromal tumors (GISTs) are considered to be potentially malignant mesenchymal tumors of the gastrointestinal tract. Clinically relevant GISTs are rare; however, subclinical GISTs (mini-GISTs) (1-2 cm) and pathologic GISTs (micro-GISTs) (<1 cm) are frequently reported. Most mini-GISTs and almost all micro-GISTs of the stomach may exhibit benign clinical behavior, and only mini-GISTs with high-risk features may progress. For this review, a provisional algorithm was used to propose diagnostic and treatment strategies for patients with small GISTs...
October 15, 2016: Cancer
William Anderson, Brendan O'Sullivan, Frances Hughes, Claire Swift, Matthew Smith, Nayneeta Deshmukh, Philippe Taniere
AIMS: Recent literature suggests that clinically silent, microscopic GISTs are common incidental findings. The aim of this study was to examine the histological, immunohistochemical and molecular characteristics of these tumours, which we have defined as measuring ≤ 20 mm, in order to determine if the rate and spectrum of mutations is similar to that of clinically symptomatic GISTs METHODS AND RESULTS: 13 microscopic GISTs identified as incidental findings in patients undergoing management of concomitant disease were tested for KIT and PDGFRA mutations...
July 29, 2016: Histopathology
Ahmed Mahmoud Hamza, Emad Helmi Ayyash, Raed Alzafiri, Issam Francis, Sami Asfar
Gastrointestinal stromal tumours (GISTs) are solid tumours of the gastrointestinal tract, mostly found in the stomach and intestine. They rarely present as cystic lesions. A 74-year-old woman referred to the hepatopancreaticobiliary unit, with 3 months history of upper abdominal discomfort. Abdominal ultrasound scan showed a large cystic lesion in the epigastric region suggestive of a pancreatic pseudocyst. The CT-scan showed a 6.6×6×6.3 cm size cyst related to the pancreas and extending to the hepatogastric omentum...
2016: BMJ Case Reports
S G Shapoval'yants, R V Plakhov, A I Mikhalev, E D Fedorov, L M Mikhaleva, Z V Galkova, E E Ernazarov, E V Gorbachev
AIM: to evaluate objectively the effectiveness of currently used diagnostic and curative approaches to gastrointestinal stromal tumors (GIST). MATERIAL AND METHODS: Early and remote results of treatment of 49 patients with gastric GISTs were presented. Herewith in 20 (40.8%) patients the disease was complicated by gastrointestinal bleeding. 43 (87.7%) of 49 patients with gastric GIST were operated. Conventional surgery was performed in 24 (55.8%) cases, laparoscopic interventions - in 12 (28%) cases, endoscopic endoluminal - in 7 (16...
2016: Khirurgiia
Ryuichi Wada, Hiroki Arai, Shoko Kure, Wei-Xia Peng, Zenya Naito
Gastrointestinal stromal tumor (GIST) is a mesenchymal tumor of the gastrointestinal tract. Mutation of KIT and PDGFRA genes is implicated in the tumorigenesis. Approximately 10% of GISTs do not harbor mutation of these genes, and they are designated as "wild type" GIST. They are classified into succinate dehydrogenase (SDH)-deficient and non-SDH-deficient groups. SDH-deficient group includes Carney triad and Carney Stratakis syndrome. The patients are young women. Tumors occur in the antrum of the stomach, and tumor cells are epithelioid...
August 2016: Pathology International
Makoto Tomatsu, Jun Isogaki, Takahiro Watanabe, Kiyoshige Yajima, Takuya Okumura, Kimihiro Yamashita, Kenji Suzuki, Akihiro Kawabe, Akira Komiyama, Seiichi Hirota
Gastrointestinal stromal tumors (GISTs) are relatively common in neurofibromatosis type 1 (NF 1) patients. Approximately 90% of GISTs associated with NF 1 are located in the small intestine, while sporadic GISTs are most commonly located in the stomach. Here we report an extremely rare case of an NF 1 patient with multiple gastric GITs (90 or more) but without multiple small intestinal tumors. A 63-year-old female patient who had a history of NF 1 underwent surgery for a gastric neuroendocrine tumor and gastric submucosal tumor (SMT)...
2016: Case Reports in Surgery
Purushotham Kkrishnappa, Eu Jhin Loh, Ibtisam Binti Mohamad, Mahadevan Deva Tata, Meenakshi Akhilesh, Kandasami Palayan
PURPOSE: To study histomorphological and immunohistochemical patterns of gastro-intestinal stromal tumours (GISTs) in Malaysia. MATERIALS AND METHODS: A total of 29 GIST cases from Hospital Tuanku Ja'afar, Seremban ,were studied retrospectively over a period of 10 years from January 2002 to December 2011. Patient demographic data like age, sex and etnicity were collected. Tumour characteristics like site, maximum dimension and specimen type were analysed. Evaluation was according to established criteria into very low, low, intermediate and high-risk categories...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Emily F Mason, Jason L Hornick
Gastrointestinal stromal tumors (GISTs) that lack kinase mutations often show loss of function of the succinate dehydrogenase (SDH) complex, due to germline mutation or promoter hypermethylation. SDH-deficient GISTs are exclusive to the stomach and have a multinodular architecture. It has been suggested that conventional risk stratification criteria may not predict outcome for this group of tumors, although data are limited. Here, we report the clinical, histologic, and genetic findings from a large cohort of 76 SDH-deficient GISTs diagnosed from 2005 to 2015, identified on the basis of histologic features or family history (45 female/31 male; mean age at diagnosis 32 y; range 11 to 71 y; 10 patients 50 y of age or above)...
June 23, 2016: American Journal of Surgical Pathology
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