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https://www.readbyqxmd.com/read/28325196/management-of-gastrointestinal-stromal-tumors
#1
REVIEW
Emily Z Keung, Chandrajit P Raut
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasm of the gastrointestinal tract. The stomach is the most common site of origin. Management of GISTs changed after the introduction of molecularly targeted therapies. Although the only potentially curative treatment of resectable primary GISTs is surgery, recurrence is common. Patients with primary GISTs at intermediate or high risk of recurrence should receive imatinib postoperatively. Imatinib is also first-line therapy for advanced disease...
April 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/28324028/a-duodenal-sdh-deficient-gastrointestinal-stromal-tumor-in-a-patient-with-a-germline-sdhb-mutation
#2
M S Elston, S Sehgal, M Dray, E Phillips, J V Conaglen, R J Clifton-Bligh, A J Gill
Context: Gastrointestinal Stromal Tumors (GISTs) are mesenchymal tumors of the gastrointestinal tract arising from the interstitial cells of Cajal. Succinate dehydrogenase (SDH) deficient GISTs are a unique class of GIST defined by: loss of immunohistochemical expression of SDHB indicating dysfunction of the mitochondrial complex 2, lack of driver mutations in KIT and PDGFRA, and a distinctive morphology and natural history. To date, all reported SDH-deficient GISTs have arisen in the stomach...
March 15, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28321172/gastrointestinal-stromal-tumor-of-the-stomach-with-axillary-lymph-node-metastasis-a-case-report
#3
Naoki Kubo, Nobumichi Takeuchi
Gastrointestinal stromal tumors (GISTs) are the most common type of gastrointestinal mesenchymal tumors, although metastasis to the perigastric lymph nodes is relatively rare, compared with liver or peritoneal metastasis. In this report, we describe a case of stomach GIST with a solitary simultaneous metastasis in the left axillary lymph node. A 68-year-old man was diagnosed with a large upper-stomach GIST, and computed tomography and positron emission tomography revealed masses in the left axilla and right mediastinum...
March 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28314314/familial-gastrointestinal-stromal-tumor-with-germline-kit-mutations-accompanying-hereditary-breast-and-ovarian-cancer-syndrome
#4
Yuki Sekido, Seiji Ohigashi, Tsuyoshi Takahashi, Naoki Hayashi, Koyu Suzuki, Seiichi Hirota
BACKGROUND: Familial gastrointestinal stromal tumor (GIST) is a rare disease with germline mutations in the c-kit gene (KIT) or platelet-derived growth factor receptor alpha gene (PDGFRA). We had encountered multiple GISTs in the stomach and small intestine during a screening of ovarian cancer for a woman with hereditary breast and ovarian cancer syndrome (HBOC) with breast cancer susceptibility gene II (BRCA2) mutations. The aim of this study was to examine this case in detail. CASE REPORT: A 65-year-old woman diagnosed with HBOC harboring BRCA2 mutations was found to have multiple tumors in the stomach and small intestine by abdominal screening...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28275959/clinicopathological-and-prognostic-analysis-of-primary-gastrointestinal-stromal-tumor-presenting-with-gastrointestinal-bleeding-a-10-year-retrospective-study
#5
Zhijie Yin, Jinbo Gao, Weizhen Liu, Cheng Huang, Xiaoming Shuai, Guobin Wang, Kaixiong Tao, Peng Zhang
OBJECTIVES: The objectives of this paper were to investigate the clinicopathological characteristics and prognostic factors of GI-bleeding GIST patients and explore whether GI bleeding is a risk factor for GIST relapse. METHODS: Primary GIST patients with initial symptoms of GI bleeding or no GI bleeding were retrospectively studied. RESULTS: Up to 178 GI-bleeding GIST patients including 108 (60.7%) males and 70 (39.3%) females were evaluated for the clinicopathological characteristics...
March 8, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28243730/-gastrointestinal-stromal-tumors-of-the-stomach-and-precursor-lesions
#6
E Wardelmann, W Hartmann, M Trautmann, J Sperveslage, S Elges, E Hekeler, S Huss
Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors in the gastrointestinal tract although they are much less frequent than epithelial tumors. In more than 60% of cases they occur in the stomach. Especially small lesions measuring ≤1 cm in diameter, so-called microscopic GIST can occur multifocally, frequently in the proximal stomach wall and sometimes as an incidental finding in a gastrectomy specimen resected for gastric cancer. The multicentricity of GIST alone is not proof of a metastatic behavior or a syndromal or hereditary disease...
February 27, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28223675/-low-dose-and-interval-administration-of-imatinib-in-a-patient-with-liver-metastasis-of-the-gastrointestinal-stromal-tumor-of-the-stomach-a-case-report
#7
Nobuhiro Morinaga, Hideyuki Saito, Chika Komine, Asuka Matsumoto, Toshihide Katoh, Naritaka Tanaka, Kenji Nakazato, Takuro Nakamura, Yoshinori Shitara, Masatoshi Ishizaki
A 69-year-old woman underwent proximal gastrectomy with distal pancreatectomy and splenectomy for a gastrointestinal stromal tumor of the stomach.Adjuvant imatinib was administered for a year.Two years after resection of the tumor, liver metastasis in S8 was detected.Therefore, imatinib was re-administered at 300mg/day.After a year of re-administration, the patient suffered muscle cramps in the hands, and therefore imatinib was administered with intervals, such as 4 weeks administration and 4 weeks rest.Re -administration of imatinib was effective and her liver metastasis decreased in size...
February 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28218202/contrast-enhanced-endoscopic-ultrasound-and-endoscopic-ultrasound-elastography-in-gastrointestinal-stromal-tumors
#8
Andre Ignee, Christian Jenssen, Michael Hocke, Yi Dong, Wen-Ping Wang, Xin-Wu Cui, Matthias Woenckhaus, Sevastita Iordache, Adrian Saftoiu, Gudrun Schuessler, Christoph F Dietrich
BACKGROUND AND OBJECTIVES: Gastrointestinal stromal tumors (GISTs) represent the largest group of subepithelial tumors (SET) of the upper gastrointestinal (GI) tract. They may show malignant behavior, in contrast to other SET. Endoscopic ultrasound (EUS) is frequently used to characterize SET. With the introduction of contrast-enhanced ultrasound (CEUS) into EUS (CE-EUS), distinct enhancement patterns can be detected. In the presented study, the characteristic features of CE-EUS in GIST are analyzed and compared with those of other SET...
January 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28206938/a-review-of-sleeve-gastrectomy-specimen-histopathology
#9
Luke A Kinsinger, James C Garber, Oliver Whipple
With the increasing popularity of sleeve gastrectomy, many stomach specimens are being evaluated. Understanding the significance and treatment for unexpected pathology is important. This study examines the incidence of relevant histopathology of sleeve gastrectomy specimens. It evaluates previous data for each histopathology and provides recommendations for treatment. In this study, a retrospective review was performed for 241 patients who underwent sleeve gastrectomy from 2009 to 2014 at a single institution...
November 1, 2016: American Surgeon
https://www.readbyqxmd.com/read/28133332/-multidisciplinary-treatment-for-high-risk-gist-of-the-stomach
#10
Tomo Ishida, Shigeyuki Tamura, Atsushi Takeno, Kohei Murakami, Yohei Nose, Ryota Mori, Yasuo Oneda, Ryuichi Kuwahara, Takuya Sakamoto, Atsushi Naito, Yoshiteru Katsura, Yoshiaki Ohmura, Yoshinori Kagawa, Yutaka Takeda, Takeshi Kato
A 59-year-old man underwent total gastrectomy(with D2 dissection)and cholecystectomy for gastric cancer and a submucosal tumor of the stomach. The specimen was immunohistochemically positive for c-kit, the Ki-67 label index was 10%, and the mitotic count was 20/HPF. Finally, the patient was diagnosed with high-risk gastrointestinal stromal cancer with normal type gastric cancer. After discharge from hospital, we started administration of TS-1 as adjuvant therapy for the gastric cancer. As multiple recurrences of the GIST in the abdomen developed, the patient underwent 3 radical local resections...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133329/-a-case-of-a-laparoscopically-resected-gastrointestinal-stromal-tumor-of-the-stomach
#11
Tomoki Hariu, Yoshihito Nako, Shigeki Yamasaki, Takashi Kitade, Motomi Wakasa, Teruhisa Sonoyama
During treatment for sigmoid colon diverticulitis, a 72-year-old man underwent abdominal computed tomography, which revealed a gastric tumor that was approximately 40mm in diameter. He then underwent a detailed examination after the remission of diverticulitis. The gastric mucosa was found to be unremarkable on gastrointestinal endoscopy. On ultrasonic endoscopy, however, a hypoechoic mass of approximately 40mm in diameter was detected in the fourth layer of the gastric fornix and was believed to be a gastric submucosal tumor(SMT)...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133281/-a-case-of-gist-of-the-stomach-with-long-term-survival-after-multidisciplinary-treatment-including-four-surgical-resections-of-liver-metastases
#12
Masatoshi Kitakaze, Motohiro Hirao, Atsushi Miyamoto, Takuya Hamakawa, Kazuyoshi Yamamoto, Kazuhiro Nishikawa, Sakae Maeda, Mamoru Uemura, Masakazu Miyake, Naoki Hama, Michihiko Miyazaki, Masataka Ikeda, Shoji Nakamori, Hiroki Kiyokawa, Masayuki Mano, Mitsugu Sekimoto
The most frequent relapse site of gastrointestinal stromal tumors(GIST)is the liver. We encountered a patient with longterm survival treated with multidisciplinary treatment, including4 hepatectomies for liver metastases. The patient was a woman aged 69 years at the time of the first medical treatment. She underwent total gastrectomy and S6 segmental hepatec- tomy for a stomach GIST with a hepatic metastasis. The tumor diameter was 24 cm and the mitotic figure was 65/50 HPF. According to the guidelines, it was diagnosed as a high risk GIST based on strong positive immunostaining for CD34 and c-kit...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133274/-resection-of-a-huge-gastrointestinal-stromal-tumor-of-the-stomach-following-neoadjuvant-chemotherapy-with-imatinib
#13
Yoshihiro Sato, Hideaki Karasawa, Takeshi Aoki, Hirofumi Imoto, Naoki Tanaka, Kazuhiro Watanabe, Tomoya Abe, Munenori Nagao, Shinobu Ohnuma, Hiroaki Musha, Masanobu Takahashi, Fuyuhiko Motoi, Takeshi Naitoh, Chikashi Ishioka, Michiaki Unno
We report a case of a huge gastric gastrointestinal stromal tumor(GIST)that was safely resected followingpreoperative imatinib therapy. A 72-year-old woman was hospitalized with severe abdominal distension. Computed tomography revealed a 27×17 cm tumor in the left upper abdominal cavity. The patient was diagnosed with high risk GIST by EUS-FNA. We initiated preoperative adjuvant chemotherapy with imatinib to achieve a reduction of operative risks and functional preservation. After 6 months of chemotherapy, CT showed a reduction in the tumor size and the patient underwent partial gastrectomy and partial resection of the diaphragm...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133241/-the-characteristics-of-patients-with-gist-who-experienced-late-recurrence-after-resection
#14
Noriko Wada, Tsuyoshi Takahashi, Yukinori Kurokawa, Kiyokazu Nakajima, Yasuhiro Miyazaki, Tomoki Makino, Makoto Yamasaki, Shuji Takiguchi, Toru Masuzawa, Toshirou Nishida, Masaki Mori, Yuichiro Doki
The characteristics of patients with gastrointestinal stromal tumor(GIST)who need long-term surveillance after resection remain unclear. We investigated the characteristics of 14 patients with GIST who developed recurrence over 5 years after resection. The most common primary tumor site was the stomach, followed by the rectum and small intestine. We found that 58% of patients had low-risk tumors, and 29% of patients developed recurrence over 10 years after resection. The most common first recurrence site was local, followed by the liver and peritoneum...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28131864/comparison-of-fna-and-fine-needle-biopsy-for-eus-guided-sampling-of-suspected-gi-stromal-tumors
#15
Abdul Hamid El Chafic, David Loren, Ali Siddiqui, Rawad Mounzer, Natalie Cosgrove, Thomas Kowalski
BACKGROUND AND AIMS: Subepithelial lesions are found in about 1% of all EGD procedures, and GI stromal tumors are a type of subepithelial lesion commonly encountered. Although the majority of subepithelial lesions are benign, GI stromal tumors have malignant potential, making a definitive diagnosis important. Currently, the criterion standard for the diagnosis of GI stromal tumors is EUS-directed FNA (EUS-FNA). The definitive diagnosis of GI stromal tumors relies on immunohistochemical staining, which depends on enough tissue being submitted to the pathologist...
January 25, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28114506/surgical-management-of-adolescents-and-young-adults-with-gastrointestinal-stromal-tumors-a-us-population-based-analysis
#16
Katherine E Fero, Taylor M Coe, Paul T Fanta, Chih-Min Tang, James D Murphy, Jason K Sicklick
Importance: There is a dearth of population-based evidence regarding outcomes of the adolescent and young adult (AYA) population with gastrointestinal stromal tumors (GISTs). Objectives: To describe a large cohort of AYA patients with GISTs and investigate the effect of surgery on GIST-specific survival (GSS) and overall survival (OS). Design, Setting, and Participants: This retrospective cohort study of 392 AYA patients and 5373 older adult (OA) patients in the Surveillance, Epidemiology, and End Results (SEER) database with GISTs histologically diagnosed from January 1, 2001, through December 31, 2013, with follow-up through December 31, 2015, compared the baseline characteristics of AYA (13-39 years old) and OA (≥40 years old) patients and among AYA patients stratified by operative management...
January 18, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28079762/robotic-versus-laparoscopic-gastric-resection-for-primary-gastrointestinal-stromal-tumors-5-cm-a-size-matched-and-location-matched-comparison
#17
Nicola de'Angelis, Pietro Genova, Aurelien Amiot, Cecile Charpy, Mara Disabato, Ajay P Belgaumkar, Ali Chahrour, Francois Legou, Daniel Azoulay, Francesco Brunetti
This study compared robotic (RR) and laparoscopic resection (LR) for primary gastrointestinal stromal tumors (GISTs) of the stomach >5 cm. Twelve consecutive patients who underwent RR from 2012 to 2015 were matched for tumor size and location with 24 patients who underwent LR from 2000 to 2012. The median tumor size was 7.1 cm (range, 5.5 to 11.5). GISTs were resected by wedge resection (91.7%) or distal gastrectomy. The median RR operative time was longer than that of LR (162.5 vs. 130 min, respectively; P=0...
February 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28034324/p16-overexpression-in-braf-mutated-gastrointestinal-stromal-tumors
#18
Shan-Shan Shi, Xuan Wang, Qiu-Yuan Xia, Qiu Rao, Qin Shen, Sheng-Bin Ye, Rui Li, Qun-Li Shi, Zhen-Feng Lu, Heng-Hui Ma, Xiao-Jun Zhou
BACKGROUND: The aims of this study were to analyze the histopathology, immunophenotype, molecular features, and prognosis in cases of BRAF-mutated gastrointestinal stromal tumors (GISTs) and to examine the p16 expression in these tumors, and further discuss its effects on tumor formation and progression. METHODS: In all, 283 GIST cases (201 KIT mutants, 12 PDGFRA mutants and 70 wild-type) from the 2010 to 2014 surgical pathology files of the Department of Pathology at Nanjing Jinling Hospital were analyzed for mutations in BRAF exon 15...
December 30, 2016: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28006721/wide-local-excision-for-anal-gist-a-case-report-and-review-of-literature
#19
Mohamed Azzaza, Houssem Ammar, Nihed Abdessayed, Rahul Gupta, Mohamed Said Nakhli, Amine Chhaider, Nafis Abdennaceur, Ali Ben Ali
INTRODUCTION: Gastrointestinal stromal tumors (GIST) are tumors of mesenchymal origin commonly detected in stomach and small bowel. GIST arising primarily from the anal canal is extremely rare. Due to the malignant potential, these tumors are treated with radical surgery like abdominoperineal resection. But with the advent of imatinib therapy and a better understanding of the tumor biology, some cases have been successfully treated with wide local excision. PRESENTATION OF CASE: We describe a case of a 70-year-old lady presenting with a 2cm mass in the anal canal...
December 2, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27994335/perforated-gastrointestinal-stromal-tumor-of-the-meckel-s-diverticulum-a-case-report-and-review-of-literature
#20
Ishwar R Hosamani, Srinivas Kodaganur, S M Chaukimath
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the GI tract, they have a wide spectrum of clinical manifestations, and a small proportion of them present as an acute abdomen due to obstruction, perforation, or hemoperitoneum. We present a case of a perforated GIST of the Meckel's diverticulum and review the current literature on perforated GISTs. We ran a search on Pubmed and Google Scholar with the following terms "perforated GIST," "perforated Meckel's diverticulum," "GIST with peritonitis," and "GIST in Meckel's diverticulum...
October 2016: Indian Journal of Surgery
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