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Stomach GIST

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https://www.readbyqxmd.com/read/28223675/-low-dose-and-interval-administration-of-imatinib-in-a-patient-with-liver-metastasis-of-the-gastrointestinal-stromal-tumor-of-the-stomach-a-case-report
#1
Nobuhiro Morinaga, Hideyuki Saito, Chika Komine, Asuka Matsumoto, Toshihide Katoh, Naritaka Tanaka, Kenji Nakazato, Takuro Nakamura, Yoshinori Shitara, Masatoshi Ishizaki
A 69-year-old woman underwent proximal gastrectomy with distal pancreatectomy and splenectomy for a gastrointestinal stromal tumor of the stomach.Adjuvant imatinib was administered for a year.Two years after resection of the tumor, liver metastasis in S8 was detected.Therefore, imatinib was re-administered at 300mg/day.After a year of re-administration, the patient suffered muscle cramps in the hands, and therefore imatinib was administered with intervals, such as 4 weeks administration and 4 weeks rest.Re -administration of imatinib was effective and her liver metastasis decreased in size...
February 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28218202/contrast-enhanced-endoscopic-ultrasound-and-endoscopic-ultrasound-elastography-in-gastrointestinal-stromal-tumors
#2
Andre Ignee, Christian Jenssen, Michael Hocke, Yi Dong, Wen-Ping Wang, Xin-Wu Cui, Matthias Woenckhaus, Sevastita Iordache, Adrian Saftoiu, Gudrun Schuessler, Christoph F Dietrich
BACKGROUND AND OBJECTIVES: Gastrointestinal stromal tumors (GISTs) represent the largest group of subepithelial tumors (SET) of the upper gastrointestinal (GI) tract. They may show malignant behavior, in contrast to other SET. Endoscopic ultrasound (EUS) is frequently used to characterize SET. With the introduction of contrast-enhanced ultrasound (CEUS) into EUS (CE-EUS), distinct enhancement patterns can be detected. In the presented study, the characteristic features of CE-EUS in GIST are analyzed and compared with those of other SET...
January 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28206938/a-review-of-sleeve-gastrectomy-specimen-histopathology
#3
Luke A Kinsinger, James C Garber, Oliver Whipple
With the increasing popularity of sleeve gastrectomy, many stomach specimens are being evaluated. Understanding the significance and treatment for unexpected pathology is important. This study examines the incidence of relevant histopathology of sleeve gastrectomy specimens. It evaluates previous data for each histopathology and provides recommendations for treatment. In this study, a retrospective review was performed for 241 patients who underwent sleeve gastrectomy from 2009 to 2014 at a single institution...
November 1, 2016: American Surgeon
https://www.readbyqxmd.com/read/28133332/-multidisciplinary-treatment-for-high-risk-gist-of-the-stomach
#4
Tomo Ishida, Shigeyuki Tamura, Atsushi Takeno, Kohei Murakami, Yohei Nose, Ryota Mori, Yasuo Oneda, Ryuichi Kuwahara, Takuya Sakamoto, Atsushi Naito, Yoshiteru Katsura, Yoshiaki Ohmura, Yoshinori Kagawa, Yutaka Takeda, Takeshi Kato
A 59-year-old man underwent total gastrectomy(with D2 dissection)and cholecystectomy for gastric cancer and a submucosal tumor of the stomach. The specimen was immunohistochemically positive for c-kit, the Ki-67 label index was 10%, and the mitotic count was 20/HPF. Finally, the patient was diagnosed with high-risk gastrointestinal stromal cancer with normal type gastric cancer. After discharge from hospital, we started administration of TS-1 as adjuvant therapy for the gastric cancer. As multiple recurrences of the GIST in the abdomen developed, the patient underwent 3 radical local resections...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133329/-a-case-of-a-laparoscopically-resected-gastrointestinal-stromal-tumor-of-the-stomach
#5
Tomoki Hariu, Yoshihito Nako, Shigeki Yamasaki, Takashi Kitade, Motomi Wakasa, Teruhisa Sonoyama
During treatment for sigmoid colon diverticulitis, a 72-year-old man underwent abdominal computed tomography, which revealed a gastric tumor that was approximately 40mm in diameter. He then underwent a detailed examination after the remission of diverticulitis. The gastric mucosa was found to be unremarkable on gastrointestinal endoscopy. On ultrasonic endoscopy, however, a hypoechoic mass of approximately 40mm in diameter was detected in the fourth layer of the gastric fornix and was believed to be a gastric submucosal tumor(SMT)...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133281/-a-case-of-gist-of-the-stomach-with-long-term-survival-after-multidisciplinary-treatment-including-four-surgical-resections-of-liver-metastases
#6
Masatoshi Kitakaze, Motohiro Hirao, Atsushi Miyamoto, Takuya Hamakawa, Kazuyoshi Yamamoto, Kazuhiro Nishikawa, Sakae Maeda, Mamoru Uemura, Masakazu Miyake, Naoki Hama, Michihiko Miyazaki, Masataka Ikeda, Shoji Nakamori, Hiroki Kiyokawa, Masayuki Mano, Mitsugu Sekimoto
The most frequent relapse site of gastrointestinal stromal tumors(GIST)is the liver. We encountered a patient with longterm survival treated with multidisciplinary treatment, including4 hepatectomies for liver metastases. The patient was a woman aged 69 years at the time of the first medical treatment. She underwent total gastrectomy and S6 segmental hepatec- tomy for a stomach GIST with a hepatic metastasis. The tumor diameter was 24 cm and the mitotic figure was 65/50 HPF. According to the guidelines, it was diagnosed as a high risk GIST based on strong positive immunostaining for CD34 and c-kit...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133274/-resection-of-a-huge-gastrointestinal-stromal-tumor-of-the-stomach-following-neoadjuvant-chemotherapy-with-imatinib
#7
Yoshihiro Sato, Hideaki Karasawa, Takeshi Aoki, Hirofumi Imoto, Naoki Tanaka, Kazuhiro Watanabe, Tomoya Abe, Munenori Nagao, Shinobu Ohnuma, Hiroaki Musha, Masanobu Takahashi, Fuyuhiko Motoi, Takeshi Naitoh, Chikashi Ishioka, Michiaki Unno
We report a case of a huge gastric gastrointestinal stromal tumor(GIST)that was safely resected followingpreoperative imatinib therapy. A 72-year-old woman was hospitalized with severe abdominal distension. Computed tomography revealed a 27×17 cm tumor in the left upper abdominal cavity. The patient was diagnosed with high risk GIST by EUS-FNA. We initiated preoperative adjuvant chemotherapy with imatinib to achieve a reduction of operative risks and functional preservation. After 6 months of chemotherapy, CT showed a reduction in the tumor size and the patient underwent partial gastrectomy and partial resection of the diaphragm...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133241/-the-characteristics-of-patients-with-gist-who-experienced-late-recurrence-after-resection
#8
Noriko Wada, Tsuyoshi Takahashi, Yukinori Kurokawa, Kiyokazu Nakajima, Yasuhiro Miyazaki, Tomoki Makino, Makoto Yamasaki, Shuji Takiguchi, Toru Masuzawa, Toshirou Nishida, Masaki Mori, Yuichiro Doki
The characteristics of patients with gastrointestinal stromal tumor(GIST)who need long-term surveillance after resection remain unclear. We investigated the characteristics of 14 patients with GIST who developed recurrence over 5 years after resection. The most common primary tumor site was the stomach, followed by the rectum and small intestine. We found that 58% of patients had low-risk tumors, and 29% of patients developed recurrence over 10 years after resection. The most common first recurrence site was local, followed by the liver and peritoneum...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28131864/comparison-of-fine-needle-aspiration-and-fine-needle-biopsy-for-eus-guided-sampling-of-suspected-gi-stromal-tumors
#9
Abdul Hamid El Chafic, David Loren, Ali Siddiqui, Rawad Mounzer, Natalie Cosgrove, Thomas Kowalski
BACKGROUND AND AIM: Subepithelial lesions (SEL) are found in about 1% of all esophagogastroduodenoscopy (EGD) procedures, and GI stromal tumors (GISTs) are a type of SEL commonly encountered. Although the majority of SELs are benign, GISTs have malignant potential, making a definitive diagnosis important. Currently, the criterion standard for the diagnosis of GISTs is EUS-directed fine-needle aspiration (EUS-FNA). The definitive diagnosis of GISTs relies upon immunohistochemical (IHC) staining, which depends on enough tissue being submitted to the pathologist...
January 25, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28114506/surgical-management-of-adolescents-and-young-adults-with-gastrointestinal-stromal-tumors-a-us-population-based-analysis
#10
Katherine E Fero, Taylor M Coe, Paul T Fanta, Chih-Min Tang, James D Murphy, Jason K Sicklick
Importance: There is a dearth of population-based evidence regarding outcomes of the adolescent and young adult (AYA) population with gastrointestinal stromal tumors (GISTs). Objectives: To describe a large cohort of AYA patients with GISTs and investigate the effect of surgery on GIST-specific survival (GSS) and overall survival (OS). Design, Setting, and Participants: This retrospective cohort study of 392 AYA patients and 5373 older adult (OA) patients in the Surveillance, Epidemiology, and End Results (SEER) database with GISTs histologically diagnosed from January 1, 2001, through December 31, 2013, with follow-up through December 31, 2015, compared the baseline characteristics of AYA (13-39 years old) and OA (≥40 years old) patients and among AYA patients stratified by operative management...
January 18, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28079762/robotic-versus-laparoscopic-gastric-resection-for-primary-gastrointestinal-stromal-tumors-5-cm-a-size-matched-and-location-matched-comparison
#11
Nicola de'Angelis, Pietro Genova, Aurelien Amiot, Cecile Charpy, Mara Disabato, Ajay P Belgaumkar, Ali Chahrour, Francois Legou, Daniel Azoulay, Francesco Brunetti
This study compared robotic (RR) and laparoscopic resection (LR) for primary gastrointestinal stromal tumors (GISTs) of the stomach >5 cm. Twelve consecutive patients who underwent RR from 2012 to 2015 were matched for tumor size and location with 24 patients who underwent LR from 2000 to 2012. The median tumor size was 7.1 cm (range, 5.5 to 11.5). GISTs were resected by wedge resection (91.7%) or distal gastrectomy. The median RR operative time was longer than that of LR (162.5 vs. 130 min, respectively; P=0...
February 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28034324/p16-overexpression-in-braf-mutated-gastrointestinal-stromal-tumors
#12
Shan-Shan Shi, Xuan Wang, Qiu-Yuan Xia, Qiu Rao, Qin Shen, Sheng-Bin Ye, Rui Li, Qun-Li Shi, Zhen-Feng Lu, Heng-Hui Ma, Xiao-Jun Zhou
BACKGROUND: The aims of this study were to analyze the histopathology, immunophenotype, molecular features, and prognosis in cases of BRAF-mutated gastrointestinal stromal tumors (GISTs) and to examine the p16 expression in these tumors, and further discuss its effects on tumor formation and progression. METHODS: In all, 283 GIST cases (201 KIT mutants, 12 PDGFRA mutants and 70 wild-type) from the 2010 to 2014 surgical pathology files of the Department of Pathology at Nanjing Jinling Hospital were analyzed for mutations in BRAF exon 15...
December 30, 2016: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28006721/wide-local-excision-for-anal-gist-a-case-report-and-review-of-literature
#13
Mohamed Azzaza, Houssem Ammar, Nihed Abdessayed, Rahul Gupta, Mohamed Said Nakhli, Amine Chhaider, Nafis Abdennaceur, Ali Ben Ali
INTRODUCTION: Gastrointestinal stromal tumors (GIST) are tumors of mesenchymal origin commonly detected in stomach and small bowel. GIST arising primarily from the anal canal is extremely rare. Due to the malignant potential, these tumors are treated with radical surgery like abdominoperineal resection. But with the advent of imatinib therapy and a better understanding of the tumor biology, some cases have been successfully treated with wide local excision. PRESENTATION OF CASE: We describe a case of a 70-year-old lady presenting with a 2cm mass in the anal canal...
December 2, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27994335/perforated-gastrointestinal-stromal-tumor-of-the-meckel-s-diverticulum-a-case-report-and-review-of-literature
#14
Ishwar R Hosamani, Srinivas Kodaganur, S M Chaukimath
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the GI tract, they have a wide spectrum of clinical manifestations, and a small proportion of them present as an acute abdomen due to obstruction, perforation, or hemoperitoneum. We present a case of a perforated GIST of the Meckel's diverticulum and review the current literature on perforated GISTs. We ran a search on Pubmed and Google Scholar with the following terms "perforated GIST," "perforated Meckel's diverticulum," "GIST with peritonitis," and "GIST in Meckel's diverticulum...
October 2016: Indian Journal of Surgery
https://www.readbyqxmd.com/read/27964865/gastrointestinal-stromal-tumours-gists-a-descriptive-study-on-29-cases
#15
Lamine Hamzaoui, Mouna Medhioub, Mahdi Bouassida, Moufida Mahmoudi, Souhaiel El Bouchtili, Heykal Ezzine, Emna Chelbi, Hassen Touinsi, Mohamed Mousadek Azouz
BACKGROUND AND STUDY AIM: Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumours of the gastrointestinal tract, originating from Cajal cells in different sites of the digestive tract. The aim of the study is to report on epidemiological, clinical, histological, and therapeutic characteristics of GISTs. PATIENTS AND METHODS: A retrospective descriptive study of 29 cases of GIST in gastroenterology and general surgery departments of Mohamed Tahar Maamouri Hospital (Nabeul, Tunisia) was conducted from January 2005 to March 2012...
December 2016: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/27928803/-efficacy-analysis-of-laparoscopic-curve-resection-for-gastric-gastrointestinal-stromal-tumor
#16
Minzhe Li, Jian Shen, Yanfu Du, Dehong Xie, Hao Qu, Yudong Zhang
OBJECTIVE: To evaluate the feasibility and safety of curved cutter stapler in laparoscopic curve resection for gastric gastrointestinal stromal tumor(GIST). METHODS: A retrospective clinical study was carried out with the clinical data of 19 cases of gastric GIST, who received laparoscopic curve resection with the curved cutter stapler during the period between January 2015 and December 2015 in Department of General Surgery, Beijing Chaoyang Hospital, Capital Medical University...
November 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27928802/-clinical-characteristics-and-prognosis-analysis-of-119-cases-with-giant-gastrointestinal-stromal-tumor
#17
Peng Zhang, Xiangyu Zeng, Jinbo Gao, Weizhen Liu, Xiaoming Shuai, Ke Liu, Xinghua Liu, Ming Cai, Kailin Cai, Guobin Wang, Kaixiong Tao
OBJECTIVE: To investigate the clinical characteristics, diagnosis and treatment as well as prognostic factors of the giant gastrointestinal stromal tumor (GIST). METHODS: Clinical data of 235 patients with high risk GIST treated in the Union Hospital, Tongi Medical College, Huazhong University of Science and Technology between January 2005 and July 2015 were retrospectively analyzed. Patients were divided into giant GIST group (diameter equal to or larger than 10 cm, 119 cases) and high risk group (diameter less than 10 cm, 116 cases) according to tumor size...
November 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27928797/-changes-of-diagnosis-and-treatment-for-gastrointestinal-stromal-tumors-during-a-18-year-period-in-four-medical-centers-of-china
#18
Haibo Qiu, Peng Zhang, Xingyu Feng, Tao Chen, Xiaowei Sun, Jiang Yu, Zhijing Chen, Yong Li, Kaixiong Tao, Guoxin Li, Zhiwei Zhou
OBJECTIVE: To elucidate the historic and current diagnosis and treatment status of gastrointestinal stromal tumor (GIST) in the Chinese population based on four high volume databases. METHODS: Clinicopathological data of GIST patients with follow-up information between January 1998 and December 2015 from Sun Yat-sen University Cancer Center, Union Hospital of Huazhong University of Science and Technology, Southern Medical University Nanfang Hospital and Guangdong General Hospital were retrospectively analyzed...
November 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27928796/-current-status-of-surgical-treatment-of-gastric-gastrointestinal-tumors-a-national-multi-center-retrospective-study
#19
Xingyu Feng, Renjie Li, Peng Zhang, Tao Chen, Haibo Qiu, Yongjian Zhou, Chunyan Du, Xiaonan Yin, Fang Pan, Guoliang Zheng, Xiaowei Sun, Jiang Yu, Zhijing Chen, Yan Zhao, Xiufeng Liu, Jian Li, Bo Zhang, Ye Zhou, Changming Huang, Zhiwei Zhou, Guoxin Li, Kaixiong Tao, Yong Li
OBJECTIVE: To retrospectively analyze the clinicopathology of patients with gastric gastrointestinal stromal tumor(gGIST) who underwent radical excision within 18 years in 10 domestic medical centers in order to understand the status of domestic surgical treatment of gGIST. METHODS: Clinicopathological data of gGIST patients undergoing radical excision in 10 medical centers from January 1998 to January 2016 were collected, and their operational conditions, postoperative adjuvant therapy, gene detection and survival were analyzed retrospectively...
November 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27924391/our-experience-with-laparoscopic-partial-gastrectomy-by-the-lift-and-cut-method-for-gastric-gastrointestinal-stromal-tumor-with-maximal-preservation-of-the-remnant-stomach
#20
Shintaro Okumura, Seiichiro Kanaya, Hisahiro Hosogi, Takeshi Ito, Susumu Miura, Toshihiro Okada, Norihiro Shimoike, Shin Akagawa, Hironori Kawada, Akira Arimoto
BACKGROUND: Wedge resection is the most commonly used method in laparoscopic partial gastrectomy for gastric gastrointestinal stromal tumor (GIST). However, this method can involve inadvertent resection of additional gastric tissue and cause gastric deformation. To minimize the volume of resected gastric tissue, we have developed a laparoscopic partial gastrectomy with seromyotomy which we call the 'lift-and-cut method' for gastric GIST. Here, we report a case series of this surgery. METHOD: First, the seromuscular layer around the tumor is cut...
December 6, 2016: Surgical Endoscopy
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