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Stomach GIST

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https://www.readbyqxmd.com/read/29239342/transgastric-submucosal-excision-of-small-to-medium-sized-gastrointestinal-stromal-tumours-by-pure-minimally-invasive-approach
#1
Manash Ranjan Sahoo, Sumeet Deshpande, Shameel Ahmmed
AIM: The aim of this study is to evaluate the results of a single and common approach for transgastric submucosal excision of small- to medium-sized gastrointestinal stromal tumours (GIST) having different locations in upper two-third of the stomach by pure minimally invasive approach. MATERIALS AND METHODS: A retrospective study from February 2012 to January 2015 on 11 patients was conducted including both male and female. Their age ranged from 40 to 65 years. All were subjected to laparoscopic transgastric submucosal excision of GIST in upper two-third of the stomach with 1 cm margin having different locations in stomach...
January 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29237476/giant-gastrointestinal-stromal-tumor-with-predominantly-cystic-changes-a-case-report-and-literature-review
#2
Liying Wang, Libin Liu, Zhaohui Liu, Yueli Tian, Zhe Lin
BACKGROUND: Gastrointestinal stromal tumors (GISTs) rarely present with predominantly cystic changes. Here, we report a case of giant GIST of the stomach with predominantly cystic changes in a 74-year-old female patient. CASE PRESENTATION: The tumor was 10 cm × 15 cm in size and positive for CD117, H-caldesmon, and DOG-1. Complete surgical resection was performed without regional lymphadenectomy. The patient recovered uneventfully and no recurrence occurred...
December 13, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29207963/two-staging-systems-for-gastrointestinal-stromal-tumors-in-the-stomach-which-is-better
#3
Chul Hong Park, Gwang Ha Kim, Bong Eun Lee, Geun Am Song, Do Youn Park, Kyung Un Choi, Dae Hwan Kim, Tae Yong Jeon
BACKGROUND: The prognosis of a gastrointestinal stromal tumor (GIST) is influenced by its anatomic site; however, few studies on the prognosis of gastric GISTs have been reported. The aims of this study were to evaluate long-term prognoses of patients who underwent surgical resection for gastric GISTs and to compare the clinical efficacy of two staging systems: the National Institutes of Health (NIH) consensus criteria and the 7th Union for International Cancer Control/American Joint Committee on Cancer (UICC/AJCC) tumor-node-metastasis (TNM) staging system...
December 6, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29207774/a-diagnostic-surprise-for-a-right-iliac-fossa-mass-a-perforated-ileal-gastrointestinal-stromal-tumour
#4
J Sanjay Prakash, Anita Samraj, G Sabarish Kumar, R Vijai
Gastrointestinal Stromal Tumours (GISTs) are tumours of the gut found mostly in stomach and small intestine. The complications are Gastrointestinal (GI) bleeding, obstruction, pain and rarely perforation. We are reporting an abnormal presentation of GIST masquerading as an acute abdomen with Right Iliac Fossa (RIF) mass in 60-year-old lady. Contrast Enhanced Computed Tomography (CECT) of abdomen revealed a peripherally enhancing encapsulated abscess in RIF in close contact with base of caecum and adjacent peritonitis suggesting caecal perforation...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29175648/prognostic-significance-of-neutrophil-to-lymphocyte-ratio-in-patients-with-gastrointestinal-stromal-tumors-a-meta-analysis
#5
REVIEW
Xiao-Feng Luo, Lin-Hua Zhou
BACKGROUND: The neutrophil to lymphocyte ratio (NLR) is reported to be a prognostic factor in multiple malignancies. However, its prognostic value in patients with gastrointestinal stromal tumors (GISTs) remains controversial. This study aims to evaluate the prognostic value of preoperative NLR in GISTs. METHODS: MEDLINE, EMBASE, and, Cochrane databases were searched until February 2017. Eligible articles were defined as studies assessing the prognostic role of preoperative NLR in GISTs...
November 23, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29167690/synchronous-gists-associated-with-multiple-sporadic-tumors-a-case-report
#6
Danila Comandini, Azzurra Damiani, Alessandro Pastorino
Gastrointestinal stromal tumors (GISTs) are rare neoplasms, but they also represent the most common mesenchymal tumors of the gastrointestinal tract originating from the cell of Cajal. GIST incidence ranges around 1% of all gastrointestinal malignancies. Approximately 5% of all GISTs have a hereditary etiology. The remaining 95% of GISTs are considered sporadic events, with up to 75% of cases driven by a constitutional activation of the c-KIT proto-oncogene. GISTs are generally solitary lesions. Nonetheless, multiple sporadic GISTs can occur and present as synchronous or metachronous tumors, usually associated with familial GIST...
2017: Drugs in Context
https://www.readbyqxmd.com/read/29151288/-the-value-of-18-f-fdg-pet-ct-imaging-in-predicting-the-malignant-potential-of-gist
#7
S X Li, M D Tang, D Y Lin, D J Liu, Q H Lyu, J P Zhang, Z H Cai
Objective: To evaluate the value of (18)F-FDG PET-CT in predicting the malignant potential of Gastrointestinal Stromal Tumors (GIST). Methods: The clinical and pathological features of 31 patients with GIST confirmed by surgery or biopsy were retrospectively analyzed. The malignant potential of GIST before treatment was assessed by (18)F-FDG PET-CT. The GIST risk classification was graded according to the Standard revised by the National Institutes of Health (NIH) in 2008. The relationship between the maximal standard uptake value (SUVmax) and GIST risk classification, tumor diameter, Ki-67 index, and mitotic count were analyzed respectively...
November 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29082324/left-adrenal-tumor-disappeared-outside-a-field-of-vision-during-laparoscopic-surgery-the-true-identity-was-gastrointestinal-stromal-tumor
#8
Hiroshi Ushida, Hirofumi Goto, Satoshi Ishitoya, Hiroyuki Onishi
Background: We report a case of gastrointestinal stromal tumor (GIST) mimicking a left adrenal tumor. Case Presentation: A 62-year-old female was referred to our hospital for the treatment of left adrenal tumor of 2.8 × 2.3 cm incidentally found during her annual checkup. The preoperative diagnosis based on upper gastroscopy and imaging complete examinations was nonfunctional left adrenal tumor possessing malignant potential. Transperitoneal laparoscopic left adrenalectomy was performed. However, the tumor was not found in the excised adrenal gland that had been completely removed during surgery...
2017: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29062458/bariatric-surgery-and-incidental-gastrointestinal-stromal-tumors-a-single-center-study-vsj-competition-1-st-place
#9
Maciej Walędziak, Anna Różańska-Walędziak, Piotr K Kowalewski, Michał R Janik, Jakub Brągoszewski, Krzysztof Paśnik
INTRODUCTION: Gastrointestinal stromal tumors (GISTs), originating from Cajal cells, are most commonly located in the stomach; therefore they can be found in the specimens excised during bariatric operations. The global prevalence of GISTs is about 130 cases per million population. Morbidity differs depending on geographical latitude. Although surgery is the treatment of choice for GISTs, 40-50% of patients after radical surgical treatment will have a relapse or metastases. AIM: To analyze the incidence of GISTs in patients undergoing bariatric surgery and to verify whether an operation performed according to the bariatric protocol is oncologically radical in case of GIST...
September 2017: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/29062454/laparoscopic-total-gastrectomy-for-a-giant-gastrointestinal-stromal-tumor-gist-with-acute-massive-gastrointestinal-bleeding-a-case-report
#10
Mohammad Kermansaravi, Samaneh Rokhgireh, Sattar Darabi, Abdolreza Pazouki
Gastrointestinal stromal tumors (GISTs) include 80% of gastrointestinal mesenchymal tumors that originate from interstitial Cajal cells and include 0.1-3% of GI malignancies, and the stomach is the most commonly involved organ. The only potentially curative treatment is surgical resection with clear margins. Although laparoscopic resection of small GISTs is a standard treatment, there is controversy about laparoscopic surgical resection for large and giant GISTs. A 52-year-old woman, a known case of large GIST of the stomach that was under neoadjuvant imatinib therapy, was admitted to the emergency department due to acute massive gastrointestinal bleeding (GIB)...
September 2017: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/28975117/clinical-practice-and-outcomes-in-advanced-gastrointestinal-stromal-tumor-experience-from-an-indian-tertiary-care-center
#11
Subhadeep Bose, Anant Ramaswamy, Arvind Sahu, Omshree Shetty, Saurabh S Zanwar, Jimmy Mirani, Chaitali Nashikkar, Vikas Ostwal
BACKGROUND: Management of advanced Gastrointestinal stromal tumors (GIST) has been revolutionized with the use of Imatinib guided by mutation analysis. Data from India remains scarce. MATERIALS AND METHODS: Patients with metastatic GIST who were treated at Department of Gastro-intestinal & Hepaticopancreaticobiliary Oncology Unit at Tata Memorial Hospital, Mumbai between December, 2004 and December 2015 were included in the analysis. Clinical and radiological data was retrieved from stored medical records and charts...
July 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28971180/an-infrequent-case-of-intussusception-caused-by-gastrointestinal-stromal-tumor-in-an-adult-patient
#12
Mehmet Mahir Fersahoglu, Ayse Tuba Fersahoglu, Nuriye Esen Bulut, Burcu Seher Anil Narin, Sinan Tezer
Intussusception may occur anywhere in the gastrointestinal system. Unlike its idiopathic childhood counterpart, it is uncommon during adult life and a definitive cause is usually found; almost half of cases develop with malignancy. Gastrointestinal stromal tumors (GIST) originate from interstitial Cajal cells of the gastrointestinal tract. They more frequently occur in the stomach and small intestines, and often grow extraluminally, making it unlikely to cause an obstruction or bleeding. Presently described is an unusual instance of ileo-ileal intussusception due to GIST...
2017: Northern Clinics of Istanbul
https://www.readbyqxmd.com/read/28931294/-carney-triad
#13
L Fiala, I Kocáková, R Šimůnek, E Krejčí, I Babánková, R Šefr
Carney triad is a synchronous or metachronous association of gastric gastrointestinal stromal tumors (GIST), pulmonary chondroma and extra-adrenal paraganglioma. The majority of patients have only one or two components of the triad, all three tumors being found in only about 2% of the patients at the time of the first diagnosis. The most common combination is gastric and pulmonary tumors. We report a case of Carney triad which was diagnosed at Masaryk Memorial Cancer Institute. A 57-year-old female patient with a history of gastric resection for leiomyosarcoma at the age of 14 and with an unclear pulmonary lesion evident on chest X-ray since as early as 2003...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/28900995/-association-between-genetic-polymorphisms-and-variation-of-imatinib-pharmacokinetics-in-gastrointestinal-stromal-tumors
#14
Haibo Qiu, Wei Zhuang, Xueding Wang, Min Huang, Zhiwei Zhou
OBJECTIVE: To investigate the influence of metabolic enzymes polymorphisms on variations of imatinib (IM) pharmacokinetics in gastrointestinal stromal tumors (GIST) patients. METHODS: Clinical data of 118 Chinese GIST patients receiving 400 mg/d IM at Sun Yat-sen University Cancer Center between 2014 and 2016 were retrospectively analyzed. The plasma concentration of imatinib mesylate(IM) and its main metabolic N-demethyl imatinib (NDI) were determined by LC-MS/MS...
September 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28900993/-comparison-of-modified-nih-and-afip-risk-stratification-criteria-for-gastrointestinal-stromal-tumors-a-multicenter-retrospective-study
#15
Tao Chen, Haibo Qiou, Xingyu Feng, Peng Zhang, Liangying Ye, Yanfeng Hu, Hao Liu, Jiang Yu, Kaixiong Tao, Yong Li, Zhiwei Zhou, Guoxin Li
OBJECTIVE: To evaluate and compare the value of Modified NIH criteria and AFIP criteria for the risk classification of gastrointestinal stromal tumors (GIST). METHODS: Clinicopathological and follow-up data of 539 patients diagnosed as primary GIST with or without irregular tyrosine kinase inhibitors in the Nanfang Hospital(n=143), Sun Yat-sen University Cancer Center (n=138), Guangdong Provincial People's Hospital (n=102) and Wuhan Union Hospital (n=156) from January 2012 to December 2015 were retrospectively analyzed...
September 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28877809/a-review-of-sleeve-gastrectomy-specimen-histopathology
#16
Luke A Kinsinger, James C Garber, Oliver Whipple
With the increasing popularity of sleeve gastrectomy, many stomach specimens are being evaluated. Understanding the significance and treatment for unexpected pathology is important. This study examines the incidence of relevant histopathology of sleeve gastrectomy specimens. It evaluates previous data for each histopathology and provides recommendations for treatment. In this study, a retrospective review was performed for 241 patients who underwent sleeve gastrectomy from 2009 to 2014 at a single institution...
November 1, 2016: American Surgeon
https://www.readbyqxmd.com/read/28871595/role-of-immune-microenvironment-in-gastrointestinal-stromal-tumors
#17
Andrew M Blakely, Andres Matoso, Pallavi A Patil, Ross Taliano, Jason T Machan, Thomas J Miner, Kara A Lombardo, Murray B Resnick, Li-Juan Wang
INTRODUCTION: The immune microenvironment is a prognostic factor for various malignancies. The significance of key players of this immune microenvironment including tumor-infiltrating lymphocytes and expression of programmed death-ligand 1 (PD-L1), indoleamine-2,3-dioxygenase (IDO), and tryptophanyl-tRNA synthetase (WARS) in gastrointestinal stromal tumors (GISTs) is largely unknown. METHODS: Tissue microarrays were constructed from pathology files, 1996-2016. Immunohistochemistry for PD-L1, IDO, WARS was correlated with tumor size, mitoses, and outcomes...
September 4, 2017: Histopathology
https://www.readbyqxmd.com/read/28839880/gastrointestinal-stromal-tumours-gists-an-insight-into-clinical-practice-with-review-of-literature
#18
M J McDonnell, S Punnoose, Y K S Viswanath, N J Wadd, A Dhar
BACKGROUND: Gastrointestinal stromal tumours (GISTs) are rare mesenchymal tumours of the gastrointestinal tract. We retrospectively reviewed the clinical management of all patients with GIST presenting to a regional multidisciplinary upper gastrointestinal cancer group in the north of England. METHODS: Clinical, pathological, immunohistochemical treatment strategies, follow-up and outcome data on all patients with GIST between 2007 and 2012 were reviewed. Tumours were categorised by risk according to the National Institutes of Health (NIH) and AFIP models...
January 2017: Frontline Gastroenterology
https://www.readbyqxmd.com/read/28799152/-gastric-schwannoma-rare-differenzial-diagnosis-of-acute-upper-gastrointestinal-gi-bleeding
#19
Orestis Lyros, Stephan Schickel, Katrin Schierle, Albrecht Hoffmeister, Ines Gockel
Schwannomas are benign tumors derived from Schwann cells and their typical site of origin is the subcutaneous tissue of the extremities. Gastrointestinal localization of Schwannomas is extremely rare and the stomach is the prevalent site. Gastric schwannomas primarily occur in the gastric submucosa and are usually asymptomatic.We present a rare case of a solitary gastric schwannoma in a 51-year old male, which initially manifested with hematemesis by acute upper gastrointestinal (GI) bleeding. The upper GI-Endoscopy revealed a gastric submucosal tumor, 7 cm in size, located in the proximal corpus and fundus...
August 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28796048/clinicopathologic-study-of-succinate-dehydrogenase-deficient-gastrointestinal-stromal-tumors-a-single-institutional-experience-in-china
#20
Weizhen Liu, Xiangyu Zeng, Xiuli Wu, Jun He, Jinbo Gao, Xiaoming Shuai, Guobin Wang, Peng Zhang, Kaixiong Tao
Gastrointestinal stromal tumors (GISTs) that are not driven by kinase mutations, as are most GISTs, often show loss of function of the succinate dehydrogenase (SDH) complex and are considered SDH-deficient GISTs. SDH-deficient GISTs share many distinct characteristics compared with conventional GISTs. However, data regarding these characteristics, particularly among Asian people, are relatively limited. The objective of this study was to characterize the clinicopathologic characteristics, treatment, and prognosis of these uncommon GISTs...
August 2017: Medicine (Baltimore)
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