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Stomach GIST

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https://www.readbyqxmd.com/read/29650923/-a-case-of-gastric-gist-with-pathological-complete-response-achieved-by-long-term-chemotherapy-with-imatinib-mesylate
#1
Junya Kondo, Hikari Chijimatsu, Taiki Kijima, Yukiko Nagashima, Hideto Hayashi, Katsuhiko Morita, Kouichiro Sakata, Mihoko Setoguchi
A 78-year-old woman was diagnosed with a gastrointestinal stromal tumor(GIST)of the stomach, gradually increasing from 5 years prior. The tumor was suspected to invade the pancreatic body tail and spleen, as observed with computed tomography. Because the patient refused to undergo resection, we administered imatinib mesylate for 6 years. Since early rectal cancer was revealed, the patient was referred for resection and underwent laparoscopic low anterior resection and partial gastrectomy. Histopathologically, the tumor was replaced by tissues with myxomatous changes, and no viable tumor cells were detected...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29643676/discordant-primary-resistance-to-imatinib-mesylate-in-the-same-individual-and-splenic-involvement-in-recurring-gastric-gastrointestinal-stromal-tumors-assessment-by-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#2
Preeti Fargose, Sandip Basu
Discordant primary resistance and response of the metastatic lesions in the same individual coupled with splenic involvement in gastrointestinal stromal tumors (GISTs) are relatively uncommon. We herein report such a case of recurring GIST of the stomach that presented with the involvement of spleen with 18 F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) imaging documentation. Ultrasonography-guided fine needle aspiration cytology from the splenic and paravesical lesions demonstrated metastatic spindle cell tumor consistent with diagnosis of metastasis from GIST of the stomach...
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29629225/igg4-related-disease-in-the-stomach-which-was-confused-with-gastrointestinal-stromal-tumor-gist-two-case-reports-and-review-of-the-literature
#3
Ho Seok Seo, Yoon Ju Jung, Cho Hyun Park, Kyo Young Song, Eun Sun Jung
Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated fibro-inflammatory disorder characterized by specific pathological findings and elevated serum IgG4 level. IgG4-RD in the stomach is rare, and occasionally diagnosed as gastric subepithelial tumor (SET) by endoscopy or computed tomography scan. Two female patients in the age group of 40-50 years were diagnosed with 4 cm sized gastric SET. One underwent laparoscopic gastric wedge resection. Another one had a history of subtotal gastrectomy for early gastric cancer and idiopathic thrombocytopenic purpura with oral steroids administration...
March 2018: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29595183/gastrointestinal-stromal-tumours-of-stomach-robot-assisted-excision-with-the-da-vinci-surgical-system-regardless-of-size-and-location-site
#4
Niccolo Furbetta, Matteo Palmeri, Simone Guadagni, Gregorio Di Franco, Desirée Gianardi, Saverio Latteri, Emanuele Marciano, Andrea Moglia, Alfred Cuschieri, Giulio Di Candio, Franco Mosca, Luca Morelli
AIMS: The role of minimally invasive surgery of gastrointestinal stromal tumours (GISTs) of the stomach remains uncertain especially for large and/or difficult located tumours. We are hereby presenting a single-centre series of robot-assisted resections using the da Vinci Surgical System (Si or Xi). SUBJECTS AND METHODS: Data of patients undergoing robot-assisted treatment of gastric GIST were retrieved from the prospectively collected institutional database and a retrospective analysis was performed...
March 23, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29575341/coexistence-of-gastrointestinal-stromal-tumor-and-leiomyosarcoma-of-the-stomach-presenting-as-a-collision-tumor-a-case-report-and-review-of-literature
#5
Hiroki Kitagawa, Mayumi Kaneko, Mikihiro Kano, Yuta Ibuki, Vishwa Jeet Amatya, Yukio Takeshima, Naoki Hirabayashi, Seiichi Hirota
Collision tumor of the stomach is rare. We report a rare case of a gastric collision tumor consisting of gastrointestinal stromal tumors (GISTs) and leiomyosarcoma (LMS). Computed tomography scan revealed a 15 cm sized mass in the posterior wall of the body of the stomach. Gross examination of the wedge resection specimen showed the tumor located in the muscularis propria with extramural protrusion into the peritoneal cavity and the gastric cavity with geographic necrosis, hemorrhage, and mucosal ulceration...
March 25, 2018: Pathology International
https://www.readbyqxmd.com/read/29558033/management-of-gastrointestinal-stromal-tumors-a-10-year-experience-of-a-single-surgical-department
#6
Dariusz Janczak, Jacek Rać, Wiktor Pawłowski, Tadeusz Dorobisz, Agnieszka Ziomek, Dawid Janczak, Michał Leśniak, Mariusz Chabowski
BACKGROUND: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive system. The primary location of GISTs is mainly the gastrointestinal system. Clinical symptoms are nonspecific and mainly depend on the location and size of the tumor. OBJECTIVES: The aim of this study was to conduct a clinical and pathological analysis of 18 cases of GISTs from the medical records of the Department of Surgery at the 4th Military Teaching Hospital in Wrocław, Poland...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29545720/prognostic-factors-of-primary-gastrointestinal-stromal-tumors-a-cohort-study-based-on-high-volume-centers
#7
Xuechao Liu, Haibo Qiu, Peng Zhang, Xingyu Feng, Tao Chen, Yong Li, Kaixiong Tao, Guoxin Li, Xiaowei Sun, Zhiwei Zhou, On Behalf Of China Gastrointestinal Stromal Tumor Study Group Cn-Gist
Objective: We aimed to evaluate the clinicopathologic characteristics, immunohistochemical expression and prognostic factors of patients with primary gastrointestinal stromal tumors (GISTs). Methods: Data from 2,570 consecutive GIST patients from four medical centers in China (January 2001-December 2015) were reviewed. Survival curves were constructed by the Kaplan-Meier method, and Cox regression models were used to identify independent prognostic factors. Results: Of the included patients, 1,375 (53...
February 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29507015/the-mass-effect-of-a-slowly-growing-gist
#8
Deepali Prakash, Leandro Siragusa, Saj Wajed, Antonio Manzelli
Gastrointestinal stromal tumours (GISTs) are typically defined as solid masses arising from the GI tract, most commonly from the stomach and small intestine. They seldom present in a cystic form. Management of cystic masses arising from the GI tract may pose a diagnostic predicament. We had one such case that presented itself with complaints of a slow growing intra-abdominal mass. An ultrasound scan demonstrated a thick-walled cystic lesion arising from the pelvis. Further imaging evaluations in the form of a CT scan revealed a complex large cystic mass arising from left upper quadrant (see Figure 1)...
March 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29499127/submucosal-tunnel-endoscopic-resection-for-extraluminal-tumors-a-novel-endoscopic-method-for-en-bloc-resection-of-predominant-extraluminal-growing-subepithelial-tumors-or-extra-gastrointestinal-tumors-with-videos
#9
Ming-Yan Cai, Bo-Qun Zhu, Mei-Dong Xu, Wen-Zheng Qin, Yi-Qun Zhang, Wei-Feng Chen, Marie Ooi, Quan-Lin Li, Li-Qing Yao, Ping-Hong Zhou
BACKGROUND AND AIM: The management of subepithelial tumors with a predominant extraluminal growth pattern or extra-gastrointestinal (GI) tumors can be challenging and traditionally requires a surgical resection that is not only invasive but may carry a significant risk of morbidity and mortality. We aim to assess the feasibility, safety and efficacy of a novel endoscopic technique termed as submucosal tunnel endoscopic resection for Extraluminal Tumors (STER-ET). METHODS: We prospectively enrolled patients who underwent STER-ET for gastrointestinal subepithelial tumors with a predominant extraluminal growth pattern or extra-GI tumors located at the level of cardia or the proximal part of the lesser curvature of the stomach seen on cross-sectional imaging between January 2016 and March 2017...
February 27, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29487722/prognostic-role-of-the-primary-tumour-site-in-patients-with-operable-small-intestine-and-gastrointestinal-stromal-tumours-a-large-population-based-analysis
#10
Hua Ye, Hua Xin, Qi Zheng, Qijun Shen, Wenyu Dai, Feng Wu, Cheng Zheng, Ping Chen
The postoperative recurrence risk of gastrointestinal stromal tumour (GIST) should be estimated when considering adjuvant systemic therapy. Previous studies in the literature have suggested that small intestinal GISTs are more aggressive than gastric GISTs. We assessed the prognostic role of the primary tumour site in patients with operable GIST to compare the outcomes of gastric and small intestinal GISTs over a decade of treatment. The Surveillance, Epidemiology, and End Results (SEER) database was queried for cases of gastric and small intestinal GISTs between 2004 and 2014 using the GIST-specific histology code (ICD-O-3 code 8936), and only patients with tissues sampled by surgical resection were selected for this study...
January 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29483926/the-effect-of-marital-status-on-survival-of-patients-with-gastrointestinal-stromal-tumors-a-seer-database-analysis
#11
Wei Song, Chuan Tian
Background: Marital status has been reported to be a prognostic factor in multiple malignancies. However, its prognostic value on gastrointestinal stromal tumors (GISTs) have not yet been determined. The objective of the present analysis was to assess the effects of marital status on survival in patients with GISTs. Methods: The Surveillance, Epidemiology, and End Results (SEER) database was used to analyze 6195 patients who were diagnosed with GISTs from 2001 to 2014...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29478742/clinical-and-pathological-features-of-small-gist-%C3%A2-2-cm-what-is-their-prognostic-value
#12
Juan Ángel Fernández, Álvaro Jesús Gómez-Ruiz, Vicente Olivares, Belén Ferri, Maria Dolores Frutos, Teresa Soria, Pedro José Gil, Gloria Torres, Pascual Parrilla
INTRODUCTION: Small GIST (<2 cm) are tumors whose biological behavior is benign and frequently involutes. Despite their increasing incidence, few studies have addressed the characteristics of these GIST. The aim of this work is to clarify the management of this entity. PATIENTS AND METHOD: The characteristics of ≤2 cm GIST were initially described, and then compared with those >2 cm. This series comprises 104 patients and they were divided according to tumor size in 4 groups: tumors which are ≤2 cm (group 1, G1), >2 and ≤ 5 cm (G2), >5 and ≤ 10 cm (G3) and >10 cm (G4)...
February 5, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29443783/giant-gist-of-the-stomach-a-successful-case-of-safe-resection-with-preoperative-simulation-using-three-dimensional-ct-angiography-case-report
#13
Kentaro Matsuo, Masaya Inoue, Yasutsugu Shirai, Tatsuki Kataoka, Shuji Kagota, Kohei Taniguchi, Sang-Woong Lee, Kazuhisa Uchiyama
RATIONALE: We report a very rare case of safely resectable giant gastrointestinal stromal tumor (GIST) with preoperative three-dimensional computed tomography (3D-CT) angiography in spite of no neoadjuvant treatment. PATIENT'S CONCERN: A 71-year-old woman presented to our hospital with an abdominal giant tumor. As this giant tumor could not be accurately diagnosed by preoperative investigation, we had to perform her surgical treatment without neoadjuvant treatment...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29441371/gastrointestinal-stromal-tumor-of-the-esophagus-current-issues-of-diagnosis-surgery-and-drug-therapy
#14
REVIEW
Jun Hihara, Hidenori Mukaida, Naoki Hirabayashi
Gastrointestinal stromal tumors (GISTs) often arise in the stomach and small intestine, while esophageal GISTs are rare. Due to their rarity, clinicopathological data on esophageal GISTs are extremely limited, and this results in a lack of clear recommendations concerning optimal surgical management for esophageal GISTs. It is difficult to distinguish esophageal GIST from leiomyoma, the most frequent esophageal mesenchymal tumor, prior to resection, because the two types of tumors appear similar on computed tomography (CT), endoscopic ultrasound (EUS), and 18F-fluorodeoxyglucose positron emission tomography (FDG-PET)...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29434135/multiple-synchronous-sporadic-gastrointestinal-stromal-tumors-in-the-stomach-and-jejunum
#15
Mami Tokunaga, Sohachi Nanjo, Hiroki Yoshita, Haruka Fujinami, Tohru Watanabe, Yoko Ishii, Saito Kobayashi, Momoko Akashi, Hiroaki Takagi, Hiroshi Mihara, Shinya Kajiura, Takayuki Ando, Isaya Hashimoto, Shozo Hojo, Tomoyuki Okumura, Toshiro Sugiyama
A 77-year-old patient was admitted to our hospital for the further examination of melena. A computed tomography scan detected two submucosal tumors (SMTs) in the stomach and jejunum. Double-balloon endoscopy revealed the presence of a delle on the jejunal SMT, suggesting that the SMT was the origin of the gastrointestinal bleeding. Both tumors were surgically resected and subsequently diagnosed via histology as gastrointestinal stromal tumors (GISTs). Furthermore, the two GISTs had different mutations in the c-kit gene, suggesting that they were derived from different clonal origins...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29410603/the-expression-of-mdm2-in-gastrointestinal-stromal-tumors-immunohistochemical-analysis-of-35-cases
#16
Boubacar Efared, Gabrielle Atsame-Ebang, Layla Tahiri, Ibrahim Sory Sidibé, Fatimazahra Erregad, Nawal Hammas, Samia Arifi, Ihsane Mellouki, Abdelmalek Ousadden, Khalid Mazaz, Hinde El Fatemi, Laila Chbani
Background: Gastrointestinal stromal tumors (GIST) are the most common primary mesenchymal tumors of the digestive system. The assessment of their biological behavior still remains a scientific challenge. To date, there are no well-established biological prognostic markers of GIST. Our aim is to study the expression of the MDM2 oncoprotein in GIST through an immunohistochemical analysis. Methods: It was a retrospective study of 35 cases of GIST diagnosed from 2009 to 2012 in the department of pathology of Hassan II university hospital, Fès, Morocco...
2018: BMC Clinical Pathology
https://www.readbyqxmd.com/read/29394813/-a-long-term-survivor-who-are-responding-to-sunitinib-treatment-for-recurrent-imatinib-resistant-gastrointestinal-stromal-tumor-gist-of-the-stomach
#17
Kazuki Kano, Haruhiko Cho, Yukio Maezawa, Toru Aoyama, Tsutomu Hayashi, Takanobu Yamada, Tsutomu Sato, Takashi Oshima, Norio Yukawa, Yasushi Rino, Munetaka Masuda, Takashi Ogata, Takaki Yoshikawa
A 63-year-old man underwent a laparoscopic partial gastrectomy for GIST on September, 2001. Three years and 2 months after the gastrectomy, an abdominal CT showed multiple recurrences in S5 and S6 in the liver and peritoneum. After 4 months from the start of imatinib treatment(400mg/day), peritoneal tumors disappeared and the patient maintained stable disease by imatinib treatment for 8 years. However, on December, 2012, an abdominal CT scan revealed the regrowth of the tumor in S6 in the liver, and PET-CT showed focal progression of only the S6 lesion...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394755/-radical-resection-of-huge-gastrointestinal-stromal-tumor-of-the-stomach-following-neoadjuvant-chemotherapy-with-lmatinib-acase-report
#18
Yoko Hiraki, Hiroaki Kato, Osamu Shiraishi, Yumiko Tanaka, Mitsuru Iwama, Atsushi Yasuda, Masayuki Shinkai, Yutaka Kimura, Motohiro Imano, Haruhiko Imamoto, Takushi Yasuda
The usefulness and safety of imatinibfor neoadjuvant chemotherapy for resectable gastrointestinal stromal tumor(GIST) has not been established. We reported a case of a huge GIST of the stomach that was safely resected following preoperative imatinibtherapy. A 69-year-old man was hospitalized with abdominal fullness which increased rapidly from a month ago. A CT scan showed a huge tumor containing solid and cystic component which was accompanied by an extra-wall nodule. The tumor was strongly suspected to be originated from the stomach and EUS-FNA revealed GIST...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394616/-laparoscopic-local-resection-for-a-gastric-gist-with-ulcer-locating-near-to-the-esophagogastric-junction-a-case-report
#19
Yoshihiro Tanaka, Toshiyuki Kosuga, Shuhei Komatsu, Kazuma Okamoto, Katsutoshi Shoda, Tomohiro Arita, Hirotaka Konishi, Ryo Morimura, Yasutoshi Murayama, Atsushi Shiozaki, Yoshiaki Kuriu, Hisashi Ikoma, Masayoshi Nakanishi, Hitoshi Fujiwara, Eigo Otsuji
A 39-year-old woman visited our hospital because of epigastric pain. Gastrointestinal endoscopy revealed a gastric submucosal tumor, 30mm in size, with ulcer locating near to the esophagogastric junction, and it was diagnosed with GIST by the endoscopic ultrasonography-guided fine needle aspiration. Then, she underwent laparoscopic surgery for the removal of gastric GIST. After peeling around the upper stomach, the local resection of the stomach was performed with linear staplers in the minor axis direction under the vision of the endoscope and laparoscope...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29382014/calcifying-fibrous-tumor-of-stomach-a-case-report
#20
Bo-Jing Li, Xiao-Dan Yang, Wei-Xiang Chen, Yi-Hai Shi, Zhi-Hong Nie, Jian Wu
RATIONALE: Calcifying fibrous tumor (CFT) is a rare benign soft tissue mesenchymal neoplasm. Although the gastrointestinal (GI) tract is the most common predilection site of CFT, the clinicians, even including pathologist, generally consider it as GI stromal tumor (GIST) or other submucosal tumors such as schwannoma and leiomyoma. PATIENT CONCERNS: A 55-year-old man presented with complaints of epigastric discomfort and abdominal distention for more than 1 year...
November 2017: Medicine (Baltimore)
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