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Gastric GIST

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https://www.readbyqxmd.com/read/29215507/robotic-gastrotomy-with-intracorporeal-suture-for-patients-with-gastric-gastrointestinal-stromal-tumors-located-at-cardia-and-subcardiac-region
#1
Jian Zhao, Gang Wang, Zhiwei Jiang, Chuanwei Jiang, Jiang Liu, Jiahui Zhou, Jieshou Li
PURPOSE: Few studies of robotic gastric gastrointestinal stromal tumors (GISTs) resection have been conducted. This study was aimed to evaluate the robotic gastrotomy with intracorporeal suture for patients with GISTs located at cardia and subcardiac region. MATERIALS AND METHODS: From January 2014 to August 2016, 11 patients with GISTs located at cardia and subcardiac region underwent robotic gastrotomy with intracorporeal suture. Data of these patients were collected...
December 6, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29207963/two-staging-systems-for-gastrointestinal-stromal-tumors-in-the-stomach-which-is-better
#2
Chul Hong Park, Gwang Ha Kim, Bong Eun Lee, Geun Am Song, Do Youn Park, Kyung Un Choi, Dae Hwan Kim, Tae Yong Jeon
BACKGROUND: The prognosis of a gastrointestinal stromal tumor (GIST) is influenced by its anatomic site; however, few studies on the prognosis of gastric GISTs have been reported. The aims of this study were to evaluate long-term prognoses of patients who underwent surgical resection for gastric GISTs and to compare the clinical efficacy of two staging systems: the National Institutes of Health (NIH) consensus criteria and the 7th Union for International Cancer Control/American Joint Committee on Cancer (UICC/AJCC) tumor-node-metastasis (TNM) staging system...
December 6, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29203825/adjuvant-imatinib-for-patients-with-high-risk-gastrointestinal-stromal-tumors-a-retrospective-cohort-study
#3
Rui Zhao, Yong Wang, Yuqian Huang, Yaping Cui, Lin Xia, Yi Chen, Wen Zhuang, Yong Zhou, Xiaoting Wu
The duration of adjuvant imatinib for high-risk patients with gastrointestinal stromal tumors (GISTs) is still controversial. Therefore, we retrospectively analyzed the data of high-risk patients with GISTs to investigate the appropriate duration. All 185 patients were divided into 4 groups: <1 year (Group A), 1-2 years (Group B), 2-3 years (Group C) and >3 years (Group D). The mean recurrence-free survival (RFS) in Groups A, B, and C were 44.3, 62.1, and 86.8 months, respectively (P < 0.001); the mean overall survival (OS) in Groups A, B and C was 75...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29200317/pediatric-gist-presenting-as-anemia
#4
Paola Cianci, Chiara Luini, Maddalena Marinoni, Luigi Nespoli, Alessandro Salvatoni, Silvia Salvatore
Gastrointestinal stromal tumors (GIST) are tumors of the gastrointestinal (GI) tract originating from the myenteric ganglion cells (interstitial cells of Cajal), that are very rare in children and adolescents. The most common clinical manifestation is acute or chronic, overt or occult GI bleeding although these tumors are asymptomatic in 10-30% of patients. We report a case of gastric GIST in a 11-year-old girl presenting with an iron deficiency refractory anemia without gastrointestinal symptoms and stool evidence of GI bleeding that caused a slight diagnostic delay...
December 4, 2017: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29192406/gastric-gastrointestinal-stromal-tumors-gist-a-case-series-and-current-state-of-the-art-in-the-workup-and-treatment-of-this-rare-disease
#5
Neil R Sharma, Harishankar Gopakumar, Scott Harrison, Natalie Ehmke, Christina Zelt
No abstract text is available yet for this article.
December 1, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29167690/synchronous-gists-associated-with-multiple-sporadic-tumors-a-case-report
#6
Danila Comandini, Azzurra Damiani, Alessandro Pastorino
Gastrointestinal stromal tumors (GISTs) are rare neoplasms, but they also represent the most common mesenchymal tumors of the gastrointestinal tract originating from the cell of Cajal. GIST incidence ranges around 1% of all gastrointestinal malignancies. Approximately 5% of all GISTs have a hereditary etiology. The remaining 95% of GISTs are considered sporadic events, with up to 75% of cases driven by a constitutional activation of the c-KIT proto-oncogene. GISTs are generally solitary lesions. Nonetheless, multiple sporadic GISTs can occur and present as synchronous or metachronous tumors, usually associated with familial GIST...
2017: Drugs in Context
https://www.readbyqxmd.com/read/29152299/gastrointestinal-stromal-tumor-an-incidental-finding-during-laparoscopic-bariatric-surgery
#7
Shireesh Saurabh
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. Lack of clinical symptoms and findings on preoperative upper endoscopy makes its diagnosis difficult in bariatric patients. A laparoscopic resection of the gastric GIST during bariatric surgery is associated with good long-term prognosis.
November 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29151288/-the-value-of-18-f-fdg-pet-ct-imaging-in-predicting-the-malignant-potential-of-gist
#8
S X Li, M D Tang, D Y Lin, D J Liu, Q H Lyu, J P Zhang, Z H Cai
Objective: To evaluate the value of (18)F-FDG PET-CT in predicting the malignant potential of Gastrointestinal Stromal Tumors (GIST). Methods: The clinical and pathological features of 31 patients with GIST confirmed by surgery or biopsy were retrospectively analyzed. The malignant potential of GIST before treatment was assessed by (18)F-FDG PET-CT. The GIST risk classification was graded according to the Standard revised by the National Institutes of Health (NIH) in 2008. The relationship between the maximal standard uptake value (SUVmax) and GIST risk classification, tumor diameter, Ki-67 index, and mitotic count were analyzed respectively...
November 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29132401/meta-analysis-comparing-laparoscopic-versus-open-resection-for-gastric-gastrointestinal-stromal-tumors-larger-than-5%C3%A2-cm
#9
Xiao Lian, Fan Feng, Man Guo, Lei Cai, Zhen Liu, Shushang Liu, Shuao Xiao, Gaozan Zheng, Guanghui Xu, Hongwei Zhang
BACKGROUND: Data on the safety and feasibility of laparoscopic versus open resection for gastric gastrointestinal stromal tumors (GISTs) larger than 5 cm are limited. Therefore, the aim of this meta-analysis was to compared laparoscopic and open resection for gastric GISTs larger than 5 cm. METHODS: We perform a literature search on PubMed, the Cochrane Library, and Embase. Review Manage version 5.1 (RevMan 5.1) was used for data analysis. The GRADE profiler software (version 3...
November 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29115925/synchronous-occurrence-of-hereditary-gastric-adenocarcinoma-gastrointestinal-stromal-tumor-and-esophageal-small-cell-and-squamous-carcinoma-in-situ-an-extremely-rare-case-report
#10
Huijie Fan, Pei Lu, Li Xu, Yanru Qin, Jing Li
BACKGROUND: Hereditary diffuse gastric carcinoma (HDGC) accounts for 1-3% of all gastric carcinomas. Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the gastrointestinal (GI) tract but they comprise fewer than 1% of all GI malignancies. Small-cell carcinoma (SmCC) is a rare histological type of esophageal carcinoma, accounting for 0.4% to 2.8% of all esophageal tumors. Co-occurrence of SmCC with esophageal tumors caused by squamous carcinoma is also very uncommon...
November 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29113157/lack-of-microsatellite-instability-in-gastrointestinal-stromal-tumors
#11
Nathália C Campanella, Cristovam Scapulatempo-Neto, Lucas Faria Abrahão-Machado, Antônio Talvane Torres De Oliveira, Gustavo N Berardinelli, Denise Peixoto Guimarães, Rui M Reis
The microsatellite instability (MSI) phenotype may constitute an important biomarker for patient response to immunotherapy, particularly to anti-programmed death-1 inhibitors. MSI is a type of genomic instability caused by a defect in DNA mismatch repair (MMR) proteins, which is present mainly in colorectal cancer and its hereditary form, hereditary nonpolyposis colorectal cancer. Gastrointestinal stromal tumor (GIST) development is associated with activating mutations of KIT proto-oncogene receptor tyrosine kinase (KIT) or platelet-derived growth factor receptor α (PDGFRA), which are oncogenes that predict the response to imatinib mesylate...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29093627/oval-mucosal-opening-bloc-biopsy-after-incision-and-widening-by-ring-thread-traction-for-submucosal-tumor
#12
Hirohito Mori, Hideki Kobara, Yu Guan, Yasuhiro Goda, Nobuya Kobayashi, Noriko Nishiyama, Tsutomu Masaki
Gastric submucosal tumors (SMTs) less than 2 cm are generally considered benign neoplasms, and endoscopic observation is recommended, but SMTs over 2 cm, 40% of which are gastrointestinal stromal tumors (GISTs), have malignant potential. Although the Japanese Guidelines for GIST recommend partial surgical resection for GIST over 2 cm with malignant potential as well as en bloc large tissue sample to obtain appropriate and large specimens of SMTs, several reports have been published on tissue sampling of SMTs, such as with endoscopic ultrasound sound fine needle aspiration, submucosal tunneling bloc biopsy, and the combination of bite biopsy and endoscopic mucosal resection...
October 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29083255/comparison-analysis-of-three-different-types-of-minimally-invasive-procedures-for-gastrointestinal-stromal-tumors-%C3%A2-5%C3%A2-cm
#13
Xiaonan Yin, Yuan Yin, Huijiao Chen, Chaoyong Shen, Sumin Tang, Zhaolun Cai, Bo Zhang, Zhixin Chen
OBJECTIVE: This study aimed to evaluate the safety, feasibility, and prognosis of three different types of minimally invasive procedures for treating gastric gastrointestinal stromal tumors (GISTs) ≤5 cm. MATERIALS AND METHODS: The clinical data, perioperative conditions, and the follow-up results of patients who underwent laparoscopic resection (LAP), laparoscopic and endoscopic cooperative surgery (LECS), or endoscopic submucosal dissection (ESD) for gastric GISTs ≤5 cm were retrospectively collected and analyzed...
October 30, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29078625/laparoscopic-techniques-and-strategies-for-gastrointestinal-gists
#14
REVIEW
Chang Min Lee, Sungsoo Park
The laparoscopic approach is widely accepted surgical treatment for gastrointestinal submucosal tumors (SMTs). In this chapter, we will introduce laparoscopic techniques and strategy for gastrointestinal SMTs, in accordance with those for gastrointestinal stromal tumors (GISTs). The indication for a laparoscopic approach has been related to tumor size. The upper limit of tumor size has increased, according to recent trends, and there is no established guideline for a lower limit. All patients undergoing laparoscopic surgery receive preoperative examinations including gastrofiberscopy, upper gastrointestinal radiography, computed tomography (CT), and endoscopic ultrasonography (EUS)...
2017: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29075963/endoscopic-evaluation-and-management-of-gastric-stromal-tumors
#15
REVIEW
Kambiz Kadkhodayan, Ehsan Rafiq, Robert H Hawes
Purpose of Review Gastrointestinal stromal tumors (GISTs) are both relatively common. Management of these lesions has been challenging with emerging interest in the endoscopic approach for both diagnostic and therapeutic interventions. Recent Findings Although these can be visualized on CT scan, endoscopic ultrasound (EUS) represents the standard method of evaluation and characterization using fine needle aspiration cytology (FNA) when indicated. While EUS-FNA can yield diagnostic cells, full characterization requires a sufficient volume of viable cells to do molecular analysis for c-KIT and determine the mitotic index...
December 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29062458/bariatric-surgery-and-incidental-gastrointestinal-stromal-tumors-a-single-center-study-vsj-competition-1-st-place
#16
Maciej Walędziak, Anna Różańska-Walędziak, Piotr K Kowalewski, Michał R Janik, Jakub Brągoszewski, Krzysztof Paśnik
INTRODUCTION: Gastrointestinal stromal tumors (GISTs), originating from Cajal cells, are most commonly located in the stomach; therefore they can be found in the specimens excised during bariatric operations. The global prevalence of GISTs is about 130 cases per million population. Morbidity differs depending on geographical latitude. Although surgery is the treatment of choice for GISTs, 40-50% of patients after radical surgical treatment will have a relapse or metastases. AIM: To analyze the incidence of GISTs in patients undergoing bariatric surgery and to verify whether an operation performed according to the bariatric protocol is oncologically radical in case of GIST...
September 2017: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/29058376/prognostic-role-of-tumor-necrosis-in-patients-undergoing-curative-resection-for-gastric-gastrointestinal-stromal-tumor-a-multicenter-analysis-of-740-cases-in-china
#17
Xuechao Liu, Haibo Qiu, Peng Zhang, Xingyu Feng, Tao Chen, Yong Li, Kaixiong Tao, Guoxin Li, Xiaowei Sun, Zhiwei Zhou
Tumor necrosis is associated with poor clinical outcomes in many malignancies. We aimed to determine whether tumor necrosis was an independent predictor of outcomes in gastric gastrointestinal stromal tumors (GISTs). We retrospectively analyzed data from 740 patients undergoing curative resection for gastric GIST at four centers between 2001 and 2015. Disease-free survival (DFS) was estimated with the Kaplan-Meier method, and associations with prognosis were assessed with Cox regression models. Tumor necrosis was present in 122 cases (16...
October 23, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29018259/clinicopathological-and-molecular-characteristics-of-synchronous-gastric-adenocarcinoma-and-gastrointestinal-stromal-tumors
#18
Jun-Ming Luo, Fa-Long Cao, Chen Meng, Li-Jun Lin, Si-Qing Ma, Shao-Hua Peng, Hong-Ling Gao, Sara Javidiparsijani, Gui-Rong Wang, Meng-Lan Zhang, Jian-Guo Xin, Yi-Chun Wang, Shu-Kun Zhang
Synchronous gastric tumors that consist of both gastrointestinal stromal tumor (GIST) and adenocarcinoma are rare. We studied the clinicopathological and molecular characteristics of six cases containing both gastric adenocarcinoma and GIST. By means of immunohistochemical analysis, all GIST cells expressed CD117, CD34 and Dog1 in all six synchronous gastric adenocarcinomas with GIST, and in GIST alone. Sequencing analysis demonstrated that exon 11 c-kit mutations were present in two of six synchronous tumors and four of five GISTs...
October 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28969200/gastroduodenal-intussusception-due-to-gastrointestinal-stromal-tumour-gist
#19
Abdul Rehman Abdul Jameel, Durairaj Segamalai, Gnanasekaran Murugaiyan, Rajendran Shanmugasundaram, Naganath Babu Obla
Gastroduodenal intussusception is the rarest forms of adult intussusception. We present a case of gastroduodenal intussusception due to a gastric Gastrointestinal Stromal Tumour (GIST). The patient was a 65-year-old female who clinically presented as acute gastric outlet obstruction. The patient was managed by gentle reduction of the intussusception, followed by wedge resection of the tumour. She was relieved of her symptoms and recurrence free for past one year.
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28953190/laparoscopic-surgery-for-large-gastric-submucosal-tumors
#20
Kodai Takahashi, Eiji Kanehira, Aya Kamei, Takashi Tanida, Kazunori Sasaki
BACKGROUND: In general, laparoscopic resection for gastric gastrointestinal stromal tumors (GISTs) >5 cm is not recommended. However, there is a lack of evidence to support this recommendation. PATIENTS AND METHODS: This study included 108 patients who underwent laparoscopic surgery for gastric GISTs. Of the 108 patients, 23 had GISTs>5 cm. The aim of this study is to evaluate the oncological safety of laparoscopic surgery for large gastric GISTs. In addition, we performed a rapid systematic review of laparoscopic surgery for large gastric GISTs...
September 25, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
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