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Gastric GIST

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https://www.readbyqxmd.com/read/29650923/-a-case-of-gastric-gist-with-pathological-complete-response-achieved-by-long-term-chemotherapy-with-imatinib-mesylate
#1
Junya Kondo, Hikari Chijimatsu, Taiki Kijima, Yukiko Nagashima, Hideto Hayashi, Katsuhiko Morita, Kouichiro Sakata, Mihoko Setoguchi
A 78-year-old woman was diagnosed with a gastrointestinal stromal tumor(GIST)of the stomach, gradually increasing from 5 years prior. The tumor was suspected to invade the pancreatic body tail and spleen, as observed with computed tomography. Because the patient refused to undergo resection, we administered imatinib mesylate for 6 years. Since early rectal cancer was revealed, the patient was referred for resection and underwent laparoscopic low anterior resection and partial gastrectomy. Histopathologically, the tumor was replaced by tissues with myxomatous changes, and no viable tumor cells were detected...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29643676/discordant-primary-resistance-to-imatinib-mesylate-in-the-same-individual-and-splenic-involvement-in-recurring-gastric-gastrointestinal-stromal-tumors-assessment-by-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#2
Preeti Fargose, Sandip Basu
Discordant primary resistance and response of the metastatic lesions in the same individual coupled with splenic involvement in gastrointestinal stromal tumors (GISTs) are relatively uncommon. We herein report such a case of recurring GIST of the stomach that presented with the involvement of spleen with 18 F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) imaging documentation. Ultrasonography-guided fine needle aspiration cytology from the splenic and paravesical lesions demonstrated metastatic spindle cell tumor consistent with diagnosis of metastasis from GIST of the stomach...
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29629225/igg4-related-disease-in-the-stomach-which-was-confused-with-gastrointestinal-stromal-tumor-gist-two-case-reports-and-review-of-the-literature
#3
Ho Seok Seo, Yoon Ju Jung, Cho Hyun Park, Kyo Young Song, Eun Sun Jung
Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated fibro-inflammatory disorder characterized by specific pathological findings and elevated serum IgG4 level. IgG4-RD in the stomach is rare, and occasionally diagnosed as gastric subepithelial tumor (SET) by endoscopy or computed tomography scan. Two female patients in the age group of 40-50 years were diagnosed with 4 cm sized gastric SET. One underwent laparoscopic gastric wedge resection. Another one had a history of subtotal gastrectomy for early gastric cancer and idiopathic thrombocytopenic purpura with oral steroids administration...
March 2018: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29595183/gastrointestinal-stromal-tumours-of-stomach-robot-assisted-excision-with-the-da-vinci-surgical-system-regardless-of-size-and-location-site
#4
Niccolo Furbetta, Matteo Palmeri, Simone Guadagni, Gregorio Di Franco, Desirée Gianardi, Saverio Latteri, Emanuele Marciano, Andrea Moglia, Alfred Cuschieri, Giulio Di Candio, Franco Mosca, Luca Morelli
AIMS: The role of minimally invasive surgery of gastrointestinal stromal tumours (GISTs) of the stomach remains uncertain especially for large and/or difficult located tumours. We are hereby presenting a single-centre series of robot-assisted resections using the da Vinci Surgical System (Si or Xi). SUBJECTS AND METHODS: Data of patients undergoing robot-assisted treatment of gastric GIST were retrieved from the prospectively collected institutional database and a retrospective analysis was performed...
March 23, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29575341/coexistence-of-gastrointestinal-stromal-tumor-and-leiomyosarcoma-of-the-stomach-presenting-as-a-collision-tumor-a-case-report-and-review-of-literature
#5
Hiroki Kitagawa, Mayumi Kaneko, Mikihiro Kano, Yuta Ibuki, Vishwa Jeet Amatya, Yukio Takeshima, Naoki Hirabayashi, Seiichi Hirota
Collision tumor of the stomach is rare. We report a rare case of a gastric collision tumor consisting of gastrointestinal stromal tumors (GISTs) and leiomyosarcoma (LMS). Computed tomography scan revealed a 15 cm sized mass in the posterior wall of the body of the stomach. Gross examination of the wedge resection specimen showed the tumor located in the muscularis propria with extramural protrusion into the peritoneal cavity and the gastric cavity with geographic necrosis, hemorrhage, and mucosal ulceration...
March 25, 2018: Pathology International
https://www.readbyqxmd.com/read/29552662/asian-consensus-guidelines-for-gastrointestinal-stromal-tumor-what-is-the-same-and-what-is-different-from-global-guidelines
#6
REVIEW
Toshirou Nishida
There are some disparities between the clinical practice and profiles of cancer in Asia and those in Europe & North America. In Asia, surgical oncologists still have a major role in the multidisciplinary therapy of gastrointestinal stromal tumor (GIST), whereas medical oncologists hold this status in the West. Although the incidence of clinical GIST is considered similar between the two areas, small gastric GISTs are more frequently treated by surgery in East Asia compared with Europe & North America...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29530096/laparoscopic-and-endoscopic-cooperative-surgery-for-intra-mucosal-gastric-carcinoma-adjacent-to-the-ulcer-scars
#7
Masahiko Aoki, Satoshi Tokioka, Ken Narabayashi, Akitoshi Hakoda, Yosuke Inoue, Naoki Yorifuji, Yoshihide Chino, Isao Sato, Yutaro Egashira, Toshihisa Takeuchi, Kazuhide Higuchi
BACKGROUND: Laparoscopic and endoscopic cooperative surgery (LECS) was performed for the local resection of gastrointestinal stromal tumors (GIST). LECS enables less resection of the lesion area and preserves function. Furthermore, LECS can be safely performed and independent of tumor location. However, LECS is not usually used for cases involving gastric carcinoma because it may seed tumor cells into the peritoneal cavity when the gastric wall is perforated. Here, we report seven cases of LECS for intra-mucosal gastric carcinoma, which were difficult to carry out by endoscopic submucosal dissection (ESD) because of ulcer scars...
March 12, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29487722/prognostic-role-of-the-primary-tumour-site-in-patients-with-operable-small-intestine-and-gastrointestinal-stromal-tumours-a-large-population-based-analysis
#8
Hua Ye, Hua Xin, Qi Zheng, Qijun Shen, Wenyu Dai, Feng Wu, Cheng Zheng, Ping Chen
The postoperative recurrence risk of gastrointestinal stromal tumour (GIST) should be estimated when considering adjuvant systemic therapy. Previous studies in the literature have suggested that small intestinal GISTs are more aggressive than gastric GISTs. We assessed the prognostic role of the primary tumour site in patients with operable GIST to compare the outcomes of gastric and small intestinal GISTs over a decade of treatment. The Surveillance, Epidemiology, and End Results (SEER) database was queried for cases of gastric and small intestinal GISTs between 2004 and 2014 using the GIST-specific histology code (ICD-O-3 code 8936), and only patients with tissues sampled by surgical resection were selected for this study...
January 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29486293/familial-pdgfra-mutation-syndrome-somatic-and-gastrointestinal-phenotype
#9
Paul N Manley, Suzan Abu-Abed, Richard Kirsch, Andrea Hawrysh, Nicole Perrier, Harriet Feilotter, Aaron Pollett, Robert Riddell, Lawrence Hookey, Jagdeep S Walia
Germline activating platelet derived growth factor receptor alpha (PDGFRA) mutations have been described in four families. All the index patients have presented with multiple mesenchymal tumors of the gastrointestinal tract. We identified a fifth family with four first-degree relatives that harbor a PDGFRA exon 18 (D846V) germline mutation. The affected kindred have a unique phenotype including coarse facies and skin, broad hands and feet, and previously undescribed premature tooth loss. While the index patient presented with multiple small bowel inflammatory fibroid polyps (IFPs) and has a gastric gastrointestinal stromal tumor (GIST), no tumors have yet been identified in other family members...
February 24, 2018: Human Pathology
https://www.readbyqxmd.com/read/29451912/expression-of-cell-cycle-regulators-and-frequency-of-tp53-mutations-in-high-risk-gastrointestinal-stromal-tumors-prior-to-adjuvant-imatinib-treatment
#10
Michaela Angelika Ihle, Sebastian Huss, Wiebke Jeske, Wolfgang Hartmann, Sabine Merkelbach-Bruse, Hans-Ulrich Schildhaus, Reinhard Büttner, Harri Sihto, Kirsten Sundby Hall, Mikael Eriksson, Peter Reichardt, Heikki Joensuu, Eva Wardelmann
Despite of multitude investigations no reliable prognostic immunohistochemical biomarkers in GIST have been established so far with added value to predict the recurrence risk of high risk GIST besides mitotic count, primary location and size. In this study, we analyzed the prognostic relevance of eight cell cycle and apoptosis modulators and of TP53 mutations for prognosis in GIST with high risk of recurrence prior to adjuvant treatment with imatinib. In total, 400 patients with high risk for GIST recurrence were randomly assigned for adjuvant imatinib either for one or for three years following laparotomy...
2018: PloS One
https://www.readbyqxmd.com/read/29435684/recurrence-free-survival-after-resection-of-gastric-gastrointestinal-stromal-tumors-classified-according-to-a-strict-definition-of-tumor-rupture-a-population-based-study
#11
Toto Hølmebakk, Ivar Hompland, Bodil Bjerkehagen, Stephan Stoldt, Øyvind Sverre Bruland, Kirsten Sundby Hall, Kjetil Boye
BACKGROUND: In gastrointestinal stromal tumors (GISTs), rupture is a high-risk feature and an indication for adjuvant treatment; however, the independent impact of rupture on prognosis is uncertain and the term is inconsistently defined. In the present study, a previously proposed definition of 'tumor rupture' was applied on a population-based cohort of gastric GISTs. METHODS: Patients undergoing surgery for non-metastatic gastric GISTs from 2000 to 2015 were identified in the regional sarcoma database of Oslo University Hospital...
February 12, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29394616/-laparoscopic-local-resection-for-a-gastric-gist-with-ulcer-locating-near-to-the-esophagogastric-junction-a-case-report
#12
Yoshihiro Tanaka, Toshiyuki Kosuga, Shuhei Komatsu, Kazuma Okamoto, Katsutoshi Shoda, Tomohiro Arita, Hirotaka Konishi, Ryo Morimura, Yasutoshi Murayama, Atsushi Shiozaki, Yoshiaki Kuriu, Hisashi Ikoma, Masayoshi Nakanishi, Hitoshi Fujiwara, Eigo Otsuji
A 39-year-old woman visited our hospital because of epigastric pain. Gastrointestinal endoscopy revealed a gastric submucosal tumor, 30mm in size, with ulcer locating near to the esophagogastric junction, and it was diagnosed with GIST by the endoscopic ultrasonography-guided fine needle aspiration. Then, she underwent laparoscopic surgery for the removal of gastric GIST. After peeling around the upper stomach, the local resection of the stomach was performed with linear staplers in the minor axis direction under the vision of the endoscope and laparoscope...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29382014/calcifying-fibrous-tumor-of-stomach-a-case-report
#13
Bo-Jing Li, Xiao-Dan Yang, Wei-Xiang Chen, Yi-Hai Shi, Zhi-Hong Nie, Jian Wu
RATIONALE: Calcifying fibrous tumor (CFT) is a rare benign soft tissue mesenchymal neoplasm. Although the gastrointestinal (GI) tract is the most common predilection site of CFT, the clinicians, even including pathologist, generally consider it as GI stromal tumor (GIST) or other submucosal tumors such as schwannoma and leiomyoma. PATIENT CONCERNS: A 55-year-old man presented with complaints of epigastric discomfort and abdominal distention for more than 1 year...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29375748/comparison-between-laparoscopic-and-open-surgery-for-large-gastrointestinal-stromal-tumors-a-meta-analysis
#14
Jian-Xin Cui, Yun-He Gao, Hong-Qing Xi, Ai-Zhen Cai, Ke-Cheng Zhang, Ji-Yang Li, Bo Wei, Lin Chen
AIM: To investigate whether laparoscopic surgery is as safe and feasible as open resection for patients with larger gastrointestinal stromal tumors (GISTs) (≥ 5 cm). METHODS: A systematic search of PubMed, EMBASE, Web of Science and the Cochrane Library database was performed. Relevant studies of laparoscopic and open surgery for GISTs of > 5 cm published before December 2016 were identified from these databases. The quality of the studies was assessed by the Newcastle-Ottawa Quality Assessment Scale...
January 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29346826/gastroduodenal-intussusception-and-pylorus-obstruction-induced-by-a-c-kit-negative-gastric-gastrointestinal-stromal-tumor-case-report-and-review-of-the-literature
#15
Yong Zhou, Xu-Dong Wu, Quan Shi, Chuan-Hai Xu, Jing Jia
INTRODUCTION:  Gastrointestinal stromal tumors (GISTs) are infrequently reported to cause gastroduodenal intussusception, especially in the cases with complete pylorus obstruction. GISTs comprise only 1 - 3 % of all gastrointestinal tract tumors, and most of them strongly express the c-KIT protein. Approximately 5 % of GISTs show negative staining of c-KIT. CASE PRESENTATION:  A 69-year-old man complained of acute abdominal pain accompanied with nausea and vomiting for 6 hours...
April 2018: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29341147/genotype-and-risk-of-tumour-rupture-in-gastrointestinal-stromal-tumour
#16
K Boye, J-M Berner, I Hompland, Ø S Bruland, S Stoldt, K Sundby Hall, B Bjerkehagen, T Hølmebakk
BACKGROUND: Tumour rupture is a strong predictor of poor outcome in gastrointestinal stromal tumours (GISTs) of the stomach and small intestine. The objective was to determine whether tumour genotype was associated with risk of rupture. METHODS: Rupture was classified according to the definition proposed by the Oslo Sarcoma Group. Since January 2000, data were registered retrospectively for all patients at Oslo University Hospital undergoing surgery for localized GIST of the stomach or small intestine...
January 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29318911/comparison-of-three-prognostic-models-for-predicting-cancer-specific-survival-among-patients-with-gastrointestinal-stromal-tumors
#17
Hani Oweira, Jan Schmidt, Arianeb Mehrabi, Hasan Kulaksiz, Paul Schneider, Othmar Schöb, Anwar Giryes, Omar Abdel-Rahman
AIM: To evaluate the predictive value for cancer-specific survival of the models of the American Joint Committee on Cancer (AJCC) stage, NIH and Armed Forces Institute of Pathology (AFIP) among patients with gastrointestinal stromal tumors (GISTs). METHODS: Surveillance, Epidemiology and End Results database (2010-2014) was accessed. Overall survival analysis and adjusted cancer-specific Cox regression hazard was calculated. RESULTS: For gastric GISTs, concordance-index according to AJCC was 0...
February 2018: Future Oncology
https://www.readbyqxmd.com/read/29313287/primary-gastric-synovial-sarcoma-mimicking-a-gastrointestinal-stromal-tumor-gist-gastric-synovial-sarcoma
#18
Griffin Olsen, Eliza W Beal, Sheryl Pfeil, Mary Dillhoff
No abstract text is available yet for this article.
January 8, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29278883/microrna-152-inhibits-tumor-cell-growth-while-inducing-apoptosis-via-the-transcriptional-repression-of-cathepsin-l-in-gastrointestinal-stromal-tumor
#19
Hong-Jie Lu, Jing Yan, Pei-Ying Jin, Gui-Hong Zheng, Su-Ming Qin, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
OBJECTIVE: MicroRNAs are widely thought to play a regulatory role in gene expression. Although the more unique microRNA expression profiles have been reported in several tumors, there remains a scarcity of knowledge in relation to microRNA expression profiles in GISTs. During this study, through the alteration in the expression of microRNA-152 (miR-152) in gastrointestinal stromal tumor (GIST) cells, we subsequently evaluated its ability to influence the processes associated with cancer, including proliferation, migration, invasion, and apoptosis, as well as the associated mechanisms...
February 14, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29275234/a-case-of-gastric-glomus-tumor-resection-using-laparoscopy-endoscopy-cooperative-surgery-lecs
#20
Taro Aoba, Takehito Kato, Kazuhiro Hiramatsu, Yoshihisa Shibata, Motoi Yoshihara, Naoya Yamaguchi, Tadahiro Kamiya
INTRODUCTION: Gastric glomus tumors are rare submucosal mesenchymal tumors. Because gastric glomus tumors are submucosal tumors and resemble gastrointestinal stromal tumors (GISTs), preoperative diagnosis is difficult. We present a case of gastric glomus tumor that was removed by laparoscopy endoscopy cooperative surgery (LECS). CASE PRESENTATION: A 67-year-old female was taken to the emergency room at our hospital due to epigastric pain. An upper gastrointestinal endoscopy revealed a submucosal tumor (SMT) located in the lesser curvature of the upper body of the stomach...
2018: International Journal of Surgery Case Reports
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