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Gastric GIST

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https://www.readbyqxmd.com/read/29018259/clinicopathological-and-molecular-characteristics-of-synchronous-gastric-adenocarcinoma-and-gastrointestinal-stromal-tumors
#1
Jun-Ming Luo, Fa-Long Cao, Chen Meng, Li-Jun Lin, Si-Qing Ma, Shao-Hua Peng, Hong-Ling Gao, Sara Javidiparsijani, Gui-Rong Wang, Meng-Lan Zhang, Jian-Guo Xin, Yi-Chun Wang, Shu-Kun Zhang
Synchronous gastric tumors that consist of both gastrointestinal stromal tumor (GIST) and adenocarcinoma are rare. We studied the clinicopathological and molecular characteristics of six cases containing both gastric adenocarcinoma and GIST. By means of immunohistochemical analysis, all GIST cells expressed CD117, CD34 and Dog1 in all six synchronous gastric adenocarcinomas with GIST, and in GIST alone. Sequencing analysis demonstrated that exon 11 c-kit mutations were present in two of six synchronous tumors and four of five GISTs...
October 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28969200/gastroduodenal-intussusception-due-to-gastrointestinal-stromal-tumour-gist
#2
Abdul Rehman Abdul Jameel, Durairaj Segamalai, Gnanasekaran Murugaiyan, Rajendran Shanmugasundaram, Naganath Babu Obla
Gastroduodenal intussusception is the rarest forms of adult intussusception. We present a case of gastroduodenal intussusception due to a gastric Gastrointestinal Stromal Tumour (GIST). The patient was a 65-year-old female who clinically presented as acute gastric outlet obstruction. The patient was managed by gentle reduction of the intussusception, followed by wedge resection of the tumour. She was relieved of her symptoms and recurrence free for past one year.
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28953190/laparoscopic-surgery-for-large-gastric-submucosal-tumors
#3
Kodai Takahashi, Eiji Kanehira, Aya Kamei, Takashi Tanida, Kazunori Sasaki
BACKGROUND: In general, laparoscopic resection for gastric gastrointestinal stromal tumors (GISTs) >5 cm is not recommended. However, there is a lack of evidence to support this recommendation. PATIENTS AND METHODS: This study included 108 patients who underwent laparoscopic surgery for gastric GISTs. Of the 108 patients, 23 had GISTs>5 cm. The aim of this study is to evaluate the oncological safety of laparoscopic surgery for large gastric GISTs. In addition, we performed a rapid systematic review of laparoscopic surgery for large gastric GISTs...
September 25, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28933252/laparoscopic-versus-open-resection-of-gastric-gastrointestinal-stromal-tumors-larger-than-5-cm-a-single-center-retrospective-study
#4
Guanglin Qiu, Jing Wang, Xiangming Che, Shicai He, Chao Wei, Xuqi Li, Ke Pang, Lin Fan
BACKGROUND: The technical feasibility and oncological safety of laparoscopic surgery for gastric gastrointestinal stromal tumors (GISTs) larger than 5 cm has not been adequately studied. Therefore, we performed this retrospective study to investigate the clinical outcomes of gastric GIST patients treated with laparoscopic surgery compared with those who underwent open surgery. METHODS: We retrospectively evaluated the outcomes of 48 consecutive patients who underwent gastric resection for gastric GISTs larger than 5 cm...
September 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/28931294/-carney-triad
#5
L Fiala, I Kocáková, R Šimůnek, E Krejčí, I Babánková, R Šefr
Carney triad is a synchronous or metachronous association of gastric gastrointestinal stromal tumors (GIST), pulmonary chondroma and extra-adrenal paraganglioma. The majority of patients have only one or two components of the triad, all three tumors being found in only about 2% of the patients at the time of the first diagnosis. The most common combination is gastric and pulmonary tumors. We report a case of Carney triad which was diagnosed at Masaryk Memorial Cancer Institute. A 57-year-old female patient with a history of gastric resection for leiomyosarcoma at the age of 14 and with an unclear pulmonary lesion evident on chest X-ray since as early as 2003...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/28916847/endoscopic-resection-of-gastric-gastrointestinal-stromal-tumors-originating-from-the-muscularis-propria-layer-in-north-america-methods-and-feasibility-data
#6
Iman Andalib, Daniel Yeoun, Ramesh Reddy, Steve Xie, Shahzad Iqbal
INTRODUCTION: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. In recent years, endoscopic procedures such as endoscopic enucleation (EN) and endoscopic full-thickness resection (EFTR) have been used to resect GISTs. This study aimed to investigate the clinical efficacy, safety, and feasibility of endoscopic resection of GISTs in a North American population. METHODS: A total of 25 patients with gastric submucosal lesions (SML) underwent endoscopic resection from December 2014 to April 2016...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28900994/-analysis-of-gastric-gastrointestinal-stromal-tumors-in-shandong-province-a-midterm-report-of-multicenter-gissg1201-study
#7
Qingsheng Hou, Wenqiang Luo, Leping Li, Yong Dai, Lixin Jiang, Ailiang Wang, Xianqun Chu, Yuming Li, Daogui Yang, Chunlei Lu, Linguo Yao, Gang Cui, Huizhong Lin, Gang Chen, Qing Cui, Huanhu Zhang, Zengjun Lun, Lijian Xia, Yingfeng Su, Guoxin Han, Xizeng Hui, Zhixin Wei, Zuocheng Sun, Hongliang Guo, Yanbing Zhou
OBJECTIVE: To summarize the treatment status of gastric gastrointestinal stromal tumor (GIST) in Shandong province,by analyzing the clinicopathological features and prognostic factors. METHODS: Clinicopathological and follow-up data of 1 165 patients with gastric GIST between January 2000 and December 2013 from 23 tertiary referral hospitals in Shandong Province were collected to establish a database. The risk stratification of all cases was performed according to the National Institutes of Health(NIH) criteria proposed in 2008...
September 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28877809/a-review-of-sleeve-gastrectomy-specimen-histopathology
#8
Luke A Kinsinger, James C Garber, Oliver Whipple
With the increasing popularity of sleeve gastrectomy, many stomach specimens are being evaluated. Understanding the significance and treatment for unexpected pathology is important. This study examines the incidence of relevant histopathology of sleeve gastrectomy specimens. It evaluates previous data for each histopathology and provides recommendations for treatment. In this study, a retrospective review was performed for 241 patients who underwent sleeve gastrectomy from 2009 to 2014 at a single institution...
November 1, 2016: American Surgeon
https://www.readbyqxmd.com/read/28825569/-laparoscopic-atypical-gastrectomy-in-the-treatment-of-gastric-gist-short-term-and-medium-term-outcomes
#9
Santiago Reimondez, Federico Moser, Pablo S Maldonado, Álvaro Alcaraz, Alejandro M Rossini, Lucio R Obeide
Gastrointestinal stromal tumors are the most common mesenchymal neoplasms of the gastrointestinal tract. Recently, many studies have addressed the laparoscopic management of these tumors. The aim of this study was to evaluate the safety and efficacy of laparoscopic atypical gastrectomy in the resolution of these neoplasms. In the period between January 2009 and December 2015, 24 patients with suspected gastric GIST less than 5 cm in size underwent surgery under this approach. Abscense of peritoneal and liver metastases and immunohistochemistry expression of CD117 antigen were considered as inclusion criteria...
2017: Medicina
https://www.readbyqxmd.com/read/28808875/ssat-state-of-the-art-conference-current-surgical-management-of-gastric-tumors
#10
Jeffrey A Norton, Teresa Kim, Joseph Kim, Martin D McCarter, Kaitlyn J Kelly, Joyce Wong, Jason K Sicklick
INTRODUCTION: The current era of gastric surgery is marked by low morbidity and mortality rates, innovative strategies to approach resections with a minimally invasive fashion or hyperthermic intraperitoneal chemotherapy (HIPEC), as well as improved understanding of the biology of sporadic and hereditary stromal, neuroendocrine, and epithelial malignancies. METHODS: In 2017, the Society for Surgery of the Alimentary Tract convened a State-of-the-Art Conference on Current Surgical Management of Gastric Tumors with both international experts and emerging leaders in the field of gastric surgery...
August 14, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28799152/-gastric-schwannoma-rare-differenzial-diagnosis-of-acute-upper-gastrointestinal-gi-bleeding
#11
Orestis Lyros, Stephan Schickel, Katrin Schierle, Albrecht Hoffmeister, Ines Gockel
Schwannomas are benign tumors derived from Schwann cells and their typical site of origin is the subcutaneous tissue of the extremities. Gastrointestinal localization of Schwannomas is extremely rare and the stomach is the prevalent site. Gastric schwannomas primarily occur in the gastric submucosa and are usually asymptomatic.We present a rare case of a solitary gastric schwannoma in a 51-year old male, which initially manifested with hematemesis by acute upper gastrointestinal (GI) bleeding. The upper GI-Endoscopy revealed a gastric submucosal tumor, 7 cm in size, located in the proximal corpus and fundus...
August 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28798000/epidemiology-and-survival-analysis-of-gastrointestinal-stromal-tumors-in-lebanon-real-life-study-from-a-hospital-tumor-registry-2000-2015
#12
Elie El Rassy, Fadi Nasr, Tarek Assi, Toni Ibrahim, Nathalie Rassy, Joseph Bou Jaoude, Marcel Massoud, Georges Chahine
BACKGROUND: We report, to our knowledge, one of the largest studies concerning gastrointestinal stromal tumors (GIST) in the Middle East. We also present a survival analysis of GIST in our 15-year real-life experience. METHODS: We studied demographic, epidemiologic and survival characteristics of 70 patients with confirmed GIST in a cross-sectional study between 2000 and 2015. RESULTS: The median age of our patients was 62 ±12.8 years (range, 25-84) with a male to female ratio of 1...
May 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28796048/clinicopathologic-study-of-succinate-dehydrogenase-deficient-gastrointestinal-stromal-tumors-a-single-institutional-experience-in-china
#13
Weizhen Liu, Xiangyu Zeng, Xiuli Wu, Jun He, Jinbo Gao, Xiaoming Shuai, Guobin Wang, Peng Zhang, Kaixiong Tao
Gastrointestinal stromal tumors (GISTs) that are not driven by kinase mutations, as are most GISTs, often show loss of function of the succinate dehydrogenase (SDH) complex and are considered SDH-deficient GISTs. SDH-deficient GISTs share many distinct characteristics compared with conventional GISTs. However, data regarding these characteristics, particularly among Asian people, are relatively limited. The objective of this study was to characterize the clinicopathologic characteristics, treatment, and prognosis of these uncommon GISTs...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28783738/improvement-to-ultrasonographical-differential-diagnosis-of-gastric-lesions-the-value-of-contrast-enhanced-sonography-with-gastric-distention
#14
Tingting Li, Man Lu, Jun Song, Ping Wu, Xueqing Cheng, Zhenqi Zhang
OBJECTIVE: The purpose of this retrospective study is to evaluate the diagnostic value of contrast enhanced sonography plus gastric distention sonography, the Double Contrast-enhanced Ultrasound (DCUS) in gastric lesions. METHODS: 107 cases with pathology confirmed gastric lesions were retrospectively reviewed, DCUS and oral contrast agent ultrasound (US) were performed in all cases prior to operation. Perfusion parameters including arrival time (AT), peak intensity (PI), time to peak (TTP), and area under the curve (AUC) of the lesion and surrounding normal tissue were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28756979/thymosin-beta-4-overexpression-correlates-with-high-risk-groups-in-gastric-gastrointestinal-stromal-tumors-a-retrospective-analysis-by-immunohistochemistry
#15
Sevinç Şahin, Ozgur Ekinci, Selda Seçkin, Ayse Dursun
BACKGROUND: Thymosin beta-4 (Tβ4) is a protein that is linked to a number of important biological actions and recently tumor progression and poor prognosis of some tumors. The aim of this study was to evaluate Tβ4 expression in gastric GISTs and correlate with some clinicopathological characteristics related with prognosis and clinical outcome in order to add further data to the current literature. METHODS: Tβ4 antibody was applied to the 4μm-thick paraffin sections of 57 gastric GISTs by immunohistochemistry...
July 6, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28754403/-clinical-and-pathological-features-of-gastrointestinal-stromal-tumors-gist-in-a-single-institution-a-descriptive-study-and-review-of-the-literature
#16
Diego Flores-Funes, Ramón José Lirón-Ruiz, Carmen Victoria Pérez-Guarinos, Juan Gervasio Martín-Lorenzo, José Antonio Torralba-Martínez, Alberto Giménez-Bascuñana, María Asunción Chaves-Benito, José Luis Aguayo-Albasini
INTRODUCTION: This study was aimed to assess the main clinical, pathological and therapeutic characteristics of a cohort of gastrointestinal stromal tumors (GIST). METHODS: Observational study including 66 patients diagnosed with GIST admitted to our hospital between 2002 and 2015. Parameters related to medical history, clinical manifestations, medical and surgical treatment, histopathology, and morbi-mortality were studied. A review of the literature was included to correlate with the results...
August 2017: Cirugía Española
https://www.readbyqxmd.com/read/28744850/the-expression-of-hematopoietic-progenitor-cell-antigen-cd34-is-regulated-by-dna-methylation-in-a-site-dependent-manner-in-gastrointestinal-stromal-tumours
#17
Irina Bure, Alexander Braun, Claudia Kayser, Helene Geddert, Inga-Marie Schaefer, Silke Cameron, Michael B Ghadimi, Philipp Ströbel, Martin Werner, Arndt Hartmann, Stefan Wiemann, Abbas Agaimy, Florian Haller, Evgeny A Moskalev
The anatomic site-dependent expression of hematopoietic progenitor cell antigen CD34 is a feature of gastrointestinal stromal tumours (GISTs). The basis for the differential CD34 expression is only incompletely understood. This study aimed at understanding the regulation of CD34 in GISTs and clarification of its site-dependent expression. Two sample sets of primary GISTs were interrogated including 52 fresh-frozen and 134 paraffin-embedded and formalin-fixed specimens. DNA methylation analysis was performed by HumanMethylation450 BeadChip array in three cell lines derived from gastric and intestinal GISTs, and differentially methylated CpG sites were established upstream of CD34...
July 26, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28740967/incidental-gastrointestinal-stromal-tumor-at-a-gastroscopic-polypectomy-specimen-a-case-report-and-review-of-literature
#18
Dursun Özgür Karakaş, Özgür Dandin, Ahmet Ziya Balta, Yavuz Özdemir, İsmail Yılmaz, İlker Sücüllü
Although gastrointestinal stromal tumors (GISTs) comprise less than 1% of all gastrointestinal (GI) tract tumors, they are the most common mesenchymal tumors of the GI tract. Gastrointestinal stromal tumors can occur anywhere along the GI tract, but the stomach and small intestine are the most frequently involved sites. Gastrointestinal stromal tumors are frequently asymptomatic, and one-third of all cases are found incidentally. Endoscopy, endoscopic ultrasonography, and computed tomography are useful tools in the diagnosis...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28739378/succinate-dehydrogenase-sdh-deficiency-carney-triad-and-the-epigenome
#19
REVIEW
Nikolaos Settas, Fabio R Faucz, Constantine A Stratakis
In this report, we review the relationship between succinate dehydrogenase (SDH) deficiency and the epigenome, especially with regards to two clinical conditions. Carney triad (CT) is a very rare disease with synchronous or metachronous occurrence of at least three different tumor entities; gastric gastrointestinal stromal tumor (GIST), paraganglioma (PGL), and pulmonary chondroma. This condition affects mostly females and it is never inherited. Another disease that shares two of the tumor components of CT, namely GIST and PGL is the Carney-Stratakis syndrome (CSS) or dyad...
July 21, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28738922/laparoscopic-trans-gastric-endoscopic-removal-of-gastroesophageal-junction-gastrointestinal-stromal-tumors-gist
#20
Aaron Lee Wiegmann, Brett A Fair, Jonathan A Myers
No abstract text is available yet for this article.
July 1, 2017: American Surgeon
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