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Gastric GIST

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https://www.readbyqxmd.com/read/29876697/totally-laparoscopic-transluminal-resection-for-gastrointestinal-stromal-tumors-located-at-the-cardiac-region
#1
Zejian Lyu, Zifeng Yang, Junjiang Wang, Weixian Hu, Yong Li
BACKGROUND: The most common laparoscopic surgery for gastric gastrointestinal stromal tumors (GISTs) currently includes laparoscopic wedge resection, laparoscopic transgastric surgery, and laparoscopic intragastic surgery [Ohashi in Surg Endosc 9:169-171, 1995]. METHODS: The clinical data of 10 cases of cardiac endophytic GIST patients who received total laparoscopic intragastric surgery from June 2014 to March 2016 in Guangdong General Hospital were retrospectively analyzed...
June 6, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29862096/gastric-glomus-tumor-an-uncommon-source-for-an-acute-upper-gi-bleed
#2
Douglas Morte, Jason Bingham, Vance Sohn
Background: Glomus tumors are uncommon mesenchymal neoplasms originating from modified smooth muscle cells in the glomus body. They are generally small, solitary lesions found in the distal extremities. Rarely, involvement in the abdominal viscera can occur. In such cases, hematemesis/melena and epigastric discomfort are the most common initial symptoms. Although gastric glomus tumors can demonstrate malignant behavior, criteria for identifying malignant potential have yet to be established...
2018: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/29848836/combination-of-arginine-glutamine-and-omega-3-fatty-acid-supplements-for-perioperative-enteral-nutrition-in-surgical-patients-with-gastric-adenocarcinoma-or-gastrointestinal-stromal-tumor-gist-a-prospective-randomized-double-blind-study
#3
C Ma, H Tsai, W Su, L Sun, Y Shih, J Wang
Background: Perioperative enteral nutrition (EN) enriched with immune-modulating substrates is preferable for patients undergoing major abdominal cancer surgery. In this study, perioperative EN enriched with immune-modulating nutrients such as arginine, glutamine, and omega-3 fatty acids was evaluated for its anti-inflammatory efficacy in patients with gastric adenocarcinoma or gastrointestinal stromal tumor (GIST) receiving curative surgery. Materials and Methods: This prospective, randomized, double-blind study recruited 34 patients with gastric adenocarcinoma or gastric GIST undergoing elective curative surgery...
May 31, 2018: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/29764388/clinicopathological-features-surgical-strategy-and-prognosis-of-duodenal-gastrointestinal-stromal-tumors-a-series-of-300-patients
#4
Zhen Liu, Gaozan Zheng, Jinqiang Liu, Shushang Liu, Guanghui Xu, Qiao Wang, Man Guo, Xiao Lian, Hongwei Zhang, Fan Feng
BACKGROUND: The relatively low incidence of duodenal gastrointestinal stromal tumors (GISTs) and the unique anatomy make the surgical management and outcomes of this kind of tumor still under debate. Thus, this study aimed to explore the optimal surgical strategy and prognosis of duodenal GISTs. METHODS: A total of 300 cases of duodenal GISTs were obtained from our center (37 cases) and from case reports or series (263 cases) extracted from MEDLINE. Clinicopathological features, type of resections and survivals of duodenal GISTs were analyzed...
May 15, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29755776/gastrointestinal-stromal-tumors-in-the-imatinib-era-15-years-experience-of-a-tertiary-center
#5
Armando Peixoto, Pedro Costa-Moreira, Marco Silva, Ana Luísa Santos, Susana Lopes, Filipe Vilas-Boas, Pedro Moutinho-Ribeiro, Guilherme Macedo
Gastrointestinal stromal tumors (GISTs) were associated with a disease free survival rate of disease of 50% at 5 years, but the actual natural history since the advent of imatinib is poorly described. Our objective was to evaluate the evolution in the treatment and prognosis of patients with GISTs since the start of imatinib. Retrospective analysis of GISTs diagnosed between January 2000 and June 2015 in a Portuguese large volume center. We included 131 patients, 55% female, with a mean age of 64±14 years, followed for a median of 30 months; 64% of cases had gastric involvement; 92% of the tumors were c-Kit positive; 95% of patients were operated...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755761/distinctive-features-of-gastrointestinal-stromal-tumors-arising-from-the-colon-and-rectum
#6
Rebecca Zhu, Fangfang Liu, Gabriella Grisotti, Javier Pérez-Irizarry, Charles H Cha, Caroline H Johnson, Daniel J Boffa, Dale Han, Kimberly L Johung, Yawei Zhang, Sajid A Khan
Background: Colon and rectal gastrointestinal stromal tumors (GISTs) are rare and poorly characterized. Because the majority of treatment guidelines for GISTs are extrapolated from tumors of gastric and small bowel origin, our aim was to better characterize the unique clinicopathologic features and prognostic factors of colon and rectal GISTs to guide clinical care. Methods: The National Cancer Data Base (NCDB) was queried from 2006 to 2013 for cases of GISTs in the stomach, colon, and rectum...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29682624/non-exposed-endoscopic-wall-inversion-surgery-for-gastrointestinal-stromal-tumor
#7
Takashi Mitsui, Hiroharu Yamashita, Susumu Aikou, Keiko Niimi, Mitsuhiro Fujishiro, Yasuyuki Seto
Laparoscopic and endoscopic cooperative surgery (LECS) is an accepted method of laparoscopic wedge resection, which is minimally invasive, for gastrointestinal stromal tumors (GISTs). We established a type of LECS achieving a full-thickness resection, non-exposed endoscopic wall-inversion surgery (NEWS), in an effort to prevent exposure of the peritoneal cavity to gastric intraluminal contents. We employed this surgical technique in 28 gastric GIST patients. We failed to complete NEWS in the initial two patients and in one patient with a large tumor (40 mm × 35 mm), but otherwise carried out the procedure successfully...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29682464/gastric-inflammatory-fibroid-polyp-tumor-with-acute-intestinal-obstruction-vanek-s-tumor-can-mimick-a-giant-gastrointestinal-stromal-tumor-or-a-gastric-lymphoma
#8
Francesco Fleres, Carmelo Mazzeo, Antonio Ieni, Maurizio Rossitto, Eugenio Cucinotta
An inflammatory fibroid polyp (IFP) is a solitary rare benign neoplasm of the gastrointestinal tract, frequently located in the gastric antrum. IFPs account for about 0.1% of all gastric polyps. We report a case of a giant gastric inflammatory polyp of 2.5 cm × 7 cm that determines a gastric outlet obstruction called "ball valve syndrome" mimicking a gastrointestinal stromal tumor (GIST) and a gastric lymphoma, with an intestinal obstruction of high origin. Therefore, due to acute presentation we have decided to submit the patient to a subtotal gastrectomy...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29681019/high-percentage-pathological-findings-in-obese-patients-suggest-that-esophago-gastro-duodenoscopy-should-be-made-mandatory-prior-to-bariatric-surgery
#9
Mizelle D'Silva, Aparna Govil Bhasker, Nimisha S Kantharia, Muffazal Lakdawala
ᅟ: Obesity is a global epidemic and will soon become the number one priority in healthcare management. Bariatric surgery causes a significant improvement in obesity and its related complications. Pre-operative esophago-gastro-duodenoscopy (EGD) is done by several bariatric surgical teams across the world but is still not mandatory. AIM: To study the percentage of symptomatic and asymptomatic pathological EGD findings in obese patients undergoing bariatric surgery and to analyze whether these findings influence the eventual choice of bariatric surgery...
April 21, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29650923/-a-case-of-gastric-gist-with-pathological-complete-response-achieved-by-long-term-chemotherapy-with-imatinib-mesylate
#10
Junya Kondo, Hikari Chijimatsu, Taiki Kijima, Yukiko Nagashima, Hideto Hayashi, Katsuhiko Morita, Kouichiro Sakata, Mihoko Setoguchi
A 78-year-old woman was diagnosed with a gastrointestinal stromal tumor(GIST)of the stomach, gradually increasing from 5 years prior. The tumor was suspected to invade the pancreatic body tail and spleen, as observed with computed tomography. Because the patient refused to undergo resection, we administered imatinib mesylate for 6 years. Since early rectal cancer was revealed, the patient was referred for resection and underwent laparoscopic low anterior resection and partial gastrectomy. Histopathologically, the tumor was replaced by tissues with myxomatous changes, and no viable tumor cells were detected...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29643676/discordant-primary-resistance-to-imatinib-mesylate-in-the-same-individual-and-splenic-involvement-in-recurring-gastric-gastrointestinal-stromal-tumors-assessment-by-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#11
Preeti Fargose, Sandip Basu
Discordant primary resistance and response of the metastatic lesions in the same individual coupled with splenic involvement in gastrointestinal stromal tumors (GISTs) are relatively uncommon. We herein report such a case of recurring GIST of the stomach that presented with the involvement of spleen with 18 F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) imaging documentation. Ultrasonography-guided fine needle aspiration cytology from the splenic and paravesical lesions demonstrated metastatic spindle cell tumor consistent with diagnosis of metastasis from GIST of the stomach...
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29629225/igg4-related-disease-in-the-stomach-which-was-confused-with-gastrointestinal-stromal-tumor-gist-two-case-reports-and-review-of-the-literature
#12
Ho Seok Seo, Yoon Ju Jung, Cho Hyun Park, Kyo Young Song, Eun Sun Jung
Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated fibro-inflammatory disorder characterized by specific pathological findings and elevated serum IgG4 level. IgG4-RD in the stomach is rare, and occasionally diagnosed as gastric subepithelial tumor (SET) by endoscopy or computed tomography scan. Two female patients in the age group of 40-50 years were diagnosed with 4 cm sized gastric SET. One underwent laparoscopic gastric wedge resection. Another one had a history of subtotal gastrectomy for early gastric cancer and idiopathic thrombocytopenic purpura with oral steroids administration...
March 2018: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29595183/gastrointestinal-stromal-tumours-of-stomach-robot-assisted-excision-with-the-da-vinci-surgical-system-regardless-of-size-and-location-site
#13
Niccolo Furbetta, Matteo Palmeri, Simone Guadagni, Gregorio Di Franco, Desirée Gianardi, Saverio Latteri, Emanuele Marciano, Andrea Moglia, Alfred Cuschieri, Giulio Di Candio, Franco Mosca, Luca Morelli
AIMS: The role of minimally invasive surgery of gastrointestinal stromal tumours (GISTs) of the stomach remains uncertain especially for large and/or difficult located tumours. We are hereby presenting a single-centre series of robot-assisted resections using the da Vinci Surgical System (Si or Xi). SUBJECTS AND METHODS: Data of patients undergoing robot-assisted treatment of gastric GIST were retrieved from the prospectively collected institutional database and a retrospective analysis was performed...
March 23, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29575341/coexistence-of-gastrointestinal-stromal-tumor-and-leiomyosarcoma-of-the-stomach-presenting-as-a-collision-tumor-a-case-report-and-review-of-literature
#14
Hiroki Kitagawa, Mayumi Kaneko, Mikihiro Kano, Yuta Ibuki, Vishwa Jeet Amatya, Yukio Takeshima, Naoki Hirabayashi, Seiichi Hirota
Collision tumor of the stomach is rare. We report a rare case of a gastric collision tumor consisting of gastrointestinal stromal tumors (GISTs) and leiomyosarcoma (LMS). Computed tomography scan revealed a 15 cm sized mass in the posterior wall of the body of the stomach. Gross examination of the wedge resection specimen showed the tumor located in the muscularis propria with extramural protrusion into the peritoneal cavity and the gastric cavity with geographic necrosis, hemorrhage, and mucosal ulceration...
May 2018: Pathology International
https://www.readbyqxmd.com/read/29552662/asian-consensus-guidelines-for-gastrointestinal-stromal-tumor-what-is-the-same-and-what-is-different-from-global-guidelines
#15
REVIEW
Toshirou Nishida
There are some disparities between the clinical practice and profiles of cancer in Asia and those in Europe & North America. In Asia, surgical oncologists still have a major role in the multidisciplinary therapy of gastrointestinal stromal tumor (GIST), whereas medical oncologists hold this status in the West. Although the incidence of clinical GIST is considered similar between the two areas, small gastric GISTs are more frequently treated by surgery in East Asia compared with Europe & North America...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29530096/laparoscopic-and-endoscopic-cooperative-surgery-for-intra-mucosal-gastric-carcinoma-adjacent-to-the-ulcer-scars
#16
Masahiko Aoki, Satoshi Tokioka, Ken Narabayashi, Akitoshi Hakoda, Yosuke Inoue, Naoki Yorifuji, Yoshihide Chino, Isao Sato, Yutaro Egashira, Toshihisa Takeuchi, Kazuhide Higuchi
BACKGROUND: Laparoscopic and endoscopic cooperative surgery (LECS) was performed for the local resection of gastrointestinal stromal tumors (GIST). LECS enables less resection of the lesion area and preserves function. Furthermore, LECS can be safely performed and independent of tumor location. However, LECS is not usually used for cases involving gastric carcinoma because it may seed tumor cells into the peritoneal cavity when the gastric wall is perforated. Here, we report seven cases of LECS for intra-mucosal gastric carcinoma, which were difficult to carry out by endoscopic submucosal dissection (ESD) because of ulcer scars...
March 12, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29487722/prognostic-role-of-the-primary-tumour-site-in-patients-with-operable-small-intestine-and-gastrointestinal-stromal-tumours-a-large-population-based-analysis
#17
Hua Ye, Hua Xin, Qi Zheng, Qijun Shen, Wenyu Dai, Feng Wu, Cheng Zheng, Ping Chen
The postoperative recurrence risk of gastrointestinal stromal tumour (GIST) should be estimated when considering adjuvant systemic therapy. Previous studies in the literature have suggested that small intestinal GISTs are more aggressive than gastric GISTs. We assessed the prognostic role of the primary tumour site in patients with operable GIST to compare the outcomes of gastric and small intestinal GISTs over a decade of treatment. The Surveillance, Epidemiology, and End Results (SEER) database was queried for cases of gastric and small intestinal GISTs between 2004 and 2014 using the GIST-specific histology code (ICD-O-3 code 8936), and only patients with tissues sampled by surgical resection were selected for this study...
January 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29486293/familial-pdgfra-mutation-syndrome-somatic-and-gastrointestinal-phenotype
#18
Paul N Manley, Suzan Abu-Abed, Richard Kirsch, Andrea Hawrysh, Nicole Perrier, Harriet Feilotter, Aaron Pollett, Robert Riddell, Lawrence Hookey, Jagdeep S Walia
Germline activating platelet derived growth factor receptor alpha (PDGFRA) mutations have been described in four families. All the index patients have presented with multiple mesenchymal tumors of the gastrointestinal tract. We identified a fifth family with four first-degree relatives that harbor a PDGFRA exon 18 (D846V) germline mutation. The affected kindred have a unique phenotype including coarse facies and skin, broad hands and feet, and previously undescribed premature tooth loss. While the index patient presented with multiple small bowel inflammatory fibroid polyps (IFPs) and has a gastric gastrointestinal stromal tumor (GIST), no tumors have yet been identified in other family members...
February 24, 2018: Human Pathology
https://www.readbyqxmd.com/read/29451912/expression-of-cell-cycle-regulators-and-frequency-of-tp53-mutations-in-high-risk-gastrointestinal-stromal-tumors-prior-to-adjuvant-imatinib-treatment
#19
Michaela Angelika Ihle, Sebastian Huss, Wiebke Jeske, Wolfgang Hartmann, Sabine Merkelbach-Bruse, Hans-Ulrich Schildhaus, Reinhard Büttner, Harri Sihto, Kirsten Sundby Hall, Mikael Eriksson, Peter Reichardt, Heikki Joensuu, Eva Wardelmann
Despite of multitude investigations no reliable prognostic immunohistochemical biomarkers in GIST have been established so far with added value to predict the recurrence risk of high risk GIST besides mitotic count, primary location and size. In this study, we analyzed the prognostic relevance of eight cell cycle and apoptosis modulators and of TP53 mutations for prognosis in GIST with high risk of recurrence prior to adjuvant treatment with imatinib. In total, 400 patients with high risk for GIST recurrence were randomly assigned for adjuvant imatinib either for one or for three years following laparotomy...
2018: PloS One
https://www.readbyqxmd.com/read/29435684/recurrence-free-survival-after-resection-of-gastric-gastrointestinal-stromal-tumors-classified-according-to-a-strict-definition-of-tumor-rupture-a-population-based-study
#20
Toto Hølmebakk, Ivar Hompland, Bodil Bjerkehagen, Stephan Stoldt, Øyvind Sverre Bruland, Kirsten Sundby Hall, Kjetil Boye
BACKGROUND: In gastrointestinal stromal tumors (GISTs), rupture is a high-risk feature and an indication for adjuvant treatment; however, the independent impact of rupture on prognosis is uncertain and the term is inconsistently defined. In the present study, a previously proposed definition of 'tumor rupture' was applied on a population-based cohort of gastric GISTs. METHODS: Patients undergoing surgery for non-metastatic gastric GISTs from 2000 to 2015 were identified in the regional sarcoma database of Oslo University Hospital...
May 2018: Annals of Surgical Oncology
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