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Early stomach cancer

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https://www.readbyqxmd.com/read/29130978/peritoneal-seeding-after-gastric-perforation-during-endoscopic-submucosal-dissection-for-gastric-cancer
#1
Motohiro Hirao, Takuya Yamada, Tomoki Michida, Kazuhiro Nishikawa, Takuya Hamakawa, Eiji Mita, Masayuki Mano, Mitsugu Sekimoto
BACKGROUND/AIMS: Since the risk of cancer cells seeding the peritoneum after perforation during endoscopic submucosal dissection (ESD) is unclear, we retrospectively examined peritoneal relapse after gastric perforation during ESD for gastric cancer at a single institution. METHODS: Of 876 patients who underwent ESD for early gastric cancer between January 2002 and December 2015, 22 patients (2.5%) experienced gastric perforation during ESD at the Osaka National Hospital in Osaka, Japan...
November 8, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/29076479/-laparoscopic-and-robot-assisted-surgery-for-locally-advanced-and-generalized-stomach-cancer
#2
A F Chernousov, T V Khorobrykh, F P Vetshev, N M Abdulkhakimov, S V Osminin, A V Dulova
AIM: To analyze the first experience of laparoscopic and robot-assisted surgery for locally advanced and generalized stomach cancer at the Burdenko Clinic of Faculty Surgery. MATERIAL AND METHODS: Since 2011 27 laparoscopic and 2 robot-assisted operations for locally advanced and generalized stomach cancer have been performed in our hospital. Mean age of patients was 62.1±10 years. There were 19 men and 10 women. RESULTS: There were 11 gastrectomies with abdominal esophageal resection and 18 Billroth I subtotal resections...
2017: Khirurgiia
https://www.readbyqxmd.com/read/29067944/stomach-resection-with-intraoperative-fluoroscopy-in-laparoscopic-distal-gastrectomy-for-early-gastric-cancer
#3
Jun Kawachi, Hiroyuki Kashiwagi, Hidemitsu Ogino, Naoko Isogai, Rai Shimoyama, Ryuta Fukai, Katsunori Miyake, Akiko Sasaki, Takahiro Terashima, Shinichi Teshima, Kazunao Watanabe
BACKGROUND: In Japan, laparoscopic distal gastrectomy (LDG) is common for early gastric cancer. Formerly, we used to verify the location of the marking clip to decide the proximal incisional line with our hand, through a small epigastric incision. In 2015, we introduced intracorporeal reconstruction and started to decide the incisional line using intraoperative fluoroscopy. Herein, we aimed to evaluate the efficacy and safety of intraoperative fluoroscopy in LDG. PATIENTS AND METHODS: A total of 19 patients were included in this retrospective observational study...
October 23, 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29067581/serial-intermediate-term-quality-of-life-comparison-after-endoscopic-submucosal-dissection-versus-surgery-in-early-gastric-cancer-patients
#4
Young-Il Kim, Young Ae Kim, Chan Gyoo Kim, Keun Won Ryu, Young-Woo Kim, Jin Ah Sim, Young Ho Yun, Il Ju Choi
BACKGROUND: Endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) is expected to provide better long-term health-related quality of life (HRQOL) by preserving the entire stomach. We aimed to compare serial changes in HRQOL characteristics between patients who underwent ESD versus surgery for EGC. METHODS: A gastric cancer patient cohort was prospectively enrolled from 2004 to 2007. HRQOL of 161 EGC patients was prospectively assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC-QLQ-C30) and the stomach cancer-specific module EORTC-QLQ-STO22 at baseline (i...
October 24, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29058068/clinical-outcomes-of-gastric-cancer-patients-who-underwent-proximal-or-total-gastrectomy-a-propensity-score-matched-analysis
#5
Yuki Ushimaru, Yoshiyuki Fujiwara, Yuji Shishido, Yoshitomo Yanagimoto, Jeong-Ho Moon, Keijiro Sugimura, Takeshi Omori, Hiroshi Miyata, Masahiko Yano
BACKGROUND: Total gastrectomy (TG) and proximal gastrectomy (PG) are used to treat upper-third early gastric cancer. To date, no consensus has been reached regarding which procedure should be selected. The aim of this study was to validate the usefulness of preserving the stomach in early upper-third gastric cancer. METHODS: Between 2004 and 2013, 201 patients underwent PG or TG at our institution for treatment of upper-third early gastric cancer. According to the defined inclusion and exclusion criteria, 192 cases were enrolled in this study...
October 20, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29034350/function-preserving-surgery-for-gastric-cancer-current-status-and-future-perspectives
#6
REVIEW
Souya Nunobe, Naoki Hiki
The number of early gastric cancer (EGC) cases has been increasing because of improved diagnostic procedures including endoscopy and screening systems. Therefore, function-preserving gastrectomy (FPG) for EGC with the expectation of better quality of life (QOL) after surgery may be increasingly utilized, due to its association with low rate of lymph node metastasis and excellent survival and the possibility of employing less invasive procedures such as laparoscopic gastrectomy in combination. Pylorus-preserving gastrectomy (PPG) with curative intent lymph node dissection is a representative FPG that has been used in EGC, and its superiorities, indications, limitations, and survival benefits have already been reported in several retrospective studies...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29021452/a-case-of-familial-adenomatous-polyposis-with-multiple-helicobacter-negative-early-gastric-cancers-treated-by-endoscopic-submucosal-dissection
#7
Katsuki Yaguchi, Makomo Makazu, Kingo Hirasawa, Makoto Sugimori, Ryosuke Kobayashi, Chiko Sato, Ryosuke Ikeda, Takehide Fukuchi, Yasuaki Ishii, Hiroaki Kaneko, Wataru Shibata, Shoji Yamanaka, Yoshiaki Inayama, Shin Maeda
Stomach cancer rarely develops in patients with familial adenomatous polyposis (FAP), and Helicobacter pylori infection may increase the risk of FAP-related gastric cancer. We describe the case of a 64-year-old woman who developed multiple synchronous early gastric cancers without H. pylori infection. Nine cancer lesions were successfully treated by endoscopic submucosal dissection. An immunohistochemical analysis revealed that the tumors were positive for MUC2, MUC6, and CDX2, but negative for MUC5AC, suggesting that the tumors were gastrointestinal mixed type...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28989999/gallstone-cholecystectomy-and-risk-of-gastric-cancer
#8
Sung Hwa Kang, Young Hoon Kim, Young Hoon Roh, Kwan Woo Kim, Chan Joong Choi, Min Chan Kim, Su Jin Kim, Hee Jin Kwon, Jin Han Cho, Jin Seok Jang, Jong Hun Lee
BACKGROUNDS/AIMS: The aim of this retrospective study is to compare stomach cancer incidence, characteristics between gallstones, cholecystectomy and control groups. It also aims to investigate key variables' potential effects on overall survival. METHODS: A total of 99 patients, diagnosed with stomach cancers between April 1994 and December 2015, were identified. We excluded stomach cancer patients, accrued during the first year of follow-up in both the gallstones and cholecystectomy groups, assuming that they missed cancers...
August 2017: Annals of Hepato-Biliary-Pancreatic Surgery
https://www.readbyqxmd.com/read/28989591/familial-colorectal-cancer-type-x-in-central-iran-a-new-clinicopathologic-description
#9
Mehrdad Zeinalian, Mahdi Hadian, Morteza Hashemzadeh-Chaleshtori, Rasoul Salehi, Mohammad Hassan Emami
Background: Familial colorectal cancer type X (FCCX) is a subtype of mismatch repair (MMR)-proficient colorectal cancerin which the patients are clinically at risk for Lynch syndrome (LS), a common hereditary cancer predisposing syndrome. In this study, we described a new clinicopathological feature of the condition in central Iran. Materials and Methods: We designed a descriptive, retrospective study to screenat-risk colorectal cancer (CRC) patients, using Amsterdam II criteria and Molecular analysis in Isfahan (central Iran) throughout 2000-2013 period...
July 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/28965110/clinicopathological-assessment-of-gastric-xanthoma-as-potential-predictive-marker-of-gastric-cancer
#10
Shinji Kitamura, Naoki Muguruma, Koichi Okamoto, Toshihito Tanahashi, Akira Fukuya, Kumiko Tanaka, Daisaku Fujimoto, Tetsuo Kimura, Hiroshi Miyamoto, Yoshimi Bando, Hisashi Takeuchi, Masako Shiba, Tetsuji Takayama
BACKGROUND/AIMS: Gastric xanthomas are frequently observed in the stomach as small yellowish plaques or nodules. A close relationship among Helicobacter pylori infection, atrophic gastritis, and xanthomas has been reported. We assessed the clinicopathological features of gastric cancer with or without xanthomas. METHODS: A total of 91 patients who were diagnosed as having early gastric cancer were enrolled. We evaluated the gastritis status using scores for gastritis and atrophy, positivity of H...
September 30, 2017: Digestion
https://www.readbyqxmd.com/read/28951462/multiscale-modeling-of-inflammation-induced-tumorigenesis-reveals-competing-oncogenic-and-onco-protective-roles-for-inflammation
#11
Yucheng Guo, Qing Nie, Adam L MacLean, Yanda Li, Jinzhi Lei, Shao Li
Chronic inflammation is a serious risk factor for cancer; however, the routes from inflammation to cancer are poorly understood. Based on the processes implicated by frequently mutated genes associated with inflammation and cancer in three organs (stomach, colon and liver) extracted from the GEO, TCGA and GO databases, we present a multiscale model of the long-term evolutionary dynamics leading from inflammation to tumorigenesis. The model incorporates crosstalk among interactions on several scales, including responses to DNA damage, gene mutation, cell cycle behavior, population dynamics, inflammation, and metabolism-immune balance...
September 26, 2017: Cancer Research
https://www.readbyqxmd.com/read/28934829/-laparoscopic-proximal-gastrectomy-as-a-surgical-treatment-for-upper-third-early-gastric-cancer
#12
REVIEW
Do Joong Park, Young Suk Park, Sang Hoon Ahn, Hyung Ho Kim
Recently, the incidence of upper third gastric cancer has increased, and with it the number of endoscopic submucosal dissection (ESD) procedures performed has been increasing. However, if ESD is not indicated or non-curable, surgical treatment may be necessary. In the case of lower third gastric cancer, it is possible to preserve the upper part of the stomach; however, in the case of upper third gastric cancer, total gastrectomy is still the standard treatment option, regardless of the stage. This is due to the complications associated with upper third gastric cancer, such as gastroesophageal reflux after proximal gastrectomy rather than oncologic problems...
September 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28931294/-carney-triad
#13
L Fiala, I Kocáková, R Šimůnek, E Krejčí, I Babánková, R Šefr
Carney triad is a synchronous or metachronous association of gastric gastrointestinal stromal tumors (GIST), pulmonary chondroma and extra-adrenal paraganglioma. The majority of patients have only one or two components of the triad, all three tumors being found in only about 2% of the patients at the time of the first diagnosis. The most common combination is gastric and pulmonary tumors. We report a case of Carney triad which was diagnosed at Masaryk Memorial Cancer Institute. A 57-year-old female patient with a history of gastric resection for leiomyosarcoma at the age of 14 and with an unclear pulmonary lesion evident on chest X-ray since as early as 2003...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/28922727/the-relevance-of-gastric-cancer-biomarkers-in-prognosis-and-pre-and-post-chemotherapy-in-clinical-practice
#14
REVIEW
Muhammad Abbas, Murad Habib, Muhammad Naveed, Kumaragurubaran Karthik, Kuldeep Dhama, Meiqi Shi, Chen Dingding
Gastric cancer (GC) is one among the major cancer types, causing human deaths and present noticeable heterogeneity. The incidences and mortality rates are higher in males in comparison to females with a male to female ratio of 2.3:1. A lot of studies have revealed out the molecular basis, pathogenesis, invasion and metastasis related findings of gastric stomach cancer. Present review encompasses the salient information on various biomarkers for the early diagnosis, treatment and prognosis of gastric cancer elaborate the clinical importance of serum tumor markers in patients with this cancer as well as checking the growths, together with epigenetic changes and genetic polymorphisms...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28911091/a-phase-iii-trial-comparing-oral-s-1-cisplatin-and-intravenous-5-fluorouracil-cisplatin-in-patients-with-untreated-diffuse-gastric-cancer
#15
J A Ajani, M Abramov, I Bondarenko, Y Shparyk, V Gorbunova, A Hontsa, N Otchenash, M Alsina, S Lazarev, J Feliu, A Elme, V Esko, K Abdalla, U Verma, F Benedetti, T Aoyama, H Mizuguchi, L Makris, G Rosati
Background: The effect of histology-based treatment regimen on diffuse gastric adenocarcinoma has not been evaluated in clinical trials. This international phase III trial evaluated the efficacy and safety of S-1 (a contemporary oral fluoropyrimidine)/cisplatin versus 5-fluorouracil (5-FU)/cisplatin in chemotherapy-naïve patients with diffuse-type adenocarcinoma involving the gastroesophageal junction or stomach. Patients and methods: Eligibility criteria included untreated, measurable, advanced diffuse adenocarcinoma confirmed by central pathology and performance status of 0-1...
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28890816/epidemiological-profile-of-gastric-cancer-in-the-northwestern-region-of-algeria-about-116-cases
#16
Safia Fehim, Racheda Bouhaous, Mustapha Diaf, Amine Mokhtar Drici, Meghit Boumediene Khaled
BACKGROUND: Gastric cancer (GC) remains a public health issue despite the global incidence decrease over the last decades. GC is the third leading cause of cancer-related death worldwide and stills of poor prognosis due to its late detection. The overall objective of our study was to describe the epidemiological, clinical, and histopathological aspects of stomach cancer. However, the specific purpose was to determine the gastric precancerous lesions among patients with histologically confirmed GC admitted at the gastroenterology department of the University Hospital of Sidi-Bel-Abbes city, Algeria...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28885329/simultaneous-endoscopic-submucosal-dissection-for-multiple-early-gastric-cancers-in-a-low-volume-center
#17
Zhao-Sheng Chen, Xi-Feng Jin, Hong-Lei Wu, Jian-Qiang Guo
The aim of the study is to evaluate the safety and efficacy of simultaneous endoscopic submucosal dissection (ESD) for multiple early gastric cancers.A total of 70 solitary early gastric cancers from 70 patients and 20 multiple early gastric cancers from 10 patients were included in this retrospective study. The curative resection rate, en bloc resection rate, procedure-related complications, and local recurrence were compared between the 2 groups.There was no statistical difference in the rate of complete resection, en bloc resection, and curative resection between the 2 groups (P > ...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28881882/long-term-functional-outcomes-after-replacement-of-the-esophagus-with-gastric-colonic-or-jejunal-conduits-a-systematic-literature-review
#18
T Irino, A Tsekrekos, A Coppola, C M Scandavini, A Shetye, L Lundell, I Rouvelas
It is generally recognized that in patients with an intact stomach diagnosed with esophageal cancer, gastric tubulization and pull-up shall always be the preferred technique for reconstruction after an esophageal resection. However, in cases with extensive gastroesophageal junction (GEJ) cancer with aboral spread and after previous gastric surgery, alternative methods for reconstruction have to be pursued. Moreover, in benign cases as well as in those with early neoplastic lesions of the esophagus and the GEJ that are associated with long survival, it is basically unclear which conduit should be recommended...
December 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28868113/gastric-xanthoma-is-a-predictive-marker-for-metachronous-and-synchronous-gastric-cancer
#19
Narihiro Shibukawa, Shohei Ouchi, Shuji Wakamatsu, Yuhei Wakahara, Akira Kaneko
AIM: To investigate predictive markers for metachronous and synchronous gastric cancer (GC), which can develop after endoscopic submucosal dissection (ESD). METHODS: A total of 352 patients underwent ESD for early GC at NTT West Osaka Hospital between June 2006 and February 2016. Exclusion criteria were as follows: Remnant stomach, unknown Helicobacter pylori status, and endoscopic observation of the whole stomach outside our hospital. We analyzed data from 192 patients comprising 109 patients with solitary GC (Group A) and 83 with metachronous and synchronous GC (Group B)...
August 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28860646/metaplasia-tissue-injury-adaptation-and-a-precursor-to-the-dysplasia-cancer-sequence
#20
REVIEW
Veronique Giroux, Anil K Rustgi
Metaplasia is the replacement of one differentiated somatic cell type with another differentiated somatic cell type in the same tissue. Typically, metaplasia is triggered by environmental stimuli, which may act in concert with the deleterious effects of microorganisms and inflammation. The cell of origin for intestinal metaplasia in the oesophagus and stomach and for pancreatic acinar-ductal metaplasia has been posited through genetic mouse models and lineage tracing but has not been identified in other types of metaplasia, such as squamous metaplasia...
October 2017: Nature Reviews. Cancer
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