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Early gastric cancer

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https://www.readbyqxmd.com/read/28629379/laparoscopic-gastrectomy-in-obese-gastric-cancer-patients-a-comparative-study-with-non-obese-patients-and-evaluation-of-difference-in-laparoscopic-methods
#1
Ke Chen, Yu Pan, Shu-Ting Zhai, Jia-Qin Cai, Qi-Long Chen, Ding-Wei Chen, Yi-Ping Zhu, Yu Zhang, Ya-Ping Zhang, Hendi Maher, Xian-Fa Wang
BACKGROUND: Obesity is a growing epidemic around the world, and obese patients are generally regarded as high risk for surgery compared with normal weight patients. The purpose of this study was to evaluate the influence of obesity on the surgical outcomes of laparoscopic gastrectomy (LG) for gastric cancer. METHODS: We reviewed data for all patients undergoing LG for gastric cancer at our institute between October 2004 and December 2016. Patients were divided into non-obese and obese groups and the perioperative outcomes were compared...
June 19, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28624843/expressions-of-ras-homolog-gene-family-member-a-rhoa-and-cyclooxygenase-2-cox-2-proteins-in-early-gastric-cancer-and-their-role-in-the-development-of-gastric-cancer
#2
Li Song, Yali Guo, Baohong Xu
BACKGROUND This research focused on detecting the expressions of RhoA and cyclooxygenase-2 (COX-2) proteins in early gastric cancer tissues and to explore their role in the development of gastric cancer. MATERIAL AND METHODS Surgically resected gastric cancer tissues and the paired normal paracancerous tissues were collected from 26 patients with early gastric cancer from January 2015 to November 2015. The expressions of RhoA and COX-2 proteins were detected by using RT-PCR and immunohistochemistry techniques, respectively...
June 18, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28621235/mmp-2-together-with-mmp-9-overexpression-correlated-with-lymph-node-metastasis-and-poor-prognosis-in-early-gastric-carcinoma
#3
Zhihua Yao, Tian Yuan, Haiying Wang, Shuna Yao, Yan Zhao, Ying Liu, Shuiling Jin, Junfeng Chu, Yuanlin Xu, Wenping Zhou, Shujun Yang, Yanyan Liu
The aim of this study was to correlate matrix metalloproteinase-2 and matrix metalloproteinase-9 expression with the clinicopathological features and outcome of patients with early gastric cancer and to clinically elucidate more information on the role of matrix metalloproteinase-2 and matrix metalloproteinase-9 protein overexpression with regard to lymph node metastasis of early gastric cancer. The levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 protein expression were assessed by immunohistochemistry...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28620624/early-gastric-cancer-associated-with-a-gastric-lipoma
#4
Ai Sato, Atsushi Irisawa, Goro Shibukawa, Akane Yamabe, Mariko Fujisawa, Noriyuki Arakawa, Yoshitsugu Yoshida
No abstract text is available yet for this article.
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28619681/gastric-carcinoma-after-sleeve-gastrectomy-for-obesity
#5
Miljana Vladimirov, Uwe Hesse, Hubert J Stein
Obesity is associated with an increased risk of cancer development in the upper gastrointestinal tract. We present the case of a female patient with gastric carcinoma after sleeve gastrectomy. Before bariatric surgery, one rationale for performing routine endoscopy is to detect clinically relevant conditions with the potential to change the surgical procedure. After bariatric surgery in symptomatic patients and in patients with unspecific symptoms, early upper endoscopy should be performed to detect potential carcinomas of the upper gastrointestinal tract...
April 25, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28616919/-effects-of-early-enteral-immunonutrition-on-postoperative-immune-function-and-rehabilitation-of-patients-with-gastric-cancer-and-nutritional-risk
#6
Chang-Bing Peng, Wen-Zhong Li, Rui Xu, Wen Zhuang
OBJECTIVES: To investigate the effects of early enteral immunonutrition on postoperative immune function and rehabilitation of gastric cancer patients with nutritional risk. METHODS: New hospitalized patients with gastric cancer were evaluated the nutrient status based on NRS 2002. The patients who scored between 3 to 5 points were randomized into two groups(30 cases for each group), and those in experimental group were given 7-d early postoperative enteral immune nutrition, those in control group were given normal nutrition...
May 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28616612/robotic-gastrectomy-for-gastric-cancer
#7
REVIEW
Masanori Tokunaga, Akio Kaito, Shizuki Sugita, Masahiro Watanabe, Hideki Sunagawa, Takahiro Kinoshita
The number of robotic gastrectomy (RG) performed per year has been increasing, particularly in East Asia where the incidence of gastric cancer is high and approximately half of the cases are diagnosed as early gastric cancer. With articulated devices of RG, surgeons are able to perform every procedure more meticulously, which can result in less bleeding and damage to organs. There are many single arm and comparative studies, and these study showed similar trends, which included relatively less estimated blood loss and longer operation time following RG than laparoscopic gastrectomy (LG), equivalent number of harvested lymph nodes and similar length of postoperative hospital stay between RG and LG...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28616610/current-approaches-to-gastric-cancer-in-peru-and-mexico
#8
REVIEW
Erlan Santos
In Peru, the incidence of gastric cancer is reported to be around 15.8 per 100,000 inhabitants and it is the second most common oncological disease in men and the third one in women. Additionally, a high mortality index was reported, especially among poor people. To address this issue, in 2008, Peru initiated several insurance treatment plans of oncological diseases with promising results. In Mexico, there is a high predominance of gastric cancer in male gender compared to female gender, even reaching a 2/1 ratio, and the detection rate of early gastric cancer is low (10% to 20%) which results in a mainly palliative treatment with an overall survival rate in 5 years about 10% to 15% only...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28616603/current-practice-for-gastric-cancer-treatment-in-ukraine
#9
REVIEW
Andrii Sydiuk
Ukraine registers more than 8,000 new cases of gastric cancer (GC) annually. The disease is usually diagnosed at stage III-IV (65% of cases) and 62.2% of patients die within 1 year. About 70% of patients with GC need chemotherapy, and for most of them, this is the only way to increase their life expectancy. An unsolved problem of nationwide importance is achieving the early diagnosis of GC, which predetermines the treatment outcome. The 5-year survival rate for GC patients in Ukraine is only 13%, while early diagnosed GC is almost totally curable using surgery...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28616601/minimally-invasive-surgery-for-gastric-cancer-in-brazil-current-status-and-perspectives-a-report-from-the-brazilian-laparoscopic-oncologic-gastrectomy-group-blogg
#10
REVIEW
Paulo Kassab, Wilson Luiz da Costa, Carlos Eduardo Jacob, Roberto de Moraes Cordts, Osvaldo Antônio Prado Castro, Leandro Cardoso Barchi, Ivan Cecconello, Amir Zeide Charruf, Felipe José Fernández Coimbra, Antônio Moris Cury, Alessandro Landskron Diniz, Igor Correia de Farias, Wilson Rodrigues de Freitas, André Luis de Godoy, Elias Jirjoss Ilias, Carlos Alberto Malheiros, Marcus Fernando Kodama Pertille Ramos, Heber Salvador de Castro Ribeiro, André Roncon Dias, Fábio Rodrigues Thuler, Osmar Kenji Yagi, Laércio Gomes Lourenço, Bruno Zilberstein
The minimally invasive surgery for gastric cancer in Brazil has begun about two years after the first laparoscopic gastrectomy (LG) performed by Kitano in Japan, in 1991. Although the report of first surgeries shows the year of 1993, there was no dissemination of the technique until the years 2010. At that time with the improvement of optical devices, laparoscopic instruments and with the publications coming from Asia, several Brazilian surgeons felt encouraged to go to Korea and Japan to learn the standardization of the LG...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28616598/laparoscopic-sentinel-node-navigation-surgery-for-early-gastric-cancer
#11
REVIEW
Shinichi Kinami, Takeo Kosaka
Currently, the most accurate method for identifying lymph node metastasis is intraoperative diagnosis by sentinel node (SN) biopsy. Based on the SNNS study-a recent large-scale, nationwide, multicenter prospective study-the SN concept seems to be scientifically valid in patients with early gastric cancer. SN biopsy is a multistep technique consisted of six essential elements: indication, the selection of a tracer, a proper tracer injection method, the objective detection of SNs, a reliable biopsy technique, and the precise detection of nodal metastasis...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28616596/laparoscopic-endoscopic-cooperative-surgery-lecs-for-the-upper-gastrointestinal-tract
#12
REVIEW
Tatsuo Matsuda, Souya Nunobe, Manabu Ohashi, Naoki Hiki
We developed the laparoscopic and endoscopic cooperative surgery (LECS) technique, which combines endoscopic submucosal dissection (ESD) and laparoscopic gastric resection to resect gastric submucosal tumors (SMTs). Many researchers have reported LECS to be a feasible technique for gastric submucosal tumor resection regardless of tumor location, including the esophagogastric junction (EGJ). Recently, the Japanese National Health Insurance system approved LECS for insurance coverage, and it is now widely applied for gastric submucosal tumor resection...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28616404/complications-following-endoscopic-submucosal-dissection-for-gastric-esophageal-and-colorectal-cancer-a-review-of-studies-based-on-nationwide-large-scale-databases
#13
REVIEW
Hiroyuki Odagiri, Hideo Yasunaga
Endoscopic submucosal dissection (ESD) is a relatively new procedure used for the treatment of early gastrointestinal cancers regardless of the lesion size and configuration, and it has gradually acquired popularity because of its minimally invasive nature. As compared to conventional endoscopic resection, ESD is a more complex procedure and requires a higher level of technical skill. Therefore, it is associated with a higher complication rate. Many previous studies that investigated the complication rates following ESD analyzed data from a limited number of specialized centers, possibly leading to an underestimation of the complication rates...
April 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28616085/helicobacter-pylori-infection-old-and-new
#14
REVIEW
S Diaconu, A Predescu, A Moldoveanu, C S Pop, C Fierbințeanu-Braticevici
Helicobacter pylori is a spiral-shaped bacterium that grows in the digestive tract and may be present in more than half of the world's population. The clinical features of Helicobacter pylori range from asymptomatic gastritis to gastrointestinal malignancy. Mucosa-associated lymphoid tissue (MALT) lymphoma is a low-grade B-cell marginal zone lymphoma and Helicobacter pylori has been detected in more than 75% of the patients with MALT lymphoma. Many tests for the detection of Helicobacter pylori are available, including antibody tests, urea breath tests, stool antigen tests and endoscopic biopsies...
April 2017: Journal of Medicine and Life
https://www.readbyqxmd.com/read/28612708/contribution-of-matrix-metalloproteinases-1-genotypes-to-gastric-cancer-susceptibility-in-taiwan
#15
Mei-Due Yang, Kuo-Cheng Lin, Meng-Chun Lu, Long-Bin Jeng, Chieh-Lun Hsiao, Te-Cheng Yueh, Chun-Kai Fu, Hsin-Ting Li, Shiou-Ting Yen, Chia-Wen Lin, Cin-Wun Wu, Su-Yi Pang, Da-Tian Bau, Fuu-Jen Tsai
Expression of matrix metalloproteinase-1 (MMP1), an interstitial collagenase regulating the extracellular matrix, plays a major role in carcinogenesis of gastric cancer, a leading cause of death worldwide. In literature, the single-nucleotide polymorphism (SNP) promoter -1607 1G/2G (rs1799750) at the MMP1 gene promoter has been reported to alter its own transcription level. While the importance's of the genotype of MMP1 promoter -1607 has not yet been studied in gastric cancer in Taiwan, our aim was to investigate MMP1 promoter -1607 genotypes and gastric cancer (GC) susceptibility in central Taiwan population...
June 2017: BioMedicine
https://www.readbyqxmd.com/read/28609819/future-development-of-endoscopic-accessories-for-endoscopic-submucosal-dissection
#16
REVIEW
Jae-Young Jang
Endoscopic submucosal dissection (ESD) has recently been accepted as a standard treatment for patients with early gastric cancer (EGC), without lymph node metastases. Given the rise in the number of ESDs being performed, new endoscopic accessories are being developed and existing accessories modified to facilitate the execution of ESD and reduce complication rates. This paper examines the history underlying the development of these new endoscopic accessories and indicates future directions for the development of these accessories...
May 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28607596/elevated-preoperative-neutrophil-to-lymphocyte-ratio-can-predict-poor-survival-in-early-stage-gastric-cancer-patients-receiving-radical-gastrectomy-the-fujian-prospective-investigation-of-cancer-fiesta-study
#17
Dan Hu, Hejun Zhang, Xiandong Lin, Gang Chen, Chao Li, Binying Liang, Yan Chen, Zhaolei Cui, Feng Peng, Xiongwei Zheng, Wenquan Niu
Aims: This cohort study was conducted to evaluate the prognostic impact of blood-routine parameters before radical gastrectomy on gastric cancer mortality. Methods: Total 3012 patients with gastric cancer were consecutively enrolled from a mono-center between 2000 and 2010, and the latest follow-up was completed in 2015. Results: The median follow-up time was 44.05 months. Finally, 1331 out of 3012 gastric cancer patients died from gastric cancer. Per standard deviation increment in neutrophil (hazard ratio or HR=1...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28603669/combining-multi-dimensional-data-to-identify-key-genes-and-pathways-in-gastric-cancer
#18
Wu Ren, Wei Li, Daguang Wang, Shuofeng Hu, Jian Suo, Xiaomin Ying
Gastric cancer is an aggressive cancer that is often diagnosed late. Early detection and treatment require a better understanding of the molecular pathology of the disease. The present study combined data on gene expression and regulatory levels (microRNA, methylation, copy number) with the aim of identifying key genes and pathways for gastric cancer. Data used in this study was retrieved from The Cancer Genomic Atlas. Differential analyses between gastric cancer and normal tissues were carried out using Limma...
2017: PeerJ
https://www.readbyqxmd.com/read/28600636/results-of-a-nationwide-questionnaire-based-survey-on-nutrition-management-following-gastric-cancer-resection-in-japan
#19
Nobuyuki Shimizu, Fumihiko Hatao, Kazuhiko Fukatsu, Susumu Aikou, Yukinori Yamagata, Kazuhiko Mori, Hiroharu Yamashita, Sachiyo Nomura, Yasuyuki Seto
PURPOSE: A study was conducted to clarify the actual status of nutrition management after gastric cancer surgery in Japan and obtain basic data for optimizing perioperative nutrition management. METHODS: A questionnaire was sent to 354 hospitals with at least 50 cases of gastric cancer surgery per year. Questions included the perioperative nutrition management and length of hospital stay for patients who underwent gastric cancer surgery within three months of the survey...
June 9, 2017: Surgery Today
https://www.readbyqxmd.com/read/28597982/a-rare-case-of-epstein-barr-virus-associated-early-gastric-cancer-with-multiple-synchronous-intramucosal-lesions
#20
Katsuyuki Murai, Naomi Kakushima, Kimihide Kusafuka
Epstein-Barr virus-associated gastric cancer (EBV-GC) accounts for 8.7% of gastric cancer.(1) EBV-GC is associated with lower prevalence of lymph node metastasis (LNM), and better prognosis.(1-3) However, little is known regarding intramucosal EBV-GC. We report a case of multiple synchronous lesions of intramucosal EBV-GC. This article is protected by copyright. All rights reserved.
June 9, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
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