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Early gastric cancer

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https://www.readbyqxmd.com/read/28104131/chemotherapy-for-de-novo-gastric-adenocarcinoma-after-deceased-orthotopic-liver-transplantation-a-case-report
#1
J Zhang, S Zhou, H Wang, H Ren, Y Sun, Z Liu
BACKGROUND: De novo gastric cancer is a rare complication of liver transplantation. METHODS: Surgical treatments of 16 cases with different outcomes were reported in the English literature. RESULTS: De novo gastric cancer (stage II) was diagnosed as the result of epi-gastric discomfort in a recipient 10 years after liver transplantation. The patient received chemotherapy alone and remained well for 26 months. CONCLUSIONS: De novo gastric cancer of liver transplantation recipients is a severe complication; early detection and relevant intervention will benefit these recipients...
January 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28101302/robot-assisted-laparoscopic-gastrectomy-for-gastric-cancer
#2
REVIEW
Stefano Caruso, Franco Franceschini, Alberto Patriti, Franco Roviello, Mario Annecchiarico, Graziano Ceccarelli, Andrea Coratti
Phase III evidence in the shape of a series of randomized controlled trials and meta-analyses has shown that laparoscopic gastrectomy is safe and gives better short-term results with respect to the traditional open technique for early-stage gastric cancer. In fact, in the East laparoscopic gastrectomy has become routine for early-stage gastric cancer. In contrast, the treatment of advanced gastric cancer through a minimally invasive way is still a debated issue, mostly due to worries about its oncological efficacy and the difficulty of carrying out an extended lymphadenectomy and intestinal reconstruction after total gastrectomy laparoscopically...
January 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28100369/-innovations-on-technology-management-and-concept-are-indispensible-for-scientific-research-prevention-and-treatment-of-malignant-tumor-in-china
#3
G W Cao
Malignant tumor has become the top cause of deaths before the average life expectancy in Chinese population. From the variations in the morbidity rate and mortality rate of malignant tumor in the mainland of China between 2000 and 2011, the primary prevention targeting the risk factors/etiological agents significantly reduced the morbidity rates of gastric cancer, esophageal cancer, and primary liver cancer, therefore reduced the mortality rates of these cancers. However, the contribution of clinical treatments to the mortality reduction was not obviously improved during this period...
January 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28100248/mediastinal-lymph-node-dissection-and-distal-esophagectomy-is-not-essential-in-early-esophagogastric-junction-adenocarcinoma
#4
In-Seob Lee, Ji-Yong Ahn, Jeong-Hwan Yook, Byung-Sik Kim
BACKGROUND: Optimal extent of surgery remains controversial in types 2 and 3 adenocarcinoma of esophagogastric junction (AEG). We aimed to determine whether the extended procedure including mediastinal lymphadenectomy is essential in all patients with AEG by comparing prognosis and recurrence of proximal gastric adenocarcinoma based on total gastrectomy with intra-abdominal lymphadenectomy. METHODS: The clinicopathologic characteristics of 672 patients (type 2: 90, type 3: 211, upper third of the stomach: 371 cases) who underwent curative total gastrectomy with lymphadenectomy between 2003 and 2009 were reviewed...
January 18, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28099943/a-nomogram-to-predict-lymph-node-metastasis-in-patients-with-early-gastric-cancer
#5
Chun Guang Guo, Dong Bing Zhao, Qian Liu, Zhi Xiang Zhou, Ping Zhao, Gui Qi Wang, Jian Qiang Cai
BACKGROUND: Lymph node status is crucial to determining treatment for early gastric cancer (EGC). We aim to establish a nomogram to predict the possibility of lymph node metastasis (LNM) in EGC patients. METHODS: Medical records of 952 EGC patients with curative resection, from 2002 to 2014, were retrospectively retrieved. Univariate and multivariate analysis were performed to examine risk factors associated with LNM. A nomogram for predicting LNM was established and internally validated...
January 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28096520/differences-in-prevalence-of-lymphovascular-invasion-among-early-gastric-cancers-between-korea-and-japan
#6
Sun-Young Lee, Naohisa Yoshida, Osamu Dohi, Sang Pyo Lee, Daisuke Ichikawa, Jeong Hwan Kim, In-Kyung Sung, Hyung Seok Park, Eigo Otsuji, Yoshito Itoh, Chan Sup Shim, Hye Seung Han, Mitsuo Kishimoto, Yuji Naito
Background/Aims: The presence of invasion is a diagnostic criterion of early gastric cancer (EGC) in Korea, whereas diagnosis in Japan is based on enlarged nuclei and prominent nucleoli. Moreover, the depth of invasion is the location of cancer cell infiltration in Korea, whereas it is the location of lymphovascular invasion (LVI) or cancer cell infiltration in Japan. We evaluated the characteristics of EGC with LVI to uncover the effects of different diagnostic criteria. Methods: Consecutive T1-stage EGC patients who underwent complete resection were included after endoscopic or surgical resection...
January 20, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28090507/gastric-cancer-in-pregnancy-is-laparoscopic-gastrectomy-with-lymph-node-dissection-feasible-and-safe
#7
Amer Saeed Alshahrani, Moon-Won Yoo
Gastric cancer with pregnancy is rare and usually presents in late and advanced stage. Standard interventions in diagnosing, staging and treatment of cancer may be harmful for the fetus. The treatment of cancer in pregnancy should not differ significantly from the treatment in nonpregnant women. There have been case reports of open gastrectomy for gastric cancer in pregnancy. We present a case of early gastric cancer in a 37-year-old pregnant woman treated with laparoscopic distal gastrectomy with lymph node dissection with no postoperative complications...
January 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28072871/atrophic-and-metaplastic-progression-in-the-background-mucosa-of-patients-with-gastric-adenoma
#8
Hee Kyong Na, Charles J Cho, Suh Eun Bae, Jeong Hoon Lee, Young Soo Park, Ji Yong Ahn, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Se Jin Jang, Hwoon-Yong Jung
BACKGROUND: In patients with adenoma, assessing premalignant changes in the surrounding mucosa is important for surveillance. This study evaluated atrophic and metaplastic progression in the background mucosa of adenoma or early gastric cancer (EGC) cases. METHODS: Among 146 consecutive patients who underwent endoscopic resection for intestinal-type gastric neoplasia, the adenoma group included 56 patients with low-grade dysplasia and the ECG group included 90 patients with high-grade dysplasia or invasive carcinoma...
2017: PloS One
https://www.readbyqxmd.com/read/28070097/a-well-differentiated-early-gastric-cancer-in-a-patient-confirmed-negative-for-helicobacter-pylori
#9
Narihiro Shibukawa, Shuji Wakamatsu, Shohei Ouchi, Yuhei Wakahara, Nobuyuki Tatsumi, Akira Kaneko
A woman in her 70s was an outpatient at our hospital. Esophagogastroduodenoscopy revealed a slightly elevated lesion with erosion, 10mm in diameter, located at the greater curvature of the antrum. Helicobacter pylori testing yielded negative results, and there was no atrophy of the gastric mucosa. Biopsy revealed a well-differentiated tubular adenocarcinoma. Complete en bloc resection was performed via endoscopic submucosal dissection, in accordance with the current Japanese guidelines. The gastric adenocarcinoma of the fundic gland type and coexisting with a hyperplastic or fundic gland polyp was negative according to the histological examination...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/28064445/a-panel-of-autoantibodies-against-multiple-tumor-associated-antigens-for-detecting-gastric-cancer
#10
Isamu Hoshino, Matsuo Nagata, Nobuhiro Takiguchi, Yoshihiro Nabeya, Atsushi Ikeda, Sana Yokoi, Akiko Kuwajima, Masatoshi Tagawa, Kazuyuki Matsushita, Yajima Satoshi, Shimada Hideaki
Gastric cancer is the second leading cause of cancer deaths in the world, and effective diagnosis is extremely important for good outcome. We assessed the diagnostic potential of an autoantibody panel that may provide a novel tool for the early detection of gastric cancer. We analyzed data from patients with gastric cancer and normal controls in a test and validation cohorts. Autoantibody levels were measured against a panel of six tumor-associated antigens [TAAs; p53, heat shock protein 70 (HSP70), HCC-22-5, peroxiredoxin VI (Prx VI), KM-HN-1, and p90 TAA (CYP2A)] via ELISA...
January 8, 2017: Cancer Science
https://www.readbyqxmd.com/read/28061480/co-ordinated-overexpression-of-sirt1-and-stat3-is-associated-with-poor-survival-outcome-in-gastric-cancer-patients
#11
Shu Zhang, Shuling Huang, Chao Deng, Yu Cao, Jun Yang, Guangxia Chen, Bin Zhang, Chaoqin Duan, Jiong Shi, Bo Kong, Helmut Friess, Nanyi Zhao, Chen Huang, Xiaoli Huang, Lei Wang, Xiaoping Zou
In many gastric cancer patients, the disease is diagnosed in an advanced stage and therefore the mortality levels are high. Because there is a need to identify novel early diagnostic and prognostic biomarkers, we tested whether SIRT1 and STAT3 are good candidates. Towards this, we used patient tissues representing different stages of gastric cancer including gastric pre-cancerous lesions, early gastric cancer, and advanced gastric cancer, and probed SIRT1, STAT3 and phosphorylated STAT3 (pSTAT3) levels using immunohistochemistry...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28060554/current-molecular-and-genetic-aspects-of-pancreatic-cancer-the-role-of-metastasis-associated-proteins-mta-a-review
#12
Efstathios T Pavlidis, Theodoros E Pavlidis
: Purpose/aim: To focus on current molecular and genetic aspects and MTA proteins, since pancreatic cancer is a lethal malignant with poor prognosis. Early diagnosis is essential step, contributing to potential curative resection. MATERIALS AND METHODS: A PubMed search of relevant articles published up to August 2016 was performed to identify current information about pancreatic cancer regarding molecular biomarkers, with emphasis on carcinogenesis, novel therapeutic targets, and MTA proteins...
January 6, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28056871/lung-adenocarcinoma-expressing-receptor-for-advanced-glycation-end-products-with-primary-systemic-al-amyloidosis-a-case-report-and-literature-review
#13
Shouichi Okamoto, Shinsaku Togo, Ichiro Nagata, Kazue Shimizu, Yoshika Koinuma, Yukiko Namba, Jun Ito, Toshimasa Uekusa, Kazuhisa Takahashi
BACKGROUND: Receptor for advanced glycation end-products (RAGE), a receptor for amyloids, is constitutively expressed in lungs and generally observed to be downregulated in lung cancer tissues. However, increasing levels of RAGE or serum amyloids is associated with poor outcome in lung cancer patients. We report a rare case of primary systemic amyloid light-chain (AL) amyloidosis in biopsy-proven multiple organs with early-stage non-small cell lung cancer (NSCLC) that displayed strong staining for RAGE in the tumour tissue...
January 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28055269/targeting-pd-1-pathway-a-new-hope-for-gastrointestinal-cancers
#14
Burak Bilgin, Mehmet An Sendur, Muhammed Bülent Akıncı, Didem Şener Dede, Bülent Yalçın
BACKGROUND: VEGF, HER2 and EGFR targeted agents are currently used in gastric, esophageal and colorectal cancers. However, treatment outcomes are still poor in most of the Gastrointestinal (GI) cancers. Immune checkpoints are one of the most promising immunotherapy approaches. In this review article, we aimed to discuss the efficacy and safety of anti-PD-1/PD-L1 therapies in GI cancers, including gastric, esophageal and colorectal cancer in the era of published or reported recent studies...
January 5, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28054971/the-development-of-urease-inhibitors-what-opportunities-exist-for-better-treatment-of-helicobacter-pylori-infection-in-children
#15
Sherif T S Hassan, Miroslava Šudomová
Stomach infection with Helicobacter pylori (H. pylori) causes severe gastroduodenal diseases in a large number of patients worldwide. The H. pylori infection breaks up in early childhood, persists lifelong if not treated, and is associated with chronic gastritis and an increased risk of peptic ulcers and gastric cancer. In recent years, the problem of drug-resistant strains has become a global concern that makes the treatment more complicated and the infection persistent at higher levels when the antibiotic treatment is stopped...
January 4, 2017: Children
https://www.readbyqxmd.com/read/28053963/expression-of-leucine-rich-repeat-containing-g-protein-coupled-receptor-5-and-cd44-potential-implications-for-gastric-cancer-stem-cell-marker
#16
Yoon Jin Choi, Nayoung Kim, Hye Seung Lee, Seon Mee Park, Ji Hyun Park, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Jin-Wook Kim, Dong Ho Lee
BACKGROUND: The human leucine-rich repeat-containing G-protein coupled receptor (LGR) 5 and CD44 are one of the candidates for the marker of gastric cancer stem cells. We compared the expressions of two genes among control, dysplasia and cancer groups. METHODS: We compared the mRNA expression of LGR5, CD44 and CD44v8-10 and immunohistochemistry (IHC) of LGR5 and CD44 in gastric antral mucosa of 45 controls, 36 patients with gastric dysplasia, and 39 patients with early gastric cancer...
December 2016: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28050659/ischemic-gastric-conditioning-by-preoperative-arterial-embolization-before-oncologic-esophagectomy-a-single-center-experience
#17
Julien Ghelfi, Pierre-Yves Brichon, Julien Frandon, Bastien Boussat, Ivan Bricault, Gilbert Ferretti, Sébastien Guigard, Christian Sengel
PURPOSE: Surgical esophagectomy is the gold standard treatment of early-stage esophageal cancer. The procedure is complicated with significant morbidity; the most severe complication being the anastomotic leakage. Anastomotic fistulas are reported in 5-25% of cases and are mainly due to gastric transplant ischemia. Here, we report our experience of ischemic pre-conditioning using preoperative arterial embolization (PreopAE) before esophagectomy. MATERIALS AND METHODS: The medical records of all patients who underwent oncologic esophagectomy from 2008 to 2015 were retrospectively reviewed...
January 3, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28046028/predictive-value-of-stemness-factor-sox2-in-gastric-cancer-is-associated-with-tumor-location-and-stage
#18
Lang Yang, Jun-Feng Xu, Qian Kang, Ai-Qin Li, Peng Jin, Xin Wang, Yu-Qi He, Na Li, Tao Cheng, Jian-Qiu Sheng
Cancer stem cells (CSCs) are thought to be the "root" of cancer. Although stemness-related factors ALDH1A1 and Sox2 have been used as markers to identify gastric CSCs, the expression pattern and significance of these factors in gastric cancer have not been sufficiently demonstrated. In this study, the expressions of ALDH1A1 and Sox2 were detected by immunohistochemistry in 122 gastric cancer specimens. And the correlation between Sox2 or ALDH1A1 expression and clinicopathological parameters and overall survival data were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28042388/evidence-based-review-of-the-impact-of-image-enhanced-endoscopy-in-the-diagnosis-of-gastric-disorders
#19
REVIEW
Ikram Hussain, Tiing Leong Ang
Gastric cancer is the third most common cause of cancer-related death. Advanced stages of gastric cancers generally have grim prognosis. But, good prognosis can be achieved if such cancers are detected, diagnosed and resected at early stages. However, early gastric cancers and its precursors often produce only subtle mucosal changes and therefore quite commonly remain elusive at the conventional examination with white light endoscopy. Image-enhanced endoscopy makes mucosal lesions more conspicuous and can therefore potentially yield earlier and more accurate diagnoses...
December 16, 2016: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28039710/clinicopathological-features-and-prognosis-of-borrmann-type-iv-gastric-cancer
#20
Yan-Li Zhu, Li Yang, Zi-Qi Sui, Liang Liu, Jing-Feng Du
PURPOSE: Borrmann type IV gastric cancer is still detected at an advanced stage and survival rates for these patients remain poor. The purpose of this study was to provide valuable prognostic and surgical information on patients with Borrmann type IV gastric cancer. METHODS: We compared the clinicopathological features of Borrmann type IV gastric cancer with those of other types of gastric cancer. Clinicopathologic features of patients with Borrmann type IV gastric cancer were evaluated as prognostic predictors by univariate and multivariate analyses...
November 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
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