keyword
https://read.qxmd.com/read/38537007/independent-predictors-for-non-alcoholic-fatty-liver-disease-in-patients-with-treatment-na%C3%A3-ve-chronic-hepatitis-b
#1
JOURNAL ARTICLE
Gulsah Tuncer, Ceyda Geyiktepe-Guclu, Osman Faruk Bayramlar, Burcu Atasoy Bozan, Cigdem Yucel, Betul Copur, Kadir Gorkem Guclu, Mustafa Yıldırım, Gonul Sengöz, Filiz Pehlivanoglu
OBJECTIVE: There are limited data on non-alcoholic fatty liver disease in chronic hepatitis B virus infection. We aimed to determine the predictors for non-alcoholic fatty liver disease in patients with treatment-naïve chronic hepatitis B virus infection. METHODS: All consecutive treatment-naïve patients with chronic hepatitis B virus infection at the Haseki Training and Research Hospital between October 1, 2021, and September 31, 2022, were retrospectively enrolled...
2024: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/38535131/cardiometabolic-risk-profiles-of-adolescents-living-with-perinatally-acquired-hiv-in-south-africa
#2
JOURNAL ARTICLE
Leonore Greybe, Shaun Barnabas, Mark Cotton, Penelope Rose, Helena Rabie, Lisa Frigati
BACKGROUND: We assessed the Pathological Determinants of Atherosclerosis in Youth (PDAY) score and other potential cardiovascular disease risk factors in adolescents previously enrolled in the Children with HIV Early antiRetroviral (CHER) and International Maternal Pediatric Adolescent AIDS Clinical Trials Network P1060 clinical trials. METHODS: Coronary artery and abdominal aorta (AA) PDAY scores were calculated for 56 participants over 15 years of age using a weighted combination of dyslipidemia, cigarette smoking, hypertension, obesity, and hyperglycemia...
March 26, 2024: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/38528584/potential-use-of-proprotein-convertase-subtilisin-kexin-type-9-pcsk9-inhibition-and-prevention-method-in-viral-infection
#3
REVIEW
Khursheed Muzammil, Mohammad Hosseini Hooshiar, Shirin Varmazyar, Thabit Moath Omar, Manal Morad Karim, Sadeq Aadi, Shaylan Kalavi, Saman Yasamineh
Cellular lipid membranes serve as the primary barrier preventing viral infection of the host cell and provide viruses with a critical initial point of contact. Occasionally, viruses can utilize lipids as viral receptors. Viruses depend significantly on lipid rafts for infection at virtually every stage of their life cycle. The pivotal role that proprotein convertase subtilisin/kexin Type 9 (PCSK9) plays in cholesterol homeostasis and atherosclerosis, primarily by post-transcriptionally regulating hepatic low-density lipoprotein receptor (LDLR) and promoting its lysosomal degradation, has garnered increasing interest...
March 25, 2024: Microbial Cell Factories
https://read.qxmd.com/read/38500280/interferon-upregulation-associates-with-insulin-resistance-in-humans
#4
JOURNAL ARTICLE
Maria M Adeva-Andany, Natalia Carneiro-Freire, Elvira Castro-Quintela, Eva Ameneiros-Rodriguez, Lucia Adeva-Contreras, Carlos Fernandez-Fernandez
In humans, insulin resistance is a physiological response to infections developed to supply sufficient energy to the activated immune system. This metabolic adaptation facilitates the immune response but usually persists after the recovery period of the infection and predisposes the hosts to type 2 diabetes and vascular injury. In patients with diabetes, superimposed insulin resistance worsens metabolic control and promotes diabetic ketoacidosis. Pathogenic mechanisms underlying insulin resistance during microbial invasions remain to be fully defined...
March 18, 2024: Current Diabetes Reviews
https://read.qxmd.com/read/38483175/efficacy-and-effect-on-lipid-profiles-of-switching-to-ainuovirine-based-regimen-versus-continuing-efavirenz-based-regimen-in-people-with-hiv-1-24-week-results-from-a-real-world-retrospective-multi-center-cohort-study
#5
JOURNAL ARTICLE
Chunmei Wang, Xiaoli Yu, Yingchun Ke, Yanhua Fu, Yanhe Luo, Ying Li, Yanmei Bi, Xingqiong Chen, Linghua Li, Xiuhong Zhao, Zhong Chen
Ainuovirine (ANV), a novel non-nucleoside reverse-transcriptase inhibitor (NNRTI), was approved in China in 2021. In a previous randomized phase 3 trial, ANV demonstrated non-inferior efficacy relative to efavirenz (EFV) and was associated with lower rates of dyslipidemia. In this study, we aimed to explore lipid changes in treatment-experienced people with human immunodeficiency virus (HIV)-1 (PWH) switching to ANV from EFV in real world. At week 24, 96.65% of patients in the ANV group and 93.25% in the EFV group had HIV-1 RNA levels below the limit of quantification (LOQ)...
March 14, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38444823/hypertension-among-cohort-of-persons-with-human-immunodeficiency-virus-initiated-on-a-dolutegravir-based-antiretroviral-regimen-in-ghana
#6
JOURNAL ARTICLE
Margaret Lartey, Kwasi Torpey, Vincent Ganu, Stephen Ayisi Addo, Delia Bandoh, Marijanatu Abdulai, Golda Akuffo, Ernest Kenu
BACKGROUND: Dolutegravir (DTG), a new antiretroviral drug, is being integrated into antiretroviral regimens for people with human immunodeficiency virus (PWH) in Ghana. There is little evidence of the effect of DTG on blood pressure (BP) levels in sub-Saharan Africa, especially West Africa. Our aim was to assess the incidence and predictors of hypertension (HTN) among PWH initiated on a DTG-based antiretroviral regimen in Ghana. METHODS: An observational multicenter longitudinal study was conducted among PWH in Ghana from 2020 to 2022...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38441897/nurse-led-strategy-to-improve-blood-pressure-and-cholesterol-level-among-people-with-hiv-a-randomized-clinical-trial
#7
RANDOMIZED CONTROLLED TRIAL
Christopher T Longenecker, Kelley A Jones, Corrilynn O Hileman, Nwora Lance Okeke, Barbara M Gripshover, Angela Aifah, Gerald S Bloomfield, Charles Muiruri, Valerie A Smith, Rajesh Vedanthan, Allison R Webel, Hayden B Bosworth
IMPORTANCE: Despite higher atherosclerotic cardiovascular disease (ASCVD) risk, people with HIV (PWH) experience unique barriers to ASCVD prevention, such as changing models of HIV primary care. OBJECTIVE: To test whether a multicomponent nurse-led strategy would improve systolic blood pressure (SBP) and non-high-density lipoprotein (HDL) cholesterol level in a diverse population of PWH receiving antiretroviral therapy (ART). DESIGN, SETTING, AND PARTICIPANTS: This randomized clinical trial enrolled PWH at 3 academic HIV clinics in the US from September 2019 to January 2022 and conducted follow-up for 12 months until January 2023...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38429714/association-between-biomarkers-of-inflammation-and-dyslipidemia-in-drug-resistant-tuberculosis-in-uganda
#8
MULTICENTER STUDY
Joseph Baruch Baluku, Robinah Nalwanga, Andrew Kazibwe, Ronald Olum, Edwin Nuwagira, Nathan Mugenyi, Frank Mulindwa, Felix Bongomin
BACKGROUND: Active tuberculosis (TB) significantly increases the risk of cardiovascular disease, but the underlying mechanisms remain unclear. This study aimed to investigate the association between inflammation biomarkers and dyslipidemia in patients with drug-resistant TB (DR-TB). METHODS: This was a secondary analysis of data from a cross-sectional multi-center study in Uganda conducted 2021. Participants underwent anthropometric measurements and laboratory tests included a lipid profile, full haemogram and serology for HIV infection...
March 1, 2024: Lipids in Health and Disease
https://read.qxmd.com/read/38427932/the-impact-of-regular-screening-and-lifestyle-modification-on-cardiovascular-disease-risk-factors-in-south-african-women-living-with-hiv
#9
JOURNAL ARTICLE
Sherika Hanley, Dhayendre Moodley, Mergan Naidoo, Sean S Brummel
BACKGROUND: The ISCHeMiA study set out to determine the effectiveness of screening and lifestyle modification in modifying CVD risk factors in women living with HIV (WLHIV). METHODS: In this prospective quasi-experimental intervention study, WLHIV aged 18-<50 years were enrolled from two clinics (intervention [I-arm) and control arms [C-arm]) in Umlazi, South Africa between November 2018 and May 2019. Women in the I-arm received lifestyle modification advice on diet, physical activity, alcohol use and smoking cessation and underwent annual screening for CVD risk...
March 1, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://read.qxmd.com/read/38371905/cardiovascular-risk-factors-and-carotid-intima-media-thickness-with-neurocognitive-dysfunction-in-people-living-with-hiv-on-stable-combination-anti-retroviral-therapy
#10
JOURNAL ARTICLE
Unnathi Nayak, Nikhil Victor Dsouza, P V Santosh Rai, Basavaprabhu Achappa, Ramesh Holla, B V Murlimanju
The goal of this clinical research was to determine the relationship between carotid intima-media thickness (cIMT), cardiovascular risk factors, and neuro-cognitive function in people living with HIV (PLHIV) and were on stable combination anti-retroviral therapy (cART). This is a cross-sectional study performed at a single center, including 149 patients who visited the anti-retroviral therapy center of our tertiary care hospital. Among the PLHIV of our research, 62.4% had at least one associated cardiovascular risk factor, and 61...
March 2024: 3 Biotech
https://read.qxmd.com/read/38369986/serum-lipid-profiles-blood-glucose-and-high-sensitivity-c-reactive-protein-levels-among-people-living-with-hiv-taking-dolutegravir-and-ritonavir-boosted-atazanavir-based-antiretroviral-therapy-at-jimma-university-medical-center-southwest-ethiopia-2021
#11
JOURNAL ARTICLE
Nuredin Chura Waritu, Suresh Kumar P Nair, Bihonegn Birhan, Tesfaye Adugna, Gesese Bogale Awgichew, Mohammed Jemal
BACKGROUND: Long-term use of antiretroviral therapy, especially dolutegravir and boosted-atazanavir, raises concerns about cardiovascular disease. Thus, this study aimed to assess lipid profiles, blood glucose, and high-sensitivity C-reactive protein levels among people living with HIV on dolutegravir and ritonavir-boosted atazanavir-based therapy. METHODS: An institutional-based comparative cross-sectional study was conducted from November 4, 2021, to January 4, 2022...
2024: HIV/AIDS: Research and Palliative Care
https://read.qxmd.com/read/38323612/sagittal-abdominal-diameter-as-the-best-predictor-of-metabolic-syndrome-in-hiv-infected-men-on-antiretroviral-therapy
#12
JOURNAL ARTICLE
Zorka Drvendžija, Biljana Srdić Galić, Miloš Vujanović, Daniela Marić, Nina Brkić Jovanović, Snežana Brkić, Vesna Turkulov, Dalibor Ilić
BACKGROUND: The interaction of human immunodeficiency virus (HIV), host and antiretroviral therapy causes a range of metabolic disorders that can be characterized as a metabolic syndrome (MetS) that increases the cardiovascular risk. MetS involves central obesity, which can be detected using different anthropometric parameters. OBJECTIVE: To assess the abilities of different anthropometric parameters in the prediction of MetS in HIV-infected men on ART. METHOD: The study involved 92 male participants (mean age 44...
February 7, 2024: Current HIV Research
https://read.qxmd.com/read/38183002/dyslipidemia-among-adult-people-living-with-hiv-on-dolutegravir-based-antiretroviral-therapy-at-a-private-tertiary-hospital-in-kampala-uganda-burden-and-determinants
#13
JOURNAL ARTICLE
Vianney John Kigongo, Joaniter I Nankabirwa, Freddy Eric Kitutu, Ronald Ssenyonga, Ronald Kasoma Mutebi, Andrew Kazibwe, Ronald Kiguba, Andrew D Kambugu, Barbara Castelnuovo
BACKGROUND: Understanding the burden of dyslipidemia and its associated factors among adult people living with HIV on dolutegravir (DTG) based anti-retroviral therapy (ART) is critical to provide clinical guidance and risk reduction strategies in our setting. METHODS: We conducted a cross-sectional study on adult people living with HIV on DTG based ART between July and August 2022 at Mengo Hospital, a private not for profit missionary hospital owned by the Church of Uganda...
January 5, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38173008/brief-communications-changes-in-inflammatory-biomarkers-and-lipid-profiles-after-switching-to-long-acting-cabotegravir-plus-rilpivirine
#14
JOURNAL ARTICLE
Eisuke Adachi, Makoto Saito, Amato Otani, Michiko Koga, Hiroshi Yotsuyanagi
We assessed whether the impact of cabotegravir plus rilpivirine on inflammation reduction differs from that of oral antiretrovirals, using real-world data. Inflammatory biomarkers and lipid profiles were followed from baseline to 8 months after switching. Seventy-eight participants were analyzed. The CD4/CD8 ratio and C-reactive protein did not change. There were transient decreases in CD8 and CD4 counts in the group that switched from the dolutegravir-based regimen, but not in the tenofovir alafenamide-based regimen group...
January 3, 2024: AIDS Research and Therapy
https://read.qxmd.com/read/38166636/dyslipidemia-among-hiv-infected-patients-in-ethiopia-a-systematic-review-and-meta-analysis
#15
JOURNAL ARTICLE
Ousman Mohammed, Ermiyas Alemayehu, Habtu Debash, Melaku Ashagrie Belete, Alemu Gedefie, Mihret Tilahun, Hussen Ebrahim, Daniel Gebretsadik Weldehanna
BACKGROUND: Dyslipidemia is responsible for more than half of the global ischemic heart disease (IHD) and more than 4 million deaths annually. Assessing the prevalence of dyslipidemia can be crucial in predicting the future disease development and possible intervention strategies. Therefore, this systematic review and meta-analysis was aimed at assessing the pooled prevalence of dyslipidemia in HIV-infected patients. METHODS: Electronic databases such as EMBASE, Google Scholar, PubMed, Web of Science, ResearchGate, Cochrane Library, and Science Direct were searched for articles and grey literature...
January 2, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38158594/prevalence-of-risk-factors-for-and-target-organ-damage-from-metabolic-syndrome-among-people-living-with-hiv-on-art-a-cross-sectional-analysis-in-chongqing-china
#16
JOURNAL ARTICLE
Min Liu, Kun He, Yushan Wu, Qing Yu, Nannan Sun, Xiaochun Teng, Xianqin Meng, Jing Yuan, Honghong Yang
INTRODUCTION: The incidence of metabolic syndrome (MetS) in people living with HIV is significantly higher than in people without HIV. MetS is not only a major driver of cardiovascular disease (CVD) but is also closely related to the development of chronic kidney disease (CKD). The aim of this study was to investigate the prevalence of and risk factors for MetS and to further understand the degree of damage to target organs. METHODS: This was a cross-sectional descriptive study conducted at Chongqing Public Health Medical Center, China...
December 29, 2023: HIV Medicine
https://read.qxmd.com/read/38145183/prevalence-of-dysglycemia-dyslipidemia-and-metabolic-syndrome-among-patients-with-hiv-infection-a-cross-sectional-study-from-iran
#17
JOURNAL ARTICLE
Marjan Shakiba, Shervin Shokouhi, Fariba Alaei, Amirreza Keyvanfar, Hanieh Najafiarab, Mehrdad Yasaei
BACKGROUND: Human immunodeficiency virus (HIV) resulted in considerable morbidity and mortality. Following antiretroviral therapy (ART), the life expectancy of HIV-infected patients increased; however, they were more at risk of developing chronic diseases such as endocrinopathies. This study aimed to determine the prevalence of dysglycemia, dyslipidemia, and metabolic syndrome among patients with HIV infection. METHODS: This cross-sectional study was conducted on HIV-infected patients referring to Loghman Hakim Hospital (Tehran, Iran) between April 2020 and April 2021...
2023: Medical Journal of the Islamic Republic of Iran
https://read.qxmd.com/read/38141189/older-plhiv-are-at-higher-cardiovascular-risk-with-poor-quality-of-life
#18
JOURNAL ARTICLE
Muhammed Shabil, Krishna Murti, V Udaya Kumar, Rishkesh Kumar, Nitesh Kumar, Sameer Dhingra, Vipan Kumar Parihar, V Ravichandiran, Krishna Pandey
BACKGROUND: People with HIV (PLHIV) face increased cardiovascular disease (CVD) risk due to inflammation and immune activation. Aging further amplifies this risk. Limited data exist on CVD risk in older PLHIV in India despite 2.14 million PLHIV with higher CVD risk factors. METHODS: In a cross-sectional study in Bihar, India, 73 PLHIV and 30 control participants were enrolled. Demographics, social factors, clinical information, and CVD risk factors were collected...
December 21, 2023: Current HIV Research
https://read.qxmd.com/read/38118463/blood-glucose-level-and-serum-lipid-profiles-among-people-living-with-hiv-on-dolutegravir-based-versus-efavirenz-based-cart-a-comparative-cross-sectional-study
#19
JOURNAL ARTICLE
Mohammed Jemal, Tewodros Shibabaw Molla, Markeshaw Tiruneh G Medhin, Endeshaw Chekol Abebe, Tadesse Asmamaw Dejenie
BACKGROUND: Antiretroviral therapy-linked metabolic abnormalities have become a growing concern among people living with HIV. There is limited data regarding the effects of dolutegravir-based treatment on blood glucose levels and serum lipid profiles in people living with HIV in Ethiopia. Thus, this study aimed to assess blood glucose levels and serum lipid profiles among people living with HIV on dolutegravir-based versus efavirenz-based therapy. METHOD AND MATERIALS: An institutional-based comparative cross-sectional study was conducted from 30 June 2021 to 30 August 2021...
2023: Annals of Medicine
https://read.qxmd.com/read/38108976/lipoproteins-in-negative-feedback-with-alpha-1-antitrypsin
#20
JOURNAL ARTICLE
Cynthia L Bristow
Alpha-1 antitrypsin deficiency patients (AATD) have lower risk of myocardial infarction, a cardiovascular disease that is related to increased remnant cholesterol levels, but not to low-density lipoprotein (LDL) levels. However, when AAT is knocked out in mice (AAT-KO), inflammatory-related, cholesterol metabolism-related, and lipid metabolism-related gene expression in mouse liver was increased, and these data support previous evidence from clinic patients and from a small clinical trial that AAT is in negative feedback regulation with LDL...
2024: Methods in Molecular Biology
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