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https://www.readbyqxmd.com/read/27904105/evaluation-of-the-lipid-concentrations-after-switching-from-antiretroviral-drug-tenofovir-disoproxil-fumarate-emtricitabine-to-abacavir-sulfate-lamivudine-in-virologically-suppressed-human-immunodeficiency-virus-infected-patients
#1
Hirotaka Arae, Masao Tateyama, Hideta Nakamura, Daisuke Tasato, Kaoru Kami, Kyoko Miyagi, Saori Maeda, Hitoshi Uehara, Makiko Moromi, Katsunori Nakamura, Jiro Fujita
Objective Recently, tenofovir disoproxil fumatate (TDF)-related side effects, such as renal nephrotoxicity and reduction of bone mineral density, have been reported. Consequently, increased switching from fixed-dose tablet TDF and emtricitabine (TDF/FTC) to abacavir and lamivudine (ABC/3TC) has occurred. Interestingly, while TDF has a lipid-lowering property, one of the ABC-related side effects is hyperlipidemia. Therefore, such switching could cause lipid elevation. To evaluate the change in lipid levels associated with switching from TDF/FTC to ABC/3TC in virologically-suppressed human immunodeficiency virus (HIV)-infected patients...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27864732/impact-of-pharmaceutical-care-on-cardiovascular-risk-among-older-hiv-patients-on-antiretroviral-therapy
#2
Elza Aparecida Machado Domingues, Mónica Ferrit-Martín, Miguel Ángel Calleja-Hernández
Background Advances in the treatment of HIV infection have enabled better control of the disease, allowing patients to enjoy a longer life expectancy. However, the ageing of patients leads to an increased prevalence of cardiovascular disease. Various studies have found that pharmaceutical care results in better control of cardiovascular risk factors. Objective To measure the impact of pharmaceutical care on cardiovascular risk in patients older than 50 years receiving combination antiretroviral therapy. Setting Outpatient pharmacy service of a tertiary hospital, Spain...
November 18, 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27822124/changes-in-coronary-heart-disease-risk-profiles-of-hiv-patients-in-zimbabwe-over-9-months-a-follow-up-study
#3
Danai Tavonga Zhou, Olav Oektedalen, Sandra Shawarira-Bote, Babill Stray-Pedersen
Dyslipidemia, hypertension, inflammation, and coronary heart disease (CHD) are adverse events in human immunodeficiency virus (HIV)-infected patients even if they are receiving antiretroviral therapy (ART). Yet, data on CHD risk induced by HIV or ART in sub-Saharan Africa are limited. The aim of this longitudinal study was to describe changes in CHD risk profiles measured by lipids, inflammatory markers, and Framingham scores among HIV-positive patients previously reported from Harare, Zimbabwe. Patients were grouped into ART-experienced patients (n=147) and ART-naïve patients (n=23) and followed up for 9 months...
2016: HIV/AIDS: Research and Palliative Care
https://www.readbyqxmd.com/read/27759575/changes-in-urinary-biomarkers-over-10-years-is-associated-with-viral-suppression-in-a-prospective-cohort-of-women-living-with-hiv
#4
Sanjiv M Baxi, Rebecca Scherzer, Vasantha Jotwani, Michelle M Estrella, Alison G Abraham, Chirag R Parikh, Michael R Bennett, Mardge H Cohen, Marek J Nowicki, Deborah R Gustafson, Anjali Sharma, Mary A Young, Michael G Shlipak
BACKGROUND: Urine biomarkers have helped identify persons at risk for progressing to kidney disease in the setting of HIV infection. We explored factors associated with changes in three urine biomarkers over 10 years among women living with HIV. METHODS: Prospective cohort of 294 HIV-infected women from the multicenter Women's Interagency HIV Study (WIHS). Predictors included HIV viral and immunological parameters, co-morbid conditions and health-related behaviors...
October 18, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27753678/statin-drugs-decrease-progression-to-cirrhosis-in-hiv-hepatitis-c-virus-coinfected-individuals
#5
Nora T Oliver, Christine M Hartman, Jennifer R Kramer, Elizabeth Y Chiao
INTRODUCTION: Chronic HIV/hepatitis C virus (HCV) coinfection carries increased risk of cirrhosis, hepatocellular carcinoma, and death. Due to anti-inflammatory properties, 3-hydroxy-3methylglutaryl coenzyme A (HMG-CoA) inhibitors (statins) may be useful adjunctive therapy to reduce liver disease progression. METHODS: Clinical information was extracted from the Veterans Affairs HIV and HCV Clinical Case Registries (1999-2010). HIV-related variables included combination antiretroviral therapy era of diagnosis, CD4 cell count, and percentage time with undetectable HIV viral load...
October 23, 2016: AIDS
https://www.readbyqxmd.com/read/27749649/safety-and-efficacy-of-atorvastatin-in-human-immunodeficiency-virus-infected-children-adolescents-and-young-adults-with-hyperlipidemia
#6
Ann J Melvin, Grace Montepiedra, Lisa Aaron, William A Meyer, Hans M Spiegel, William Borkowsky, Mark J Abzug, Brookie M Best, Marilyn J Crain, Peggy R Borum, Bobbie Graham, Patricia Anthony, Katherine Shin, George K Siberry
BACKGROUND: HIV-infected children receiving antiretroviral therapy (ART) have increased prevalence of hyperlipidemia and risk factors for cardiovascular disease. No studies have investigated the efficacy and safety of statins in this population. METHODS: HIV-infected youth aged 10 - < 24 years on stable ART with low-density lipoprotein-cholesterol (LDL-C) ≥130 mg/dL for ≥ 6 months initiated atorvastatin 10mg once daily. Atorvastatin was increased to 20mg if LDL-C efficacy criteria (LDL-C < 110 mg/dL or decreased ≥30% from baseline) were not met at week 4...
October 3, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27740536/treatment-of-hiv-infection-with-a-raltegravir-based-regimen-increases-ldl-levels-but-improves-hdl-cholesterol-efflux-capacity
#7
Nicholas T Funderburg, Dihua Xu, Martin P Playford, Aditya A Joshi, Adriana Andrade, Daniel R Kuritzkes, Michael M Lederman, Nehal N Mehta
BACKGROUND: Persons infected with HIV often have altered lipid profiles that may be affected by antiretroviral therapies (ART). Traditional lipid measurements may be insufficient to assess cardiovascular disease (CVD) risk in this population. METHODS: We report results from 39 ART-naïve participants in a substudy of A5248, a single-arm study of raltegravir (RAL), emtricitabine/tenofovir administration. Samples were collected at baseline, 12, 24, and 48 weeks after ART initiation...
October 14, 2016: Antiviral Therapy
https://www.readbyqxmd.com/read/27727770/hdl-cholesterol-as-a-predictor-of-cd4-count-in-hiv-infected-patients-taking-nnrti-based-haart-regimen-at-tertiary-care-art-centre-in-mysore
#8
Soumya K, Rangaswamy
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27603338/high-density-lipoprotein-cholesterol-levels-and-risk-of-cancer-in-hiv-infected-subjects-data-from-the-icona-foundation-cohort
#9
Nicola Squillace, Laura Galli, Alessandra Bandera, Antonella Castagna, Giordano Madeddu, Pietro Caramello, Andrea Antinori, Annamaria Cattelan, Franco Maggiolo, Antonella Cingolani, Andrea Gori, Antonella d'Arminio Monforte
Investigation of the relationship between high-density lipoprotein-cholesterol (HDL-c) and the risk of developing cancer in a prospective cohort of human immunodeficiency virus (HIV)-infected patients.The Italian Cohort of Antiretroviral-naïve Patients Foundation Cohort is an Italian multicenter observational study recruiting HIV-positive patients while still antiretroviral treatment-naïve, regardless of the reason since 1997.Patients with at least 1 HDL-c value per year since enrollment and one such value before antiretroviral treatment initiation were included...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27600391/lipids-profile-among-art-na%C3%A3-ve-hiv-infected-patients-and-men-who-have-sex-with-men-in-china-a-case-control-study
#10
Qi Wang, Haibo Ding, Junjie Xu, Wenqing Geng, Jing Liu, Xiaolin Guo, Jing Kang, Xiaolin Li, Yongjun Jiang, Hong Shang
BACKGROUND: Dyslipidemia is commonly seen in human immunodeficiency virus (HIV) infected patients. Understanding the risk factors of abnormal lipid profiles is urgent for proposing targeted approaches to prevention. Our objective was to assess the incidence and associated factors of abnormal lipid profiles and atherogenic index of plasma (AIP) among antiretroviral therapy (ART) naïve men who have sex with men (MSM) acute HIV infection (AHI) and chronic HIV infection (CHI) patients in China...
2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27591292/effectiveness-and-safety-of-an-abacavir-lamivudine%C3%A2-%C3%A2-rilpivirine-regimen-for-the-treatment-of-hiv-1-infection-in-naive-patients
#11
Adrian Curran, Jhon Rojas, Alfonso Cabello, Jesús Troya, Arkaitz Imaz, Pere Domingo, Esteban Martinez, Pablo Ryan, Miguel Górgolas, Daniel Podzamczer, Hernando Knobel, Félix Gutiérrez, Esteban Ribera
OBJECTIVES: To describe the effectiveness and safety of an abacavir/lamivudine + rilpivirine regimen in naive HIV-1-infected patients, as there is a lack of data with this combination. METHODS: This was an observational, retrospective, multicentre study in eight Spanish hospitals. All antiretroviral-naive patients ≥18 years old and starting abacavir/lamivudine + rilpivirine were included. Effectiveness (ITT and on-treatment) and safety (adverse events and laboratory parameters) were assessed during follow-up...
September 2, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27579612/dyslipidemias-and-elevated-cardiovascular-risk-on-lopinavir-based-antiretroviral-therapy-in-cambodia
#12
Setha Limsreng, Olivier Marcy, Sowath Ly, Vara Ouk, Hak Chanroeurn, Saem Thavary, Ban Boroath, Ana Canestri, Gérald Viretto, Jean-François Delfraissy, Olivier Ségéral
BACKGROUND: Lopinavir/ritonavir (LPV/r) is widely used in Cambodia with high efficacy but scarce data exist on long-term metabolic toxicity. METHODS: We carried out a cross-sectional and retrospective study evaluating metabolic disorders and cardiovascular risk in Cambodian patients on LPV/r-based antiretroviral therapy (ART) for > 1 year followed in Calmette Hospital, Phnom Penh. Data collected included cardiovascular risk factors, fasting blood lipids and glucose, and retrospective collection of bioclinical data...
2016: PloS One
https://www.readbyqxmd.com/read/27570910/association-of-dyslipidemia-and-glucose-abnormalities-with-antiretroviral-treatment-in-a-cohort-of-hiv-infected-latin-american-children
#13
Machline Paim Paganella, Rachel A Cohen, D Robert Harris, Ricardo de Souza Kuchenbecker, Rosa Dea Sperhacke, Sergio Kakuta Kato, Carmem Lúcia Oliveira da Silva, Fernanda Tomé Sturzbecher, Ricardo Hugo S Oliveira, Noris Pavía-Ruz, Rohan Hazra
OBJECTIVE(S): To estimate the incidence of lipid and glucose abnormalities and assess their association with exposure to antiretroviral (ARV) regimens among perinatally HIV-infected Latin American children. DESIGN: Longitudinal cohort study. METHODS: Data were analyzed from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) International Site Development Initiative (NISDI) Pediatric Latin American Countries Epidemiologic Study (PLACES)...
August 25, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27563366/exploratory-analysis-for-the-evaluation-of-estimated-glomerular-filtration-rate-cholesterol-and-triglycerides-after-switching-from-tenofovir-emtricitabine-plus-atazanavir-ritonavir-atv-r-to-abacavir-lamivudine-plus-atv-r-in-patients-with-preserved-renal-function
#14
Maria Concetta Postorino, Eugenia Quiros-Roldan, Franco Maggiolo, Simona Di Giambenedetto, Nicoletta Ladisa, Giuseppe Lapadula, Silvia Lorenzotti, Laura Sighinolfi, Filippo Castelnuovo, Massimo Di Pietro, Daria Gotti, Nicola Mazzini, Carlo Torti
BACKGROUND AND OBJECTIVES: Renal toxicity due to tenofovir (TDF) has been largely described in patients with HIV infection. However, other antiretroviral drugs (such as atazanavir [ATV], especially when boosted by ritonavir, ATV/r) could perpetuate some degrees of renal impairment with or without TDF co-administration. Also, possible benefits of stopping TDF in patients without renal diseases is not well known. This study aimed at exploring evolution of renal function and lipid profile after switching from tenofovir/emtricitabine (TDF/FTC) to abacavir/lamivudine (ABC/3TC), maintaining the ATV/r component of the regimen...
2016: Open AIDS Journal
https://www.readbyqxmd.com/read/27535019/ischaemic-stroke-in-hiv-infected-patients-a-case-control-study
#15
A Silva-Pinto, A Costa, R Serrão, A Sarmento, P Abreu
OBJECTIVES: The aim of the study was to provide insights into the contributions of HIV infection stage, antiretroviral therapy (ART) and vascular risk factors to the occurrence of ischaemic stroke in HIV-infected patients. METHODS: We performed a case-control study of HIV-infected patients followed in our clinic. We compared patients hospitalized between January 2006 and June 2014 with an ischaemic stroke or transient ischaemic attack to age- and gender-matched controls without stroke...
August 18, 2016: HIV Medicine
https://www.readbyqxmd.com/read/27490640/statin-drugs-decrease-progression-to-cirrhosis-in-hiv-hcv-co-infected-individuals
#16
Nora T Oliver, Christine M Hartman, Jennifer R Kramer, Elizabeth Y Chiao
INTRODUCTION: Chronic HIV/HCV co-infection carries increased risk of cirrhosis, hepatocellular carcinoma, and death. Due to anti-inflammatory properties, HMG co-A inhibitors (statins) may be useful adjunctive therapy to reduce liver disease progression. METHODS: Clinical information was extracted from the Veterans Affairs HIV and HCV Clinical Case Registries (1999 - 2010). HIV-related variables included combination anti-retroviral therapy (cART) era of diagnosis, CD4 cell count, and percent time with undetectable HIV viral load...
August 3, 2016: AIDS
https://www.readbyqxmd.com/read/27448678/lipid-profiles-and-apoe4-allele-impact-midlife-cognitive-decline-in-hiv-infected-men-on-antiretroviral-therapy
#17
Shibani S Mukerji, Joseph J Locascio, Vikas Misra, David R Lorenz, Alex Holman, Anupriya Dutta, Sudhir Penugonda, Steven M Wolinsky, Dana Gabuzda
BACKGROUND: Dyslipidemia and apolipoprotein E4 (APOE ϵ4) allele are risk factors for age-related cognitive decline, but how these risks are modified by human immunodeficiency virus (HIV) infection is unclear. METHODS: In a longitudinal nested study from the Multicenter AIDS Cohort Study, 273 HIV type 1-infected (HIV(+)) men aged 50-65 years with baseline HIV RNA <400 copies/mL and on continuous antiretroviral therapy (ART) in ≥95% of follow-up visits were matched by sociodemographic variables to 516 HIV-uninfected (HIV(-)) controls...
October 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27391355/hiv-infection-is-not-associated-with-carotid-intima-media-thickness-in-brazil-a-cross-sectional-analysis-from-the-ini-elsa-brasil-study
#18
Antonio G Pacheco, Beatriz Grinsztejn, Maria de Jesus M da Fonseca, Rosane Härter Griep, Paulo Lotufo, Isabela Bensenor, José G Mill, Rodrigo de C Moreira, Ronaldo I Moreira, Ruth K Friedman, Marilia Santini-Oliveira, Sandra W Cardoso, Valdiléa G Veloso, Dóra Chor
BACKGROUND: Carotid intima-media thickness (cIMT) has been used as an early marker of atherosclerotic disease in the general population. Recently its role among HIV-infected patients has been questioned. To date, no Brazilian study has compared cIMT in respect to HIV status. METHODS: We compared data from 535 patients actively followed in a prospective cohort in Rio de Janeiro (HIV group); 88 HIV-negative individuals who were nominated by patients (friend controls-FCs); and 10,943 participants of the ELSA-Brasil study...
2016: PloS One
https://www.readbyqxmd.com/read/27378623/effects-of-antiretroviral-treatment-on-paraoxonase-1-pon1-activity-in-rats
#19
Jolanta Elżbieta Pastryk, Marta Rusek, Jerzy Bełtowski
Highly active antiretroviral therapy (HAART), especially protease inhibitors (PIs), commonly used in HIV-infected patients, effectively suppresses a viral replication. However, it is frequently associated with significant side effects, including fat redistribution, lipodystrophy, hyperlipidemia, insulin resistance and diabetes mellitus. Currently, metabolic complications and atherosclerosis resulting from them become the major cause of mortality in HIV-infected patients receiving HAART. Paraoxonase 1 (PON1) is the HDL-bound esterase, which inhibits development of atherosclerosis by decomposing lipid peroxidation products and hydrolyzing homocysteine thiolactone...
November 25, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27355513/plasma-cxcl10-scd163-and-scd14-levels-have-distinct-associations-with-antiretroviral-treatment-and-cardiovascular-disease-risk-factors
#20
Alison Castley, Leah Williams, Ian James, George Guelfi, Cassandra Berry, David Nolan
We investigate the associations of three established plasma biomarkers in the context of HIV and treatment-related variables including a comprehensive cardiovascular disease risk assessment, within a large ambulatory HIV cohort. Patients were recruited in 2010 to form the Royal Perth Hospital HIV/CVD risk cohort. Plasma sCD14, sCD163 and CXCL10 levels were measured in 475 consecutive patients with documented CVD risk (age, ethnicity, gender, smoking, blood pressure, BMI, fasting metabolic profile) and HIV treatment history including immunological/virological outcomes...
2016: PloS One
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