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Pectus excavatum

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https://www.readbyqxmd.com/read/29672193/cryoanalgesia-in-patients-undergoing-nuss-repair-of-pectus-excavatum-technique-modification-and-early-results
#1
Nicole Morikawa, Nicole Laferriere, Sylvia Koo, Sidney Johnson, Russell Woo, Devin Puapong
PURPOSE: The Nuss procedure for surgical correction of pectus excavatum often causes severe postoperative pain. Cryoanalgesia of intercostal nerves is an alternative modality for pain control. We describe our modification of the cryoICE™ probe that allows for nerve ablation through the ipsilateral chest along with early results utilizing this technique. METHODS: To allow for ipsilateral nerve ablation, a 20-French chest tube was cut and secured to the cryoICE probe, thus providing insulation for the malleable end of the probe...
April 19, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29643965/video-assisted-thoracoscopic-surgery-in-left-to-right-nuss-procedure-for-pectus-excavatum-for-prevention-of-serious-complications-technical-aspects-based-on-1006-patients
#2
Krystian Pawlak, Łukasz Gąsiorowski, Piotr Gabryel, Wojciech Dyszkiewicz
Introduction: Additional use of the video-assisted thoracoscopic surgery (VATS) technique in the Nuss procedure has been globally accepted for the improvement of safety of surgical treatment as well as for decreased frequency of serious intraoperative and postoperative complications. Aim: To evaluate VATS in surgical treatment of patients with pectus excavatum by the left-to-right Nuss procedure for prevention of serious intra- and postoperative complications. Material and methods: From 2002 to 2016, 1006 patients with pectus excavatum aged 7 to 62 years (mean: 18...
March 2018: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/29629541/clinical-and-pathologic-findings-of-korean-patients-with-ryr1-related-congenital-myopathy
#3
Ha Neul Jeong, Hyung Jun Park, Jung Hwan Lee, Ha Young Shin, Se Hoon Kim, Seung Min Kim, Young Chul Choi
BACKGROUND AND PURPOSE: This study was designed to investigate clinical and pathologic characteristics of five Korean patients with RYR1-related congenital myopathy (CM). METHODS: Five patients from unrelated families were diagnosed with RYR1-related CM via direct or targeted sequencing of RYR1. Their clinical, mutational, and pathologic findings were then analyzed. RESULTS: Seven different mutations were identified, including two novel mutations: c...
January 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29617978/pectus-excavatum-causing-dynamic-right-ventricular-outflow-tract-obstruction-increased-obstruction-during-expiration-and-decreased-during-inspiration
#4
Dhaval Desai, M Fuad Jan, Renuka Jain, Farouk Mookadam, A Jamil Tajik
No abstract text is available yet for this article.
March 30, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29608431/postoperative-pain-outcomes-after-nuss-procedures-comparison-of-epidural-analgesia-continuous-infusion-of-local-anesthetic-and-preoperative-self-hypnosis-training
#5
Renee C B Manworren, Matthew N Anderson, Eric D Girard, Kimberly A Ruscher, Ana Maria Verissimo, Hannah Palac, Richard Weiss, Christine Rader, Donald Hight
BACKGROUND/PURPOSE: The Nuss procedure to correct pectus excavatum is associated with severe postoperative pain. The purpose of this retrospective study was to compare pain management outcomes of thoracic epidural analgesia and continuous infusion of local anesthetic (CILA) with and without preoperative self-hypnosis training (SHT) after Nuss procedure (4 treatment groups). METHODS: Between February 2010 and December 2013, 24 of 53 adolescents who underwent Nuss procedure received SHT...
April 2, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29607200/initial-experience-with-a-3d-printed-model-for-preoperative-simulation-of-the-nuss-procedure-for-pectus-excavatum
#6
Naoto Matsuo, Keitaro Matsumoto, Yasuaki Taura, Yuka Sakakibara, Daisuke Taniguchi, Katsunori Takagi, Yusuke Yamane, Masayuki Obatake, Naoya Yamasaki, Takeshi Nagayasu
The incidence of pectus excavatum has been estimated to be between 0.1% and 0.8% though a large autopsy series reports. After publication of the Nuss procedure for pectus excavatum, it became widely accepted. However, there are still some complications, such as over-correction and recurrence. To reduce differences in the procedure due to surgeons' experience level, preoperative simulation may be useful. Thus, we performed simulated surgery using a specific patient's three-dimensional (3D) chest wall model made by a 3D printer before operation...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29606411/nonoperative-management-of-pectus-excavatum-with-vacuum-bell-therapy-a-single-center-study
#7
Robert J Obermeyer, Nina S Cohen, Robert E Kelly, M Ann Kuhn, Frazier W Frantz, Margaret M McGuire, James F Paulson
PURPOSE: The purpose of this study was to determine variables predictive of an excellent correction using vacuum bell therapy for nonoperative treatment of pectus excavatum. METHODS: A single institution, retrospective evaluation (IRB 15-01-WC-0024) of variables associated with an excellent outcome in pectus excavatum patients treated with vacuum bell therapy was performed. An excellent correction was defined as a chest wall depth equal to the mean depth of a reference group of 30 male children without pectus excavatum...
March 8, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29602550/minimally-invasive-repair-of-pectus-excavatum-analysis-of-the-nsqip-database-and-the-use-of-thoracoscopy
#8
Oswald Tetteh, Daniel S Rhee, Emily Boss, Samuel M Alaish, Alejandro V Garcia
BACKGROUND: The minimally invasive repair of pectus excavatum (MIRPE) has been widely accepted and has become a viable alternative to the open Ravitch technique. MIRPE has evolved over time with some advocating that a safe repair can be accomplished without direct visualization utilizing thoracoscopy. The MIRPE with and without a thoracoscopic approach has not been previously analyzed from a nationwide database to determine differences in safety and short-term outcomes. METHODS: The American College of Surgeons National Surgical Quality Improvement Program-Pediatric (NSQIP-P) 2012-2015 database was used in identifying patients that had MIRPE using Current Procedural Terminology (CPT) codes and ICD-9CM/ICD-10CM postoperative diagnosis codes...
March 7, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29599822/novel-phenotype-of-5p13-3-q11-2-duplication-resulting-from-supernumerary-marker-chromosome-5-implications-for-management-and-genetic-counseling
#9
Margaret E Armstrong, David D Weaver, Melissa D Lah, Gail H Vance, Benjamin J Landis, Stephanie M Ware, Benjamin M Helm
Background: Supernumerary marker chromosomes derived from chromosome 5 (SMC5) and 5p13 duplication syndrome are rare disorders, and phenotypic descriptions of patients are necessary to better define genotype-phenotype correlations for accurate, comprehensive genetic counseling. The purpose of this study is to highlight the unique findings of a patient with a 5p13.3-q11.2 duplication arising from a SMC5 and compare and contrast the phenotype with cases in the literature. Case presentation: We report on an adult male with a 22 Mb duplication of chromosome 5p13...
2018: Molecular Cytogenetics
https://www.readbyqxmd.com/read/29593167/correlation-between-clinical-severity-and-type-and-degree-of-pectus-excavatum-in-twelve-brachycephalic-dogs
#10
Elham A Hassan, Marwa H Hassan, Faisal A Torad
The aim of the study was to correlate the clinical severity of pectus excavatum with its type and degree based on objective radiographic evaluation. Twelve brachycephalic dogs were included. Grading of the clinical severity was done based on a 6-point grading score. Thoracic radiographs were used to calculate the frontosagittal and vertebral indices at the tenth thoracic vertebra and the vertebra overlying the excavatum. Correlation between the clinical severity score and frontosagittal and vertebral indices was evaluated using Pearson's correlation coefficient...
March 29, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29550038/changes-in-resting-pulmonary-function-testing-over-time-after-the-nuss-procedure-a-systematic-review-and-meta-analysis
#11
REVIEW
Quan Wang, Shulei Fan, Chun Wu, Xianqing Jin, Zhengxia Pan, Daqing Hong
BACKGROUND: Pectus excavatum, the most common congenital chest wall deformity in pediatric patients, leads to pulmonary dysfunction. There is no consensus regarding the effectiveness of the Nuss procedure for recovering pulmonary function. In this meta- analysis, we focused on the changes that occur in pulmonary function after the Nuss procedure. METHODS: We performed a literature search in the MEDLINE, Embase, Cochrane library and PubMed databases. The included studies were required to contain pulmonary function tests with results adjusted to predicted values both before and after the Nuss procedure...
February 21, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29549009/a-novel-objective-approach-to-the-external-measurement-of-pectus-excavatum-severity-by-means-of-an-optical-device
#12
Francesca Uccheddu, Marco Ghionzoli, Yary Volpe, Michaela Servi, Rocco Furferi, Lapo Governi, Flavio Facchini, Roberto Lo Piccolo, Kathleen S McGreevy, Alessandra Martin, Monica Carfagni, Antonio Messineo
BACKGROUND: Current approaches to quantifying the severity of pectus excavatum (PE) require internal measurements based on cross-sectional imaging. The aim of this study is to exploit a novel index evaluated on the external surface of the chest with a 3D optical scanner. METHODS: 51 children (41 males, 10 females), between 2 and 17 years old, were evaluated with a 3D optical scanner. PE severity was calculated by using an ad hoc instant 3D scanner and defining an automatic procedure to generate an optical 3D index (CI-3D)...
March 13, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29525894/surgical-correction-of-pectus-excavatum-by-the-nuss-procedure-a-15-year-experience-study
#13
Piotr Cierpikowski, Adam Rzechonek, Piotr Błasiak, Hanna Lisowska, Grzegorz Pniewski, Patric Le Pivert
Pectus excavatum is the most common congenital deformity of the chest. The Nuss procedure is minimally invasive surgical correction of this defect, using retrosternal metal bars. The purpose of the present study was to describe a 15-year experience with the Nuss surgery, and to evaluate the long-term clinical results of the procedure. We retrospectively evaluated 239 patients, aged 14-34, who underwent the Nuss surgery in the years 2002-2016. Postoperative complications were observed in 40/236 (16.9%) patients...
March 11, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29514872/homozygous-chst11-mutation-in-chondrodysplasia-brachydactyly-overriding-digits-clino-symphalangism-and-synpolydactyly
#14
Rana Muhammad Kamran Shabbir, Gökhan Nalbant, Nafees Ahmad, Sajid Malik, Aslıhan Tolun
BACKGROUND: Carbohydrate sulfotransferase 11 (CHST11) is a membrane protein of Golgi that catalyses the transfer of sulfate to position 4 of the N-acetylgalactosamine residues of chondroitin. Chondroitin sulfate is the predominant proteoglycan in cartilage, and its sulfation is important in the developing growth plate of cartilage. A homozygous deletion encompassing part of the gene and the embedded miRNA MIR3922 had been detected in a woman with hand/foot malformation and malignant lymphoproliferative disease...
March 7, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29506132/beyond-aesthetic-consequences-congestive-hepatopathy-caused-by-pectus-excavatum
#15
Robin Baudouin, Eric Levesque, René Jancovici
Pectus excavatum can lead to right ventricle compression. Although extremely rare, congestive hepatopathy should be considered when patients with severe pectus excavatum present with cardiovascular involvement.
March 1, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29500788/pigeon-chest-comparative-analysis-of-surgical-techniques-in-minimal-access-repair-of-pectus-carinatum-marpc
#16
REVIEW
Ancuta Muntean, Ionica Stoica, Amulya K Saxena
BACKGROUND: After minimally invasive repair for pectus excavatum (MIRPE), similar procedures for pectus carinatum were developed. This study aimed to analyse the various published techniques of minimal access repair for pectus carinatum (MARPC) and compare the outcomes. DATA SOURCES: Literature was reviewed on PubMed with the terms "pectus carinatum", "minimal access repair", "thoracoscopy" and "children". RESULTS: Twelve MARPC techniques that included 13 articles and 140 patients with mean age 15...
February 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29473012/nuss-procedure-for-a-patient-with-negative-haller-index
#17
Mariela Dore, Paloma Triana Junco, Carlos De La Torre, Alejandra Vilanova-Sánchez, Monserrat Bret, Gaspar Gonzalez, Vanesa Nuñez Cerezo, Javier Jimenez Gomez, Jose Luis Encinas, Francisco Hernandez, Leopoldo Martínez Martínez, Manuel Lopez Santamaria
Introduction  Minimally invasive repair for pectus excavatum (MIRPE) is controversial in extremely severe cases of pectus excavatum (PE) and an open repair is usually favored. Our aim is to describe a case of a patient with an extremely severe PE that underwent a minimally invasive approach. Case report  An 8-year-old girl with severe sternum depression was assessed. She had a history of exercise intolerance, nocturnal dyspnea, fatigue, and shortness of breath. Chest computed tomography showed that sternum depression was posterior to the anterior vertebral column; therefore, Haller and correction index could not be measured...
January 2018: European Journal of Pediatric Surgery Reports
https://www.readbyqxmd.com/read/29460436/truncating-variants-of-the-dlg4-gene-are-responsible-for-intellectual-disability-with-marfanoid-features
#18
M Sébastien, B Ange-Line, A Mirna, C Martin, S Elisabeth, G Cyril, G Anne-Marie, C Aude, C Perrine, H Delphine, F Anne, H Nada, V Antonio, T-M-T Frédéric, P Christophe, D Yannis, T-R Christel, F Laurence
Marfanoid habitus (MH) combined with intellectual disability (ID) is a genetically and clinically heterogeneous group of overlapping disorders. We performed exome sequencing in 33 trios and 31 single probands to identify novel genes specific to MH-ID. After the search for variants in OMIM genes and non-OMIM genes with classical approaches, we searched for variants in non-disease-causing genes whose pLI was above 0.9 (ExAC Consortium data), in which truncating variants were found in at least 3 unrelated patients, in order to identity novel MH-ID genes...
February 20, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29430201/outcomes-in-adult-pectus-excavatum-patients-undergoing-nuss-repair
#19
REVIEW
MennatAllah M Ewais, Shivani Chaparala, Rebecca Uhl, Dawn E Jaroszewski
Pectus excavatum (PEx) is one of the most common congenital chest wall deformities. Depending on the severity, presentation of PEx may range from minor cosmetic issues to disabling cardiopulmonary symptoms. The effect of PEx on adult patients has not been extensively studied. Symptoms may not occur until the patient ages, and they may worsen over the years. More recent publications have implied that PEx may have significant cardiopulmonary implications and repair is of medical benefit. Adults presenting for PEx repair can undergo a successful repair with a minimally invasive "Nuss" approach...
2018: Patient related Outcome Measures
https://www.readbyqxmd.com/read/29411068/early-consequences-of-pectus-excavatum-surgery-on-self-esteem-and-general-quality-of-life
#20
W P Zuidema, J W A Oosterhuis, G W Zijp, S M van der Heide, A F W van der Steeg, L W E van Heurn
BACKGROUND: An early observation after chest wall correction is direct inspection from the PE patient of their "new" thorax. Changes in self-perception may give raise to other psychological adaptations. The aim of this study was to evaluate the early changes in the fields of self-esteem, body image and QoL. METHODS: Prospective observational longitudinal multicenter cohort study. Self-esteem, emotional limitations and general health were assessed using the Child Health Questionnaire (CHQ) in patients under 18 and the World Health Organization Quality of Life Questionnaire-bref (WHOQOL-bref) was used for body image, psychological domain and overall QoL in patients over 16 years of age...
February 6, 2018: World Journal of Surgery
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