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Rectal MRI

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https://www.readbyqxmd.com/read/28937269/dose-escalation-using-contact-x-ray-brachytherapy-papillon-for-rectal-cancer-does-it-improve-the-chance-of-organ-preservation
#1
Arthur Sun Myint, Fraser McLean Smith, Simon William Gollins, Helen Wong, Christopher Rao, Karen Whitmarsh, Raj Sripadam, Paul Rooney, Michael Jeremy Hershman, Zsolt Fekete, Kate Perkins, D Mark Pritchard
OBJECTIVE: A watch and wait policy for patients with a complete clinical response (cCR) after external beam chemoradiotherapy (EBCRT) for rectal cancer is an attractive option. However, approximately a third of tumours will regrow, which requires surgical salvage for cure. We assessed whether contact x-ray brachytherapy (CXB) can improve organ preservation by avoiding surgery for local regrowth. METHODS: From our institutional database, we identified 200 of 573 patients treated by CXB from 2003 to 2012...
September 20, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28934761/comparison-between-mri-and-pathology-in-the-assessment-of-tumour-regression-grade-in-rectal-cancer
#2
Francesco Sclafani, Gina Brown, David Cunningham, Andrew Wotherspoon, Larissa Sena Teixeira Mendes, Svetlana Balyasnikova, Jessica Evans, Clare Peckitt, Ruwaida Begum, Diana Tait, Josep Tabernero, Bengt Glimelius, Susana Roselló, Janet Thomas, Jacqui Oates, Ian Chau
BACKGROUND: Limited data exist regarding the correlation between MRI tumour regression grade (mrTRG) and pathological TRG (pTRG) in rectal cancer. METHODS: mrTRG and pTRG were compared in rectal cancer patients from two phase II trials (EXPERT and EXPERT-C). The agreement between radiologist and pathologist was assessed with the weighted κ test while the Kaplan-Meier method was used to estimate survival outcomes. RESULTS: One hundred ninety-one patients were included...
September 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28933973/magnetic-resonance-imaging-in-the-early-detection-of-prostate-cancer-and-review-of-the-literature-on-magnetic-resonance-imaging-stratified-clinical-pathways
#3
Taimur Tariq Shah, Wilson King Lim To, Hashim Uddin Ahmed
With level 1 evidence now available on the diagnostic accuracy of multiparametric magnetic resonance imaging (MRI) we must now utilise this data in developing an MRI-stratified diagnostic pathway for the early detection of prostate cancer. Areas covered: A literature review was conducted and identified seven randomised control trials (RCT's) assessing the diagnostic accuracy of such a pathway against the previously accepted systematic/random trans-rectal ultrasound guided (TRUS) biopsy pathway. The studies were heterogeneous in their design...
September 21, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28931946/comparison-of-perfusion-models-for-quantitative-t1-weighted-dce-mri-of-rectal-cancer
#4
Tanja Gaa, Wiebke Neumann, Sonja Sudarski, Ulrike I Attenberger, Stefan O Schönberg, Lothar R Schad, Frank G Zöllner
In this work, the two compartment exchange model and two compartment uptake model were applied to obtain quantitative perfusion parameters in rectum carcinoma and the results were compared to those obtained by the deconvolution algorithm. Eighteen patients with newly diagnosed rectal carcinoma underwent 3 T MRI of the pelvis including a T1 weighted dynamic contrastenhanced (DCE) protocol before treatment. Mean values for Plasma Flow (PF), Plasma Volume (PV) and Mean Transit Time (MTT) were obtained for all three approaches and visualized in parameter cards...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28929282/anoperineal-lesions-in-crohn-s-disease-french-recommendations-for-clinical-practice
#5
REVIEW
D Bouchard, L Abramowitz, G Bouguen, C Brochard, A Dabadie, V de Parades, M Eléouet-Kaplan, N Fathallah, J-L Faucheron, L Maggiori, Y Panis, F Pigot, P Rouméguère, A Sénéjoux, L Siproudhis, G Staumont, J-M Suduca, B Vinson-Bonnet, J-D Zeitoun
BACKGROUND: Anoperineal lesion (APL) occurrence is a significant event in the evolution of Crohn's disease (CD). Management should involve a multidisciplinary approach combining the knowledge of the gastroenterologist, the colorectal surgeon and the radiologist who have appropriate experience in this area. Given the low level of evidence of available medical and surgical strategies, the aim of this work was to establish a French expert consensus on management of anal Crohn's disease. These recommendations were led under the aegis of the Société Nationale Française de Colo-Proctologie (SNFCP)...
September 19, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28924962/the-impact-of-tumour-distance-from-the-anal-verge-on-clinical-management-and-outcomes-in-patients-having-a-curative-resection-for-rectal-cancer
#6
Muhammad Amir Saeed Khan, Chin W Ang, Abdul Rahman Hakeem, Nigel Scott, Rick Nigel Saunders, Ian Botterill
AIM: The clinico-oncological significance of the distance of rectal cancer from the anal verge is unclear and not well reported. The aim of this study is to assess the influence of the rectal cancer distance from the anal verge on clinical management and long-term outcomes after curative resection in a specialised colorectal cancer unit. METHODS: Prospectively collected data on patients who underwent primary rectal cancer treatment at our unit between January 2005 and December 2010 were analysed...
September 18, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28905134/postmortem-mr-diffusion-weighted-imaging-of-the-liver-time-behavior-of-the-hepatic-apparent-diffusion-coefficient-in-the-early-death-interval
#7
Sarah Keller, Tony M Schmidt, Anne Catherine Kim, Roland Fischer, Axel Heinemann, Gerhard Adam, Jin Yamamura
OBJECTIVE: The objective of this study is to assess postmortem changes of the hepatic apparent diffusion coefficient (ADC) at multiple time points in the time interval of 16 hours postmortem in comparison to in vivo controls and to literature data. MATERIAL AND METHODS: Hepatic diffusion-weighted imaging (DWI) was repeatedly performed at 1.5 Tesla (b values 50, 400, and 800 s/mm(2)) in 2-hourly steps within 16 hours postmortem in 19 cases (male to female 13:6, mean age 68...
September 14, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28900855/accuracy-of-various-lymph-node-staging-criteria-in-rectal-cancer-with-magnetic-resonance-imaging
#8
Jörn Gröne, Florian N Loch, Matthias Taupitz, C Schmidt, Martin E Kreis
INTRODUCTION: The accuracy of pretherapeutic staging of lymph nodes (LN) in rectal cancer by MR imaging (MRI) is still limited. The aim of the study was to determine the sensitivity and specificity of different morphological criteria in nodal staging. MATERIAL AND METHODS: LN were analyzed by MRI in 60 patients with rectal cancer and primary surgery. Signs of LN metastasis (cN+) were spiculated/indistinct border contour, inhomogeneous signal intensity, or LN size...
September 12, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28863161/diffusion-weighted-imaging-in-patients-with-rectal-cancer-comparison-between-gaussian-and-non-gaussian-models
#9
Georgios C Manikis, Kostas Marias, Doenja M J Lambregts, Katerina Nikiforaki, Miriam M van Heeswijk, Frans C H Bakers, Regina G H Beets-Tan, Nikolaos Papanikolaou
PURPOSE: The purpose of this study was to compare the performance of four diffusion models, including mono and bi-exponential both Gaussian and non-Gaussian models, in diffusion weighted imaging of rectal cancer. MATERIAL AND METHODS: Nineteen patients with rectal adenocarcinoma underwent MRI examination of the rectum before chemoradiation therapy including a 7 b-value diffusion sequence (0, 25, 50, 100, 500, 1000 and 2000 s/mm2) at a 1.5T scanner. Four different diffusion models including mono- and bi-exponential Gaussian (MG and BG) and non-Gaussian (MNG and BNG) were applied on whole tumor volumes of interest...
2017: PloS One
https://www.readbyqxmd.com/read/28862352/geometric-distortion-correction-in-prostate-diffusion-weighted-mri-and-its-effect-on-quantitative-apparent-diffusion-coefficient-analysis
#10
Gabriel Nketiah, Kirsten M Selnaes, Elise Sandsmark, Jose R Teruel, Brage Krüger-Stokke, Helena Bertilsson, Tone F Bathen, Mattijs Elschot
PURPOSE: To evaluate the effect of correction for B0 inhomogeneity-induced geometric distortion in echo-planar diffusion-weighted imaging on quantitative apparent diffusion coefficient (ADC) analysis in multiparametric prostate MRI. METHODS: Geometric distortion correction was performed in echo-planar diffusion-weighted images (b = 0, 50, 400, 800 s/mm(2) ) of 28 patients, using two B0 scans with opposing phase-encoding polarities. Histology-matched tumor and healthy tissue volumes of interest delineated on T2 -weighted images were mapped to the nondistortion-corrected and distortion-corrected data sets by resampling with and without spatial coregistration...
September 1, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28859058/preoperative-chemoradiation-with-capecitabine-irinotecan-and-cetuximab-in-rectal-cancer-significance-of-pre-treatment-and-post-resection-ras-mutations
#11
Simon Gollins, Nick West, David Sebag-Montefiore, Arthur Sun Myint, Mark Saunders, Shabbir Susnerwala, Phil Quirke, Sharadah Essapen, Leslie Samuel, Bruce Sizer, Jane Worlding, Katie Southward, Gemma Hemmings, Emma Tinkler-Hundal, Morag Taylor, Daniel Bottomley, Philip Chambers, Emma Lawrie, Andre Lopes, Sandy Beare
BACKGROUND: The influence of EGFR pathway mutations on cetuximab-containing rectal cancer preoperative chemoradiation (CRT) is uncertain. METHODS: In a prospective phase II trial (EXCITE), patients with magnetic resonance imaging (MRI)-defined non-metastatic rectal adenocarinoma threatening/involving the surgical resection plane received pelvic radiotherapy with concurrent capecitabine, irinotecan and cetuximab. Resection was recommended 8 weeks later. The primary endpoint was histopathologically clear (R0) resection margin...
August 31, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28858036/altered-regional-homogeneity-in-patients-with-late-monocular-blindness-a-resting-state-functional-mri-study
#12
Xin Huang, Cheng-Long Ye, Yu-Lin Zhong, Lei Ye, Qi-Chen Yang, Hai-Jun Li, Nan Jiang, De-Chang Peng, Yi Shao
Many previous studies have demonstrated that the blindness patients have has functional and anatomical abnormalities in the visual and other vision-related cortex. However, changes in the brain function in late monocular blindness (MB) at rest are largely unknown. In this study, we investigated the underlying regional homogeneity (ReHo) of brain-activity abnormalities in patients with late MB and their relationship with clinical features. A total of 32 patients with MB (25 male and seven female) and 32 healthy controls (HCs) (25 male and seven female) closely matched in age, sex, and education underwent resting-state functional MRI scans...
August 28, 2017: Neuroreport
https://www.readbyqxmd.com/read/28853678/hpv-related-squamous-cell-carcinoma-in-a-neovagina-after-male-to-female-gender-confirmation-surgery
#13
Jesús Bollo, Andrea Balla, Carlos Rodriguez Luppi, Carmen Martinez, Silvia Quaresima, Eduard M Targarona
Vaginoplasty by penile and scrotal skin inversion is a well-established technique for male-to-female gender confirmation surgery. In this setting, chronic inflammation and lacerations associated with history of human papillomavirus (HPV) infection may induce a high risk of malignant degeneration in the long term. A 78-year-old transgender woman was admitted with genital discomfort and neovaginal discharge. The patient's history revealed male-to-female gender confirmation surgery with construction of a neovagina by penile and scrotal skin inversion at 33 years of age...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28853167/a-urinary-biomarker-based-risk-score-correlates-with-multiparametric-mri-for-prostate-cancer-detection
#14
Rianne J Hendriks, Marloes M G van der Leest, Siebren Dijkstra, Jelle O Barentsz, Wim Van Criekinge, Christina A Hulsbergen-van de Kaa, Jack A Schalken, Peter F A Mulders, Inge M van Oort
BACKGROUND: Prostate cancer (PCa) diagnostics would greatly benefit from more accurate, non-invasive techniques for the detection of clinically significant disease, leading to a reduction of over-diagnosis and over-treatment. The aim of this study was to determine the association between a novel urinary biomarker-based risk score (SelectMDx), multiparametric MRI (mpMRI) outcomes, and biopsy results for PCa detection. METHODS: This retrospective observational study used data from the validation study of the SelectMDx score, in which urine was collected after digital rectal examination from men undergoing prostate biopsies...
August 29, 2017: Prostate
https://www.readbyqxmd.com/read/28851403/a-rectal-cancer-feasibility-study-with-an-embedded-phase-iii-trial-design-assessing-magnetic-resonance-tumour-regression-grade-mrtrg-as-a-novel-biomarker-to-stratify-management-by-good-and-poor-response-to-chemoradiotherapy-trigger-study-protocol-for-a-randomised
#15
Nick J Battersby, Mit Dattani, Sheela Rao, David Cunningham, Diana Tait, Richard Adams, Brendan J Moran, Shelize Khakoo, Paris Tekkis, Shahnawaz Rasheed, Alex Mirnezami, Philip Quirke, Nicholas P West, Iris Nagtegaal, Irene Chong, Anguraj Sadanandam, Nicola Valeri, Karen Thomas, Michelle Frost, Gina Brown
BACKGROUND: Pre-operative chemoradiotherapy (CRT) for MRI-defined, locally advanced rectal cancer is primarily intended to reduce local recurrence rates by downstaging tumours, enabling an improved likelihood of curative resection. However, in a subset of patients complete tumour regression occurs implying that no viable tumour is present within the surgical specimen. This raises the possibility that surgery may have been avoided. It is also recognised that response to CRT is a key determinant of prognosis...
August 29, 2017: Trials
https://www.readbyqxmd.com/read/28846947/transanal-total-mesorectal-excision-as-a-surgical-procedure-for-diffuse-cavernous-hemangioma-of-the-rectum-a-case-report
#16
Xian-Rui Wu, Wei-Wen Liang, Xing-Wei Zhang, Liang Kang, Ping Lan
BACKGROUND: The safety and feasibility of transanal total mesorectal excision (TaTME) were demonstrated in the management of rectal cancer. However, its role in the management of patients with diffuse cavernous hemangioma of the rectum (DCHR) has not been evaluated. METHODS: A female patient with DCHR was admitted to our hospital. Colonoscopy, magnetic resonance imaging (MRI), abdominal computed tomography (CT) and arteriography were performed. Lesions were detected in mesorectum and rectal wall extending from the dentate line to 5cm proximally...
August 10, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28836241/-standardized-development-of-transanal-endoscopic-microsurgery
#17
Guole Lin
Transanal endoscopic microsurgery (TEM) is currently the only one-port system in endoscopic surgery, which a direct endoluminal approach can lead to the target organ through a natural opening of human body. TEM has been applied in colorectal surgery for over 3 decades. Compared with radical surgery, TEM has the advantages, such as quicker recovery, shorter hospital stay and fewer complications. One perfect TEM surgical system, which mainly consists of three parts, namely peculiar rectoscope for surgery, special surgical instruments and imaging system, is the foundation of standardized development of TEM...
August 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28803377/temporary-successful-results-of-ventral-rectopexy-for-enterocele-surgical-correction-about-138-patients
#18
Diane Mege, Arnaud Sans, Aurélie Maignan, Julie Duclos, Cécilia Frasconi, Remy Le Huu Nho, Nicolas Pirro, Igor Sielezneff
PURPOSE: This work aimed to analyse short- and long-term results of enterocele surgical treatment by ventral rectopexy. METHODS: All females who underwent ventral rectopexy for enterocele in our department were included. All patients underwent standardized preoperative evaluation. Data was retrospectively collected, after examination of patients or by telephone survey. Postoperative evaluation was performed by an independent observer. RESULTS: One hundred thirty-eight females (median age = 63 years [21-86 years]) were included...
August 12, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28802956/magnetic-resonance-imaging-compared-with-rectal-endoscopic-sonography-for-the-prediction-of-infiltration-depth-in-colorectal-endometriosis
#19
Arane Kim, Pedro Fernandez, Brigitte Martin, Laurent Palazzo, Lara Ribeiro-Parenti, Francine Walker, Margot Bucau, Dominique Luton, Carmen Chis, Martin Koskas
STUDY OBJECTIVE: To compare the accuracies of magnetic resonance imaging (MRI) and rectal endoscopic sonography (RES) in the prediction of the infiltration depth of colorectal endometriosis. DESIGN: Retrospective cohort study (Canadian Task Force classification II-2). SETTING: University teaching hospital. PATIENTS: Forty patients with symptomatic deep infiltrating endometriosis (DIE) of the rectum who underwent colorectal resection were included...
August 9, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28796760/acute-flaccid-myelitis-among-children-washington-september-november-2016
#20
Jesse Bonwitt, Amy Poel, Chas DeBolt, Elysia Gonzales, Adriana Lopez, Janell Routh, Krista Rietberg, Natalie Linton, James Reggin, James Sejvar, Scott Lindquist, Catherine Otten
In October 2016, Seattle Children's Hospital notified the Washington State Department of Health (DOH) and CDC of a cluster of acute onset of limb weakness in children aged ≤14 years. All patients had distinctive spinal lesions largely restricted to gray matter detected by magnetic resonance imaging (MRI), consistent with acute flaccid myelitis (AFM). On November 3, DOH issued a health advisory to local health jurisdictions requesting that health care providers report similar cases. By January 24, 2017, DOH and CDC had confirmed 10 cases of AFM and excluded two suspected cases among residents of Washington during September-November 2016...
August 11, 2017: MMWR. Morbidity and Mortality Weekly Report
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