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https://www.readbyqxmd.com/read/29204790/cytoplasmic-expression-of-twist1-an-emt-related-transcription-factor-is-associated-with-higher-grades-renal-cell-carcinomas-and-worse-progression-free-survival-in-clear-cell-renal-cell-carcinoma
#1
Arezoo Rasti, Zahra Madjd, Maryam Abolhasani, Mitra Mehrazma, Leila Janani, Leili Saeednejad Zanjani, Mojgan Asgari
Twist1 is a key transcription factor, which confers tumor cells with cancer stem cell (CSC)-like characteristics and enhances epithelial-mesenchymal transition in pathological conditions including tumor malignancy and metastasis. This study aimed to evaluate the expression patterns and clinical significance of Twist1 in renal cell carcinoma (RCC). The cytoplasmic and nuclear expression of Twist1 were examined in 252 well-defined renal tumor tissues, including 173 (68.7%) clear cell renal cell carcinomas (ccRCC), 45 (17...
December 4, 2017: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29110589/antimicrobial-peptides-of-marine-crustaceans-the-potential-and-challenges-of-developing-therapeutic-agents
#2
Negar Talaei Zanjani, Monica Miranda-Saksena, Anthony L Cunningham, Fariba Dehghani
The alarming increase of antimicrobial resistance has led to a fast growing body of studies aiming to develop novel antimicrobial therapeutics. Natural antimicrobial peptides possess a potent and broad-spectrum antimicrobial activity combined with diverse and unique structural motifs, which confer their different mechanisms of action. These peptides are ubiquitous in organisms and are integral to the innate immune system. Recently, identification of antimicrobial peptides from marine crustaceans has become the centre of attention of many researchers...
November 6, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29109399/competition-between-crystal-and-fibril-formation-in-molecular-mutations-of-amyloidogenic-peptides
#3
Nicholas P Reynolds, Jozef Adamcik, Joshua T Berryman, Stephan Handschin, Ali Asghar Hakami Zanjani, Wen Li, Kun Liu, Afang Zhang, Raffaele Mezzenga
Amyloidogenic model peptides are invaluable for investigating assembly mechanisms in disease related amyloids and in protein folding. During aggregation, such peptides can undergo bifurcation leading to fibrils or crystals, however the mechanisms of fibril-to-crystal conversion are unclear. We navigate herein the energy landscape of amyloidogenic peptides by studying a homologous series of hexapeptides found in animal, human and disease related proteins. We observe fibril-to-crystal conversion occurring within single aggregates via untwisting of twisted ribbon fibrils possessing saddle-like curvature and cross-sectional aspect ratios approaching unity...
November 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/29075348/physiochemical-properties-of-experimental-nano-hybrid-mta
#4
V Akhavan Zanjani, K Tabari, S M Sheikh-Al-Eslamian, A N Abrandabadi
Introduction: Development of new pulp capping agents has paved the way towards the preservation of pulp vitality, which is an important goal in restorative dentistry. This study sought to assess the calcium ion release, pH and setting of mineral trioxide aggregate (MTA) Angelus, an experimental formulation of nano-hybrid MTA containing nano-SiO2, nano-Al2O3 and nano-TiO2 and MTA Angelus plus nano-oxides. Methods: In this experimental study, five specimens from each material were placed in polypropylene tubes and immersed in a flask containing deionized distilled water...
July 2017: Journal of Medicine and Life
https://www.readbyqxmd.com/read/29050853/cytoplasmic-expression-of-cd133-stemness-marker-is-associated-with-tumor-aggressiveness-in-clear-cell-renal-cell-carcinoma
#5
Leili Saeednejad Zanjani, Zahra Madjd, Maryam Abolhasani, Yvonne Andersson, Arezoo Rasti, Ahmad Shariftabrizi, Mojgan Asgari
Prominin-1 (CD133) is one of the most commonly used markers for cancer stem cells (CSCs), which are characterized by their ability for self-renewal and tumorigenicity. However, the clinical and prognostic significance of CSCs in renal cell carcinoma (RCC) remains unclear. The aim of this study was to investigate the expression patterns and prognostic significance of the cancer stem cell marker CD133 in different histological subtypes of RCC. CD133 expression was evaluated using immunohistochemistry in 193 well-defined renal tumor samples on tissue microarrays, including 136 (70...
October 16, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29038719/phenomenological-needs-assessment-of-parents-of-children-with-cochlear-implants
#6
Firoozeh Mostafavi, Seyed Mohammad Mahdi Hazavehei, Mohammad Majid Oryadi-Zanjani, Gholamreza Sharifi Rad, Abbas Rezaianzadeh, Leila Ravanyar
BACKGROUND: The use of cochlear implants has been a remarkable success in reducing disabilities in those with impaired hearing, which have made a significant change in the patients' quality of life. Only by relying on cochlear implants, disabilities cannot be eliminated in the hearing impaired, and, alongside this intervention, rehabilitation practices such as through family and community support are necessary. AIM: To explain the needs of parents of children with cochlear implants to increase the quality of rehabilitation services and family-based interventions...
September 2017: Electronic Physician
https://www.readbyqxmd.com/read/29037442/estimation-of-in-vivo-inter-vertebral-loading-during-motion-using-fluoroscopic-and-magnetic-resonance-image-informed-finite-element-models
#7
Sahand Zanjani-Pour, Judith R Meakin, Alex Breen, Alan Breen
Finite element (FE) models driven by medical image data can be used to estimate subject-specific spinal biomechanics. This study aimed to combine magnetic resonance (MR) imaging and quantitative fluoroscopy (QF) in subject-specific FE models of upright standing, flexion and extension. Supine MR images of the lumbar spine were acquired from healthy participants using a 0.5 T MR scanner. Nine 3D quasi-static linear FE models of L3 to L5 were created with an elastic nucleus and orthotropic annulus. QF data was acquired from the same participants who performed trunk flexion to 60° and trunk extension to 20°...
October 6, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29026507/face-and-content-validity-of-the-macarthur-competence-assessment-tool-for-the-treatment-of-iranian-patients
#8
Ali Saber, Seyed Mahmoud Tabatabaei, Godarz Akasheh, Mojtaba Sehat, Zahra Zanjani, Bagher Larijani
BACKGROUND: There is not a valid Persian tool for measuring the decision-making competency of patients. The aim of this study is to evaluate the face and content validity of the MacArthur Competence Assessment Tool for the treatment of Iranian Persian-speaking patients. METHODS: To assess the validity of the Persian version of the tool, a self-administrated questionnaire was designed. The Lawshe method was also used for assessing each item. Content validity ratio (CVR) and content validity index (CVI) were used to assess the content validity quantitatively...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29018830/antivenom-efficacy-in-neutralizing-histopathological-complications-following-latrodectus-dahli-envenomation
#9
Elham Valikhanfard-Zanjani, Abbas Zare-Mirakabadi, Ehsan Zayerzadeh
BACKGROUND: Nowadays use of specific antivenin for latrodectism is considered as the most effective treatment in the world. This study was undertaken to investigate the efficacy of specific antivenom against histopathological complications caused by Latrodectus dahli venom on liver, heart and kidneys tissues within 72h. METHODS: Two groups were selected, each one contained 6 male New Zealand rabbits weighing 2±0.5kg. The animals were anesthetized with 0.5ml ketamine and 0...
March 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/28970432/quality-of-life-and-medication-adherence-of-independently-living-older-adults-enrolled-in-a-pharmacist-based-medication-management-program
#10
Christopher Harlow, Catherine Hanna, Lynne Eckmann, Yevgeniya Gokun, Faika Zanjani, Karen Blumenschein, Holly Divine
This study sought to understand the medication adherence and quality of life (QOL) of recipients of a pharmacist-based medication management program among independently living older adults. Using a cross-sectional, quasi-experimental study design, we compared older adults enrolled in the program to older adults not enrolled in the program. Data were collected via face-to-face interviews in independent-living facilities and in participants' homes. Independently living older adults who were enrolled in the medication management program (n = 38) were compared to older adults not enrolled in the program (control group (n = 41))...
April 6, 2017: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/28843247/corrigendum-to-subarachnoid-space-transplantation-of-schwann-and-or-olfactory-ensheathing-cells-following-severe-spinal-cord-injury-fails-to-improve-locomotor-recovery-in-rats-acta-med-iran-2016-54-9-562-569
#11
Mohsen Nategh, Masoumeh Firouzi, Mehdi Naji-Tehrani, Leila Oryadi Zanjani, Zahra Hassannejad, Mohammad Hosein Nabian, Shayan Abdollah Zadegan, Mehrbod Karimi, Vafa Rahimi-Movaghar
No abstract text is available yet for this article.
June 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28811007/acceleration-of-skin-wound-healing-by-low-dose-indirect-ionizing-radiation-in-male-rats
#12
Nasrollah Jabbari, Gholam Hossein Farjah, Behnam Ghadimi, Hajar Zanjani, Behnam Heshmatian
A recent hypothesis has revealed that low-dose irradiation (LDI) with ionizing radiation might have a promoting effect on fracture healing. The aim of this study was to investigate the influence of direct (electron beam) and indirect (gamma-ray) low-dose ionizing irradiations on the wound healing process in male rats. In 72 male rats, a full-thickness wound was incised. The animals were randomly assigned to three groups, each with 24 rats. The first two groups were named IG-I and IG-II and respectively exposed to electron and gamma-radiations (75 cGy) immediately after the surgical procedure...
August 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28764535/note-a-portable-automatic-capillary-viscometer-for-transparent-and-opaque-liquids
#13
A Soltani Ghalehjooghi, S Minaei, N Gholipour Zanjani, B Beheshti
A portable automatic capillary viscometer, equipped with an AVR microcontroller, was designed and developed. The viscometer was calibrated with Certified Reference Material (CRM) s200 and utilized for measurement of kinematic viscosity. A quadratic equation was developed for calibration of the instrument at various temperatures. Also, a model was developed for viscosity determination in terms of the viscometer dimensions. Development of the portable viscometer provides for on-site monitoring of engine oil viscosity...
July 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28761210/bilateral-hyperplasia-of-bartholin-s-gland-a-case-report
#14
Ladan Haghighi, Mansooreh SHaabani Zanjani, Zahra Najmi, Neda Hashemi
A 37-year-old woman underwent surgery to remove bilateral vulvar masses. The masses were firm, non-tender, and immobile. Pathologic finding was a well-delineated creamy grayish mass with a homogenous grayish solid surface and mild edema, chronic inflammatory infiltration, and focal dilation of the ducts with squamous metaplasia. The diagnosis was hyperplastic and hypertrophied Bartholin's gland. Hyperplasia is a rare etiology for an enlarged Bartholin's gland. Clinical presentation of Bartholin's gland nodular hyperplasia is rather specific, although inflammatory lesion is the most common cause of swelling of the Bartholin's gland in all age groups...
July 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28697991/carbamazepine-effects-on-pain-management-and-serum-il-6-il-10-evaluation-in-addicted-patients-undergoing-surgery
#15
Alireza Salimi, Masoumeh Sabetkasaei, Hanna Raisi, Farzaneh Labibi, Haleh Ameli, Yalda Khazaei-Poul, Malek Zarei, Kamran Mottaghi, Farhad Safari, Ali Nazem-Bokaei, Seyed-Amir Mohajerani, Taraneh Moini-Zanjani
Postoperative pain control remains an important issue in the field of surgery. Assessing and managing patients with acute pain who are addicted to opioids are often challenging. It has been shown that, addicted patients are less tolerant to pain. There is limited evidence to guide the management of acute pain in these patients. Here we studied the effect of preemptive use of carbamazepine on pain behavior and serum IL-6, IL-10 levels in the addicted patients. 90 male patients (25-45 years, BMI 20-27), were divided into 3 group of 30 patients: 1- control, 2- addicted, 3- addicted patients receiving carbamazepine 400mg before surgery...
July 8, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28540553/multivariate-analysis-and-geochemical-approach-for-assessment-of-metal-pollution-state-in-sediment-cores
#16
Ahmad Jamshidi-Zanjani, Mohsen Saeedi
Vertical distribution of metals (Cu, Zn, Cr, Fe, Mn, Pb, Ni, Cd, and Li) in four sediment core samples (C1, C2, C3, and C4) from Anzali international wetland located southwest of the Caspian Sea was examined. Background concentration of each metal was calculated according to different statistical approaches. The results of multivariate statistical analysis showed that Fe and Mn might have significant role in the fate of Ni and Zn in sediment core samples. Different sediment quality indexes were utilized to assess metal pollution in sediment cores...
July 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28507468/paradoxical-effect-of-minocycline-on-established-neuropathic-pain-in-rat
#17
Malek Zarei, Masoumeh Sabetkasaei, Taraneh Moini-Zanjani
Neuropathic pain occurs after peripheral nerve damage, inflammation or infection. In this situation, microglial cells become activated and play a key role in producing pain. Minocycline (microglia inhibitor), was reported to reduce pain when used preventively. However, it seems that, when used after nerve injury, results in its pain reducing effects are different. In this regard, to assess the pain reducing differences of minocycline, neuropathic pain was induced by the ligation of the sciatic nerve in the rat which is recognized as chronic constriction injury (CCI) and minocycline was administered before and after sciatic nerve injury...
2017: EXCLI Journal
https://www.readbyqxmd.com/read/28496467/interference-free-determination-of-carbamazepine-in-human-serum-using-high-performance-liquid-chromatography-a-comprehensive-research-with-three-way-calibration-methods
#18
Shiva Ghafghazi, Taraneh Moini Zanjani, Maryam Vosough, Masoumeh Sabetkasaei
In the present study, a comprehensive and systematic strategy was described to evaluate the performance of several three-way calibration methods on a bio-analytical problem. Parallel factor analysis (PARAFAC), alternating trilinear decomposition (ATLD), self-weighted alternating trilinear decomposition (SWATLD), alternating penalty trilinear decomposition (APTLD), and unfolded partial least squares combined with the residual bilinearization procedure (U-PLS/RBL) were applied on high performance liquid chromatography with photodiode-array detection (HPLC-DAD) data to quantify carbamazepine (CBZ) in different serum samples...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28483181/decreased-levels-of-spleen-tissue-cd4-cd25-foxp3-regulatory-t-lymphocytes-in-mice-exposed-to-berberine
#19
Gholamreza Karimi, Mahmoud Mahmoudi, Mahdi Balali-Mood, Maryam Rahnama, Shahrzad Zamani Taghizadeh Rabe, Nafiseh Tabasi, Bamdad Riahi-Zanjani
The effects of isoquinoline alkaloid berberine (BER) on spleen tissue CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells were evaluated in BALB/c mice. Here, BER was administered daily by intraperitoneal injection at doses of 5 mg/kg and 10 mg/kg for 14 days. Following the exposure, mice spleen cellularities, IL-10 production by splenocytes, and spleen Treg/CD4(+) cell profiles were studied in all the test groups of animals. The results showed that a high dose of BER (10 mg/kg) could decrease both the absolute and relative percentages of spleen Treg cells as well as decrease the production of IL-10 by splenocytes in the treated mice (p<0...
April 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/28464782/from-ocean-to-bedside-the-therapeutic-potential-of-molluscan-hemocyanins
#20
Negar Talaei Zanjani, Monica Miranda Saksena, Fariba Dehghani, Anthony L Cunningham
Hemocyanins are large and versatile glycoproteins performing various immunological and biological functions in many marine invertebrates including arthropods and molluscs. This review discusses the various pharmacological applications of mollusc hemocyanin such as antiviral activity, immunostimulatory and anticancer properties that have been reported in the literature between the years 2000 and 2016. Emphasis is placed on a better mechanistic understanding of hemocyanin as a therapeutic agent. Elucidation of the mechanism of action is essential to improve the clinical efficacy and for a better understanding of some endogenous immunological functions of this complex glycoprotein...
May 2, 2017: Current Medicinal Chemistry
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