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Franziska C Sandmeier, Chava L Weitzman, K Nichole Maloney, C Richard Tracy, Nathan Nieto, Mike B Teglas, Kenneth W Hunter, Sally DuPré, C M Gienger, Michael W Tuma
Pathogens that cause subclinical diseases or exhibit low infection intensities are difficult to quantify in wild populations. Mojave desert tortoises ( Gopherus agassizii ) have been the focus of much research aimed at measuring the presence of upper respiratory disease (URTD) and URTD-associated pathogens, and techniques used to quantify disease in Gopherus species have also been used for disease surveillance in other species of turtles and tortoises of conservation concern. Published surveys of G. agassizii populations have found a relatively low prevalence of URTD, with most URTD-positive animals exhibiting moderate, intermittent signs of morbidity...
October 27, 2016: Journal of Wildlife Diseases
Ernő Téglás, Luca L Bonatti
Infants look at physically impossible events longer than at physically possible events, and at improbable events longer than at probable events. Such behaviors are generally interpreted as showing that infants have expectations about future events and are surprised to see them violated. It is unknown, however, whether and under what conditions infants form proactive expectations about the future, as opposed to realizing post hoc that outcomes do not comply with their previous knowledge or experience. Here we investigate the relation between expectation and surprise at probabilistic or deterministic events in preverbal infants...
September 22, 2016: Cognition
G Saliou, I Vraka, J Teglas, M Senat, P Durand, C Colmant, A Ozanne, J Martinovic, P Tissieres, C Adamsbaum
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
Nilesh Jeevandas Washnik, Susan L Phillips, Sandra Teglas
Previous studies have shown that collegiate level music students are exposed to potentially hazardous sound levels. Compared to professional musicians, collegiate level music students typically do not perform as frequently, but they are exposed to intense sounds during practice and rehearsal sessions. The purpose of the study was to determine the full-day exposure dose including individual practice and ensemble rehearsals for collegiate student musicians. Sixty-seven college students of classical music were recruited representing 17 primary instruments...
March 2016: Noise & Health
Thierry Prazuck, Stephen Karon, Camelia Gubavu, Jerome Andre, Jean Marie Legall, Elisabeth Bouvet, Georges Kreplak, Jean Paul Teglas, Gilles Pialoux
BACKGROUND: In 2013, the French Health Authority approved the use of HIV self-tests in pharmacies for the general public. This screening tool will allow an increase in the number of screenings and a reduction in the delay between infection and diagnosis, thus reducing the risk of further infections. We previously compared 5 HIV-self test candidates (4 oral fluid and one whole blood) and demonstrated that the whole blood HIV test exhibited the optimal level of performance (sensitivity/specificity)...
2016: PloS One
B Morel, G Antoni, J P Teglas, I Bloch, C Adamsbaum
No abstract text is available yet for this article.
February 2016: Neuroradiology
B Morel, G Antoni, J P Teglas, I Bloch, C Adamsbaum
INTRODUCTION: White matter (WM) analysis in neonatal brain magnetic resonance imaging (MRI) is challenging, as demonstrated by the issue of diffuse excessive high signal intensity (DEHSI). We evaluated the reliability of the radiologist's eye in this context. METHODS: Three experienced observers graded the WM signal intensity on axial T2-weighted 1.5T images from 60 different premature newborns on 2 occasions 4 weeks apart with a semi-quantitative classification under identical viewing conditions...
February 2016: Neuroradiology
Adam M Kruszewski, Gautam Rao, Alexandru Tatomir, Daniel Hewes, Cosmin A Tegla, Cornelia D Cudrici, Vingh Nguyen, Walter Royal, Christopher T Bever, Violeta Rus, Horea Rus
Currently there is critical need for the identification of reliable biomarkers to help guide clinical management of multiple sclerosis (MS) patients. We investigated the combined roles of Response Gene to Complement 32 (RGC-32), FasL, CDC2, AKT, and IL-21 as possible biomarkers of relapse and response to glatiramer acetate (GA) treatment in relapsing-remitting MS (RRMS) patients. Over the course of 2 years, a cohort of 15 GA-treated RRMS patients was clinically monitored and peripheral blood mononuclear cells (PBMCs) were collected at 0, 3, 6, and 12 months...
December 2015: Experimental and Molecular Pathology
Jonathan Phillips, Desmond C Ong, Andrew D R Surtees, Yijing Xin, Samantha Williams, Rebecca Saxe, Michael C Frank
In recent work, Kovács, Téglás, and Endress (2010) argued that human adults automatically represented other agents' beliefs even when those beliefs were completely irrelevant to the task being performed. In a series of 13 experiments, we replicated these previous findings but demonstrated that the effects found arose from artifacts in the experimental paradigm. In particular, the critical findings demonstrating automatic belief computation were driven by inconsistencies in the timing of an attention check, and thus do not provide evidence for automatic theory of mind in adults...
September 2015: Psychological Science
Susan L Phillips, Scott J Richter, Sandra L Teglas, Ishan S Bhatt, Robin C Morehouse, Elizabeth R Hauser, Vincent C Henrich
OBJECTIVE: Noise-induced hearing loss (NIHL) is a worldwide health problem and a growing concern among young people. Although some people appear to be more susceptible to NIHL, genetic association studies lack a specific phenotype. We tested the feasibility of a bilateral 4000-6000 Hz audiometric notch as a phenotype for identifying genetic contributions to hearing loss in young adults. DESIGN: A case-control-control study was conducted to examine selected SNPs in 52 genes previously associated with hearing loss and/or expressed in the cochlea...
2015: International Journal of Audiology
Cosmin A Tegla, Cornelia D Cudrici, Vinh Nguyen, Jacob Danoff, Adam M Kruszewski, Dallas Boodhoo, Armugam P Mekala, Sonia I Vlaicu, Ching Chen, Violeta Rus, Tudor C Badea, Horea Rus
We have previously shown that RGC-32 is involved in cell cycle regulation in vitro. To define the in vivo role of RGC-32, we generated RGC-32 knockout mice. These mice developed normally and did not spontaneously develop overt tumors. To assess the effect of RGC-32 deficiency on cell cycle activation in T cells, we determined the proliferative rates of CD4(+) and CD8(+) T cells from the spleens of RGC-32(-/-) mice, as compared to wild-type (WT, RGC-32(+/+)) control mice. After stimulation with anti-CD3/anti-CD28, CD4(+) T cells from RGC-32(-/-) mice displayed a significant increase in [(3)H]-thymidine incorporation when compared to WT mice...
June 2015: Experimental and Molecular Pathology
Molly J Bechtel, Michael B Teglas, Peter J Murphy, Marjorie D Matocq
Patterns of host-parasite association may vary across the landscape in part because of host and parasite diversity, divergence, local ecology, or interactions among these factors. In central coastal California, we quantified parasite prevalence, infection intensity, and diversity in two sister species of woodrats (Neotoma fuscipes and Neotoma macrotis) where the species co-occur (sympatry) and where each species exists alone (allopatry). In feces from 50 adults we identified seven taxa: the protozoans Eimeria, Giardia, and Cryptosporidium, the nematodes Trichuris, Aspicularis, and Eucoleus, and a cestode in the family Anoplocephalidae...
April 2015: Journal of Wildlife Diseases
Alvaro Martin, Cosmin A Tegla, Cornelia D Cudrici, Adam M Kruszewski, Philippe Azimzadeh, Dallas Boodhoo, Armugam P Mekala, Violeta Rus, Horea Rus
Multiple sclerosis (MS) is a demyelinating disease characterized by chronic inflammation of the central nervous system, in which many factors can act together to influence disease susceptibility and progression. SIRT1 is a member of the histone deacetylase class III family of proteins and is an NAD(+)-dependent histone and protein deacetylase. SIRT1 can induce chromatin silencing through the deacetylation of histones and plays an important role as a key regulator of a wide variety of cellular and physiological processes including DNA damage, cell survival, metabolism, aging, and neurodegeneration...
March 2015: Immunologic Research
Nathan C Nieto, Mike B Teglas
Wild rodent reservoir host species were surveyed prospectively for infection with Borrelia hermsii, the causative agent of tick-borne relapsing fever in the western United States. Trapping occurred during the summer of 2009-2012 at field sites surrounding Big Bear Lake, CA, a region where human infection has been reported for many years. Using quantitative polymerase chain reaction (qPCR), we tested 207 rodents from 11 species and found chipmunks (Tamias spp.) and a woodrat (Neotoma macrotis) infected. Chipmunks represented the majority of captures at these sites...
September 2014: Journal of Medical Entomology
Myra T Blanchard, Mark L Anderson, Bruce R Hoar, Alda F A Pires, Patricia C Blanchard, Bret V Yeargan, Mike B Teglas, Margaret Belshaw, Jeffery L Stott
The current study was directed at developing and validating an indirect fluorescent antibody test (IFAT) capable of detecting antibodies specific for the agent of epizootic bovine abortion (aoEBA). Sensitivity and specificity was determined by comparing antibody titers from 114 fetuses infected with aoEBA with 68 fetuses diagnosed with alternate infectious etiologies. Data established specificity at 100% and sensitivity at 94.7% when cutoff criteria for a positive test were assigned at a titer of ≥1,000. Potential cross-reactivity was noted in samples from 3 fetuses with antibody titers of 10 or100; all were infected with Gram-positive organisms...
September 2014: Journal of Veterinary Diagnostic Investigation
Ernő Téglás, Alexandra Ibanez-Lillo, Albert Costa, Luca L Bonatti
Recent research shows that preverbal infants can reason about single-case probabilities without relying on observed frequencies, adapting their predictions to relevant dynamic parameters of the situation (Téglás, Vul, Girotto, Gonzalez, Tenenbaum & Bonatti, ; Téglás, Girotto, Gonzalez & Bonatti, ). Here we show that intuitions of probabilities may derive from the ability to represent a limited number of possibilities. After watching a scene containing moving objects of two ensembles, 12-month-olds looked longer at an unlikely than at a likely single-case outcome when the objects were within the parallel individuation range...
March 2015: Developmental Science
Damien C Weber, Veronique Vallet, Andrea Molineu, Christos Melidis, Vanda Teglas, Suzanne Naudy, Raphael Moeckli, David S Followill, Coen W Hurkmans
BACKGROUND AND PURPOSE: Intensity-modulated radiotherapy (IMRT) credentialing for a EORTC study was performed using an anthropomorphic head phantom from the Radiological Physics Center (RPC; RPC(PH)). Institutions were retrospectively requested to irradiate their institutional phantom (INST(PH)) using the same treatment plan in the framework of a Virtual Phantom Project (VPP) for IMRT credentialing. MATERIALS AND METHODS: CT data set of the institutional phantom and measured 2D dose matrices were requested from centers and sent to a dedicated secure EORTC uploader...
2014: Radiation Oncology
Cosmin A Tegla, Philippe Azimzadeh, Maria Andrian-Albescu, Alvaro Martin, Cornelia D Cudrici, Richard Trippe, Adam Sugarman, Hegang Chen, Dallas Boodhoo, Sonia I Vlaicu, Walter Royal, Christopher Bever, Violeta Rus, Horea Rus
SIRT1 is a member of the histone deacetylase (HDAC) class III family of proteins and is an NAD-dependent histone and protein deacetylase. SIRT1 can induce chromatin silencing through the deacetylation of histones and can modulate cell survival by regulating the transcriptional activities. We investigated the expression of SIRT1 in multiple sclerosis (MS) brains and in peripheral blood mononuclear cells (PBMCs) obtained from patients with relapsing-remitting multiple sclerosis. We found that SIRT1 was expressed by a significant number of cells in both acute and chronic active lesions...
April 2014: Experimental and Molecular Pathology
Zoltán Mátrai, Ferenc Bánhidy, Melinda Téglás, Eszter Kovács, Akos Sávolt, Nóra Udvarhelyi, Alexandra Bartal, Miklós Kásler
The incidence of pregnancy-associated breast cancer is rising. Sentinel lymph node biopsy is the method of choice in clinically node negative cases as the indicated minimally invasive regional staging procedure. Some reports have linked radioisotope and blue dye required for lymphatic mapping to teratogenic effects, the idea of which has become a generalized statement and, until recently, contraindication for these agents was considered during pregnancy. Today, there are many published reports of successful interventions with low-dose 99mTc-labeled human albumin nanocolloid, based on dosimetric modeling demonstrating a negligible radiation exposure of the fetus...
December 1, 2013: Orvosi Hetilap
Sonia I Vlaicu, Cosmin A Tegla, Cornelia D Cudrici, Jacob Danoff, Hassan Madani, Adam Sugarman, Florin Niculescu, Petru A Mircea, Violeta Rus, Horea Rus
Complement system activation plays an important role in both innate and acquired immunity, with the activation of complement and the subsequent formation of C5b-9 terminal complement complex on cell membranes inducing target cell death. Recognition of this role for C5b-9 leads to the assumption that C5b-9 might play an antitumor role. However, sublytic C5b-9 induces cell cycle progression by activating signal transduction pathways and transcription factors in cancer cells, indicating a role in tumor promotion for this complement complex...
May 2013: Immunologic Research
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