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https://www.readbyqxmd.com/read/29702177/whole-body-pulsed-emf-stimulation-improves-cognitive-and-psychomotor-activity-in-senescent-rats
#1
Tímea Téglás, Gabriella Dörnyei, Károly Bretz, Csaba Nyakas
During advanced aging passive exercise (PE) is becoming a valuable therapeutic intervention to improve physical and mental performances. In the present study chronic low frequency pulsed electromagnetic field (EMF) exposure was presented to senescent rats in order to clarify the behavioural effects related to cognitive and motility functions. Male Wistar rats of 30-32 months old were treated with EMF for six weeks, 3 times per week, 24 min per sessions prior to the age of 32 months. Stimulation intensities varied from 45 to 1250 µT...
April 24, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29590076/precursors-of-logical-reasoning-in-preverbal-human-infants
#2
Nicoló Cesana-Arlotti, Ana Martín, Ernő Téglás, Liza Vorobyova, Ryszard Cetnarski, Luca L Bonatti
Infants are able to entertain hypotheses about complex events and to modify them rationally when faced with inconsistent evidence. These capacities suggest that infants can use elementary logical representations to frame and prune hypotheses. By presenting scenes containing ambiguities about the identity of an object, here we show that 12- and 19-month-old infants look longer at outcomes that are inconsistent with a logical inference necessary to resolve such ambiguities. At the moment of a potential deduction, infants' pupils dilated, and their eyes moved toward the ambiguous object when inferences could be computed, in contrast to transparent scenes not requiring inferences to identify the object...
March 16, 2018: Science
https://www.readbyqxmd.com/read/29474559/genomic-alterations-and-complex-subclonal-architecture-in-sporadic-gh-secreting-pituitary-adenomas
#3
Mirella Hage, Say Viengchareun, Erika Brunet, Chiara Villa, Dominique Pineau, Jérôme Bouligand, Jean-Paul Teglas, Clovis Adam, Fabrice Parker, Marc Lombès, Gérard Tachdjian, Stéphane Gaillard, Philippe Chanson, Lucie Tosca, Peter Kamenický
Purpose: The molecular pathogenesis of growth hormone-secreting pituitary adenomas is not fully understood. Cytogenetic alterations might serve as alternative driver events in GNAS mutation-negative somatotroph tumors. Experimental Design: We performed cytogenetic profiling of pituitary adenomas obtained from 39 patients with acromegaly and four patients with sporadic gigantism by using array comparative genomic hybridization analysis. We explored intratumor DNA copy-number heterogeneity in two tumor samples by using DNA fluorescence in situ hybridization (FISH)...
May 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29126966/host-plant-associated-enhancement-of-immunity-and-survival-in-virus-infected-caterpillars
#4
Angela M Smilanich, Tara C Langus, Lydia Doan, Lee A Dyer, Joshua G Harrison, Jennifer Hsueh, Mike B Teglas
Understanding the interaction between host plant chemistry, the immune response, and insect pathogens can shed light on host plant use by insect herbivores. In this study, we focused on how interactions between the insect immune response and plant secondary metabolites affect the response to a viral pathogen. Based upon prior research, we asked whether the buckeye caterpillar, Junonia coenia (Nymphalidae), which specializes on plants containing iridoid glycosides (IGs), is less able to resist the pathogenic effects of a densovirus infection when feeding on plants with high concentrations of IGs...
January 2018: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29122221/qualitative-and-quantitative-contrast-enhanced-ultrasonography-for-the-characterisation-of-non-palpable-testicular-tumours
#5
A Luzurier, F Maxwell, J M Correas, G Benoit, V Izard, S Ferlicot, J P Teglas, M F Bellin, L Rocher
AIM: To assess the diagnostic performance of conventional ultrasound (US) and contrast-enhanced ultrasonography (CEUS) in the differential diagnosis of non-palpable intratesticular tumours. MATERIALS AND METHODS: The local ethics review board approved the protocol, and all of the patients provided written informed consent. Between December 2011 and February 2014, men with non-palpable testicular tumours and normal tumour markers who were referred for surgery were included...
March 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29103986/cold-inducible-promoter-driven-cre-lox-system-proved-to-be-highly-efficient-for-marker-gene-excision-in-transgenic-barley
#6
Csaba Éva, Flóra Téglás, Helga Zelenyánszki, Cecília Tamás, Angéla Juhász, Klára Mészáros, László Tamás
A Cre-lox based auto-excision strategy has been adapted for barley, capable of cre and selectable marker gene (SMG) removal. The cold inducible wheat promoter called wcs120 was utilised for driving Cre expression. The binary vector was carrying the transgene (uidA) and a so called 'recombination cassette' flanked by the lox sequences. This part included both the recombinase gene and the SMG (bar) under the control of a constitutive promoter. T0 , T1 and T2 transgenic plants were subjected to low temperature (at 4°C, 10°C and 12°C) at different developmental stages to induce recombination...
January 10, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29084219/ecological-niche-modeling-and-distribution-of-ornithodoros-hermsi-associated-with-tick-borne-relapsing-fever-in-western-north-america
#7
Kylie M Sage, Tammi L Johnson, Michael B Teglas, Nathan C Nieto, Tom G Schwan
Tick-borne relapsing fever in western North America is a zoonosis caused by the spirochete bacterium, Borrelia hermsii, which is transmitted by the bite of infected Ornithodoros hermsi ticks. The pathogen is maintained in natural cycles involving small rodent hosts such as chipmunks and tree squirrels, as well as the tick vector. In order for these ticks to establish sustained and viable populations, a narrow set of environmental parameters must exist, primarily moderate temperatures and moderate to high amounts of precipitation...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29076269/seeing-behind-the-surface-communicative-demonstration-boosts-category-disambiguation-in-12-month-olds
#8
Ágnes M Kovács, Ernő Téglás, György Gergely, Gergely Csibra
In their first years, infants acquire an incredible amount of information regarding the objects present in their environment. While often it is not clear what specific information should be prioritized in encoding from the many characteristics of an object, different types of object representations facilitate different types of generalizations. We tested the hypotheses that 1-year-old infants distinctively represent familiar objects as exemplars of their kind, and that ostensive communication plays a role in determining kind membership for ambiguous objects...
November 2017: Developmental Science
https://www.readbyqxmd.com/read/28742467/polycystic-ovary-syndrome-in-adolescents-which-mr-imaging-based-diagnostic-criteria
#9
COMPARATIVE STUDY
Maxime Fondin, Antoine Rachas, Van Huynh, Stéphanie Franchi-Abella, Jean-Paul Teglas, Lise Duranteau, Catherine Adamsbaum
Purpose To evaluate the validity and reproducibility of magnetic resonance (MR) imaging-based ovarian morphologic measurements for diagnosis of polycystic ovary syndrome (PCOS) in adolescents. Materials and Methods This case-control study included 110 adolescent girls (age range, 13-17 years) who underwent pelvic MR imaging in 2006-2015. The case group included girls with high (n = 40, hyperandrogenism and oligomenorrhea or amenorrhea), intermediate (n = 8, hyperandrogenism), or low (n = 7, oligomenorrhea or amenorrhea) suspicion of PCOS...
December 2017: Radiology
https://www.readbyqxmd.com/read/28586918/effect-of-nebulized-hypertonic-saline-treatment-in-emergency-departments-on-the-hospitalization-rate-for-acute-bronchiolitis-a-randomized-clinical-trial
#10
RANDOMIZED CONTROLLED TRIAL
François Angoulvant, Xavier Bellêttre, Karen Milcent, Jean-Paul Teglas, Isabelle Claudet, Christèle Gras Le Guen, Loïc de Pontual, Philippe Minodier, François Dubos, Jacques Brouard, Valérie Soussan-Banini, Vanessa Degas-Bussiere, Amélie Gatin, Cyril Schweitzer, Ralph Epaud, Amélie Ryckewaert, Pierrick Cros, Yves Marot, Philippe Flahaut, Pascal Saunier, Philippe Babe, Géraldine Patteau, Mathilde Delebarre, Luigi Titomanlio, Bénédicte Vrignaud, Thanh-Van Trieu, Abdelilah Tahir, Delphine Regnard, Pascale Micheau, Oussama Charara, Simon Henry, Dominique Ploin, Henri Panjo, Astrid Vabret, Jean Bouyer, Vincent Gajdos
Importance: Acute bronchiolitis is the leading cause of hospitalization among infants. Previous studies, underpowered to examine hospital admission, have found a limited benefit of nebulized hypertonic saline (HS) treatment in the pediatric emergency department (ED). Objective: To examine whether HS nebulization treatment would decrease the hospital admission rate among infants with a first episode of acute bronchiolitis. Design, Setting, and Participants: The Efficacy of 3% Hypertonic Saline in Acute Viral Bronchiolitis (GUERANDE) study was a multicenter, double-blind randomized clinical trial on 2 parallel groups conducted during 2 bronchiolitis seasons (October through March) from October 15, 2012, through April 15, 2014, at 24 French pediatric EDs...
August 7, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28356385/rgc-32-promotes-th17-cell-differentiation-and-enhances-experimental-autoimmune-encephalomyelitis
#11
Violeta Rus, Vinh Nguyen, Alexandru Tatomir, Jason R Lees, Armugam P Mekala, Dallas Boodhoo, Cosmin A Tegla, Irina G Luzina, Paul A Antony, Cornelia D Cudrici, Tudor C Badea, Horea G Rus
Th17 cells play a critical role in autoimmune diseases, including multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis. Response gene to complement (RGC)-32 is a cell cycle regulator and a downstream target of TGF-β that mediates its profibrotic activity. In this study, we report that RGC-32 is preferentially upregulated during Th17 cell differentiation. RGC-32-/- mice have normal Th1, Th2, and regulatory T cell differentiation but show defective Th17 differentiation in vitro...
May 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28189035/current-evidence-for-automatic-theory-of-mind-processing-in-adults
#12
Dana Schneider, Virginia P Slaughter, Paul E Dux
Theory of Mind (ToM) is thought to play a key role in social information processing as it refers to the ability of individuals to represent the mental states of others (e.g., intentions, desires, beliefs). A provocative hypothesis has been put forward which espouses the existence of two ToM systems: one that is implicit and involves the automatic analysis of the belief states of others and another that is not automatic and is involved in explicitly reasoning about others' mental states. Recently, Phillips et al...
May 2017: Cognition
https://www.readbyqxmd.com/read/28109694/sirt1-as-a-potential-biomarker-of-response-to-treatment-with-glatiramer-acetate-in-multiple-sclerosis
#13
Daniel Hewes, Alexandru Tatomir, Adam M Kruszewski, Gautam Rao, Cosmin A Tegla, Jonathan Ciriello, Vingh Nguyen, Walter Royal, Christopher Bever, Violeta Rus, Horea Rus
SIRT1, a NAD dependent histone and protein deacetylase, is a member of the histone deacetylase class III family. We previously showed that SIRT1 mRNA expression is significantly lower in peripheral blood mononuclear cells (PBMCs) of multiple sclerosis (MS) patients during relapses than in stable patients. We have now investigated SIRT1 as a possible biomarker to predict relapse as well as responsiveness to glatiramer acetate (GA) treatment in relapsing-remitting MS (RRMS) patients. Over the course of 2years, a cohort of 15 GA-treated RRMS patients were clinically monitored using the Expanded Disability Status Scale and assessed for MS relapses...
April 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28076893/pseudofeeders-on-fetal-magnetic-resonance-imaging-predict-outcome-in-vein-of-galen-malformations
#14
Guillaume Saliou, Irène Vraka, Jean-Paul Teglas, Marie-Victoire Senat, Philippe Durand, Claire Colmant, Augustin Ozanne, Jelena Martinovic, Pierre Tissiere, Catherine Adamsbaum
OBJECTIVE: Although vein of Galen aneurysmal malformations (VGAM) can be diagnosed in the fetus, the challenge is predicting the occurrence of its 2 major complications: cardiopulmonary failure and encephalomalacia. This study attempts to determine which fetal brain magnetic resonance imaging (MRI) features might be used to predict the development of these complications at birth. METHODS: The cohort was extracted from a prospectively assembled database of VGAM cases managed at a single referral center from 2000 to 2014...
February 2017: Annals of Neurology
https://www.readbyqxmd.com/read/27989225/-unaffected-child-born-following-preimplantation-genetic-diagnosis-with-karyomapping
#15
László Nánássy, Gyöngyvér Téglás, Marianna Csenki, Attila Vereczkey
Preimplantation genetic diagnosis for single gene defects is a well established method in assisted reproductive technologies. Karyomapping is a genome wide parental haplotyping using a high density single nucleotide polymorphism array that allows the diagnosis of any single gene defects. A couple with an affected child with primary congenital glaucoma attended at our clinic. Six oocyte-cumulus-complex was retrieved and all three mature oocytes were inseminated. One zygote showed the signs of normal fertilization and was cultured for five days...
December 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27788056/comparison-of-current-methods-for-the-detection-of-chronic-mycoplasmal-urtd-in-wild-populations-of-the-mojave-desert-tortoise-gopherus-agassizii
#16
Franziska C Sandmeier, Chava L Weitzman, K Nichole Maloney, C Richard Tracy, Nathan Nieto, Mike B Teglas, Kenneth W Hunter, Sally DuPré, C M Gienger, Michael W Tuma
Pathogens that cause subclinical diseases or exhibit low infection intensities are difficult to quantify in wild populations. Mojave desert tortoises ( Gopherus agassizii ) have been the focus of much research aimed at measuring the presence of upper respiratory disease (URTD) and URTD-associated pathogens, and techniques used to quantify disease in Gopherus species have also been used for disease surveillance in other species of turtles and tortoises of conservation concern. Published surveys of G. agassizii populations have found a relatively low prevalence of URTD, with most URTD-positive animals exhibiting moderate, intermittent signs of morbidity...
January 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/27665395/infants-anticipate-probabilistic-but-not-deterministic-outcomes
#17
Ernő Téglás, Luca L Bonatti
Infants look at physically impossible events longer than at physically possible events, and at improbable events longer than at probable events. Such behaviors are generally interpreted as showing that infants have expectations about future events and are surprised to see them violated. It is unknown, however, whether and under what conditions infants form proactive expectations about the future, as opposed to realizing post hoc that outcomes do not comply with their previous knowledge or experience. Here we investigate the relation between expectation and surprise at probabilistic or deterministic events in preverbal infants...
December 2016: Cognition
https://www.readbyqxmd.com/read/27645919/abstracts-of-the-26th-world-congress-on-ultrasound-in-obstetrics-and-gynecology-rome-italy-24-28-september-2016
#18
G Saliou, I Vraka, J Teglas, M Senat, P Durand, C Colmant, A Ozanne, J Martinovic, P Tissieres, C Adamsbaum
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/26960787/student-s-music-exposure-full-day-personal-dose-measurements
#19
Nilesh Jeevandas Washnik, Susan L Phillips, Sandra Teglas
Previous studies have shown that collegiate level music students are exposed to potentially hazardous sound levels. Compared to professional musicians, collegiate level music students typically do not perform as frequently, but they are exposed to intense sounds during practice and rehearsal sessions. The purpose of the study was to determine the full-day exposure dose including individual practice and ensemble rehearsals for collegiate student musicians. Sixty-seven college students of classical music were recruited representing 17 primary instruments...
March 2016: Noise & Health
https://www.readbyqxmd.com/read/26882229/a-finger-stick-whole-blood-hiv-self-test-as-an-hiv-screening-tool-adapted-to-the-general-public
#20
Thierry Prazuck, Stephen Karon, Camelia Gubavu, Jerome Andre, Jean Marie Legall, Elisabeth Bouvet, Georges Kreplak, Jean Paul Teglas, Gilles Pialoux
BACKGROUND: In 2013, the French Health Authority approved the use of HIV self-tests in pharmacies for the general public. This screening tool will allow an increase in the number of screenings and a reduction in the delay between infection and diagnosis, thus reducing the risk of further infections. We previously compared 5 HIV-self test candidates (4 oral fluid and one whole blood) and demonstrated that the whole blood HIV test exhibited the optimal level of performance (sensitivity/specificity)...
2016: PloS One
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