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Hyaluronan

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https://www.readbyqxmd.com/read/29673760/tumor-suppressive-functions-of-4-mu-on-breast-cancer-cells-of-different-er-status-regulation-of-hyaluronan-has2-cd44-and-specific-matrix-effectors
#1
Theodoros T Karalis, Paraskevi Heldin, Demitrios H Vynios, Thomas Neill, Simone Buraschi, Renato V Iozzo, Nikos K Karamanos, Spyros S Skandalis
The malignant phenotype of various cancers is linked to enhanced expression of hyaluronan, a pro-angiogenic glycosaminoglycan whose expression is suppressed by 4-methylumbelliferone (4-MU), a non-toxic oral agent used as a dietary supplement to improve health and combat prostate cancer. However, little is known about the effects of hyaluronan inhibition by 4-MU on breast cancer cells. In this study, we investigated the role of 4-MU in mammary carcinoma cells with distinct malignant phenotypes and estrogen receptor (ER) status, a major prognostic factor in the clinical management of breast cancers...
April 16, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29672913/knockout-of-hyaluronan-synthase-1-but-not-3-impairs-formation-of-the-retrocalcaneal-bursa
#2
Katie J Sikes, Kristen Renner, Jun Li, K Jane Grande-Allen, Jennifer P Connell, Valbona Cali, Ronald J Midura, John D Sandy, Anna Plaas, Vincent M Wang
Hyaluronan (HA), a high molecular weight non-sulfated glycosaminoglycan, is an integral component of the extracellular matrix of developing and mature connective tissues including tendon. There are few published reports quantifying HA content during tendon growth and maturation, or detailing its effects on the mechanical properties of the tendon extracellular matrix. Therefore, the goal of the current study was to examine the role of HA synthesis during post-natal skeletal growth and maturation, and its influence on tendon structure and biomechanical function...
April 19, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29670170/y-box-protein-associated-acidic-protein-ybap1-c1qbp-affects-the-localization-and-cytoplasmic-functions-of-yb-1
#3
Ken Matsumoto, Shingo Kose, Iku Kuwahara, Mami Yoshimura, Naoko Imamoto, Minoru Yoshida
The Y-box proteins are multifunctional nucleic acid-binding proteins involved in various aspects of gene regulation. The founding member of the Y-box protein family, YB-1, functions as a transcription factor as well as a principal component of messenger ribonucleoprotein particles (mRNPs) in somatic cells. The nuclear level of YB-1 is well correlated with poor prognosis in many human cancers. Previously, we showed that a Y-box protein-associated acidic protein, YBAP1, which is identical to complement component 1, q subcomponent-binding protein (C1QBP, also called gC1qR, hyaluronan-binding protein 1 [HABP1] or ASF/SF2-associated protein p32), relieves translational repression by YB-1...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29670009/pursuing-intracellular-pathogens-with-hyaluronan-from-a-pro-infection-polymer-to-a-biomaterial-for-trojan-horse-systems
#4
REVIEW
Elita Montanari, Chiara Di Meo, Angela Oates, Tommasina Coviello, Pietro Matricardi
Hyaluronan (HA) is among the most important bioactive polymers in mammals, playing a key role in a number of biological functions. In the last decades, it has been increasingly studied as a biomaterial for drug delivery systems, thanks to its physico-chemical features and ability to target and enter certain cells. The most important receptor of HA is ‘Cluster of Differentiation 44’ (CD44), a cell surface glycoprotein over-expressed by a number of cancers and heavily involved in HA endocytosis...
April 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29666119/depot-specific-characteristics-of-adipose-tissue-derived-stromal-cells-in-thyroid-associated-orbitopathy
#5
Janice Siu Chong Wong, Wai Kit Chu, Benjamin Fuk-Loi Li, Chi-Pui Pang, Kelvin Kam-Lung Chong
BACKGROUND: Thyroid-associated orbitopathy (TAO) causes inflammatory fibroproliferation of periocular connective tissues. We compared adipose tissue-derived stem/stromal cells (ADSCs) from three adipose depots of each patient with TAO on mesenchymal, myofibrogenic, adipogenic properties and associated hyaluronan (HA) synthesis. METHODS: ADSCs were generated from periocular (eyelid, orbital) and subcutaneous (abdominal) adipose tissues of three patients with TAO...
April 17, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29664021/a-tlr-akt-foxo3-immune-tolerance-like-pathway-disrupts-the-repair-capacity-of-oligodendrocyte-progenitors
#6
Taasin Srivastava, Parham Diba, Justin M Dean, Fatima Banine, Daniel Shaver, Matthew Hagen, Xi Gong, Weiping Su, Ben Emery, Daniel L Marks, Edward N Harris, Bruce Baggenstoss, Paul H Weigel, Larry S Sherman, Stephen A Back
Cerebral white matter injury (WMI) persistently disrupts myelin regeneration by oligodendrocyte progenitor cells (OPCs). We identified a specific bioactive hyaluronan fragment (bHAf) that downregulates myelin gene expression and chronically blocks OPC maturation and myelination via a tolerance-like mechanism that dysregulates pro-myelination signaling via AKT. Desensitization of AKT occurs via TLR4 but not TLR2 or CD44. OPC differentiation was selectively blocked by bHAf in a maturation-dependent fashion at the late OPC (preOL) stage by a noncanonical TLR4/TRIF pathway that induced persistent activation of the FoxO3 transcription factor downstream of AKT...
April 16, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29663922/hyaluronan-based-tumor-targeting-and-ph-responsive-shell-cross-linkable-nanoparticles-for-the-controlled-release-of-doxorubicin
#7
Jianhong Liao, Haoran Zheng, Rui Hu, Jun Cao, Xuan Wei, Dan Li, Hua Zheng, Yihua Yin
In this study, a series of amphiphilic polymeric prodrugs (Azido-functionalized hyaluronan-triazole-imine-doxorubicin, HAimine-DOX) were designed and synthesized by the "Click" reaction with a remarkable grafting ratio of DOX. Nanoparticles with a core-shell structure can be obtained by self-assembling in aqueous media, which exhibited a particle size of 137-170 nm. Moreover, the HA-imine-DOX nanoparticles exhibited good stability in vitro, and the drug release was obviously mediated by the pH gradient...
March 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29661773/integrated-genomic-and-immunophenotypic-classification-of-pancreatic-cancer-reveals-three-distinct-subtypes-with-prognostic-predictive-significance
#8
Martin Wartenberg, Silvia Cibin, Inti Zlobec, Erik Vassella, Serenella M M Eppenberger-Castori, Luigi Terracciano, Micha Eichmann, Mathias Worni, Beat Gloor, Aurel Perren, Eva Karamitopoulou
PURPOSE: Current clinical classification of pancreatic ductal adenocarcinoma (PDAC) is unable to predict prognosis or response to chemo- or immunotherapy and does not take into account the host reaction to PDAC-cells. Our aim is to classify PDAC according to host- and tumor-related factors into clinically/biologically relevant subtypes by integrating molecular and microenvironmental findings. EXPERIMENTAL DESIGN: A well-characterized PDAC-cohort (n=110) underwent next-generation sequencing with a hotspot cancer panel, while Next-generation Tissue-Microarrays were immunostained for CD3, CD4, CD8, CD20, PD-L1, p63, hyaluronan-mediated motility receptor (RHAMM) and DNA mismatch-repair proteins...
April 16, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29658283/-oligo-and-polysacharides-proteoglycans
#9
Lajos Jakab
After clearing up the confusion in the previously used nomenclature, the paper discusses the family of small-leucin-rich glycoproteins. After mentioning the family and its role in the organisation of the ground substance and in the regulation of inflammation, one unique molecule of proteoglycans is presented. This molecule is the inter-α-trypsin inhibitor. It has turned out that this peculiar molecule originally contains glycosaminoglycan beside the neutral carbohydrates. After summarizing the numerous connections of the proteoglycan molecule, the "self-sacrificing" nature of the molecule is presented...
April 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29655990/inorganic-kernel-supported-asymmetric-hybrid-vesicles-for-targeting-delivery-of-stat3-decoy-oligonucleotides-to-overcome-anti-her2-therapeutic-resistance-of-bt474r
#10
Kai Shi, Yan Fang, Shan Gao, Dongjuan Yang, Hongshu Bi, Jianxiu Xue, Anqi Lu, Yuai Li, Liyuan Ke, Xiaojie Lin, Xuechao Jin, Min Li
As a recombinant humanized monoclonal antibody that targets the extracellular region of HER2 tyrosine kinase receptor, trastuzumab (TRAZ) has demonstrated comparable clinical efficacy and improved survival in patients with HER2-positive breast cancer. Nevertheless, the therapeutic potential of TRAZ is often limited due to its frequent resistance to anti-HER2 therapy. Therefore, we investigate the reversal effect of STAT3-specific decoy oligonucleotides (STAT3-decoy ODNs) on TRAZ resistance, which contain the consensus sequence within the targeted gene promoter of STAT3...
April 12, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29650694/lymphatic-vasculature-requires-er-estrogen-receptor-%C3%AE-signaling-to-protect-from-lymphedema
#11
Florent Morfoisse, Florence Tatin, Benoit Chapût, Nicole Therville, Charlotte Vaysse, Raphael Métivier, Julie Malloizel-Delaunay, Francoise Pujol, Anne-Claire Godet, Fabienne De Toni, Frederic Boudou, Katia Grenier, David Dubuc, Eric Lacazette, Anne-Catherine Prats, Julie Guillermet-Guibert, Francoise Lenfant, Barbara Garmy-Susini
OBJECTIVE: Estrogens exert beneficial effect on the blood vascular system. However, their role on the lymphatic system has been poorly investigated. We studied the protective effect of the 17β estradiol-the most potent endogenous estrogen-in lymphedema-a lymphatic dysfunction, which results in a massive fluid and fat accumulation in the limb. APPROACH AND RESULTS: Screening of DNA motifs able to mobilize ERs (estrogen receptors) and quantitative real-time polymerase chain reaction analysis revealed that estradiol promotes transcriptional activation of lymphangiogenesis-related gene expression including VEGF (vascular endothelial growth factor)-D, VEGFR (VEGF receptor)-3, lyve-1, and HASs (hyaluronan synthases)...
April 12, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29642447/mitoq-loaded-chitosan-hyaluronan-composite-membranes-for-wound-healing
#12
Tamer M Tamer, Maurice N Collins, Katarina Valachová, Mohamed A Hassan, Ahmed M Omer, Mohamed S Mohy-Eldin, Karol Švík, Rastislav Jurčík, Ľubomír Ondruška, Csaba Biró, Ahmad B Albadarin, Ladislav Šoltés
Two self-associating biopolymers, namely chitosan (Ch) and a high-molar-mass hyaluronan (HA), were used to prepare membranes with the aim to protect and to enhance the healing of injured skin. A mitochondrially-targeted antioxidant-MitoQ-was incorporated into the mixture of biopolymers prior to their self-association. These three-component membranes were evaluated in detail utilising surface roughness measurements, contact angle measurements, hemocompatibility, and thrombogenicity analyses. Furthermore, in vivo application of Ch/HA/MitoQ membranes was assessed on injured rabbit and rat skin utilizing histological methods...
April 7, 2018: Materials
https://www.readbyqxmd.com/read/29629370/effect-of-co-presentation-of-adhesive-ligands-and-short-hyaluronan-on-lymphendothelial-cells
#13
Christiane H Antoni, Yvonne McDuffie, Jochen Bauer, Jonathan P Sleeman, Heike Boehm
Controlled activation of lymphangiogenesis through functional biomaterials represents a promising approach to support wound healing after surgical procedures, yet remains a challenge. In a synthetic biological approach, we therefore set out to mimic the basal microenvironment of human primary dermal lymphatic endothelial cells (LECs) during lymphangiogenesis. As the extracellular matrix component hyaluronan (HA) regulates lymphangiogenesis, we designed a bifunctional surface in which adhesive peptide ligands and short HA oligosaccharides (sHA) tethered to nanoparticles are copresented to the basal side of LECs in a controlled, concentration-dependent manner...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29628257/atomic-force-microscopy-of-adsorbed-proteoglycan-mimetic-nanoparticles-toward-new-glycocalyx-mimetic-model-surfaces
#14
Mohammadhasan Hedayati, Matt J Kipper
Blood vessels present a dense, non-uniform, polysaccharide-rich layer, called the endothelial glycocalyx. The polysaccharides in the glycocalyx include polyanionic glycosaminoglycans (GAGs). This polysaccharide-rich surface has excellent and unique blood compatibility. We report new methods for preparing and characterizing dense GAG surfaces that can serve as models of the vascular endothelial glycocalyx. The GAG-rich surfaces are prepared by adsorbing heparin or chondroitin sulfate-containing polyelectrolyte complex nanoparticles (PCNs) to chitosan-hyaluronan polyelectrolyte multilayers (PEMs)...
June 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29626161/extracellular-atp-activates-hyaluronan-synthase-2-has2-in-epidermal-keratinocytes-via-p2y-2-ca-2-signaling-and-mapk-pathways
#15
Leena Rauhala, Tiina Jokela, Riikka Kärnä, Geneviève Bart, Piia Takabe, Sanna Oikari, Markku I Tammi, Sanna Pasonen-Seppänen, Raija H Tammi
Extracellular nucleotides are used as signaling molecules by several cell types. In epidermis, their release is triggered by insults such as ultraviolet radiation, barrier disruption and wounding and by specific nerve terminals firing. Increased synthesis of hyaluronan, a ubiquitous extracellular matrix glycosaminoglycan, also occurs in response to stress, leading to the attractive hypothesis that nucleotide signaling and hyaluronan synthesis could also be linked. In HaCaT keratinocytes ATP caused a rapid and strong but transient activation of hyaluronan synthase 2 ( HAS2 ) expression via PKC-, CaMKII-, MAPK- and CREB-dependent pathways by activating the purinergic P2Y2 receptor...
April 6, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29625389/high-molecular-weight-hyaluronan-attenuates-fine-particulate-matter-induced-acute-lung-injury-through-inhibition-of-ros-ask1-p38-jnk-mediated-epithelial-apoptosis
#16
Chenming Xu, Qiwen Shi, Leifang Zhang, Hang Zhao
Inhalation of fine particulate matter (PM2.5 ) is asscoiated with lung injury. High molecular weight hyaluronan (HMW-HA) is an essential constituent of extracellular matrix (ECM), exhibiting anti-oxidative and anti-inflammatory properties when administered by injection, inhalation, nebulization or gene delivery of HA synthases. The aim of the present study is to determine whether HMW-HA alleviates PM2.5 -induced acute lung injury (ALI) and investigate the underlying mechanisms. We observed that HMW-HA suppressed pathological injury, inflammation, oxidative stress, edema and epithelial damage caused by PM2...
March 30, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29625181/hyaluronan-in-immune-dysregulation-and-autoimmune-diseases
#17
REVIEW
Nadine Nagy, Hedwich F Kuipers, Payton L Marshall, Esther Wang, Gernot Kaber, Paul L Bollyky
The tissue microenvironment contributes to local immunity and to the pathogenesis of autoimmune diseases - a diverse set of conditions characterized by sterile inflammation, immunity against self-antigens, and destruction of tissues. However, the specific factors within the tissue microenvironment that contribute to local immune dysregulation in autoimmunity are poorly understood. One particular tissue component implicated in multiple autoimmune diseases is hyaluronan (HA), an extracellular matrix (ECM) polymer...
April 3, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29623978/in-vitro-elucidation-of-the-role-of-pericellular-matrix-in-metastatic-extravasation-and-invasion-of-breast-carcinoma-cells
#18
Marie-Elena Brett, Heather E Bomberger, Geneva R Doak, Matthew A Price, James B McCarthy, David K Wood
Numerous studies have demonstrated the importance of altered hyaluronan metabolism to malignant progression of multiple tumor types, including breast carcinomas. Increased hyaluronan (HA) metabolism in the stroma of primary tumors promotes activation of oncogenic signaling pathways that impact tumor initiation, growth, and invasion. Carcinoma cell synthesis and assembly of HA-rich pericellular matrices induces a stromal-independent phenotype, which is associated with cancer progression. Although the pro-tumorigenic role of stromal HA is well established, a novel but unexplored hypothesis is that carcinoma cell-associated HA pericellular matrices promote metastasis of circulating tumor cells...
April 6, 2018: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/29610929/comp-angiopoietin-1-ameliorates-inflammation-induced-lymphangiogenesis-in-dextran-sulfate-sodium-dss-induced-colitis-model
#19
Ae Sin Lee, Mi Jeong Sung, Won Kim, Yu Jin Jung
Alterations in the intestinal lymphatic network are pathological processes as related to inflammatory bowel disease (IBD). In this study, we demonstrated that reduction in inflammation-induced lymphangiogenesis ameliorates experimental acute colitis. A soluble and stable angiopoietin-1 (Ang1) variant, COMP-Ang1, possesses anti-inflammatory and angiogenic effects. We investigated the effects of COMP-Ang1 on an experimental colonic inflammation model. Experimental colitis was induced in mice by administering 3% dextran sulfate sodium (DSS) via drinking water...
April 2, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29606306/reengineering-the-tumor-vasculature-improving-drug-delivery-and-efficacy
#20
Triantafyllos Stylianopoulos, Lance L Munn, Rakesh K Jain
A solid tumor is like an aberrant organ - comprised of cancer cells and a variety of host cells embedded in an extracellular matrix - nourished by blood vessels and drained by lymphatic vessels. In its journey from the blood stream to cancer cells, a therapeutic agent must cross the vessel wall and the extracellular matrix that cancer cells are ensconced in. Growth of tumors in a confined space along with deposition of matrix components, including collagen (yellow) and hyaluronan (pink), increases 'solid stress', which compresses blood and lymphatic vessels and impairs their function...
April 2018: Trends in Cancer
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