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Ewing sarcoma

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https://www.readbyqxmd.com/read/29050367/expression-and-clinical-association-of-programmed-cell-death-1-programmed-death-ligand-1-and-cd8-lymphocytes-in-primary-sarcomas-is-subtype-dependent
#1
Anke E M van Erp, Yvonne M H Versleijen-Jonkers, Melissa H S Hillebrandt-Roeffen, Laurens van Houdt, Mark A J Gorris, Laura S van Dam, Thomas Mentzel, Marije E Weidema, C Dilara Savci-Heijink, Ingrid M E Desar, Hans H M Merks, Max M van Noesel, Janet Shipley, Winette T A van der Graaf, Uta E Flucke, Friederike A G Meyer-Wentrup
In order to explore the potential of immune checkpoint blockade in sarcoma, we investigated expression and clinical relevance of programmed cell death-1 (PD-1), programmed death ligand-1 (PD-L1) and CD8 in tumors of 208 sarcoma patients. Primary untreated osteosarcoma (n = 46), Ewing sarcoma (n = 32), alveolar rhabdomyosarcoma (n = 20), embryonal rhabdomyosarcoma (n = 77), synovial sarcoma (n = 22) and desmoplastic small round cell tumors (DSRCT) (n = 11) were examined immunohistochemically. PD-L1 expression was predominantly detected in alveolar and embryonal rhabdomyosarcomas (15% and 16%, respectively)...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049915/adult-primary-cervical-extra-osseous-ewing-s-sarcoma-a-case-report-and-short-literature-review
#2
Haytham Eloqayli
INTRODUCTION: Primary spinal epidural extraskeletal Ewing's sarcoma (EES) is extremely rare, with a peak incidence in the second decade of life. EES in old people is challenging to treat due to the lack of specific guidelines. In this paper, I present a unique case of adult primary cervical epidural EES with a 13-month follow-up. A short literature review of the therapeutic approaches and prognosis is also presented. PRESENTATION OF CASE: I present a case of a 49-year old male patient who presented with right upper limb pain, numbness, hand grip weakness, and hyperreflexia of 3 months duration...
October 12, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29045981/renal-ewing-s-sarcoma-primitive-neuroectodermal-tumor-a-case-report-and-literature-review
#3
C Liu, L G Cui, H L Wang
Ewing's sarcoma/primitive neuroectodermal tumor (EWS/PNET) in the kidney is a rare but high-grade malignant tumor that affects predominantly elder children and adolescents. Patients mostly present with nonspecific symptoms such as abdominal pain and gross hematuria. Since EWS/PNET has a rapid clinical progression with early metastasis and death, it is essential to make an accurate and early diagnosis. Once diagnosed, multimodality treatment, including radical surgery combined with adjuvant chemotherapy, and radiotherapy if necessary, is recommended...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29044582/provider-views-on-the-management-of-ewing-sarcoma-of-the-spine-and-pelvis
#4
Chong Zhu, Kristofor A Olson, Michael Roth, David S Geller, Richard G Gorlick, Jonathan Gill, Nadia N Laack, R L Randall
BACKGROUND: Curative therapy for ES requires both chemotherapy and local control of primary tumor. There is no universally accepted standard approach to local control modalities. This survey was conducted to determine practice patterns and factors influencing the choice to offer various local control modalities to patients with ES of the spine and pelvis. METHODS: The survey consisted of four scenarios involving a 15-year-old girl who presented with Ewing sarcoma of thoracic vertebra, sacrum, iliac wing, and acetabulum with or without neurologic compromise...
October 16, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29040902/primary-ewing-s-sarcoma-of-the-kidney-a-case-report
#5
Faris Alasmari, Hani Albadawe, Sultan Alkhateeb, Fahd Alsufiani, Samirah Ghandurah
This is a 15-year-old female who presented with sudden onset left flank pain associated with nausea and vomiting and a history of weight loss. Radiological investigation revealed a large non-obstructive tumor involving the lower pole of the left kidney which was primarily thought to be a renal cell carcinoma. She underwent left open radical nephrectomy with adrenalectomy. Histopathology of the resected specimen showed features of Ewing's sarcoma of the kidney which was confirmed by cytogenetic analysis. This is a rare disease especially in the pediatric group and in reporting such a rare case we hope it helps in identifying a potential course of the disease and its response to the involved treatment...
October 13, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29040875/biomechanical-regulation-of-drug-sensitivity-in-an-engineered-model-of-human-tumor
#6
A Marturano-Kruik, A Villasante, K Yaeger, S R Ambati, A Chramiec, M T Raimondi, G Vunjak-Novakovic
Predictive testing of anticancer drugs remains a challenge. Bioengineered systems, designed to mimic key aspects of the human tumor microenvironment, are now improving our understanding of cancer biology and facilitating clinical translation. We show that mechanical signals have major effects on cancer drug sensitivity, using a bioengineered model of human bone sarcoma. Ewing sarcoma (ES) cells were studied within a three-dimensional (3D) matrix in a bioreactor providing mechanical loadings. Mimicking bone-like mechanical signals within the 3D model, we rescued the ERK1/2-RUNX2 signaling pathways leading to drug resistance...
October 10, 2017: Biomaterials
https://www.readbyqxmd.com/read/29039480/microrna-20b-promotes-cell-proliferation-via-targeting-of-tgf-%C3%AE-receptor-ii-and-upregulates-myc-expression-in-ewing-s-sarcoma-cells
#7
Masanori Kawano, Kazuhiro Tanaka, Ichiro Itonaga, Tatsuya Iwasaki, Hiroshi Tsumura
Transforming growth factor-β receptor II (TGFBR2) is implicated in various types of cancer. Most molecules involved in the TGF-β pathway can be degraded by one or more microRNAs (miRNAs). In the present study, we show that miRNA plays an important role in downregulating TGFBR2 expression in Ewing's sarcoma (ES) cells. Microarray-based analyses revealed that the expression of miR-20b was significantly increased, whereas TGFBR2 and MYC were significantly downregulated and upregulated, respectively, in all ES cells compared to their expression in human mesenchymal stem cells (hMSCs)...
October 12, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29039470/effects-of-baicalein-on-proliferation-apoptosis-migration-and-invasion-of-ewing-s-sarcoma-cells
#8
Conglin Ye, Xiaolong Yu, Jin Zeng, Min Dai, Bin Zhang
Ewing's sarcoma (ES) is a rare tumor that is more frequent in pediatric and adolescent age groups. In the past few decades, long-term survival in affected patients has improved due to the success of multimodal therapy. However, long-term survival is inevitably restricted by the late side-effects of chemotherapy. Besides, early metastasis also contributes to the poor prognosis of ES. Recently, traditional Chinese medicines (TCMs) have increasingly attracted interest due to the promising clinical results and fewer side-effects for the treatment of cancers...
October 10, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29038849/malignant-bone-tumors-other-than-ewing-s-clinical-practice-guidelines-for-diagnosis-treatment-and-follow-up-by-spanish-group-for-research-on-sarcomas-geis
#9
Andrés Redondo, Silvia Bagué, Daniel Bernabeu, Eduardo Ortiz-Cruz, Claudia Valverde, Rosa Alvarez, Javier Martinez-Trufero, Jose A Lopez-Martin, Raquel Correa, Josefina Cruz, Antonio Lopez-Pousa, Aurelio Santos, Xavier García Del Muro, Javier Martin-Broto
Primary malignant bone tumors are uncommon and heterogeneous malignancies. This document is a guideline developed by the Spanish Group for Research on Sarcoma with the participation of different specialists involved in the diagnosis and treatment of bone sarcomas. The aim is to provide practical recommendations with the intention of helping in the clinical decision-making process. The diagnosis and treatment of bone tumors requires a multidisciplinary approach, involving as a minimum pathologists, radiologists, surgeons, and radiation and medical oncologists...
October 16, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29036465/hnrnpm-guides-an-alternative-splicing-program-in-response-to-inhibition-of-the-pi3k-akt-mtor-pathway-in-ewing-sarcoma-cells
#10
Ilaria Passacantilli, Paola Frisone, Elisa De Paola, Marco Fidaleo, Maria Paola Paronetto
Ewing sarcomas (ES) are biologically aggressive tumors of bone and soft tissues for which no cure is currently available. Most ES patients do not respond to chemotherapeutic treatments or acquire resistance. Since the PI3K/AKT/mTOR axis is often deregulated in ES, its inhibition offers therapeutic perspective for these aggressive tumors. Herein, by using splicing sensitive arrays, we have uncovered an extensive splicing program activated upon inhibition of the PI3K/AKT/mTOR signaling pathway by BEZ235. Bioinformatics analyses identified hnRNPM as a key factor in this response...
October 3, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29034595/adamantinoma-like-ewing-sarcoma-of-the-parotid-gland-cytopathologic-findings-and-differential-diagnosis
#11
Mohammed T Lilo, Justin A Bishop, Matthew T Olson, Syed Z Ali
Adamantinoma-like Ewing sarcoma (AES) is a rare variant of Ewing sarcoma family of tumors (EFTs), primarily affecting bone and soft tissue. AES has mixed features of Ewing sarcoma (ES)/primitive neuroectodermal tumor (PNET) and adamantinoma with a complex immunoprofile and EWSR1 gene rearrangements. Herein, we report a 72-year-old male who presented with left parotid mass, right neck mass and thyroid nodules. Fine needle aspiration of the left parotid mass displayed nests of monotonous epithelioid cells with basaloid features in a background of small round blue cells and lymphocytes...
October 16, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29033609/clinical-implications-of-six-inflammatory-biomarkers-as-prognostic-indicators-in-ewing-sarcoma
#12
Yong-Jiang Li, Xi Yang, Wen-Biao Zhang, Cheng Yi, Feng Wang, Ping Li
Cancer-related systemic inflammation responses have been correlated with cancer development and progression. The prognostic significance of several inflammatory indicators, including neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), Glasgow Prognostic Score (GPS), C-reactive protein to albumin ratio (CRP/Alb ratio), lymphocyte-monocyte ratio (LMR), and neutrophil-platelet score (NPS), were found to be correlated with prognosis in several cancers. However, the prognostic role of these inflammatory biomarkers in Ewing sarcoma has not been evaluated...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/29022407/the-potential-of-kdm3a-as-a-therapeutic-target-in-ewing-sarcoma-and-other-cancers
#13
Paul Jedlicka
No abstract text is available yet for this article.
October 12, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/29016412/false-lung-metastasis-concurrent-ewing-sarcoma-and-minimally-invasive-adenocarcinoma
#14
Allison S Bechtel, Bradley Cheek, Scott Bradfield
Pediatric lung cancer is a very rare occurrence, particularly as a primary lesion. A concurrent diagnosis is even more unusual and only reported a handful of times in Ewing sarcoma. Our patient is a 13-year-old boy who had concurrent diagnoses of Ewing sarcoma and minimally invasive adenocarcinoma of the lung, formerly bronchoalveolar carcinoma. To our knowledge this has also been found in at least 1 other case. There are some classic genetic mutations associated with Ewing sarcoma. None have been found to be linked with the concurrent diagnosis...
October 9, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28994872/primary-ewing-s-sarcoma-of-the-sphenoid-sinus-with-orbital-and-intracranial-extension-a-case-report
#15
Senda Turki, Skander Kedous, Madiha Mahjoubi, Sawssen Dhambri, Zied Attia, Slim Touati
Ewing's sarcoma is a high-grade neuroectodermal primary bone tumor. This is the second primary bone tumor in children afterosteosarcoma and represents 4 to10% of cases. It can occur in all skeletal bones. However, the location at the facial bones is uncommon (1to2%) and extremely rare at the sphenoid sinus. We report the clinical results of a rare case of Ewing's sarcoma of the sphenoid with intraorbitaland intracranial extension.
November 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28988646/pembrolizumab-in-advanced-soft-tissue-sarcoma-and-bone-sarcoma-sarc028-a-multicentre-two-cohort-single-arm-open-label-phase-2-trial
#16
Hussein A Tawbi, Melissa Burgess, Vanessa Bolejack, Brian A Van Tine, Scott M Schuetze, James Hu, Sandra D'Angelo, Steven Attia, Richard F Riedel, Dennis A Priebat, Sujana Movva, Lara E Davis, Scott H Okuno, Damon R Reed, John Crowley, Lisa H Butterfield, Ruth Salazar, Jaime Rodriguez-Canales, Alexander J Lazar, Ignacio I Wistuba, Laurence H Baker, Robert G Maki, Denise Reinke, Shreyaskumar Patel
BACKGROUND: Patients with advanced sarcomas have a poor prognosis and few treatment options that improve overall survival. Chemotherapy and targeted therapies offer short-lived disease control. We assessed pembrolizumab, an anti-PD-1 antibody, for safety and activity in patients with advanced soft-tissue sarcoma or bone sarcoma. METHODS: In this two-cohort, single-arm, open-label, phase 2 study, we enrolled patients with soft-tissue sarcoma or bone sarcoma from 12 academic centres in the USA that were members of the Sarcoma Alliance for Research through Collaboration (SARC)...
October 4, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28986639/-postoperative-and-posttherapeutic-changes-after-primary-bone-tumors-what-s-important-for-radiologists
#17
REVIEW
T Grieser, I-M Nöbauer-Huhmann
Posttreatment imaging of primary bone tumours represents a diagnostic challenge for radiologists. Depending on the primary bone tumour common radiological procedures, such as radiography, computed tomography (CT), and magnetic resonance imaging (MRI), are employed. Radiography and CT are particularly useful in benign bone tumours and in matrix-forming bone tumours. MRI comes into consideration with malignant tumour recurrence and tumoral soft tissue infiltration. Bone scintigraphy is of superior importance if a primarily multifocal manifestation of bone tumour or metastasizing tumour disease is suspected...
October 6, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28985030/a-double-edged-sword-the-world-according-to-capicua-in-cancer
#18
REVIEW
Miwa Tanaka, Toyoki Yoshimoto, Takuro Nakamura
CIC/Capicua is a HMG-box transcription factor that is well conserved during evolution. CIC recognizes the T(G/C)AATG(A/G)A sequence and represses its target genes such as PEA3 family genes. The RTK/RAS/MAPK signals downregulate CIC and relieves CIC's target genes from the transrepressional activity, and CIC thus acts as an important downstream molecule of the pathway and as a tumor suppressor. CIC loss-of-function mutations are frequently observed in several human neoplasms such as oligodendroglioma, and lung and gastric carcinoma...
October 6, 2017: Cancer Science
https://www.readbyqxmd.com/read/28974650/inhibition-of-the-oncogenic-fusion-protein-ews-fli1-causes-g2-m-cell-cycle-arrest-and-enhanced-vincristine-sensitivity-in-ewing-s-sarcoma
#19
Stefan K Zöllner, Saravana P Selvanathan, Garrett T Graham, Ryan M T Commins, Sung Hyeok Hong, Eric Moseley, Sydney Parks, Jessica N Haladyna, Hayriye V Erkizan, Uta Dirksen, Michael D Hogarty, Aykut Üren, Jeffrey A Toretsky
Ewing's sarcoma (ES) is a rare and highly malignant cancer that grows in the bones or surrounding tissues mostly affecting adolescents and young adults. A chimeric fusion between the RNA binding protein EWS and the ETS family transcription factor FLI1 (EWS-FLI1), which is generated from a chromosomal translocation, is implicated in driving most ES cases by modulation of transcription and alternative splicing. The small-molecule YK-4-279 inhibits EWS-FLI1 function and induces apoptosis in ES cells. We aimed to identify both the underlying mechanism of the drug and potential combination therapies that might enhance its antitumor activity...
October 3, 2017: Science Signaling
https://www.readbyqxmd.com/read/28965545/pet-ct-of-osteosarcoma-and-ewing-sarcoma
#20
Colleen M Costelloe, Hubert H Chuang, Najat C Daw
No abstract text is available yet for this article.
October 2017: Seminars in Roentgenology
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