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https://www.readbyqxmd.com/read/29931504/growing-role-of-regorafenib-in-the-treatment-of-patients-with-sarcoma
#1
Mark Agulnik, Steven Attia
Sarcomas encompass a group of rare solid tumors responsible for approximately 1% of all cancer-related deaths in the United States each year. Subtypes include, but are not limited to, soft tissue sarcomas (STS) such as leiomyosarcoma, liposarcoma, pleomorphic sarcoma, and gastrointestinal stromal tumor (GIST). Treatment options for patients with STS vary depending on, among other factors, histological subtype. Data from a mix of phase 2 and phase 3 trials have suggested that the orally available multikinase inhibitor regorafenib may have efficacy in patients with STS who have progressed on previous lines of systemic therapy...
June 21, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/29928349/kdm3a-is-not-associated-with-metastasis-and-prognosis-of-breast-cancer
#2
Juan Yao, Shutao Zheng, Baiyan Li, Xinxin Li, Wenya Liu
Lysine demethylase 3A (KDM3A), also known as JMJD1A, has been associated with metastasis and poor prognosis in several cancer types, including renal cell carcinoma, prostate cancer and Ewing sarcoma. However, little is known regarding the clinicopathological significance of KDM3A expression in breast cancer (BCa). To investigate the clinical relevance of KDM3A expression in the setting of BCa, immunohistochemistry was performed on a tissue microarray consisting of 150 commercially available BCa samples. No significant correlation was identified between KDM3A expression and various clinicopathological variables, including clinical stage, pathological grade, tumor size and the expression statuses of human epidermal growth factor receptor 2, estrogen receptor, and progesterone receptor...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29920735/pax7-immunohistochemical-evaluation-of-ewing-sarcoma-and-other-small-round-cell-tumors
#3
Shunichi Toki, Susumu Wakai, Masaya Sekimizu, Taisuke Mori, Hitoshi Ichikawa, Akira Kawai, Akihiko Yoshida
AIMS: Ewing sarcoma is a small round cell tumor that affects bone and soft tissues. Although the detection of the specific fusion gene is a robust method of its diagnosis, immunohistochemistry may serve as a practical surrogate. Recent tissue microarray studies suggested that PAX7 is a novel marker, because it was consistently expressed in Ewing sarcoma, in addition to rhabdomyosarcoma and synovial sarcoma. Here, we evaluated the utility of PAX7 immunohistochemistry in whole-tissue sections of an expanded array of round cell malignancies with adequate molecular characterization...
June 19, 2018: Histopathology
https://www.readbyqxmd.com/read/29911999/ewing-sarcoma-and-the-history-of-similar-and-possibly-related-small-round-cell-tumors-from-whence-have-we-come-and-where-are-we-going
#4
Scott E Kilpatrick, John D Reith, Brian Rubin
The diagnosis of small round cell tumors always has been extremely difficult, and our current classification systems continue to evolve. Since its initial discovery by Dr James Ewing, the historical context of what is acceptably included under the designation "Ewing sarcoma" has changed. Although Ewing sarcoma and primitive neuroectodermal tumor were both initially described in the early 20th century, these tumors were considered likely distinct entities until the end of that same century, almost 75 years later...
June 14, 2018: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/29905027/increased-risk-of-bone-tumors-after-growth-hormone-treatment-in-childhood-a-population-based-cohort-study-in-france
#5
Amélie Poidvin, Jean-Claude Carel, Emmanuel Ecosse, Dominique Levy, Jean Michon, Joël Coste
The association between growth hormone (GH) treatment and cancer risk has not been thoroughly evaluated and there are questions about any increased risk of bone tumors. We examined cancer risk and especially bone tumor risk in a population-based cohort study of 6874 patients treated with recombinant GH in France for isolated GH deficiency, short stature associated with low birth weight or length or idiopathic short stature. Adult mortality and morbidity data obtained from national databases and from questionnaires...
June 14, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29904746/saving-the-hand-role-of-multimodality-therapy-for-ewing-s-sarcoma-family-tumor-of-the-palm
#6
Sanjay A Joseph, Rahul Bhandari, Ashley Albert, James Jackson, Madhava Kanakamedala, Robert D Hamilton, Jennifer Barr, Srinivasan Vijayakumar
No abstract text is available yet for this article.
April 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29904480/peripheral-primitive-neuroendocrine-tumor-of-the-chest-wall-a-case-report-with-pathological-correlation
#7
Jidi Gao, Erika Chow, Aishatu Aloma, Payal Gupta
Primitive neuroectodermal tumor is a high-grade malignant tumor originating from the neural crest and neuroectoderm, which can be subdivided into central and peripheral categories. Peripheral primitive neuroectodermal tumor is thought to be identical to Ewing's sarcoma, and falls under a broader category of Ewing's sarcoma family of tumors. Very rarely, it may present without osseous involvement, known as extraosseous Ewing's sarcoma. Here we present a case of a 38-year-old woman, who presented with several-month history of a slow-growing chest wall mass, initially thought to be a breast mass...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29899761/precision-diagnostics-of-ewing-s-sarcoma-by-liquid-biopsy-circulating-ews-fli1-fusion-transcripts
#8
Matteo Allegretti, Beatrice Casini, Chiara Mandoj, Stefania Benini, Laurent Alberti, Mariangela Novello, Elisa Melucci, Laura Conti, Renato Covello, Edoardo Pescarmona, Giuseppe Maria Milano, Alessio Annovazzi, Vincenzo Anelli, Virginia Ferraresi, Roberto Biagini, Patrizio Giacomini
Background: Limited information is available on the applicative value of liquid biopsy (LB) in rare tumors, including Ewing's sarcoma (ES). The accepted precision diagnostics standards would greatly benefit from a non-invasive LB test monitoring pathognomonic gene rearrangements in the bloodstream. Methods: Tissue and blood samples were collected from six and four ES patients, respectively. Plasma was cleared by two successive rounds of centrifugation and stored frozen until RNA extraction by the QIAmp CNA kit...
2018: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/29898995/ews-ets-driven-ewing-sarcoma-requires-bet-bromodomain-proteins
#9
Paradesi Naidu Gollavilli, Aishwarya Pawar, Kari Wilder-Romans, Natesan Ramakrishnan, Carl G Engelke, Vijaya L Dommeti, Pranathi M Krishnamurthy, Archana Nallasivam, Ingrid J Apel, Tianlei Xu, Zhaohui Qin, Felix Y Feng, Irfan A Asangani
The EWS/ETS fusion transcription factors drive Ewing sarcoma (EWS) by orchestrating an oncogenic transcription program. Therapeutic targeting of EWS/ETS has been unsuccessful; however, identifying mediators of the EWS/ETS function could offer new therapeutic options. Here we describe the dependency of EWS/ETS-driven transcription upon chromatin reader BET bromdomain proteins and investigate the potential of BET inhibitors in treating EWS. EWS/FLI1 and EWS/ERG were found in a transcriptional complex with BRD4, and knockdown of BRD2/3/4 significantly impaired the oncogenic phenotype of EWS cells...
June 13, 2018: Cancer Research
https://www.readbyqxmd.com/read/29895547/metachronous-renal-ewing-sarcoma-primitive-neuroectodermal-tumour-in-a-survivor-of-burkitt-lymphoma
#10
Kumail Khandwala, Kiran Hilal, Zehra Fadoo, Khurram Minhas
We present a case of a 14-year-old girl who was diagnosed with Burkitt lymphoma in 2014. She was managed with chemotherapy and remained in remission for 3 years. On her surveillance imaging in 2017, a left-sided renal neoplastic mass was incidentally discovered. She underwent nephrectomy and pathology of the resected specimen revealed small cell tumour of the kidney with features favouring renal Ewing sarcoma/primitive neuroectodermal tumour. Molecular genetic analysis by fluorescence in situ hybridisation was performed which showed translocation of 22q12, thereby confirming the diagnosis...
June 11, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29895220/chemokine-expression-is-involved-in-the-vascular-neogenesis-of-ewing-sarcoma-a-preliminary-analysis-of-the-early-stages-of-angiogenesis-in-a-xenograft-model
#11
Francisco Giner, José A López-Guerrero, Antonio Fernández-Serra, Isidro Machado, Empar Mayordomo-Aranda, Amando Peydró-Olaya, Antonio Llombart-Bosch
Background Ewing sarcoma (EWS) is the second most common bone cancer in pediatric patients. Angiogenesis is a major factor for tumor growth and metastasis. Our aim was to carry out a histological, immunohistochemical, and molecular characterization of the neovascularization established between xenotransplanted tumors and the host during the initial phases of growth in nude mice in three angiogenesis experiments (ES2, ES3, and ES4). Methods The original human EWS were implanted subcutaneously on the backs of three nude mice...
January 1, 2018: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/29892999/tissue-compatibility-of-sn-38-loaded-anticancer-nanofiber-matrices
#12
Alejandro Manzanares, Camilo A Restrepo-Perdomo, Gaia Botteri, Helena Castillo-Ecija, Guillem Pascual-Pasto, Francesc Cano, Laura Garcia-Alvarez, Carles Monterrubio, Bonaventura Ruiz, Manuel Vazquez-Carrera, Mariona Suñol, Jaume Mora, Jose A Tornero, Alejandro Sosnik, Angel M Carcaboso
Delivery of chemotherapy in the surgical bed has shown preclinical activity to control cancer progression upon subtotal resection of pediatric solid tumors, but whether this new treatment is safe for tumor-adjacent healthy tissues remains unknown. Here, Wistar rats are used to study the anatomic and functional impact of electrospun nanofiber matrices eluting SN-38-a potent chemotherapeutic agent-on several body sites where pediatric tumors such as neuroblastoma, Ewing sarcoma, and rhabdomyosarcoma arise. Blank and SN-38-loaded matrices embracing the femoral neurovascular bundle or in direct contact with abdominal viscera (liver, kidney, urinary bladder, intestine, and uterus) are placed...
June 11, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29891750/ewing-sarcoma-peripheral-primitive-neuroectodermal-tumor-in-the-adrenal-gland-of-a-child
#13
Kourosh Goudarzipour, Farzaneh Farahmandi, Ahmad Mohammadi, Reza Taherian
Ewing sarcoma/peripheral primitive neuroectodermal tumor (ES/PNET) typically occurs in long or flat bones, soft tissues, or less often, solid organs. Ewing sarcoma/peripheral primitive neuroectodermal tumor arising from the adrenal gland is extremely rare, especially in children, and only limited cases are reported previously. Herein, we review a case of a 22-month-old girl who presented to our department with abdominal pain, bulging of the left flank, and a nonfunctioning adrenal lesion which was found to be an adrenal ES/PNET...
May 2018: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29881715/an-update-from-the-pediatric-proton-consortium-registry
#14
Clayton B Hess, Daniel J Indelicato, Arnold C Paulino, William F Hartsell, Christine E Hill-Kayser, Stephanie M Perkins, Anita Mahajan, Nadia N Laack, Ralph P Ermoian, Andrew L Chang, Suzanne L Wolden, Victor S Mangona, Young Kwok, John C Breneman, John P Perentesis, Sara L Gallotto, Elizabeth A Weyman, Benjamin V M Bajaj, Miranda P Lawell, Beow Y Yeap, Torunn I Yock
Background/objectives: The Pediatric Proton Consortium Registry (PPCR) was established to expedite proton outcomes research in the pediatric population requiring radiotherapy. Here, we introduce the PPCR as a resource to the oncology community and provide an overview of the data available for further study and collaboration. Design/methods: A multi-institutional registry of integrated clinical, dosimetric, radiographic, and patient-reported data for patients undergoing proton radiation therapy was conceived in May 2010...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29880247/development-and-current-use-of-in-hematopoietic-stem-cell-transplantation-in-children-and-adolescents-in-poland-report-of-the-polish-pediatric-study-group-for-hematopoietic-stem-cell-transplantation-of-the-polish-society-for-pediatric-oncology-and-hematology
#15
REVIEW
Jacek Wachowiak, Alicja Chybicka, Jerzy R Kowalczyk, Mariusz Wysocki, Jolanta Goździk, Ewa Gorczyńska, Krzysztof Kałwak, Jan Styczyński, Katarzyna Drabko, Anna Pieczonka
The purpose of the survey was to evaluate the development and current use of hematopoietic stem cell transplantation (HSCT) in Poland between 1989-2016. The data for analysis (indication, number of performed HSCT, HSCT type, donor type, and stem cell source, year) have been collected annually using a standardized form. In Poland, between 1989-2016, the number of pediatric transplant beds grew from one to 40 and number and rate of transplants increased annually from 1/year (0.8/10 million) to 186/year (248/10 million)...
May 16, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29873416/ews-fli1-reprograms-the-metabolism-of-ewing-sarcoma-cells-via-positive-regulation-of-glutamine-import-and-serine-glycine-biosynthesis
#16
Nirmalya Sen, Allison M Cross, Philip L Lorenzi, Javed Khan, Berkley E Gryder, Suntae Kim, Natasha J Caplen
Ewing sarcoma (EWS) is a soft tissue and bone tumor that occurs primarily in adolescents and young adults. In most cases of EWS, the chimeric transcription factor, EWS-FLI1 is the primary oncogenic driver. The epigenome of EWS cells reflects EWS-FLI1 binding and activation or repression of transcription. Here, we demonstrate that EWS-FLI1 positively regulates the expression of proteins required for serine-glycine biosynthesis and uptake of the alternative nutrient source glutamine. Specifically, we show that EWS-FLI1 activates expression of PHGDH, PSAT1, PSPH, and SHMT2...
June 6, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29865280/preclinical-testing-of-an-oncolytic-parvovirus-in-ewing-sarcoma-protoparvovirus-h-1-induces-apoptosis-and-lytic-infection-in-vitro-but-fails-to-improve-survival-in-vivo
#17
Jeannine Lacroix, Zoltán Kis, Rafael Josupeit, Franziska Schlund, Alexandra Stroh-Dege, Monika Frank-Stöhr, Barbara Leuchs, Jörg R Schlehofer, Jean Rommelaere, Christiane Dinsart
About 70% of all Ewing sarcoma (EWS) patients are diagnosed under the age of 20 years. Over the last decades little progress has been made towards finding effective treatment approaches for primarily metastasized or refractory Ewing sarcoma in young patients. Here, in the context of the search for novel therapeutic options, the potential of oncolytic protoparvovirus H-1 (H-1PV) to treat Ewing sarcoma was evaluated, its safety having been proven previously tested in adult cancer patients and its oncolytic efficacy demonstrated on osteosarcoma cell cultures...
June 3, 2018: Viruses
https://www.readbyqxmd.com/read/29864558/cervical-gibbectomy-for-rigid-rounded-kyphosis-in-a-pediatric-patient-surgical-planning-with-technical-note
#18
Kunal C Shah, Akshay Gadia, Uday Pawar, Abhay Nene
OBJECTIVES: Cervical kyphosis surgery poses significant challenge to the spine surgeons. Etiologies of cervical kyphosis are many, each having its own outcome and treatment challenges. Irrespective of the etiology, the treating physician should consider all options fully to improve function and prevent neurological worsening. We outline management principles and decision-making in case of rigid rounded kyphosis of cervical spine and highlight the technique of the internal gibbectomy procedure, which is never reported in cervical spine METHODS: We report a case of Ewing's sarcoma of cervical spine that presented with progressive myelopathy symptoms...
June 1, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29851332/-application-of-three-dimensional-printing-technology-in-bone-tumor-surgery
#19
Leilei Xu, Zheng Tian, Akbar Yunus, Xiaoshuai Wang, Jiangtao Chen, Chong Wang, Xinghua Song
Objective: To discuss the effect of three-dimensional (3D) printing individualized model and guide plate in bone tumor surgery. Methods: Between October 2015 and December 2016, 3D printing individualized model and guide plate for making preoperative surgical planning and intraoperative treatment were used in 5 patients of bone tumor. All the patients were male, with a median age of 32 years (range, 9-58 years). There were 1 case of cystic echinococcosis at left pelvis and pathological fracture of the proximal femur; 1 case of left iliac bone osteoblastoma associated with aneurysmal bone cyst; 1 case of fibrous dysplasia of the left femur (sheep horn deformity) with pathological fracture; 1 case of metastatic carcinoma of right calcaneus (tumor staging was T 2 N 0 M 0 ); and 1 case of Ewing sarcoma of left femur (tumor staging was T 2 N 0 M 0 )...
September 1, 2017: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29850398/small-animal-models-for-the-study-of-bone-sarcoma-pathogenesis-characteristics-therapeutic-interests-and-limitations
#20
REVIEW
Camille Jacques, Nathalie Renema, Frederic Lezot, Benjamin Ory, Carl R Walkley, Agi E Grigoriadis, Dominique Heymann
Osteosarcoma, Ewing sarcoma and chondrosarcoma are the three main entities of bone sarcoma which collectively encompass more than 50 heterogeneous entities of rare malignancies. In contrast to osteosarcoma and Ewing sarcoma which mainly affect adolescents and young adults and exhibit a high propensity to metastasise to the lungs, chondrosarcoma is more frequently observed after 40 years of age and is characterised by a high frequency of local recurrence. The combination of chemotherapy, surgical resection and radiotherapy has contributed to an improved outcome for these patients...
September 2018: Journal of Bone Oncology
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