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https://www.readbyqxmd.com/read/28230765/metabolic-effects-of-glucose-fructose-co-ingestion-compared-to-glucose-alone-during-exercise-in-type-1-diabetes
#1
Lia Bally, Patrick Kempf, Thomas Zueger, Christian Speck, Nicola Pasi, Carlos Ciller, Katrin Feller, Hannah Loher, Robin Rosset, Matthias Wilhelm, Chris Boesch, Tania Buehler, Ayse S Dokumaci, Luc Tappy, Christoph Stettler
This paper aims to compare the metabolic effects of glucose-fructose co-ingestion (GLUFRU) with glucose alone (GLU) in exercising individuals with type 1 diabetes mellitus. Fifteen male individuals with type 1 diabetes (HbA1c 7.0% ± 0.6% (53 ± 7 mmol/mol)) underwent a 90 min iso-energetic continuous cycling session at 50% VO2max while ingesting combined glucose-fructose (GLUFRU) or glucose alone (GLU) to maintain stable glycaemia without insulin adjustment. GLUFRU and GLU were labelled with (13)C-fructose and (13)C-glucose, respectively...
February 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28229636/exercise-partially-reverses-the-inhibitory-effect-of-caffeine-on-liver-gluconeogenesis-in-type-1-diabetic-rats-with-hypoglycemia
#2
E H Gilglioni, C M Ghuidotti, V R Vilela, C Bataglini, J P Furlan, J A Berti, Mmd Pedrosa, Vaf Godoi
The purpose was to determine the possible effects of exercise and/or caffeine on hypoglycemia and liver gluconeogenesis in diabetic rats. These were divided into four subgroups: (a) intraperitoneal insulin only, (b) exercise bout before insulin, (c) caffeine after insulin, and (d) exercise bout before and caffeine after insulin. The marked glycemic drop 45 min after insulin (0 min = 229.00, 45 min = 75.75) was considerably reduced (p < 0.05) by caffeine or exercise (45 min: exercise = 127...
September 2016: Physiol Int
https://www.readbyqxmd.com/read/28229629/protective-effect-of-crocin-and-voluntary-exercise-against-oxidative-stress-in-the-heart-of-high-fat-diet-induced-type-2-diabetic-rats
#3
V Ghorbanzadeh, M Mohammadi, G Mohaddes, H Dariushnejad, L Chodari, S Mohammadi
Background Oxidative stress plays a critical role in the pathogenesis and progression of type 2 diabetes and diabetic-associated cardiovascular complications. This study investigated the impact of crocin combined with voluntary exercise on heart oxidative stress indicator in high-fat diet-induced type 2 diabetic rats. Materials and methods Rats were divided into four groups: diabetes, diabetic-crocin, diabetic-voluntary exercise, diabetic-crocin-voluntary exercise. Type 2 diabetes was induced by high-fat diet (4 weeks) and injection of streptozotocin (intraperitoneally, 35 mg/kg)...
December 2016: Physiol Int
https://www.readbyqxmd.com/read/28227217/acceptability-of-a-team-based-mobile-health-mhealth-application-for-lifestyle-self-management-in-individuals-with-chronic-illnesses
#4
Andrea L Hartzler, Anusha Venkatakrishnan, Shiwali Mohan, Michael Silva, Paula Lozano, James D Ralston, Evette Ludman, Dori Rosenberg, Katherine M Newton, Lester Nelson, Peter Pirolli, Andrea L Hartzler, Anusha Venkatakrishnan, Shiwali Mohan, Michael Silva, Paula Lozano, James D Ralston, Evette Ludman, Dori Rosenberg, Katherine M Newton, Lester Nelson, Peter Pirolli, Dori Rosenberg, James D Ralston, Evette Ludman, Katherine M Newton, Lester Nelson, Anusha Venkatakrishnan, Shiwali Mohan, Michael Silva, Paula Lozano, Peter Pirolli, Andrea L Hartzler
With increased incidence of chronic illnesses arising due to unhealthy lifestyle habits, it is increasingly important to leverage technology applications to promote and sustain health behavior change. We developed a smartphone-based application, NutriWalking (NW), which recommends personalized daily exercise goals and promotes healthy nutritional habits in small peer teams. Here, we demonstrate an early study of usability and acceptability of this app in patients with type 2 Diabetes Mellitus and Depression...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226972/design-of-a-dual-hormone-model-predictive-control-for-artificial-pancreas-with-exercise-model
#5
Navid Resalat, Joseph El Youssef, Ravi Reddy, Peter G Jacobs, Navid Resalat, Joseph El Youssef, Ravi Reddy, Peter G Jacobs, Navid Resalat, Joseph El Youssef, Peter G Jacobs, Ravi Reddy
The Artificial Pancreas (AP) is a new technology for helping people with type 1 diabetes to better control their glucose levels through automated delivery of insulin and optionally glucagon in response to sensed glucose levels. In a dual hormone AP, insulin and glucagon are delivered automatically to the body based on glucose sensor measurements using a control algorithm that calculates the amount of hormones to be infused. A dual-hormone MPC may deliver insulin continuously; however, it must avoid continuous delivery of glucagon because nausea can occur from too much glucagon...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28217526/the-rule-of-two-thirds-in-diabetes-epidemiology
#6
Sanjay Kalra, Banshi Saboo, Rakesh Sahay, Deepak Khandelwal, Vipin Talwar, A G Unnikrishnan
This communication hypothesises a rule of two thirds which seems to operate in Indian diabetes epidemiology. Two thirds of all persons with dysglycemia are prediabetic; two thirds of all persons with diabetes are diagnosed to have the condtion; and two thirds are diagnosed before the age of 50 years. Two thirds of people with diabetes have concomitant hypetension or dyslipidemia; two thirds do not get their HbA1c assessed; and two thirds of those who do, do not achiev target values. Yet, two thirds of people with diabetes report satisfactory psychosocial health and quality of life, and adherence to dietary therapy and medication...
January 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28215975/physical-activity-and-cardiovascular-prevention-is-healthy-urban-living-a-possible-reality-or-utopia
#7
REVIEW
Silvio Buscemi, Carla Giordano
Favoring correct lifestyles is the most important measure to contrast cardiovascular diseases and the epidemic of high cardiovascular risk conditions, such as obesity, diabetes, and hypertension. Lifestyle is a broad expression that includes diet, physical exercise, and psychological and socio-economic factors, each of which must be taken into due consideration because of their intertwining influences, which may be a barrier to healthy changes at both the individual and population levels. While physical activity has probably received less attention in the last decades, it is likely the most important among the modifiable risk factors for cardiovascular diseases...
February 16, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28214792/suppression-of-tumorigenicity-2-in-heart-failure-with-preserved-ejection-fraction
#8
Omar F AbouEzzeddine, Paul M McKie, Shannon M Dunlay, Susanna R Stevens, G Michael Felker, Barry A Borlaug, Horng H Chen, Russell P Tracy, Eugene Braunwald, Margaret M Redfield
BACKGROUND: Soluble suppression of tumorigenicity 2 (sST2) receptor is a biomarker that is elevated in certain systemic inflammatory diseases. Comorbidity-driven microvascular inflammation is postulated to play a key role in heart failure with preserved ejection fraction (HFpEF) pathophysiology, but data on how sST2 relates to clinical characteristics or inflammatory conditions or biomarkers in HFpEF are limited. We sought to determine circulating levels and clinical correlates of sST2 in HFpEF...
February 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28212346/the-relationship-between-physical-activity-and-plasma-glucose-level-amongst-ellisras-rural-young-adult-males-and-females-ellisras-longitudinal-study
#9
Moloko Matshipi, Kotsedi Daniel Monyeki, Han Kemper
Unhealthy lifestyle characteristics such as low physical activity (PA) and high plasma glucose levels (PGLs) may lead to the development of type 2 diabetes mellitus in adulthood. The aim of this study was to investigate (i) the level of physical activity; (ii) the prevalence of pre-diabetes and (iii) the relationship between PA and plasma glucose level in a rural Ellisras adult population aged 18 to 28 years. A total of 713 young adults (349 males and 364 females) who took part in the Ellisras Longitudinal Study participated in the study...
February 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28210986/the-role-of-the-pharmacist-in-managing-type-2-diabetes-with-glucagon-like-peptide-1-receptor-agonists-as-add-on-therapy
#10
REVIEW
Jerry Meece
: The prevalence and associated clinical burden of type 2 diabetes (T2D) is increasing in the USA and other countries. As a consequence, the role of the pharmacist in managing T2D is expanding, and it is becoming increasingly important for pharmacists to have a complete understanding of the disease course and treatment options. Pharmacists have a key role in the use of injectable therapies, including incretin-based treatment with glucagon-like peptide-1 receptor agonists (GLP-1RAs). This article discusses the role of the pharmacist in the management of patients with T2D, particularly with respect to the use of GLP-1RAs to achieve glycemic control...
February 16, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28210043/repeated-3-minute-stair-climbing-descending-exercise-after-a-meal-over-2-weeks-increases-serum-1-5-anhydroglucitol-levels-in-people-with-type-2-diabetes
#11
Hiroto Honda, Makoto Igaki, Yuki Hatanaka, Motoaki Komatsu, Shin-Ichiro Tanaka, Tetsuo Miki, Yumika Matsuki, Tetsuo Takaishi, Tatsuya Hayashi
[Purpose] The purpose of this study was to examine the hypoglycemic effect of a postprandial exercise program using brief stair climbing-descending exercise in people with type 2 diabetes. [Subjects and Methods] Seven males with uncomplicated type 2 diabetes (age 68.0 ± 3.7 years) performed two sets of stair climbing-descending exercise 60 and 120 min after each meal for the first 2 weeks but not for the following 2 weeks. Each set of exercise comprised 3-min of continuous repetition of climbing briskly to the second floor followed by slow waking down to the first floor in their home...
January 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28210013/the-relation-between-depressive-symptoms-and-self-care-in-patients-with-diabetes-mellitus-type-2-in-kosovo
#12
Idriz Sopjani, Shemsedin Vehapi, Daut Gorani, Miradije Imeri, Sidita Vitoja, Shqipe Tahiri
BACKGROUND: The depression is a significant problem in patients with diabetes. This research is the first of it's kind conducted in the Republic of Kosovo to determine the prevalence of depression diagnosed in people with diabetes mellitus type 2 (DMT2) and interrelation between depressive symptoms and behavior of diabetes self-care (glucose monitoring, exercise, diet, and self- health care). METHODS: Research was conducted in the University Clinical Center of Kosovo (UCCK), in Pristine...
December 2016: Medical Archives
https://www.readbyqxmd.com/read/28209386/dietary-therapy-in-heart-failure-with-preserved-ejection-fraction-and-or-left-ventricular-diastolic-dysfunction-in-patients-with-metabolic-syndrome
#13
REVIEW
Helene von Bibra, Alexander Ströhle, Martin St John Sutton, Nicolai Worm
BACKGROUND: Heart failure is an ongoing epidemic of left ventricular (LV) dilatation and/or dysfunction due to the increasing prevalence of predisposing risk factors such as age, physical inactivity, (abdominal) obesity, and type-2-diabetes. Approximately half of these patients have diastolic heart failure (HFpEF). The prognosis of HFpEF is comparable to that of systolic heart failure, but without any known effective treatment. DIASTOLIC DYSFUNCTION: A biomathematically corrected diagnostic approach is presented that quantifies diastolic dysfunction via the predominant age dependency of LV diastolic function and unmasks (metabolic) risk factors, that are independent of age and, therefore, potential targets for therapy...
January 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28208021/exercise-timing-and-blood-lactate-concentrations-in-individuals-with-type-2-diabetes
#14
Timothy D Heden, Ying Liu, Jill A Kanaley
The purpose of this study was to characterize how resistance exercise prior to or after a meal alters fasting and postprandial blood lactate concentrations in individuals with type 2 diabetes. Obese individuals with type 2 diabetes (N=12) completed three, 2-d trials including: 1) no exercise (NoEx), 2) resistance exercise prior to dinner (Ex-M), and 3) resistance exercise beginning 45-min postdinner (M-Ex). During day one of each trial fasting and postprandial blood lactate concentrations, perceived exertion, and substrate oxidation were measured, and subsequently on day two the following morning fasting blood lactate was measured...
February 16, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28205324/evaluation-of-subcutaneous-glucose-monitoring-systems-under-routine-environmental-conditions-in-patients-with-type-1-diabetes
#15
Felix Aberer, Martin Hajnsek, Markus Rumpler, Sabine Zenz, Petra Baumann, Hesham Elsayed, Adelheid Puffing, Gerlies Treiber, Thomas R Pieber, Harald Sourij, Julia K Mader
: Continuous and flash glucose monitoring (GM) systems have been established in diabetes care. We compared sensor performance of three commercially available GM systems. 12 patients with type 1 diabetes were included in a single-centre, open-label study where sensor performance of Abbott FreeStyle libre (Abbott), Dexcom G4 Platinum (Dexcom) and Medtronic MiniMed 640G (Medtronic) over 12 hours was compared during mimicked real-life conditions (meals, exercise, hypo- and hyperglycaemia)...
February 16, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28202852/association-of-serum-uric-acid-levels-with-leg-ischemia-in-patients-with-peripheral-arterial-disease-after-treatment
#16
Yoko Sotoda, Shigeki Hirooka, Hiroyuki Orita, Ichiro Wakabayashi
AIM: We investigated the relationships of serum uric acid levels with the progression of atherosclerosis in patients with peripheral arterial disease (PAD) after treatment. METHODS: Subjects were male patients diagnosed with PAD. Atherosclerosis at the common carotid artery was evaluated based on its intima-media thickness (IMT). Leg arterial flow was evaluated by measuring ankle-brachial index (ABI) and exercise-induced decrease in ABI. RESULTS: Among various risk factors including age, blood pressure, adiposity, estimated glomerular filtration rate, and blood lipid, blood glucose, uric acid, fibrinogen and C-reactive protein levels, only uric acid levels showed significant correlations with ABI [Pearson's correlation coefficient, -0...
February 15, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28201825/heart-rate-and-oxygen-uptake-kinetics-in-type-2-diabetes-patients-a-pilot-study-on-the-influence-of-cardiovascular-medication-on-regulatory-processes
#17
Jessica Koschate, Uwe Drescher, Klaus Baum, Christian Brinkmann, Thorsten Schiffer, Joachim Latsch, Klara Brixius, Uwe Hoffmann
The aim of this pilot study was to investigate whether there are differences in heart rate and oxygen uptake kinetics in type 2 diabetes patients, considering their cardiovascular medication. It was hypothesized that cardiovascular medication would affect heart rate and oxygen uptake kinetics and that this could be detected using a standardized exercise test. 18 subjects were tested for maximal oxygen uptake. Kinetics were measured in a single test session with standardized, randomized moderate-intensity work rate changes...
February 15, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28198729/influence-of-land-or-water-exercise-in-pregnancy-on-outcomes-a-cross-sectional-study
#18
Ruben Barakat, Maria Perales, Yaiza Cordero, Mariano Bacchi, Michelle F Mottola
PURPOSE: To compare the cross-sectional results from three experimental studies conducted on land, in water, and mixed form (land + water) during pregnancy on maternal and newborn outcomes. METHODS: A cross-sectional design was used to analyze the results of three randomized clinical trials in healthy pregnant women from Madrid (Spain) and Buenos Aires (Argentina). Five hundred-sixty-eight pregnant women were recruited. For each of the studies, the number of women in the Exercise Group (EG) totalled 107 for Study I (land), 49 women for Study II (water), and 101 women for Study III (land + water)...
February 15, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28198702/epigenetic-clock-analysis-of-diet-exercise-education-and-lifestyle-factors
#19
Austin Quach, Morgan E Levine, Toshiko Tanaka, Ake T Lu, Brian H Chen, Luigi Ferrucci, Beate Ritz, Stefania Bandinelli, Marian L Neuhouser, Jeannette M Beasley, Linda Snetselaar, Robert B Wallace, Philip S Tsao, Devin Absher, Themistocles L Assimes, James D Stewart, Yun Li, Lifang Hou, Andrea A Baccarelli, Eric A Whitsel, Steve Horvath
Behavioral and lifestyle factors have been shown to relate to a number of health-related outcomes, yet there is a need for studies that examine their relationship to molecular aging rates. Toward this end, we use recent epigenetic biomarkers of age that have previously been shown to predict all-cause mortality, chronic conditions, and age-related functional decline. We analyze cross-sectional data from 4,173 postmenopausal female participants from the Women's Health Initiative, as well as 402 male and female participants from the Italian cohort study, Invecchiare nel Chianti...
February 14, 2017: Aging
https://www.readbyqxmd.com/read/28193598/barriers-to-remote-health-interventions-for-type-2-diabetes-a-systematic-review-and-proposed-classification-scheme
#20
Michelle M Alvarado, Hye-Chung Kum, Karla Gonzalez Coronado, Margaret J Foster, Pearl Ortega, Mark A Lawley
BACKGROUND: Diabetes self-management involves adherence to healthy daily habits typically involving blood glucose monitoring, medication, exercise, and diet. To support self-management, some providers have begun testing remote interventions for monitoring and assisting patients between clinic visits. Although some studies have shown success, there are barriers to widespread adoption. OBJECTIVE: The objective of our study was to identify and classify barriers to adoption of remote health for management of type 2 diabetes...
February 13, 2017: Journal of Medical Internet Research
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