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abnormal pap smear

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https://www.readbyqxmd.com/read/27891448/can-feulgen-stain-be-a-reliable-biomarker-over-pap-stain-for-estimation-of-micronuclei-score
#1
Manish Kumar, Umesh Chandra Prasad, Betina Chandolia, S M Manjunath, Shiva Basu, Silvie Verma
INTRODUCTION: Malignant transformation of the Potentially Malignant Lesions (PML) in the oral cavity is associated with elevated mortality rate because of its aggressive and exceedingly invasive nature. Meticulous diagnosis and prompt therapy of PML may help prevent malignant conversion in oral lesions. Carcinogenic insult to oral cells results in chromosomal damage and formation of Micronuclei (Mn), before the development of clinical symptoms. AIM: To determine the genotoxic effect of smoking and chewing tobacco on target tissue using Mn assay and to evaluate the prevalence of other nuclear anomalies associated with it and to determine the reliability of feulgen stain for Mn assay over Papaincolau (PAP) stain...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27891400/prevalence-of-human-papilloma-virus-infection-in-young-primiparous-women-during-postpartum-period-study-from-a-tertiary-care-center-in-northern-india
#2
Alpana Garg, Vanita Suri, Raje Nijhawan, Neelam Aggarwal, Ritu Aggarwal, Charu Guleria, Mili Thakur
INTRODUCTION: Assessment of high-risk Human Papilloma Virus (HPV) prevalence is important for monitoring long-term decrease in cervical cancer after implementation of the prophylactic HPV vaccination. AIM: To determine the prevalence of high-risk HPV infection and cytological abnormalities in young primiparous women in the age group of 16-26years. MATERIALS AND METHODS: In this cross-sectional study, 214 primiparous women aged 16-26years were recruited from a public tertiary health care center postpartum clinic between June 2013 and May 2014...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27886713/automated-classification-of-pap-smear-images-to-detect-cervical-dysplasia
#3
Kangkana Bora, Manish Chowdhury, Lipi B Mahanta, Malay Kumar Kundu, Anup Kumar Das
BACKGROUND AND OBJECTIVES: The present study proposes an intelligent system for automatic categorization of Pap smear images to detect cervical dysplasia, which has been an open problem ongoing for last five decades. METHODS: The classification technique is based on shape, texture and color features. It classifies the cervical dysplasia into two-level (normal and abnormal) and three-level (Negative for Intraepithelial Lesion or Malignancy, Low-grade Squamous Intraepithelial Lesion and High-grade Squamous Intraepithelial Lesion) classes reflecting the established Bethesda system of classification used for diagnosis of cancerous or precancerous lesion of cervix...
January 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/27864938/harms-of-cervical-cancer-screening-in-the-united-states-and-the-netherlands
#4
Dik Habbema, Sheila Weinmann, Marc Arbyn, Aruna Kamineni, Andrew E Williams, Inge McM de Kok, Folkert van Kemenade, Terry S Field, Joost van Rosmalen, Martin Brown
We studied harms related to cervical cancer screening and management of screen-positive women in the United States (US) and the Netherlands. We utilised data from four US integrated health care systems (SEARCH), the US National Health Interview Survey, New Mexico state, the Netherlands national histopathology registry, and included studies on adverse health effects of cervical screening. We compared the number of Papanicolaou (Pap) smear tests, abnormal test results, punch biopsies, treatments, health problems (anxiety, pain, bleeding, and discharge), and preterm births associated with excisional treatments...
November 16, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27835758/association-of-cytologic-grade-of-anal-pap-smears-with-viral-loads-of-human-papillomavirus-types-16-18-and-52-detected-in-the-same-specimens-from-men-who-have-sex-with-men
#5
Utaiwan Utaipat, Sumalee Siriaunkgul, Taweewat Supindham, Pongpun Saokhieo, Butsayarat Chaidaeng, Antika Wongthanee, Jongkolnee Settakorn, Kornkanok Sukpan, Darin Ruanpeng, Natthapol Kosashunhanan, Nuntisa Chotirosniramit, Patcharaphan Sugandhavesa, Toshiyuki Miura, Suwat Chariyalertsak
BACKGROUND: Human papilloma virus (HPV) load has been linked to cellular abnormalities of the uterine cervix, and proposed as predictors of HPV persistence and progression of dysplasia to cervical cancer. However, the association of HPV viral load and anal dysplasia and cancer has not been as thoroughly investigated. OBJECTIVES: To examine the association of the viral loads of high-risk HPV types 16, 18, and 52, with the cytologic severity grading in anal-swab specimens of MSM with and without HIV-1 co-infection...
November 6, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27831951/use-of-via-pap-smear-or-hr-hpv-testing-in-women-living-with-hiv-aids-for-post-treatment-cervical-cancer-screening-same-tests-different-priorities
#6
Omenge Orang'o, Tao Liu, Astrid Christoffersen-Deb, Peter Itsura, John Oguda, Sierra Washington, David Chumba, Latha Pisharodi, Susan Cu-Uvin, Anne F Rositch
OBJECTIVES: Few studies have addressed optimal follow-up for HIV-infected women after cervical treatment. This study aimed to compare performance of three available tests to detect post-treatment cervical disease in HIV-infected women in Kenya. DESIGN: This is a prospective cohort study. METHODS: At least six months following cryotherapy, 517 HIV-infected women were evaluated concurrently with VIA, Pap smear, and HR-HPV testing. Women positive by any test (≥LSIL for Pap) were scheduled for colposcopy and biopsy...
November 7, 2016: AIDS
https://www.readbyqxmd.com/read/27831652/expression-of-e6-e7-hpv-dna-hpv-mrna-and-colposcopic-features-in-management-of-cin2-3-during-pregnancy
#7
A Frega, A Verrone, F Manzara, M Schimberni, A Catalano, G N Milazzo, R Marziani, G Cozza, P Bianchi, D French, F Sesti, D Caserta
OBJECTIVE: The incidence of abnormal cervical cytology in pregnancy is similar to that reported for non-pregnant women. Furthermore, 1% of pregnant women annually screened for cervical cancer will be diagnosed with cervical intraepithelial neoplasia (CIN) of various degrees. For this reason, Pap smear should be performed in the first trimester of pregnancy. The persistence of HR-HPV infection is related to the development of CIN. However, the relationship between CIN and HR-HPV infection during pregnancy and postpartum can hardly be found...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27821987/a-study-of-pap-smear-in-hiv-positive-females
#8
Apeksha Madan, Sunita Patil, Leena Nakate
BACKGROUND: HIV-positive females are more likely to have abnormal Pap smears than HIV-negative women. These abnormal Pap smears are usually associated with low CD4 cell counts and human papilloma virus infection. MATERIALS AND METHODS: This was a prospective hospital-based study from April 2013 till March 2014. A total of 250 (both symptomatic and asymptomatic) HIV-positive females were examined in Gynaecology OPD at R.C.S.M. G.M.C and C.P.R. Hospital, Kolhapur, and their cervical smears were taken...
December 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27797219/clinical-factors-associated-with-specimen-adequacy-for-conventional-cervical-cytology-in-thammasat-university-hospital-thailand
#9
Akegapot Anantaworapot, Sakol Manusook, Chamnan Tanprasertkul, Supapen Lertvutivivat, Athita Chanthasenanont, Kornkarn Bhamarapravatana, Komsun Suwannarurk
PURPOSE: To study clinical factors related to adequacy of transformation zone (TZ) components in cervical smears. MATERIALS AND METHODS: Medical and Papanicolaou (Pap) smear reports from Thammasat University Hospital, Thailand during January to December 2015 were collected. Demographic data was reviewed by attending physicians and impact of clinical factors onTZ adequacy was primary outcome. A total of 3,251 smears were reviewed. Finally, 2,098 smears met The inclusion criteria and enrolled into this study...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27703293/diagnostic-approach-to-patients-with-atypical-squamous-cells-of-undetermined-significance-cytologic-findings-on-cervix
#10
Mahira Jahic, Elmir Jahic
BACKGROUND: Atypical squamous cells of undetermined significance (ASCUS) is a term that refers to inflammatory, reactive and reparative processes which are atypical and of higher level and insufficient to be classified as cervical intraepithelial lesions (CIN). AIMS: Examine of frequency of HPV infection in ASCUS lesions and regression, stagnation and progression during six-month period. SUBJECTS AND METHODS: Prospective study was conducted over a period of 3 years...
July 27, 2016: Medical Archives
https://www.readbyqxmd.com/read/27647799/excellent-analytical-and-clinical-performance-of-a-dry-self-sampling-device-for-human-papillomavirus-detection-in-an-urban-chinese-referral-population
#11
KeWei Chen, YiQin Ouyang, Peter Hillemanns, Matthias Jentschke
AIM: To evaluate the analytical and clinical effectiveness of cervicovaginal self-sampling with a dry sampling device (Evalyn Brush) for high-risk human papillomavirus (hr-HPV) testing and detection of cervical disease. METHODS: The study population consisted of 101 patients from a large gynecological outpatient clinic in Shanghai referred for abnormal cervical screening results and 101 women without cervical lesions. Self-samples obtained in the clinic and physician-collected cervical specimens (reference) were stored at -20 °C for 16-18 weeks and then transferred to 20 ml of ThinPrep medium and tested for hr-HPV using a multiplex real time polymerase chain reaction assay...
September 20, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27644678/prevalence-and-risk-assessment-of-cervical-cancer-screening-by-papanicolaou-smear-and-visual-inspection-with-acetic-acid-for-pregnant-women-at-a-thai-provincial-hospital
#12
Jiraporn Lertcharernrit, Panya Sananpanichkul, Wineeya Suknikhom, Kornkarn Bhamarapravatana, Komsun Suwannarurk, Yosapon Leaungsomnapa
BACKGROUND: Cervical cancer is the second most common in Thailand, but the mortality rate may be rising yearly. It is a cancer that can be prevented by early screening for precancerous lesions, several methods being available. OBJECTIVE: To identify the prevalence of abnormal Papanicolaou (Pap) smears and lesions with visual inspection with acetic acid (VIA) in pregnant women and assess risk factors for this group. MATERIALS AND METHODS: This prospective study was performed at Prapokklao Hospital, Thailand during April-July 2016...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27641071/cervical-cytological-abnormalities-and-human-papilloma-virus-infection-in-women-infected-with-hiv-in-southern-india
#13
Suchitra Thunga, Anusmitha Andrews, John Ramapuram, Kapaettu Satyamoorthy, Hema Kini, B Unnikrishnan, Prabha Adhikari, Prakhar Singh, Shama Prasada Kabekkodu, Samatha Bhat, Anagha Kadam, Avinash K Shetty
AIM: The aim of this study was to examine the association between CD4 count, human papilloma virus (HPV) infection, and the risk of cervical intraepithelial neoplasia among HIV-infected women. METHODS: A cross-sectional study was conducted among 104 HIV-infected women attending an antiretroviral therapy clinic. They underwent Pap smear and cervical HPV DNA testing. RESULTS: The overall prevalence of HPV infection was 57.7%. HPV 16 was the commonest genotype found (38...
September 19, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27630912/comparison-of-vaginal-versus-oral-estradiol-administration-in-improving-the-visualization-of-transformation-zone-tz-during-colposcopy
#14
Seema Beniwal, Binni Makkar, Swaraj Batra, Gauri Gandhi, Deepti Goswami, Vijay Zutshi
INTRODUCTION: Colposcopy is an important diagnostic tool in the evaluation of patients with abnormal pap smears. However, in 10-20% transformation zone (TZ)/squamo-columnar junction is not completely visualized and these patients are deemed to have an incomplete colposcopy examination. Such patients usually require conization, a procedure associated with significant morbidity. Various agents like misoprostol, estrogens and laminaria tents have been used in the past to overcome the non-visualization of TZ...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27582634/molecular-detection-of-human-papillomavirus-from-abnormal-cervical-cytology-of-women-attending-a-tertiary-health-facility-in-ido-ekiti-southwest-nigeria
#15
REVIEW
O M Kolawole, K T Olatunji, K A Durowade
BACKGROUND: Human papillomavirus (HPV) has been implicated as one of the principal causes of cervical cancer, which is the second highest cause of cancer deaths among Nigerian women. OBJECTIVE: This study was aimed at determining the presence of HPV DNA in abnormal cervical cytology of a group of women who were screened using Papanicolaou staining technique. METHODOLOGY: A total of 200 women attending the Obstetrics and Gynaecology clinic of the Federal Teaching Hospital, Ido-Ekiti, were screened by means of conventional Pap smear screening, while positive samples underwent molecular analyses by means of DNA isolation techniques and polymerase chain reaction (PCR)...
2016: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/27514955/prevalence-of-high-risk-human-papilloma-virus-types-and-cervical-smear-abnormalities-in-female-sex-workers-in-chandigarh-india
#16
M P Singh, M Kaur, N Gupta, A Kumar, K Goyal, A Sharma, M Majumdar, M Gupta, R K Ratho
PURPOSE: Cervical cancer is the most common cancer among women in developing nations. Nearly 90% of the cases have been linked to the presence of high-risk human papillomavirus (hrHPV) types 16 and 18. The risk of cervical cancer may be high in female sex workers (FSWs) due to multiple sexual partners. This study aimed to determine the prevalence of cytological abnormalities and hrHPV types 16 and 18 in FSWs in Chandigarh, North India using the liquid-based cytology (LBC) approach. MATERIALS AND METHODS: The cervical brush samples were collected from 120 FSW and 98 age-matched healthy controls (HCs)...
July 2016: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27504358/association-of-intrauterine-device-iud-and-cervical-neoplasia-a-study-in-a-poor-nigerian-population
#17
Leonard Ogbonna Ajah, Chibuike Ogwuegbu Chigbu, Benjamin Chukwuma Ozumba, Theophilus Chimezie Oguanuo, Paul Olisaemeka Ezeonu
INTRODUCTION: Intrauterine Device (IUD) is a contraceptive method used by women of reproductive age group. However, there are conflicting reports on the association between IUD and cervical neoplasia. These controversies may further hamper the poor uptake of modern contraception in Nigeria. AIM: This study was therefore aimed at evaluating the association between IUD and cervical neoplasia. MATERIALS AND METHODS: This was a case control study in which Pap smear results of 156 participants on IUD were compared with those of 156 non-users of modern contraception...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27478909/predictive-value-of-p16-ki-67-immunocytochemistry-for-triage-of-women-with-abnormal-papanicolaou-test-in-cervical-cancer-screening-a-systematic-review-and-meta-analysis
#18
Cheng-Chieh Chen, Lee-Wen Huang, Chyi-Huey Bai, Chin-Cheng Lee
BACKGROUND: The Papanicolaou (Pap) test is one screening strategy used to prevent cervical cancer in developed countries. The p16/Ki-67 immunocytochemistry is a triage test performed on Pap smears in women with atypical squamous cells of undetermined significance (ASCUS) or low grade squamous intraepithelial lesion. OBJECTIVE: Our objective was to review studies investigating the diagnostic performance of p16/Ki-67 dual stain for triage of women with abnormal Pap tests...
July 2016: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/27449030/challenges-to-pap-smear-follow-up-among-women-in-the-criminal-justice-system
#19
Patricia J Kelly, Jennifer Hunter, Elizabeth Brett Daily, Megha Ramaswamy
Women involved in the United States criminal justice system face a variety of challenges in maintaining their health. Histories of sexual abuse, early initiation of sex, and substance abuse are reflected in more negative reproductive health outcomes, including cervical cancer, than those found among non-incarcerated women. Little is known about how to close this health gap. The present study assessed what incarcerated women perceived to be facilitators and inhibitors of obtaining recommended follow-up for abnormal Pap tests...
July 22, 2016: Journal of Community Health
https://www.readbyqxmd.com/read/27447054/low-uptake-of-human-papillomavirus-vaccine-among-postpartum-women-2006-2012
#20
Kimberly A Kilfoyle, Lisa Rahangdale, Stacie B Dusetzina
BACKGROUND: Young adult women find it acceptable to be offered the human papillomavirus (HPV) vaccine postpartum. Little is known about the practice of administering the HPV vaccine during the postpartum period. MATERIALS AND METHODS: The Truven Health Analytics MarketScan Commercial Claims and Encounters database was used to develop a cohort of privately insured 18 to 26-year-old women with uncomplicated live-born pregnancies. Eligibility required no previous doses of HPV vaccine before delivery and continuous insurance enrollment from June 2006 through 1 year postpartum...
July 22, 2016: Journal of Women's Health
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