Lara Paracchini, Laura Mannarino, Chiara Romualdi, Riccardo Zadro, Luca Beltrame, Ilaria Fuso Nerini, Paolo Zola, Maria E Laudani, Eva Pagano, Livia Giordano, Robert Fruscio, Fabio Landoni, Silvia Franceschi, Maria L Dalessandro, Vincenzo Canzonieri, Luca Bocciolone, Domenica Lorusso, Cristina Bosetti, Francesco Raspagliesi, Isabella M G Garassino, Maurizio D'Incalci, Sergio Marchini
Late diagnosis and the lack of screening methods for early detection define high-grade serous ovarian cancer (HGSOC) as the gynecological malignancy with the highest mortality rate. In the work presented here, we investigated a retrospective and multicentric cohort of 250 archival Papanicolaou (Pap) test smears collected during routine gynecological screening. Samples were taken at different time points (from 1 month to 13.5 years before diagnosis) from 113 presymptomatic women who were subsequently diagnosed with HGSOC (pre-HGSOC) and from 77 healthy women...
December 6, 2023: Science Translational Medicine