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Chenju Yi, Annette Koulakoff, Christian Giaume
BACKGROUND: In Alzheimer's disease (AD), modification of astrocytic properties is a well-known and documented fact, but their involvement in pathophysiology has only been examined in recent years. One distinct hallmark of AD is reactive gliosis which are represented in microglial and astrocytic phenotype changes. This reactive gliosis has been associated with changes in the expression and function of connexins. Connexins are proteins that can form gap junction channels and hemichannels, and in a disease context, have shown increased expression in astrocytes that contact amyloid plaques in vivo...
2017: Current Pharmaceutical Design
R A Samy, D George, A K Sen
We report bio-inspired (from a hummingbird's tongue) liquid transport via elastocapillary interaction of a thin membrane with a liquid meniscus. A soft wedge-thin rectangular membrane forming a wedge with a rigid substrate and a flat thin rectangular membrane undergo large deformation while interacting with liquid menisci. The membrane deformation leads to the formation of confinement which in turn results in elastocapillary flow along the membrane length. A simple theoretical model based on the Euler Bernoulli law is used to predict the membrane deformation profiles, which compare well with that obtained from experiments...
October 4, 2017: Soft Matter
Lauren K Hoffman, James Q Del Rosso, Leon H Kircik
<p>INTRODUCTION: Truncal acne is often associated with facial acne, but there are fewer options for an effective topical treatment on the trunk. Given the advent of foam formulations with enhanced percutaneous absorption and convenient application due to easy spreadability on skin, the previously held idea that effective treatment of truncal acne requires oral treatment is challenged. Azelaic acid cream has been previously approved for acne vulgaris, thus azelaic acid foam may be a viable treatment option for truncal acne...
June 1, 2017: Journal of Drugs in Dermatology: JDD
Wenyan Tian, Jiaqing Shen, Weichang Chen
Midkine (MK) is reported to be associated with the clinical stages and distant metastases in gastric cancer, and to positively regulate the proliferation of human gastric cancer cells. However, the possible mechanisms of MK in the development of gastric cancer are still not fully clarified. In this study, the therapeutic effect of MK inhibition in gastric cancer in vivo and in vitro was investigated, by knock-down of MK expression with a small interfering RNA (siRNA). MK was expressed in gastric carcinoma tissues and cancer cells...
August 2017: Oncology Reports
Mingyue Zhu, Junli Guo, Hua Xia, Wei Li, Yan Lu, Xu Dong, Yi Chen, Xieju Xie, Shigan Fu, Mengsen Li
CXCR4, stromal cell-derived factor-1α(SDF 1α) receptor, stimulates growth and metastasis of hepatocellular carcinoma (HCC). Alpha-fetoprotein(AFP) governs the expression of some metastasis-related genes. Here we report that AFP and CXCR4 levels correlated in HCC tissues. AFP-expressing vectors induced CXCR4. In agreement, AFP depletion by siRNA decreased CXCR4. AFP co-localized and interacted with PTEN, thus inducing CXCR4 by activating AKT(Ser473) phosphorylation. In turn, phospho-mTOR(Ser2448) entered the nucleus and bound the CXCR4 gene promoter...
2015: Oncoscience
M A Fernandez, S Karthikeyan, M Wyse, P Foguet
INTRODUCTION: Postoperative urinary retention requiring urethral catheterisation increases the risk of joint sepsis following arthroplasty. Spinal anaesthesia with opiate administration is used widely in lower limb arthroplasty. We sought to establish whether the choice of opiate agent had any effect on the incidence of postoperative retention and therefore the risk of joint sepsis. METHODS: A total of 445 consecutive patients who underwent primary elective lower limb arthroplasty were reviewed retrospectively...
September 2014: Annals of the Royal College of Surgeons of England
R Hlubek, P Walder, J Káňa, D Salounová
PURPOSE OF THE STUDY: Surgical incision closure, as well as total joint replacement itself, plays a key role in the overall outcome of an arthroplasty procedure. Uncomplicated wound healing is the essential condition of successful rehabilitation and the patient's return to normal activities. Although there are many innovative suturing techniques which offer advantages, their safety is still being discussed. The aim of this prospective non-blind randomised study was to evaluate wound healing and complications in relation to skin incision closure with either conventional suture or metal staples...
2014: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
Michelle K Blocklin, Ann C Crouter, Susan M McHale
Using data from a daily diary study of hourly hotel employees in the U.S. and their children, this study examined links between youth supervision arrangements and maternal worry while at work, examining both differences between individuals and day-to-day variation within individuals. Multilevel model analyses revealed both between- and within-person effects linking youth supervision to maternal worry. Mothers' partner status functioned as moderator, and maternal knowledge also emerged as a protective factor when youth were in self-care, highlighting a potential target for future work-family interventions, particularly those for hourly employees with limited access to family-friendly workplace policies...
2012: Community, Work & Family
Steven Lane, Devinder Gill, Nigel A J McMillan, Nicholas Saunders, Rachel Murphy, Terrence Spurr, Colm Keane, Helen Mar Fan, Peter Mollee
Abstract Elderly patients with acute myeloid leukemia (AML) have a poor prognosis. The authors examined the in vitro and clinical activity of the histone deacetylase inhibitor valproic acid (VA) combined with cytosine arabinoside (AraC) in elderly patients with AML unsuited to intensive therapy. For the in vitro studies, primary AML cells from 11 patients were treated with AraC and VA and analyzed for apoptosis, cytostatic effects, differentiation and acetyl histone H3 induction. VA (alone and with AraC) enhanced apoptosis and induced acetyl histone H3...
June 2012: Leukemia & Lymphoma
Chris Ellis, Greg Gamble, Andrew Hamer, Michael Williams, Philip Matsis, John Elliott, Gerard Devlin, Mark Richards, Harvey White
AIMS: To audit all patients admitted to a New Zealand (NZ) Hospital with an acute coronary syndrome (ACS) over a 14-day period, to assess their number, presentation type and patient management during the hospital admission and at discharge. To compare patient management in 2007 with the 1st NZ Cardiac Society ACS Audit from 2002. METHODS: We updated the established NZ ACS Audit group of 36 hospitals to 39 hospitals now admitting ACS patients across New Zealand. A comprehensive data form was used to record individual patient information for all patients admitted between 00...
July 30, 2010: New Zealand Medical Journal
S Chibbaro, E Costa, D I Dimitrov, F Diotallevi, A Milchev, D Palmieri, G Pontrelli, S Succi
We study the impact of wall corrugations in microchannels on the process of capillary filling by means of three broadly used methods: computational fluid dynamics (CFD), lattice Boltzmann equations (LBE), and molecular dynamics (MD). The numerical results of these approaches are compared and tested against the Concus-Finn (CF) criterion, which predicts pinning of the contact line at rectangular ridges perpendicular to flow for contact angles of theta > 45 degrees . Whereas for theta = 30, 40 (no flow), and 60 degrees (flow) all methods are found to produce data consistent with the CF criterion, at theta = 50 degrees the numerical experiments provide different results...
November 3, 2009: Langmuir: the ACS Journal of Surfaces and Colloids
Dorota Pach, Alicja Hubalewska-Dydejczyk, Magdalena Szurkowska, Aleksandra Kamenczak, Dorota Targosz, Tomasz Gawlikowski, Bohdan Huszno, Bogusław Głowa
UNLABELLED: The depressant actions of ethanol in the brain is known. SPECT is non invasive method to measure the regional cerebral blood flow (rCBF) and to evaluate indirectly the brain metabolism. The aim of the study is to evaluate morphologic and functional status of CNS using 99mTc-ECD SPECT in chronic alcoholics. MATERIAL AND METHODS: Examined group consisted of 18 male alcoholic patients aged from 28 to 52 years (x = 42.1 +/- 5.4) treated at the Ward of Toxicology and Environmental Diseaes (Detoxification Unit)...
2007: Przegla̧d Lekarski
Myra Kitron-Belinkov, Abraham Marmur, Thomas Trabold, Gayatri Vyas Dadheech
Spontaneous capillary flow (SCF) of a drop in a groove with an ideally sharp corner is possible when the Concus-Fin (CF) condition is fulfilled. However, since ideally sharp corners do not exist in reality, it is important to understand the effect of finite corner curvature on SCF. This effect is analytically studied for long drops in a V-shaped groove with a curved corner, leading to a generalization of the CF condition for such drops. The generalized condition implies that SCF depends on the geometry of the corner as well as on the dimensionless length of the drop, in addition to its dependence on the opening angle and contact angle that is covered by the CF condition...
July 31, 2007: Langmuir: the ACS Journal of Surfaces and Colloids
P Concus, R Finn
Estimates above and below are obtained for the height of the equilibrium-free surface of a liquid when the liquid partially fills a cylindrical container whose cross section contains a corner with interior angle 2alpha. The surface is characterized by the condition that its mean curvature be proportional to its height above a reference plane (or, in the case of zero gravity, that the mean curvature be constant), and by the requirement that it meet the container wall with prescribed contact angle gamma. It turns out that the qualitative behavior of such a surface near the vertex changes markedly, according as alpha + gamma < (1/2)pi, or alpha + gamma >/= (1/2)pi...
June 1969: Proceedings of the National Academy of Sciences of the United States of America
Samuel Ryu, Mumtaz Khan, Fang-Fang Yin, Adrianne Concus, Munther Ajlouni, Michael S Benninger, Jae Ho Kim
OBJECTIVES: Radiosurgery precisely delivers a single high dose or a few fractionated doses of radiation to a localized tumor via the stereotactic approach. Some head and neck sites are suitable for radiosurgery since there is minimal or no organ motion. The clinical studies were carried out to determine the accuracy of stereotactic radiosurgery and to demonstrate the effectiveness of radiosurgery in head and neck cancers. MATERIALS AND METHODS: Thirteen patients were treated with either single-dose or fractionated radiosurgery to the tumor...
June 2004: Otolaryngology—Head and Neck Surgery
T L Chen, Y J Zhou, Z F Wu
OBJECTIVE: Study the effects of Gu Chi paste on PGE(2) in gingiva and alveolar bone and its mechanism to treating periodontitis. METHODS: Periodontitis were formed with silk thread suture and high sugar diet,fed guinea pigs on Gu Chi paste and indomethacin.The prostaglandin E(2)(PGE(2)) in gingiva and alveolar bone were measured with radioimmunoassay (RIA). RESULTS: The Gingival Index(GI) and Pocket Deep(PD) of group Periodontitis (PE) were bigger than group Normal(N),the alveolar bone absorbed more severe,the PGE(2) level in gingiva and alveolar bone in PE was higherthan that in N...
December 1998: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
No abstract text is available yet for this article.
March 1955: Voprosy Neĭrokhirurgii
No abstract text is available yet for this article.
November 1960: Archives of Otolaryngology
No abstract text is available yet for this article.
May 23, 1953: Wiener Medizinische Wochenschrift
Maria J Worsham, Gerard Pals, Jan P Schouten, Rosalind M L Van Spaendonk, Adriane Concus, Thomas E Carey, Michael S Benninger
OBJECTIVE: To identify altered gene targets that characterize disease progression in squamous cell carcinoma (SCC) of the head and neck (HNSCC). Genetic alterations in HNSCC cell lines reflect the tumor in vivo and can serve as valuable tools to study the development and progression of HNSCC. Identification of key molecular events may be useful for more accurate distinction of prognostic groups for selection and targeting of therapy. DESIGN: Individual gene loci were analyzed for genetic alterations using a novel genomewide strategy...
July 2003: Archives of Otolaryngology—Head & Neck Surgery
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