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Radial glial cell

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https://www.readbyqxmd.com/read/29792854/bergmann-glial-sonic-hedgehog-signaling-activity-is-required-for-proper-cerebellar-cortical-expansion-and-architecture
#1
Frances Y Cheng, Jonathan T Fleming, Chin Chiang
Neuronal-glial relationships play a critical role in the maintenance of central nervous system architecture and neuronal specification. A deeper understanding of these relationships can elucidate cellular cross-talk capable of sustaining proper development of neural tissues. In the cerebellum, cerebellar granule neuron precursors (CGNPs) proliferate in response to Purkinje neuron-derived Sonic hedgehog (Shh) before ultimately exiting the cell cycle and migrating radially along Bergmann glial fibers. However, the function of Bergmann glia in CGNP proliferation remains not well defined...
May 21, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29779941/the-epigenetic-state-of-prdm16-regulated-enhancers-in-radial-glia-controls-cortical-neuron-position
#2
José-Manuel Baizabal, Meeta Mistry, Miguel Turrero García, Nicolás Gómez, Olubusola Olukoya, Diana Tran, Matthew B Johnson, Christopher A Walsh, Corey C Harwell
The epigenetic landscape is dynamically remodeled during neurogenesis. However, it is not understood how chromatin modifications in neural stem cells instruct the formation of complex structures in the brain. We report that the histone methyltransferase PRDM16 is required in radial glia to regulate lineage-autonomous and stage-specific gene expression programs that control number and position of upper layer cortical projection neurons. PRDM16 regulates the epigenetic state of transcriptional enhancers to activate genes involved in intermediate progenitor cell production and repress genes involved in cell migration...
May 15, 2018: Neuron
https://www.readbyqxmd.com/read/29764857/lineage-guided-notch-dependent-gliogenesis-by-drosophila-multi-potent-progenitors
#3
Qingzhong Ren, Takeshi Awasaki, Yu-Chun Wang, Yu-Fen Huang, Tzumin Lee
Macroglial cells in the central nervous system exhibit regional specialization and carry out region-specific functions. Diverse glial cells arise from specific progenitors in specific spatiotemporal patterns. This raises an interesting possibility that there exist glial precursors with distinct developmental fates, which govern region-specific gliogenesis. Here we mapped the glial progeny produced by the Drosophila type II neuroblasts, which, like vertebrate radial glia cells, yield both neurons and glia via intermediate neural progenitors (INPs)...
May 15, 2018: Development
https://www.readbyqxmd.com/read/29751817/tcf7l2-is-essential-for-neurogenesis-in-the-developing-mouse-neocortex
#4
Olga Chodelkova, Jan Masek, Vladimir Korinek, Zbynek Kozmik, Ondrej Machon
Generation of neurons in the embryonic neocortex is a balanced process of proliferation and differentiation of neuronal progenitor cells. Canonical Wnt signalling is crucial for expansion of radial glial cells in the ventricular zone and for differentiation of intermediate progenitors in the subventricular zone. We detected abundant expression of two transcrtiption factors mediating canonical Wnt signalling, Tcf7L1 and Tcf7L2, in the ventricular zone of the embryonic neocortex. Conditional knock-out analysis showed that Tcf7L2, but not Tcf7L1, is the principal Wnt mediator important for maintenance of progenitor cell identity in the ventricular zone...
May 11, 2018: Neural Development
https://www.readbyqxmd.com/read/29748916/zbtb20-regulates-developmental-neurogenesis-in-the-olfactory-bulb-and-gliogenesis-after-adult-brain-injury
#5
Thorsten R Doeppner, Josephine Herz, Mathias Bähr, Anton B Tonchev, Anastassia Stoykova
The transcription factor (TF) Zbtb20 is important for the hippocampal specification and the regulation of neurogenesis of neocortical projection neurons. Herein, we show a critical involvement of the TF Zbtb20 in the neurogenesis of both projection neurons and interneurons of the olfactory bulb during embryonic stages. Our data indicate that the lack of Zbtb20 significantly diminishes the generation of a set of early-born Tbr2+ neurons during embryogenesis. Furthermore, we provide evidence that Zbtb20 regulates the transition between neurogenesis to gliogenesis in cortical radial glial progenitor cells at the perinatal (E18...
May 11, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29722804/hippocampal-radial-glial-subtypes-and-their-neurogenic-potential-in-human-fetuses-and-healthy-and-alzheimer-s-disease-adults
#6
Sara Cipriani, Isidre Ferrer, Eleonora Aronica, Gabor G Kovacs, Catherine Verney, Jeannette Nardelli, Suonavy Khung, Anne-Lise Delezoide, Ivan Milenkovic, Sowmyalakshmi Rasika, Philippe Manivet, Jean-Louis Benifla, Nicolas Deriot, Pierre Gressens, Homa Adle-Biassette
Neuropathological conditions might affect adult granulogenesis in the adult human dentate gyrus. However, radial glial cells (RGCs) have not been well characterized during human development and aging. We have previously described progenitor and neuronal layer establishment in the hippocampal pyramidal layer and dentate gyrus from embryonic life until mid-gestation. Here, we describe RGC subtypes in the hippocampus from 13 gestational weeks (GW) to mid-gestation and characterize their evolution and the dynamics of neurogenesis from mid-gestation to adulthood in normal and Alzheimer's disease (AD) subjects...
May 2, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29680832/differential-fatty-acid-binding-protein-expression-in-persistent-radial-glia-in-the-human-and-sheep-subventricular-zone
#7
Birger Victor Dieriks, Justin M Dean, Eleonora Aronica, Henry J Waldvogel, Richard L M Faull, Maurice A Curtis
Fatty acid-binding proteins (FABPs) are a family of transport proteins that facilitate intracellular transport of fatty acids. Despite abundant expression in the brain, the role that FABPs play in the process of cell proliferation and migration in the subventricular zone (SVZ) remains unclear. Our results provide a detailed characterisation of FABP3, 5, and 7 expression in adult and fetal human and sheep SVZ. High FABP5 expression was specifically observed in the adult human SVZ and co-labelled with polysialylated neural cell adhesion molecule (PSA-NCAM), glial fibrillary acidic protein (GFAP), GFAPδ, and proliferating cell nuclear antigen (PCNA), indicating a role for FABP5 throughout the full maturation process of astrocytes and neuroblasts...
April 20, 2018: Developmental Neuroscience
https://www.readbyqxmd.com/read/29663194/centrosome-inheritance-does-not-regulate-cell-fate-in-granule-neuron-progenitors-of-the-developing-cerebellum
#8
Anindo Chatterjee, Kaviya Chinnappa, Narendrakumar Ramanan, Shyamala Mani
An inherent asymmetry exists between the two centrosomes of a dividing cell. One centrosome is structurally more mature (mother centrosome) than the other (daughter centrosome). Post division, one daughter cell inherits the mother centrosome while the other daughter cell inherits the daughter centrosome. Remarkably, the kind of centrosome inherited is associated with cell fate in several developmental contexts such as in radial glial progenitors in the developing mouse cortex, Drosophila neuroblast divisions and in Drosophila male germline stem cells...
April 16, 2018: Cerebellum
https://www.readbyqxmd.com/read/29655871/cloning-partial-sequencing-and-expression-analysis-of-the-neural-form-of-p450-aromatase-cyp19a1b-in-the-south-america-catfish-rhamdia-quelen
#9
Helena C Silva de Assis, Laia Navarro-Martín, Letícia S P Fernandes, Cibele C Cardoso, Daniela Parada Pavoni, Vance L Trudeau
Brain aromatase is a key enzyme exclusively expressed in fish radial glial cells that convert androgens into estrogens, thus controlling neuroendocrine functions and neurogenesis. As an important step in characterizing the neuroendocrine systems of Rhamdia quelen (jundiá), a partial cDNA sequence (1045 bp) of brain aromatase (cyp19a1b) was cloned and sequenced. At the nucleotide level the cDNA sequence was found to be 88% identical to cyp19a1b of two species of catfish, Ictalurus punctatus and Silurus meridionalis...
April 12, 2018: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29655639/glia-maturation-factor-beta-is-required-for-reactive-gliosis-after-traumatic-brain-injury-in-zebrafish
#10
Guo Yin, Mingjun Du, Rong Li, Ke Li, Xiaomin Huang, Dongbei Duan, Xiaolan Ai, Fang Yao, Lanlan Zhang, Ziyou Hu, Bingyi Wu
Gliosis is a hallmark of neural pathology that occurs after most forms of central nervous system (CNS) injuries including traumatic brain injury (TBI). Identification of genes that control gliosis may provide novel treatment targets for patients with diverse CNS injuries. Glia maturation factor beta (GMFB) is crucial in brain development and stress response. In the present study, GMFB was found to be widely expressed in adult zebrafish telencephalon. A gmfb mutant zebrafish was created using CRISPR/cas9. In the uninjured zebrafish telencephalon, glial fibrillary acidic protein (GFAP) fibers in gmfb mutants were disorganized and shorter than wild type zebrafish...
April 12, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29643508/aspm-knockout-ferret-reveals-an-evolutionary-mechanism-governing-cerebral-cortical-size
#11
Matthew B Johnson, Xingshen Sun, Andrew Kodani, Rebeca Borges-Monroy, Kelly M Girskis, Steven C Ryu, Peter P Wang, Komal Patel, Dilenny M Gonzalez, Yu Mi Woo, Ziying Yan, Bo Liang, Richard S Smith, Manavi Chatterjee, Daniel Coman, Xenophon Papademetris, Lawrence H Staib, Fahmeed Hyder, Joseph B Mandeville, P Ellen Grant, Kiho Im, Hojoong Kwak, John F Engelhardt, Christopher A Walsh, Byoung-Il Bae
The human cerebral cortex is distinguished by its large size and abundant gyrification, or folding. However, the evolutionary mechanisms that drive cortical size and structure are unknown. Although genes that are essential for cortical developmental expansion have been identified from the genetics of human primary microcephaly (a disorder associated with reduced brain size and intellectual disability) 1 , studies of these genes in mice, which have a smooth cortex that is one thousand times smaller than the cortex of humans, have provided limited insight...
April 11, 2018: Nature
https://www.readbyqxmd.com/read/29614754/mixture-concentration-response-modeling-reveals-antagonistic-effects-of-estradiol-and-genistein-in-combination-on-brain-aromatase-gene-cyp19a1b-in-zebrafish
#12
Nathalie Hinfray, Cleo Tebby, Benjamin Piccini, Gaelle Bourgine, Sélim Aït-Aïssa, Jean-Marc Porcher, Farzad Pakdel, François Brion
Comprehension of compound interactions in mixtures is of increasing interest to scientists, especially from a perspective of mixture risk assessment. However, most of conducted studies have been dedicated to the effects on gonads, while only few of them were. interested in the effects on the central nervous system which is a known target for estrogenic compounds. In the present study, the effects of estradiol (E2), a natural estrogen, and genistein (GEN), a phyto-estrogen, on the brain ER-regulated cyp19a1b gene in radial glial cells were investigated alone and in mixtures...
April 1, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29603210/cellular-composition-and-organization-of-the-spinal-cord-central-canal-during-metamorphosis-of-the-frog-xenopus-laevis
#13
Gabriela Edwards-Faret, Arantxa Cebrián-Silla, Emilio E Méndez-Olivos, Karina González-Pinto, José Manuel García-Verdugo, Juan Larraín
Studying the cellular composition and morphological changes of cells lining the central canal during Xenopus laevis metamorphosis could contribute to understand postnatal development and spinal cord regeneration. Here we report the analysis of central canal cells at different stages during metamorphosis using immunofluorescence for protein markers expression, transmission and scanning electron microscopy and cell proliferation assays. The central canal was regionalized according to expression of glial markers, ultrastructure and proliferation in dorsal, lateral and ventral domains with differences between larvae and froglets...
March 30, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29570795/cortical-progenitor-biology-key-features-mediating-proliferation-versus-differentiation
#14
REVIEW
Ana Uzquiano, Ivan Gladwyn-Ng, Laurent Nguyen, Orly Reiner, Magdalena Götz, Fumio Matsuzaki, Fiona Francis
The cerebral cortex is a highly organized structure whose development depends on diverse progenitor cell types, namely apical radial glia, intermediate progenitors and basal radial glia cells, which are responsible for the production of the correct neuronal output. In recent years, these progenitor cell types have been deeply studied, particularly basal radial glial and their role in cortical expansion and gyrification. We review here a broad series of factors to regulate progenitor behavior and daughter cell fate...
March 23, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29568500/radial-glial-cells-in-the-adult-dentate-gyrus-what-are-they-and-where-do-they-come-from
#15
REVIEW
Daniel A Berg, Allison M Bond, Guo-Li Ming, Hongjun Song
Adult neurogenesis occurs in the dentate gyrus in the mammalian hippocampus. These new neurons arise from neural precursor cells named radial glia-like cells, which are situated in the subgranular zone of the dentate gyrus. Here, we review the emerging topic of precursor heterogeneity in the adult subgranular zone. We also discuss how this heterogeneity may be established during development and focus on the embryonic origin of the dentate gyrus and radial glia-like stem cells. Finally, we discuss recently developed single-cell techniques, which we believe will be critical to comprehensively investigate adult neural stem cell origin and heterogeneity...
2018: F1000Research
https://www.readbyqxmd.com/read/29568390/characterization-of-brain-tumor-initiating-cells-isolated-from-an-animal-model-of-cns-primitive-neuroectodermal-tumors
#16
Sergey Malchenko, Simone T Sredni, Jerusha Boyineni, Yingtao Bi, Naira V Margaryan, Maheedhara R Guda, Yulia Kostenko, Tadanori Tomita, Ramana V Davuluri, Kiran Velpula, Mary J C Hendrix, Marcelo B Soares
CNS Primitive Neuroectodermal tumors (CNS-PNETs) are members of the embryonal family of malignant childhood brain tumors, which remain refractory to current therapeutic treatments. Current paradigm of brain tumorigenesis implicates brain tumor-initiating cells (BTIC) in the onset of tumorigenesis and tumor maintenance. However, despite their significance, there is currently no comprehensive characterization of CNS-PNETs BTICs. Recently, we described an animal model of CNS-PNET generated by orthotopic transplantation of human Radial Glial (RG) cells - the progenitor cells for adult neural stem cells (NSC) - into NOD-SCID mice brain and proposed that BTICs may play a role in the maintenance of these tumors...
March 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29559953/secretoneurin-a-directly-regulates-the-proteome-of-goldfish-radial-glial-cells-in-vitro
#17
Dillon F Da Fonte, Chris J Martyniuk, Lei Xing, Vance L Trudeau
Radial glial cells (RGCs) are the main macroglia in the teleost brain and have established roles in neurogenesis and neurosteroidogenesis. They are the only brain cell type expressing aromatase B ( cyp19a1b ), the enzyme that synthesizes estrogens from androgen precursors. There are few studies on the regulation of RGC functions, but our previous investigations demonstrated that dopamine stimulates cyp19a1b expression in goldfish RGCs, while secretoneurin A (SNa) inhibits the expression of this enzyme. Here, we determine the range of proteins and cellular processes responsive to SNa treatments in these steroidogenic cells...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29525995/neuronal-precursor-migration-in-ex-vivo-brain-slice-culture
#18
Fu-Sheng Chou, Pei-Shan Wang
Neuronal migration during fetal brain development is a well-coordinated process between the migrating neurons and their substrates, the basal processes of the radial glial cells (RGCs). The progeny-progenitor relationship between the migrating neurons and the RGCs in the developing fetal brain may make interpretations of the results difficult, because the variable in question may affect both the RGCs and the migrating neurons in different ways. A transplantation assay combining migrating cells and the scaffolding tissue from two different sources may circumvent this issue...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29514086/transcriptional-dysregulation-in-postnatal-glutamatergic-progenitors-contributes-to-closure-of-the-cortical-neurogenic-period
#19
Vanessa Donega, Guillaume Marcy, Quentin Lo Giudice, Stefan Zweifel, Diane Angonin, Roberto Fiorelli, Djoher Nora Abrous, Sylvie Rival-Gervier, Muriel Koehl, Denis Jabaudon, Olivier Raineteau
Progenitors of cortical glutamatergic neurons (Glu progenitors) are usually thought to switch fate before birth to produce astrocytes. We used fate-mapping approaches to show that a large fraction of Glu progenitors persist in the postnatal forebrain after closure of the cortical neurogenesis period. Postnatal Glu progenitors do not accumulate during embryonal development but are produced by embryonal radial glial cells that persist after birth in the dorsal subventricular zone and continue to give rise to cortical neurons, although with low efficiency...
March 6, 2018: Cell Reports
https://www.readbyqxmd.com/read/29495919/blood-glutamate-scavenger-as-a-novel-neuroprotective-treatment-in-spinal-cord-injury
#20
Yona Goldshmit, Ghil Jona, Eran Schmukler, Shira Solomon, Ronit Pinkas-Kramarski, Angela Ruban
Neurotrauma causes immediate elevation of extracellular glutamate (Glu) levels, which creates excitotoxicity and facilitates inflammation, glial scar formation, and consequently neuronal death. Finding factors that reduce the inflammatory response and glial scar formation, and increase neuronal survival and neurite outgrowth, are of major importance for improving the outcome after spinal cord injury (SCI). In the present study, we evaluated a new treatment aiming to remove central nervous system (CNS) Glu into the systemic blood circulation by intravenous (IV) administration of blood Glu scavengers (BGS) such as the enzyme recombinant glutamate-oxaloacetate transaminase 1 (rGOT1) and its co-substrate...
May 15, 2018: Journal of Neurotrauma
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