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https://www.readbyqxmd.com/read/29232160/microrna-145-antagonism-reverses-tgf-%C3%AE-inhibition-of-f508del-cftr-correction-in-airway-epithelia
#1
Farruk Lutful Kabir, Namasivayam Ambalavanan, Gang Liu, Peng Li, George M Solomon, Charitharth V Lal, Marina Mazur, Brian Halloran, Tomasz Szul, William T Gerthoffer, Steven M Rowe, William T Harris
INTRODUCTION: microRNAs (miRNAs) destabilize mRNA transcripts and inhibit protein translation. miR-145 is of particular interest in cystic fibrosis (CF) as it has a direct binding site in the 3'-untranslated region of CFTR and is upregulated by the CF genetic modifier TGF-β. HYPOTHESIS: miR-145 mediates TGF-β inhibition of CFTR synthesis and function in airway epithelia. METHODS: Primary human CF (F508del homozygous) and non-CF airway epithelial cells (AECs) were grown to terminal differentiation at air-liquid interface on permeable supports...
December 12, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29230506/the-isoprenoid-end-product-n6-isopentenyladenosine-reduces-inflammatory-response-through-the-inhibition-of-the-nf%C3%AE%C2%BAb-and-stat3-pathways-in-cystic-fibrosis-cells
#2
Antonietta Santoro, Elena Ciaglia, Vanessa Nicolin, Alessandra Pescatore, Lucia Prota, Mario Capunzo, Matilde V Ursini, Stefania L Nori, Maurizio Bifulco
OBJECTIVE: N6-isopentenyladenosine (iPA) is an intermediate of the mevalonate pathway that exhibits various anti-cancer effects. However, studies on its anti-inflammatory activity are scarce and underlying molecular mechanisms are unknown. Therefore, we aimed to investigate the ability of iPA to exert anti-inflammatory effects in the human cystic fibrosis (CF) cell model of exacerbated inflammation. MATERIALS AND METHODS: TNFα-stimulated CF cells CuFi-1 and its normal counterpart NuLi-1 were pre-treated with increasing concentrations of iPA and cell viability and proliferation were assessed by MTT and BrdU assays...
December 11, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29230333/celiac-disease-in-patients-with-cystic-fibrosis-related-bone-disease
#3
Melissa S Putman, Alexandra Haagensen, Isabel Neuringer, Leonard Sicilian
Both cystic fibrosis (CF) and celiac disease can cause low bone mineral density (BMD) and fractures. Celiac disease may occur at a higher frequency in patients with CF than the general population, and symptoms of these conditions may overlap. We report on two patients presenting with CF-related bone disease in the past year who were subsequently found to have concurrent celiac disease. Because adherence to a gluten-free diet may improve BMD in patients with celiac disease, this could have important implications for treatment...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/29229473/cystic-fibrosis-research-topics-featured-at-the-14th-ecfs-basic-science-conference-chairman-s-summary
#4
Marcus A Mall, Tzyh-Chang Hwang, Ineke Brakman
In recent years, tremendous progress has been made in the development of novel drugs targeting the basic defect in patients with cystic fibrosis (CF). This breakthrough is based on a solid foundation of knowledge on CFTR's function in health and how mutations in CFTR cause CF multi-organ disease. This knowledge has been collected and continuously expanded by an active and persistent CF research community and has paved the way for precision medicine for CF. Since 2004, the European Cystic Fibrosis Society (ECFS) has held an annual Basic Science Conference that has evolved as an international forum for interdisciplinary discussion of hot topics and unsolved questions related to CF research...
December 8, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29229257/factors-related-to-the-severity-of-early-postoperative-infection-after-heart-transplantation-in-patients-surviving-prolonged-mechanical-support-periods-experience-at-a-single-university
#5
Ryuichiro Abe, Sho C Shibata, Shunsuke Saito, Yasumasa Tsukamoto, Koichi Toda, Akinori Uchiyama, Yasushi Sakata, Yoshiki Sawa, Kazunori Tomono, Yuji Fujino
OBJECTIVE: The authors examined the effect of prolonged support with continuous-flow ventricular assist devices (CF-VADs) and other related factors on the severity of infections within 30 days of heart transplantation (HTx). DESIGN: A retrospective analysis of consecutive HTx procedures. SETTING: University hospital, between 2010 and 2016. PARTICIPANTS: A cohort of 53 heart transplantation recipients (median age, 38...
July 8, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29228933/pulmonary-exacerbations-and-clinical-outcomes-in-a-longitudinal-cohort-of-infants-and-preschool-children-with-cystic-fibrosis
#6
Jordana E Hoppe, Brandie D Wagner, Scott D Sagel, Frank J Accurso, Edith T Zemanick
BACKGROUND: Pulmonary exacerbations (PEx) in school aged children and adults with cystic fibrosis (CF) lead to increased morbidity and lung function decline. However, the effect of exacerbations in young children with CF is not fully understood. We sought to characterize the frequency and clinical impact of PEx in a pilot study of infants and pre-school aged children with CF. METHODS: Thirty young children with CF [median (range) 1.5 years (0.2-4.9)] were prospectively followed for 2 years...
December 11, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29228273/direct-detection-of-exophiala-and-scedosporium-species-in-sputa-of-patients-with-cystic-fibrosis
#7
Min Chen, Nahid Kondori, Shuwen Deng, A H G Gerrits van den Ende, M Lackner, Wanqing Liao, G S de Hoog
Detection of species of Exophiala and Scedosporium in the respiratory tracts of cystic fibrosis (CF) patients remains controversial because of highly variable results. The results of our study suggested a significantly higher prevalence and more complex colonization than previously estimated. Approximately 17% (27/162) of clinical sputum samples were found to be positive for Exophiala dermatitidis and 30% (49/162) were positive for Scedosporium apiospermum / S. boydii species complex determined by reverse line blot (RLB) hybridization...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29228063/what-matters-in-chronic-burkholderia-cenocepacia-infection-in-cystic-fibrosis-insights-from-comparative-genomics
#8
Jaroslav Nunvar, Vaclav Capek, Karel Fiser, Libor Fila, Pavel Drevinek
Burkholderia cenocepacia causes severe pulmonary infections in cystic fibrosis (CF) patients. Since the bacterium is virtually untreatable by antibiotics, chronic infections persist for years and might develop into fatal septic pneumonia (cepacia syndrome, CS). To devise new strategies to combat chronic B. cenocepacia infections, it is essential to obtain comprehensive knowledge about their pathogenesis. We conducted a comparative genomic analysis of 32 Czech isolates of epidemic clone B. cenocepacia ST32 isolated from various stages of chronic infection in 8 CF patients...
December 11, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29227801/an-efficient-and-cost-effective-tri-functional-electrocatalyst-based-on-cobalt-ferrite-embedded-nitrogen-doped-carbon
#9
Saad M Alshehri, Ameen N Alhabarah, Jahangeer Ahmed, Mu Naushad, Tansir Ahamad
The development of efficient, cost-effective and long-lived electro-catalyst is necessary for the realization of practically viable water-splitting systems. A trifunctional electrocatalyst for water splitting (hydrogen evolution, oxygen reduction and oxygen evolution reaction, HER/ORR/OER) was designed via eco-friendly and facial way. CoFe2O4 nanoparticles embedded in nitrogen doped mesoporous carbon were prepared using chicken egg white/albumin after pyrolysis at different temperatures, 700, 800, 900 and 1000 °C...
December 6, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29227276/alteration-in-the-cytokine-secretion-pattern-in-t-cells-of-patients-with-cystic-fibrosis-caused-by-dna-methyltransferase-inhibitor-5-azacitidine
#10
E Kvaratskhelia, N Dabrundashvili, M Gagua, E Maisuradze, M Kamkamidze, E Abzianidze
Cystic fibrosis (CF) is the autosomal-recessive disorder caused by mutation in the cystic fibrosis transmembrane conductance regulator gene (CFTR). The Airway inflammation plays a central role in the progression of CF disease. Cystic fibrosis characterized by the overproduction of the pro-inflammatory cytokines and reduced expression of anti-inflammatory cytokines. Although the mechanisms of abnormal cytokine expression is still poorly understood, altered epigenetic regulations in T cells might contribute. In the present study we examined the expression of IFN-γ and IL-10 by CF T cells prior to and following 5-azaC treatment...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29227188/clinical-strains-of-chryseobacterium-and-elizabethkingia-spp-isolated-from-pediatric-patients-in-a-university-hospital-performance-of-maldi-tof-ms-based-identification-antimicrobial-susceptibilities-and-baseline-patient-characteristics
#11
Hasan Cenk Mirza, Özlem Tuncer, Serpil Ölmez, Burçin Şener, Gökçen Dilşa Tuğcu, Uğur Özçelik, Nafia Canan Gürsoy, Barış Otlu, Ayşe Büyükçam, Ateş Kara, Banu Sancak
Our objective was to evaluate the performance of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) for identification of the Chryseobacterium and Elizabethkingia spp. isolated from pediatric patients at Hacettepe University Hospital using 16S rRNA gene sequencing as the gold standard and to determine the antimicrobial susceptibility patterns of the isolates and baseline characteristics of patients. All stored Chryseobacterium and Elizabethkingia spp. isolated from various clinical specimens (sputum, blood, and urine) of pediatric patients at Hacettepe University Hospital between 2012 and 2016 were included in this study...
December 11, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29227169/descriptive-study-of-the-relationship-between-the-subclinical-carotid-disease-and-biomarkers-carotid-femoral-pulse-wave-velocity-in-patients-with-hypertension
#12
XiaoXiao Zhao, Liujin Bo, Hongwei Zhao, Lihong Li, Yingyan Zhou, Hongyu Wang
BACKGROUND: Carotid intima-media thickness (cIMT) is a significant early prediction signal for preclinical atherosclerosis. Plasma homocysteine (Hcy) level is an independent risk factor for cardiovascular diseases. Pulse wave velocity (PWV), an index of arterial stiffness (AS), has showed its value in the evaluation of AS in vascular-related diseases. The data regarding the relationships between cIMT and other indices of vascular damage are limited and partly controversial. We aim to investigate the relationships between cIMT and other indices of vascular damage such as Hcy and carotid femoral PWV (CF-PWV)...
December 11, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29227154/pose-determination-of-a-blade-implant-in-three-dimensions-from-a-single-two-dimensional-radiograph
#13
Toti Paolo, Barone Antonio, Marconcini Simone, Menchini-Fabris Giovanni Battista, Martuscelli Ranieri, Covani Ugo
OBJECTIVES: The aim of the study was to introduce a mathematical method to estimate the correct pose of a blade by evaluating the radiographic features obtained from a single two-dimensional image. METHODS: Blade-form implant bed preparation was performed using the piezosurgery device, and placement was attained with the use of magnetic mallet. The pose determination of the blade was described by means of three consecutive rotations defined by three angles of orientation (triplet φ, θ and Ψ)...
December 11, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/29226186/prevalence-of-pelvic-incontinence-in-patients-with-cystic-fibrosis
#14
Fatima Neemuchwala, Fahmida Ahmed, Samya Z Nasr
Cystic fibrosis (CF) patients are at risk for developing pelvic (urinary and/or fecal) incontinence due to progressive weakness of pelvic floor muscles secondary to recurrent episodes of coughing and respiratory infections. Many patients do not bring these symptoms to the attention of their health care providers because of social embarrassment and lack of knowledge of available effective treatment. Several studies have identified the prevalence of incontinence in CF adults and adolescents. However, few studies identified the problem in children with CF...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/29225856/severe-piperacillin-tazobactam-induced-hemolysis-in-a-cystic-fibrosis-patient
#15
Andrew D Kerkhoff, Lauren Patrick, Patricia Cornett, Mary-Ellen Kleinhenz, Sam Brondfield
Piperacillin-tazobactam is one of the most common causes of drug-induced immune hemolytic anemia (DIIHA) and is frequently utilized, especially in patients with cystic fibrosis (CF). Here, we report a case of life-threatening piperacillin-tazobactam-associated DIIHA in a 30-year-old woman with CF and propose management recommendations for piperacillin-tazobactam-associated DIIHA in CF patients.
December 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29225693/cytoreductive-prostate-radiotherapy-in-oligometastatic-prostate-cancer-a-single-centre-analysis-of-toxicity-and-clinical-outcome
#16
Giulia Riva, Giulia Marvaso, Matteo Augugliaro, Dario Zerini, Cristiana Fodor, Gennaro Musi, Ottavio De Cobelli, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
Objectives: The current standard of care for patients with metastatic prostate cancer (mPCa) at diagnosis is androgen deprivation therapy (ADT) with or without anti-androgen and chemotherapy. The aim of this study was to define the role of a local radiotherapy (RT) treatment in the mPCa setting. Methods: We retrospectively reviewed data of patients with PCa and bone oligometastases at diagnosis treated in our institution with ADT followed by cytoreductive prostate-RT with or without RT on metastases...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29225413/outbreak-of-hospital-infection-from-biofilm-embedded-pan-drug-resistant-pseudomonas-aeroginosa-due-to-a-contaminated-bronchoscope
#17
Nader Alipour, Alper Karagoz, Abbas Taner, Nasrin Gaeini, Nastaran Alipour, Hassan Zeytin, Fatih Yildiz, Riza Durmaz
Background: Colistin-resistant Pseudomonas aeruginosa (P. aeruginosa) has been defined as pandrug-resistant (PDR) strain. Outbreaks of PDR P. aeruginosa especially in pulmonary tract infections due to contaminated bronchoscopes have rarely been reported. The emergence of pandrug-resistant strains in both CF (Cystic Fibrosis) and non-CF clinical isolates over recent years remains of a great concern. Hospital wards contaminated with PDR P. aeruginosa infection, must be shot down until their eradication...
2017: Tap Chi y Hoc du Phong, Journal of Preventive Medicine / Hoi y Hoc du Phong Viet Nam
https://www.readbyqxmd.com/read/29224788/long-term-intestinal-obstruction-sequelae-and-growth-in-children-with-cystic-fibrosis-operated-for-meconium-ileus-expectancies-and-surprises
#18
Anastasia Mentessidou, Ioanna Loukou, Georgios Kampouroglou, Anastasia Livani, Ioannis Georgopoulos, Petros Mirilas
BACKGROUND/PURPOSE: In the few studies on intestinal complications and growth of cystic fibrosis (CF) patients with a history of meconium ileus (MI), operated MI has not been investigated separately. We aimed to investigate the incidence of long-term intestinal obstruction sequelae [constipation, distal intestinal obstruction syndrome (DIOS)] and growth in CF patients operated for MI. METHODS: Retrospective study (1989-2016) including operative diagnoses and procedures, constipation and DIOS events, yearly Body Mass Index (BMI) measurements...
November 15, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29222447/structural-abnormalities-in-islets-from-very-young-children-with-cystic-fibrosis-may-contribute-to-cystic-fibrosis-related-diabetes
#19
Marika Bogdani, Scott M Blackman, Cecilia Ridaura, Jean-Pierre Bellocq, Alvin C Powers, Lydia Aguilar-Bryan
Cystic fibrosis (CF)-related diabetes (CFRD) is thought to result from beta-cell injury due in part to pancreas exocrine damage and lipofibrosis. CFRD pancreata exhibit reduced islet density and altered cellular composition. To investigate a possible etiology, we tested the hypothesis that such changes are present in CF pancreata before the development of lipofibrosis. We evaluated pancreas and islet morphology in tissues from very young CF children (<4 years of age), and adult patients with CF and CFRD...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222072/heparan-sulfate-potentiates-leukocyte-adhesion-on-cardiac-fibroblast-by-enhantcing-vcam-1-and-icam-1-expression
#20
Francisco Olivares-Silva, Rodolfo Landaeta, Pablo Aránguiz, Samir Bolivar, Claudio Humeres, Renatto Anfossi, Raúl Vivar, Pía Boza, Claudia Muñoz, Viviana Pardo-Jiménez, Concepción Peiró, Carlos F Sánchez-Ferrer, Guillermo Díaz-Araya
Cardiac fibroblasts (CF) act as sentinel cells responding to chemokines, cytokines and growth factors released in cardiac tissue in cardiac injury events, such as myocardial infarction (MI). Cardiac injury involves the release of various damage-associated molecular patterns (DAMPs) including heparan sulfate (HS), a constituent of the extracellular matrix (ECM), through the TLR4 receptor activation triggering a strong inflammatory response, inducing leukocytes recruitment. This latter cells are responsible of clearing cell debris and releasing cytokines that promote CF differentiation to myofibroblast (CMF), thus initiating scar formation...
December 5, 2017: Biochimica et Biophysica Acta
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