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https://www.readbyqxmd.com/read/28333579/anaerobic-digestion-of-thermal-alkaline-pretreated-cephalosporin-bacterial-residues-for-methane-production
#1
Guixia Li, Weizhang Zhong, Rui Wang, Jiaqi Chen, Zaixing Li
Optimum anaerobic conditions of ephalosporin bacterial residues after thermal-alkaline pretreatment were determined by orthogonal experiments. And through biochemical methane potential tests (BMPs) for cephalosporin bacterial residues, the ability for bacterial degradation of cephalosporin was also evaluated. The thermal-alkaline pretreatment with the optimum values of 6% NaOH at 105°C for 15 min significantly improved digestion performance. With the thermal-alkaline pretreatment, the specific methane yield of the pretreated cephalosporin bacterial residue increased by 254...
March 23, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28324851/assessing-the-impacts-of-best-management-practices-on-nitrate-pollution-in-an-agricultural-dominated-lowland-catchment-considering-environmental-protection-versus-economic-development
#2
Marcelo B Haas, Björn Guse, Nicola Fohrer
Water quality is strongly affected by nitrate inputs in agricultural catchments. Best Management Practices (BMPs) are alternative practices aiming to mitigate the impacts derived from agricultural activities and to improve water quality. Management activities are influenced by different governmental policies like the Water Framework Directive (WFD) and the Renewable Energy Sources Act (EEG). Their distinct goals can be contrasting and hamper an integrated sustainable development. Both need to be addressed in the actual conjuncture in rural areas...
March 15, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28315798/bone-morphogenetic-proteins-in-anterior-cervical-fusion-a-systematic-review-and-meta-analysis
#3
REVIEW
Shayan Abdollah Zadegan, Aidin Abedi, Seyed Behnam Jazayeri, Hirbod Nasiri Bonaki, Seyed Behzad Jazayeri, Alexander R Vaccaro, Vafa Rahimi-Movaghar
OBJECTIVE: Bone morphogenetic proteins (BMPs) have been commonly used as a graft substitute in spinal fusion. Although the Food and Drug Administration (FDA) issued warning on life-threatening complications of recombinant human BMPs (rhBMPs) in cervical spine fusion in 2008, their off-label use has been continued. This investigation aimed to review the evidence for the use of rhBMP-2 and rhBMP-7 in anterior cervical spine fusions. METHODS: A comprehensive search was performed through Ovid (MEDLINE), PubMed and Embase...
March 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28303752/bone-morphogenetic-proteins-and-dickkopf-1-in-ankylosing-spondylitis
#4
H-T Liao, Y-F Lin, C-Y Tsai, T-C Chou
OBJECTIVES: To determine bone morphogenetic proteins (BMPs) and Dickkopf homologue-1 (Dkk-1) levels in ankylosing spondylitis (AS). METHOD: Serum BMPs and Dkk-1 were measured in 72 AS patients and 30 healthy controls. For AS patients, we recorded the demographic data, disease activity, functional index, and global assessment with questionnaires, and image changes with roentgenography. We also measured human leucocyte antigen-B27 and systemic inflammatory reactants...
March 17, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28283405/coordination-of-limb-development-by-crosstalk-among-axial-patterning-pathways
#5
REVIEW
Irene Delgado, Miguel Torres
Vertebrate limb development relies on the activity of signaling centers that promote growth and control patterning along three orthogonal axes of the limb bud. The apical ectodermal ridge, at the distal rim of the limb bud ectoderm, produces WNT and FGF signals, which promote limb bud growth and progressive distalization. The zone of polarizing activity, a discrete postero-distal mesenchymal domain, produces SHH, which stimulates growth and organizes patterning along the antero-posterior axis. The dorsal and ventral ectoderms produce, respectively, WNT7A and BMPs, which induce dorso-ventral limb fates...
March 7, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28283030/impaired-osteogenesis-of-t1dm-bone-marrow-derived-stromal-cells-and-periosteum-derived-cells-and-their-differential-in-vitro-responses-to-growth-factor-rescue
#6
Tera M Filion, Jordan D Skelly, Henry Huang, Dale L Greiner, David C Ayers, Jie Song
BACKGROUND: Poor bone quality, increased fracture risks, and impaired bone healing are orthopedic comorbidities of type 1 diabetes (T1DM). Standard osteogenic growth factor treatments are inadequate in fully rescuing retarded healing of traumatic T1DM long bone injuries where both periosteal and bone marrow niches are disrupted. We test the hypotheses that osteogenesis of bone marrow-derived stromal cells (BMSCs) and periosteum-derived cells (PDCs), two critical skeletal progenitors in long bone healing, are both impaired in T1DM and that they respond differentially to osteogenic bone morphogenetic proteins (BMPs) and/or insulin-like growth factor-1 (IGF-1) rescue...
March 11, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28283003/bacterial-magnetic-particles-improve-testes-mediated-transgene-efficiency-in-mice
#7
COMPARATIVE STUDY
Chao Wang, Guanghong Sun, Ye Wang, Nana Kong, Yafei Chi, Leilei Yang, Qiliang Xin, Zhen Teng, Xu Wang, Yujun Wen, Ying Li, Guoliang Xia
Nano-scaled materials have been proved to be ideal DNA carriers for transgene. Bacterial magnetic particles (BMPs) help to reduce the toxicity of polyethylenimine (PEI), an efficient gene-transferring agent, and assist tissue transgene ex vivo. Here, the effectiveness of the BMP-PEI complex-conjugated foreign DNAs (BPDs) in promoting testes-mediated gene transfer (TMGT) in mouse was compared with that of liposome-conjugated foreign DNAs. The results proved that through testes injection, the clusters of BPDs successfully reached the cytoplasm and the nuclear of spermatogenesis cell, and expressed in testes of transgene founder mice...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28260028/gremlin-1-suppression-increases-bmp-2-induced-osteogenesis-of-human-mesenchymal-stem-cells
#8
Kongzu Hu, Heyan Sun, Binjie Gui, Cong Sui
Previous research focusing on rodent cells and animal models has demonstrated that gremlin-1 antagonizes bone morphogenetic proteins (BMPs) in order to suppress osteogenesis. However, the impact of gremlin‑1 on osteogenesis in human bone marrow-derived mesenchymal stem cells (MSCs) remains unknown. The aim of the present study was to test the effects of gremlin-1 on viability and in vitro BMP-2-induced osteogenic differentiation of human bone marrow‑derived mesenchymal stem cells (MSCs). Gremlin‑1‑specific small interfering RNA (siRNA) inhibited gremlin‑1 mRNA and protein expression in human MSCs...
February 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28260001/icaritin-a-novel-plant-derived-osteoinductive-agent-enhances-the-osteogenic-differentiation-of-human-bone-marrow-and-human-adipose-tissue-derived-mesenchymal-stem-cells
#9
Tao Wu, Tao Shu, Le Kang, Jinhui Wu, Jianzhou Xing, Zhiqin Lu, Shuxiang Chen, Jun Lv
For the treatment of diseases affecting bones using bone regenerative medicine, there is an urgent need to develop safe, inexpensive drugs that can strongly induce bone formation. In the present study, we systematically investigated the effects of icaritin, a metabolic product of icariin, on the osteogenic differentiation of human bone marrow‑derived mesenchymal stem cells (hBMSCs) and human adipose tissue‑derived stem cells (hADSCs) in vitro. After treatment with icaritin at concentrations of 10‑8-10‑5 M, hBMSCs and hADSCs were examined for alkaline phosphatase activity, osteocalcin (OC) secretion, matrix mineralization and expression levels of bone‑related mRNA and proteins...
February 24, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28250237/bovine-embryo-oviduct-interaction-in-vitro-reveals-an-early-crosstalk-mediated-by-bmp-signaling
#10
Elina Vanesa García, Meriem Hamdi, Antonio Daniel Barrera, Maria-Jesús Sánchez Calabuig, Alfonso Gutierrez-Adan, Dimitrios Rizos
Signaling components of Bone Morphogenetic Proteins (BMPs) are expressed in an anatomically and temporally regulated fashion in bovine oviduct. However, a local response of this signaling to the presence of the embryo has yet to be elucidated. The aim of the present study was to evaluate if early embryo-oviduct interaction induces changes in the gene expression of BMP signaling components. For this purpose, we used an in vitro co-culture system to investigate the local interaction between bovine oviductal epithelial cells (BOEC) from the isthmus region with early embryos during two developmental periods: before (from the 2-cell to 8-cell stage) or during (from the 8-cell to 16-cell stage) the main phase of embryonic genome activation (EGA)...
March 1, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28249802/bone-morphogenetic-proteins-in-multiple-sclerosis-role-in-neuroinflammation
#11
REVIEW
Herena Eixarch, Laura Calvo-Barreiro, Xavier Montalban, Carmen Espejo
Bone morphogenetic proteins (BMPs) are growth factors that represent the largest subgroup of signalling ligands of the transforming growth factor beta (TGF-β) superfamily. Their participation in the proliferation, survival and cell fate of several cell types and their involvement in many pathological conditions are now well known. BMP expression is altered in multiple sclerosis (MS) patients, suggesting that BMPs have a role in the pathogenesis of this disease. MS is a demyelinating and neurodegenerative autoimmune disorder of the central nervous system (CNS)...
February 27, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28246187/tgf-%C3%AE-family-signaling-in-connective-tissue-and-skeletal-diseases
#12
Elena Gallo MacFarlane, Julia Haupt, Harry C Dietz, Eileen M Shore
The transforming growth factor β (TGF-β) family of signaling molecules, which includes TGF-βs, activins, inhibins, and numerous bone morphogenetic proteins (BMPs) and growth and differentiation factors (GDFs), has important functions in all cells and tissues, including soft connective tissues and the skeleton. Specific TGF-β family members play different roles in these tissues, and their activities are often balanced with those of other TGF-β family members and by interactions with other signaling pathways...
February 28, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28246184/tgf-%C3%AE-family-signaling-in-epithelial-differentiation-and-epithelial-mesenchymal-transition
#13
Kaoru Kahata, Mahsa Shahidi Dadras, Aristidis Moustakas
Epithelia exist in the animal body since the onset of embryonic development; they generate tissue barriers and specify organs and glands. Through epithelial-mesenchymal transitions (EMTs), epithelia generate mesenchymal cells that form new tissues and promote healing or disease manifestation when epithelial homeostasis is challenged physiologically or pathologically. Transforming growth factor-βs (TGF-βs), activins, bone morphogenetic proteins (BMPs), and growth and differentiation factors (GDFs) have been implicated in the regulation of epithelial differentiation...
February 28, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28215811/intra-annual-variation-of-the-association-between-agricultural-best-management-practices-and-stream-nutrient-concentrations
#14
Nolan J T Pearce, Adam G Yates
Temporal variation may influence the ability of best management practices (BMPs) to mitigate the loss of agricultural pollutants to streams. Our goal was to assess variation in mitigation effects of BMPs by examining the associations between instream nutrient concentrations and the abundance and location of four structural BMPs over a hydrologic year. Water samples were collected monthly (Nov. 2013-Oct. 2014) in 15 headwater streams representing a gradient of BMP use in Southern Ontario, Canada. Partial least squares (PLS) regression models were used to associate two groups of collinear nutrient forms with the abundance and location of BMPs, antecedent precipitation and time of year...
May 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28214472/bmp-12-activates-tenogenic-pathway-in-human-adipose-stem-cells-and-affects-their-immunomodulatory-and-secretory-properties
#15
Weronika Zarychta-Wiśniewska, Anna Burdzinska, Agnieszka Kulesza, Kamila Gala, Beata Kaleta, Katarzyna Zielniok, Katarzyna Siennicka, Marek Sabat, Leszek Paczek
BACKGROUND: Cell-based therapy is a treatment method in tendon injuries. Bone morphogenic protein 12 (BMP-12) possesses tenogenic activity and was proposed as a differentiating factor for stem cells directed to transplantation. However, BMPs belong to pleiotropic TGF-β superfamily and have diverse effect on cells. Therefore, the aim of this study was to determine if BMP-12 induces tenogenic differentiation of human adipose stem cells (hASCs) and how it affects other features of this population...
February 18, 2017: BMC Cell Biology
https://www.readbyqxmd.com/read/28211679/site-directed-immobilization-of-bmp-2-two-approaches-for-the-production-of-innovative-osteoinductive-scaffolds
#16
Barbara Tabisz, Werner Schmitz, Michael Schmitz, Tessa Luehmann, Eva Heusler, Jens-Christoph Rybak, Lorenz Meinel, Juliane E Fiebig, Thomas D Mueller, Joachim Nickel
The regenerative potential of bone is strongly impaired in pathological conditions, such as nonunion fractures. To support bone regeneration various scaffolds have been developed in the past, which have been functionalized with osteogenic growth factors such as bone morphogenetic proteins (BMPs). However, most of them required supra-physiological levels of these proteins leading to burst releases, thereby causing severe side effects. Site-specific, covalent coupling of BMP2 to implant materials might be an optimal strategy in order to overcome these problems...
March 13, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28202671/extracellular-regulation-of-bmp-signaling-welcome-to-the-matrix
#17
REVIEW
Georg Sedlmeier, Jonathan P Sleeman
Given its importance in development and homeostasis, bone morphogenetic protein (BMP) signaling is tightly regulated at the extra- and intracellular level. The extracellular matrix (ECM) was initially thought to act as a passive mechanical barrier that sequesters BMPs. However, a new understanding about how the ECM plays an instructive role in regulating BMP signaling is emerging. In this mini-review, we discuss various ways in which the biochemical and physical properties of the ECM regulate BMP signaling.
February 8, 2017: Biochemical Society Transactions
https://www.readbyqxmd.com/read/28202082/bone-morphogenetic-proteins-and-myostatin-pathways-key-mediator-of-human-sarcopenia
#18
Manuel Scimeca, Eleonora Piccirilli, Francesca Mastrangeli, Cecilia Rao, Maurizio Feola, Augusto Orlandi, Elena Gasbarra, Elena Bonanno, Umberto Tarantino
BACKGROUND: Sarcopenia, osteoporosis and osteoarthritis are the most frequent musculoskeletal disorders affecting older people. The main aim of this study was to test the hypothesis that the balance between BMPs and myostatin pathways regulates the age-related muscle degeneration in OP and OA patients. To this end, we investigated the relationship among the expression of BMP-2/4-7, myostatin and phosphorylated Smads1-5-8 and the muscle quality, evaluated in term of fibers atrophy and satellite cells activity...
February 15, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28199877/characterising-stormwater-gross-pollutants-captured-in-catch-basin-inserts
#19
Md Zahanggir Alam, A H M Faisal Anwar, Dipok Chandra Sarker, Anna Heitz, Craig Rothleitner
The accumulation of wash-off solid waste, termed gross pollutants (GPs), in drainage systems has become a major constraint for best management practices (BMPs) of stormwater. GPs should be captured at source before the material clogs the drainage network, seals the infiltration capacity of side entry pits or affects the aquatic life in receiving waters. BMPs intended to reduce stormwater pollutants include oil and grit separators, grassed swales, vegetated filter strips, retention ponds, and catch basin inserts (CBIs) are used to remove GP at the source and have no extra land use requirement because they are typically mounted within a catch basin (e...
May 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28197209/effect-of-bmp-2-delivery-mode-on-osteogenic-differentiation-of-stem-cells
#20
Taekhee Jung, John Hwan Lee, Soonjung Park, Yong-Jin Kim, Joseph Seo, Hye-Eun Shim, Ki-Suk Kim, Hyon-Seok Jang, Hyung-Min Chung, Seong-Geun Oh, Sung-Hwan Moon, Sun-Woong Kang
Differentiation of stem cells is an important strategy for regeneration of defective tissue in stem cell therapy. Bone morphogenetic protein-2 (BMP-2) is a well-known osteogenic differentiation factor that stimulates stem cell signaling pathways by activating transmembrane type I and type II receptors. However, BMPs have a very short half-life and may rapidly lose their bioactivity. Thus, a BMP delivery system is required to take advantage of an osteoinductive effect for osteogenic differentiation. Previously, BMP delivery has been designed and evaluated for osteogenic differentiation, focusing on carriers and sustained release system for delivery of BMPs...
2017: Stem Cells International
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