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https://www.readbyqxmd.com/read/29333367/stepwise-verification-of-bone-regeneration-using-recombinant-human-bone-morphogenetic-protein-2-in-rat-fibula-model
#1
Jung-Woo Nam, Hyung-Jun Kim
Objectives: The purpose of this study was to introduce our three experiments on bone morphogenetic protein (BMP) and its carriers performed using the critical sized segmental defect (CSD) model in rat fibula and to investigate development of animal models and carriers for more effective bone regeneration. Materials and Methods: For the experiments, 14, 16, and 24 rats with CSDs on both fibulae were used in Experiments 1, 2, and 3, respectively. BMP-2 with absorbable collagen sponge (ACS) (Experiments 1 and 2), autoclaved autogenous bone (AAB) and fibrin glue (FG) (Experiment 3), and xenogenic bone (Experiment 2) were used in the experimental groups...
December 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/29324456/targeted-knockdown-of-bone-morphogenetic-protein-signaling-within-neural-progenitors-protects-the-brain-and-improves-motor-function-following-postnatal-hypoxia-ischemia
#2
Robert W Dettman, Derin Birch, Augusta Fernando, John A Kessler, Maria L V Dizon
Hypoxic-ischemic injury (HI) to the neonatal human brain results in myelin loss that, in some children, can manifest as cerebral palsy. Previously, we had found that neuronal overexpression of the bone morphogenic protein (BMP) inhibitor noggin during development increased oligodendroglia and improved motor function in an experimental model of HI utilizing unilateral common carotid artery ligation followed by hypoxia. As BMPs are known to negatively regulate oligodendroglial fate specification of neural stem cells and alter differentiation of committed oligodendroglia, BMP signaling is likely an important mechanism leading to myelin loss...
January 12, 2018: Developmental Neuroscience
https://www.readbyqxmd.com/read/29322862/feasibility-of-developing-a-passive-sampler-for-sampling-heavy-metals-in-bmps-for-stormwater-runoff-management
#3
Yueqin Dou, Mitch Klein, Tian C Zhang, John Stansbury, Massoum Moussavi, Dana L Richter-Egger, Jing Zeng
Structural Best Management Practices (BMPs) have been used for stormwater treatment and management for several decades. How to monitor these BMPs performance reliably and economically is a challenge. This paper reports feasibility of developing a flow through passive sampler (PS) based on Amberlite IRC748 ion exchange resin operated in kinetic regime for sampling heavy metals in BMPs (infiltration systems) for stormwater treatment and management. Tests were conducted using batch reactors and laboratory-scale BMPs (bioretention cells)...
January 11, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29321139/bmp-smad-pathway-promotes-neurogenesis-of-midbrain-dopaminergic-neurons-in-vivo-and-in-human-induced-pluripotent-and-neural-stem-cells
#4
V M Jovanovic, A Salti, H Tilleman, K Zega, M M Jukic, H Zou, R H Friedel, N Prakash, S Blaess, F Edenhofer, C Brodski
The embryonic formation of midbrain dopaminergic (mDA) neurons in vivo provides critical guidelines for the in vitro differentiation of mDA neurons from stem cells, currently being developed for Parkinson's disease cell replacement therapy. Bone morphogenetic protein (BMP)/SMAD inhibition is routinely used during early steps of stem cell differentiation protocols, including for the generation of mDA neurons. However, the function of the BMP/SMAD pathway for in vivo specification of mammalian mDA neurons is virtually unknown...
January 10, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29317497/identification-of-direct-negative-crosstalk-between-the-slit2-and-bone-morphogenetic-protein-gremlin-signaling-pathways
#5
Kathleen E Tumelty, Nathan Higginson-Scott, Xueping Fan, Piyush Bajaj, Kelly M Knowlton, Michael Shamashkin, Anthony J Coyle, Weining Lu, Stephen P Berasi
Slit guidance ligand 2 (SLIT2) is a large, secreted protein which binds roundabout (ROBO) receptors on multiple cell types including neurons and kidney podocytes. SLIT2-ROBO2 mediated signaling regulates neuronal migration and ureteric bud (UB) outgrowth during kidney development as well as glomerular filtration in adult kidneys. Additionally, SLIT2 binds Gremlin, an antagonist of bone morphogenetic proteins (BMPs), and BMP-Gremlin signaling also regulates UB formation. However, direct crosstalk between the ROBO2-SLIT2 and BMP-Gremlin signaling pathways has not been established...
January 9, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29295498/bmp-signalling-at-the-crossroad-of-liver-fibrosis-and-regeneration
#6
REVIEW
Blanca Herrera, Annalisa Addante, Aránzazu Sánchez
Bone Morphogenetic Proteins (BMPs) belong to the Transforming Growth Factor-β (TGF-β) family. Initially identified due to their ability to induce bone formation, they are now known to have multiple functions in a variety of tissues, being critical not only during development for tissue morphogenesis and organogenesis but also during adult tissue homeostasis. This review focus on the liver as a target tissue for BMPs actions, devoting most efforts to summarize our knowledge on their recently recognized and/or emerging roles on regulation of the liver regenerative response to various insults, either acute or chronic and their effects on development and progression of liver fibrosis in different pathological conditions...
December 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29285071/bmp-7-accelerates-the-differentiation-of-rabbit-mesenchymal-stem-cells-into-cartilage-through-the-wnt-%C3%AE-catenin-pathway
#7
Hong-Dan Fu, Hai-Rui Wang, Dai-He Li
Mesenchymal stem cells (MSCs) are able to differentiate into adipocytes, chondroblasts or cartilage under different stimulation conditions. Identifying a mechanism that triggers the differentiation of MSCs into cartilage may help the development of novel therapeutic approaches for heterotopic ossification, the pathological formation of lamellar bone in soft tissue outside the skeleton that may lead to debilitating immobility. Bone morphogenetic proteins (BMPs), including BMP-7, are the most potent growth factors for enhancing bone formation...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29282685/key-factors-in-breast-cancer-dissemination-and-establishment-at-the-bone-past-present-and-future-perspectives
#8
Sioned Owen, Catherine Zabkiewicz, Lin Ye, Andrew J Sanders, Chang Gong, Wen G Jiang
Bone metastases associated with breast cancer remain a clinical challenge due to their associated morbidity, limited therapeutic intervention and lack of prognostic markers. With a continually evolving understanding of bone biology and its dynamic microenvironment, many potential new targets have been proposed. In this chapter, we discuss the roles of well-established bone markers and how their targeting, in addition to tumour-targeted therapies, might help in the prevention and treatment of bone metastases...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29277722/the-pathogenic-roles-of-heparan-sulfate-deficiency-in-hereditary-multiple-exostoses
#9
REVIEW
Maurizio Pacifici
Heparan sulfate (HS) is an essential component of cell surface and matrix proteoglycans (HS-PGs) that include syndecans and perlecan. Because of their unique structural features, the HS chains are able to specifically interact with signaling proteins -including bone morphogenetic proteins (BMPs)- via their HS-binding domain, regulating protein availability, distribution and action on target cells. Hereditary Multiple Exostoses (HME) is a rare pediatric disorder linked to germline heterozygous loss-of-function mutations in EXT1 or EXT2 that encode Golgi-resident glycosyltransferases responsible for HS synthesis, resulting in a systemic HS deficiency...
December 22, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29273986/evaluation-of-the-methods-for-quantifying-particle-wash-off-loadings-in-urban-impervious-surfaces-at-small-scales
#10
Xi Luo, Hongtao Zhao, Yunjie Liao, Xuyong Li
Quantifying road-deposited sediment (RDS) wash-off is critical in estimating pollutant load and for supporting the designs of urban storm water low-impact development (LID) best management practices (BMPs). The objective of this study was to identify a simple and effective small-scale wash-off load estimation and prediction method suitable for BMP engineering. The reliabilities, complexities, and applicabilities of four prediction methods (i.e., the event mean concentration (EMC) equation method, the exponential equation method, and the RDS mass difference before and after rainfall event method, and the RDS index model) were tested for three sites (i...
December 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29273837/diaphyseal-long-bone-nonunions-types-aetiology-economics-and-treatment-recommendations
#11
REVIEW
Markus Rupp, Christoph Biehl, Matthäus Budak, Ulrich Thormann, Christian Heiss, Volker Alt
The intention of the current article is to review the epidemiology with related socioeconomic costs, pathophysiology, and treatment options for diaphyseal long bone delayed unions and nonunions. Diaphyseal nonunions in the tibia and in the femur are estimated to occur 4.6-8% after modern intramedullary nailing of closed fractures with an even much higher risk in open fractures. There is a high socioeconomic burden for long bone nonunions mainly driven by indirect costs, such as productivity losses due to long treatment duration...
December 22, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29259971/alk1fc-suppresses-the-human-prostate-cancer-growth-in-in-vitro-and-in-vivo-preclinical-models
#12
Letizia Astrologo, Eugenio Zoni, Sofia Karkampouna, Peter C Gray, Irena Klima, Joël Grosjean, Marie J Goumans, Lukas J A C Hawinkels, Gabri van der Pluijm, Martin Spahn, George N Thalmann, Peter Ten Dijke, Marianna Kruithof-de Julio
Prostate cancer is the second most common cancer in men and lethality is normally associated with the consequences of metastasis rather than the primary tumor. Therefore, targeting the molecular pathways that underlie dissemination of primary tumor cells and the formation of metastases has a great clinical value. Bone morphogenetic proteins (BMPs) play a critical role in tumor progression and this study focuses on the role of BMP9- Activin receptor-Like Kinase 1 and 2 (ALK1 and ALK2) axis in prostate cancer...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29258883/cartilage-regeneration-and-ageing-targeting-cellular-plasticity-in-osteoarthritis
#13
REVIEW
Marta Varela-Eirin, Jesus Loureiro, Eduardo Fonseca, Silvia Corrochano, Jose R Caeiro, Manuel Collado, Maria D Mayan
Ageing processes play a major contributing role for the development of Osteoarthritis (OA). This prototypic degenerative condition of ageing is the most common form of arthritis and is accompanied by a general decline, chronic pain and mobility deficits. The disease is primarily characterized by articular cartilage degradation, followed by subchondral bone thickening, osteophyte formation, synovial inflammation and joint degeneration. In the early stages, osteoarthritic chondrocytes undergo phenotypic changes that increase cell proliferation and cluster formation and enhance the production of matrix-remodelling enzymes...
December 16, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/29250330/bbp-functionalized-biomimetic-nanofibrous-scaffold-can-capture-bmp2-and-promote-osteogenic-differentiation
#14
Qingqing Yao, Eric S Sandhurst, Yangxi Liu, Hongli Sun
Bone morphogenetic proteins (BMPs, e.g., BMP2 and 7) are potent mediators for bone repair, however, their clinical use has been limited by their safety and cost-effectiveness. Therefore, innovative strategies that can improve the efficacy of BMPs, and thereby, use a lower dose of exogenous BMPs are highly desired. Inspired by the natural interaction between extracellular matrix (ECM) and growth factors, we hypothesize that bone matrix-mimicking nanofibrous scaffold functionalized with BMP binding moieties can selectively capture and stabilize BMPs, and thereby, promote BMP-induced osteogenic differentiation...
2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29248483/dose-dependent-resorption-of-allograft-by-rhbmp-2-uncompensated-by-new-bone-formation-a-canine-study-with-implants-and-zoledronate
#15
Rasmus Cleemann, Joan E Bechtold, Mette Sorensen, Kjeld Soballe, Jorgen Baas
BACKGROUND: Impacted bone allograft is used to restore lost bone in total joint arthroplasties. Bone morphogenetic proteins (BMPs) can induce new bone formation to improve allograft incorporation, but they simultaneously invoke a seemingly dose-dependent allograft resorption mediated by osteoclasts. Bisphosphonates effectively inhibit osteoclast activity. Predicting allograft resorption when augmented with bone morphogenetic protein 2 (BMP-2), we intended to investigate whether a balanced bone metabolism was achievable within a range of BMP-2 doses with systemic zoledronate treatment...
November 16, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29234727/the-dual-role-of-bone-morphogenetic-proteins-in-cancer
#16
REVIEW
Duc-Hiep Bach, Hyen Joo Park, Sang Kook Lee
Bone morphogenetic proteins (BMPs) are a diverse class of molecules with over 20 growth factor proteins that belong to the transforming growth factor-β (TGF-β) family and are highly associated with bone formation and disease development. Aberrant expression of various BMPs has been reported in several cancer tissues. Biological function studies have elicited the dual role of BMPs in both cancer development and suppression. Furthermore, a variety of BMP antagonists, ligands, and receptors have been shown to reduce or enhance tumorigenesis and metastasis...
March 30, 2018: Molecular Therapy Oncolytics
https://www.readbyqxmd.com/read/29227562/crosstalk-between-substance-p-and-calcitonin-gene-related-peptide-during-heterotopic-ossification-in-murine-achilles-tendon
#17
Ceren Tuzmen, Kostas Verdelis, Lee Weiss, Phil Campbell
Heterotopic ossification (HO) is abnormal bone formation within soft tissue, usually predisposed by neurogenic or musculoskeletal trauma. Inflammation resulting from trauma is considered to be the main trigger for HO by eliciting changes within the injury site, including elevation of bone morphogenetic proteins (BMPs). Recent research, however, has also associated changes in sensory neuropeptide expression with HO. Substance P (SP) and calcitonin gene-related peptide (CGRP) are two of those neuropeptides that have been implicated with various aspects of HO, including regulation of inflammation and BMP signaling...
December 11, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29222456/bmps-as-new-insulin-sensitizers-enhanced-glucose-uptake-in-mature-3t3-l1-adipocytes-via-ppar%C3%AE-and-glut4-upregulation
#18
Isabelle Schreiber, Gina Dörpholz, Claus-Eric Ott, Bjørt Kragesteen, Nancy Schanze, Cory Thomas Lee, Josef Köhrle, Stefan Mundlos, Karen Ruschke, Petra Knaus
Insulin-resistance is the main cause of type 2 diabetes. Here we describe the identification and characterization of BMP2 and BMP6 as new insulin-sensitizing growth factors in mature adipocytes. We show that BMP2 and BMP6 lead to enhanced insulin-mediated glucose uptake in both insulin-sensitive and -insensitive adipocytes. We exclude a direct effect of BMP2 or BMP6 on translocation of GLUT4 to the plasma membrane and demonstrate that these BMPs increase GLUT4 protein levels equipotent to Rosiglitazone. BMPs induce expression of PPARγ as the crucial mediator for the insulin-sensitizing effect...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29210689/an-evaluation-of-hydrologic-modeling-performance-of-epa-swmm-for-bioretention
#19
Sezar Gülbaz, Cevza Melek Kazezyılmaz-Alhan
Recent techniques should be investigated in detail to avoid present and future problems of urbanization like flood, drought and water pollution. Low Impact Development (LID) Best Management Practices (BMPs) such as bioretentions, green roofs, rain barrels, vegetative swales, and permeable pavements have been implemented to diminish the adverse effects of urbanization. In this study, a hydrological model for a Rainfall-Watershed-Bioretention (RWB) system is developed by using the Environmental Protection Agency Storm Water Management Model (EPA SWMM)...
December 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29202447/bone-forming-peptide-3-induces-osteogenic-differentiation-of-bone-marrow-stromal-cells-via-regulation-of-the-erk1-2-and-smad1-5-8-pathways
#20
Jun Sik Lee, Mi Eun Kim, Jong Keun Seon, Ju Yeon Kang, Taek Rim Yoon, Yong-Duk Park, Hyung Keun Kim
A bone-remodeling imbalance induced by increased bone resorption and osteoclast formation causes skeletal diseases such as osteoporosis. Induction of osteogenic differentiation of bone marrow stromal cells (BMSCs) leads to bone regeneration. Many researchers have tried to develop new adjuvants as specific stimulators of bone regeneration for therapeutic use in patients with bone resorption. We tried to develop a new adjuvant that has stronger osteogenic differentiation-promoting activity than bone morphogenetic proteins (BMPs)...
November 22, 2017: Stem Cell Research
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