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https://www.readbyqxmd.com/read/29771958/cooperation-of-bmp-and-ihh-signaling-in-interdigital-cell-fate-determination
#1
Arunima Murgai, Sara Altmeyer, Stephanie Wiegand, Przemko Tylzanowski, Sigmar Stricker
The elaborate anatomy of hands and feet is shaped by coordinated formation of digits and regression of the interdigital mesenchyme (IM). A failure of this process causes persistence of interdigital webbing and consequently cutaneous syndactyly. Bone morphogenetic proteins (BMPs) are key inductive factors for interdigital cell death (ICD) in vivo. NOGGIN (NOG) is a major BMP antagonist that can interfere with BMP-induced ICD when applied exogenously, but its in vivo role in this process is unknown. We investigated the physiological role of NOG in ICD and found that Noggin null mice display cutaneous syndactyly and impaired interdigital mesenchyme specification...
2018: PloS One
https://www.readbyqxmd.com/read/29766760/osteoinduction-by-ex-vivo-bone-morphogenetic-protein-gene-delivery-is-independent-of-cell-type
#2
Loek Loozen, Moyo C Kruyt, Angela Vandersteen, Angela H M Kragten, Michiel Croes, F Cumhur Oner, Jacqueline Alblas
Ex vivo non-viral gene delivery of bone-inductive factors has the potential to heal bone defects. Due to their inherent role in new bone formation, multipotent stromal cells (MSCs) have been studied as the primary target cell for gene delivery in a preclinical setting. The relative contribution of autocrine and paracrine mechanisms, and the need of osteogenic cells, remains unclear. This study investigates the contribution of MSCs as producer of transgenic BMPs and to what extent the seeded MSCs participate in actual osteogenesis...
May 16, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29753378/microrna-140-suppresses-human-chondrocytes-hypertrophy-by-targeting-smad1-and-controlling-the-bone-morphogenetic-protein-pathway-in-osteoarthritis
#3
Canfeng Li, Qinshen Hu, Zhuo Chen, Bin Shen, Jing Yang, Pengde Kang, Zongke Zhou, Fuxing Pei
BACKGROUND: This study aimed to investigate the expression levels and relationship of bone morphogenetic proteins (BMPs) signaling molecules and microRNA-140 (miR-140) in human osteoarthritis (OA) chondrocytes. MATERIALS AND METHODS: Different stage chondrocytes (normal cartilage, mid-stage OA and advanced-stage OA) were isolated from cartilage samples according to Kellgren and Lawrence criteria. The effect of miR-140 on BMPs signaling was evaluated by transfecting miR-140 mimic or inhibitor into chondrocytes...
May 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29751345/facile-fabrication-of-bowl-shaped-microparticles-for-oral-curcumin-delivery-to-ulcerative-colitis-tissue
#4
Qiubing Chen, Shuangquan Gou, Yamei Huang, Xin Zhou, Qian Li, Moon Kwon Han, Yuejun Kang, Bo Xiao
Oral microparticles (MPs) have been considered as promising drug carriers in the treatment of ulcerative colitis (UC). Here, a facile strategy based on a conventional emulsion-solvent evaporation technique was used to fabricate bowl-shaped MPs (BMPs), and these MPs loaded with anti-inflammatory drug (curcumin, CUR) during the fabrication process. The physicochemical properties of the resultant BMPs were characterized by dynamic light scattering, scanning electron microscope, confocal laser scanning microscope and X-ray diffraction as well as contact angle goniometer...
May 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29747422/role-of-bone-morphogenetic-protein-7-bmp7-in-the-modulation-of-corneal-stromal-and-epithelial-cell-functions
#5
Bhavani S Kowtharapu, Ruby Kala Prakasam, Radovan Murín, Dirk Koczan, Thomas Stahnke, Andreas Wree, Anselm G M Jünemann, Oliver Stachs
In the cornea, healing of the wounded avascular surface is an intricate process comprising the involvement of epithelial, stromal and neuronal cell interactions. These interactions result to the release of various growth factors that play prominent roles during corneal wound healing response. Bone morphogenetic proteins (BMPs) are unique multi-functional potent growth factors of the transforming growth factor-beta (TGF-β) superfamily. Treatment of corneal epithelial cells with substance P and nerve growth factor resulted to an increase in the expression of BMP7 mRNA...
May 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29746183/msx2-marks-spatially-restricted-populations-of-mesenchymal-precursors
#6
N Sakagami, Y Matsushita, S Syklawer-Howle, H M Kronenberg, W Ono, N Ono
Craniofacial development requires a set of patterning codes that define the identities of postmigratory mesenchymal cells in a region-specific manner, in which locally expressed morphogens, including fibroblast growth factors (FGFs) and bone morphogenetic proteins (BMPs), provide instructive cues. Msx2, a bona fide target of BMP signaling, is a transcription factor regulating Runx2 and osterix (Osx), whose mutations are associated with cranial deformities in humans. Here we show that Msx2 defines osteo-chondro precursor cells in specific regions of the craniofacial mesenchyme at the postmigratory stage, particularly in the mandibular process and the posterior cranial vault...
May 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29744432/bone-grafts-and-biomaterials-substitutes-for-bone-defect-repair-a-review
#7
REVIEW
Wenhao Wang, Kelvin W K Yeung
Bone grafts have been predominated used to treat bone defects, delayed union or non-union, and spinal fusion in orthopaedic clinically for a period of time, despite the emergency of synthetic bone graft substitutes. Nevertheless, the integration of allogeneic grafts and synthetic substitutes with host bone was found jeopardized in long-term follow-up studies. Hence, the enhancement of osteointegration of these grafts and substitutes with host bone is considerably important. To address this problem, addition of various growth factors, such as bone morphogenetic proteins (BMPs), parathyroid hormone (PTH) and platelet rich plasma (PRP), into structural allografts and synthetic substitutes have been considered...
December 2017: Bioactive Materials
https://www.readbyqxmd.com/read/29742172/predicting-nonpoint-stormwater-runoff-quality-from-land-use
#8
Brik R Zivkovich, David C Mays
Evaluating the impact of urban development on natural ecosystem processes has become an increasingly complex task for planners, environmental scientists, and engineers. As the built environment continues to grow, unregulated nonpoint pollutants from increased human activity and large-scale development severely stress urban streams and lakes resulting in their currently impaired or degraded state. In response, integrated water quality management programs have been adopted to address these unregulated nonpoint pollutants by utilizing best management practices (BMPs) that treat runoff as close to the source as possible...
2018: PloS One
https://www.readbyqxmd.com/read/29739878/bmpr2-inhibits-activin-and-bmp-signaling-via-wild-type-alk2
#9
Oddrun Elise Olsen, Meenu Sankar, Samah Elsaadi, Hanne Hella, Glenn Buene, Sagar Ramesh Darvekar, Kristine Misund, Takenobu Katagiri, Petra Knaus, Toril Holien
TGF-β/BMP superfamily ligands require heteromeric complexes of type 1 and 2 receptors for ligand dependent downstream signaling. Activin A, a TGF-β superfamily member, inhibits growth of multiple myeloma cells, but the mechanism is unknown. We aimed to clarify how activins affect myeloma cell survival. Activin A activates the transcription factors SMAD2/3 through the ALK4 type 1 receptor, but may also activate SMAD1/5/8 through mutated variants of the type 1 receptor ALK2. We demonstrate that activin A and B activate SMAD1/5/8 in myeloma cells through endogenous wild type ALK2...
May 8, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29719616/positive-selection-drives-the-evolution-of-endocrine-regulatory-bone-morphogenetic-protein-system-in-mammals
#10
Hafiz Ishfaq Ahmad, Muhammad Jamil Ahmad, Muhammad Muzammal Adeel, Akhtar Rasool Asif, Xiaoyong Du
The rapid evolution of reproductive proteins might be driven by positive Darwinian selection. The bone morphogenetic protein family is the largest within the transforming growth factor (TGF) superfamily. A little have been known about the molecular evolution of bone morphogenetic proteins exhibiting potential role in mammalian reproduction. In this study we investigated mammalian bone morphogenetic proteins using maximum likelihood approaches of codon substitutions to identify positive Darwinian selection in various species...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29701537/how-best-management-practices-affect-emissions-in-gas-turbine-power-plants-an-important-factor-to-consider-when-strengthening-emission-standards
#11
Jinghai Zeng, Min Xing, Min Hou, Glenn C England, Jing Yan
The Beijing Municipal Environmental Protection Bureau (EPB) is considering strengthening the Emission Standard of Air Pollutants for Stationary Gas Turbines, originally published in 2011 (DB11/847-2011), with a focus on reducing nitrogen oxides (NOx) emissions. A feasibility study was conducted to evaluate the current operation of twelve (12) existing combined-cycle gas turbine power plants and the design of two (2) new plants in Beijing and their emission reduction potential, in comparison with a state-of-the-art power plant in California, United States...
April 27, 2018: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/29695834/contribution-of-three-dimensional-architecture-and-tumor-associated-fibroblasts-to-hepcidin-regulation-in-breast-cancer
#12
Nicole Blanchette-Farra, Daniel Kita, Anna Konstorum, Lia Tesfay, David Lemler, Poornima Hegde, Kevin P Claffey, Frank M Torti, Suzy V Torti
Hepcidin is a peptide hormone that negatively regulates iron efflux and plays an important role in controlling the growth of breast tumors. In patients with breast cancer, the combined expression of hepcidin and its membrane target, ferroportin, predict disease outcome. However, mechanisms that control hepcidin expression in breast cancer cells remain largely unknown. Here, we use three-dimensional breast cancer spheroids derived from cell lines and breast cancer patients to probe mechanisms of hepcidin regulation in breast cancer...
April 26, 2018: Oncogene
https://www.readbyqxmd.com/read/29684814/transcriptional-and-translational-abundance-of-bone-morphogenetic-protein-bmp-2-4-6-7-and-their-receptors-bmpr1a-1b-and-bmpr2-in-buffalo-ovarian-follicle-and-the-role-of-bmp4-and-bmp7-on-estrogen-production-and-survival-of-cultured-granulosa-cells
#13
G Rajesh, S R Mishra, A Paul, M Punetha, G M Vidyalakshmi, K Narayanan, S Bag, S K Bhure, V Singh Chouhan, V P Maurya, G Singh, Mihir Sarkar
BMPs and their receptors modulate the granulosa cell (GC) function in the follicle of domestic animals. Since little is known on BMPs in the buffalo, the present study was aimed to investigate the expression of BMP2, 4, 6, 7 and their receptors BMPR1A, BMPR1B, BMPR2 in the GC and theca cells (TC) of ovarian follicles and the role of BMP4 and BMP7 on buffalo GC. Follicles were classified into four groups based on size and E2 level in the follicular fluid as follows: (i) Group1(4-6 mm; <0.5 ng/mL) (ii) Group 2 (7-9 mm; 0...
April 16, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29682334/factors-influencing-farmers-adoption-of-best-management-practices-a-review-and-synthesis
#14
Tingting Liu, Randall J F Bruins, Matthew T Heberling
Best management practices (BMPs) for reducing agricultural non-point source pollution are widely available. However, agriculture remains a major global contributor to degradation of waters because farmers often do not adopt BMPs. To improve water quality, it is necessary to understand the factors that influence BMP adoption by farmers. We review the findings of BMP adoption studies from both developed and developing countries, published after (or otherwise not included in) two major literature reviews from 2007 and 2008...
2018: Sustainability
https://www.readbyqxmd.com/read/29676892/multiple-pathways-to-bacterial-load-reduction-by-stormwater-best-management-practices-tradeoffs-in-performance-volume-and-treated-area
#15
Jordyn Wolfand, Colin D Bell, Alexandria B Boehm, Terri Hogue, Richard G Luthy
Stormwater best management practices (BMPs) are implemented to reduce microbial pollution in runoff, but their removal efficiencies differ. Enhanced BMPs, such as those with media amendments, can increase removal of fecal indicator bacteria (FIB) in runoff from 0.25-log10 to above 3-log10 ; however, their implications for watershed-scale management are poorly understood. In this work, a computational model was developed to simulate watershed-scale bacteria loading and BMP performance, using the Ballona Creek Watershed (Los Angeles County, CA) as a case study...
April 20, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29667526/optimizing-best-management-practices-to-control-anthropogenic-sources-of-atmospheric-phosphorus-deposition-to-inland-lakes
#16
Lee Weiss, Jesse Thé, Jennifer Winter, Bahram Gharabaghi
Excessive phosphorus loading to inland freshwater lakes around the globe has resulted in nuisance plant growth along the waterfronts, degraded habitat for cold water fisheries, and impaired beaches, marinas and waterfront property. The direct atmospheric deposition of phosphorus can be a significant contributing source to inland lakes. The atmospheric deposition monitoring program for Lake Simcoe, Ontario indicates roughly 20% of the annual total phosphorus load (2010-2014 period) is due to direct atmospheric deposition (both wet and dry deposition) on the lake...
April 18, 2018: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/29667005/the-bmp-2-mutant-l51p-a-bmp-receptor-ia-binding-deficient-inhibitor-of-noggin
#17
REVIEW
Hany Mohamed Khattab, Satoshi Kubota, Masaharu Takigawa, Takuo Kuboki, Walter Sebald
The antagonist-specific regulation in tissue engineering constitutes important attempts to achieve an improved and rapid bone regeneration by controlling the natural biological response of the natural body growth factors. L51P is molecularly engineered bone morphogentic protein-2 (BMP-2) variant with a substitution of the 51st leucine with a proline residue. L51P is deficient in BMP receptor binding, but maintains its structure and affinity for inhibitory proteins such as noggin, chordin, and gremlin. These modifications convert the BMP-2 variant L51P into a receptor-inactive inhibitor of BMP antagonists...
April 17, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29665134/the-role-of-bmp2-in-the-maturation-and-maintenance-of-the-murine-knee-joint
#18
Laura W Gamer, Steven Pregizer, Jackson Gamer, Marina Feigenson, Andreia Ionescu, Qing Li, Lin Han, Vicki Rosen
Bone morphogenetic proteins (BMPs) are key regulators of skeletal development, growth and repair. While BMP signaling is required for synovial joint formation and is also involved in preserving joint function after birth, the role of specific BMP ligands in adult joint homeostasis remains unclear. The purpose of this study was to define the role of Bmp2 in the morphogenesis and maintenance of the knee joint. To do this, we first created Bmp2-LacZ and Gdf5-LacZ knock-in mice and compared their expression patterns in the developing and postnatal murine knee joint...
April 17, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29664133/coordinated-regulation-of-the-dorsal-ventral-and-anterior-posterior-patterning-of-xenopus-embryos-by-the-btb-poz-zinc-finger-protein-zbtb14
#19
Kimiko Takebayashi-Suzuki, Hidenori Konishi, Tatsuo Miyamoto, Tomoko Nagata, Misa Uchida, Atsushi Suzuki
During early vertebrate embryogenesis, bone morphogenetic proteins (BMPs) belonging to the transforming growth factor-β (TGF-β) family of growth factors play a central role in dorsal-ventral (DV) patterning of embryos, while other growth factors such as Wnt and fibroblast growth factor (FGF) family members regulate formation of the anterior-posterior (AP) axis. Although the establishment of body plan is thought to require coordinated formation of the DV and AP axes, the mechanistic details underlying this coordination are not well understood...
April 2018: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/29660860/managing-india-s-small-landholder-farms-for-food-security-and-achieving-the-4-per-thousand-target
#20
Arun Jyoti Nath, Rattan Lal, Gudeta Weldesemayat Sileshi, Ashesh Kumar Das
The "4 per Thousand" initiative was launched at the 21st Conference of Parties (COP21) in December 2015 to address global climate change through the aspirational goal of increasing soil organic carbon (SOC) stock of the world to 40-cm depth by an average annual rate of 4%. Small landholders (SLHs), often faced with difficult bio-physical and socio-economic conditions, are the principal managers of soil in India. There are 117 million SLHs representing 85% of the total operational holdings, cultivating over 72 million ha of land, and meeting 50-60% of India's food requirement...
April 11, 2018: Science of the Total Environment
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