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https://www.readbyqxmd.com/read/28092769/spatiotemporal-change-of-phosphorous-speciation-and-concentration-in-stormwater-in-the-st-lucie-estuary-watershed-south-florida
#1
Liguang Li, Zhenli He, Zhigang Li, Suli Li, Yongshan Wan, Peter J Stoffella
Phosphorous (P) concentration in stormwater runoff varies at different spatial and temporal scales. Excessive P loading from agriculture system into the St. Lucie Estuary (SLE) contributed to water quality deterioration in southern Indian River Lagoon. This study examines the spatial and temporal shifts of different P forms in runoff and storm water under different land use, water management, and rainfall conditions. Storm water samplings were conducted monthly between April 2013 and December 2014 in typical farmland and along the waterway (Canal C-24) that connects lands to the SLE...
January 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28087075/cellular-transcriptional-response-to-zirconia-based-implant-materials
#2
Brigitte Altmann, Kerstin Rabel, Ralf J Kohal, Susanne Proksch, Pascal Tomakidi, Erik Adolfsson, Falk Bernsmann, Paola Palmero, Tobias Fürderer, Thorsten Steinberg
OBJECTIVE: To adequately address clinically important issues such as osseointegration and soft tissue integration, we screened for the direct biological cell response by culturing human osteoblasts and gingival fibroblasts on novel zirconia-based dental implant biomaterials and subjecting them to transcriptional analysis. METHODS: Biomaterials used for osteoblasts involved micro-roughened surfaces made of a new type of ceria-stabilized zirconia composite with two different topographies, zirconium dioxide, and yttria-stabilized zirconia (control)...
January 10, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28078369/effectiveness-of-integrated-best-management-practices-on-mitigation-of-atrazine-and-metolachlor-in-an-agricultural-lake-watershed
#3
Richard Lizotte, Martin Locke, Ronald Bingner, R Wade Steinriede, Sammie Smith
The study examined the influence of land-use (cropping patterns) and integrated agricultural best management practices (BMPs) on spring herbicide levels in an agricultural watershed. Atrazine and metolachlor were applied for weed control during spring of 1998-2002, 2005, and 2007-2013. Watershed-wide mass of applied herbicides ranged from 12.7 to 209.2 g atrazine and 10.9-302.2 g metolachlor with greatest application during 1998, 2009-2010 (atrazine) and 2007-2013 (metolachlor). Spring herbicide concentrations in Beasley Lake water ranged from below detection to 3...
January 11, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28075462/dnalk2-inhibits-the-proliferation-and-invasiveness-of-breast-cancer-mda-mb-231-cells-through-the-smad-dependent-pathway
#4
Ke Wang, Xiaoxiao Sun, Hong Lei Feng, Chang Fei, Yan Zhang
Breast cancer is one of the most common malignant neoplasms diagnosed in females worldwide. Bone morphogenetic proteins (BMPs), which belong to the TGF-β superfamily, regulate a wide range of cellular responses including cell proliferation, differentiation, adhesion, migration and apoptosis in breast cancer. BMPs can bind to type I and II serine/threonine kinase receptors to regulate cell proliferation, invasion, migration, and apoptosis. Type I receptors are expressed in various breast cancer cell lines and primary tumor samples...
December 30, 2016: Oncology Reports
https://www.readbyqxmd.com/read/28062564/tgf-%C3%AE-bone-morphogenetic-protein-and-activin-signaling-and-the-tumor-microenvironment
#5
Michael W Pickup, Philip Owens, Harold L Moses
The cellular and noncellular components surrounding the tumor cells influence many aspects of tumor progression. Transforming growth factor β (TGF-β), bone morphogenetic proteins (BMPs), and activins have been shown to regulate the phenotype and functions of the microenvironment and are attractive targets to attenuate protumorigenic microenvironmental changes. Given the pleiotropic nature of the cytokines involved, a full understanding of their effects on numerous cell types in many contexts is necessary for proper clinical intervention...
January 6, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28061942/a-study-on-hydrodynamic-behavior-of-fine-sediment-in-retention-structure-using-particle-image-velocimetry
#6
Masoumeh MoayeriKashani, Lai Sai Hin, Shaliza Ibrahim, Nik Meriam Nik Sulaiman
  Detention ponds are one type of stormwater best management practices (BMPs) that can be used for the quantity control of stormwater. The pond works by reducing peak discharge downstream through temporary storage and gradual release. In this paper, a new experimental procedure using particle image velocimetry (PIV) is introduced for a two-dimensional study of the hydrodynamic behavior of fine particles in a specially designed sediment basin. The hydrodynamic behavior of fine particles under different hydraulics parameters was achieved by shifting outlet placement, using different particle-size diameters, varying the distance of the inlet from the water surface, and varying the flow rate...
December 1, 2016: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/28054585/osseous-differentiation-of-human-fat-tissue-grafts-from-tissue-engineering-to-tissue-differentiation
#7
Maryna Bondarava, Chiara Cattaneo, Bin Ren, Wolfgang E Thasler, Volkmar Jansson, Peter E Müller, Oliver B Betz
Conventional bone tissue engineering approaches require isolation and in vitro propagation of autologous cells, followed by seeding on a variety of scaffolds. Those protracted procedures impede the clinical applications. Here we report the transdifferentiation of human fat tissue fragments retrieved from subcutaneous fat into tissue with bone characteristics in vitro without prior cell isolation and propagation. 3D collagen-I cultures of human fat tissue were cultivated either in growth medium or in osteogenic medium (OM) with or without addition of Bone Morphogenetic Proteins (BMPs) BMP-2, BMP-7 or BMP-9...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28041327/bone-graft-options-for-spinal-fusion-following-resection-of-spinal-column-tumors-systematic-review-and-meta-analysis
#8
Benjamin D Elder, Wataru Ishida, C Rory Goodwin, Ali Bydon, Ziya L Gokaslan, Daniel M Sciubba, Jean-Paul Wolinsky, Timothy F Witham
OBJECTIVE With the advent of new adjunctive therapy, the overall survival of patients harboring spinal column tumors has improved. However, there is limited knowledge regarding the optimal bone graft options following resection of spinal column tumors, due to their relative rarity and because fusion outcomes in this cohort are affected by various factors, such as radiation therapy (RT) and chemotherapy. Furthermore, bone graft options are often limited following tumor resection because the use of local bone grafts and bone morphogenetic proteins (BMPs) are usually avoided in light of microscopic infiltration of tumors into local bone and potential carcinogenicity of BMP...
January 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28013423/cloning-expression-profiling-and-promoter-functional-analysis-of-bone-morphogenetic-protein-6-and-7-in-tongue-sole-cynoglossus-semilaevis
#9
Qian Ma, Wenrong Feng, Zhimeng Zhuang, Shufang Liu
Bone morphogenetic proteins (BMPs) play crucial roles in vertebrate developmental process and are associated with the mechanisms which drive early skeletal development. As a first approach to elucidating the role of BMPs in regulating fish bone formation and growth, we describe the cloning, expression profiling and promoter functional analysis of bmp6 and bmp7 in tongue sole (Cynoglossus semilaevis). The full length of bmp6 and bmp7 cDNA sequences is 1939 and 1836 bp, which encodes a protein of 428 and 427 amino acids, respectively...
December 24, 2016: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28009989/overexpression-of-colorectal-cancer-oncogene-chrdl2-predicts-a-poor-prognosis
#10
Jian Sun, Xuan Liu, Hong Gao, Long Zhang, Qing Ji, Ziyuan Wang, Lihong Zhou, Yan Wang, Hua Sui, Zhongze Fan, Qi Li
Bone morphogenetic proteins (BMPs) both promote and suppress tumorigenesis, and multiple BMP antagonists reportedly contribute to cancer progression. In this study, we demonstrated that the BMP antagonist Chordin-like 2 (CHRDL2) is upregulated in colorectal cancer (CRC) tissues, and that CHRDL2 levels correlate with clinical features of CRC patients, including tumor size, TNM staging, and tumor differentiation. In addition, survival rate and Cox proportional hazards model analyses showed that high CHRDL2 levels correlate with a poor prognosis in CRC...
December 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/28008648/evaluating-the-effects-of-triclosan-on-three-field-crops-grown-in-four-formulations-of-biosolids
#11
René S Shahmohamadloo, Linda Lissemore, Ryan S Prosser, Paul K Sibley
A growing body of evidence suggests that amending soil with biosolids can be an integral component of sustainable agriculture. Despite strong evidence supporting its beneficial use in agriculture, there are concerns that chemicals, such as pharmaceuticals and personal care products (PPCPs), could present a risk to terrestrial ecosystems and human health. Triclosan (TCS) is one of the most commonly detected compounds in biosolids. To date, laboratory studies indicate that TCS likely poses a de minimis risk to field crops; however, these studies were either conducted under unrealistic exposure conditions or only assessed one or two formulations of biosolids...
December 23, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28008008/spatiotemporal-antagonism-in-mesenchymal-epithelial-signaling-in-sweat-versus-hair-fate-decision
#12
Catherine P Lu, Lisa Polak, Brice E Keyes, Elaine Fuchs
The gain of eccrine sweat glands in hairy body skin has empowered humans to run marathons and tolerate temperature extremes. Epithelial-mesenchymal cross-talk is integral to the diverse patterning of skin appendages, but the molecular events underlying their specification remain largely unknown. Using genome-wide analyses and functional studies, we show that sweat glands are specified by mesenchymal-derived bone morphogenetic proteins (BMPs) and fibroblast growth factors that signal to epithelial buds and suppress epithelial-derived sonic hedgehog (SHH) production...
December 23, 2016: Science
https://www.readbyqxmd.com/read/28005004/functional-evolution-of-a-morphogenetic-gradient
#13
Chun Wai Kwan, Jackie Gavin-Smyth, Edwin L Ferguson, Urs Schmidt-Ott
Bone Morphogenetic Proteins (BMPs) pattern the dorsal-ventral axis of bilaterian embryos; however, their roles in the evolution of body plan are largely unknown. We examined their functional evolution in fly embryos. BMP signaling specifies two extraembryonic tissues, the serosa and amnion, in basal-branching flies such as Megaselia abdita, but only one, the amnioserosa, in Drosophila melanogaster. The BMP signaling dynamics are similar in both species until the beginning of gastrulation, when BMP signaling broadens and intensifies at the edge of the germ rudiment in Megaselia, while remaining static in Drosophila...
December 22, 2016: ELife
https://www.readbyqxmd.com/read/28001443/restoring-bmprii-functions-in-pulmonary-arterial-hypertension-opportunities-challenges-and-limitations
#14
Christophe Guignabert, Sabine Bailly, Marc Humbert
Pulmonary arterial hypertension (PAH) is a cardiopulmonary disorder in which mechanical obstruction of the pulmonary vascular bed is largely responsible for the rise in pulmonary arterial pressures. The discovery of heterozygous BMPR2 germline mutations as critical predisposing factors together with a remarkable progress in our understanding of the pathogenic mechanisms have helped identify the significant and complex roles of the BMPRII axis in PAH. However, their precise contributions to the condition are still incompletely understood...
December 28, 2016: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/27982029/galnt14-promotes-lung-specific-breast-cancer-metastasis-by-modulating-self-renewal-and-interaction-with-the-lung-microenvironment
#15
Ki-Hoon Song, Mi So Park, Tulip S Nandu, Shrikanth Gadad, Sang-Cheol Kim, Mi-Young Kim
Some polypeptide N-acetyl-galactosaminyltransferases (GALNTs) are associated with cancer, but their function in organ-specific metastasis remains unclear. Here, we report that GALNT14 promotes breast cancer metastasis to the lung by enhancing the initiation of metastatic colonies as well as their subsequent growth into overt metastases. Our results suggest that GALNT14 augments the self-renewal properties of breast cancer cells (BCCs). Furthermore, GALNT14 overcomes the inhibitory effect of lung-derived bone morphogenetic proteins (BMPs) on self-renewal and therefore facilitates metastasis initiation within the lung microenvironment...
December 16, 2016: Nature Communications
https://www.readbyqxmd.com/read/27973356/towards-a-standardization-of-biomethane-potential-tests
#16
Christof Holliger, Madalena Alves, Diana Andrade, Irini Angelidaki, Sergi Astals, Urs Baier, Claire Bougrier, Pierre Buffière, Marta Carballa, Vinnie de Wilde, Florian Ebertseder, Belén Fernández, Elena Ficara, Ioannis Fotidis, Jean-Claude Frigon, Hélène Fruteau de Laclos, Dara S M Ghasimi, Gabrielle Hack, Mathias Hartel, Joern Heerenklage, Ilona Sarvari Horvath, Pavel Jenicek, Konrad Koch, Judith Krautwald, Javier Lizasoain, Jing Liu, Lona Mosberger, Mihaela Nistor, Hans Oechsner, João Vítor Oliveira, Mark Paterson, André Pauss, Sébastien Pommier, Isabella Porqueddu, Francisco Raposo, Thierry Ribeiro, Florian Rüsch Pfund, Sten Strömberg, Michel Torrijos, Miriam van Eekert, Jules van Lier, Harald Wedwitschka, Isabella Wierinck
Production of biogas from different organic materials is a most interesting source of renewable energy. The biomethane potential (BMP) of these materials has to be determined to get insight in design parameters for anaerobic digesters. Although several norms and guidelines for BMP tests exist, inter-laboratory tests regularly show high variability of BMPs for the same substrate. A workshop was held in June 2015, in Leysin, Switzerland, with over 40 attendees from 30 laboratories around the world, to agree on common solutions to the conundrum of inconsistent BMP test results...
December 2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/27965139/physiological-exercise-loading-suppresses-post-traumatic-osteoarthritis-progression-via-an-increase-in-bone-morphogenetic-proteins-expression-in-an-experimental-rat-knee-model
#17
H Iijima, A Ito, M Nagai, J Tajino, S Yamaguchi, W Kiyan, A Nakahata, J Zhang, T Wang, T Aoyama, K Nishitani, H Kuroki
OBJECTIVE: To evaluate the dose-response relationship of exercise loading in the cartilage-subchondral bone (SB) unit in surgically-induced post-traumatic osteoarthritis (PTOA) of the knee. DESIGN: Destabilized medial meniscus (DMM) surgery was performed on the right knee of 12-week-old male Wistar rats, and sham surgery was performed on the contralateral knee. Four weeks after the surgery, the animals were subjected to moderate (12 m/min) or intense (21 m/min) treadmill exercises for 30 min/day, 5 days/week for 4 weeks...
December 10, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27959431/bmp-signaling-pathways-affect-differently-migration-and-invasion-of-esophageal-squamous-cancer-cells
#18
Min Hu, Facai Cui, Fengzhen Liu, Jinlin Wang, Xiaoxia Wei, Yi Li
Bone morphogenetic proteins (BMPs) are broadly involved in normal embryo development and abnormal pathological process such as cancer. The complexity and diversity of BMPs and their signaling pathways impose quite different or even conflicting effects on clinical traits of tumors. The aim of the present study was to investigate whether different BMPs, including BMP2, BMP4, BMP6 and BMP7, influence esophageal squamous cancer cell (ESCC) growth, invasion and metastasis. BMP6 and type I receptor ALK2 and type II receptor BMPRII, ActRIIA and ActRIIB were expressed in all ESCC cell lines...
January 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/27942591/mtor-inhibition-and-bmp-signaling-act-synergistically-to-reduce-muscle-fibrosis-and-improve-myofiber-regeneration
#19
Shailesh Agarwal, David Cholok, Shawn Loder, John Li, Christopher Breuler, Michael T Chung, Hsiao Hsin Sung, Kavitha Ranganathan, Joe Habbouche, James Drake, Joshua Peterson, Caitlin Priest, Shuli Li, Yuji Mishina, Benjamin Levi
Muscle trauma is highly morbid due to intramuscular scarring, or fibrosis, and muscle atrophy. Studies have shown that bone morphogenetic proteins (BMPs) reduce muscle atrophy. However, increased BMP signaling at muscle injury sites causes heterotopic ossification, as seen in patients with fibrodysplasia ossificans progressiva (FOP), or patients with surgically placed BMP implants for bone healing. We use a genetic mouse model of hyperactive BMP signaling to show the development of intramuscular fibrosis surrounding areas of ectopic bone following muscle injury...
December 8, 2016: JCI Insight
https://www.readbyqxmd.com/read/27930933/calcitonin-induces-collagen-synthesis-and-osteoblastic-differentiation-in-human-periodontal-ligament-fibroblasts
#20
Yibo Wei, Qing Ye, Zhen Tang, Gang Tian, Qiang Zhu, Haocheng Gao, Dalin Wang, Zhizhong Cao
BACKGROUND: Extracellular matrix (ECM) secretion and osteogenic differentiation in periodontal ligament fibroblasts (PDLF) facilitate the neogenesis of alveolar bone, which is the cellular basis for alveolar bone repair. Calcitonin (CT) has been reported to play an important role in promoting ECM expression and inducing osteogenic differentiation in osteoblast, but its effects on PDLFs remain obscure. METHODS: The expression of CT, transforming growth factor-beta 1(TGF-β1) and bone morphogenetic protein (BMP) in gingival crevicular fluid (GCF) was measured by ELISA...
February 2017: Archives of Oral Biology
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