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https://www.readbyqxmd.com/read/29665682/hierarchical-fe2o3-c-mno2-c-multi-shell-nanocomposites-for-high-performance-lithium-ion-battery-and-catalyst
#1
Yu Zhang, Qing Li, Jiwei Liu, Wenbin You, Fang Fang, Min Wang, Renchao Che
The Fe2O3@C@MnO2@C (FCMC) nanocomposites containing spindle-like Fe2O3 as a core and MnO2 nanosheets as a sandwiched shell and double carbon layers have been successfully prepared by a facile method. As anode materials of lithium ion batteries (LIBs), the cycling stability, rate performance and conductivity of the prepared FCMC are far beyond that of the carbon-free Fe2O3@MnO2 (FM) nanocomposites. The hierarchical structure with double layers of carbon effectively enhances the ion conductivity and electrochemical performance of transitional metal oxides, indicating that carbon in FCMC played an important role during lithium ion storage...
April 17, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29665230/spindle-cell-rhabdomyosarcoma-of-the-anterior-mandible-manifesting-as-a-periapical-lesion-of-pulpal-origin-case-report
#2
Vanitha Sadhasivam, I Anand Sherwood, James L Gutmann, N Gururaj, V Mahalakshmi, Daffney M Doss
A 25-year-old male patient presented with swelling and pain in the mandibular anterior region for the previous 6 months. He had a history of repeated traumatic episodes associated with his lower incisors. A periapical radiograph revealed a radiolucent lesion involving the apices of the lower incisors, whereas cone beam computed tomography revealed a large osteolytic lesion involving all mandibular incisors and loss of labial and lingual cortical plates. Histological, immunohistochemical and bone scan examination of the curetted tissue established a differential diagnosis of spindle cell rhabdomyosarcoma of the anterior mandible...
April 17, 2018: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
https://www.readbyqxmd.com/read/29663703/cytological-features-of-breast-peri-implant-papillary-synovial-metaplasia
#3
José A Jiménez-Heffernan, Carmen Bárcena, Patricia Muñoz-Hernández
Synovial metaplasia is a peculiar form of metaplasia seen in the inner lining of the fibrous capsule that surrounds breast implants. Since the description of breast-implant associated anaplastic large cell lymphoma it is increasingly common to receive periprosthetic breast fluid collections for pathologic analysis. We describe a case of breast-implant papillary synovial metaplasia that showed remarkable cytologic findings. A review of the medical literature revealed one previous cytologic description. The patient, A 53-year-old woman underwent surgery because of capsular contracture of textured, silicone breast implants...
April 16, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29661912/microtubule-end-tethering-of-a-processive-kinesin-8-motor-kif18b-is-required-for-spindle-positioning
#4
Toni McHugh, Agata A Gluszek, Julie P I Welburn
Mitotic spindle positioning specifies the plane of cell division during anaphase. Spindle orientation and positioning are therefore critical to ensure symmetric division in mitosis and asymmetric division during development. The control of astral microtubule length plays an essential role in positioning the spindle. In this study, using gene knockout, we show that the kinesin-8 Kif18b controls microtubule length to center the mitotic spindle at metaphase. Using in vitro reconstitution, we reveal that Kif18b is a highly processive plus end-directed motor that uses a C-terminal nonmotor microtubule-binding region to accumulate at growing microtubule plus ends...
April 16, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29660626/tubulin-posttranslational-modifications-in-in-vitro-matured-prepubertal-and-adult-ovine-oocytes
#5
E Serra, S Succu, F Berlinguer, C Porcu, G G Leoni, S Naitana, S D Gadau
Microtubules (MTs), polymers of alpha/beta-tubulin heterodimers, are involved in crucial functions in eukaryotic cells. MTs physiology can be influenced by a variety of post-translational modifications (PTMs), including tyrosination, detyrosination, delta 2 modification, acetylation, polyglutamylation, polyglycylation. In mammalian oocytes, MTs are essential for meiosis, regulating the formation of meiotic spindle and chromosomes movements. Considering that the patterns of tubulin PTMs (tyrosination, detyrosination, acetylation, polyglutamylation and delta 2 modification) have not been investigated in ovine oocytes, this study has been designed to investigate their presence and quantification in in vitro matured (IVM) adult and prepubertal ovine oocytes...
April 7, 2018: Theriogenology
https://www.readbyqxmd.com/read/29660568/interdigitating-dendritic-cell-sarcoma-clinicopathologic-study-of-8-cases-with-review-of-the-literature
#6
REVIEW
Tian Xue, Xiang-Nan Jiang, Wei-Ge Wang, Xiao-Yan Zhou, Xiao-Qiu Li
To investigate the clinicopathologic features and differential diagnoses of interdigitating dendritic cell sarcoma (IDCS), the clinical, morphological and immunohistochemical features of eight cases of IDCS were collected and analyzed. Three patients were males and five were females, the mean age and the median age were 56.5 years and 57 years respectively. Clinically, the majority of cases involved lymph nodes. Microscopically, neoplastic cells were spindle or ovoid, forming fascicles or whorls. Every case had active mitosis figures...
March 30, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29660567/summary-of-expression-of-sparc-protein-in-cutaneous-vascular-neoplasms-and-mimickers
#7
Shakuntala H Mauzo, Denái R Milton, Victor G Prieto, Carlos A Torres-Cabala, Wei-Lien Wang, Nitin Chakravarti, Priyadharsini Nagarajan, Michael T Tetzlaff, Jonathan L Curry, Doina Ivan, Robert E Brown, Phyu P Aung
BACKGROUND: Serum protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein, which regulates cell proliferation and facilitates intracellular transport of albumin bound particles including chemotherapeutic agents such as Nab-paclitaxel/ABI-007. Therefore the presence of SPARC may achieve higher intra-tumoral drug concentration with lower dosage and thus reduce systemic side-effects. Several trials of ABI-007, in melanoma, show promising clinical activity. DESIGN: Fifty-four cases of dermal based neoplasms were retrieved including 24 angiosarcomas (AS), 10 hemangiomas, 9 nodular melanomas, 4 Kaposi sarcomas (KS), 3 leiomyosarcomas (LMS), 3 atypical fibroxanthomas (AFX) and 1 spindle cell squamous cell carcinoma (SSCC)...
March 15, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29660566/extrapleural-solitary-fibrous-tumor-a-distinct-entity-from-pleural-solitary-fibrous-tumor-an-update-on-clinical-molecular-and-diagnostic-features
#8
REVIEW
Andrea Ronchi, Immacolata Cozzolino, Federica Zito Marino, Marina Accardo, Marco Montella, Iacopo Panarese, Giuseppe Roccuzzo, Giorgio Toni, Renato Franco, Annarosaria De Chiara
Solitary fibrous tumor (SFT) is a mesenchymal neoplasm that was originally described to be localized in the pleura, but thereafter, this has been reported in several anatomic sites. Although the etiology of the neoplasm remains largely unknown, the pathogenesis seems to be related to an NAB2-STAT6 fusion gene due to paracentric inversion on chromosome 12q13. The diagnosis of extrapleural SFT is challenging, owing to its rarity, and requires an integrated approach that includes specific clinical, histological, immunohistochemical, and even molecular findings...
April 9, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29660400/hippocampal-coupling-with-cortical-and-subcortical-structures-in-the-context-of-memory-consolidation
#9
Ivan Skelin, Scott Kilianski, Bruce L McNaughton
Memory consolidation is a gradual process through which episodic memories become incorporated into long-term 'semantic' representations. It likely involves reactivation of neural activity encoding the recent experience during non-REM sleep. A critical prerequisite for memory consolidation is precise coordination of reactivation events between the hippocampus and cortical/subcortical structures, facilitated by the coupling of local field potential (LFP) oscillations (slow oscillations, sleep spindles and sharp wave/ripples) between these structures...
April 13, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29658593/laterally-spreading-features-of-gastrointestinal-stromal-tumors-a-clinicopathological-study
#10
Susumu Matsukuma, Michinori Murayama, Yoshitaka Utsumi, Koji Sumi, Kosuke Miyai, Hiroaki Takeo
To elucidate the histopathological features of laterally spreading gastrointestinal stromal tumors (GISTs), we retrospectively examined 52 GISTs grossly completely resected from 50 patients. Laterally spreading features were identified in 7 GISTs (13%), and were localized within non‑thickened regions of the muscularis propria adjacent to the main GISTs, ranging in length from 0.12 to 0.7 cm (mean, 0.3 cm). The laterally spreading features involved the muscular surgical margins in 2 cases. The morphologies of the laterally spreading cells resembled those of tumor cells in 4 cases, but were comprised of more slender spindle cells with smaller nuclei compared with those in the respective main GISTs...
April 10, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29657775/nanostructured-polyurethane-perylene-bisimide-ester-assemblies-with-tuneable-morphology-and-enhanced-stability
#11
Xiaoxiao Zhang, Tingyuan Gong, Hong Chi, Tianduo Li
Size control has been successfully achieved in inorganic materials, but it remains a challenge in polymer nanomaterials due to their polydispersity. Here, we report a facile approach to tailor the diameters of polyurethane (PU) nanoparticles (490 nm, 820 nm and 2.1 µm) via perylene bisimide (PBI) assisted self-assembly. The formed morphologies such as spindle, spherical and core-shell structures depend on the ratio of PBI and polymer concentrations. It is shown that the formation of PU nanoparticles is directed by π-π stacking of PBI and the morphology transition is not only affected by the amount of PBI incorporated, but also influenced by solvent, which controls the initial evaporation balance...
March 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29657443/healing-of-femoral-fractures-by-the-meaning-of-an-innovative-intramedullary-nail
#12
V Filardi
In this paper, an innovative design of nail, conceived to heal fractures of long bones has been investigated. Its functioning is based essentially on sliding of conical surfaces located in a spindle and in a series of holding pins radially disposed around it. Spindle and holding pins are connected together by means of a sleeve. Medial and distal screws are not necessary. Rotational and longitudinal motions of the spindle are transformed in a radial expansion of the holding pins by the sliding of conical surfaces...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29656322/p190rhogap-prevents-mitotic-spindle-fragmentation-and-is-required-to-activate-aurora-a-kinase-at-acentriolar-poles
#13
Arkadi Manukyan, Lilit Sargsyan, Sarah J Parsons, P Todd Stukenberg
Assembly of the mitotic spindle is essential for proper chromosome segregation during mitosis. Maintenance of spindle poles requires precise regulation of kinesin- and dynein-generated forces, and improper regulation of these forces disrupts pole integrity leading to pole fragmentation. The formation and function of the mitotic spindle are regulated by many proteins, including Aurora A kinase and the motor proteins Kif2a and Eg5. Here, we characterize a surprising role for the RhoA GTPase-activating protein, p190RhoGAP, in regulating the mitotic spindle...
April 14, 2018: Chromosoma
https://www.readbyqxmd.com/read/29653289/src-activation-decouples-cell-division-orientation-from-cell-geometry-in-mammalian-cells
#14
Xiaoyan Sun, Hongsheng Qi, Xiuzhen Zhang, Li Li, Jiaping Zhang, Qunli Zeng, George S Laszlo, Bo Wei, Tianhong Li, Jianxin Jiang, Alex Mogilner, Xiaobing Fu, Min Zhao
Orientation of cell division plane plays a crucial role in morphogenesis and regeneration. Misoriented cell division underlies many important diseases, such as cancer. Studies with Drosophila and C. elegance models show that Src, a proto-oncogene tyrosine-protein kinase, is a critical regulator of this aspect of mitosis. However, the role for Src in controlling cell division orientation in mammalian cells is not well understood. Using genetic and pharmacological approaches and two extracellular signals to orient cell division, we demonstrated a critical role for Src...
April 3, 2018: Biomaterials
https://www.readbyqxmd.com/read/29650917/-a-case-of-primary-spinddle-cell-carcinoma-of-the-breast
#15
Hiroshi Kawai, Chihiro Yoshikawa, Kento Kawasaki, Norichika Iga, Ryosuke Yoshida, Naohisa Waki, Futoshi Uno, Masahiro Ishizaki, Hideyuki Nishi, Kazuki Yamashita, Shinichiro Miyoshi
A 76-year-old female underwent breast-conserving surgery of the right breast and sentinel lymph node biopsy for primary breast cancer. Three years later, mammography and ultrasonography showed a small nodule in the right breast. There was nothing abnormal in the left breast. Three months later, she complained of a huge and rapid growing mass in the left breast. Malignant cells were obtained on fine needle aspiration biopsy in the right breast tumor. But it was not possible to diagnose whether the left breast tumor was benign or malignant on fine needle aspiration biopsy and needle biopsy...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650847/-a-case-of-adult-undifferentiated-sarcoma-of-the-liver-with-intraatrial-metastasis
#16
Koji Minami, Masahiko Sakoda, Satoshi Iino, Kiyokazu Hiwatashi, Kosei Maemura, Yuko Mataki, Hiroshi Kurahara, Yota Kawasaki, Yusuke Tsuruda, Tetsuro Setoyama, Hiroshi Okumura, Shigeho Maenohara, Shoji Natsugoe
A 24-year-old woman was admitted to the hospital for abdominal pain. Abdominal contrast-enhanced computed tomography( CT)revealed a cystic mass measuring 11×8 cm in the left lobe of the liver with extravasation. Vascular embolization was performed, but extravasation remained on CT images. She was then transferred to our hospital. We performed an emergency extended left hepatectomy. Histopathological examination revealed solid proliferation of spindle-shaped cells. Immunohistochemical staining showed that the tumor cells were positive for vimentin and negative for AE1/AE3...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650682/phosphoproteome-dynamics-during-mitotic-exit-in-budding-yeast
#17
Sandra A Touati, Meghna Kataria, Andrew W Jones, Ambrosius P Snijders, Frank Uhlmann
The cell division cycle culminates in mitosis when two daughter cells are born. As cyclin-dependent kinase (Cdk) activity reaches its peak, the anaphase-promoting complex/cyclosome (APC/C) is activated to trigger sister chromatid separation and mitotic spindle elongation, followed by spindle disassembly and cytokinesis. Degradation of mitotic cyclins and activation of Cdk-counteracting phosphatases are thought to cause protein dephosphorylation to control these sequential events. Here, we use budding yeast to analyze phosphorylation dynamics of 3,456 phosphosites on 1,101 proteins with high temporal resolution as cells progress synchronously through mitosis...
April 12, 2018: EMBO Journal
https://www.readbyqxmd.com/read/29650359/asymmetric-tyrosination-of-spindle-microtubules-facilitates-selfish-inheritance
#18
Shikha Laloraya
Meiotic drive is an enigmatic process that results from biased segregation of selfish genetic elements that enhance their own transmission and drive evolution. During asymmetric female meiotic divisions, selfish elements segregate preferentially towards the egg rather than polar bodies. Recent findings demonstrate that asymmetric spindle tyrosination helps selfish elements to cheat.
April 10, 2018: Trends in Cell Biology
https://www.readbyqxmd.com/read/29649038/the-effect-and-mechanism-of-millepachine-disrupted-spindle-assembly-in-tumor-cells
#19
Wenshuang Wu, Feng Liu, Anping Su, Yanping Gong, Wanjun Zhao, Yang Liu, Haoyu Ye, Jingqiang Zhu
Millepachine (MIL) is a bioactive natural product that shows great potential for cancer treatment. Previous studies showed that MIL was a novel cancer drug candidate with a special structure. To provide reference for the research and development of MIL, we further investigated the mechanism of MIL inducing G2/M arrest and found MIL disrupted spindle assembly in tumor cells. In this study, we investigated the disrupting spindle assembly effects of MIL with a focus on its potential mechanism of action. First, we indicated that MIL did not inhibit microtubule polymerization from the results of in-vivo microtubule nucleation assay and microtubule polymerization in-vitro assay but delayed this process by inhibiting the production of ATP in tumor cells...
June 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29645059/diagnosis-of-thymic-epithelial-tumor-subtypes-by-a-quantitative-proteomic-approach
#20
Ting Zhao, Jie Wu, Xiaohui Liu, Lei Zhang, Gang Chen, Haojie Lu
The histological typing of thymic epithelial tumours (TETs) still remains a challenge for surgical pathologists, especially when encountering borderline cases mainly focused on spindle cell types (including type A, atypical type A (aA), AB, and B3). A systematic proteomics analysis of TETs was performed using isobaric tags for relative and absolute quantification (iTRAQ) labeling coupled with two-dimensional liquid chromatography-tandem mass spectrometry (2D-LC-MS/MS). In total, 6479 and 6305 proteins were identified and quantified, respectively...
April 12, 2018: Analyst
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