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https://www.readbyqxmd.com/read/28528482/evertor-muscle-activity-as-a-predictor-for-recurrence-in-idiopathic-clubfoot
#1
Perajit Eamsobhana, Pipat Kongwachirapaitoon, Kamolporn Kaewpornsawan
BACKGROUND: Clubfoot is a complex three-dimensional deformity. Although brace compliance after initial correction was previously found to be significantly associated with recurrence in clubfoot, few previous studies have specifically examined evertor muscle function as a factor that contributes to recurrence in children with idiopathic and non-idiopathic clubfoot. The aim of this study was to investigate the relationship among brace compliance, evertor muscle grading, and recurrence rate in pediatric clubfoot patients...
May 20, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28522106/shorter-sleep-duration-in-early-pregnancy-is-associated-with-birth-length-a-prospective-cohort-study-in-wuhan-china
#2
Weiye Wang, Chunrong Zhong, Yu Zhang, Li Huang, Xi Chen, Xuezhen Zhou, Renjuan Chen, Xiating Li, Mei Xiao, Liping Hao, Xuefeng Yang, Nianhong Yang, Sheng Wei
OBJECTIVES: To examine the association between sleep duration in early pregnancy and fetal growth in a prospective cohort study of 3567 Chinese women. METHODS: Pregnant women at 8-16 weeks of gestation were interviewed using a semi-quantitative questionnaire to assess sleep duration. Birth weight and birth length were measured by a midwife in the delivery room at birth; low birth weight (LBW) was defined as birth weight <2500 g and small for gestational age (SGA) was defined as <10th customized centile...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28520519/oil-based-or-water-based-contrast-for-hysterosalpingography-in-infertile-women
#3
Kim Dreyer, Joukje van Rijswijk, Velja Mijatovic, Mariëtte Goddijn, Harold R Verhoeve, Ilse A J van Rooij, Annemieke Hoek, Petra Bourdrez, Annemiek W Nap, Henrike G M Rijnsaardt-Lukassen, Catharina C M Timmerman, Mesrure Kaplan, Angelo B Hooker, Anna P Gijsen, Ron van Golde, Cathelijne F van Heteren, Alexander V Sluijmer, Jan-Peter de Bruin, Jesper M J Smeenk, Jacoba A M de Boer, Eduard Scheenjes, Annette E J Duijn, Alexander Mozes, Marie J Pelinck, Maaike A F Traas, Machiel H A van Hooff, Gijsbertus A van Unnik, Cornelia H de Koning, Nan van Geloven, Jos W R Twisk, Peter G A Hompes, Ben W J Mol
Background Pregnancy rates among infertile women have been reported to increase after hysterosalpingography, but it is unclear whether the type of contrast medium used (oil-based or water-soluble contrast) influences this potential therapeutic effect. Methods We performed a multicenter, randomized trial in 27 hospitals in the Netherlands in which infertile women who were undergoing hysterosalpingography were randomly assigned to undergo this procedure with the use of oil-based or water-based contrast. Subsequently, couples received expectant management or the women underwent intrauterine insemination...
May 18, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28510215/species-specific-supercoil-dynamics-of-the-bacterial-nucleoid
#4
N Patrick Higgins
Bacteria organize DNA into self-adherent conglomerates called nucleoids that are replicated, transcribed, and partitioned within the cytoplasm during growth and cell division. Three classes of proteins help condense nucleoids: (1) DNA gyrase generates diffusible negative supercoils that help compact DNA into a dynamic interwound and multiply branched structure; (2) RNA polymerase and abundant small basic nucleoid-associated proteins (NAPs) create constrained supercoils by binding, bending, and forming cooperative protein-DNA complexes; (3) a multi-protein DNA condensin organizes chromosome structure to assist sister chromosome segregation after replication...
November 2016: Biophysical Reviews
https://www.readbyqxmd.com/read/28499768/mortality-in-people-with-psychotic-disorders-in-finland-a-population-based-13-year-follow-up-study
#5
Jaakko Keinänen, Outi Mantere, Niina Markkula, Krista Partti, Jonna Perälä, Samuli I Saarni, Tommi Härkänen, Jaana Suvisaari
OBJECTIVES: We conducted a population based study aiming at finding predictors of mortality in psychotic disorders and evaluating the extent to which sociodemographic, lifestyle and health-related factors explain the excess mortality. METHODS: In a nationally representative sample of Finns aged 30-70years (n=5642), psychotic disorders were diagnosed using structured interviews and medical records in 2000-2001. Information on mortality and causes of death was obtained of those who died by the end of year 2013...
May 9, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28498137/physical-and-organizational-job-stressors-in-pregnancy-and-associations-with-primary-cesarean-deliveries
#6
Sylvia Guendelman, Alison Gemmill, Nap Hosang, Leslie A MacDonald
OBJECTIVE: The aim of this study was to assess the relationship between exposure to physical and organizational job stressors during pregnancy and cesarean delivery. METHODS: We sampled 580 employed women in California who participated in a nested population-based case-control study of birth outcomes. Adjusted multivariate regression analyses estimated associations between heavy lifting, frequent bending, high noise, extreme temperature, prolonged standing and organizational stressors (shift work, inflexible schedules, effort-reward ratio), and primary cesarean (vs vaginal) delivery, controlling for covariates...
May 11, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28493346/no-effect-of-targeted-memory-reactivation-during-slow-wave-sleep-on-emotional-recognition-memory
#7
Jennifer E Ashton, Scott A Cairney, M Gareth Gaskell
Recent work has suggested that the benefits of sleep for memory consolidation are enhanced for highly salient (versus non-salient) memories. Using a technique known as targeted memory reactivation, it is possible to selectively strengthen newly learned memories by re-exposing the sleeping brain to auditory cues. The aim of the current study was to examine whether emotionally salient memories are also more responsive to targeted memory reactivation in slow-wave sleep than neutral memories. In an initial training phase, participants memorised emotionally negative and neutral pictures, which were each paired with a semantically related sound...
May 11, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28492508/inclusion-complexes-of-a-new-family-of-non-ionic-amphiphilic-dendrocalix-4-arene-and-poorly-water-soluble-drugs-naproxen-and-ibuprofen
#8
Khalid Khan, Syed Lal Badshah, Nasir Ahmad, Haroon Ur Rashid, Yahia Mabkhot
The inclusion complexes of a new family of nonionic amphiphilic calix[4]arenes with the anti-inflammatory hydrophobic drugs naproxen (NAP) and ibuprofen (IBP) were investigated. The effects of the alkyl chain's length and the inner core of calix[4]arenes on the interaction of the two drugs with the calix[4]arenes were explored. The inclusion complexes of Amphiphiles 1a-c with NAP and IBP increased the solubility of these drugs in aqueous media. The interaction of 1a-c with the drugs in aqueous media was investigated through fluorescence, molecular modeling, and ¹H-NMR analysis...
May 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28492190/decreased-sleep-in-children-and-their-behavioral-problems-in-dental-operatory
#9
Vinaya Kumar Kulkarni, Ami Kandya, Sakshi Arora, Garima Singh
PURPOSE: This study was conducted to examine the contribution of inadequate sleep and its associated factors, on behavior and cooperation of children in the dental operatory. MATERIALS AND METHODS: A cross-sectional study was conducted on 100 healthy children at the time of their initial visit to the dental hospital, ranging from preschoolers to adolescents. Data acquisition was done by a questionnaire. Interview with the accompanying person was done to ask about the sleep duration, naps, and sleep habits of the child...
April 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28491052/receptor-mediated-melanoma-targeting-with-radiolabeled-%C3%AE-melanocyte-stimulating-hormone-relevance-of-the-net-charge-of-the-ligand
#10
Jean-Philippe Bapst, Alex N Eberle
A majority of melanotic and amelanotic melanomas overexpress melanocortin type 1 receptors (MC1Rs) for α-melanocyte-stimulating hormone. Radiolabeled linear or cyclic analogs of α-MSH have a great potential as diagnostic or therapeutic tools for the management of malignant melanoma. Compounds such as [(111)In]DOTA-NAP-amide exhibit high affinity for the MC1R in vitro, good tumor uptake in vivo, but they may suffer from relatively high kidney uptake and retention in vivo. We have shown previously that the introduction of negative charges into radiolabeled DOTA-NAP-amide peptide analogs may enhance their excretion and reduce kidney retention...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28488939/differences-in-morning-evening-type-and-sleep-duration-between-black-and-white-adults-results-from-a-propensity-matched-uk-biobank-sample
#11
Susan Kohl Malone, Freda Patterson, Alicia Lozano, Alexandra Hanlon
Biological evidence suggests that ethno-racial differences in morning-evening type are possible, whereby Blacks may be more likely to be morning type compared to Whites. However, population-level evidence of ethno-racial difference in morning-evening type is limited. In an earlier study, we reported that morning type was more prevalent in Blacks compared to Whites in the United Kingdom (UK) Biobank cohort (N = 439 933). This study aimed to determine if these ethno-racial differences persisted after accounting for an even broader range of social, environmental and individual characteristics and employing an analytic approach that simulates randomization in observational data, propensity score modeling...
May 10, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28482570/heteroleptic-silver-i-complexes-with-2-2-6-2%C3%A2-terpyridines-and-naproxen-dna-interaction-egfr-vegfr2-kinase-growth-inhibition-and-cell-cycle-arrest-studies
#12
Dharmasivam Mahendiran, Raju Senthil Kumar, Aziz Kalilur Rahiman
A series of heteroleptic silver(I) complexes of the type [Ag(L(1-3))(nap)] (1-3), where L(1-3)=4'-(4-substituted)-2,2':6',2″-terpyridines and nap=naproxen have been synthesized and characterized by elemental analysis and spectroscopic methods. The geometric parameters of the complexes were determined using UV-Vis and DFT calculations together with the IR spectral data. All the complexes adopted distorted tetrahedral geometry around silver(I) ion. The small HOMO-LUMO energy gap supports the bioefficacy of the complexes...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28482100/apoe-genotype-and-non-respiratory-sleep-parameters-in-cognitively-intact-older-adults
#13
Adam P Spira, Yang An, Yu Peng, Mark N Wu, Eleanor M Simonsick, Luigi Ferrucci, Susan M Resnick
Study Objectives: The apolipoprotein E (APOE) Ɛ4 allele increases Alzheimer's disease (AD) risk and has been linked to a greater risk of sleep-disordered breathing. We investigated the association of APOE genotype with non-respiratory sleep parameters. Methods: We studied 1,264 cognitively normal participants in the Baltimore Longitudinal Study of Aging (mean = 57.5±16.1 years, range 19.9-92.0, 48.2% women, 19.8% African American) with APOE genotyping and self-reported sleep duration (≥9, 7 or 8, ≤6 hours), difficulty falling/staying asleep, and napping...
May 6, 2017: Sleep
https://www.readbyqxmd.com/read/28481474/instant-hydrogelation-inspired-by-inflammasomes
#14
Huaimin Wang, Zhaoqianqi Feng, Alvin Lu, Yujie Jiang, Hao Wu, Bing Xu
Based on the recent structures of the PYRIN domain of ASC in the protein filament of inflammasomes and the observation that pyridoxal phosphate (P5P) modulates the self-assembly of ASC, we rationally designed an N-terminal capped nonapeptide (Nap-FFKKFKLKL, 1) to form supramolecular nanofibers consisting of α-helix. The addition of P5P to the solution of 1 results in a hydrogel almost instantly (about 4 seconds). Several other endogenous small molecules (e.g., pyridoxal, folinic acid, ATP, and AMP) also convert the solution of 1 to a hydrogel...
May 8, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28476339/sleep-quality-is-associated-with-weight-loss-maintenance-status-the-medweight-study
#15
M Yannakoulia, C A Anastasiou, E Karfopoulou, A Pehlivanidis, D B Panagiotakos, A Vgontzas
Sleep duration and quality have been associated with many health outcomes, including weight management. We aimed to investigate the effect of self-reported sleep duration and quality on weight loss maintenance in participants of the MedWeight study, a registry of individuals that lost at least 10% of body weight in the past and either maintained the loss (maintainers: weight maintenance of at least 10% of initial weight loss) or regained it (regainers: weight ≥95% of their maximum body weight). Study participants included 528 volunteers (61% women)...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28475689/intermediate-but-not-extended-afternoon-naps-may-preserve-cognition-in-chinese-older-adults
#16
Junxin Li, Yu-Ping Chang, Barbara Riegel, Brendan T Keenan, Miranda Varrasse, Allan I Pack, Nalaka S Gooneratne
Background: The association between daytime napping and cognition is not well-studied in older adults. This study aimed to examine the associations between self-reported afternoon nap duration and change in cognition after 2-year follow-up in Chinese older adults. Methods: A total of 3,037 individuals aged 60 years and older from the China Health and Retirement Longitudinal Study baseline and 2-year follow-up were included. Overall cognition was assessed by three interview-based sub-measures of orientation to time and attention, episodic memory, and visuospatial abilities...
May 5, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28471950/comparison-of-sleep-latency-and-number-of-soremps-in-the-home-and-hospital-with-a-modified-multiple-sleep-latency-test-a-randomized-crossover-study
#17
Kornelia K Beiske, Trond Sand, Eyvind Rugland, Knut Stavem
PURPOSE: Comparison of mean sleep latencies and number of sleep-onset rapid eye movement periods (SOREMPs) between modified multiple sleep latency test (MSLT) performed in the unattended home and in-hospital laboratory setting. METHODS: A randomized crossover single-blinded design. Thirty-four subjects referred to MSLT for suspected hypersomnia or narcolepsy were included. Participants were randomized to perform modified MSLT in the unattended home or in the hospital first...
May 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/28471526/preterm-infants-at-discharge-nap-polysomnography-versus-24-hour-oximetry
#18
Tamsin Roberts, Angela Campbell, Peter Larsen, Dawn Elder
AIM: This study aimed to determine whether measures of intermittent hypoxia derived from 24-hour oximetry correlate with measures of apnoea derived from modified nap polysomnography undertaken for preterm infants before discharge. METHODS: Infants born ≤32 weeks gestation were recruited from the Neonatal Intensive Care Unit, and had a modified polysomnography to assess their respiratory stability once they were ≥35 weeks postmenstrual age. Infants were defined as unstable if they had more than 10 obstructive events per hour or any apnoea of > 20 seconds in length...
May 4, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28470854/cardiac-autonomic-activity-during-daytime-nap-in-young-adults
#19
Nicola Cellini, Jacopo Torre, Luciano Stegagno, Michela Sarlo
The current study investigated both sympathetic and vagal autonomic patterns during a daytime sleep in 25 healthy adults (23.2 ± 2.4 years). Pre-ejection period (PEP; related inversely to beta-adrenergic sympathetic activity), the interval between consecutive R-waves (RR) and frequency-domain heart rate variability (HRV) were computed during pre-nap wakefulness and undisturbed sleep stages. Results showed sleep-related changes in RR and HRV measures, whereas PEP decreased significantly from pre-nap to sleep, showing no differences across sleep stages...
May 4, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28468061/-distributions-and-associations-between-duration-of-sleep-daytime-naps-and-insomnia-symptoms-among-chinese-adults
#20
B Zheng, L L Lin, C Q Yu, J Lyu, Y Guo, Z Bian, Y L Tan, P Pei, J S Chen, Z M Chen, L M Li
Objective: To investigate the distribution of sleep duration, daytime naps habits, and insomnia-related symptoms among participants from the China Kadoorie Biobank (CKB) study, and to examine the associations between the sleep-associated factors. Methods: A self-designed computer-based questionnaire was adopted to collect social-demographic information and lifestyle-related factors of the participants. A total of 452 829 Chinese adults aged 30-79 years, without self-reported histories of coronary heart disease, stroke, chronic obstructive pulmonary diseases or cancer, were included in this study...
April 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
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