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https://www.readbyqxmd.com/read/28652569/characterization-of-a-novel-two-component-na-li-k-h-antiporter-from-halomonas-zhaodongensis
#1
Lin Meng, Fankui Meng, Rui Zhang, Zhenglai Zhang, Ping Dong, Kaifu Sun, Jin Chen, Wei Zhang, Mingxue Yan, Jincheng Li, Heba Abdel-Motaal, Juquan Jiang
In this study, genomic DNA was screened for novel Na(+)/H(+) antiporter genes from Halomonas zhaodongensis by selection in Escherichia coli KNabc lacking three major Na(+)/H(+) antiporters. Co-expression of two genes designated umpAB, encoding paired homologous unknown membrane proteins belonging to DUF1538 (domain of unknown function with No. 1538) family, were found to confer E. coli KNabc the tolerance to 0.4 M NaCl and 30 mM LiCl, and an alkaline pH resistance at 8.0. Western blot and co-immunoprecipitation establish that UmpAB localize as a hetero-dimer in the cytoplasmic membranes...
June 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28650023/ligand-induced-conformational-preorganization-of-loops-of-c-myc-g-quadruplex-dna-and-its-implications-in-structure-specific-drug-design
#2
S Harikrishna, Saikiran Kotaru, P I Pradeepkumar
Stabilization of a G-quadruplex (G4) DNA structure in the proto-oncogene c-MYC using small molecule ligands has emerged as an attractive strategy for the development of anticancer therapeutics. To understand the subtle structural changes in the G4 structure upon ligand binding, molecular dynamics (MD) simulations of c-MYC G4 DNA were carried out in a complex with six different potent ligands: 3AQN, 6AQN, 3APN, 360A, Nap-Et, and Nap-Pr. The results show that the ligands 3AQN, 6AQN, 3APN, and 360A stabilize the G4 structure by making stacking interactions with the top quartet...
June 26, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28649124/a-modified-bowel-preparation-regimen-for-colonoscopy-providing-the-patients-satisfaction-and-convenience
#3
Chia-Cheng Wen, Shu-Wen Jao, Cheng-Wen Hsiao
BACKGROUND A complete cleansing of the bowel is a critical factor that impacts the diagnostic accuracy of colonoscopies. However, the common bowel preparation regimen of two 45 mL doses of sodium phosphate (2×NaP) often leads to uncomfortable symptoms and subsequently lower patient adherence. To improve patient adherence and satisfaction, we proposed a modified regimen composed of two sennoside tablets and one bottle of NaP (S+NaP) and we then evaluated bowel preparation quality and patient satisfaction. MATERIAL AND METHODS A total of 531 patients who underwent colonoscopies at the outpatient coloproctology clinic from January 2016 to December 2016 were retrospectively reviewed...
June 26, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28645479/impact-of-the-nap-1-strain-on-disease-severity-mortality-and-recurrence-of-healthcare-associated-clostridium-difficile-infection
#4
Karri A Bauer, Jessica E W Johnston, Eric Wenzler, Debra A Goff, Charles H Cook, Joan-Miquel Balada-Llasat, Preeti Pancholi, Julie E Mangino
OBJECTIVES: Studies are conflicting regarding the association of the North American pulsed-field gel electrophoresis type 1 (NAP1) strain in Clostridium difficile infection (CDI) and outcomes. We evaluated the association of NAP1 with healthcare-associated CDI disease severity, mortality, and recurrence at our academic medical center. METHODS: Healthcare-associated CDI cases were identified from November 1, 2011 through January 31, 2013. Multivariable regression models were used to evaluate the associations of NAP1 with severe disease (based on the Hines VA severity score index), mortality, and recurrence...
June 20, 2017: Anaerobe
https://www.readbyqxmd.com/read/28637840/promoting-sleep-oscillations-and-their-functional-coupling-by-transcranial-stimulation-enhances-memory-consolidation-in-mild-cognitive-impairment
#5
Julia Ladenbauer, Josef Ladenbauer, Nadine Külzow, Rebecca de Boor, Elena Avramova, Ulrike Grittner, Agnes Flöel
Alzheimer's disease (AD) not only involves loss of memory functions but also prominent deterioration of sleep physiology, already evident in the stage of mild cognitive impairment (MCI). Cortical slow oscillations (SO, 0.5-1 Hz) and thalamo-cortical spindle activity (12-15 Hz) during sleep, and their temporal coordination, are considered critical for memory formation. We investigated the potential of slow oscillatory transcranial direct current stimulation (so-tDCS), applied during a daytime nap in a sleep state-dependent manner, to modulate these activity patterns and sleep-related memory consolidation in 9 male and 7 female human patients with MCI...
June 21, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28636622/inhibition-of-hepatitis-b-viral-entry-by-nucleic-acid-polymers-in-heparg-cells-and-primary-human-hepatocytes
#6
Clément Guillot, Nora Martel, Françoise Berby, Isabelle Bordes, Olivier Hantz, Matthieu Blanchet, Camille Sureau, Andrew Vaillant, Isabelle Chemin
Hepatitis B virus (HBV) infection remains a major public health concern worldwide with 240 million individuals chronically infected and at risk of developing cirrhosis and hepatocellular carcinoma. Current treatments rarely cure chronic hepatitis B infection, highlighting the need for new anti-HBV drugs. Nucleic acid polymers (NAPs) are phosphorothioated oligonucleotides that have demonstrated a great potential to inhibit infection with several viruses. In chronically infected human patients, NAPs administration lead to a decline of blood HBsAg and HBV DNA and to HBsAg seroconversion, the expected signs of functional cure...
2017: PloS One
https://www.readbyqxmd.com/read/28636534/novel-tropolones-induce-the-unfolded-protein-response-pathway-and-apoptosis-in-multiple-myeloma-cells
#7
Staci L Haney, Cheryl Allen, Michelle L Varney, Kaitlyn M Dykstra, Eric R Falcone, Sean H Colligan, Qiang Hu, Alyssa M Aldridge, Dennis L Wright, Andrew J Wiemer, Sarah A Holstein
Tropolones are small organic compounds with metal-directing moieties. Tropolones inhibit the proliferation of cancer cell lines, possibly through their effects on metalloenzymes such as select histone deacetylases (HDACs). Pan-HDAC inhibitors are therapeutically beneficial in the treatment of multiple myeloma, however there is interest in the use of more selective HDAC inhibitor therapy to minimize adverse side effects. We hypothesized that tropolones might have anti-myeloma activities. To this end, a series of novel α-substituted tropolones were evaluated for effects on multiple myeloma cells...
June 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28632088/the-association-of-daytime-maternal-napping-and-exercise-with-nighttime-sleep-in-first-time-mothers-between-3-and-6-months-postpartum
#8
Teresa A Lillis, Nancy A Hamilton, Sarah D Pressman, Christina S Khou
OBJECTIVE: This study investigated the relationship of daytime maternal napping, exercise, caffeine, and alcohol intake to objective and subjective sleep indices. PARTICIPANTS: Sixty healthy, nondepressed, first-time mothers between 3 and 6 months postpartum. METHODS: Seven consecutive days of online behavior diaries, sleep diaries, and wrist actigraphy, collecting Total Sleep Time (TST), Sleep Onset Latency (SOL), and Wake After Sleep Onset (WASO)...
October 19, 2016: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/28627868/alkaline-phosphatase-instructed-self-assembly-of-gadolinium-nanofibers-for-enhanced-t2-weighted-magnetic-resonance-imaging-of-tumor
#9
Ling Dong, Junchao Qian, Zijuan Hai, Jinyong Xu, Wei Du, Kai Zhong, Gaolin Liang
Alkaline phosphatase (ALP) is an important enzyme but using ALP-instructed self-assembly of gadolinium nanofibers for enhanced T2-weighted magnetic resonance imaging (MRI) of tumor has not been reported. In this work, we rationally designed a hydrogelator Nap-FFFYp-EDA-DOTA(Gd) (1P) which, under the catalysis of ALP, was able to self-assemble into gadolinium nanofibers to form hydrogel Gel I for enhanced T2-weighted MR imaging of ALP activity in vitro and in tumor. T2 phantom MR imaging indicated that the transverse relaxivity (r2) value of Gel I was 33...
June 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28625964/antegrade-dissection-and-reentry-as-part-of-the-hybrid-chronic-total-occlusion-revascularization-strategy-a-subanalysis-of-the-recharge-registry-registry-of-crossboss-and-hybrid-procedures-in-france-the-netherlands-belgium-and-united-kingdom
#10
Joren Maeremans, Jo Dens, James C Spratt, Alan J Bagnall, Wynand Stuijfzand, Alexander Nap, Pierfrancesco Agostoni, William Wilson, Colm G Hanratty, Simon Wilson, Benjamin Faurie, Alexandre Avran, Erwan Bressollette, Mohaned Egred, Paul Knaapen, Simon Walsh
BACKGROUND: Development of the CrossBoss and Stingray devices for antegrade dissection and reentry (ADR) of chronic total occlusions has improved historically suboptimal outcomes. However, the outcomes, safety, and failure modes of the technique have to be studied in a larger patient cohort. This preplanned substudy of the RECHARGE registry (Registry of CrossBoss and Hybrid Procedures in France, the Netherlands, Belgium and United Kingdom) aims to evaluate the value and use of ADR and determine its future position in contemporary chronic total occlusion intervention...
June 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28625940/prodromal-stage-of-disease-dementia-with-lewy-bodies-how-to-diagnose-in-practice
#11
Frédéric Blanc, Marc Verny
Disease with Lewy bodies or dementia with Lewy bodies (DLB), particularly at the prodromal stage, is a complex disease to diagnose because of different clinical beginnings and variable paths in terms of clinical expression. Thus DLB can be entcountered in different input modes: mild cognitive impairment, depression, acute behavioral disorders, confusion and delirium, or sleep disorders. In the aim to better diagnose the disease, should be sought obviously to search for the key symptoms: fluctuations, hallucinations, extra-pyramidal syndrome, and REM sleep behavior disorder...
June 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/28622637/children-benefit-differently-from-night-and-day-time-sleep-in-motor-learning
#12
Jin H Yan
Motor skill acquisition occurs while practicing (on-line) and when asleep or awake (off-line). However, developmental questions still remain about whether children of various ages benefit similarly or differentially from night- and day-time sleeping. The likely circadian effects (time-of-day) and the possible between-test-interference (order effects) associated with children's off-line motor learning are currently unknown. Therefore, this study examines the contributions of over-night sleeping and mid-day napping to procedural skill learning...
June 13, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28621386/functionalization-of-graphene-oxide-with-9-aminoanthracene-for-the-adsorptive-removal-of-persistent-aromatic-pollutants-from-aqueous-solution
#13
Ali Balati, Mohammad Ghanbari, Karimi Behzad, M Mostafa Amini
A novel modified graphene oxide nanocomposite was fabricated via a facial procedure, aiming to removal of the aromatic pollutants from aqueous solution. The graphene oxide (GO) was functionalized with 9-aminoanthracene and produced graphene oxide-9-aminoanthracene (GO-9-AA). FTIR, XRD, TGA, TEM and Raman spectroscopy techniques were used for characterization of the adsorbents. Adsorption of naphthalene (NAP), acenaphthylene (ACN), and phenanthrene (PHN) as a model of polycyclic aromatic hydrocarbons (PAHs) was investigated by GO-9-AA...
June 2017: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/28618358/identifying-structural-characteristics-of-humic-acid-to-static-and-dynamic-fluorescence-quenching-of-phenanthrene-9-phenanthrol-and-naphthalene
#14
Lin Wang, Hao Li, Yu Yang, Di Zhang, Min Wu, Bo Pan, Baoshan Xing
Fluorescence quenching is a sensitive and fast method to quantify the interactions between a fluorescent organic contaminant and a quencher, such as dissolved organic matter (DOM). Dynamic fluorescence quenching is resulted from molecular collision, not the real binding, and thus it complicates the binding data interpretation. On the other hand, static fluorescence quenching occurs for fluorescent contaminants of ground states, which decreases the concentration of freely dissolved contaminants. However, how a particular structure in DOM contributes to the static and dynamic fluorescence quenching of a fluorescent contaminant is still unclear, which has greatly hindered the application of fluorescence quenching technique...
June 12, 2017: Water Research
https://www.readbyqxmd.com/read/28617306/characterization-of-hemagglutinin-negative-botulinum-progenitor-toxins
#15
Suzanne R Kalb, Jakub Baudys, Theresa J Smith, Leonard A Smith, John R Barr
Botulism is a disease involving intoxication with botulinum neurotoxins (BoNTs), toxic proteins produced by Clostridium botulinum and other clostridia. The 150 kDa neurotoxin is produced in conjunction with other proteins to form the botulinum progenitor toxin complex (PTC), alternating in size from 300 kDa to 500 kDa. These progenitor complexes can be classified into hemagglutinin positive or hemagglutinin negative, depending on the ability of some of the neurotoxin-associated proteins (NAPs) to cause hemagglutination...
June 15, 2017: Toxins
https://www.readbyqxmd.com/read/28616739/petrol-filling-workers-as-biomonitor-of-pah-exposure-and-functional-health-capacity-in-resource-limited-settings-of-city-rawalpindi-pakistan
#16
Audil Rashid, Shu Taov, Ikhtiar Uddin, Atif Kamal
This is the first study from Pakistan to report the exposure of petrol filling workers (n = 120) to naphthalene (Nap) and pyrene (Pyr) in relation to their functional capacities and health outcome. A group of non-exposed subjects (controls n = 46) was also recruited for comparison. The perceived health risk of the exposed workers was monitored using a questionnaire based on the self-reporting survey. The observed physical anomalies related to the health disorder included the acidity after meals, eye redness, appetite loss, skin lesions, and dryness of oral cavity, while those related to neurasthenic symptoms included the body aches, energy loss, twitching, fatigue, sleeplessness, fainting, and irritability...
June 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28614928/-analysis-of-inner-or-extra-exposure-for-worker-in-carbon-and-coal-tar-process-industries
#17
X C Wang, F Zhang, N Jia, W Zhang, X Y Zhang, J Li, H Shao
Objective: To evaluate the inner or extra-exposure of workers in carbon and coal tar process industries. Methods: In May 2015, 271 exposure and 75 non-exposure workers in two of carbon and coal tar process industries in Shandong province were selected. Coal tar pitch (CTP) was detected according to the methods of GB17054-1997. The 1-OH-Nap、2-OH-Nap、1-OH-Pyr in urine were detected by high performance liquid Chromatography (HPLC) . Results: The concentration of 1-OH-Nap、2-OH-Nap、1-OH-Pyr in urine of exposure group were significant higher than that of control group (P<0...
April 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28614924/-effects-of-smoking-on-concentration-of-urinary-8-hydroxydeoxyguanosine-in-coke-oven-workers
#18
H J Zhang, H T Zhang, W B Wang, Y F Fan, J Yang
Objective: To explore the influence of smoking and polycyclic aromatic hydrocarbons (PAHs) on urinary 8-hydroxydeoxyguanosine (8-OHdG) in coke oven workers and investigate their dose-dependent relationships. Methods: A total of 436 workers exposed to coke oven emissions (COEs) and 132 controls were recruited in this study. Questionnaires were completed in a personal interview. Then their urine samples were also collected and the concentrations of urinary four OH-PAHs and 8-OHdG were determined by high performance liquid chromatography (HPLC) which was used to evaluate the levels of occupational PAHs internal exposure among workers and the DNA damage...
April 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28612266/daytime-napping-and-risk-of-type-2-diabetes-a-meta-analysis-of-prospective-studies
#19
Guo-Chong Chen, Meng-Meng Liu, Li-Hua Chen, Jia-Ying Xu, Khemayanto Hidayat, Fu-Rong Li, Li-Qiang Qin
PURPOSE: Prospective studies reported inconsistent findings on the relationship between daytime napping and risk of type 2 diabetes (T2D). Categorized and dose-response meta-analyses were performed to quantify this relation. METHODS: Potentially eligible studies were identified by searching PubMed and Embase databases. Dose-response effects were assessed by the generalized least squares trend estimation and study-specific summary relative risks (RRs) with 95% confidence intervals (CIs) were computed with a random-effects model...
June 13, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28608279/the-recombinant-fusion-protein-of-cholera-toxin-b-and-neutrophil-activating-protein-expressed-on-bacillus-subtilis-spore-surface-suppresses-allergic-inflammation-in-mice
#20
Hui Dong, Yanmei Huang, Shuwen Yao, Bingshao Liang, Yan Long, Yongqiang Xie, Jialiang Mai, Sitang Gong, Zhenwen Zhou
The neutrophil-activating protein of Helicobacter pylori (HP-NAP) has been identified as a modulator with anti-Th2 inflammation activity, and cholera toxin B (CTB) is a mucosal adjuvant that can also induce antigen tolerance. In this study, we constructed a CTB-NAP fusion protein on the surface of Bacillus subtilis spore and evaluate the efficiency of oral administration of the recombinant CTB-NAP spores in preventing asthma in mice. Oral administration of recombinant CTB or CTB-NAP spores significantly decreased serum ovalbumin (OVA)-specific IgE (p < 0...
June 12, 2017: Applied Microbiology and Biotechnology
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