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https://www.readbyqxmd.com/read/29241109/pharmacokinetic-studies-of-naproxen-amides-of-some-amino-acid-esters-with-promising-colorectal-cancer-chemopreventive-activity
#1
Tarek Aboul-Fadl, Soliman S Al-Hamad, Ehab A Fouad
Naproxen (nap) is belonging to Non-steriodal anti-inflammatory drugs (NSAIDs) group of drugs that characterized by their free carboxylic group. The therapeutic activity of nap is usually accompanied by GI untoward side effects. Recently synthesized naproxen amides of some amino acid esters prodrugs to mask the free carboxylic group were reported. Those prodrugs showed a promising colorectal cancer chemopreventive activity. The current study aims to investigate the fate and hydrolysis of the prodrugs kinetically in different pH conditions, simulated gastric and intestinal fluids with pHs of 1...
December 2, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29238417/the-effect-of-music-intervention-on-dental-anxiety-during-dental-extraction-procedure
#2
Tantry Maulina, Nina Djustiana, M Nurhalim Shahib
Background: In order to minimize the possibility of unsuccessful dental extraction procedure due to dental anxiety, there are several approaches that can be used, including music intervention. Objective: The objective of this research was to investigate the effectiveness of classical and religious Islamic music on reducing dental anxiety. Materials and methods: Two hundred and twenty-five muslim participants (105 males, 120 females) were recruited for this study and randomly assigned to three groups: classical music group, religious Islamic music group, and the group with no music intervention, equally in numbers...
2017: Open Dentistry Journal
https://www.readbyqxmd.com/read/29236563/feasibility-of-a-modified-ride-on-car-intervention-on-play-behaviors-during-an-inclusive-playgroup
#3
Samantha Mae Ross, Michele Catena, Erica Twardzik, Christina Hospodar, Erika Cook, Apoorva Ayyagari, Kelsey Inskeep, Bethany Sloane, Megan M MacDonald, Samuel W Logan
AIMS: Children with mobility related disabilities often experience limited participation and access to social interactions. An emerging pediatric powered mobility device are modified ride-on cars that provide self-directed mobility experiences to children with disabilities. This study aimed to determine: (1) the feasibility of a modified ride-on car intervention during an inclusive playgroup, (2) the effect of a modified ride-on car intervention on the play behaviors of children with and without mobility related disabilities...
December 13, 2017: Physical & Occupational Therapy in Pediatrics
https://www.readbyqxmd.com/read/29235601/ruthenium-ii-arene-nsaid-complexes-inhibition-of-cyclooxygenase-and-antiproliferative-activity-against-cancer-cell-lines
#4
Poulami Mandal, Bidyut Kumar Kundu, Komal Vyas, Vidya Sabu, A Helen, Sandeep Singh Dhankhar, C M Nagaraja, Debojit Bhattacherjee, Krishna Pada Bhabak, Suman Mukhopadhyay
Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of molecules which have been found to be active against cancer cells with chemopreventive properties by targeting cyclooxygenase (COX-1 and COX-2) and lipoxygenase (LOX), commonly upregulated (particularly COX-2) in malignant tumors. Arene ruthenium(ii) complexes with a pseudo-octahedral coordination environment containing different ancillary ligands have shown remarkable activity against primary and metastatic tumors as reported earlier. This work describes the synthesis of four novel ruthenium(ii)-arene complexes viz...
December 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29232224/analgesic-somnoform-in-waterbury-nap-a-minit-adds-chlorides-to-the-bromide
#5
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Anesthesiology
https://www.readbyqxmd.com/read/29230970/the-dnabii-family-of-proteins-is-comprised-of-the-only-nucleoid-associated-proteins-required-for-nontypeable-haemophilus-influenzae-biofilm-structure
#6
Aishwarya Devaraj, John Buzzo, Christopher J Rocco, Lauren O Bakaletz, Steven D Goodman
Biofilms play a central role in the pathobiology of otitis media (OM), bronchitis, sinusitis, conjunctivitis, and pneumonia caused by nontypeable Haemophilus influenzae (NTHI). Our previous studies show that extracellular DNA (eDNA) and DNABII proteins are essential components of biofilms formed by NTHI. The DNABII protein family includes integration host factor (IHF) and the histone-like protein HU and plays a central role in NTHI biofilm structural integrity. We demonstrated that immunological targeting of these proteins during NTHI-induced experimental OM in a chinchilla model caused rapid clearance of biofilms from the middle ear...
December 12, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/29230867/sleep-patterns-and-problems-in-infants-and-young-children-in-ireland
#7
S Hanafin
BACKGROUND: There is an increasing recognition that sleep is an important aspect of health and well-being, and this is particularly the case in infancy and early childhood where sleep behaviours and patterns can result in substantial problems. METHODS: This paper draws on Wave 1, 2, and 3 data from Growing Up in Ireland, the national longitudinal study of children in Ireland to provide an overview of sleep patterns in a population of children aged 9 months (n = 11,112), 3 years (n = 9,790), and 5 years (n = 8,996)...
December 12, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/29224300/-etiological-analysis-and-establishment-of-a-discriminant-model-for-lower-respiratory-tract-infections-in-hospitalized-patients
#8
Y S Chen, X H Lin, H R Li, Z D Hua, M Q Lin, W S Huang, T Yu, H Y Lyu, W P Mao, Y Q Liang, X R Peng, S J Chen, H Zheng, S Q Lian, X L Hu, X Q Yao
Objective: To analyze the pathogens of lower respiratory tract infection(LRTI) including bacterial, viral and mixed infection, and to establish a discriminant model based on clinical features in order to predict the pathogens. Methods: A total of 243 hospitalized patients with lower respiratory tract infections were enrolled in Fujian Provincial Hospital from April 2012 to September 2015. The clinical data and airway (sputum and/or bronchoalveolar lavage) samples were collected. Microbes were identified by traditional culture (for bacteria), loop-mediated isothermal amplification(LAMP) and gene sequencing (for bacteria and atypical pathogen), or Real-time quantitative polymerase chain reaction (Real-time PCR)for viruses...
December 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29223777/child-care-centre-adherence-to-infant-physical-activity-and-screen-time-recommendations-in-australia-canada-and-the-united-states-an-observational-study
#9
Lyndel Hewitt, Sara E Benjamin-Neelon, Valerie Carson, Rebecca M Stanley, Ian Janssen, Anthony D Okely
OBJECTIVE: The aim of this study was to compare adherence to physical activity and sedentary behaviour recommendations within the 2011 Institute of Medicine Early Childhood Obesity Prevention Policies as well as screen time recommendations from the 2013 American Academy of Pediatrics for samples of infants in child care centres in Australia, Canada, and the United States (US). METHODS: This cross-sectional study used data from: the Australian 2013 Standing Preschools (N=9) and the 2014-2017 Early Start Baseline (N=22) studies; the 2011 Canadian Healthy Living Habits in Pre-School Children study (N=14); and the American 2008 (N=31) and 2013-2017 (N=31) Baby Nutrition and Physical Activity Self-Assessment for Child Care (NAP SACC) trials...
December 7, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/29221783/the-effect-of-sleep-duration-and-sleep-quality-on-hypertension-in-middle-aged-and-older-chinese-the-dongfeng-tongji-cohort-study
#10
Dongming Wang, Yun Zhou, Yanjun Guo, Runbo Zhang, Wenzhen Li, Meian He, Xiaomin Zhang, Huan Guo, Jing Yuan, Tangchun Wu, Weihong Chen
OBJECTIVE: To examine the independent and combined associations of sleep duration and sleep quality with hypertension in a middle-aged and older Chinese population. METHODS: We included 21,912 individuals aged 62.2 years at baseline from September 2008 to June 2010, and they were followed until October 2013. Sleep duration was self-reported and sleep quality was evaluated with questions designed according to the Pittsburgh Sleep Quality Index. Hypertension was defined as blood pressure ≥140/90 mmHg, or self-reported physician diagnosis of hypertension, or self-reported current use of antihypertensive medication...
December 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29217404/high-density-eeg-characterization-of-brain-responses-to-auditory-rhythmic-stimuli-during-wakefulness-and-nrem-sleep
#11
Caroline Lustenberger, Yogi A Patel, Sankaraleengam Alagapan, Jessica M Page, Betsy Price, Michael R Boyle, Flavio Frohlich
Auditory rhythmic sensory stimulation modulates brain oscillations by increasing phase-locking to the temporal structure of the stimuli and by increasing the power of specific frequency bands, resulting in Auditory Steady State Responses (ASSR). The ASSR is altered in different diseases of the central nervous system such as schizophrenia. However, in order to use the ASSR as biological markers for disease states, it needs to be understood how different vigilance states and underlying brain activity affect the ASSR...
December 4, 2017: NeuroImage
https://www.readbyqxmd.com/read/29214635/kv4-2-channel-activity-controls-intrinsic-firing-dynamics-of-arcuate-kisspeptin-neurons
#12
Philipe R F Mendonça, Victoria Kyle, Shel-Hwa Yeo, William H Colledge, Hugh P C Robinson
Kisspeptin neurons in the hypothalamus are critically involved in reproductive function, via their effect on GnRH neuron activity and consequent gonadotropin release. Kisspeptin neurons show an intrinsic irregularity of firing, but the mechanism of this remains unclear. To address this, we carried out targeted whole-cell patch-clamp recordings of kisspeptin neurons in the arcuate nucleus (Kiss1Arc ), in brain slices isolated from adult male Kiss-Cre:tdTomato mice. Cells fired irregularly in response to constant current stimuli, with a wide range of spike time variability, and prominent subthreshold voltage fluctuations...
December 6, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29212929/nucleic-acid-polymers-are-active-against-hepatitis-delta-virus-infection-in-vitro
#13
Frauke Beilstein, Matthieu Blanchet, Andrew Vaillant, Camille Sureau
In this study, an in vitro infection model for the hepatitis delta virus (HDV) was used to evaluate the antiviral effects of phosphorothioate nucleic acid polymers (NAPs) and investigate their mechanism of action. The results show that NAPs inhibit HDV infection at less than 4 micromolar concentrations in cultures of differentiated human hepatoma cells. NAPs were shown to be active at viral entry, but inactive post entry on HDV RNA replication. Inhibition was independent of the NAPs nucleotide sequence, but dependent on both size and amphipathicity of the polymer...
December 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29194467/sleep-hygiene-education-as-a-treatment-of-insomnia-a-systematic-review-and-meta-analysis
#14
Ka-Fai Chung, Chit-Tat Lee, Wing-Fai Yeung, Man-Sum Chan, Emily Wing-Yue Chung, Wai-Ling Lin
Background: Sleep hygiene education (SHE) is commonly used as a treatment of insomnia in general practice. Whether SHE or cognitive-behavioural therapy for insomnia (CBT-I), a treatment with stronger evidence base, should be provided first remains unclear. Objective: To review the efficacy of SHE for poor sleep or insomnia. Methods: We systematically searched six key electronic databases up until May 2017. Two researchers independently selected relevant publications, extracted data and evaluated methodological quality according to the Cochrane criteria...
November 29, 2017: Family Practice
https://www.readbyqxmd.com/read/29186997/western-diets-are-not-responsible-for-chronic-acid-retention-a-critical-analysis-of-organic-acid-and-phosphate-contribution
#15
Roberto Mioni, Giuseppe Mioni
According to usual literature, the diet-dependent endogenous production of titratable acidity (TA) is contributed by sulphuric and phosphoric acids (NA) and by metabolizable acids (MAs), representing 'net-endogenous acid production' (NEAP). NEAP is mainly neutralised by diet-dependent [Formula: see text] salts of inorganic cations ([Formula: see text]), estimated in foods, faeces and urine from inorganic cation-anion difference (NB). It is claimed that urinary loss of organic acids' anions, '[Formula: see text]', induces metabolizable H+ ions' retention...
November 29, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29175503/non-literal-language-comprehension-in-a-large-sample-of-first-episode-psychosis-patients-in-adulthood
#16
Cinzia Perlini, Marcella Bellani, Livio Finos, Antonio Lasalvia, Chiara Bonetto, Paolo Scocco, Armando D'Agostino, Stefano Torresani, Massimiliano Imbesi, Francesca Bellini, Angela Konze, Angela Veronese, Mirella Ruggeri, Paolo Brambilla
To date no data still exist on the comprehension of figurative language in the early phases of psychosis. The aim of this study is to investigate for the first time the comprehension of metaphors and idioms at the onset of the illness. Two-hundred-twenty eight (228) first episode psychosis (FEP) patients (168 NAP, non-affective psychosis; 60 AP, affective psychosis) and 70 healthy controls (HC) were assessed. Groups were contrasted on: a) type of stimulus (metaphors vs idioms) and b) type of response (OPEN = spontaneous explanations vs CLOSED = multiple choice answer)...
November 10, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29169340/situational-analysis-of-antibiotic-use-and-resistance-in-ghana-policy-and-regulation
#17
Saviour Kwame Yevutsey, Kwame Ohene Buabeng, Moses Aikins, Berko Panyin Anto, Richard B Biritwum, Niels Frimodt-Møller, Martha Gyansa-Lutterodt
BACKGROUND: Antibiotics have played an essential role in decreasing morbidity and mortality from infectious diseases. However, indiscriminate use and unrestricted access is contributing to the emergence of bacterial resistance. This paper reports on a situational analysis of antimicrobial use and resistance in Ghana, with focus on policy and regulation. METHODS: Relevant policy documents, reports, regulations and enactments were reviewed. PubMed and Google search engines were used to extract relevant published papers...
November 23, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29166450/night-work-and-bmi-is-it-related-to-on-shift-napping
#18
Aline Silva-Costa, Rosane Härter Griep, Lúcia Rotenberg
On-shift napping can benefit night workers regarding sleep loss, synchronization of circadian rhythms, and alertness. However, few studies on napping can be found in the literature focused on possible health benefits. This cross-sectional study has investigated the role of on-shift napping on the association between night work and BMI in 409 night-shift nursing professionals. The number of working nights and the years of exposure to night work were significantly associated with increased BMI levels among non-nappers, but not among nappers...
November 17, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29163958/systematic-review-and-meta-analysis-sodium-picosulphate-with-magnesium-citrate-as-bowel-preparation-for-colonoscopy
#19
REVIEW
Ilvy van Lieshout, Isabelle D Munsterman, Anne M Eskes, Jolanda M Maaskant, René van der Hulst
Background: An effective and tolerable bowel preparation is important to secure quality of colonoscopies. It remains unclear if sodium picosulphate with magnesium citrate (SPMC), which is considered a tolerable bowel preparation agent, is also an effective alternative for polyethylene glycol (PEG) and sodium phosphate (NaP). Aim: The aim of this article is to compare effectiveness of SPMC to PEG and NaP through assessment of quality of bowel cleansing measured by validated tools...
November 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29160010/effects-of-a-short-midday-nap-on-habitual-nappers-alertness-mood-and-mental-performance-across-cognitive-domains
#20
Taotao Ru, Qingwei Chen, Jianing You, Guofu Zhou
This study examines whether the benefits of a short midday nap on habitual nappers' mental performance depend on the cognitive domain and the task difficulty. Eighteen healthy college students with the long-term habit of a midday nap (13:00-14:00 hours) participated in a nap-deprivation study. On two separate days with at least 3 days in between, participants either took a nap or remained awake, and were subsequently tested on a simple sustained attention task (Psychomotor Vigilance Test), two more complex attention tasks (Go/No-Go and Flanker task) and one working memory task (2-back)...
November 20, 2017: Journal of Sleep Research
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