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https://www.readbyqxmd.com/read/27926874/multivalent-histone-and-dna-engagement-by-a-phd-brd-pwwp-triple-reader-cassette-recruits-zmynd8-to-k14ac-rich-chromatin
#1
Pavel Savitsky, Tobias Krojer, Takao Fujisawa, Jean-Philippe Lambert, Sarah Picaud, Chen-Yi Wang, Erin K Shanle, Krzysztof Krajewski, Hans Friedrichsen, Alexander Kanapin, Colin Goding, Matthieu Schapira, Anastasia Samsonova, Brian D Strahl, Anne-Claude Gingras, Panagis Filippakopoulos
Elucidation of interactions involving DNA and histone post-translational-modifications (PTMs) is essential for providing insights into complex biological functions. Reader assemblies connected by flexible linkages facilitate avidity and increase affinity; however, little is known about the contribution to the recognition process of multiple PTMs because of rigidity in the absence of conformational flexibility. Here, we resolve the crystal structure of the triple reader module (PHD-BRD-PWWP) of ZMYND8, which forms a stable unit capable of simultaneously recognizing multiple histone PTMs while presenting a charged platform for association with DNA...
December 6, 2016: Cell Reports
https://www.readbyqxmd.com/read/27926844/intracellular-requirements-for-passive-proton-transport-through-the-na-k-atpase
#2
Kevin S Stanley, Dylan J Meyer, Craig Gatto, Pablo Artigas
The Na(+),K(+)-ATPase (NKA or Na/K pump) hydrolyzes one ATP to exchange three intracellular Na+ (Na(+)i) for two extracellular K+ (K(+)o) across the plasma membrane by cycling through a set of reversible transitions between phosphorylated and dephosphorylated conformations, alternately opening ion-binding sites externally (E2) or internally (E1). With subsaturating [Na(+)]o and [K(+)]o, the phosphorylated E2P conformation passively imports protons generating an inward current (IH), which may be exacerbated in NKA-subunit mutations associated with human disease...
December 6, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27926681/influence-of-immediate-and-delayed-lower-limb-amputation-compared-with-lower-limb-salvage-on-functional-and-mental-health-outcomes-post-rehabilitation-in-the-u-k-military
#3
Peter Ladlow, Rhodri Phillip, Russell Coppack, John Etherington, James Bilzon, M Polly McGuigan, Alexander N Bennett
BACKGROUND: Medical practitioners face difficult decisions over whether to amputate or to salvage a lower limb that has undergone trauma. To our knowledge, there has been little evidence reporting the impact of different surgical decisions on functional and mental health outcomes following intensive rehabilitation that might inform decision-making. METHODS: This study is a retrospective, independent-group comparison of rehabilitation outcomes from a U.K. military complex trauma rehabilitation center...
December 7, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27925836/centering-predictor-variables-in-three-level-contextual-models
#4
Ahnalee M Brincks, Craig K Enders, Maria M Llabre, Rebecca J Bulotsky-Shearer, Guillermo Prado, Daniel J Feaster
Hierarchical data are becoming increasingly complex, often involving more than two levels. Centering decisions in multilevel models are closely tied to substantive hypotheses and require researchers to be clear and cautious about their choices. This study investigated the implications of group mean centering (i.e., centering within context; CWC) and grand mean centering (CGM) of predictor variables in three-level contextual models. The goals were to (a) determine equivalencies in the means and variances across the centering options and (b) use the algebraic relationships between the centering choices to clarify the interpretation of the estimated parameters...
December 7, 2016: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/27925681/measuring-medical-students-motivation-to-learning-anatomy-by-cadaveric-dissection
#5
Eiman M Abdel Meguid, Mohammed K Khalil
Motivation and learning are inter-related. It is well known that motivating learners is clearly a complex endeavor, which can be influenced by the educational program and the learning environment. Limited research has been conducted to examine students' motivation as a method to assess the effectiveness of dissection in medical education. This study aimed to assess and analyze students' motivation following their dissection experience. A 29-item survey was developed based on the Attention, Relevance, Confidence, and Satisfaction model of motivation...
December 7, 2016: Anatomical Sciences Education
https://www.readbyqxmd.com/read/27925602/bayesian-intent-prediction-in-object-tracking-using-bridging-distributions
#6
Bashar I Ahmad, James K Murphy, Patrick M Langdon, Simon J Godsill
In several application areas, such as human computer interaction, surveillance and defence, determining the intent of a tracked object enables systems to aid the user/operator and facilitate effective, possibly automated, decision making. In this paper, we propose a probabilistic inference approach that permits the prediction, well in advance, of the intended destination of a tracked object and its future trajectory. Within the framework introduced here, the observed partial track of the object is modeled as being part of a Markov bridge terminating at its destination, since the target path, albeit random, must end at the intended endpoint...
December 2, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/27925326/navigating-physical-activity-engagement-following-a-diagnosis-of-cancer-a-qualitative-exploration
#7
C Cummins, N M Kayes, J Reeve, G Smith, R MacLeod, K M McPherson
This qualitative descriptive study explored cancer survivors' experiences of barriers and facilitators to undertaking physical activity to inform how services and professionals might offer better support. Purposive and theoretical sampling was used to recruit 25 people who were up to 5 years post-cancer diagnosis. Participants took part in face to face, semi-structured interviews, and transcripts were analysed using thematic analysis. The analysis identified five interrelated themes which represented cancer survivors' views: 1) You're on your own-a sense of abandonment post-treatment, and lack of sufficient and tailored information; 2) Dis-ease-disruption to self and identity, and a heightened awareness of physical self and fragility; 3) Becoming acclimatised-physical activity in the face of treatment-related side effects and residual impairment; 4) Importance of others-encouragement and support from health professionals, family and friends, and cancer-specific exercise groups; 5) Meanings people ascribed to physical activity-these were central and could help or hinder engagement...
December 7, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27925324/the-delicate-balance-of-preorganisation-and-adaptability-in-multiply-bonded-host-guest-complexes
#8
Larissa K S von Krbek, Andreas J Achazi, Stefan Schoder, Marius Gaedke, Tobias Biberger, Beate Paulus, Christoph A Schalley
Rigidity and preorganisation are believed to be required for high affinity in multiply bonded supramolecular complexes as they help reducing the entropic penalty of the binding event. This comes at the price that such rigid complexes are sensitive to small geometric mismatches. In marked contrast, nature uses more flexible building blocks. Thus, one might consider putting the rigidity-high affinity notion to the test. Multivalent crown/ammonium complexes are ideal for this purpose as the monovalent interaction is well understood...
December 7, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27924980/coordination-of-bis-azol-1-yl-methane-based-bisphosphines-towards-ru-ii-rh-i-pd-ii-and-pt-ii-synthesis-structural-and-catalytic-studies
#9
Sajad A Bhat, Madhusudan K Pandey, Joel T Mague, Maravanji S Balakrishna
The coordination chemistry of bisphosphine ligands assembled on the five-membered heterocyclic platform of bis(azol-1-yl)methane viz.: bis(2-diphenylphosphinoimidazol-1-yl)methane (1), bis(5-diphenylphosphinopyrazol-1-yl)methane (2) and bis(5-diphenylphosphino-1,2,4-triazol-1-yl)methane (3) with Ru(II), Rh(I), Pd(II) and Pt(II) is described. The bisphosphines 1-3 react with elemental selenium to give the corresponding bis-selenoyl derivatives 4-6. The reactions of 1-3 with transition metal derivatives produce complexes with different coordination modes...
December 7, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27924850/nmr-studies-on-the-interactions-between-yeast-vta1-and-did2-during-the-multivesicular-bodies-sorting-pathway
#10
Jie Shen, Zhongzheng Yang, Jiaolong Wang, Bin Zhao, Wenxian Lan, Chunxi Wang, Xu Zhang, Cody J Wild, Maili Liu, Zhaohui Xu, Chunyang Cao
As an AAA-ATPase, Vps4 is important for function of multivesicular bodies (MVB) sorting pathway, which involves in cellular phenomena ranging from receptor down-regulation to viral budding to cytokinesis. The activity of Vps4 is stimulated by the interactions between Vta1 N-terminus (named as Vta1NTD) and Did2 fragment (176-204 aa) (termed as Did2176-204) or Vps60 (128-186 aa) (termed as Vps60128-186). The structural basis of how Vta1NTD binds to Did2176-204 is still unclear. To address this, in this report, the structure of Did2176-204 in complex with Vta1NTD was determined by NMR techniques, demonstrating that Did2176-204 interacts with Vta1NTD through its helix α6' extending over the 2(nd) and the 3(rd) α-helices of Vta1NTD microtubule interacting and transport 1 (MIT1) domain...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27924583/dissecting-cell-fate-determination-through-integrated-mathematical-modeling-of-the-erk-mapk-signaling-pathway
#11
Sung-Young Shin, Lan K Nguyen
The past three decades have witnessed an enormous progress in the elucidation of the ERK/MAPK signaling pathway and its involvement in various cellular processes. Because of its importance and complex wiring, the ERK pathway has been an intensive subject for mathematical modeling, which facilitates the unraveling of key dynamic properties and behaviors of the pathway. Recently, however, it became evident that the pathway does not act in isolation but closely interacts with many other pathways to coordinate various cellular outcomes under different pathophysiological contexts...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27924337/allosteric-effects-of-gold-nanoparticles-on-human-serum-albumin
#12
Qing Shao, Carol K Hall
The ability of nanoparticles to alter protein structure and dynamics plays an important role in their medical and biological applications. We investigate allosteric effects of gold nanoparticles on human serum albumin protein using molecular simulations. The extent to which bound nanoparticles influence the structure and dynamics of residues distant from the binding site is analyzed. The root mean square deviation, root mean square fluctuation and variation in the secondary structure of individual residues on a human serum albumin protein are calculated for four protein-gold nanoparticle binding complexes...
December 7, 2016: Nanoscale
https://www.readbyqxmd.com/read/27924322/a-cu-ii-complex-targeting-the-translocator-protein-in-vitro-and-in-vivo-antitumor-potential-and-mechanistic-insights
#13
D Montagner, B Fresch, K Browne, V Gandin, A Erxleben
A new Cu-based anticancer metallodrug which targets the translocator protein is reported. [CuBr2(TZ6)] elicits a remarkable in vitro cytotoxicity in sensitive and multidrug resistant cell lines and induces a 98% reduction of tumor mass in a murine tumor model. Target binding was studied by experimental and computational methods.
December 7, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27924216/atrial-fibrillation-management-in-older-heart-failure-patients-a-complex-clinical-problem
#14
REVIEW
Giovanni Pulignano, Donatella Del Sindaco, Maria Denitza Tinti, Stefano Tolone, Giovanni Minardi, Antonio Lax, Massimo Uguccioni
BACKGROUND: Atrial fibrillation (AF) and heart failure (HF), two problems of growing prevalence as a consequence of the ageing population, are associated with high morbidity, mortality, and healthcare costs. AF and HF also share common risk factors and pathophysiologic processes such as hypertension, diabetes mellitus, ischemic heart disease, and valvular heart disease often occur together. Although elderly patients with both HF and AF are affected by worse symptoms and poorer prognosis, there is a paucity of data on appropriate management of these patients...
January 2016: Heart International
https://www.readbyqxmd.com/read/27924004/temporal-association-of-orca-lrwd1-to-late-firing-origins-during-g1-dictates-heterochromatin-replication-and-organization
#15
Yating Wang, Abid Khan, Anna B Marks, Owen K Smith, Sumanprava Giri, Yo-Chuen Lin, Rachel Creager, David M MacAlpine, Kannanganattu V Prasanth, Mirit I Aladjem, Supriya G Prasanth
DNA replication requires the recruitment of a pre-replication complex facilitated by Origin Recognition Complex (ORC) onto the chromatin during G1 phase of the cell cycle. The ORC-associated protein (ORCA/LRWD1) stabilizes ORC on chromatin. Here, we evaluated the genome-wide distribution of ORCA using ChIP-seq during specific time points of G1. ORCA binding sites on the G1 chromatin are dynamic and temporally regulated. ORCA association to specific genomic sites decreases as the cells progressed towards S-phase...
December 6, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27923838/the-effect-of-limited-english-proficiency-on-pediatric-hospital-readmissions
#16
Mindy Ju, Nathan Luna, K T Park
BACKGROUND: The relationship between limited English proficiency (LEP) and worse pediatric health outcomes is well documented. OBJECTIVES: To determine the relationship between LEP status and pediatric hospital readmissions. METHODS: We performed a retrospective cohort analysis of children ≤ 18 years old admitted to a tertiary children's hospital from 2008 to 2014. The main exposure was LEP status. Independent variables included sex, age, race/ethnicity, insurance, median household income, surgical/medical status, severity of illness (SOI), the presence of a complex chronic condition, and length of stay...
December 6, 2016: Hospital Pediatrics
https://www.readbyqxmd.com/read/27923624/a-novel-3d-approach-for-determination-of-frontal-and-coronal-plane-tibial-slopes-from-mr-imaging
#17
Amirhesam Amerinatanzi, Rodney Summers, Kaveh Ahmadi, Vijay K Goel, Timothy E Hewett, Edward Nyman
BACKGROUND: The proximal tibia is geometrically complex, asymmetrical, and variable, is heavily implicated in arthrokinematics of the knee joint, and thus a contributor to knee pathologies such as non-contact anterior cruciate ligament injury. Medial, lateral, and coronal tibial slopes are anatomic parameters that may increase predisposition to knee injuries, but the extent to which each contributes has yet to be fully realized. Previously, two-dimensional methods have quantified tibial slopes, but more reliable 3D methods may prove advantageous...
December 3, 2016: Knee
https://www.readbyqxmd.com/read/27923501/influenza-a-virus-vaccines-for-swine
#18
Amy L Vincent, Daniel R Perez, Daniela Rajao, Tavis K Anderson, Eugenio J Abente, Rasna R Walia, Nicola S Lewis
Economic losses due to influenza A virus (IAV) infections are substantial and a global problem, ranking among the top three major health challenges in the swine industry. Currently, H1 and H3 subtypes circulate in pigs globally associated with different combinations of N1 and N2 subtypes; however, the origin, gene constellation, and antigenic makeup of IAV vary greatly on different continents. Vaccination is one means of mitigating the effects of IAV disease, and vaccines are most effective if the strains included closely match the currently circulating strains in pigs...
November 24, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/27923400/allele-specific-expression-in-the-human-heart-and-its-application-to-postoperative-atrial-fibrillation-and-myocardial-ischemia
#19
Martin I Sigurdsson, Louis Saddic, Mahyar Heydarpour, Tzuu-Wang Chang, Prem Shekar, Sary Aranki, Gregory S Couper, Stanton K Shernan, Jon G Seidman, Simon C Body, Jochen D Muehlschlegel
BACKGROUND: Allele-specific expression (ASE) is differential expression of each of the two chromosomal alleles of an autosomal gene. We assessed ASE patterns in the human left atrium (LA, n = 62) and paired samples from the left ventricle (LV, n = 76) before and after ischemia, and tested the utility of differential ASE to identify genes associated with postoperative atrial fibrillation (poAF) and myocardial ischemia. METHODS: Following genotyping from whole blood and whole-genome sequencing of LA and LV samples, we called ASE using sequences overlapping heterozygous SNPs using rigorous quality control to minimize false ASE calling...
December 6, 2016: Genome Medicine
https://www.readbyqxmd.com/read/27923138/metallogel-templated-synthesis-and-stabilization-of-silver-particles-and-its-application-in-catalytic-reduction-of-nitro-arene
#20
Mukesh Sharma, Plaban Jyoti Sarma, Manash Jyoti Goswami, Kusum K Bania
Metallogel of iron-carboxylates was obtained from trans-1,2-cyclohexanedicarboxylic acid in dimethylformamide (DMF) at basic condition. Spectroscopic and SEM morphology study of the iron-metallogel revealed that the iron complex with dicarboxylic acid was linked together via carboxylates and led to a supramolecular helical like architecture. The synthesized metallogel served as an excellent template for in-situ reduction of silver ion to silver particles micro to nano scale range. Variation of AgNO3 concentration shepherd to change the morphology of the Ag-particles...
November 20, 2016: Journal of Colloid and Interface Science
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