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https://www.readbyqxmd.com/read/28535642/-clinical-effects-of-dynesys-system-and-transfacet-decompression-through-wiltse-approach-in-the-treatment-of-lumbar-degenerative-diseases
#1
K Shang, M J Chen, D G Wang
Objective: To investigate the early clinical effects of Dynesys system and transfacet decompression by Wiltse approach in the treatment of lumbar degenerative diseases. Methods: From January 2010 to December 2013, 48 patients suffering from lumbar degenerative diseases were treated with Dynesys system in addition to transfacet decompression through Wiltse approach.There were 28 males and 20 females with age of (51.8±6.8). The preoperative diagnosis included lumbar spinal stenosis(10 cases); lumber intervertebral disc herniation (38 cases)...
May 23, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28535376/dephosphorylation-of-the-ndc80-tail-stabilizes-kinetochore-microtubule-attachments-via-the-ska-complex
#2
Dhanya K Cheerambathur, Bram Prevo, Neil Hattersley, Lindsay Lewellyn, Kevin D Corbett, Karen Oegema, Arshad Desai
During cell division, genome inheritance is orchestrated by microtubule attachments formed at kinetochores of mitotic chromosomes. The primary microtubule coupler at the kinetochore, the Ndc80 complex, is regulated by Aurora kinase phosphorylation of its N-terminal tail. Dephosphorylation is proposed to stabilize kinetochore-microtubule attachments by strengthening electrostatic interactions of the tail with the microtubule lattice. Here, we show that removal of the Ndc80 tail, which compromises in vitro microtubule binding, has no effect on kinetochore-microtubule attachments in the Caenorhabditis elegans embryo...
May 22, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28535252/trypanosome-rna-editing-mediator-complex-proteins-have-distinct-functions-in-grna-utilization
#3
Rachel M Simpson, Andrew E Bruno, Runpu Chen, Kaylen Lott, Brianna L Tylec, Jonathan E Bard, Yijun Sun, Michael J Buck, Laurie K Read
Uridine insertion/deletion RNA editing is an essential process in kinetoplastid parasites whereby mitochondrial mRNAs are modified through the specific insertion and deletion of uridines to generate functional open reading frames, many of which encode components of the mitochondrial respiratory chain. The roles of numerous non-enzymatic editing factors have remained opaque given the limitations of conventional methods to interrogate the order and mechanism by which editing progresses and thus roles of individual proteins...
May 23, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28535101/design-challenges-of-an-episode-based-payment-model-in-oncology-the-centers-for-medicare-medicaid-services-oncology-care-model
#4
Ronald M Kline, L Daniel Muldoon, Heidi K Schumacher, Larisa M Strawbridge, Andrew W York, Laura K Mortimer, Alison F Falb, Katherine J Cox, Carol Bazell, Ellen W Lukens, Mary C Kapp, Rahul Rajkumar, Amy Bassano, Patrick H Conway
The Centers for Medicare & Medicaid Services developed the Oncology Care Model as an episode-based payment model to encourage participating practitioners to provide higher-quality, better-coordinated care at a lower cost to the nearly three-quarter million fee-for-service Medicare beneficiaries with cancer who receive chemotherapy each year. Episode payment models can be complex. They combine into a single benchmark price all payments for services during an episode of illness, many of which may be delivered at different times by different providers in different locations...
May 23, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28535061/sitting-phase-monolayers-of-polymerizable-phospholipids-create-dimensional-molecular-scale-wetting-control-for-scalable-solution-based-patterning-of-layered-materials
#5
Shi Wah Choong, Shane R Russell, Jae Jin Bang, Justin K Patterson, Shelley A Claridge
The use of dimensionally ordered ligands on layered materials to direct local electronic structure and interactions with the environment promises to streamline integration into nanostructured electronic, optoelectronic, sensing, and nanofluidic interfaces. Substantial progress has been made in using ligands to control substrate electronic structure. Conversely, using the exposed face of the ligand layer to structure wetting and binding interactions, particularly with scalable solution- or spray-processed materials, remains a significant challenge...
May 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28535028/preparation-of-highly-thermally-conductive-polymer-composite-at-low-filler-content-via-a-self-assembly-process-between-polystyrene-microsphere-and-boron-nitride-nanosheet
#6
Xiongwei Wang, Peiyi Wu
Rational distribution and orientation of boron nitride nanosheets (BNNSs) are very significant for a polymer/BNNS composite to obtain a high thermal conductivity at low filler content. In this paper, a high-performance thermal interface material based on exfoliated BNNSs and polystyrene microspheres was fabricated by latex blending and subsequent compression molding. In this case, BNNSs and polystyrene (PS) microspheres would firstly self-asemble to form the complex microspheres via strong electrostatic interactions between them...
May 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28534855/rbc-adherence-of-immune-complexes-containing-botulinum-toxin-improves-neutralization-and-macrophage-uptake
#7
Fetweh H Al-Saleem, Rashmi Sharma, Rama Devudu Puligedda, Md Elias, Chandana Devi Kattala, Paul M Simon, Lance L Simpson, Scott K Dessain
In the paralytic disease botulism, the botulinum neurotoxin (BoNT) passes through the bloodstream to reach and inactivate neuromuscular junctions. Monoclonal antibodies (mAbs) may be useful BoNT countermeasures, as mAb combinations can rapidly clear BoNT from the blood circulation. We have previously shown that the BoNT-neutralizing potency of mAbs can be improved through red blood cell (RBC) immunoadherence. For example, a fusion protein (FP) that adheres biotinylated mAbs to the RBC surface enabled a pair of mAbs to neutralize 5000 LD50 BoNT/A in the mouse protection assay...
May 19, 2017: Toxins
https://www.readbyqxmd.com/read/28534574/syntheses-structures-and-magnetic-properties-of-a-family-of-end-on-azido-bridged-cu-ii-ln-iii-complexes
#8
Xing-Cai Huang, Xin-Hua Zhao, Dong Shao, Xin-Yi Wang
The reaction of Cu(valdmpn) (H2valdmpn = N,N'-bis-(3-methoxysalicylidene)-1,3-diamino-2,2-dimethylpropane), LnCl3·nH2O (Ln = La(1), Ce (2), Pr(3), Nd(4), Sm(5), Eu(6), Gd(7), Tb(8), Dy(9), Ho(10), Er(11), Tm(12), Yb(13), Lu(14)) and NaN3 in methanol led to a whole series of heterometallic Cu(II)-Ln(III) complexes. The basic structural components of these complexes are the [Cu(II)(valdmpn)Ln(III)] units with a compartmental Schiff-base ligand. These [Cu(II)Ln(III)] units were then further connected by the end-on (EO) azides between the Ln(3+) centers to form tetranuclear {[CuLn](μ-N3)n[LnCu]} motifs, where n is 3 for the complexes of larger radii lanthanides (1CuLa to 5CuSm) and 2 for the complexes of smaller radii lanthanides (6CuEu to 14CuLu)...
May 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28534565/lanthanoplatins-emissive-eu-iii-and-tb-iii-complexes-staining-nucleoli-targeted-through-pt-dna-crosslinking
#9
Khushbu Singh, Swati Singh, Payal Srivastava, Sri Sivakumar, Ashis K Patra
Two highly luminescent water-soluble heterometallic LnPt2 complexes, [{cis-PtCl(NH3)2}2Ln(L)(H2O)](NO3)2 (Ln = Eu (1), Tb (2)), have been designed for their selective nucleoli staining through formation of Pt-DNA crosslinks. The complexes showed significant cellular uptake and distinctive nucleoli localization through intrinsic emission from Eu(III) or Tb(III) observed through confocal fluorescence microscopy.
May 23, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28534509/a-novel-interaction-of-pak4-with-ppar%C3%AE-to-regulate-nox1-and-radiation-induced-epithelial-to-mesenchymal-transition-in-glioma
#10
D Kesanakurti, D Maddirela, Y K Banasavadi-Siddegowda, T-H Lai, Z Qamri, N K Jacob, D Sampath, S Mohanam, B Kaur, V K Puduvalli
Tumor recurrence in glioblastoma (GBM) is, in part, attributed to increased epithelial-to-mesenchymal transition (EMT) and enhanced tumor cell dissemination in adjacent brain parenchyma after ionizing radiation (IR). EMT is associated with aggressive behavior, increased stem-like characteristics and treatment resistance in malignancies; however, the underlying signaling mechanisms that regulate EMT are poorly understood. We identified grade-dependent p21-activated kinases 4 (PAK4) upregulation in gliomas and further determined its role in mesenchymal transition and radioresistance...
May 22, 2017: Oncogene
https://www.readbyqxmd.com/read/28534506/lsd1-demethylates-hif1%C3%AE-to-inhibit-hydroxylation-and-ubiquitin-mediated-degradation-in-tumor-angiogenesis
#11
J-Y Lee, J-H Park, H-J Choi, H-Y Won, H-S Joo, D-H Shin, M K Park, B Han, K P Kim, T J Lee, C M Croce, G Kong
Lysine-specific demethylase 1 (LSD1), which has been considered as a potential therapeutic target in human cancer, has been known to regulate many biological functions through its non-histone substrates. Although LSD1-induced hypoxia-inducible factor alpha (HIF1α) demethylation has recently been proposed, the effect of LSD1 on the relationship between HIF1α post-translational modifications (PTMs) and HIF1α-induced tumor angiogenesis remains to be elucidated. Here, we identify a new methylation site of the HIF1α protein antagonized by LSD1 and the interplay between HIF1α protein methylation and other PTMs in regulating tumor angiogenesis...
May 22, 2017: Oncogene
https://www.readbyqxmd.com/read/28534489/long-term-mutual-phase-locking-of-picosecond-pulse-pairs-generated-by-a-semiconductor-nanowire-laser
#12
B Mayer, A Regler, S Sterzl, T Stettner, G Koblmüller, M Kaniber, B Lingnau, K Lüdge, J J Finley
The ability to generate phase-stabilized trains of ultrafast laser pulses by mode-locking underpins photonics research in fields, such as precision metrology and spectroscopy. However, the complexity of conventional mode-locked laser systems has hindered their realization at the nanoscale. Here we demonstrate that GaAs-AlGaAs nanowire lasers are capable of emitting pairs of phase-locked picosecond laser pulses with a repetition frequency up to 200 GHz when subject to incoherent pulsed optical excitation. By probing the two-pulse interference spectra, we show that pulse pairs remain mutually coherent over timescales extending to 30 ps, much longer than the emitted laser pulse duration (≤3 ps)...
May 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28534475/strain-engineering-of-monoclinic-domains-in-k-x-na1-x-nbo3-epitaxial-layers-a-pathway-to-enhanced-piezoelectric-properties
#13
Martin Schmidbauer, Dorothee Braun, Toni Markurt, Michael Hanke, Jutta Schwarzkopf
A novel concept to obtain a ferroelectric material with enhanced piezoelectric properties is proposed. This approach is based on the combination of two pathways: (i) the evolution of a ferroelectric monoclinic phase and, (ii) the coexistence of different types of ferroelectric domains leading to polarization discontinuities at the domain walls. Each of these pathways enables polarization rotation in the material which is responsible for giant piezoelectricity. Targeted incorporation of anisotropic epitaxial lattice strain is used to implement this approach...
May 23, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28534432/gastrointestinal-microphysiological-systems
#14
Sarah E Blutt, James R Broughman, Winnie Zou, Xi-Lei Zeng, Umesh C Karandikar, Julie In, Nicholas C Zachos, Olga Kovbasnjuk, Mark Donowitz, Mary K Estes
Gastrointestinal diseases are a significant health care and economic burden. Prevention and treatment of these diseases have been limited by the available human biologic models. Microphysiological systems comprise organ-specific human cultures that recapitulate many structural, biological, and functional properties of the organ in smaller scale including aspects of flow, shear stress and chemical gradients. The development of intestinal microphysiological system platforms represents a critical component in improving our understanding, prevention, and treatment of gastrointestinal diseases...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28534410/a-facile-methodology-for-the-development-of-printable-and-flexible-all-solid-state-rechargeable-battery
#15
Bibekananda De, Amit Yadav, Salman Khan, Kamal K Kar
Development of the printable and flexible energy storage device is one of the most promising technologies for wearable electronics in textile industry. The present work design a printable and flexible all solid state rechargeable battery for wearable electronic in textile application. Copper coated carbon fiber is used to make polyethylene oxide (PEO) based polymer nanocomposite for flexible and conductive current collector layer. Lithium iron phosphate (LiFePO4) and titanium dioxide (TiO2) are utilized to prepare cathode and anode layer, respectively with PEO and carbon black composites...
May 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28534406/relationships-between-exciton-dissociation-and-slow-recombination-within-znse-cds-and-cdse-cds-dot-in-rod-heterostructures
#16
Amanda N Grennell, James K Utterback, Orion M Pearce, Molly B Wilker, Gordana Dukovic
Type-II and quasi type-II heterostructure nanocrystals are known to exhibit extended excited-state lifetimes compared to their single material counterparts because of reduced wavefunction overlap between the electron and hole. However, due to fast and efficient hole trapping and non-uniform morphologies, the photophysics of dot-in-rod heterostructures are more rich and complex than this simple picture. Using transient absorption spectroscopy, we observe that the behavior of electrons in the CdS "rod" or "bulb" regions of non-uniform ZnSe/CdS and CdSe/CdS dot-in-rods is similar regardless of the "dot" material, which supports previous work demonstrating that hole trapping and particle morphology drive electron dynamics...
May 23, 2017: Nano Letters
https://www.readbyqxmd.com/read/28534306/assessment-of-water-quality-using-multivariate-techniques-in-river-sosiani-kenya
#17
A O Achieng', P O Raburu, E C Kipkorir, S O Ngodhe, K O Obiero, J Ani-Sabwa
Multivariate techniques can infer intrinsic characteristics of complex data by generating correlation, similarity, dissimilarity, and covariance vector matrix to ascertain their relationships. The study evaluated the effect of anthropogenic activities by analyzing selected physicochemical water quality parameters (WQP) as indicators of pollution in River Sosiani, located in western Kenya, at six stations from August 2012 to February 2013 (Aug-Oct ≡ wet season, Nov-Feb ≡ Dry season). Temperature, pH, Total Dissolved Solids (TDS), conductivity, and Dissolved Oxygen (DO) were measured in situ while Total Phosphorus (TP), Total Organic Nitrogen (TON), and Biologial Oxygen Demand (BOD) were measured in vitro using standard methods...
June 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28534165/-the-german-research-network-cure-net-a-benefit-for-patients-with-rare-diseases
#18
REVIEW
A-K Ebert
With the help of the media, there is growing public awareness for the problems associated with rare diseases and their impact on the lives of those affected and their families. Bladder exstrophy-epispadias complex (BEEC) is also a part of the group of rare diseases within the urological field. The German network CURE-Net was founded in 2009 to systematically collect data regarding the epidemiological and molecular causes, and clinical and psychosocial effects of congenital urorectal malformations. With the help of self-help groups a national registry could be established for systematic data retrieval...
May 22, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28534009/genomic-insight-into-mechanisms-of-reversion-of-antibiotic-resistance-in-multidrug-resistant-mycobacterium-tuberculosis-induced-by-a-nanomolecular-iodine-containing-complex-fs-1
#19
Aleksandr I Ilin, Murat E Kulmanov, Ilya S Korotetskiy, Rinat A Islamov, Gulshara K Akhmetova, Marina V Lankina, Oleg N Reva
Drug induced reversion of antibiotic resistance is a promising way to combat multidrug resistant infections. However, lacking knowledge of mechanisms of drug resistance reversion impedes employing this approach in medicinal therapies. Induction of antibiotic resistance reversion by a new anti-tuberculosis drug FS-1 has been reported. FS-1 was used in this work in combination with standard anti-tuberculosis antibiotics in an experiment on laboratory guinea pigs infected with an extensively drug resistant (XDR) strain Mycobacterium tuberculosis SCAID 187...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28533516/asd-restricted-and-repetitive-behaviors-associated-at-17q21-33-genes-prioritized-by-expression-in-fetal-brains
#20
R M Cantor, L Navarro, H Won, R L Walker, J K Lowe, D H Geschwind
Autism spectrum disorder (ASD) is a behaviorally defined condition that manifests in infancy or early childhood as deficits in communication skills and social interactions. Often, restricted and repetitive behaviors (RRBs) accompany this disorder. ASD is polygenic and genetically complex, so we hypothesized that focusing analyses on intermediate core component phenotypes, such as RRBs, can reduce genetic heterogeneity and improve statistical power. Applying this approach, we mined Caucasian genome-wide association studies (GWAS) data from two of the largest ASD family cohorts, the Autism Genetics Resource Exchange and Autism Genome Project (AGP)...
May 23, 2017: Molecular Psychiatry
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