keyword
https://read.qxmd.com/read/38547486/sulfonate-functional-ultramicroporous-materials-with-suitable-pore-size-and-layer-stacked-structure-for-c4-olefins-purification
#1
JOURNAL ARTICLE
Zhensong Qiu, Jiyu Cui, Lifeng Yang, Zhaoqiang Zhang, Xian Suo, Xili Cui, Huabin Xing
Selective recognition of 1,3-butadiene from complex olefin isomers is vital for 1,3-butadiene purification, but the lack of porous materials with suitable pore structures results in poor selectivity and low capacity in C4 olefin separation. Herein, two sulfonate-functionalized organic frameworks, ZU-601 and ZU-602, are designed and show impressive separation performance toward C4 olefins. Benefiting from the suitable aperture size caused by the flexibility of coordinated organic ligand, ZU-601, ZU-602 that are pillared with different sulfonate anions could discriminate C4 olefin isomers with high uptake ratio: 1,3-butadiene/1-butene (207), 1,3-butadiene/ trans -2-butene (10...
March 28, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38547416/characterizing-barriers-and-facilitators-of-metabolic-bariatric-surgery-tourism-a-systematic-review
#2
JOURNAL ARTICLE
Sharukh Zuberi, Abdullah Egiz, Hasan Iqbal, Periyathambi Jambulingam, Douglas Whitelaw, Tanveer Adil, Vigyan Jain, Omar Al-Taan, Aruna Munasinghe, Alan Askari, Mohamed K Aly, Fahad M Iqbal
BACKGROUND: Metabolic bariatric surgery tourism continues to rise and has become a growing concern for bariatric surgeons globally. With varying degrees of regulation, counselling and success, those that develop complications may have to deal with a multitude of challenges often distant from their country of operation. The aim of this study was to characterize the barriers and facilitators influencing individuals to undergo metabolic bariatric surgery tourism, in order to better understand the implications to the National Health Service and other healthcare systems...
March 2, 2024: British Journal of Surgery
https://read.qxmd.com/read/38547292/control-of-cell-proliferation-by-memories-of-mitosis
#3
JOURNAL ARTICLE
Franz Meitinger, Hazrat Belal, Robert L Davis, Mallory B Martinez, Andrew K Shiau, Karen Oegema, Arshad Desai
Mitotic duration is tightly constrained, and extended mitosis is characteristic of problematic cells prone to chromosome missegregation and genomic instability. We show here that mitotic extension leads to the formation of p53-binding protein 1 (53BP1)-ubiquitin-specific protease 28 (USP28)-p53 protein complexes that are transmitted to, and stably retained by, daughter cells. Complexes assembled through a Polo-like kinase 1-dependent mechanism during extended mitosis and elicited a p53 response in G1 that prevented the proliferation of the progeny of cells that experienced an approximately threefold extended mitosis or successive less extended mitoses...
March 29, 2024: Science
https://read.qxmd.com/read/38547289/molecular-mechanism-of-dynein-dynactin-complex-assembly-by-lis1
#4
JOURNAL ARTICLE
Kashish Singh, Clinton K Lau, Giulia Manigrasso, José B Gama, Reto Gassmann, Andrew P Carter
Cytoplasmic dynein is a microtubule motor vital for cellular organization and division. It functions as a ~4-megadalton complex containing its cofactor dynactin and a cargo-specific coiled-coil adaptor. However, how dynein and dynactin recognize diverse adaptors, how they interact with each other during complex formation, and the role of critical regulators such as lissencephaly-1 (LIS1) protein (LIS1) remain unclear. In this study, we determined the cryo-electron microscopy structure of dynein-dynactin on microtubules with LIS1 and the lysosomal adaptor JIP3...
March 29, 2024: Science
https://read.qxmd.com/read/38547110/what-influences-stroke-survivors-with-physical-disabilities-to-be-physically-active-a-qualitative-study-informed-by-the-theoretical-domains-framework
#5
JOURNAL ARTICLE
L K Kwah, K Doshi, D A De Silva, W M Ng, S Thilarajah
BACKGROUND: Although the benefits of regular physical activity (PA) after stroke are well established, many stroke survivors do not achieve recommended PA levels. To date, studies exploring determinants to PA have not used a behaviour change theory and focused on stroke survivors with physical disabilities. As a precursor to an intervention development study, we aimed to use the Theoretical Domains Framework (TDF) to identify factors influencing PA in stroke survivors with physical disabilities in Singapore...
2024: PloS One
https://read.qxmd.com/read/38547025/birth-prevalence-of-sickle-cell-disease-and-county-level-social-vulnerability-sickle-cell-data-collection-program-11-states-2016-2020
#6
JOURNAL ARTICLE
Mariam Kayle, Audrey L Blewer, Wei Pan, Jennifer A Rothman, Carri S Polick, Joshua Rivenbark, Elliott Fisher, Camila Reyes, John J Strouse, Shelby Weeks, Jay R Desai, Angela B Snyder, Mei Zhou, Ankit Sutaria, Jhaqueline Valle, Sophia S Horiuchi, Marci K Sontag, Joshua I Miller, Ashima Singh, Mahua Dasgupta, Isaac A Janson, Najibah Galadanci, Sarah L Reeves, Krista Latta, Isabel Hurden, Shamaree J Cromartie, Allison P Plaxco, Ayesha Mukhopadhyay, Matthew P Smeltzer, Mary Hulihan
Sickle cell disease (SCD) remains a public health priority in the United States because of its association with complex health needs, reduced life expectancy, lifelong disabilities, and high cost of care. A cross-sectional analysis was conducted to calculate the crude and race-specific birth prevalence for SCD using state newborn screening program records during 2016-2020 from 11 Sickle Cell Data Collection program states. The percentage distribution of birth mother residence within Social Vulnerability Index quartiles was derived...
March 28, 2024: MMWR. Morbidity and Mortality Weekly Report
https://read.qxmd.com/read/38546987/concatenated-nanopore-dna-codes
#7
JOURNAL ARTICLE
Adrian Vidal, V B Wijekoon, Emanuele Viterbo
In nanopore sequencers, single-stranded DNA molecules (or k-mers) enter a small opening in a membrane called a nanopore and modulate the ionic current through the pore, producing a channel output in the form of a noisy piecewise constant signal. An important problem in DNA-based data storage is finding a set of k-mers, i.e. a DNA code, that is robust against noisy sample duplication introduced by nanopore sequencers. Good DNA codes should contain as many k-mers as possible that produce distinguishable current signals (squiggles) as measured by the sequencer...
April 2024: IEEE Transactions on Nanobioscience
https://read.qxmd.com/read/38546898/host-and-geography-impact-virus-diversity-in-new-zealand-s-longfin-and-shortfin-eels
#8
JOURNAL ARTICLE
Stephanie J Waller, Eimear Egan, Shannan Crow, Anthony Charsley, P Mark Lokman, Erica K Williams, Edward C Holmes, Jemma L Geoghegan
The fishing and aquaculture industry is vital for global food security, yet viral diseases can result in mass fish die-off events. Determining the viromes of traditionally understudied species, such as fish, enhances our understanding of the global virosphere and the factors that influence virome composition and disease emergence. Very little is known about the viruses present in New Zealand's native fish species, including the shortfin eel (Anguilla australis) and the longfin eel (Anguilla dieffenbachii), both of which are fished culturally by Māori (the indigenous population of New Zealand) and commercially...
March 28, 2024: Archives of Virology
https://read.qxmd.com/read/38546735/unveiling-genome-plasticity-and-a-novel-phage-in-mycoplasma-felis-genomic-investigations-of-four-feline-isolates
#9
JOURNAL ARTICLE
Sara M Klose, Alistair R Legione, Rhys N Bushell, Glenn F Browning, Paola K Vaz
Mycoplasma felis has been isolated from diseased cats and horses, but to date only a single fully assembled genome of this species, of an isolate from a horse, has been characterized. This study aimed to characterize and compare the completely assembled genomes of four clinical isolates of M. felis from three domestic cats, assembled with the aid of short- and long-read sequencing methods. The completed genomes encoded a median of 759 ORFs (range 743-777) and had a median average nucleotide identity of 98.2 % with the genome of the available equid origin reference strain...
March 2024: Microbial Genomics
https://read.qxmd.com/read/38546717/metal-centered-boron-wheel-cluster-of-y%C3%A2-b-11-2-with-rare-d-11-h-symmetry
#10
JOURNAL ARTICLE
Xin-Ran Dong, Jing-Xuan Zhang, Teng-Teng Chen, Cong-Qiao Xu, Jun Li
Molecules with high point-group symmetry are interesting prototype species in the textbook. As transition metal-centered boron clusters tend to have highly symmetric structures to fulfill multicenter bonding and high stability, new boron clusters with rare point-group symmetry may be viable. Through in-depth scrutiny over the structures of experimentally already observed transition metal-centered boron-wheel complexes, geometric and electronic design principles are summarized, based on which we studied M©B11 k - ( M = Y, La; Zr, Hf; k = 1, 2) clusters and found that a Y©B11 2- boron-wheel complex has an unprecedented D 11 h point-group symmetry...
March 28, 2024: Inorganic Chemistry
https://read.qxmd.com/read/38546609/in-vitro-assays-for-immuno-oncology-drug-efficacy-assessment-and-screening-for-personalized-cancer-therapy-scopes-and-challenges
#11
REVIEW
Marufur Rahman, Greg Wells, Juha K Rantala, Thomas Helleday, Munitta Muthana, Sarah J Danson
INTRODUCTION: Immunotherapies have revolutionized cancer treatment, but often fail to produce desirable therapeutic outcomes in all patients. Due to the inter-patient heterogeneity and complexity of the tumor microenvironment, personalized treatment approaches are gaining demand. Researchers have long been using a range of in-vitro assays including 2D models, organoid co-cultures, and cancer-on-a-chip platforms for cancer drug screening. A comparative analysis of these assays with their suitability, high-throughput capacity, and clinical translatability is required for optimal translational use...
March 28, 2024: Expert Review of Clinical Immunology
https://read.qxmd.com/read/38546485/room-temperature-spin-crossover-properties-in-a-series-of-mixed-anion-fe-nh-2-trz-3-bf-4-2-x-sif-6-x-2-complexes
#12
JOURNAL ARTICLE
Xinyu Yang, Alejandro Enriquez-Cabrera, Kane Jacob, Yannick Coppel, Lionel Salmon, Azzedine Bousseksou
A series of mixed-anion Fe(NH2 trz)3 (BF4 )2- x (SiF6 ) x /2 spin crossover complexes is obtained modifying the reaction time but also using an increase amount of tetraethyl orthosilicate as the source for the production and the incorporation of SiF6 2- competing with the BF4 2- anions present in the mother solution. The increase of the SiF6 2- anion inclusion to the detriment of the BF4 - counterpart induces a shift of the temperature transition toward high temperatures leading to interesting bistability properties around room temperature with T 1/2 spanning from 300 K to 325 K...
March 28, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry
https://read.qxmd.com/read/38546345/generation-and-application-of-aryl-radicals-under-photoinduced-conditions
#13
JOURNAL ARTICLE
Anupam Das, K R Justin Thomas
Photoinduced aryl radical generation is a powerful strategy in organic synthesis that facilitates the formation of diverse carbon-carbon and carbon-heteroatom bonds.  The synthetic applications of photoinduced aryl radical formation in the synthesis of complex organic compounds, including natural products, physiologically significant molecules, and functional materials, have received immense attention. An overview of current developments in photoinduced aryl radical production methods and their uses in organic synthesis is given in this article...
March 28, 2024: Chemistry: a European Journal
https://read.qxmd.com/read/38546335/expanding-the-scope-of-self-assembled-supramolecular-biosensors-a-highly-selective-and-sensitive-enzyme-responsive-aie-based-fluorescent-biosensor-for-trypsin-detection-and-inhibitor-screening
#14
JOURNAL ARTICLE
Jasvir Kaur, Harshad A Mirgane, Vrushali S Patil, Geetika M Ahlawat, Sheshanath V Bhosale, Prabhat K Singh
Trypsin, a pancreatic enzyme associated with diseases like pancreatic cancer and cystic fibrosis, requires effective diagnostic tools. Current detection systems seldom utilize macrocyclic molecules and tetraphenyl ethylene (TPE) derivative-based supramolecular assemblies, known for their biocompatibility and aggregation-induced emission (AIE) properties, for trypsin detection. This study presents an enzyme-responsive, AIE-based fluorescence 'Turn-On' sensing platform for trypsin detection, employing sulfated-β-cyclodextrin (S-βCD), an imidazolium derivative of TPE (TPE-IM), and protamine sulfate (PrS)...
March 28, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38545959/mononuclear-fe-iii-complexes-with-2-4-dichloro-6-quinoline-8-ylimino-methyl-phenolate-synthesis-structure-and-magnetic-behavior
#15
JOURNAL ARTICLE
Ah Rim Jeong, Si Ra Park, Jong Won Shin, Jihyun Kim, Ryuya Tokunaga, Shinya Hayami, Kil Sik Min
Three Fe(III)-based coordination complexes [Fe(dqmp)2 ](NO3 )·H2 O (1), [Fe(dqmp)2 ](BF4 )·2CH3 COCH3 (2), and [Fe(dqmp)2 ](ClO4 ) (3) were synthesized from Fe(NO3 )3 ·9H2 O/Fe(ClO4 )3 ·xH2 O, NaBF4 , and 2,4-dichloro-6-((quinoline-8-ylimino)methyl)phenol (Hdqmp) in methanol/acetone and characterized. The structures of complexes 1-3 were determined via single-crystal X-ray crystallography at 100 K and room temperature, and their magnetic properties in the solid and solution forms were investigated...
March 28, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry
https://read.qxmd.com/read/38545953/mercury-group-13-metal-covalent-bonds-a-systematic-comparison-of-aluminyl-gallyl-and-indyl-metallo-ligands
#16
JOURNAL ARTICLE
Liam Griffin, Mathias Ellwanger, Agamemnon Crumpton, Matthew Roy, Andreas Heilmann, Simon Aldridge
Bimetallic compounds containing direct metal-group 13 element bonds have been shown to display unprecedented patterns of cooperative reactivity towards small molecules, which can be influenced by the identity of the group 13 element. In this context, we present here a systematic appraisal of group 13 metallo-ligands of the type [(NON)E]- (NON = 4,5-bis(2,6-diisopropylanilido)-2,7-di-tert-butyl-9,9-dimethylxanthene) for E = Al, Ga and In, through a comparison of structural and spectroscopic parameters associated with the trans L or X ligands in linear d10 complexes of the types LM{E(NON)} and XM'{E(NON)}...
March 28, 2024: Angewandte Chemie
https://read.qxmd.com/read/38545597/a-rare-case-report-of-osteosarcoma-of-maxilla-with-double-free-flap-reconstruction
#17
Surendra K Dabas, Nandini N Menon, Reetesh Ranjan, Himanshu Shukla, Bikas Gurung, Sukirti Tiwari, Yash Chaddha, Ajit Sinha, Rahul Kapoor, Vinay Kumar Verma, Saurabh Arora, Ashwani Sharma, Jasbir Singh, Rishu Singal, Sandeep Kumar Mohan, Seema Sachan
Osteosarcomas are rare and highly malignant bone tumours which are composed of malignant mesenchymal cells producing osteoid or immature bone. Maxillary osteosarcomas are rare tumours accounting for less than 1% of head and neck malignancies. Aggressive surgical resection is the main modality of treatment with good reconstruction. Due to the complex anatomy and location of maxilla as well as its proximity to the skull, resection with negative margins is always a challenge and so is the reconstruction so as to reduce the morbidity of the patient and to also give a good functional and cosmetic outcome...
March 2024: Indian Journal of Surgical Oncology
https://read.qxmd.com/read/38545547/aiming-the-magic-bullet-targeted-delivery-of-imaging-and-therapeutic-agents-to-solid-tumors-by-phlip-peptides
#18
REVIEW
Yana K Reshetnyak, Oleg A Andreev, Donald M Engelman
The family of pH (Low) Insertion Peptides (pHLIP) comprises a tumor-agnostic technology that uses the low pH (or high acidity) at the surfaces of cells within the tumor microenvironment (TME) as a targeted biomarker. pHLIPs can be used for extracellular and intracellular delivery of a variety of imaging and therapeutic payloads. Unlike therapeutic delivery targeted to specific receptors on the surfaces of particular cells, pHLIP targets cancer, stromal and some immune cells all at once. Since the TME exhibits complex cellular crosstalk interactions, simultaneous targeting and delivery to different cell types leads to a significant synergistic effect for many agents...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38544976/exploring-biosurfactant-from-halobacterium-jilantaiense-as-drug-against-hiv-and-zika-virus-fabrication-characterization-cytosafety-property-molecular-docking-and-molecular-dynamics-simulation
#19
JOURNAL ARTICLE
Mohammed S Almuhayawi, Naglaa Elshafey, Nashwa Hagagy, Samy Selim, Soad K Al Jaouni, Ahmed R Sofy, Mennatalla Samy, Hattan S Gattan, Mohammed H Alruhaili, Mohanned Talal Alharbi, Mohammed K Nagshabandi, Muyassar K Tarabulsi, Mohamed E Elnosary
Biosurfactants are surface-active molecules with unique qualities and various uses. Many microorganisms produce secondary metabolites with surface-active characteristics that serve various antiviral functions. The HIV and Zika viruses were chosen for this study because they can spread from mother to child and result in potentially fatal infections in infants. Halophilic bacteria from the Red Sea solar saltern in Egypt were screened using drop collapse, emulsification activity, and oil displacement assays to produce biosurfactants and emulsifiers...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38544958/bayesian-estimation-methods-for-survey-data-with-potential-applications-to-health-disparities-research
#20
JOURNAL ARTICLE
Stephanie M Wu, Briana Joy K Stephenson
Understanding how and why certain communities bear a disproportionate burden of disease is challenging due to the scarcity of data on these communities. Surveys provide a useful avenue for accessing hard-to-reach populations, as many surveys specifically oversample understudied and vulnerable populations. When survey data is used for analysis, it is important to account for the complex survey design that gave rise to the data, in order to avoid biased conclusions. The field of Bayesian survey statistics aims to account for such survey design while leveraging the advantages of Bayesian models, which can flexibly handle sparsity through borrowing of information and provide a coherent inferential framework to easily obtain variances for complex models and data types...
2024: Wiley Interdisciplinary Reviews. Computational Statistics
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