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Human body anatomy

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https://www.readbyqxmd.com/read/28646272/rhesus-cochlear-and-vestibular-functions-are-preserved-after-inner-ear-injection-of-saline-volume-sufficient-for-gene-therapy-delivery
#1
Chenkai Dai, Mohamed Lehar, Daniel Q Sun, Lani Swarthout Rvt, John P Carey, Tim MacLachlan, Doug Brough, Hinrich Staecker, Alexandra M Della Santina, Timothy E Hullar, Charles C Della Santina
Sensorineural losses of hearing and vestibular sensation due to hair cell dysfunction are among the most common disabilities. Recent preclinical research demonstrates that treatment of the inner ear with a variety of compounds, including gene therapy agents, may elicit regeneration and/or repair of hair cells in animals exposed to ototoxic medications or other insults to the inner ear. Delivery of gene therapy may also offer a means for treatment of hereditary hearing loss. However, injection of a fluid volume sufficient to deliver an adequate dose of a pharmacologic agent could, in theory, cause inner ear trauma that compromises functional outcome...
June 23, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28638930/-different-adipose-tissue-depots-and-metabolic-syndrome-in-human
#2
Ran Wang, Xiao-Nan Li
Obesity is characterized by abnormal and excessive adipose tissue accumulated in the body. Compared with peripheral obesity (the accumulation of subcutaneous adipose tissue), abdominal obesity (the accumulation of visceral adipose tissue) is associated with increased risk of the metabolic syndrome, such as diabetes, hypertension, atherosclerosis, and dyslipidemia. Adipose tissue is a highly heterogeneous endocrine organ. Adipose tissue depots differ significantly in anatomy, cell biology, glucose and lipid metabolism as well as in endocrine regulation...
June 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28575538/willingness-toward-organ-and-body-donation-among-anatomy-professors-and-students-in-mexico
#3
Alejandro Quiroga-Garza, Cynthia Guadalupe Reyes-Hernández, Pablo Patricio Zarate-Garza, Claudia Nallely Esparza-Hernández, Jorge Gutierrez-de la O, David de la Fuente-Villarreal, Rodrigo Enrique Elizondo-Omaña, Santos Guzman-Lopez
Most anatomists agree that cadaver dissection serves as a superior teaching tool in human anatomy education. However, attitudes toward body donation vary widely between different individuals. A questionnaire was developed to determine the attitudes toward body and organ donation among those who learn the most from cadavers: medical students, medical student teaching assistants, medical students involved in research, and anatomy professors. A cross-sectional, prospective study was designed in which the questionnaire was distributed among first-year human anatomy students before undertaking cadaver dissection at the beginning of the semester, and then again after a commemoration service at the end of the course...
June 2, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28575530/the-skeletons-in-our-closet-e-learning-tools-and-what-happens-when-one-side-does-not-fit-all
#4
Sonya E Van Nuland, Kem A Rogers
In the anatomical sciences, e-learning tools have become a critical component of teaching anatomy when physical space and cadaveric resources are limited. However, studies that use empirical evidence to compare their efficacy to visual-kinesthetic learning modalities are scarce. The study examined how a visual-kinesthetic experience, involving a physical skeleton, impacts learning when compared with virtual manipulation of a simple two-dimensional (2D) e-learning tool, A.D.A.M. Interactive Anatomy. Students from The University of Western Ontario, Canada (n = 77) participated in a dual-task study to: (1) investigate if a dual-task paradigm is an effective tool for measuring cognitive load across these different learning modalities; and (2) to assess the impact of knowledge recall and spatial ability when using them...
June 2, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28570033/quantitative-mri-and-spectroscopy-of-bone-marrow
#5
REVIEW
Dimitrios C Karampinos, Stefan Ruschke, Michael Dieckmeyer, Maximilian Diefenbach, Daniela Franz, Alexandra S Gersing, Roland Krug, Thomas Baum
Bone marrow is one of the largest organs in the human body, enclosing adipocytes, hematopoietic stem cells, which are responsible for blood cell production, and mesenchymal stem cells, which are responsible for the production of adipocytes and bone cells. Magnetic resonance imaging (MRI) is the ideal imaging modality to monitor bone marrow changes in healthy and pathological states, thanks to its inherent rich soft-tissue contrast. Quantitative bone marrow MRI and magnetic resonance spectroscopy (MRS) techniques have been also developed in order to quantify changes in bone marrow water-fat composition, cellularity and perfusion in different pathologies, and to assist in understanding the role of bone marrow in the pathophysiology of systemic diseases (e...
June 1, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28547783/aortic-arch-origin-of-the-left-vertebral-artery-an-anatomical-and-radiological-study-with-significance-for-avoiding-complications-with-anterior-approaches-to-the-cervical-spine
#6
Gabrielle G Tardieu, Bryan Edwards, Fernando Alonso, Koichi Watanabe, Tsuyoshi Saga, Moriyoshi Nakamura, Mayuko Motomura, Raghu Sampath, Joe Iwanaga, Oded Goren, Stephen Monteith, Rod J Oskouian, Marios Loukas, R Shane Tubbs
INTRODUCTION: Complications from anterior approaches to the cervical spine are uncommon with normal anatomy. However, variant anatomy might predispose one to an increased incidence of injury during such procedures. We hypothesized that left vertebral arteries that arise from the aortic arch instead of the subclavian artery might take a more medial path in their ascent making them more susceptible to iatrogenic injury. MATERIALS AND METHODS: Fifty human adult cadavers were examined for left vertebral arteries having an aortic arch origin and these were dissected along their entire cervical course...
May 25, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28541191/fast-numerical-simulation-of-focused-ultrasound-treatments-during-respiratory-motion-with-discontinuous-motion-boundaries
#7
Michael Schwenke, Joachim Georgii, Tobias Preusser
OBJECTIVE: Focused ultrasound (FUS) is rapidly gaining clinical acceptance for several target tissues in the human body. Yet, treating liver targets is not clinically applied due to a high complexity of the procedure (noninvasiveness, target motion, complex anatomy, blood cooling effects, shielding by ribs, and limited image-based monitoring). To reduce the complexity, numerical FUS simulations can be utilized for both treatment planning and execution. These use-cases demand highly accurate and computationally efficient simulations...
July 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28538555/the-anatomy-of-the-facial-vein-implications-for-plastic-reconstructive-and-aesthetic-procedures
#8
Sebastian Cotofana, Hanno Steinke, Alexander Schlattau, Markus Schlager, Jonathan M Sykes, Malcolm Z Roth, Alexander Gaggl, Riccardo E Giunta, Robert H Gotkin, Thilo L Schenck
BACKGROUND: Anatomical knowledge of the facial vasculature is crucial for successful plastic, reconstructive, and minimally invasive procedures of the face. Whereas the majority of previous investigations focused on facial arteries, the precise course, variability, and relationship with adjacent structures of the facial vein have been widely neglected. METHODS: Seventy-two fresh frozen human cephalic cadavers (32 male and 40 female cadavers; mean age, 75.2 ± 10...
June 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28535851/dancers-perceived-and-actual-knowledge-of-anatomy
#9
Dana H Kotler, Meaghan Lynch, Daniel Cushman, Jason Hu, Jocelyn Garner
Dancers are highly susceptible to musculoskeletal injuries and frequently require interaction with medical professionals. While many dancers have a finely tuned awareness of their bodies, their knowledge of the fundamentals of human anatomy is not uniform. There is a paucity of literature on the benefits of human anatomy education in dancers, though it seems intuitive that there should be a relationship. The purpose of this study was to assess dancers' perceived and actual knowledge of basic musculoskeletal anatomy and its relationship to function...
June 15, 2017: Journal of Dance Medicine & Science
https://www.readbyqxmd.com/read/28527481/rethinking-anatomy-how-to-overcome-challenges-of-medical-education-s-evolution
#10
REVIEW
Bruno Guimarães, Luís Dourado, Stanislav Tsisar, José Miguel Diniz, Maria Dulce Madeira, Maria Amélia Ferreira
INTRODUCTION: Due to scientific and technological development, Medical Education has been readjusting its focus and strategies. Medical curriculum has been adopting a vertical integration model, in which basic and clinical sciences coexist during medical instruction. This context favours the introduction of new complementary technology-based pedagogical approaches. Thus, even traditional core sciences of medical curriculum, like Anatomy, are refocusing their teaching/learning paradigm...
February 27, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28504201/cilia-the-sensory-antennae-in-the-eye
#11
REVIEW
Helen May-Simera, Kerstin Nagel-Wolfrum, Uwe Wolfrum
Cilia are hair-like projections found on almost all cells in the human body. Originally believed to function merely in motility, the function of solitary non-motile (primary) cilia was long overlooked. Recent research has demonstrated that primary cilia function as signalling hubs that sense environmental cues and are pivotal for organ development and function, tissue hoemoestasis, and maintenance of human health. Cilia share a common anatomy and their diverse functional features are achieved by evolutionarily conserved functional modules, organized into sub-compartments...
May 11, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28500091/forensic-age-estimation-using-the-medial-clavicular-epiphysis-a-study-review
#12
Mary B Buckley, Kevin R Clark
PURPOSE: To discuss current literature evaluating the medial clavicular epiphysis to assess an individual's age using various imaging modalities. METHODS: Four scholarly research databases were searched to find studies that examined living subjects. Several articles were included that used cadavers, and a textbook was used to detail the anatomy of the clavicle. Thirty-nine articles were analyzed. RESULTS: The literature indicated that several imaging modalities, including conventional radiography, computed tomography, magnetic resonance, and sonography, are being used to evaluate the medial clavicular epiphysis to estimate an individual's age in the forensic context...
May 2017: Radiologic Technology
https://www.readbyqxmd.com/read/28484627/the-chinchilla-as-a-novel-animal-model-of-pregnancy
#13
Emmeli Mikkelsen, Henrik Lauridsen, Per Mose Nielsen, Haiyun Qi, Thomas Nørlinger, Maria Dahl Andersen, Niels Uldbjerg, Christoffer Laustsen, Puk Sandager, Michael Pedersen
Several parameters are important when choosing the most appropriate animal to model human obstetrics, including gestation period, number of fetuses per gestation and placental structure. The domesticated long-tailed chinchilla (Chinchilla lanigera) is a well-suited and appropriate animal model of pregnancy that often will carry only one offspring and has a long gestation period of 105-115 days. Furthermore, the chinchilla placenta is of the haemomonochorial labyrinthine type and is therefore comparable to the human villous haemomonochorial placenta...
April 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28466514/challenges-in-identifying-and-interpreting-organizational-modules-in-morphology
#14
Borja Esteve-Altava
Form is a rich concept that agglutinates information about the proportions and topological arrangement of body parts. Modularity is readily measurable in both features, the variation of proportions (variational modules) and the organization of topology (organizational modules). The study of variational modularity and of organizational modularity faces similar challenges regarding the identification of meaningful modules and the validation of generative processes; however, most studies in morphology focus solely on variational modularity, while organizational modularity is much less understood...
May 2, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28444223/gene-organizer-linking-genes-to-the-organs-they-affect
#15
David Gokhman, Guy Kelman, Adir Amartely, Guy Gershon, Shira Tsur, Liran Carmel
One of the biggest challenges in studying how genes work is understanding their effect on the physiology and anatomy of the body. Existing tools try to address this using indirect features, such as expression levels and biochemical pathways. Here, we present Gene ORGANizer (geneorganizer.huji.ac.il), a phenotype-based tool that directly links human genes to the body parts they affect. It is built upon an exhaustive curated database that links >7000 genes to ∼150 anatomical parts using >150 000 gene-organ associations...
April 21, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28413859/meniscus-articular-cartilage-and-nucleus-pulposus-a-comparative-review-of-cartilage-like-tissues-in-anatomy-development-and-function
#16
REVIEW
Song Chen, Peiliang Fu, Haishan Wu, Ming Pei
The degradation of cartilage in the human body is impacted by aging, disease, genetic predisposition and continued insults resulting from daily activity. The burden of cartilage defects (osteoarthritis, rheumatoid arthritis, intervertebral disc damage, knee replacement surgeries, etc.) is daunting in light of substantial economic and social stresses. This review strives to broaden the scope of regenerative medicine and tissue engineering approaches used for cartilage repair by comparing and contrasting the anatomical and functional nature of the meniscus, articular cartilage (AC) and nucleus pulposus (NP)...
April 17, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28400207/the-safety-and-efficacy-of-growth-hormone-secretagogues
#17
REVIEW
John T Sigalos, Alexander W Pastuszak
INTRODUCTION: Growth hormone (GH) increases lean body mass, decreases fat mass, increases exercise tolerance and maximum oxygen uptake, enhances muscle strength, and improves linear growth. Long-term studies of GH administration offer conflicting results on its safety, which has led to strict Food and Drug Administration criteria for GH use. The potential drawbacks of exogenous GH use are believed to be due in part to impaired regulatory feedback. AIM: To review the literature on GH secretagogues (GHSs), which include GH-releasing peptides and the orally available small-molecule drug ibutamoren mesylate...
April 8, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28377682/body-of-evidence-integrating-eduard-pernkopf-s-atlas-into-a-librarian-led-medical-humanities-seminar
#18
Keith C Mages, Linda A Lohr
BACKGROUND: Anatomical subjects depicted in Eduard Pernkopf's richly illustrated Topographische Anatomie des Menschen may be victims of the Nazi regime. Special collections librarians in the history of medicine can use this primary resource to initiate dialogs about ethics with medical students. CASE PRESENTATION: Reported here is the authors' use of Pernkopf's Atlas in an interactive medical humanities seminar designed for third-year medical students. Topical articles, illustrations, and interviews introduced students to Pernkopf, his Atlas, and the surrounding controversies...
April 2017: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/28362409/intraductal-delivery-to-the-rabbit-mammary-gland
#19
Amelia Clark, Nora K Bird, Amy Brock
Localized intraductal treatments for breast cancer offer potential advantages, including efficient delivery to the tumor and reduced systemic toxicity and adverse effects(1)(,)(2)(,)(3)(,)(4)(,)(5)(,)(6)(,)(7). However, several challenges remain before these treatments can be applied more widely. The development and validation of intraductal therapeutics in an appropriate animal model facilitate the development of intraductal therapeutic strategies for patients. While the mouse mammary gland has been widely used as a model system of mammary development and tumorigenesis, the anatomy is distinct from the human gland...
March 9, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28340659/exploring-new-frontiers-of-microsurgery-from-anatomy-to-clinical-methods
#20
REVIEW
Zeng Tao Wang, You Mao Zheng, Lei Zhu, Li Wen Hao, Ya Bin Zhang, Chao Chen, Li Feng Xia, Lin Feng Liu
This article presents the authors' understanding and experience concerning anatomic studies and clinical methods in microsurgical hand reconstruction. The 4 parts of this article include anatomic study of the hand for developing new flaps; application of miniflaps from the hand, including clinical experience with 8 unique flaps in the hand; anatomic and clinical considerations concerning several flaps from other parts of the human body; And our experience with vascularized free toe joint transfer.
April 2017: Clinics in Plastic Surgery
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