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Candida parapsilosis treatment in neonate

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https://www.readbyqxmd.com/read/27603544/portal-vein-thrombosis-in-a-preterm-newborn-with-mutation-of-the-mthfr-and-pai-1-genes-and-sepsis-by-candida-parapsilosis
#1
Mario Giuffrè, Clelia Lo Verso, Gregorio Serra, Giovanni Moceri, Marcello Cimador, Giovanni Corsello
Objective This report discusses the role of both congenital and acquired risk factors in the pathogenesis of portal vein thrombosis (PVT). Study Design We describe the clinical management and treatment of PVT in a preterm newborn with a homozygous mutation of the methylenetetrahydrofolate reductase (MTHFR) and plasminogen activator inhibitor-1 (PAI-1) genes and sepsis by Candida parapsilosis. Results Although literature data suggest a minor role of genetic factors in thrombophilia in the case of only one mutation, we hypothesize that combined thrombophilic genetic defects may have a cumulative effect and significantly increase the thrombotic risk...
September 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27479764/epidemiology-of-candidemia-in-neonatal-intensive-care-units-a-persistent-public-health-problem
#2
G Lovero, O De Giglio, O Montagna, G Diella, F Divenuto, M Lopuzzo, S Rutigliano, N Laforgia, G Caggiano, M T Montagna
BACKGROUND: Candidemia has become an increasingly important problem in infants hospitalized in the Neonatal Intensive Care Units (NICUs). Candida species are the third most common agents of late-onset infections in critically ill neonates and they are associated with high morbidity and mortality rates. In this study we evaluated the epidemiology of Candida bloodstream infections in the NICU of an Italian university hospital during a 15-year period. Our specific aims were to analyze the change in species distribution and the vitro susceptibility of these yeasts to fluconazole (FCZ) and amphotericin B (AmB)...
July 2016: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/27364939/-fungal-colonization-in-preterm-neonates-weighing-less-than-1500g-admitted-to-the-neonatal-intensive-care-unit
#3
M D Benjamin, E Jolivet, N Desbois, J Pignol, S Ketterer-Martinon, L Pierre-Louis, O Flechelles
Fungal colonization is a common occurrence in preterm neonates. Our objective was to describe the profile and characteristics of fungal colonization in preterm infants admitted to the Martinique NICU. From March 2012 to January 2013, an epidemiological prospective cohort study was conducted with 57 very low-birth-weight infants. Cutaneous, rectal, gastric, respiratory, and urinary swabs were collected on admission, then every week for 4 weeks. The prevalence of fungal colonization was 68% (39/57): 46% by Malassezia species, 28% by Candida parapsilosis, 19% by C...
September 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27067876/-current-aspects-of-invasive-diseases-caused-by-candida-and-other-yeast-fungi
#4
Javier Pemán, Guillermo Quindós
Invasive candidiasis is the most common invasive fungal disease causing an unacceptably high mortality. Candida albicans remains the predominant origin, but an epidemiological shift has been described in the last decades. Some species of Candida have emerged as an important cause of severe candidaemia and can exhibit reduced susceptibility to the current antifungal agents. Candida parapsilosis has been associated with candidaemia in neonates and young adults, whereas Candida glabrata, Candida tropicalis, and Candida krusei are most frequently isolated in blood cultures from older patients (>65 years)...
July 2016: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/26439426/-first-report-of-invasive-fungal-disease-by-candida-fabianii-in-a-non-neonatal-paediatric-patient
#5
Jose Carlos Flores-González, Inmaculada Guerrero-Lozano, Juan Jesús Pérez-Guerrero, Arturo Hernández-González, Fátima Galán-Sánchez, Sebastián Quintero-Otero, Fernando Rubio-Quiñones, Servando Pantoja-Rosso
BACKGROUND: Invasive fungal diseases have increased in recent years. Candida species are the most common aetiology. Candida albicans, Candida parapsilosis, Candida tropicalis, Candida glabrata and Candida krusei are the cause of most of them. The aim of this work is to describe the first isolation of Candida fabianii in the blood of a non-neonatal paediatric patient. CASE REPORT: A 2 year-old male with short bowel syndrome, severe malnutrition, and hypophosphataemic rickets deficiency was admitted to paediatric intensive care due to a respiratory tract infection and suspicion of an intestinal pseudo-obstruction...
January 2016: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/26146582/successful-treatment-of-candida-parapsilosis-fungemia-in-two-preterms-with-voriconazole
#6
Emel Altuncu, Hulya Bilgen, Ahmet Soysal, Eren Ozek
Herein, we report two preterms with invasive candidiasis refractory to liposomal amphotericin B (AMB) treatment in spite of low MIC levels (MIC: 0.5 mcg/mL). Both of the patients' blood cultures were persistently positive for C. parapsilosis despite high therapeutic doses (AMB: 7 mg/kg per day). After starting voriconazole blood cultures became negative and both of the patients were treated successfully without any side effects. In conclusion, although it is not a standard treatment in neonatal patients, our limited experience with these patients suggests that voriconazole appears to be a safe antifungal agent to be used in critically ill preterm infants with persistent fungemia despite AMB treatment...
2015: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/25666389/neonatal-candidemia-caused-by-candida-haemulonii-case-report-and-review-of-literature
#7
REVIEW
Carolina M Silva, Ana M R Carvalho-Parahym, Danielle P C Macêdo, Reginaldo G Lima-Neto, Elaine C Francisco, Analy S A Melo, Maria da Conceição M Silva, Moacir B Jucá, Luciana R B Mello, Rosemary M J Amorim, Rejane P Neves
Candidemia is a frequent condition in Neonatal Intensive Care Units (NICU) and usually complicates the newborns clinical course. Several factors are responsible for candidiasis, such as prematurity and use of broad-spectrum antibiotics, and in these cases, there are the involvement of various Candida species, as C. albicans, and C. parapsilosis. However, other species as C. haemulonii has been rarely described in candidemia cases, being considered an emergent pathogen. Thus, we report a case of neonatal candidemia by C...
August 2015: Mycopathologia
https://www.readbyqxmd.com/read/25365503/invasive-fungal-infection-in-neonatal-intensive-care-units-a-multicenter-survey
#8
Monica Isabel Baptista, José Nona, Marta Ferreira, Isabel Sampaio, Margarida Abrantes, Maria Teresa Tomé, Maria Teresa Neto, Rosalina Barroso, Micaella Serelha, Daniel Virella
This study assesses the epidemiology of invasive fungal infection (IFI) in Portuguese Neonatal Intensive Care Units (NICUs) and compares the effectiveness and safety of antifungal therapies. A survey concerning the period 2005-2010 was carried out in NICUs of Greater Lisbon. Among 10 473 admitted neonates, 44 cases were identified, 29 among extreme low birth weight neonates (65.9%). Cumulative incidence rate was 0.42% (95%CI 0.309-0.559). A central vascular catheter was present before IFI in all cases. Candida albicans and Candida parapsilosis were the most frequent isolates...
2016: Journal of Chemotherapy
https://www.readbyqxmd.com/read/24983550/-colonization-by-candida-in-a-neonatal-intensive-care-unit
#9
Amilcar Caballero-Trejo, Carlos Eduardo Aguirre-Morales, Gloria M González-González, Dzoara Cortés-Palma, María Guadalupe Miranda-Novales
BACKGROUND: Candida infections have increased in the last few decades. Previous colonization is the most important risk factor for the development of fungemia. Understanding local epidemiology is necessary in order to select the optimal anti-fungal treatment. The purpose of this study was to establish colonization by Candida in patients, staff and medical devices in a neonatal intensive care unit. METHODS: A prospective cohort study was conducted. Cultures were obtained from different anatomic sites, from medical devices and from the hands of healthcare staff at admission and every 7 days until discharge of the unit...
2014: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/24919490/systemic-candidiasis-in-extremely-low-birthweight-elbw-neonates-despite-the-routine-use-of-topical-miconazole-prophylaxis-trends-risk-factors-and-outcomes-over-an-11-year-period
#10
Bhavani Sriram, Pratibha K Agarwal, Nancy W S Tee, Victor S Rajadurai
INTRODUCTION: This study aims to determine the incidence, trends of systemic candidiasis and meningitis in extremely low birthweight (ELBW) neonates (<1000 gms) despite the routine use of topical miconazole prophylaxis and to compare the risk factors, adverse outcomes and comorbidities with controls. MATERIALS AND METHODS: Retrospective cohort study of ELBW neonates with systemic candidiasis and meningitis over an 11-year period (1997 to 2007). Matched case control analyses were performed to determine the risk factors and comorbidities which were severe intraventricular haemorrhage (IVH), severe retinopathy of prematurity (ROP), patent ductus arteriosus (PDA) requiring treatment, necrotising enterocolitis (NEC), chronic lung disease (CLD) and cholestatic jaundice...
May 2014: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/24567311/successful-treatment-of-an-infant-infected-with-refractory-c-parapsilosis-with-caspofungin
#11
Aslınur Ozkaya-Parlakay, Hasan Tezer, Tugba Kazmacan, Belgin Gulhan, Sevim Unal
Neonatal Candida infections are the leading cause of invasive fungal infections that might cause severe morbidity or mortality in a large majority of those affected. Although Candida albicans has been the most common species, Candida parapsilosis is increasingly being recognized as an important cause of invasive candidiasis in neonates. Among the Candida species, C. parapsilosis has been commonly isolated and shown to be less susceptible in vitro to echinocandins than other Candida species. We report an infant who had refractory C...
August 2014: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/24270071/epidemiology-of-candidaemia-and-invasive-candidiasis-a-changing-face
#12
REVIEW
Guillermo Quindós
Invasive candidiasis is a leading cause of mortality. Candidaemia is the most common clinical presentation of invasive candidiasis but more that 30% of these infections do not yield positive blood cultures. Candida albicans remains the predominant aetiology, accounting for 50% of all cases. However, there has been an epidemiological shift in the last decades. Some species of Candida different to C. albicans have emerged as an important cause of severe candidaemia as they can exhibit resistance to fluconazole and other antifungal agents...
January 2014: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/23803724/background-changing-patterns-of-neonatal-fungal-sepsis-in-a-developing-country
#13
REVIEW
Daynia E Ballot, Noma Bosman, Trusha Nana, Tanisha Ramdin, Peter A Cooper
BACKGROUND: Candida albicans is the predominant isolate in many neonatal fungal bloodstream infections (BSIs), so fluconazole is used as empiric antifungal therapy. AIM: To determine the predominant organisms, antifungal sensitivity patterns, clinical and demographic risk factors and crude mortality rate in neonatal fungal BSI cases. SUBJECTS AND METHODS: This is a review of all neonatal fungal BSI cases between January 2007 and December 2011...
December 2013: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/23279221/the-role-of-galectin-3-in-phagocytosis-of-candida-albicans-and-candida-parapsilosis-by-human-neutrophils
#14
Jennifer R Linden, Dennis Kunkel, Sonia S Laforce-Nesbitt, Joseph M Bliss
Candida albicans causes the majority of invasive candidiasis in immunocompromised adults while Candida parapsilosis is a leading cause of neonatal candidiasis. While much work has focused on how the immune system recognizes and responds to C. albicans, less is known about host interaction with C. parapsilosis. This study investigates the human neutrophil phagocytic response to these species. Neutrophils underwent phagocytosis of C. parapsilosis yeast and C. albicans hyphae much more efficiently than C...
July 2013: Cellular Microbiology
https://www.readbyqxmd.com/read/23166173/fungal-myocarditis-in-a-preterm-neonate
#15
Michael Harris, Srinivas Ananth Narayan, Elizabeth Ann Orchard
A male infant born at 25 weeks gestation presented with abdominal distension, was transferred to our institution for surgical management following suspected bowel perforation with severe sepsis. Umbilical catheter cultures grew Candida parapsilosis. At laparotomy, there was a large ileal perforation with peritonitis, he was treated with amphotericin, antibiotics and had an ileostomy. He had persistent pulmonary hypertension, requiring nitric oxide and high-frequency oscillatory ventilation. Serial echocardiograms revealed a patent ductus arteriosus (PDA), but also demonstrated increasing left ventricular hypertrophy and the development of bright areas within the septal myocardium...
2012: BMJ Case Reports
https://www.readbyqxmd.com/read/23102556/epidemiology-and-outcomes-of-candidemia-in-3648-patients-data-from-the-prospective-antifungal-therapy-path-alliance%C3%A2-registry-2004-2008
#16
REVIEW
Michael Pfaller, Dionissios Neofytos, Daniel Diekema, Nkechi Azie, Herwig-Ulf Meier-Kriesche, Shun-Ping Quan, David Horn
This analysis describes the epidemiology and outcomes of candidemia in patients enrolled in the Prospective Antifungal Therapy Alliance (PATH Alliance®) registry from 2004 to 2008. Overall, 4067 Candida isolates were identified from 3648 patients. The most common Candida spp. were C. albicans (42.1%), C. glabrata (26.7%), C. parapsilosis (15.9%), C. tropicalis (8.7%), and C. krusei (3.4%). The proportion of candidemia caused by non-albicans Candida spp. (57.9%) was higher than that caused by C. albicans (42...
December 2012: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/22982980/results-from-a-prospective-international-epidemiologic-study-of-invasive-candidiasis-in-children-and-neonates
#17
MULTICENTER STUDY
William J Steinbach, Emmanuel Roilides, David Berman, Jill A Hoffman, Andreas H Groll, Ibrahim Bin-Hussain, Debra L Palazzi, Elio Castagnola, Natasha Halasa, Aristea Velegraki, Christopher C Dvorak, Arunaloke Charkabarti, Lillian Sung, Lara Danziger-Isakov, Catherine Lachenauer, Antonio Arrieta, Katherine Knapp, Mark J Abzug, Christine Ziebold, Thomas Lehrnbecher, Lena Klingspor, Adilia Warris, Kateri Leckerman, Teresa Martling, Thomas J Walsh, Daniel K Benjamin, Theoklis E Zaoutis
BACKGROUND: Candida species are the third most common cause of pediatric health care-associated bloodstream infection in the United States and Europe. To our knowledge, this report from the International Pediatric Fungal Network is the largest prospective, multicenter observational study dedicated to pediatric and neonatal invasive candidiasis. METHODS: From 2007 to 2011, we enrolled 196 pediatric and 25 neonatal patients with invasive candidiasis. RESULTS: Non-albicans Candida species predominated in pediatric (56%) and neonatal (52%) age groups, yet Candida albicans was the most common species in both groups...
December 2012: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/22869093/candida-parapsilosis-candidaemia-in-a-neonatal-unit-over-7-years-a-case-series-study
#18
Lourdes das Neves Miranda, Eliete C A Rodrigues, Silvia F Costa, Inneke Marie van der Heijden, Kátia C Dantas, Renata D Lobo, Mariusa Basso, Gláucia F Varkulja, Vera Lúcia Jornada Krebs, Maria Augusta Bento Cicaroni Gibelli, Paulo R Criado, Anna Sara Levin
OBJECTIVE: To evaluate Candida parapsilosis candidaemia in a neonatal unit over 7 years. DESIGN: Case series study. SETTING: A 2000-bed tertiary-care university hospital at São Paulo, Brazil. PARTICIPANTS: Neonates hospitalised in a 63-bed neonatal unit. PRIMARY AND SECONDARY OUTCOME MEASURES: We evaluated the incidence of C parapsilosis fungemia in a neonatal unit from 2002 through 2008 and the main microbiological, clinical and epidemiological aspects of this disease in neonates...
2012: BMJ Open
https://www.readbyqxmd.com/read/22448706/neonatal-invasive-candidiasis-in-tunisian-hospital-incidence-risk-factors-distribution-of-species-and-antifungal-susceptibility
#19
J Ben Abdeljelil, F Saghrouni, S Nouri, S Geith, I Khammari, A Fathallah, H Sboui, M Ben Saïd
The aim of our study was to assess epidemiological features of neonatal invasive candidiasis in Farhat Hached hospital of Sousse, Tunisia, including incidence, risk factors, mortality, species distribution and antifungal susceptibility. Laboratory data from 1995 to 2010 and medical records of 127 invasive candidiasis cases were reviewed. We tested the susceptibility of 100 Candida sp isolates by using ATB fungus(®) 3 and to fluconazole by using E-test(®) strips. A total of 252 cases of neonatal invasive candidiasis occurred over the study period...
November 2012: Mycoses
https://www.readbyqxmd.com/read/22320707/neonatal-candidiasis-results-of-an-8-year-study
#20
Solmaz Celebi, Mustafa Hacimustafaoglu, Nilgun Koksal, Hilal Ozkan, Merih Cetinkaya, Beyza Ener
BACKGROUND: The aim of the present study was to evaluate the risk factors, demographic features, treatment and clinical outcome associated with candidemia in a neonatal intensive care unit (NICU) within an 8 year period. METHODS: The data of infants who were diagnosed as having candidemia, were evaluated. RESULTS: Between January 2000 and December 2007, a total of 28 candidemia episodes were identified in 28 infants. A 1.1% candidemia incidence was documented in the neonatal intensive care unit (NICU)...
June 2012: Pediatrics International: Official Journal of the Japan Pediatric Society
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