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https://www.readbyqxmd.com/read/28103632/global-health-and-emergency-care-defining-clinical-research-priorities
#1
Bhakti Hansoti, Adam R Aluisio, Meagan A Barry, Kevin Davey, Brian A Lentz, Payal Modi, Jennifer A Newberry, Melissa H Patel, Tricia A Smith, Alexandra M Vinograd, Adam C Levine
OBJECTIVES: Despite recent strides in the development of Global Emergency Medicine (EM), the field continues to lag in applying a scientific approach to identifying critical knowledge gaps and advancing evidence-based solutions to clinical and public health problems seen in emergency departments worldwide. Here, progress on the Global EM research agenda created at the 2013 Academic Emergency Medicine Global Health and Emergency Care Consensus Conference is evaluated and critical areas for future development in emergency care research internationally are identified...
January 19, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28103581/diagnostic-and-prognostic-utilities-of-humoral-fibulin-3-in-malignant-pleural-mesothelioma-evidence-from-a-meta-analysis
#2
Dongxu Pei, Yongwei Li, Xinwei Liu, Sha Yan, Xiaolan Guo, Xiaona Xu, Xiaoxia Guo
Fibulin-3 has emerged as a promising novel biomarker in conforming or monitoring malignant pleural mesothelioma (MPM). This study sought to evaluate the diagnostic and prognostic efficacies of humoral fibulin-3 for MPM. Seven eligible publications comprising 468 MPM cases for diagnosis, and 138 for prognosis were identified. Results manifested that humoral fibulin-3 sustained a pooled sensitivity of 0.62 (95% CI: 0.45-0.77) and specificity of 0.82 (95% CI: 0.73-0.89) in discriminating MPM patients from cancer-free individuals, corresponding to an AUC (area under the curve) of 0...
January 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28103559/exploring-the-missing-links-between-dietary-habits-and-diseases
#3
Malay Bhattacharyya, Soumi Maity, Sanghamitra Bandyopadhyay
Disease dietomics is an emerging area of systems biology that attempts to explore the connections between the dietary habits and diseases. Some of the topical studies highlight that foods might have different impacts over an organism either in progressing a disease (negative association) or in fighting against it (positive association). The association of foods with different diseases can be put together to build a network that might provide a global view of the entire system. Again, such disease-food networks might emerge in a more complex form while considering the disease subtypes individually...
January 16, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28103548/dimensionality-reduction-on-spd-manifolds-the-emergence-of-geometry-aware-methods
#4
Mehrtash Harandi, Mathieu Salzmann, Richard Hartley
Representing images and videos with Symmetric Positive Definite (SPD) matrices, and considering the Riemannian geometry of the resulting space, has been shown to yield high discriminative power in many visual recognition tasks. Unfortunately, computation on the Riemannian manifold of SPD matrices -especially of high-dimensional ones- comes at a high cost that limits the applicability of existing techniques. In this paper, we introduce algorithms able to handle high-dimensional SPD matrices by constructing a lower-dimensional SPD manifold...
January 18, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28103530/an-anti-oxidant-%C3%AE-lipoic-acid-conjugated-oleoyl-sn-phosphatidylcholineas-a-helper-lipid-in-cationic-liposomal-formulations
#5
Priya Dharmalingam, Balakrishna Marrapu, Chandrashekhar Voshavar, Rasagna Nadella, Vignesh Kumar Rangasami, R V Shaji, Salar Abbas, R B N Prasad, Shiva Shanker Kaki, Srujan Marepally
Development of safe non-viral carrier systems for efficient intra-cellular delivery of drugs and genes hold promise in the area of translational research. Liposome based delivery systems have emerged as one of the attractive strategies for efficient delivery of drugs and nucleic acids. To this end, number of investigations was carried on liposomal formulations using lipids for achieving higher efficiency in transfection with lower cytotoxicities. In our efforts to develop safer and efficient liposomal delivery systems, we synthesized a novel anti-oxidant lipid, α-lipoyl, oleyl-sn-phosphatidylcholine (LOPC) and used as a helper lipid in combination with a cationic amphiphile, Di-Stearyl Dihydroxy Ethyl Ammonium Chloride (DSDEAC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) at varying concentrations of LOPC...
January 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28103525/micrornas-in-ectodermal-appendages
#6
REVIEW
D'Juan T Farmer, Michael T McManus
The surface ectoderm is the source of ectodermal appendages including hair, teeth, and many glands. The development and function of ectodermal appendages has been researched extensively, but many of the molecular mechanisms that govern the developmental programs of ectodermal appendages remain elusive. While several protein-coding genes are established as key regulators of ectodermal appendage development, the role of noncoding RNAs is an emerging area of investigation. This review highlights recent advances in studies of microRNA-mediated control of ectodermal appendage development using mouse models...
January 16, 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/28103513/interventional-radiology-in-the-management-of-thoracic-duct-injuries-anatomy-techniques-and-results
#7
REVIEW
Mohammad Toliyat, Kanwar Singh, Robert C Sibley, Murthy Chamarthy, Sanjeeva P Kalva, Anil K Pillai
Disruption of the thoracic duct can have devastating consequences and be associated with a high morbidity and mortality. Conservative therapies have been attempted to treat chylothorax without much success. Surgical management has traditionally been necessary to provide definitive treatment at the expense of increased morbidity. Lymphatic interventions have recently emerged as a new frontier for interventional radiologists to add value and provide minimally invasive therapies for debilitating conditions. The goal of this manuscript is to review the anatomy of the thoracic duct, describe various percutaneous techniques for accessing the duct, and briefly discuss outcomes as reported in the literature...
January 3, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28103497/host-microbiota-interactions-epigenomic-regulation
#8
REVIEW
Vivienne Woo, Theresa Alenghat
The coevolution of mammalian hosts and their commensal microbiota has led to the development of complex symbiotic relationships between resident microbes and mammalian cells. Epigenomic modifications enable host cells to alter gene expression without modifying the genetic code, and therefore represent potent mechanisms by which mammalian cells can transcriptionally respond, transiently or stably, to environmental cues. Advances in genome-wide approaches are accelerating our appreciation of microbial influences on host physiology, and increasing evidence highlights that epigenomics represent a level of regulation by which the host integrates and responds to microbial signals...
January 16, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28103496/toddlers-action-prediction-statistical-learning-of-continuous-action-sequences
#9
Claire D Monroy, Sarah A Gerson, Sabine Hunnius
The current eye-tracking study investigated whether toddlers use statistical information to make anticipatory eye movements while observing continuous action sequences. In two conditions, 19-month-old participants watched either a person performing an action sequence (Agent condition) or a self-propelled visual event sequence (Ghost condition). Both sequences featured a statistical structure in which certain action pairs occurred with deterministic transitional probabilities. Toddlers learned the transitional probabilities between the action steps of the deterministic action pairs and made predictive fixations to the location of the next action in the Agent condition but not in the Ghost condition...
January 16, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28103487/a-turn-on-thiol-functionalized-fluorescent-carbon-quantum-dot-based-chemosensory-system-for-arsenite-detection
#10
Pooja D, Sonia Saini, Anupma Thakur, Baban Kumar, Sachin Tyagi, Manoj K Nayak
Carbon quantum dots (CQDs) have emerged out as promising fluorescent probes for hazardous heavy metals detection in recent past. In this study, water soluble CQDs were synthesized by facile microwave pyrolysis of citric acid & cysteamine, and functionalized with ditheritheritol to impart thiol functionalities at surface for selective detection of toxic arsenite in water. Microscopic analysis reveals that the synthesized CQDs are of uniform size (diameter ∼5nm) and confirmed to have surface SH groups by FT-IR...
January 12, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28103469/transitions-of-postural-coordination-as-a-function-of-frequency-of-the-moving-support-platform
#11
Aviroop Dutt-Mazumder, Karl Newell
This study was set-up to investigate the multi-segmental organization of human postural control in a dynamic balance task. The focus was on the coupling between the center of mass (CoM) and center of pressure (CoP) as a candidate collective variable that supports maintaining balance on a sinusoidal oscillating platform in the medial-lateral (ML) plane and was continuously scaled up and then down across a frequency range from 0.2Hz to 1.2Hz. The CoM-CoP coordination changed from in-phase to anti-phase and anti-phase to in-phase at a critical frequency (∼0...
January 16, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28103463/-uterine-rupture-at-18-weeks-of-pregnancy-in-the-context-of-malformed-uterus
#12
Emídio Vale-Fernandes, Neusa Teixeira, Alexandra Cadilhe, Maria José Rocha
Birth defects of the female genital tract are relatively common and often asymptomatic. Despite the pregnancy outcome can be favorable, adverse obstetric outcomes are described in women with uterine malformations. The authors report the case of an obstetric emergency which enhances the possibility of a very adverse and rare outcome of uterine rupture in a left hemi-cavity of a bicornuate uterus away from the term, at 18 weeks of pregnancy, in a pregnant woman with history of caesarean in the right hemi-cavity and with placenta increta...
October 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28103426/analytical-characterization-and-pharmacological-evaluation-of-the-new-psychoactive-substance-4-fluoromethylphenidate-4%C3%A2-f-mph-and-differentiation-between-the-%C3%A2-threo-and-%C3%A2-erythro-diastereomers
#13
Gavin McLaughlin, Noreen Morris, Pierce V Kavanagh, John D Power, Geraldine Dowling, Brendan Twamley, John O'Brien, Gary Hessman, Brian Murphy, Donna Walther, John S Partilla, Michael H Baumann, Simon D Brandt
Misuse of (±)-threo-methylphenidate (methyl-2-phenyl-2-(piperidin-2-yl)acetate; Ritalin®, MPH) has long been acknowledged, but the appearance of MPH analogs in the form of 'research chemicals' has only emerged in more recent years. 4-Fluoromethylphenidate (4 F-MPH) is one of these recent examples and this study presents the identification and analytical characterization of two powdered 4 F-MPH products that were obtained from an online vendor in 2015. Interestingly, the products appeared to have originated from two distinct batches given that one product consisted of (±)-threo-4 F-MPH isomers whereas the second sample consisted of a mixture of (±)-threo and (±)-erythro 4 F-MPH...
January 19, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28103419/family-presence-during-resuscitation-a-double-edged-sword
#14
Hadi Hassankhani, Vahid Zamanzadeh, Azad Rahmani, Hamidreza Haririan, Joanne E Porter
PURPOSE: To illuminate the meaning of the lived experiences of resuscitation team members with the presence of the patient's family during resuscitation in the cultural context of Iran. DESIGN: An interpretative phenomenology was used to discover the lived experiences of the nurses and physicians of Tabriz hospitals, Iran, with family presence during resuscitation (FPDR). A total of 12 nurses and 9 physicians were interviewed over a 6-month period. METHODS: The interviews were audio recorded and semistructured, and were transcribed verbatim...
January 19, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28103342/failed-tracheal-intubation-in-a-child-with-unrecognized-hunter-s-syndrome-having-emergency-surgery
#15
F Meng, Y Li, G Wang, Q Wang
No abstract text is available yet for this article.
July 7, 2016: West Indian Medical Journal
https://www.readbyqxmd.com/read/28103317/genetically-thermo-stabilised-immunogenic-poliovirus-empty-capsids-a-strategy-for-non-replicating-vaccines
#16
Helen Fox, Sarah Knowlson, Philip D Minor, Andrew J Macadam
While wild type polio has been nearly eradicated there will be a need to continue immunisation programmes for some time because of the possibility of re-emergence and the existence of long term excreters of poliovirus. All vaccines in current use depend on growth of virus and most of the non-replicating (inactivated) vaccines involve wild type viruses known to cause poliomyelitis. The attenuated vaccine strains involved in the eradication programme have been used to develop new inactivated vaccines as production is thought safer...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28103241/contextual-refinement-of-regulatory-targets-reveals-effects-on-breast-cancer-prognosis-of-the-regulome
#17
Erik Andrews, Yue Wang, Tian Xia, Wenqing Cheng, Chao Cheng
Gene expression regulators, such as transcription factors (TFs) and microRNAs (miRNAs), have varying regulatory targets based on the tissue and physiological state (context) within which they are expressed. While the emergence of regulator-characterizing experiments has inferred the target genes of many regulators across many contexts, methods for transferring regulator target genes across contexts are lacking. Further, regulator target gene lists frequently are not curated or have permissive inclusion criteria, impairing their use...
January 19, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28103233/evaluation-of-a-smartphone-decision-support-tool-for-diarrheal-disease-management-in-a-resource-limited-setting
#18
Farhana Haque, Robyn L Ball, Selina Khatun, Mujaddeed Ahmed, Saraswati Kache, Mohammod Jobayer Chisti, Shafiqul Alam Sarker, Stace D Maples, Dane Pieri, Teja Vardhan Korrapati, Clea Sarnquist, Nancy Federspiel, Muhammad Waliur Rahman, Jason R Andrews, Mahmudur Rahman, Eric Jorge Nelson
The emergence of mobile technology offers new opportunities to improve clinical guideline adherence in resource-limited settings. We conducted a clinical pilot study in rural Bangladesh to evaluate the impact of a smartphone adaptation of the World Health Organization (WHO) diarrheal disease management guidelines, including a modality for age-based weight estimation. Software development was guided by end-user input and evaluated in a resource-limited district and sub-district hospital during the fall 2015 cholera season; both hospitals lacked scales which necessitated weight estimation...
January 19, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28103216/erratum-vol-65-suppl-3
#19
(no author information available yet)
In the report "Safe and Effective Deployment of Personnel to Support the Ebola Response-West Africa," which was part of the supplement entitled "CDC's Response to the 2014-2016 Ebola Pandemic-West Africa and United States," the following author was omitted from the listing on the first page: Jacqueline R. Burkholder, PhD, Division of Emergency Operations, Office of Public Health Awareness, CDC.
January 20, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28103211/notes-from-the-field-hantavirus-pulmonary-syndrome-in-a-migrant-farm-worker-colorado-2016
#20
Grace Marx, Kaylan Stinson, Monte Deatrich, Bernadette Albanese
On August 8, 2016, Tri-County Health Department (Adams, Arapahoe, and Douglas counties) in Colorado was notified of a confirmed case of hantavirus pulmonary syndrome (HPS). The patient was a previously healthy male migrant farm worker aged 25 years, living in farm quarters, and working in vegetable fields for 8 weeks before symptom onset. On July 20, he experienced sudden onset of fever, severe headache, myalgias, cough, and nosebleed. He was evaluated at an emergency department on July 23, where his temperature was 103...
January 20, 2017: MMWR. Morbidity and Mortality Weekly Report
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