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chrysin and cancer

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https://www.readbyqxmd.com/read/28166590/the-effect-of-chrysin-loaded-plga-peg-on-metalloproteinase-gene-expression-in-mouse-4t1-tumor-model
#1
Zoheyr Mohammadi, Mohsen Sharif Zak, Khaled Seidi, Meisam Barati, Abolfazl Akbarzadeh, Nosratollah Zarghami
Despite the advances in medicine, cancer remains as one of the leading causes of the death worldwide. Through our previous study, the Chrysin loaded PGLA/PEG has been synthesized, and its physico-chemical properties were characterized. The aim of the present study was to evaluate the Chrysin loaded PGLA/PEG nanoparticle therapeutic effects on TIMP-1, TIMP-2, MMP-2, MMP-9 and PI3k expression in Mouse 4T1 breast tumor model.30 mice were enrolled in the current study, and the mice were randomly divided into 3 groups: untreated (n=10), Chrysin treatment (n=10) and Chrysin-loaded PLGA/PEG-based treatment (n=10)...
February 6, 2017: Drug Research
https://www.readbyqxmd.com/read/28134775/chrysin-protects-rat-kidney-from-paracetamol-induced-oxidative-stress-inflammation-apoptosis-and-autophagy-a-multi-biomarker-approach
#2
Fatih Mehmet Kandemir, Sefa Kucukler, Eyup Eldutar, Cuneyt Caglayan, İlhami Gülçin
Paracetamol (PC) is a safe analgesic and antipyretic drug at therapeutic doses, and it is widely used in clinics. However, at high doses, it can induce hepatotoxicity and nephrotoxicity. Chrysin (CR) is a natural flavonoid that has biological activities that include being an antioxidant, an anti-inflammatory, and an anti-cancer agent. The main objective of this study was to investigate the efficacy of CR against PC-induced nephrotoxicity in rats. CR was given orally via feeding needle to male Sprague Dawley rats as a single daily dose of 25 or 50 mg/kg for six days...
January 26, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28047565/su-g-tep3-10-radiation-induces-prompt-live-cell-metabolic-fluxes
#3
D Campos, W Peeters, K Nickel, B Burkel, J Bussink, R Kimple, A van der Kogel, K Eliceiri, M Kissick
PURPOSE: To compare metabolic dynamics and HIF-1α expression following radiation between a cancerous cell line (UM-SCC-22B) and a normal, immortalized cell line, NOK (Normal Oral Keratinocyte). HIF-1 is a key factor in metabolism and radiosensitivity. A better understanding of how radiation affects the interplay of metabolism and HIF-1 might give a better understanding of the mechanisms responsible for radiosensitivity. METHODS: Changes in cellular metabolism in response to radiation are tracked by fluorescence lifetime of NADH...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27951449/plant-flavonoids-in-cancer-chemoprevention-role-in-genome-stability
#4
REVIEW
Vazhappilly Cijo George, Graham Dellaire, H P Vasantha Rupasinghe
Carcinogenesis is a multistage process that involves a series of events comprising of genetic and epigenetic changes leading to the initiation, promotion and progression of cancer. Chemoprevention is referred to as the use of nontoxic natural compounds, synthetic chemicals or their combinations to intervene in multistage carcinogenesis. Chemoprevention through diet modification, i.e., increased consumption of plant-based food, has emerged as a most promising and potentially cost-effective approach to reducing the risk of cancer...
November 28, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27918469/dietary-compound-chrysin-inhibits-retinal-neovascularization-with-abnormal-capillaries-in-db-db-mice
#5
Min-Kyung Kang, Sin-Hye Park, Yun-Ho Kim, Eun-Jung Lee, Lucia Dwi Antika, Dong Yeon Kim, Yean-Jung Choi, Young-Hee Kang
Diabetic retinopathy (DR) develops in a significant proportion of patients with chronic diabetes, characterized by retinal macular edema and abnormal retinal vessel outgrowth leading to vision loss. Chrysin, a naturally-occurring flavonoid found in herb and honeycomb, has anti-inflammatory, antioxidant, and anti-cancer properties. This study sought to determine the protective effects of chrysin on retinal neovascularization with abnormal vessels and blood-retinal barrier (BRB) breakdown in 33 mM glucose-exposed human retinal endothelial cells and in db/db mouse eyes...
December 3, 2016: Nutrients
https://www.readbyqxmd.com/read/27847208/synthesis-and-characterization-of-chrysin-loaded-pcl-peg-pcl-nanoparticle-and-its-effect-on-breast-cancer-cell-line
#6
Ali Eatemadi, Hadis Daraee, Hammed T Aiyelabegan, Babak Negahdari, Bahram Rajeian, Nosratollah Zarghami
BACKGROUND: Nano-therapy exhibit the potential of revolutionizing cancer therapy. This field introduces nanovectors/nanocarriers for anticancer drugs targeted delivery, and also finds application in imaging. Chrysin, a natural flavonoid, was recently studied as having important biological roles in chemical defenses, nitrogen fixation, anti-inflammatory, and anti-oxidant properties. We aim at studying the effect of nano-chrysin on breast cancer cell line. METHODS: The effect of chrysin loaded PCL-PEG-PCL was studied on T47D breast cancer cell line...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27770720/inhibitory-effects-of-flavonoids-extracted-from-nepalese-propolis-on-the-lps-signaling-pathway
#7
Megumi Funakoshi-Tago, Kentaro Ohsawa, Toshiyuki Ishikawa, Fumika Nakamura, Fumihito Ueda, Yuji Narukawa, Fumiyuki Kiuchi, Hiroomi Tamura, Kenji Tago, Tadashi Kasahara
Flavonoids, particularly those derived from plants, harbor biological effects such as anti-inflammation and the inhibition of cancer progression. In the present study, we investigated the effects of 10 kinds of flavonoids isolated from Nepalese propolis on the LPS signaling pathway in order to clarify their anti-inflammatory activities. Five types of flavonoids: isoliquiritigenin, chrysin, 3',4'-dihydroxy-4-methoxydalbergione, 4-methoxydalbergion, and cearoin, markedly inhibited inflammatory responses including LPS-induced NO production by suppressing the expression of iNOS mRNA and LPS-induced mRNA expression of TNFα and CCL2...
November 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27761206/effects-of-chrysin-plga-peg-nanoparticles-on-proliferation-and-gene-expression-of-mirnas-in-gastric-cancer-cell-line
#8
Farideh Mohammadian, Alireza Abhari, Hassan Dariushnejad, Alireza Nikanfar, Younes Pilehvar-Soltanahmadi, Nosratollah Zarghami
BACKGROUND: Recently, Chrysin, as a flavone, has revealed cancer chemo-preventive activity. The present experiment utilized the PLGA-PEG-chrysin complex, and free chrysin, to evaluation of the expression of miR-22, miR-34a and miR-126 in human gastric cell line. OBJECTIVES: The purpose of this study was to examine whether nano encapsulating chrysin improves the anti-cancer effect of free chrysin on AGS human gastric cell line. METHODS: Properties of the chrysin encapsulated in PLGA-PEG nanoparticles were investigated by SEM, H NMR, and FTIR...
August 2016: Iranian Journal of Cancer Prevention
https://www.readbyqxmd.com/read/27761071/inhibitory-and-cytotoxic-activities-of-chrysin-on-human-breast-adenocarcinoma-cells-by-induction-of-apoptosis
#9
Saeed Samarghandian, Mohsen Azimi-Nezhad, Abasalt Borji, Malihe Hasanzadeh, Farahzad Jabbari, Tahereh Farkhondeh, Mohammad Samini
OBJECTIVES: Chrysin, an active natural bioflavonoid found in honey and many plant extracts, was first known for its antioxidant and anti-inflammatory effects. The fact that antioxidants have several inhibitory effects against different diseases, such as cancer, led to search for food rich in antioxidants. In this study, we investigated the antiproliferative and apoptotic effects of chrysin on the cultured human breast cancer cells (MCF-7). MATERIALS AND METHODS: Cells were cultured in Roswell Park Memorial Institute medium and treated with different chrysin concentrations for three consecutive days...
July 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27684298/upregulation-of-mir-9-and-let-7a-by-nanoencapsulated-chrysin-in-gastric-cancer-cells
#10
Farideh Mohammadian, Younes Pilehvar-Soltanahmadi, Faraz Zarghami, Abolfazl Akbarzadeh, Nosratollah Zarghami
Chrysin, as a flavone, has showed cancer chemopreventive activity. The present study utilized the PLGA-PEG-chrysin to evaluate the expression of miR-9 and Let-7a in human gastric cells. The structure of nanoparticles and encapsulated chrysin was evaluated using (1)H NMR, FT-IR, and SEM. MTT assay was used for the evaluation of cytotoxicity effect of nanoencapsulated chrysin. Expression levels of miR-9 and Let7-a were studied by real-time PCR. The results demonstrated that chrysin-PLGA-PEG nanoparticles are more effective than pure chrysin in upregulation of miR-9 and Let-7a due to enhanced uptake by cells...
August 10, 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/27470961/-effects-of-chrysin-on-sphere-formation-and-ck2%C3%AE-expression-of-ovarian-cancer-stem-like-cells-derived-from-skov3-cell-line
#11
H Z Li, Y H Chen, Y L Fang, L Y Zhong, Q Q Yuan, X Y Xu, J G Cao
OBJECTIVE: To investigate whether inhibitory effect of chrysin on sphere formation of ovarian cancer stem-like cells(spheroids derived from human ovarian cancer SKOV3 cell line ) is involved in the down-regulating of the protein expression of casein kinase CK2α. METHODS: SKOV3-derived ovarian cancer stem-like cells obtained by suspension culture in stem cell-condition medium using ultra-low adhesion plate were treated with various concentrations (5.0, 10.0 and 20...
July 5, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27470413/directional-modification-of-chrysin-for-exerting-apoptosis-and-enhancing-significantly-anti-cancer-effects-of-10-hydroxy-camptothecin
#12
Qin Tang, Fangling Ji, Jianli Guo, Jingyun Wang, Yachen Li, Yongming Bao
Chrysin, one of natural flavonoid compounds, has recently been found to possess anti-inflammatory, antiallergic and anticancer properties. To increase its anticancer effects, 5 chrysin derivates were synthesized on the base of DNA intercalator structure. The inhibiting effects of chrysin and its derivatives on cancer cells Hela, BGC823, MCF-7, HepG2, and normal cells HEK-293, were evaluated by MTT assays. 5-(2'-amino) phenyl-7-cyclohexanemethylchrysin (Ch-1), a unique chrysin derivate, killed all the cancer cells but kept above 60% survival rate in normal cells HEK-293 at 62...
August 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27461522/synergistic-inhibition-of-characteristics-of-liver-cancer-stem-like-cells-with-a-combination-of-sorafenib-and-8-bromo-7-methoxychrysin-in-smmc-7721-cell-line
#13
Hui Zou, Xiaozheng Cao, Qiao Xiao, Xifeng Sheng, Kaiqun Ren, Meifang Quan, Zhengwei Song, Duo Li, Yu Zheng, Wenbin Zeng, Jianguo Cao, Yaojin Peng
Sorafenib, a multi-kinase inhibitor, has shown its promising antitumor effect in a series of clinical trials, and has been approved as the current standard treatment for advanced hepatocellular carcinoma (HCC). 8-Bromo‑7-methoxychrysin (BrMC) is a novel chrysin synthetic analogue that has been reported to inhibit the growth of various tumor cells and possess properties for targeting liver cancer stem cells (LCSCs) . The present study investigated the synergistic targeting effects on the properties of liver cancer stem-like cells (LCSLCs) by a combination of sorafenib and BrMC in SMMC-7721 cell line...
September 2016: Oncology Reports
https://www.readbyqxmd.com/read/27403965/inhibition-of-precancerous-lesions-development-in-kidneys-by-chrysin-via-regulating-hyperproliferation-inflammation-and-apoptosis-at-pre-clinical-stage
#14
Summya Rashid, Sana Nafees, Abul Vafa, Shekh Muhammad Afzal, Nemat Ali, Muneeb U Rehman, Syed Kazim Hasan, Aisha Siddiqi, Preeti Barnwal, Ferial Majed, Sarwat Sultana
Chrysin (CH) is natural, biologically active compound, belongs to flavoniod family and possesses diverse pharmacological activities as anti-inflammatory, anti-oxidant and anti-cancer. It is found in many plants, honey and propolis. In the present study, we investigated the chemopreventive efficacy of CH against N-nitrosodiethylamine (DEN) initiated and Fe-NTA induced precancerous lesions and its role in regulating oxidative injury, hyperproliferation, tumor incidences, histopathological alterations, inflammation, and apoptosis in the kidneys of Wistar rats...
September 15, 2016: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27347080/chrysin-induces-cell-apoptosis-via-activation-of-the-p53-bcl-2-caspase-9-pathway-in-hepatocellular-carcinoma-cells
#15
Qingyu Zhang, Sheng Ma, Bin Liu, Jie Liu, Runzhi Zhu, Mingyi Li
Chrysin is a major active ingredient of flavonoids, known to exhibit protective effects against various types of cancer. However, the anticancer role of chrysin against hepatocellular carcinoma (HCC) and the underlying molecular mechanisms remain unclear. In order to evaluate the effects of chrysin on cell viability and apoptosis in human HCC, HepG2 and QGY7701 cells were used in the present study. Cell viability was monitored using an MTT assay. In addition, an Annexin V-fluorescein isothiocyanate/propidium iodide kit was used for the labeling of the apoptotic cells, which were then measured using flow cytometry...
July 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27329777/dichloromethane-extracts-of-propolis-protect-cell-from-oxygen-glucose-deprivation-induced-oxidative-stress-via-reducing-apoptosis
#16
Li-Ping Sun, Xiang Xu, Hau-Hsuan Hwang, Xin Wang, Kang-Yi Su, Yi-Lin S Chen
BACKGROUND: Bee propolis, a mixture of the secretion from bee tongue gland and wax gland, was collected from the tree bud and barked by bees. The components were rich in terpenes, phenolics, and flavonoids, and had anti-cancer, anti-bacterial, anti-inflammatory, hepatoprotective, and neuroprotection abilities. However, the potential anti-oxidative stress of propolis was not well documented. This study aimed to study the protective effect of propolis on high-incident nonfatal diseases, such as stroke and cerebral infarction caused by ischemia...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27210480/phenolic-compounds-from-glycyrrhiza-pallidiflora-maxim-and-their-cytotoxic-activity
#17
Elvira E Shults, Makhmut M Shakirov, Mikhail A Pokrovsky, Tatijana N Petrova, Andrey G Pokrovsky, Petr G Gorovoy
Twenty-one phenolic compounds (1-21) including dihydrocinnamic acid, isoflavonoids, flavonoids, coumestans, pterocarpans, chalcones, isoflavan and isoflaven, were isolated from the roots of Glycyrrhiza pallidiflora Maxim. Phloretinic acid (1), chrysin (6), 9-methoxycoumestan (8), isoglycyrol (9), 6″-O-acetylanonin (19) and 6″-O-acetylwistin (21) were isolated from G. pallidiflora for the first time. Isoflavonoid acetylglycosides 19, 21 might be artefacts that could be produced during the EtOAc fractionation process of whole extract...
February 2017: Natural Product Research
https://www.readbyqxmd.com/read/27151585/chrysin-increases-the-therapeutic-efficacy-of-docetaxel-and-mitigates-docetaxel-induced-edema
#18
Hyun-Kyung Lim, Kyoung Mee Kim, Seong-Yun Jeong, Eun Kyung Choi, Joohee Jung
Docetaxel (DTX) is an effective commercial anticancer agent for chemotherapy in non-small cell lung cancer (NSCLC), breast cancer, gastric cancer, and prostate cancer, but its adverse effects including edema, neurotoxicity, and hair loss limit its application. To improve the chemotherapeutic efficacy of DTX and reduce adverse effects, combination therapy is one of the alternative methods. So chrysin, which has various biological activities including anticancer effects, was considered. In vitro, the combination of chrysin and DTX was investigated in A549 cells...
May 5, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27137679/chrysin-abundant-in-morinda-citrifolia-fruit-water-etoac-extracts-combined-with-apigenin-synergistically-induced-apoptosis-and-inhibited-migration-in-human-breast-and-liver-cancer-cells
#19
Cheng Huang, Yu-Xuan Wei, Ma-Ching Shen, Yu-Hsuan Tu, Chia-Chi Wang, Hsiu-Chen Huang
The composition of Morinda citrifolia (M. citrifolia) was determined using high-performance liquid chromatography (HPLC), and the anticancer effects of M. citrifolia extract evaluated in HepG2, Huh7, and MDA-MB-231 cancer cells. M. citrifolia fruit extracts were obtained by using five different organic solvents, including hexane (Hex), methanol (MeOH), ethyl acetate (EtOAc), chloroform (CHCl3), and ethanol (EtOH). The water-EtOAc extracts from M. citrifolia fruits was found to have the highest anticancer activity...
June 1, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27116119/5-hydroxy-7-methoxyflavone-triggers-mitochondrial-associated-cell-death-via-reactive-oxygen-species-signaling-in-human-colon-carcinoma-cells
#20
Monika Bhardwaj, Na-Hyung Kim, Souren Paul, Rekha Jakhar, Jaehong Han, Sun Chul Kang
Plant-derived compounds are an important source of clinically useful anti-cancer agents. Chrysin, a biologically active flavone found in many plants, has limited usage for cancer chemotherapeutics due to its poor oral bioavailability. 5-Hydroxy-7-methoxyflavone (HMF), an active natural chrysin derivative found in various plant sources, is known to modulate several biological activities. However, the mechanism underlying HMF-induced apoptotic cell death in human colorectal carcinoma cells in vitro is still unknown...
2016: PloS One
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