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V I Sapegin, I D Sapegin, F N Il'chenko
The effect of mydocalm (tolperison, 5 mg/kg single dose) on the dynamics of intra-abdominal hypertension (IAH), blood circulation regulation, and oxygen balance in the tissues of intestinal wall were studied in acute experiments on rabbits. Using a special stand of original design, the initial IAH level was modeled at 200 mm H2O with the subsequent stopping of further receipt of liquid during 3 hours in an elastic container in the abdominal cavity. During 3-h observation without drug administration, no changes in IAH due to the tone of muscles of the frontal abdominal wall takes place, but there is progressive deceleration of local blood flow (-35...
2014: Eksperimental'naia i Klinicheskaia Farmakologiia
V V Kovalchuk
An effect of mydocalm on muscle tone and functional rehabilitation in 1700 stroke patients (mean age 63,4 years) has been studied. Patients have been divided into two standardized groups: the basic group (850 persons who received mydocalm) and control one (850 persons who didn't receive mydocalm). The muscle tone was followed up using the Ashworth Scale, pain syndrome was assessed with the Huskisson visual analog scale and a multidimensional verbal-color pain test. The functional rehabilitation was evaluated using Barthel, Lindmark, Scandinavian and Merton & Sutton scales...
2013: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Frank Sporkert, Christophe Brunel, Marc P Augsburger, Patrice Mangin
Tolperisone (Mydocalm) is a centrally acting muscle relaxant with few sedative side effects that is used for the treatment of chronic pain conditions. We describe three cases of suicidal tolperisone poisoning in three healthy young subjects in the years 2006, 2008 and 2009. In all cases, macroscopic and microscopic autopsy findings did not reveal the cause of death. Systematic toxicological analysis (STA) including immunological tests, screening for volatile substances and blood, urine and gastric content screening by GC-MS and HPLC-DAD demonstrated the presence of tolperisone in all cases...
February 10, 2012: Forensic Science International
V A Shirokov, O P Iun, E V Bakhtereva
No abstract text is available yet for this article.
2009: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
P Miskolczi, L Vereczkey, R Frenkl
A new capillary GLC method for the determination of tolperisone in human plasma was developed. Pharmacokinetic and comparative bioavailability studies were carried out after i.v. administration and after oral administration of two different preparations of tolperisone. After i.v. administration of the drug the elimination half-life was found to be 1.55 +/- 0.7 h (mean +/- S.D.), the apparent volume of distribution to be 5.1 +/- 1.0 l/kg (mean +/- S.D.) and total body clearance to be 140.8 +/- 33.8 l/h (mean +/- S...
1987: Journal of Pharmaceutical and Biomedical Analysis
A D Solov'eva, E S Akarachkova, S A Gordeev
Mydocalm was used for the treatment of 31 patients, mean age 45 +/- 4 years, with chronic headache of tension in a dosage of 150 mg 3 times per day during 4 weeks. Twenty-six patients have completed the therapy course. Before- and after treatment, neurological status, dynamics of psychoautonomic disorders, an extent of anxiety and depression, quality of sleep, quality of life, pain syndrome measured by a number of tests, were assessed, along with electromyography and examination of nociceptive reflex. Subjective evaluation of the drug efficacy was taken into account as well...
2005: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Artur Kwaśniewski, Beata Korbuszewska-Gontarz, Sylwia Mika
The case of anaphylactic shock due to Mydocalm administration is presented. 49-year-old woman suffered from spinal osteoarthritis and she was treated with NSAIDs and Mydocalm for many years. 6 weeks before admission to hospital the first anaphylactic shock was developed with loss of consciousness after oral administration of Mydocalm. Then she was admitted to the hospital in order to diagnose and verify the suspicion whether Mydocalm caused this reaction. Percutaneous test with Mydocalm was performed and it caused anaphylactic shock...
2003: Pneumonologia i Alergologia Polska
No abstract text is available yet for this article.
December 1964: Annales Médico-psychologiques
No abstract text is available yet for this article.
May 2, 1964: Wiener Medizinische Wochenschrift
No abstract text is available yet for this article.
1961: Therapia Hungarica: Hungarian Medical Journal
No abstract text is available yet for this article.
1961: Therapia Hungarica: Hungarian Medical Journal
No abstract text is available yet for this article.
1962: Therapia Hungarica: Hungarian Medical Journal
No abstract text is available yet for this article.
1961: Therapia Hungarica: Hungarian Medical Journal
Camillo Ribi, Christophe Vermeulen, Conrad Hauser
Four patients with anaphylaxis attributed to the intake of the centrally acting muscle relaxant tolperisone hydrochloride (Mydocalm) were observed at the Emergency Department of the Geneva University Hospital between November 2001 and March 2003. All patients were middle-aged women who took tolperisone for chronic muscular pain. All reactions occurred within an hour after oral intake of this drug frequently prescribed in Switzerland. The severity of anaphylaxis ranged from urticarial reactions to shock with arterial hypotension...
June 28, 2003: Swiss Medical Weekly
G F Kolotilin, S G Abramenko, A P Iakovlev
No abstract text is available yet for this article.
1999: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
G A Ovanesian, G P Martirosian
No abstract text is available yet for this article.
1999: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
V Solozhenkin
No abstract text is available yet for this article.
1999: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
J Dulin, L Kovács, S Ramm, F Horvath, L Ebeling, R Kohnen
Sedative effects of single and repeated doses of 50 mg and 150 mg tolperisone hydrochloride (Mydocalm), a centrally active muscle-relaxing agent, were evaluated in a placebo-controlled double-blind clinical trial. A total of 72 healthy young adults balanced by sex were randomized to receive 50 mg or 150 mg tolperisone hydrochloride or placebo t.i.d. for a period of 8 days. Control examinations were performed in the mornings of days 1 and 8 before intake of the morning dose and at 1.5, 4 and 6 hours postdose...
July 1998: Pharmacopsychiatry
A Melka, R Tekle-Haimanot, F Lambien
The efficacy and safety of oral Tolperisone HCL was evaluated in double blind, placebo-controlled, randomized trial in 72 patients with neurolathyrism in stages I, II, and III of the disease at Kolla Duba Health Centre of Dembia District of North Gondar between January and April 1995. Taken orally daily for 12 weeks, tolperisone HCL (Mydocalm) in a dose of 150 milligrams (mgs) twice daily significantly improved subjective complaints such as muscle cramps, heaviness of the legs, startle attacks, flexor spasms and repeated falls...
April 1997: Ethiopian Medical Journal
I M Alibekov
Mydocalm and nootropil combination was used for treatment of antibiotic neurosensory hypoacusia (24 patients) and non-antibiotic hypoacusis (11 patients). 100 mg of mydocalm was diluted in 10.0 ml of 0.9% sodium chloride and injected intravenously. 20% solution of nootropil (5.0 ml) was injected intramuscularly. The 14-day course produced subjective response. Noise in the ears and heavy head feeling disappeared. As shown by measurements of auditory thresholds, improvement of hearing was only subjective. The responses were similar in both groups of patients...
1997: Vestnik Otorinolaringologii
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