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valvular heart

Kelly Kohorst, Mias Pretorius
Mitral regurgitation is the most common valvular disease and significant (moderate/severe) mitral regurgitation is found in 2.3% of the population older than 65 years. New transcatheter minimally invasive technologies are being developed to address mitral valve disease in patients deemed too high a risk for conventional open-heart surgery. There are several features of the mitral valve (saddle-shaped noncalcified annulus with irregular leaflet geometry) that make a transcatheter approach to repair or replacing the valve more challenging compared with the aortic valve...
June 1, 2018: Seminars in Cardiothoracic and Vascular Anesthesia
Athina Chasapi, Adam Hobbs, Theodore Velissaris, Benoy N Shah
A 77 year old male underwent elective bioprosthetic aortic valve replacement (23mm Carpentier-Edwards Perimount MagnaEase) for severe aortic stenosis. His pre-discharge transthoracic echocardiogram (TTE) was normal. He presented 9 days after surgery with dyspnoea and fever. He was in sinus rhythm. Blood cultures were taken and he was commenced on empirical antibiotics for possible infective endocarditis (subsequently all negative). Repeat TTE showed a well-seated prosthesis without regurgitation but elevated gradients (peak / mean gradients 49 / 22 mmHg respectively)...
June 12, 2018: Echo Research and Practice
L V Prokopova, M Y Sitnikova
BACKGROUND: A method for predicting one-year survival of patients with heart failure and reduced ejection fraction (HFrEF) is required to choose a management tactics and determine indications for high-tech care at the outpatient stage. AIM: To develop a method for proper prediction of survival of patients with HFrEF in outpatient clinics. MATERIALS AND METHODS: This was a prospective study of 212 patients with functional class II-IV CHF of non-valvular origin and LV EF (Simpson) ≤35 % aged 18-70, including 176 (83 %) men and 36 (17 %) women who had given an informed consent to participate in the study...
2018: Kardiologiia
Yuki Nakamura, Bijoy Thattaliyath, Marco Ricci
A combination of hypoplasia of the left side of the heart, a hypoplastic aortic arch, a large patent ductus arteriosus, and valvular pulmonary stenosis is very rare. The severity of the valvular pulmonary stenosis in this setting is difficult to judge preoperatively. Here, we describe a newborn with borderline hypoplasia of the left side of the heart, a hypoplastic aortic arch, a large patent ductus arteriosus, and valvular pulmonary stenosis, who underwent the Norwood procedure successfully. The purpose of this report is to share the perioperative course of the patient and our decision-making process that was not straightforward...
June 8, 2018: Annals of Thoracic Surgery
Arnold C T Ng, Victoria Delgado, Jeroen J Bax
PURPOSE OF REVIEW: Left ventricular (LV) global longitudinal strain (GLS) is widely recognized as a more sensitive measure of LV systolic function compared with LV ejection fraction (LVEF). In addition, the measurement of LVGLS is more reproducible than two-dimensional LVEF. Current guidelines for diagnosis and treatment of valvular heart disease include LVEF as one of the parameters to take into consideration in the clinical decision-making. However, a large body of evidence is showing that LVGLS may be a better prognosticator than LVEF in various valvular heart diseases...
June 9, 2018: Current Opinion in Cardiology
Mehmet Akif Topcuoglu, Liping Liu, Dong-Eog Kim, M Edip Gurol
Cardiac embolism continues to be a leading etiology of ischemic strokes worldwide. Although pathologies that result in cardioembolism have not changed over the past decade, there have been significant advances in the treatment and stroke prevention methods for these conditions. Atrial fibrillation remains the prototypical cause of cardioembolic strokes. The availability of new long-term monitoring devices for atrial fibrillation detection such as insertable cardiac monitors has allowed accurate detection of this leading cause of cardioembolism...
May 2018: Journal of Stroke
S Harikrishnan, G Sanjay, M Ashishkumar, Jaideep Menon, Gopalan Nair Rajesh, Raman Krishna Kumar, A George Koshy, Thankachan V Attacheril, Raju George, Eapen Punnoose, S M Ashraf, S R Arun, Mohammed Cholakkal, Panniyammakal Jeemon
BACKGROUND: Epidemiological data on pulmonary hypertension (PH) are scarce from developing countries including India. METHODS: We established a multi-center registry of PH, the PRO-KERALA registry, in Kerala, India. Fifty hospitals enrolled consecutive adult (>18 years) patients for one year. Echocardiographic criteria (right ventricular systolic pressure - RVSP > 50 mmHg) or invasively obtained mean pulmonary artery pressure > 25 mmHg was the criteria for entry...
August 15, 2018: International Journal of Cardiology
Sudha Ramesh, Shreyas Kudachi, Sandip Basu
We herein report the clinical course and gratifying responses obtained in functioning metastatic neuroendocrine tumor (NET) with carcinoid heart disease (CaHD; uncontrolled by long acting octreotide) treated with 177 Lu-DOTATATE, that enabled taking the patient for corrective valvular surgery, in addition to its positive impact on the health related quality of life, symptomatic improvement (from baseline NYHA grade III to NYHA grade I after 6 cycles), disease stabilization and substantial reduction of 5-hydroxy indole acetic acid (5-HIAA) in the patient...
June 8, 2018: Journal of Nuclear Medicine Technology
Giovanni Luca Botto, Carlo Piemontese, Giovanni Russo
Atrial fibrillation (AF) is a relevant cardiovascular condition that is more prevalent in the elderly patients aged over 65 years. AF, with abnormal rate and rhythm can cause symptoms directly or indirectly by exacerbating other frequently coexisting cardiac conditions such as valvular heart disease, hypertension, ischemic cardiomyopathy, dilated cardiomyopathy, and hypertrophic cardiomyopathy. Evidence suggests that aging-related cardiovascular changes predispose to the elderly to AF. Current therapeutic options such as antiarrhythmic drugs have not been extensively evaluated in the elderly population...
June 7, 2018: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
Nagesh Chopra, Matthew S Tong, Steven J Yakubov
No abstract text is available yet for this article.
February 2018: HeartRhythm Case Reports
Kiran Musunuru, Farah Sheikh, Rajat M Gupta, Steven R Houser, Kevin O Maher, David J Milan, Andre Terzic, Joseph C Wu
Induced pluripotent stem cells (iPSCs) offer an unprece-dented opportunity to study human physiology and disease at the cellular level. They also have the potential to be leveraged in the practice of precision medicine, for example, personalized drug testing. This statement comprehensively describes the provenance of iPSC lines, their use for cardiovascular disease modeling, their use for precision medicine, and strategies through which to promote their wider use for biomedical applications. Human iPSCs exhibit properties that render them uniquely qualified as model systems for studying human diseases: they are of human origin, which means they carry human genomes; they are pluripotent, which means that in principle, they can be differentiated into any of the human body's somatic cell types; and they are stem cells, which means they can be expanded from a single cell into millions or even billions of cell progeny...
January 2018: Circulation. Genomic and precision medicine
Saro H Armenian, Gregory T Armstrong, Gregory Aune, Eric J Chow, Matthew J Ehrhardt, Bonnie Ky, Javid Moslehi, Daniel A Mulrooney, Paul C Nathan, Thomas D Ryan, Helena J van der Pal, Elvira C van Dalen, Leontien C M Kremer
Cardiovascular disease (CVD), which includes cardiomyopathy/heart failure, coronary artery disease, stroke, pericardial disease, arrhythmias, and valvular and vascular dysfunction, is a major concern for long-term survivors of childhood cancer. There is clear evidence of increased risk of CVD largely attributable to treatment exposures at a young age, most notably anthracycline chemotherapy and chest-directed radiation therapy, and compounded by traditional cardiovascular risk factors accrued during decades after treatment exposure...
June 6, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Young Hoon Yoon, Sung Ha Kim, Yong Min Kim, Ki-Sang Rha
Sinonasal organized hematoma, which has locally aggressive characteristics, is a non-neoplastic disease. We report a rare case of sphenoid sinus organized hematoma causing acute visual loss. A 35-year-old male presented with progressive headaches, retro-orbital pain, and frequent epistaxis. He had a medical history of aplastic anemia and of taking warfarin for a valvular heart disease. On image studies, an expansive soft tissue density lesion with bony destruction was found in his left sphenoid sinus. While waiting for elective surgery, acute visual loss occurred...
June 1, 2018: European Journal of Ophthalmology
M Langouo, I Chouchane, J Lalmand, M Joris, P Dubois
The false aneurysm of the left ventricle is a rare complication after a mitral valvular surgery. It results from the rupture of the ventricular wall inside an adhering pericardium, thus constituting a cavity whose wall is devoid of myocardial elements and communicates with the ventricle by a large collar. Its clinical presentation remains not very specific with an insidious spontaneous evolution which is generally done towards rupture with sudden death by tamponade. Various sophisticated modern diagnostic techniques allows a precise diagnosis...
May 31, 2018: Revue Médicale de Bruxelles
Lucia Musumeci, Nicolas Jacques, Alexandre Hego, Alain Nchimi, Patrizio Lancellotti, Cécile Oury
Aortic Valve Disease (AVD) is the most common Valvular Heart Disease (VHD), affecting millions of people worldwide. Severe AVD is treated in most cases with prosthetic aortic valve replacement, which involves the substitution of the native aortic valve with a prosthetic one. In this review we will discuss the different types of prosthetic aortic valves available for implantation and the challenges faced by patients, medical doctors, researchers and manufacturers, as well as the approaches that are taken to overcome them...
2018: Frontiers in Cardiovascular Medicine
Daniel Lyon Fink, Yoram Chaiter, Samuel Menahem, Rivka Farkash, Yossy Machluf
Background: Rheumatic heart disease (RHD) among Ethiopian school children was recently found to be 1.4%. Immigration of the Jewish population from the Gondar region to Israel created an opportunity for further enquiry. Methods: A cross-sectional study of the cardiac status of 113,671 adolescent recruits aged 16-19 years from the northern district of Israel who completed the medical profiling process over a 22-year period. Results: 140 recruits had a history of rheumatic fever (0...
2018: Frontiers in Public Health
Chandana Shekar, Matthew Budoff
Coronary artery calcification(CAC) is reflective of atherosclerotic disease and incrementally predictive of future cardiovascular events, independent of traditional risk factors. Extra coronary calcium such as aortic valve calcification, which can be identified and quantified by Computed Tomography(CT) imaging, has shown to predict future cardiovascular events in both asymptomatic and symptomatic (ie - stable angina and acute coronary syndrome) settings. It has hence been a vital tool in studies involving new therapies for cardiovascular disease...
June 4, 2018: Expert Review of Cardiovascular Therapy
Clotilde Chatre, François Roubille, Hélène Vernhet, Christian Jorgensen, Yves-Marie Pers
INTRODUCTION: Chloroquine and hydroxychloroquine are widely used in the long-term treatment of connective tissue disease and usually considered safe. However, chloroquine- or hydroxychloroquine-related cardiac disorder is a rare but severe adverse event, which can lead to death. This systematic review investigates cardiac complications attributed to chloroquine and hydroxychloroquine. METHODS: PubMED, EMBASE, and Cochrane database searches were conducted using keywords derived from MeSH terms...
June 1, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
Wenrui Ma, Wei Ye, Jing Zhang, Wei Zhang, Weihua Wu, Ye Kong
We sought to investigate the impact of full annuloplasty rings versus C-shape bands on mitral annular geometry in the presence of fibroelastic deficiency (FED), as assessed by intraoperative three-dimensional transesophageal echocardiography (3DTEE). We retrospectively selected 65 patients who underwent mitral valve repair for severe mitral regurgitation caused by FED using full rings (the Ring group, n = 30) and C-shape bands (the Band group, n = 35). 71 controls without valvular heart disease were also included...
May 29, 2018: International Journal of Cardiovascular Imaging
Rama Chaudhry, Prathyusha Kokkayil, Arnab Ghosh, Tej Bahadur, Kamala Kant, Tanu Sagar, Sunil Kumar Kabra, Rakesh Lodha, Aparajit Ballav Dey, Vimala Menon
Background & objectives: : Bartonella henselae causes infections which closely resemble febrile illness and chronic diseases such as tuberculosis and haematological malignancies. There are not many studies on Bartonella infections from India. The present study was undertaken to diagnose B. henselae infection in diverse clinical conditions in a tertiary care hospital in north India. Methods: A total of 145 patients including those with fever and lymphadenopathy, infective endocarditis and neuroretinitis were enrolled in the study...
February 2018: Indian Journal of Medical Research
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