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https://www.readbyqxmd.com/read/29168683/why-aren-t-our-digital-solutions-working-for-everyone
#1
Brian Van Winkle, Neil Carpenter, Mauro Moscucci
The article explores a digital injustice that is occurring across the country: that digital solutions intended to increase health care access and quality often neglect those that need them most. It further shows that when it comes to digital innovation, health care professionals and technology companies rarely have any incentives to focus on underserved populations. Nevertheless, we argue that the technologies that are leaving these communities behind are the same ones that can best support them. The key is in leveraging these technologies with: (a) design features that accommodate various levels of technological proficiency (e-literacy), (b) tech-enabled community health workers and navigators who can function as liaisons between patients and clinicians, and (c) analytics and customer relationship management tools that enable health care professionals and support networks to provide the right interventions to the right patients...
November 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/29168682/how-should-organizations-promote-equitable-distribution-of-benefits-from-technological-innovation-in-health-care
#2
Satish Nambisan, Priya Nambisan
Technological innovations typically benefit those who have good access to and an understanding of the underlying technologies. As such, technology-centered health care innovations are likely to preferentially benefit users of privileged socioeconomic backgrounds. Which policies and strategies should health care organizations adopt to promote equitable distribution of the benefits from technological innovations? In this essay, we draw on two important concepts-co-creation (the joint creation of value by multiple parties such as a company and its customers) and digitalization (the application of new digital technologies and the ensuing changes in sociotechnical structures and relationships)-and propose a set of policies and strategies that health care organizations could adopt to ensure that benefits from technological innovations are more equitably distributed among all target populations, including resource-poor communities and individuals...
November 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/29168564/grade-related-differences-in-strategy-use-in-multidigit-division-in-two-instructional-settings
#3
Marian Hickendorff, Joke Torbeyns, Lieven Verschaffel
We aimed to investigate upper elementary children's strategy use in the domain of multidigit division in two instructional settings: the Netherlands and Flanders (Belgium). A cross-sectional sample of 119 Dutch and 122 Flemish fourth to sixth graders solved a varied set of multidigit division problems. With latent class analysis, three distinct strategy profiles were identified: children consistently using number-based strategies, children combining the use of column-based and number-based strategies, and children combining the use of digit-based and number-based strategies...
November 23, 2017: British Journal of Developmental Psychology
https://www.readbyqxmd.com/read/29168381/cellular-biosensors-with-engineered-genetic-circuits
#4
Behide Saltepe, Ebru Sahin Kehribar, Side Selin Su Yirmibesoglu, Urartu Ozgur Safak Seker
: An increasing interest in building novel biological devices with designed cellular functionalities has triggered the search of innovative tools for biocomputation. Utilizing the tools of synthetic biology, numerous genetic circuits have been imple-mented such as engineered logic operation in analog and digital circuits. Whole cell biosensors are widely used biological devices that employ several biocomputation tools to program cells for desired functions. Up to date, a wide range of whole-cell biosensors have been designed and implemented for disease theranostics, biomedical applications and environmental monitoring...
November 23, 2017: ACS Sensors
https://www.readbyqxmd.com/read/29168302/analysing-and-navigating-natural-products-space-for-generating-small-diverse-but-representative-chemical-libraries
#5
REVIEW
Steve O'Hagan, Douglas B Kell
BACKGROUND: Armed with the digital availability of two natural products libraries, amounting to some 195,885 molecular entities, we ask the question of how we can best sample from them to maximise their 'representativeness' in smaller and more usable libraries of 96, 384, 1152 and 1920 molecules. Purpose and scope. The term 'representativeness' is intended to include diversity, but for numerical reasons (and the likelihood of being able to perform a QSAR) it is necessary to focus on areas of chemical space that are more highly populated...
November 23, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29168185/yy1-suppresses-proliferation-and-migration-of-pancreatic-ductal-adenocarcinoma-by-regulating-the-cdkn3-mdm2-p53-p21-signaling-pathway
#6
Dongfang Liu, Jingjing Zhang, Yang Wu, Guodong Shi, Hao Yuan, Zipeng Lu, Qicong Zhu, Pengfei Wu, Cheng Lu, Feng Guo, Jianmin Chen, Kuirong Jiang, Yi Miao
Pancreatic ductal adenocarcinoma (PDAC) is one of the malignant lethal tumors. It has been reported that the transcriptional regulator Yin Yang-1 (YY1) suppressed the invasion and metastasis of PDAC. However, the function of YY1 on proliferation and migration of pancreatic cancer remains to be clarified. In this study, we found that YY1 overexpression or knockdown can inhibit or promote the proliferation and migration of pancreatic cancer cells. Digital gene expression (DGE) sequencing indicates that cyclin-dependent kinase inhibitor 3 (CDKN3) may be the candidate target gene of YY1...
November 23, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29168116/reference-to-self-and-other-in-the-digital-public-sphere-the-case-of-political-blogs
#7
Barbara De Cock, Cristian González Arias
In this paper, we analyze how a political blog author (Spanish Alejo Vidal-Quadras) establishes the reference to self and other in his blog entries. We furthermore look into how the commentators to this blog react and establish reference to self and other in the digital public sphere. More concretely, we show that they not only take up the references established by the main blog author but also create new references. These allow, on the one hand, for profiling themselves as part of a group and, on the other hand, identifying their interlocutor among the variety of possible interlocutors in the digital public sphere...
November 22, 2017: Journal of Psycholinguistic Research
https://www.readbyqxmd.com/read/29168082/a-pilot-study-of-neuropsychological-functions-apoe-and-amyloid-imaging-in-patients-with-gliomas
#8
D D Correa, M Kryza-Lacombe, X Zhou, R E Baser, B J Beattie, Z Beiene, J Humm, L M DeAngelis, I Orlow, W Weber, J Osborne
Brain tumor patients treated with radiotherapy (RT) often develop cognitive dysfunction, and recent studies suggest that the APOE ε-4 allele may influence cognitive outcome. The ε-4 allele is known to promote beta (β) amyloid deposition in the cortex, and preliminary evidence suggests that RT may be associated with this process. However, it is unknown whether β-amyloid accumulation contributes to treatment neurotoxicity. In this pilot study, we assessed neuropsychological functions and β-amyloid retention using (18)F-florbetaben (FBB) PET in a subset of brain tumor patients who participated in our study of APOE polymorphisms and cognitive functions...
November 22, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29167984/x-ray-micro-computed-tomography-in-pediatric-surgery-a-new-tool-for-studying-embryos
#9
Susann Brosig, N Peukert, R Metzger, H Schneider, R Haak, J Gosemann, M Lacher, D Kluth
PURPOSE: The embryology of common congenital malformations is discussed controversially. Studies are hampered by a shortage of study material and techniques which require partial or complete preparation and therewith destruction of embryos. X-ray micro-computed-tomography (µCT) is a technical opportunity keeping the embryos intact. Thus, the aim of this study was to assess the applicability of µCT in embryonic research compared to the anatomical information obtained by scanning electron microscopy (SEM)...
November 22, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29167748/genetic-stability-of-rift-valley-fever-virus-mp-12-vaccine-during-serial-passages-in-culture-cells
#10
Nandadeva Lokugamage, Tetsuro Ikegami
Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa which affects both ruminants and humans. RVF causes serious damage to the livestock industry and is also a threat to public health. The Rift Valley fever virus has a segmented negative-stranded RNA genome consisting of Large (L)-, Medium (M)-, and Small (S)-segments. The live-attenuated MP-12 vaccine is immunogenic in livestock and humans, and is conditionally licensed for veterinary use in the U.S. The MP-12 strain encodes 23 mutations (nine amino acid substitutions) and is attenuated through a combination of mutations in the L-, M-, and S-segments...
2017: NPJ Vaccines
https://www.readbyqxmd.com/read/29167720/peek-polymer-in-orthodontics-a-pilot-study-on-children
#11
Gaetano Ierardo, Valeria Luzzi, Michela Lesti, Iole Vozza, Orlando Brugnoletti, Antonella Polimeni, Maurizio Bossù
The purpose of the study has been making the orthodontic space maintainers in PEEK polymer (Polyetheretherketone) through a digital workflow. New digital technologies are taking hold in diagnosis, therapy and in dental laboratories. The digital world can help dentist in diagnosis and therapy: -diagnosis through the acquisition of radiographic images (CBCT) or scanners which allow the creation of 3D digital models - about therapy thanks to dental CAD CAM system. It consists of design devices through an dedicated software CAD and then realize devices through CAM system...
October 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29167707/solubility-and-ph-of-bioceramic-root-canal-sealers-a-comparative-study
#12
Claudio Poggio, Alberto Dagna, Matteo Ceci, Maria-Vittoria Meravini, Marco Colombo, Giampiero Pietrocola
Background: This study compared the solubility and the pH of different root canal sealers in vitro. Material and Methods: BioRoot™RCS, TotalFill BC Sealer, MTA Fillapex, SealapexTM, AH Plus, EasySeal, Pulp Canal Sealer™ and N2 were tested. Similar specimens were prepared using ring molds with an internal diameter of 20 ± 0,1 mm and a height of 1,5 ± 0,1 mm and digitally weighted to register the mass of each specimen before and after immersion in distilled water...
October 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29167499/a-novel-multiplex-hrm-assay-to-detect-clopidogrel-resistance
#13
Lichen Zhang, Xiaowei Ma, Guoling You, Xiaoqing Zhang, Qihua Fu
Clopidogrel is an antiplatelet medicine used to prevent blood clots in patients who have had a heart attack, stroke, or other symptoms. Variability in the clinical response to clopidogrel treatment has been attributed to genetic factors. In particular, five SNPs of rs4244285, rs4986893, rs12248560, rs662 and rs1045642 have been associated with resistance to clopidogrel therapy in Chinese population. This work involves the development of a multiplex high-resolution melting (HRM) assay to genotype all five of these loci in 2 tubes...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29167425/experimentally-simulating-the-dynamics-of-quantum-light-and-matter-at-deep-strong-coupling
#14
N K Langford, R Sagastizabal, M Kounalakis, C Dickel, A Bruno, F Luthi, D J Thoen, A Endo, L DiCarlo
The quantum Rabi model describing the fundamental interaction between light and matter is a cornerstone of quantum physics. It predicts exotic phenomena like quantum phase transitions and ground-state entanglement in ultrastrong and deep-strong coupling regimes, where coupling strengths are comparable to or larger than subsystem energies. Demonstrating dynamics remains an outstanding challenge, the few experiments reaching these regimes being limited to spectroscopy. Here, we employ a circuit quantum electrodynamics chip with moderate coupling between a resonator and transmon qubit to realise accurate digital quantum simulation of deep-strong coupling dynamics...
November 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/29166868/prevalence-of-esr1-e380q-mutation-in-tumor-tissue-and-plasma-from-japanese-breast-cancer-patients
#15
Takashi Takeshita, Yutaka Yamamoto, Mutsuko Yamamoto-Ibusuki, Aiko Sueta, Mai Tomiguchi, Keiichi Murakami, Yoko Omoto, Hirotaka Iwase
BACKGROUND: ESR1 mutations have attracted attention as a potentially important marker and treatment target in endocrine therapy-resistant breast cancer patients. The E380Q mutation, which is one of the ESR1 mutations, is associated with estradiol (E2) hypersensitivity, increased DNA binding to the estrogen response element, and E2-independent constitutive trans-activation activity, but its frequency in ESR1 mutations remains unknown. The present study aimed to investigate the E380Q mutation in comparison with the other representative ESR1 mutations...
November 22, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29166855/identification-of-differentially-expressed-genes-in-flower-leaf-and-bulb-scale-of-lilium-oriental-hybrid-sorbonne-and-putative-control-network-for-scent-genes
#16
Fang Du, Junmiao Fan, Ting Wang, Yun Wu, Donald Grierson, Zhongshan Gao, Yiping Xia
BACKGROUND: Lily is an economically important plant, with leaves and bulbs consisting of overlapping scales, large ornamental flowers and a very large genome. Although it is recognized that flowers and bulb scales are modified leaves, very little is known about the genetic control and biochemical differentiation underlying lily organogenesis and development. Here we examined the differentially expressed genes in flower, leaf and scale of lily, using RNA-sequencing, and identified organ-specific genes, including transcription factors, genes involved in photosynthesis in leaves, carbohydrate metabolism in bulb scales and scent and color production in flowers...
November 22, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29166818/can-digital-technology-enhance-social-connectedness-among-older-adults-a-feasibility-study
#17
Barbara Barbosa Neves, Rachel Franz, Rebecca Judges, Christian Beermann, Ron Baecker
This study examined the feasibility of a novel communication technology to enhance social connectedness among older adults in residential care. Research suggests that technology can create opportunities for social connectedness, helping alleviate social isolation and loneliness. Studies on implementation and feasibility of such technological interventions, particularly among frail and institutionalized older adults, are scant. Data were gathered in a 3-month deployment with 12 older adults, including semistructured interviews with participants and relatives/friends, psychometric scales, field observations, and usability tests...
November 1, 2017: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/29166809/the-relationship-of-obesity-to-the-timing-of-permanent-tooth-emergence-in-czech-children
#18
Romana Šindelářová, Petr Soukup, Zdeněk Broukal
BACKGROUND: The aim of this study was to investigate the influence of BMI on the timing of permanent tooth emergence in Czech children. OBJECTIVES: In this cross-sectional study, 1370 Czech children were examined. The age, gender, weight, height, all emerged permanent teeth (except third molars) of each child were all recorded. A tooth is defined as having emerged when at least any part of it has penetrated the gingiva. METHODS: A logistic regression model was used to calculate the median emergence age per tooth for both genders separately and BMI was used as a factor variable to detect statistically significant differences in the times of tooth emergence within pairs of BMI groups...
November 22, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29166665/meditation-experts-try-virtual-reality-mindfulness-a-pilot-study-evaluation-of-the-feasibility-and-acceptability-of-virtual-reality-to-facilitate-mindfulness-practice-in-people-attending-a-mindfulness-conference
#19
María V Navarro-Haro, Yolanda López-Del-Hoyo, Daniel Campos, Marsha M Linehan, Hunter G Hoffman, Azucena García-Palacios, Marta Modrego-Alarcón, Luis Borao, Javier García-Campayo
Regular mindfulness practice benefits people both mentally and physically, but many populations who could benefit do not practice mindfulness. Virtual Reality (VR) is a new technology that helps capture participants' attention and gives users the illusion of "being there" in the 3D computer generated environment, facilitating sense of presence. By limiting distractions from the real world, increasing sense of presence and giving people an interesting place to go to practice mindfulness, Virtual Reality may facilitate mindfulness practice...
2017: PloS One
https://www.readbyqxmd.com/read/29166479/-challenges-and-opportunities-in-digital-health
#20
Ana O Franco, M Gabriela M Gomes
No abstract text is available yet for this article.
November 21, 2017: Cadernos de Saúde Pública
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