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https://www.readbyqxmd.com/read/29334632/capillary-electrophoresis-mass-spectrometry-for-targeted-and-untargeted-analysis-of-the-sub-5%C3%A2-kda-urine-metabolome-of-patients-with-prostate-or-bladder-cancer-a-feasibility-study
#1
Matthew S MacLennan, Miranda G M Kok, Laiel Soliman, Alan So, Antonio Hurtado-Coll, David D Y Chen
Targeted and untargeted analyses of the sub-5 kDa urine metabolome of genitourinary cancer patients (prostate and/or bladder) were performed without chemical derivatization using capillary electrophoresis-electrospray ionization-mass spectrometry (CE-ESI-MS). For targeted analysis, endogenous levels of sarcosine and 5 other amino acid metabolites implicated in the progression of prostate cancer were quantified in four patients and in a pooled urine sample from healthy volunteers. An untargeted analysis (m/z 50 to 850) of patient urine was performed using the same CE-ESI-MS system identifying over 400 distinct molecular features per patient...
January 7, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29334548/plasma-and-intracellular-pharmacokinetics-of-tenofovir-in-patients-switched-from-tenofovir-disoproxil-fumarate-to-tenofovir-alafenamide
#2
Anthony T Podany, Sara H Bares, Joshua Havens, Ravi Dyavar Shetty, Jennifer O'neill, Sarah Lee, Courtney V Fletcher, Susan Swindells, Kimberly K Scarsi
OBJECTIVES: The aim of the study was to compare the intra-individual plasma and intracellular peripheral blood mononuclear cell (PBMC) pharmacokinetics (PK) of tenofovir (TFV) and its intracellular metabolite, tenofovir-diphosphate (TFV-DP) in patients switched from a fixed dose combination (FDC) tablet of tenofovir disoproxil fumarate (TDF)/ emtricitabine (FTC)/ elvitegravir (EVG)/ cobicistat (COBI) to a FDC containing tenofovir alafenamide (TAF)/FTC/EVG/COBI. DESIGN: A single arm, prospective, non-randomized, cross-over, PK study in patients receiving a TDF-containing regimen (TDF 300 mg/ FTC 200 mg/ EVG 150 mg/ COBI 150 mg) switched to a TAF-containing FDC regimen (TAF 10 mg/ FTC 200 mg/ EVG 150 mg/ COBI 150 mg)...
January 13, 2018: AIDS
https://www.readbyqxmd.com/read/29334390/smartphone-integrated-optoelectrowetting-sioew-for-on-chip-sample-processing-and-microscopic-detection-of-water-quality
#3
Dongyue Jiang, Seunguk Lee, Sung Woo Bae, Sung-Yong Park
With the increasing capabilities and ubiquity of smartphones and their associated digital cameras, this study presents a smartphone integrated optoelectrowetting (SiOEW) device as a simple, portable tool capable of on-chip water sample preparation and microscopic detection of the target cells in water samples, which significantly reduce the detection time and the labor cost required for water quality monitoring. A commercially available smartphone is used as a low-intensity portable light source to perform optoelectrowetting (OEW)-based microfluidic operations such as droplet transportation, merging, mixing, and immobilization on a hydrophobic detection zone...
January 15, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29334259/development-of-three-dimensional-brain-arteriovenous-malformation-model-for-patient-communication-and-young-neurosurgeon-education
#4
Mengqi Dong, Guangzhong Chen, Kun Qin, Xiaowen Ding, Dong Zhou, Chao Peng, Shaojian Zeng, Xianming Deng
PURPOSE: Rapid prototyping technology is used to fabricate three-dimensional (3D) brain arteriovenous malformation (AVM) models and facilitate presurgical patient communication and medical education for young surgeons. METHODS: Two intracranial AVM cases were selected for this study. Using 3D CT angiography or 3D rotational angiography images, the brain AVM models were reconstructed on personal computer and the rapid prototyping process was completed using a 3D printer...
January 15, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29334223/a-novel-color-modulation-analysis-strategy-through-tunable-multiband-laser-for-nanoparticle-identification-and-evaluation
#5
Xuan Cao, Gang Lei, Jingjing Feng, Qi Pan, Xiaodong Wen, Yan He
Creating color difference and improving the color resolution in digital imaging is crucial for better application of color analy-sis. Herein, a novel color modulation analysis strategy was developed by using a homemade tunable multiband laser illumi-nation device, in which the portions of R, G, and B components of the illumination light are discretionarily adjustable, and hence the sample color could be visually modulated continuously in the RGB color space. Through this strategy, the color appearance of single gold nanorods (AuNRs) under dark-field microscopy, was migrated from the spectrally insensitive red region to the spectrally sensitive green-yellow-red region...
January 15, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29334192/digitalizing-self-assembled-chiral-superstructures-for-optical-vortex-processing
#6
Peng Chen, Ling-Ling Ma, Wei Duan, Ji Chen, Shi-Jun Ge, Zhi-Han Zhu, Ming-Jie Tang, Ran Xu, Wei Gao, Tao Li, Wei Hu, Yan-Qing Lu
Cholesteric liquid crystal (CLC) chiral superstructures exhibit unique features; that is, polychromatic and spin-determined phase modulation. Here, a concept for digitalized chiral superstructures is proposed, which further enables the arbitrary manipulation of reflective geometric phase and may significantly upgrade existing optical apparatus. By encoding a specifically designed binary pattern, an innovative CLC optical vortex (OV) processor is demonstrated. Up to 25 different OVs are extracted with equal efficiency over a wavelength range of 116 nm...
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29333754/a-guide-to-analysis-and-reconstruction-of-serial-block-face-scanning-electron-microscopy-data
#7
E Cocks, M Taggart, F C Rind, K White
Serial block face scanning electron microscopy (SBF-SEM) is a relatively new technique that allows the acquisition of serially sectioned, imaged and digitally aligned ultrastructural data. There is a wealth of information that can be obtained from the resulting image stacks but this presents a new challenge for researchers - how to computationally analyse and make best use of the large datasets produced. One approach is to reconstruct structures and features of interest in 3D. However, the software programmes can appear overwhelming, time-consuming and not intuitive for those new to image analysis...
January 15, 2018: Journal of Microscopy
https://www.readbyqxmd.com/read/29333590/advantages-and-disadvantages-in-image-processing-with-free-software-in-radiology
#8
Katrin Muradas Mujika, Juan Antonio Juanes Méndez, Andrés Framiñan de Miguel
Currently, there are sophisticated applications that make it possible to visualize medical images and even to manipulate them. These software applications are of great interest, both from a teaching and a radiological perspective. In addition, some of these applications are known as Free Open Source Software because they are free and the source code is freely available, and therefore it can be easily obtained even on personal computers. Two examples of free open source software are Osirix Lite® and 3D Slicer®...
January 15, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29333463/characteristics-of-smoothing-filters-to-achieve-the-guideline-recommended-positron-emission-tomography-image-without-harmonization
#9
Yuji Tsutsui, Shinichi Awamoto, Kazuhiko Himuro, Yoshiyuki Umezu, Shingo Baba, Masayuki Sasaki
Objectives: The aim of this study is to examine the effect of different smoothing filters on the image quality and SUVmax to achieve the guideline recommended positron emission tomography (PET) image without harmonization. Methods: We used a Biograph mCT PET scanner. A National Electrical Manufacturers Association (NEMA) the International Electrotechnical Commission (IEC) body phantom was filled with 18F solution with a background activity of 2.65 kBq/mL and a sphere-to-background ratio of 4...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29333205/high-aspect-ratio-induced-spontaneous-generation-of-monodisperse-picolitre-droplets-for-digital-pcr
#10
Xiaonan Xu, Haojun Yuan, Ruyuan Song, Miao Yu, Ho Yin Chung, Youmin Hou, Yuhe Shang, Hongbo Zhou, Shuhuai Yao
Droplet microfluidics, which involves micrometer-sized emulsion droplets on a microfabricated platform, has been demonstrated as a unique system for many biological and chemical applications. Robust and scalable generation of monodisperse droplets at high throughput is of fundamental importance for droplet microfluidics. Classic designs for droplet generation employ shear fluid dynamics to induce the breakup of droplets in a two-phase flow and the droplet size is sensitive to flow rate fluctuations, often resulting in polydispersity...
January 2018: Biomicrofluidics
https://www.readbyqxmd.com/read/29333127/quality-assurance-procedures-based-on-dosimetric-gamma-analysis-as-a-fast-reliable-tool-for-commissioning-brachytherapy-treatment-planning-systems
#11
Grzegorz Zwierzchowski, Grzegorz Bieleda, Janusz Skowronek
Background: Fast and easily repeatable methods for commissioning procedures for brachytherapy (BT) treatment planning systems (TPS) are needed. Radiochromic film dosimetry with gamma analysis is widely used in external beam quality assurance (QA) procedures and planar film dosimetry is also increasingly used for verification of the dose distribution in BT applications. Using the gamma analysis method for comparing calculated and measured dose data could be used for commissioning procedures of the newly developed TG-186 and MBDCA calculation algorithms...
December 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/29333084/effects-of-%C3%AE-mangostin-on-viability-growth-and-cohesion-of-multicellular-spheroids-derived-from-human-breast-cancer-cell-lines
#12
Giuseppe Scolamiero, Claudia Pazzini, Francesca Bonafè, Carlo Guarnieri, Claudio Muscari
Background: α-Mangostin (αMG) is extracted from Garcinia mangostana Linn and exerts antiproliferative activities. Although several researches on αMG were performed using cell monolayers, the in vitro pharmacological effects on 3D cancer models have never been investigated. Aim of the present study was to find new anticancer properties of αMG by evaluating the changes that this compound provokes in multicellular tumour spheroids (MCTSs). Methods: MCTSs were generated from MDA-MB-231 and MCF-7 breast tumour cell lines and then treated with 0...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29333032/macrodystrophia-lipomatosa-clinico-patho-radiological-correlation
#13
Rakesh Mehra, Richa Bhartiya, Pallavi Agrawal, Nawanita Kumari
Macrodystrophia lipomatosa is a rare congenital nonhereditary developmental anomaly. It is characterized by hamartomatous proliferation of the soft tissue leading to disproportionate enlargement of the limbs and digits. Since it leads to diagnostic dilemma, it has to be differentiated from various other conditions as they differ in course, prognosis, complications, and treatment. Herein, we present two cases with localized gigantism and discuss the various differential diagnoses and need for clinico-patho-radilogical correlation for diagnosis of this rare entity...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29332865/fibrillar-architecture-at-three-different-sites-of-the-bovine-superficial-digital-flexor-tendon
#14
Naoki Takahashi, Takuya Hirose, Jun A Minaguchi, Hiromi Ueda, Prasarn Tangkawattana, Kazushige Takehana
Superficial digital flexor tendon (SDFT) of the bovine hindlimb originates from the caudolateral aspect of the distal femur and finally inserts onto the plantar aspect of the middle phalanges. In the present study, morphology and morphometry of the bovine SDFT at the muscle-tendon junction (MTJ), middle metatarsus (mM) and tendon-bone interface (TBI) were investigated. Cross-sectional morphology at the three regions of SDFT were oval, semioval and ring-formed, respectively. Significant difference in cross-sectional area was found only between MTJ-mM and mM-TBI (P<0...
January 12, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29332805/trends-of-non-destructive-analytical-methods-for-identification-of-biodiesel-feedstock-in-diesel-biodiesel-blend-according-to-european-commission-directive-2012-0288-ec-and-detecting-diesel-biodiesel-blend-adulteration-a-brief-review
#15
REVIEW
Sarmento Júnior Mazivila
Discrimination of biodiesel feedstock present in diesel-biodiesel blend is challenging due to the great similarity in the spectral profile as well as digital image profile of each type of feedstock employed in biodiesel production. Once the marketed diesel-biodiesel blend is subsidized, in which motivates adulteration in biofuel blend by cheaper supplies with high solubility to obtain profits associated with the subsidies involved in biodiesel production. Non-destructive analytical methods based on qualitative and quantitative analysis for detecting marketed diesel-biodiesel blend adulteration are reviewed...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29332500/microstructure-and-mechanical-properties-of-porous-titanium-structures-fabricated-by-electron-beam-melting-for-cranial-implants
#16
Khaja Moiduddin
The traditional methods of metallic bone implants are often dense and suffer from adverse reactions, biomechanical mismatch and lack of adequate space for new bone tissue to grow into the implant. The objective of this study is to evaluate the customized porous cranial implant with mechanical properties closer to that of bone and to improve the aesthetic outcome in cranial surgery with precision fitting for a better quality of life. Two custom cranial implants (bulk and porous) are digitally designed based on the Digital Imaging and Communications in Medicine files and fabricated using additive manufacturing...
January 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29332423/first-experiences-with-a-wearable-multisensor-in-an-outpatient-glucose-monitoring-study-part-i-the-users-view
#17
Andreas Caduff, Mattia Zanon, Pavel Zakharov, Martin Mueller, Mark Talary, Achim Krebs, Werner A Stahel, Marc Donath
BACKGROUND: Extensive past work showed that noninvasive continuous glucose monitoring with a wearable Multisensor device worn on the upper arm provides useful information about glucose trends to improve diabetes therapy in controlled and semicontrolled conditions. METHODS: To test previous findings also in uncontrolled in-clinic and outpatient conditions, a long-term study has been conducted to collect Multisensor and reference glucose data in a population of 20 type 1 diabetes subjects...
January 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29332178/association-of-autism-with-maternal-infections-perinatal-and-other-risk-factors-a-case-control-study
#18
Dikran Richard Guisso, Fadi S Saadeh, Dahlia Saab, Joud El Deek, Sarah Chamseddine, Hadi Abou El Hassan, Ghidaa Majari, Rose-Mary Boustany
This case-control study explores the association between pregnancy/birth complications and other factors with Autism Spectrum Disorder (ASD) in Lebanese subjects aged 2-18 years. Researchers interviewed 136 ASD cases from the American University of Beirut Medical Center Special Kids Clinic, and 178 controls selected by systematic digit dialing in the Greater-Beirut area. Male gender (Adjusted Odds Ratio [95% CI]: 3.9 [2.2-7.0]); postpartum feeding difficulties (2.5 [1.2-5.4]); maternal infections/complications during pregnancy (2...
January 13, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29332057/evaluation-of-thickness-of-cad-cam-fabricated-zirconia-cores-by-digital-microscope
#19
Syed Rashid Habib, Asim Khaled Al Otaibi, Talal Ali Al Anazi, Samer Mosleh Al Anazi
Despite several advantages of digitalized workflow, researchers have noted discrepancies in the precision and trueness. This study investigated the accuracy in the final thickness of Zirconia (Zr) cores fabricated by five CAD/CAM systems. Standardized manufacturing of the cores with 1 mm thickness were carried out. Cores were then sectioned into two halves and measurement made with Digital Microscope at 5 points in micrometers. Overall, mean thickness for the groups was 1048.81 ± 94.01, which was 48 μm higher than the thickness programmed in the software...
December 29, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29332033/effect-of-dual-tasking-on-anticipatory-and-compensatory-postural-adjustments-in-response-to-external-perturbations-in-individuals-with-nonspecific-chronic-low-back-pain-electromyographic-analysis
#20
Ladan Hemmati, Soraya Piroozi, Zahra Rojhani-Shirazi
BACKGROUND: In patients with chronic low back pain (CLBP), postural control is a demanding task in terms of attention. Although the attentional demands of postural control have been investigated in these patients, the attentional demands of postural recovery during dual task performance have not been evaluated in patients with nonspecific CLBP. OBJECTIVE: To investigate the effect of dual tasking on anticipatory and compensatory postural adjustments in response to an external perturbation in patients with nonspecific CLBP...
December 29, 2017: Journal of Back and Musculoskeletal Rehabilitation
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