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Chihao Shao, Wenzhu Dai, Haili Li, Wenru Tang, Shuting Jia, Xiaoming Wu, Ying Luo
BACKGROUND: The function of the tumor suppressor gene RASSF1A in cancer cells has been detailed in many studies. However, due to the methylation of its promoter, the expression of RASSF1A is missing in most cancers. In the literature, we found that the conclusion regarding the relationship between RASSF1A gene promoter methylation and the susceptibility and prognosis of melanoma was not unified. This study adopts the use of a meta-analysis and bioinformatics to explore the relationship between RASSF1A gene promoter methylation and the susceptibility and prognosis of melanoma...
2017: PloS One
Salim S Hayek, Yi-An Ko, Mosaab Awad, Andrea Del Mar Soto, Hina Ahmed, Keyur Patel, Michael Yuan, Spencer Maddox, Brandon Gray, Jamal Hajjari, Laurence Sperling, Amit Shah, Viola Vaccarino, Arshed A Quyyumi
BACKGROUND: Depression is common in patients with coronary artery disease (CAD) and is associated with more frequent chest pain. It is however unclear whether this is due to differences in underlying CAD severity. We sought to determine [1] whether depressive symptoms are associated with chest pain independently of CAD severity, [2] whether improvement in depressive symptoms over time is associated with improvement in chest pain and [3] whether the impact of revascularization on chest pain differs between patients with and without depression...
March 1, 2017: International Journal of Cardiology
Sharon H Giordano, Jiangong Niu, Mariana Chavez-MacGregor, Hui Zhao, Daria Zorzi, Ya-Chen Tina Shih, Benjamin D Smith, Chan Shen
BACKGROUND: One goal for high-quality patient care is communicating treatment costs to patients, yet cost information can be elusive. This is especially relevant for breast cancer care, for which numerous guideline-concordant adjuvant chemotherapy regimens exist. The objective of the current study was to generate cost estimates for such regimens from payers' and patients' perspectives in a large, insured US population. METHODS: Adult women who had incident breast cancer diagnosed between 2008 and 2012 (from the MarketScan database), had no secondary malignancy within 1 year of diagnosis, and received chemotherapy within 3 months of diagnosis were included (n = 14,643)...
October 10, 2016: Cancer
Pei-Shan Tsai, I-Chao Liu, Chen-Huan Chiu, Chun-Jen Huang, Mei-Yeh Wang
BACKGROUND: Valproic acid (VPA) is widely used for treating patients with bipolar disorder; however, it has adverse effects on cognitive function. This study investigated the effect of VPA on the risk of dementia in patients with bipolar disorder. METHODS: We analyzed data from Taiwan's Longitudinal Health Insurance Database 2010. Patients with bipolar disorder who were prescribed VPA for 28 days or at least once per month for 3 consecutive months after the index date were classified as the VPA-treated group, whereas those who did not receive VPA were classified as the VPA-untreated group...
September 1, 2016: Journal of Affective Disorders
Shumin Bao, Wen Huang, Yuanbo Liang, Liping Jiang, Fenghua Wang, Yi Peng, Guangjuan Zhang, Ningli Wang
Few studies have examined the relationship between retinal microvascular abnormalities and chronic kidney disease (CKD). This study aims to examine the association between retinal vessel diameters and CKD in the rural China in order to provide the scientific basis for the early detection and diagnosis for CKD.Participants and data were extracted from the Handan Eye Study, a population-based cross-sectional study performed from 2006 to 2007. The central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were summarized by the average arteriolar and venular caliber of each eye...
December 2015: Medicine (Baltimore)
Isabelle Gingras, Christine Desmedt, Michail Ignatiadis, Christos Sotiriou
Desmedt and colleagues published two articles, one in the June 1, 2007 issue, and the other in the August 15, 2008, issue of Clinical Cancer Research, that showed gene-expression signatures to be proliferation driven and time dependent, with their prognostic power decreasing with increasing follow-up years. Moreover, the articles showed that immune response is a crucial determinant of prognosis in the HER2-positive and estrogen receptor-negative/HER2-negative subtypes, providing a rationale to further explore the role of the antitumor immune response in these breast cancer subtypes...
November 1, 2015: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Desiree Van Haute, Julia M Longmate, Jacob M Berlin
Nanoparticle assembly is of importance for applications ranging from medical diagnostics to solar panels. On page 5158, J. M. Berlin and co-workers report that the use of a small molecule crosslinker allows for control of metallic nanoparticle assembly in a fashion analogous to polymerization reactions. The size of the assembled aggregates can be tuned, and they are highly homogeneous, stable, and biocompatible.
September 2015: Advanced Materials
Lianlian Wang, Jingxi Li, Zhan Shi
Quantification of the association between breastfeeding and risk of endometrial cancer is still conflicting. We therefore conducted a meta-analysis to assess the association between breastfeeding and endometrial cancer risk. Pertinent studies were identified by a search of PubMed and Web of Knowledge through April 2015. A random effect model was used to combine the data for analysis. Sensitivity analysis and publication bias were conducted. Dose-response relationships were assessed by restricted cubic spline and variance-weighted least squares regression analysis...
July 2015: Nutrients
A J Aho, K Kamata, V Jäntti, A Kulkas, S Hagihira, H Huhtala, A Yli-Hankala
BACKGROUND: Concomitantly recorded Bispectral Index® (BIS) and Entropy™ values sometimes show discordant trends during general anaesthesia. Previously, no attempt had been made to discover which EEG characteristics cause discrepancies between BIS and Entropy. We compared BIS and Entropy values, and analysed the changes in the raw EEG signal during surgical anaesthesia with sevoflurane. METHODS: In this prospective, open-label study, 65 patients receiving general anaesthesia with sevoflurane were enrolled...
August 2015: British Journal of Anaesthesia
Lifeng Lao, Jeremiah R Cohen, Elizabeth L Lord, Zorica Buser, Jeffrey C Wang
PURPOSE: A retrospective database review was carried out to evaluate the trends and demographics of rhBMP utilization in single-level posterior lumbar fusion (PLF) in the United States. METHODS: Patients who underwent single-level PLF from 2005 to 2011 were identified by searching ICD-9 diagnosis and procedure codes in the PearlDiver Patient Records Database (PearlDiver Technologies, Fort Wayne, IN, USA), a national database of orthopaedic insurance records. The year of procedure, age, gender, and region of the United States were recorded for each patient...
March 2016: European Spine Journal
D Girard, D Antoine, D Che
OBJECTIVE: In France, tuberculosis surveillance is based on mandatory notification (MN) of cases. However, the MN does not allow the full description of cases, and underreporting limits data interpretation. Aiming at better describing the cases of tuberculosis, the hospital record database (PMSI) was analyzed. PATIENTS AND METHOD: Incident cases of active pulmonary tuberculosis identified in 2010 in France in the PMSI were included and their characteristics were compared with those of the cases identified through the MN...
December 2014: Médecine et Maladies Infectieuses
Aman P K Nijjar, Hong Wang, Hude Quan, Nadia A Khan
OBJECTIVE: Type 2 diabetes mellitus is a clear prognostic marker for increased cardiovascular morbidity and mortality after acute myocardial infarction (AMI). We compared diabetes patients based on therapy used (no pharmacotherapy, those prescribed oral antihyperglycemic agents and those prescribed insulin) on the composite risk of recurrent AMI, congestive heart failure and mortality among elderly patients with AMI. METHODS: Using administrative data, we identified patients, aged 65 years and older, with an incident AMI hospitalization in British Columbia and the Calgary Health Region between April 1, 1995, and March 31, 2002, for a retrospective cohort study...
December 2014: Canadian Journal of Diabetes
R Fatima, E Qadeer, D A Enarson, J Creswell, R H Stevens, R Stevens, S G Hinderaker, K Anwar, M ul Haq
BACKGROUND: In Pakistan, patients with symptoms suggestive of tuberculosis (TB) seek care from a wide array of health care providers, many of whom do not notify cases to the National TB Programme (NTP). SETTING: We evaluated an active case detection intervention in five randomly selected districts in urban slums of Sindh Province, Pakistan. OBJECTIVE: To evaluate the increase in case notification of smear-positive TB by active case finding at community-based chest camps by engaging the private providers...
September 2014: International Journal of Tuberculosis and Lung Disease
X L Yang, J Tian, Y Liang, C J Ma, A N Yang, J Wang, S C Ma, Y Cheng, X Hua, Y D Jiang
Homocysteine (Hcy) is an independent risk factor of atherosclerosis through its involvement with the methionine cycle. In this study, we aimed to determine the blood vessel global methylation rate in Hcy-induced atherosclerosis in apolipoprotein-E-deficient (ApoE-/-) mice, and to explore the possible mechanism of this change in endothelial cells. ApoE-/- mice were divided into a hyperlipidemia (HLP) group, a hyperhomocysteinemia (HHcy) group, and an HHcy + folate + vitamin B12 (HHcy+FA+VB) group. Wild-type C57BL/6J mice were prepared as controls...
2014: Genetics and Molecular Research: GMR
Silvano Gallus, Alessandra Lugo, Simone Ghislandi, Carlo La Vecchia, Anna B Gilmore
Excise duties on roll-your-own (RYO) tobacco, which are generally based on RYO cigarettes containing 1 g of tobacco, are lower than duties on factory-made (FM) cigarettes. This provides a price incentive for smokers to switch to RYO, the use of which is increasing across Europe. To effectively approximate duties on the two types of products, accurate data on the weight of RYO cigarettes are required. We provide updated information on RYO use and RYO cigarette weight across Europe. From a representative face-to-face survey conducted in 2010 in 18 European countries (Albania, Austria, Bulgaria, Czech Republic, Croatia, England, Finland, France, Greece, Hungary, Ireland, Italy, Latvia, Poland, Portugal, Romania, Spain and Sweden), we considered data from 5158 current smokers aged 15 years or above, with available information on daily consumption of FM and RYO cigarettes separately...
May 2014: European Journal of Cancer Prevention
Ryan Mills, Rosa Alati, Lane Strathearn, Jake M Najman
AIMS: This study examines whether child maltreatment experience predicts adolescent tobacco and alcohol use. METHODS: The subjects were participants in the Mater-University Study of Pregnancy (MUSP), a birth cohort of 7223, of whom 5158 (71.4%) were available for analysis at the 14-year follow-up. Child protection history was obtained from the state's child protection agency and confidentially linked. Exposure to reported child maltreatment was the primary predictor variable...
April 2014: Addiction
Onikepe Owolabi, Zhenzhen Zhang, Xiaolin Wei, Nan Yang, Haitao Li, Samuel Y S Wong, Martin C S Wong, Winnie Yip, Sian M Griffiths
BACKGROUND: Strengthening primary care is key to Hong Kong's ongoing health system reform. Primary care remains unregulated, private sector dominated and financed mainly out-of-pocket. This study sought to examine the association between patients' socioeconomic status (SES), source of health payments and the quality of primary care they accessed to inform policy discussions. METHODS: Data was collected from 1,994 respondents in a stratified random telephone survey with a 68% response rate, using the validated primary care assessment tool (PCAT)...
2013: BMC Health Services Research
Xian-Juan Feng, Yurii Prots, Marcus Peter Schmidt, Stefan Hoffmann, Igor Veremchuk, Walter Schnelle, Ulrich Burkhardt, Jing-Tai Zhao, Yuri Grin
Two atomic arrangements were found near the equiatomic composition in the strontium-lithium-arsenic system. Orthorhombic o-SrLiAs was synthesized by reaction of elemental components at 950 °C, followed by annealing at 800 °C and subsequent quenching in water. The hexagonal modification h-SrLi(1-x)As was obtained from annealing of o-SrLiAs at 550 °C in dynamic vacuum. The structures of both phases were determined by single-crystal X-ray diffraction: o-SrLiAs, structure type TiNiSi, space group Pnma, Pearson symbol oP12, a = 7...
August 5, 2013: Inorganic Chemistry
Jeremy K Brown, Katarina B Lauer, Emily L Ironmonger, Neil F Inglis, Tom H Bourne, Hilary O D Critchley, Andrew W Horne
Ectopic pregnancy (EP) is difficult to diagnose early and accurately. Women often present at emergency departments in early pregnancy with a 'pregnancy of unknown location' (PUL), and diagnosis and exclusion of EP is challenging due to a lack of reliable biomarkers. The objective of this study was to identify novel diagnostic biomarkers for EP. Shotgun proteomics, incorporating combinatorial-ligand library pre-fractionation, was used to interrogate pooled sera (n = 40) from women undergoing surgery for EP, termination of viable intrauterine pregnancy and management of non-viable intrauterine pregnancy...
2013: PloS One
Susmita Chatterjee, Ramanan Laxminarayan
OBJECTIVE: Despite a growing volume of surgical procedures in low-income and middle-income countries, the costs of these procedures are not well understood. We estimated the costs of 12 surgical procedures commonly conducted in five different types of hospitals in India from the provider perspective, using a microcosting method. DESIGN: Cost and utilisation data were collected retrospectively from April 2010 to March 2011 to avoid seasonal variability. SETTING: For this study, we chose five hospitals of different types: a 57-bed charitable hospital, a 200-bed private hospital, a 400-bed district hospital, a 655-bed private teaching hospital and a 778-bed tertiary care teaching hospital based on their willingness to cooperate and data accessibility...
2013: BMJ Open
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