keyword
MENU ▼
Read by QxMD icon Read
search

Centralization

keyword
https://www.readbyqxmd.com/read/28945060/benefits-of-micronized-purified-flavonoid-fraction-as-adjuvant-therapy-on-the-inflammatory-response-after-sclerotherapy
#1
Vadim Y Bogachev, Boris V Boldin, Victor N Lobanov
BACKGROUND: Sclerotherapy is the treatment of choice for telangiectasias. The aim of this study was to investigate the systemic and local inflammatory response after sclerotherapy in women with chronic venous disease (CVD) and to assess the effects of micronized purified flavonoid fraction (MPFF) in combination with sclerotherapy on markers of inflammation and endothelial dysfunction. METHODS: 60 women with primary CVD CEAP class C1 were randomly assigned sclerotherapy in combination with MPFF treatment (N=30) or sclerotherapy alone (control) group (N=30)...
September 22, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28945055/adjuvant-treatments-for-ependymomas
#2
E Alton Sartor, Patrick Y Wen
Ependymomas are rare primary central nervous system tumors occurring in children and young adults. They can be indolent or locally aggressive depending on location, histology, and extent of resection. Treatment involves maximal surgical resection and usually focal radiation therapy, depending on the presence of residual disease and tumor grade. Chemotherapy has been studied for both adults and children but do not have an established role in adjuvant therapy. In both age groups, treatment with mainly cisplatin based regimens can be considered in the setting of residual disease after surgery or for salvage therapy when surgery or further radiation is not indicated...
September 22, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28945018/-expert-consensus-on-the-design-and-implementation-of-clinical-safety-centralized-monitoring-study-of-chinese-medical-injection
#3
Jun-Hua Zhang, Jing-Tian Ren, Jing-Qing Hu, Yan-Ming Xie, Hai-Bo Song, Ming-Jun Zhu, Rui Gao, Zhong Wang, Wen-Ke Zheng, Xue-Lin Li, Meng Jiang, Yu-Hong Huang, Fang Lu, Li-Yun He, Wei-Xiong Lian, Zhong-Qi Yang, Wei-An Yuan, Si-Yuan Hu, Bao-He Wang, Wei-Liang Wang, De-Quan Ren, Bo-Li Zhang
Along with the increase of clinical application, the safety of traditional Chinese medicine gained more and more attentions. In particular, the safety evaluation of Chinese medical injections has become a mandatory task should be completed by pharmaceutical companies under the supervision of China Food and Drug Administration(CFDA). Due to the weak foundation of previous studies, the safety issues of Chinese medical injections have not been fully understood, and lack of scientific and rational risk management programs...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28944988/evaluation-and-treatment-of-langerhans-cell-histiocytosis-patients-with-central-nervous-system-abnormalities-current-views-and-new-vistas
#4
REVIEW
E Ann Yeh, Jay Greenberg, Oussama Abla, Giulia Longoni, Eli Diamond, Michelle Hermiston, Brandon Tran, Carlos Rodriguez-Galindo, Carl E Allen, Kenneth L McClain
Central nervous system (CNS) involvement in Langerhans cell histiocytosis (LCH) can include mass lesions of the hypothalamic pituitary axis, choroid plexus, cerebrum, and cerebellum or magnetic resonance imaging (MRI) signal abnormalities of the cerebellum, pons, and basal ganglia. The term neurodegenerative (ND) CNS-LCH has been given to the MRI signal abnormalities and neurologic dysfunction, although initially patients may have no clinical symptoms. Standardized evaluations to better understand the natural history and response to therapy are needed...
September 25, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28944982/evaluation-of-inos-inhibition-on-kidney-function-and-structure-in-high-fat-diet-induced-kidney-disease
#5
Blanche Martin, Nathalie Caron, Inès Jadot, Vanessa Colombaro, Gabrielle Federici, Clara Depommier, Anne-Émilie Declèves
BACKGROUND: Central obesity is related to caloric excess promoting deleterious cellular responses in targeted organs. Nitric oxide (NO) has been determined as a key player in the pathogenesis of metabolic diseases. Here, we investigated the implication of inducible NO synthase (iNOS) in the development of obesity-induced kidney disease. MATERIALS AND METHODS: C57Bl/6 male mice were randomized to a low-fat diet (LFD) or a high-fat diet (HFD) and treated with L-NIL, a specific iNOS inhibitor for 16 weeks...
September 25, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28944742/in-situ-delivery-of-corticosteroids-for-treatment-of-oral-diseases
#6
Viviana De Caro, Flavia Maria Sutera, Libero Italo Giannola
In many mucocutaneous disorders, corticosteroids therapy is currently central. Systemic therapy is restricted to severe disorders whereas topical applications are considered as the first-line treatment. The oral cavity environment, the medication form and other factors related to the delivery method are key factors for the therapy efficiency and effectiveness. Current marketed medications are not able to avoid wrong drug exposure and scarce patients' compliance. Innovative in situ delivery systems are able to prolong the drug retention time on the mucosa and to avoid the drawbacks of conventional formulations...
October 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28944671/prioritizing-popular-proteins-in-liver-cancer-remodelling-one-carbon-metabolism
#7
María Isabel Mora, Manuela Molina, Leticia Odriozola, Felix Elortza, Jose M Mato, Barbara Sitek, Pumin Zhang, Fuchu He, Maria Uxue Latasa, Matías Avila, Fernando Corrales
Primary liver cancer (HCC) is recognized as the fifth most common neoplasm and the second leading cause of cancer deaths worldwide. Most risk factors are known and the molecular pathogenesis has been widely studied in the last decade; however, the underlying molecular mechanisms remain to be unveiled, as they will facilitate definition of novel biomarkers and clinical targets for more effective patient management. In this study, we utilize the B/D-HPP popular protein strategy. We report a list of popular proteins that have been highly co-cited with the expression "liver cancer"...
September 25, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28944652/droplet-guiding-superhydrophobic-arrays-of-plasmonic-microposts-for-molecular-concentration-and-detection
#8
Hyelim Kang, Yongjoon Heo, Dong Jae Kim, Ju Hyeon Kim, Tae Yoon Jeon, Soojeong Cho, Hye-Mi So, Won Seok Chang, Shin-Hyun Kim
Droplet-guiding superhydrophobic SERS substrates are created by a combinatorial lithographic technique. Photolithography defines the pattern of a micropillar array with a radial density gradient, whereas colloidal lithography features a nanotip array on the top surface of each micropillar. The nanotip array renders the surface superhydrophobic and the pattern of micropillars endows the radial gradient of contact angle, enabling the spontaneous droplet migration toward the center of the pattern. Water droplets containing target molecules are guided to the center and the molecules dissolved in the droplets are concentrated at the surface of the central micropillar during droplet evaporation...
September 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28944610/last-century-forest-productivity-in-a-managed-dry-edge-scots-pine-population-the-two-sides-of-climate-warming
#9
Laura Marqués, Jaime Madrigal-González, Miguel A Zavala, J Julio Camarero, Florian Hartig
Climate change in the Mediterranean, associated with warmer temperatures and more frequent droughts, is expected to impact forest productivity and the functioning of forests ecosystems as carbon reservoirs in the region. Climate warming can positively affect forest growth by extending the growing season, whereas increasing summer drought generally reduces forest productivity and may cause growth decline, trigger dieback, hamper regeneration and increase mortality. Forest management could potentially counteract such negative effects by reducing stand density and thereby competition for water...
September 25, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28944578/impact-of-a-central-scaffold-on-the-binding-affinity-of-fragment-pairs-isolated-from-dna-encoded-self-assembling-chemical-libraries
#10
Martina Bigatti, Alberto Dal Corso, Sara Vanetti, Samuele Cazzamalli, Ulrike Rieder, Jörg Scheuermann, Dario Neri, Filippo Sladojevich
The screening of encoded self-assembling chemical libraries allows the identification of fragment pairs that bind to adjacent pockets on target proteins of interest. For practical applications, it is necessary to link these ligand pairs into discrete organic molecules, devoid of any nucleic acid component. Here we describe the discovery of a synergistic binding pair for acid alpha-1 glycoprotein and a chemical strategy for the identification of optimal linkers, connecting the two fragments. The procedure yielded a set of small organic ligands, the best of which exhibited a dissociation constant of 9...
September 24, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28944558/imaging-the-neuroimmune-response-to-alcohol-exposure-in-adolescent-baboons-a-tspo-pet-study-using-18-f-dpa-714
#11
Wadad Saba, Sébastien Goutal, Sylvain Auvity, Bertrand Kuhnast, Christine Coulon, Virginie Kouyoumdjian, Irène Buvat, Claire Leroy, Nicolas Tournier
The effects of acute alcohol exposure to the central nervous system are hypothesized to involve the innate immune system. The neuroimmune response to an initial and acute alcohol exposure was investigated using translocator protein 18 kDa (TSPO) PET imaging, a non-invasive marker of glial activation, in adolescent baboons. Three different alcohol-naive adolescent baboons (3-4 years old, 9 to 14 kg) underwent (18) F-DPA-714 PET experiments before, during and 7-12 months after this initial alcohol exposure (0...
September 25, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28944540/three-atcesa6-like-members-enhance-biomass-production-by-distinctively-promoting-cell-growth-in-arabidopsis
#12
Huizhen Hu, Ran Zhang, Shengqiu Feng, Youmei Wang, Yanting Wang, Chunfen Fan, Ying Li, Zengyu Liu, René Schneider, Tao Xia, Shi-You Ding, Staffan Persson, Liangcai Peng
Cellulose is an abundant biopolymer and a prominent constituent of plant cell walls. Cellulose is also a central component to plant morphogenesis and contributes the bulk of a plant's biomass. While cellulose synthase (CesA) genes were identified over two decades ago, genetic manipulation of this family to enhance cellulose production has remained difficult. In this study, we show that increasing the expression levels of the three primary cell wall AtCesA6-like genes (AtCesA2, -5, -6), but not AtCesA3, AtCesA9 or secondary cell wall AtCesA7, can promote the expression of major primary wall CesA genes to accelerate primary wall CesA complex (CSCs) particle movement for acquiring long microfibrils and consequently increasing cellulose production in Arabidopsis transgenic lines, as compared with wild type...
September 25, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28944505/taxonomy-of-cns-tumours-a-series-of-three-short-reviews-on-the-who-2016-classification-and-beyond
#13
EDITORIAL
Pieter Wesseling, Thomas S Jacques
In May 2016, an update of the 4th edition of the World Health Organization (WHO) Classification of Tumours of the Central Nervous System (CNS) was officially released [1]. This revised 4th edition represents a paradigm shift as, for the first time, the definition of multiple CNS tumour entities is now partly based on particular genotypic characteristics. Additionally, compared to the 4th edition (published in 2007), some splitting and lumping of entities occurred because of new insights in the genetic underpinnings of CNS tumours and/or based on more recently published clinico-pathologic studies...
September 25, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28944479/temporal-horizontal-h-figure-sliding-skin-flap-for-central-eyelid-reconstructive-surgery-in-dogs-a-retrospective-study
#14
C Giordano, A Vercelli, G Barsotti
OBJECTIVE: To describe a modified H-figure sliding skin flap for treating eyelid central neoplasms and to evaluate the cosmetic and functional results of this reconstructive blepharoplasty. MATERIAL AND METHODS: Eight dogs affected by eyelid neoplasia involving more than one-third of the central part of the margin underwent an en bloc rectangular surgical removal of the neoplasia. Reconstructive surgery was performed using a temporal horizontal H-figure sliding skin flap...
September 25, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28944453/personalised-digital-interventions-for-reducing-hazardous-and-harmful-alcohol-consumption-in-community-dwelling-populations
#15
REVIEW
Eileen Fs Kaner, Fiona R Beyer, Claire Garnett, David Crane, Jamie Brown, Colin Muirhead, James Redmore, Amy O'Donnell, James J Newham, Frank de Vocht, Matthew Hickman, Heather Brown, Gregory Maniatopoulos, Susan Michie
BACKGROUND: Excessive alcohol use contributes significantly to physical and psychological illness, injury and death, and a wide array of social harm in all age groups. A proven strategy for reducing excessive alcohol consumption levels is to offer a brief conversation-based intervention in primary care settings, but more recent technological innovations have enabled people to interact directly via computer, mobile device or smartphone with digital interventions designed to address problem alcohol consumption...
September 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28944408/etiology-of-childhood-pneumonia-what-we-know-and-what-we-need-to-know-based-on-5th-dr-ic-verma-excellence-oration-award
#16
Joseph L Mathew
Childhood community acquired pneumonia continues to be an important clinical problem at the individual, institutional and community levels. Determination of microbial etiology is critical to develop evidence-based management (therapeutic and prophylactic) decisions. For decades, the approach to this relied on culture of lung aspirate specimens obtained from children with radiographically confirmed pneumonia, before administering antibiotics. Such studies revealed the major bacteria associated with pneumonia, prompting the World Health Organization to develop a highly sensitive clinical definition of pneumonia and advocate empiric antibiotic therapy; in order to save lives (focusing on community settings lacking resources for diagnostic tests)...
September 25, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28944390/a-topological-study-of-chemical-bonds-under-pressure-solid-hydrogen-as-a-model-case
#17
Vanessa Riffet, Vanessa Labet, Julia Contreras-García
It is now well recognized that a fundamental understanding of the rules that govern chemistry under pressure is still lacking. Hydrogen being the "simplest" element as well as a central core to high pressure physics, we undertake a general study of the changes in the chemical bonding under pressure. We start from a simple trimer unit that has been found in high pressure phases, whose behavior has been found to reveal the basics of hydrogen polymerization under pressure. Making use of bond analysis tools, mainly the NCI (noncovalent interactions) index, we show that polymerization takes place in three steps: dipolar attraction, repulsion and bond formation...
September 25, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28944371/prosthetic-protocols-in-implant-based-oral-rehabilitations-a-systematic-review-on-the-clinical-outcome-of-monolithic-all-ceramic-single-and-multi-unit-prostheses
#18
Frank A Spitznagel, Sebastian D Horvath, Petra C Gierthmuehlen
AIM: The purpose of this systematic review was to assess the clinical performance of implant-supported monolithic all-ceramic single- and multi-unit restorations. MATERIALS AND METHODS: The electronic databases of MEDLINE via PubMed, the Cochrane Library (CENTRAL) and EMBASE were searched for clinical studies on monolithic all-ceramic single and multi-unit implant-supported fixed dental prostheses. Human studies with a mean follow-up of at least 2 years and published in English or German language peer-reviewed journals up until August 2016 were included...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/28944304/wearable-technology-to-reduce-sedentary-behavior-and-cvd-risk-in-older-adults-design-of-a-randomized-controlled-trial
#19
Lisa M Krehbiel, Andrew S Layne, Bhanuprasad Sandesara, Todd M Manini, Stephen D Anton, Thomas W Buford
Persons aged over 65 years account for over the vast majority of healthcare expenditures and deaths attributable to cardiovascular disease (CVD). Accordingly, reducing CVD risk among older adults is an important public health priority. Structured physical activity (i.e. exercise) is a well-documented method of decreasing CVD risk, but recent large-scale trials suggest that exercise alone is insufficient to reduce CVD events in high-risk populations of older adults. Thus adjuvant strategies appear necessary to reduce CVD risk...
June 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/28944213/comment-on-predictors-of-short-term-outcomes-related-to-central-subfield-foveal-thickness-after-intravitreal-bevacizumab-for-macular-edema-due-to-central-retinal-vein-occlusion
#20
Dan Călugăru, Mihai Călugăru
No abstract text is available yet for this article.
2017: International Journal of Ophthalmology
keyword
keyword
3002
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"