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https://www.readbyqxmd.com/read/28738652/volatile-composition-of-merlot-red-wine-and-its-contribution-to-the-aroma-optimization-and-validation-of-analytical-method
#1
Stefany Grützmann Arcari, Vinicius Caliari, Marla Sganzerla, Helena Teixeira Godoy
A methodology for the determination of volatile compounds in red wine using headspace solid phase microextraction (HS-SPME) combined with gas chromatography-ion trap/ mass spectrometry (GC-IT/MS) and flame ionization detector (GC -FID) was developed, validated and applied to a sample of Brazilian red wine. The optimization strategy was conducted using the Plackett-Burman design for variable selection and central composite rotational design (CCRD). The response surface methodology showed that the performance of the extraction of the volatile compounds using divinylbenzene/carboxen/polydimethylsiloxane (DVB/CAR/PDMS) fiber is improved with no sample dilution, the addition of 30% NaCl, applying an extraction temperature of 56°C and extraction time of 55min...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738469/-analysis-on-geographic-distribution-of-high-blood-pressure-prevalence-in-children-and-adolescents-aged-7-18-years-in-china-2014
#2
Y H Dong, Z Y Zou, Z H Wang, S Wang, Z P Yang, Y J Chen, J Ma
Objective: To understand and evaluate the characteristics of geographic distribution of high blood pressure prevalence in children and adolescents aged 7-18 years in China in 2014, and provide evidence for the prevention of hypertension in children and adolescents. Methods: The data of 2014 Chinese National Surveys on Students Constitution and Health conducting 31 provinces (except Hong Kong, Macao and Taiwan) were collected. A total of 216 299 children and adolescents who had complete blood pressure records were selected as study subjects...
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28738459/-gene-gene-interaction-on-central-obesity-in-school-aged-children-in-china
#3
L W Fu, M X Zhang, L J Wu, L W Gao, J Mi
Objective: To investigate possible effect of 6 obesity-associated SNPs in contribution to central obesity and examine whether there is an interaction in the 6 SNPs in the cause of central obesity in school-aged children in China. Methods: A total of 3 502 school-aged children who were included in Beijing Child and Adolescent Metabolic Syndrome (BCAMS) Study were selected, and based on the age and sex specific waist circumference (WC) standards in the BCAMS study, 1 196 central obese cases and 2 306 controls were identified...
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28738389/pdgf-promotes-the-warburg-effect-in-pulmonary-arterial-smooth-muscle-cells-via-activation-of-the-pi3k-akt-mtor-hif-1%C3%AE-signaling-pathway
#4
Yunbin Xiao, Hongyan Peng, Chenliang Hong, Zhi Chen, Xicheng Deng, Aiping Wang, Fang Yang, Li Yang, Chen Chen, Xuping Qin
BACKGROUND/AIMS: The enhanced proliferation of pulmonary arterial smooth muscle cells (PASMCs) is a central pathological component in pulmonary arterial hypertension (PAH). Both the Warburg effect and platelet-derived growth factor (PDGF) are involved in the proliferation of PASMCs. However, the mechanism underlying the crosstalk between the Warburg effect and PDGF during PASMC proliferation is still unknown. We hypothesized that PDGF promotes the Warburg effect via activating the phosphatidylinositol 3-kinase (PI3K) signaling pathway and hypoxia-inducible factor 1-α (HIF-1α) in proliferative PASMCs...
July 24, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28738359/predictors-of-subclinical-inflammatory-obesity-plasma-levels-of-leptin-very-low-density-lipoprotein-cholesterol-and-cd14-expression-of-cd16-monocytes
#5
Fernanda Leite, Ângela Leite, Ana Santos, Margarida Lima, Joselina Barbosa, Marco Cosentino, Laura Ribeiro
OBJECTIVE: Predictors of subclinical inflammatory obesity (SIO) can be important tools for early therapeutic interventions in obesity-related comorbidities. Waist circumference (WC) and BMI have different SIO sensitivity. We aimed to i) identify SIO predictors and ii) investigate whether CD16+ monocytes are associated with BMI- (generally) or WC-defined (centrally) obesity. METHODS: Anthropometric and metabolic/endocrine (namely catecholamines, adrenaline and noradrenaline) parameters were evaluated, and CD16+ monocytes were studied by flow cytometry in the peripheral blood from 63 blood donors, and compared and correlated to each other...
July 22, 2017: Obesity Facts
https://www.readbyqxmd.com/read/28738268/descriptive-epidemiology-of-primary-malignant-and-non-malignant-central-nervous-tumors-in-spain-results-from-the-girona-cancer-registry-1994-2013
#6
Rafael Fuentes-Raspall, Marta Solans, Aina Roca-Barceló, Loreto Vilardell, Montse Puigdemont, Sonia Del Barco, Raquel Comas, Adelaida García-Velasco, Aurora Astudillo, Mª Carme Carmona-Garcia, Rafael Marcos-Gragera
BACKGROUND: Systematic registration of non-malignant central nervous system (CNS) tumors is a rare practice among European cancer registries. Thus, the real burden of all CNS tumors across Europe is underestimated. The Girona Cancer Registry provides here the first data on CNS tumor incidence and survival trends in Spain for all histological types, including malignant and non-malignant tumors. METHODS: Data on all incident cases of primary CNS tumors notified to the Girona population-based cancer registry from 1994 to 2013 (n=2,131) were reviewed...
July 21, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28738262/systematic-review-of-community-health-impacts-of-mountaintop-removal-mining
#7
REVIEW
Abee L Boyles, Robyn B Blain, Johanna R Rochester, Raghavendhran Avanasi, Susan B Goldhaber, Sofie McComb, Stephanie D Holmgren, Scott A Masten, Kristina A Thayer
BACKGROUND: The objective of this evaluation is to understand the human health impacts of mountaintop removal (MTR) mining, the major method of coal mining in and around Central Appalachia. MTR mining impacts the air, water, and soil and raises concerns about potential adverse health effects in neighboring communities; exposures associated with MTR mining include particulate matter (PM), polycyclic aromatic hydrocarbons (PAHs), metals, hydrogen sulfide, and other recognized harmful substances...
July 21, 2017: Environment International
https://www.readbyqxmd.com/read/28738173/simulating-the-meteorology-and-pm10-concentrations-in-arizona-dust-storms-with-the-weather-research-and-forecasting-model-with-chemistry-wrf-chem
#8
Peter Hyde, Alex Mahalov, Jialun Li
Nine dust storms in south-central Arizona, USA were simulated with the Weather Research and Forecasting with Chemistry model (WRF-Chem) at 2-km resolution. The windblown dust emission algorithm was the Air Force Weather Agency model. In comparison with ground-based PM10 observations, the model unevenly reproduces the dust storm events. The model adequately estimates the location and timing of the events, but it is unable to precisely replicate the magnitude and timing of the elevated hourly concentrations of particles 10 microns and smaller ([PM10])...
July 24, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28738171/emerging-roles-for-tfeb-in-the-immune-response-and-inflammation
#9
Owen A Brady, José A Martina, Rosa Puertollano
Inflammation is a central feature of an effective immune response, which functions to eliminate pathogens and other foreign material, and promote recovery; however, dysregulation of the inflammatory response is associated with a wide variety of disease states. The autophagy-lysosome pathway is one of 2 major degradative pathways used by the cell and serves to eliminate long-lived and dysfunctional proteins and organelles to maintain homeostasis. Mounting evidence implicates the autophagy-lysosome pathway as a key player in regulating the inflammatory response; hence many inflammatory diseases may fundamentally be diseases of autophagy-lysosome pathway dysfunction...
July 24, 2017: Autophagy
https://www.readbyqxmd.com/read/28738165/physical-and-mechanical-therapies-for-lower-limb-problems-in-juvenile-idiopathic-arthritis-a-systematic-review-with-meta-analysis
#10
Antoni Fellas, Andrea Coda, Fiona Hawke
BACKGROUND: Juvenile Idiopathic Arthritis (JIA) is a chronic, autoimmune, inflammatory joint disease and is the most common arthritis affecting children under 16 years of age. Children with JIA commonly experience lower limb dysfunction and disability. OBJECTIVE: To systematically review the effectiveness of physical and mechanical therapies for lower limb problems JIA. METHODS: Randomised control trials (RCT) of physical and mechanical interventions for lower limb problems in children with JIA were included...
July 24, 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28738147/round-robin-study-molecular-simulation-of-thermodynamic-properties-from-models-with-internal-degrees-of-freedom
#11
Michael Schappals, Andreas Mecklenfeld, Leif Kröger, Vitalie Botan, Andreas Köster, Simon Stephan, Edder J García, Gabor Rutkai, Gabiele Raabe, Peter Klein, Kai Leonhard, Colin W Glass, Johannes Lenhard, Jadran Vrabec, Hans Hasse
Thermodynamic properties are often modeled by classical force fields which describe the interactions on the atomistic scale. Molecular simulations are used for retrieving thermodynamic data from such models and many simulation techniques and computer codes are available for that purpose. In the present round robin study, the following fundamental question is addressed: Will different user groups working with different simulation codes obtain coinciding results within the statistical uncertainty of their data? A set of 24 simple simulation tasks is defined and solved by five user groups working with eight molecular simulation codes: DL_POLY, GROMACS, IMC, LAMMPS, ms2, NAMD, Tinker, and TOWHEE...
July 24, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28738112/central-role-of-protein-kinase-a-in-promoting-trigeminal-nociception-in-an-in-vivo-model-of-temporomandibular-disorders
#12
Lindsey K Koop, Jordan L Hawkins, Lauren E Cornelison, Paul L Durham
AIMS: To investigate cellular changes in the spinal trigeminal nucleus (STN) and trigeminal ganglion (TG) associated with trigeminal nociception mediated by inflammation in the temporomandibular joint (TMJ). METHODS: Male Sprague-Dawley rats (n = 86) were utilized to investigate cellular and behavioral responses to prolonged TMJ inflammation caused by bilateral injection of Complete Freund's Adjuvant (CFA) in the TMJ capsules. To investigate the cellular effects of protein kinase A (PKA) in the STN, rats were injected intrathecally with the selective PKA inhibitor KT5720 prior to injection of CFA into both TMJ capsules...
July 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28738063/atypical-speech-versus-non-speech-detection-and-discrimination-in-4-to-6-yr-old-children-with-autism-spectrum-disorder-an-erp-study
#13
Alena Galilee, Chrysi Stefanidou, Joseph P McCleery
Previous event-related potential (ERP) research utilizing oddball stimulus paradigms suggests diminished processing of speech versus non-speech sounds in children with an Autism Spectrum Disorder (ASD). However, brain mechanisms underlying these speech processing abnormalities, and to what extent they are related to poor language abilities in this population remain unknown. In the current study, we utilized a novel paired repetition paradigm in order to investigate ERP responses associated with the detection and discrimination of speech and non-speech sounds in 4- to 6-year old children with ASD, compared with gender and verbal age matched controls...
2017: PloS One
https://www.readbyqxmd.com/read/28738010/effects-of-the-%C3%AE-2-adrenoceptor-agonist-medetomidine-on-the-distribution-and-clearance-of-alfaxalone-during-coadministration-by-constant-rate-infusion-in-dogs
#14
Rachel C Bennett, Kati M Salla, Marja R Raekallio, Mika Scheinin, Outi M Vainio
OBJECTIVE To assess the possible impact of medetomidine on concentrations of alfaxalone in plasma, when coadministered as a constant rate infusion (CRI) to dogs, and to determine the possible impact of medetomidine on the cardiopulmonary effects of alfaxalone during CRI. ANIMALS 8 healthy adult Beagles. PROCEDURES 3 treatments were administered in a randomized crossover design as follows: 1 = saline (0.9% NaCl) solution injection, followed in 10 minutes by induction of anesthesia with alfaxalone (loading dose, 2...
August 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28737909/inhibitory-kappa-b-kinse-%C3%AE-ikk%C3%AE-inhibitors-that-recapitulate-their-selectivity-in-cells-against-isoform-related-biomarkers
#15
Nahoum G Anthony, Jessica Baiget, Giacomo Berretta, Marie Boyd, David Breen, Joanne Edwards, Carly Gamble, Alexander I Gray, Alan L Harvey, Sophia Hatziieremia, Ka Ho Ho, Judith K Huggan, Stuart Lang, Sabin Llona-Minguez, Jia Lin Luo, Kathryn McIntosh, Andrew Paul, Robin J Plevin, Murray N Robertson, Rebecca Scott, Colin J Suckling, Oliver Brook Sutcliffe, Louise C Young, Simon Paul Mackay
IKKβ plays a central role in the canonical NF-kB pathway, which has been extensively characterised. The role of IKKα in the non-canonical NF-kB pathway, and indeed in the canonical pathway as a complex with IKKβ, is less well understood. One major reason for this is the absence of chemical tools designed as selective inhibitors for IKKα over IKKβ, until now. Herein, we report for the first time a series of novel, potent and selective inhibitors of IKKα. We demonstrate effective target engagement and selectivity with IKKα in U2OS cells through inhibition of IKKα-driven p100 phosphorylation in the non-canonical NF-kB pathway without affecting IKKβ-dependent IKappa-Bα loss in the canonical pathway...
July 24, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28737843/non-steroidal-anti-inflammatory-drugs-nsaids-for-cancer-related-pain-in-children-and-adolescents
#16
REVIEW
Tess E Cooper, Lauren C Heathcote, Brian Anderson, Marie-Claude Grégoire, Gustaf Ljungman, Christopher Eccleston
BACKGROUND: Pain is a common feature of childhood and adolescence around the world, and for many young people, that pain is chronic. The World Health Organization (WHO) guidelines for pharmacological treatments for persisting pain in children acknowledge that pain in children is a major public health concern of high significance in most parts of the world. Views on children's pain have changed over time and relief of pain is now seen as important. In the past, pain was largely dismissed and was frequently left untreated, and it was assumed that children quickly forgot about painful experiences...
July 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28737839/moving-an-evidence-based-parenting-program-into-the-community
#17
Caroline K P Roben, Mary Dozier, E B Caron, Kristin Bernard
Attachment and Biobehavioral Catch-up (ABC) is a parenting program developed to enhance sensitivity among parents of infants who experience early adversity. In several randomized clinical trials, the intervention's efficacy has been demonstrated. Moving interventions into the community with adequate fidelity is challenging, though, and intervention effects are often much smaller than when tested in randomized clinical trials. To enhance the likelihood that ABC is delivered with high fidelity, a microanalytic fidelity assessment was developed...
July 24, 2017: Child Development
https://www.readbyqxmd.com/read/28737834/vitamin-k-antagonists-versus-low-molecular-weight-heparin-for-the-long-term-treatment-of-symptomatic-venous-thromboembolism
#18
REVIEW
Alina Andras, Adriano Sala Tenna, Marlene Stewart
BACKGROUND: People with venous thromboembolism (VTE) generally are treated for five days with intravenous unfractionated heparin or subcutaneous low-molecular-weight heparin (LMWH), followed by three months of vitamin K antagonists (VKAs). Treatment with VKAs requires regular laboratory measurements and carries risk of bleeding; some patients have contraindications to such treatment. Treatment with LMWH has been proposed to minimise the risk of bleeding complications. This is the second update of a review first published in 2001...
July 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28737807/npy-binds-with-heme-to-form-a-npy-heme-complex-enhancing-peroxidase-activity-in-free-heme-and-promoting-npy-nitration-and-inactivation
#19
Huixian Ye, Zhen Yang, Hailing Li, Zhonghong Gao
Neuropeptide Y (NPY) is a member of the pancreatic peptide family of neuropeptides that play a crucial role in numerous central and peripheral nervous system responses. Recently, it has been shown that NPY protects cells against neurotoxic damage from β-amyloid peptides (Aβ) in Alzheimer's disease (AD). Heme is a common factor linking several metabolic perturbations in AD and altered heme metabolism has been shown to be related to the pathologies of AD. Thus, heme may have a chance to act on NPY and potentially counteract its function...
July 24, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28737760/channel-opening-and-gating-mechanism-in-ampa-subtype-glutamate-receptors
#20
Edward C Twomey, Maria V Yelshanskaya, Robert A Grassucci, Joachim Frank, Alexander I Sobolevsky
AMPA-subtype ionotropic glutamate receptors mediate fast excitatory neurotransmission throughout the central nervous system. Gated by the neurotransmitter glutamate, AMPA receptors are critical for synaptic strength and dysregulation of AMPA receptor-mediated signalling is linked to numerous neurological diseases. Here, we use cryo-electron microscopy to solve the structures of AMPA receptor-auxiliary subunit complexes in the apo, antagonist and agonist-bound states and elucidate the iris-like mechanism of ion channel opening...
July 24, 2017: Nature
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