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William A Sterling, Joseph Weiner, David Schreiber, Komal Mehta, Jeffrey P Weiss
PURPOSE: Racial differences in the incidence of prostate cancer on initial biopsy are well established, but the predictive value of African American race on the probability of prostate cancer detection on repeat biopsy is unknown. MATERIALS AND METHODS: At a single institution between January 2007 and June 2014, we reviewed 277 men who first underwent a negative transrectal ultrasound guided needle biopsy of the prostate, and who then subsequently underwent a second biopsy...
August 31, 2016: International Urology and Nephrology
Jin Ah Jung, Soo-Yun Lee, Tae-Eun Kim, Jung-Ryul Kim, Chin Kim, Wooseong Huh, Jae-Wook Ko
AIMS: Lobeglitazone has been developed for the treatment of type 2 diabetes mellitus. This study was conducted to evaluate potential drug-drug interactions between lobeglitazone and warfarin, an anticoagulant with a narrow therapeutic index. METHODS: In this open-label, three-treatment, crossover study, 24 healthy male subjects were administered lobeglitazone (0.5 mg) for 1-12 days with warfarin (25 mg) on day 5 in one period. After a washout interval, subjects were administered warfarin (25 mg) alone in the other period...
2015: Drug Design, Development and Therapy
Eitan Kerem, Michael W Konstan, Kris De Boeck, Frank J Accurso, Isabelle Sermet-Gaudelus, Michael Wilschanski, J Stuart Elborn, Paola Melotti, Inez Bronsveld, Isabelle Fajac, Anne Malfroot, Daniel B Rosenbluth, Patricia A Walker, Susanna A McColley, Christiane Knoop, Serena Quattrucci, Ernst Rietschel, Pamela L Zeitlin, Jay Barth, Gary L Elfring, Ellen M Welch, Arthur Branstrom, Robert J Spiegel, Stuart W Peltz, Temitayo Ajayi, Steven M Rowe
BACKGROUND: Ataluren was developed to restore functional protein production in genetic disorders caused by nonsense mutations, which are the cause of cystic fibrosis in 10% of patients. This trial was designed to assess the efficacy and safety of ataluren in patients with nonsense-mutation cystic fibrosis. METHODS: This randomised, double-blind, placebo-controlled, phase 3 study enrolled patients from 36 sites in 11 countries in North America and Europe. Eligible patients with nonsense-mutation cystic fibrosis (aged ≥ 6 years; abnormal nasal potential difference; sweat chloride >40 mmol/L; forced expiratory volume in 1 s [FEV1] ≥ 40% and ≤ 90%) were randomly assigned by interactive response technology to receive oral ataluren (10 mg/kg in morning, 10 mg/kg midday, and 20 mg/kg in evening) or matching placebo for 48 weeks...
July 2014: Lancet Respiratory Medicine
Di Zhou, Li-Xia Pang, Jing Guo, Ze-Ming Qi, Tao Shao, Qiu-Ping Wang, Hui-Dong Xie, Xi Yao, Clive A Randall
In the present work, the (Bi1-xCex)VO4 (x ≤ 0.6) ceramics were prepared via a solid-state reaction method and all the ceramic samples could be densified below 900 °C. From the X-ray diffraction analysis, it is found that a monoclinic scheelite solid solution can be formed in the range x ≤ 0.10. In the range 0.20 ≤ x ≤ 0.60, a composite region with both monoclinic scheelite and tetragonal zircon solid solutions was formed and the content of the zircon phase increased with the calcined or sintering temperature...
January 21, 2014: Inorganic Chemistry
T-E Kim, J-R Kim, J A Jung, M-J Kim, S-Y Lee, J-W Ko, W-T Jung, Y-W Choi, H J Lee, S-H Kim, W Huh
WHAT IS KNOWN AND OBJECTIVE: Sarpogrelate is a selective 5-hydroxytryptamine receptor subtype 2A antagonist that inhibits platelet aggregation and vasoconstriction. The aim of this study was to compare the pharmacokinetics of a sarpogrelate controlled-release formulation (CR) with those of the immediate-release formulation (IR). The effect of food on the pharmacokinetics of CR sarpogrelate was also evaluated. METHODS: A randomized, open-label, 3-period, 3-treatment crossover study was conducted in 50 healthy male subjects...
April 2014: Journal of Clinical Pharmacy and Therapeutics
Wuzhan Liu, Jianwei Fan, Yanhong Gao, Xinjian Qiu, Huifang Zhuang, Zhiquan Zhao
OBJECTIVE: To establish an HPLC method for simultaneous determination of eight iridiods in Gardeniae Fructus. METHOD: Kromasil C18 column (4. 6 mm x 250 mm, 5 microm) was adopted, with acetonitrile-water-trifluoroacetic acid (6:94: 0.05) as the mobile phase at the flow rate of 1.0 mL x min(-1). The detection wavelength was set at 238 nm, and the column temperature was 40 degrees C. RESULT: The linear ranges of geniposide, gardoside, shanzhiside, geniposidic acid, deacetyl asperulosidic acid methyl ester, gardenoside, scandoside methyl ester, and genipin gentiobioside were 1...
August 2012: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Marti Pottorff, Jeffrey D Ehlers, Christian Fatokun, Philip A Roberts, Timothy J Close
BACKGROUND: Cowpea [Vigna unguiculata (L.) Walp] exhibits a considerable variation in leaf shape. Although cowpea is mostly utilized as a dry grain and animal fodder crop, cowpea leaves are also used as a high-protein pot herb in many countries of Africa. RESULTS: Leaf morphology was studied in the cowpea RIL population, Sanzi (sub-globose leaf shape) x Vita 7 (hastate leaf shape). A QTL for leaf shape, Hls (hastate leaf shape), was identified on the Sanzi x Vita 7 genetic map spanning from 56...
2012: BMC Genomics
Swati S More, Abbas Raza, Robert Vince
Diacetyl (DA), a natural butter flavorant, is a causative agent for the lung disease obliterative bronchiolitis. Mutagenic properties of 1,2-dicarbonyls have previously been empirically linked to their possible interaction with DNA nucleobases. This study for the first time identifies chemically the adduct of DA with 2-deoxyguanosine. Selective reactivity of DA with 5'-TTTGTTTTT-3' over 5'-TTTTTTTTT-3' indicated its propensity to modify specifically the guanosine residue. Treatment of plasmid DNA, pBR322, with DA induced changes in electrophoretic mobility that are typical of ternary structure disruption...
March 28, 2012: Journal of Agricultural and Food Chemistry
Xiao-Hong Shu, Hong Li, Xiao-Xin Sun, Qian Wang, Zheng Sun, Mo-Li Wu, Xiao-Yan Chen, Chong Li, Qing-You Kong, Jia Liu
BACKGROUND: Trans-resveratrol rather than its biotransformed monosulfate metabolite exerts anti-medulloblastoma effects by suppressing STAT3 activation. Nevertheless, its effects on human glioblastoma cells are variable due to certain unknown reason(s). METHODOLOGY/PRINCIPAL FINDINGS: Citing resveratrol-sensitive UW228-3 medulloblastoma cell line and primarily cultured rat brain cells/PBCs as controls, the effect of resveratrol on LN-18 human glioblastoma cells and its relevance with metabolic pattern(s), brain-associated sulfotransferase/SULT expression and the statuses of STAT3 signaling and protein inhibitor of activated STAT3 (PIAS3) were elucidated by multiple experimental approaches...
2011: PloS One
Shinji Hidaka, Tadakazu Tokumura, Kazuo Tomono, Toyofumi Suzuki, Haruhisa Ueda, Tsuneji Nagai, Masashi Nagaoka, Rieko Nakane, Yoshiharu Machida
The formation of an inclusion complex of amoxicillin (AMX) with beta-cyclodextrin (beta-CD) in aqueous solution was confirmed by a solubility method and proton nuclear magnetic resonance (1H-NMR) spectroscopy. The apparent stability constant for the inclusion complex was 10.72 M(-1) in water at 25 degrees C. The effect of alpha-CD, beta-CD, and gamma-CD on the degradation of AMX in a pH 1.2 solution at 37 degrees C was investigated. beta-CD and gamma-CD reduced the rate of degradation. alpha-CD had no effect...
June 2010: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
Mona Darwish, Kenneth Tempero, John G Jiang, Jeffrey Thompson, Philip G Simonson
OBJECTIVE: This study was conducted to assess the dose proportionality, safety, and tolerability of fentanyl buccal tablet (FBT) in Japanese volunteers. METHODS: Healthy, opioid-naive Japanese adults received single-dose FBT 100, 200, 400, and 800 microg in a randomized, open-label, crossover fashion. Naltrexone was given to minimize the opioid effects of fentanyl. Peak serum fentanyl concentration (C(max)), time to C(max) (t(max)), area under the serum fentanyl concentration-time curve (AUC) from time 0 to infinity (AUC(0-infinity)), and AUC from 0 to the last quantifiable concentration (AUC(0-last)) were summarized using descriptive statistics...
September 2008: Archives of Drug Information
Jerzy Sikora, Jacek Magnucki, Jerzy Zietek, Lucyna Kobielska, Robert Partyka, Danuta Kokocinska, Aleksandra Białas
OBJECTIVES: The aim of the project was the assessment of clinical usefulness of the determination of blood serum homocysteine concentration, folic acid and vitamin B12 in recurrent miscarriages. METHODS: 30 non-pregnant women with recurrent miscarriages (examined group-I) and for 20 non-pregnant women without obstetric failures in medical history (control group-II) were examined. RESULTS: In the examined group (group I), the average concentration of homocysteine (9,45 micromol/l) was not statistically higher in comparison to the control group (group II) (8,47 micromol/l) (p>0,05)...
August 2007: Neuro Endocrinology Letters
Kalpana Baruah
Laboratory studies carried out using Temephos and Fenthion, two commonly used larvicides under Urban Malaria Scheme (NMEP) and NFCP for the control of mosquito larvae. The results revealed that the LC50 and LC90 values for temephos against Aedes aegypti 0.0177 and 0.0559, Anopheles stephensi 0.0148 and 0.0472, Culex quinquefasciatus 0.0157 & 0.0480 and for Culex vishnui group of mosquitoes 0.043 & 0.0118 ppm respectively. The results obtained revealed that there is a 62.8 & 94.12 times increase in the LC50 & LC90 of Cx...
June 2004: Journal of Communicable Diseases
Hirofumi Uehara, Masaki Miyamoto, Kentaro Kato, Yasushi Cho, Takanori Kurokawa, Soichi Murakami, Akira Fukunaga, Yuma Ebihara, Hiroyuki Kaneko, Hiroyuki Hashimoto, Yosihiro Murakami, Toshiaki Shichinohe, You Kawarada, Tomoo Itoh, Shunichi Okushiba, Satoshi Kondo, Hiroyuki Katoh
BACKGROUND: The human Mut-L-Homologon-1 (MLH1) and Mut-S-Homologon-2 (MSH2) are post replication mismatch repair (MMR) genes. METHODS: We examined the correlation of the clinical features of 122 patients with esophageal squamous cell carcinoma (ESCC) with the expression of MLH1 and MSH2 by immunohistochemical analysis. RESULTS: According to our criteria, 34 and 25 cases did not express MLH1 and MSH2, respectively. Expression of both the MLH1 and MSH2 gene products was observed in 73 (59...
November 1, 2005: Journal of Surgical Oncology
D Acosta, T Affolder, T Akimoto, M G Albrow, D Ambrose, S Amerio, D Amidei, A Anastassov, K Anikeev, A Annovi, J Antos, M Aoki, G Apollinari, T Arisawa, J-F Arguin, A Artikov, W Ashmanskas, A Attal, F Azfar, P Azzi-Bacchetta, N Bacchetta, H Bachacou, W Badgett, A Barbaro-Galtieri, G J Barker, V E Barnes, B A Barnett, S Baroiant, M Barone, G Bauer, F Bedeschi, S Behari, S Belforte, G Bellettini, J Bellinger, D Benjamin, A Beretvas, A Bhatti, M Binkley, D Bisello, M Bishai, R E Blair, C Blocker, K Bloom, B Blumenfeld, A Bocci, A Bodek, G Bolla, A Bolshov, P S L Booth, D Bortoletto, J Boudreau, S Bourov, C Bromberg, E Brubaker, J Budagov, H S Budd, K Burkett, G Busetto, P Bussey, K L Byrum, S Cabrera, P Calafiura, M Campanelli, M Campbell, A Canepa, M Casarsa, D Carlsmith, S Carron, R Carosi, M Cavalli-Sforza, A Castro, P Catastini, D Cauz, A Cerri, C Cerri, L Cerrito, J Chapman, C Chen, Y C Chen, M Chertok, G Chiarelli, G Chlachidze, F Chlebana, I Cho, K Cho, D Chokheli, M L Chu, S Chuang, J Y Chung, W-H Chung, Y S Chung, C I Ciobanu, M A Ciocci, A G Clark, D Clark, M Coca, A Connolly, M Convery, J Conway, B Cooper, M Cordelli, G Cortiana, J Cranshaw, J Cuevas, R Culbertson, C Currat, D Cyr, D Dagenhart, S Da Ronco, S D'Auria, P de Barbaro, S De Cecco, G De Lentdecker, S Dell'agnello, M Dell'orso, S Demers, L Demortier, M Deninno, D De Pedis, P F Derwent, C Dionisi, J R Dittmann, P Doksus, A Dominguez, S Donati, M Donega, J Donini, M D'Onofrio, T Dorigo, V Drollinger, K Ebina, N Eddy, R Ely, R Erbacher, M Erdmann, D Errede, S Errede, R Eusebi, H-C Fang, S Farrington, I Fedorko, R G Feild, M Feindt, J P Fernandez, C Ferretti, R D Field, I Fiori, G Flanagan, B Flaugher, L R Flores-Castillo, A Foland, S Forrester, G W Foster, M Franklin, J Freeman, H Frisch, Y Fujii, I Furic, A Gajjar, A Gallas, J Galyardt, M Gallinaro, M Garcia-Sciveres, A F Garfinkel, C Gay, H Gerberich, D W Gerdes, E Gerchtein, S Giagu, P Giannetti, A Gibson, K Gibson, C Ginsburg, K Giolo, M Giordani, G Giurgiu, V Glagolev, D Glenzinski, M Gold, N Goldschmidt, D Goldstein, J Goldstein, G Gomez, G Gomez-Ceballos, M Goncharov, O González, I Gorelov, A T Goshaw, Y Gotra, K Goulianos, A Gresele, M Griffiths, C Grosso-Pilcher, M Guenther, J Guimaraes da Costa, C Haber, K Hahn, S R Hahn, E Halkiadakis, R Handler, F Happacher, K Hara, M Hare, R F Harr, R M Harris, F Hartmann, K Hatakeyama, J Hauser, C Hays, H Hayward, E Heider, B Heinemann, J Heinrich, M Hennecke, M Herndon, C Hill, D Hirschbuehl, A Hocker, K D Hoffman, A Holloway, S Hou, M A Houlden, B T Huffman, Y Huang, R E Hughes, J Huston, K Ikado, J Incandela, G Introzzi, M Iori, Y Ishizawa, C Issever, A Ivanov, Y Iwata, B Iyutin, E James, D Jang, J Jarrell, D Jeans, H Jensen, E J Jeon, M Jones, K K Joo, S Jun, T Junk, T Kamon, J Kang, M Karagoz Unel, P E Karchin, S Kartal, Y Kato, Y Kemp, R Kephart, U Kerzel, V Khotilovich, B Kilminster, D H Kim, H S Kim, J E Kim, M J Kim, M S Kim, S B Kim, S H Kim, T H Kim, Y K Kim, B T King, M Kirby, L Kirsch, S Klimenko, B Knuteson, B R Ko, H Kobayashi, P Koehn, D J Kong, K Kondo, J Konigsberg, K Kordas, A Korn, A Korytov, K Kotelnikov, A V Kotwal, A Kovalev, J Kraus, I Kravchenko, A Kreymer, J Kroll, M Kruse, V Krutelyov, S E Kuhlmann, N Kuznetsova, A T Laasanen, S Lai, S Lami, S Lammel, J Lancaster, M Lancaster, R Lander, K Lannon, A Lath, G Latino, R Lauhakangas, I Lazzizzera, Y Le, C Lecci, T Lecompte, J Lee, J Lee, S W Lee, N Leonardo, S Leone, J D Lewis, K Li, C Lin, C S Lin, M Lindgren, T M Liss, D O Litvintsev, T Liu, Y Liu, N S Lockyer, A Loginov, M Loreti, P Loverre, R-S Lu, D Lucchesi, P Lujan, P Lukens, L Lyons, J Lys, R Lysak, D Macqueen, R Madrak, K Maeshima, P Maksimovic, L Malferrari, G Manca, R Marginean, M Martin, A Martin, V Martin, M Martínez, T Maruyama, H Matsunaga, M Mattson, P Mazzanti, K S McFarland, D McGivern, P M McIntyre, P McNamara, R Ncnulty, S Menzemer, A Menzione, P Merkel, C Mesropian, A Messina, T Miao, N Miladinovic, L Miller, R Miller, J S Miller, R Miquel, S Miscetti, G Mitselmakher, A Miyamoto, Y Miyazaki, N Moggi, B Mohr, R Moore, M Morello, A Mukherjee, M Mulhearn, T Muller, R Mumford, A Munar, P Murat, J Nachtman, S Nahn, I Nakamura, I Nakano, A Napier, R Napora, D Naumov, V Necula, F Niell, J Nielsen, C Nelson, T Nelson, C Neu, M S Neubauer, C Newman-Holmes, A-S Nicollerat, T Nigmanov, L Nodulman, O Norniella, K Oesterberg, T Ogawa, S H Oh, Y D Oh, T Ohsugi, T Okusawa, R Oldeman, R Orava, W Orejudos, C Pagliarone, F Palmonari, R Paoletti, V Papadimitriou, S Pashapour, J Patrick, G Pauletta, M Paulini, T Pauly, C Paus, D Pellett, A Penzo, T J Phillips, G Piacentino, J Piedra, K T Pitts, C Plager, A Pompos, L Pondrom, G Pope, O Poukhov, F Prakoshyn, T Pratt, A Pronko, J Proudfoot, F Ptohos, G Punzi, J Rademacker, A Rakitine, S Rappoccio, F Ratnikov, H Ray, A Reichold, B Reisert, V Rekovic, P Renton, M Rescigno, F Rimondi, K Rinnert, L Ristori, W J Robertson, A Robson, T Rodrigo, S Rolli, L Rosenson, R Roser, R Rossin, C Rott, J Russ, A Ruiz, D Ryan, H Saarikko, A Safonov, R St Denis, W K Sakumoto, G Salamanna, D Saltzberg, C Sanchez, A Sansoni, L Santi, S Sarkar, K Sato, P Savard, A Savoy-Navarro, P Schemitz, P Schlabach, E E Schmidt, M P Schmidt, M Schmitt, L Scodellaro, A Scribano, F Scuri, A Sedov, S Seidel, Y Seiya, F Semeria, L Sexton-Kennedy, I Sfiligoi, M D Shapiro, T Shears, P F Shepard, M Shimojima, M Shochet, Y Shon, I Shreyber, A Sidoti, J Siegrist, M Siket, A Sill, P Sinervo, A Sisakyan, A Skiba, A J Slaughter, K Sliwa, D Smirnov, J R Smith, F D Snider, R Snihur, S V Somalwar, J Spalding, M Spezziga, L Spiegel, F Spinella, M Spiropulu, P Squillacioti, H Stadie, A Stefanini, B Stelzer, O Stelzer-Chilton, J Strologas, D Stuart, A Sukhanov, K Sumorok, H Sun, T Suzuki, A Taffard, R Tafirout, S F Takach, H Takano, R Takashima, Y Takeuchi, K Takikawa, M Tanaka, R Tanaka, N Tanimoto, S Tapprogge, M Tecchio, P K Teng, K Terashi, R J Tesarek, S Tether, J Thom, A S Thompson, E Thomson, P Tipton, V Tiwari, S Tkaczyk, D Toback, K Tollefson, T Tomura, D Tonelli, M Tönnesmann, S Torre, D Torretta, W Trischuk, J Tseng, R Tsuchiya, S Tsuno, D Tsybychev, N Turini, M Turner, F Ukegawa, T Unverhau, S Uozumi, D Usynin, L Vacavant, A Vaiciulis, A Varganov, E Vataga, S Vejcik, G Velev, G Veramendi, T Vickey, R Vidal, I Vila, R Vilar, I Volobouev, M von der Mey, P Wagner, R G Wagner, R L Wagner, W Wagner, R Wallny, T Walter, T Yamashita, K Yamamoto, Z Wan, M J Wang, S M Wang, A Warburton, B Ward, S Waschke, D Waters, T Watts, M Weber, W C Wester, B Whitehouse, A B Wicklund, E Wicklund, H H Williams, P Wilson, B L Winer, P Wittich, S Wolbers, M Wolter, M Worcester, S Worm, T Wright, X Wu, F Würthwein, A Wyatt, A Yagil, U K Yang, W Yao, G P Yeh, K Yi, J Yoh, P Yoon, K Yorita, T Yoshida, I Yu, S Yu, Z Yu, J C Yun, L Zanello, A Zanetti, I Zaw, F Zetti, J Zhou, A Zsenei, S Zucchelli et al.
We present a measurement of relative partial widths and decay rate CP asymmetries in K-K+ and pi(-)pi(+) decays of D0 mesons produced in pp collisions at sqrt[s]=1.96 TeV. We use a sample of 2x10(5) D(*+)-->D0pi(+) (and charge conjugate) decays with the D0 decaying to K-pi(+), K-K+, and pi(-)pi(+), corresponding to 123 pb(-1) of data collected by the Collider Detector at Fermilab II experiment at the Fermilab Tevatron collider. No significant direct CP violation is observed. We measure Gamma(D0-->K-K+)/Gamma(D0-->K-pi(+))=0...
April 1, 2005: Physical Review Letters
Matteo Bonetti, Alessandro Fontana, Biagio Cotticelli, Giorgio Dalla Volta, Massimiliano Guindani, Marco Leonardi
BACKGROUND AND PURPOSE: Reports about steroids and oxygen-ozone therapy to treat lower back pain have been increasing. The purpose of our study was to compare the clinical outcomes in patients treated with infiltrations of O(2)-O(3) gas or steroids at short-, medium-, and long-term follow-up. METHODS: A total of 306 patients (166 with primarily disk disease, 140 with nondisk vertebral disease) with acute or chronic low back and sciatic nerve pain received a CT-guided intraforaminal infiltration of an O(2)-O(3) gas mixture or an periradicular infiltration of steroids...
May 2005: AJNR. American Journal of Neuroradiology
Pamela U Freda, Laurence Katznelson, Aart Jan van der Lely, Carlos M Reyes, Shouhao Zhao, Daniel Rabinowitz
CONTEXT: Although considerable data exist on the use of long-acting somatostatin analogs to treat acromegaly, their reported efficacy differs substantially among trials. OBJECTIVE: We conducted a meta-analysis to derive definitive estimates of their efficacy for biochemical control and tumor shrinkage. DATA SOURCES: A search of literature was conducted through 2003, primarily via PubMed. STUDY SELECTION: Inclusion criteria, met in 44 trials, included at least 3 months of secondary octreotide long-acting release (LAR) or lanreotide slow release (SR) therapy or of primary octreotide LAR, lanreotide SR, or sc octreotide therapy and clearly reported data on biochemical efficacy and/or tumor shrinkage...
August 2005: Journal of Clinical Endocrinology and Metabolism
B Srp, P Velebil
OBJECTIVE: Analysis of maternal mortality in the Czech Republic in 2001. DESIGN: Retrospective statistical and clinical analysis. SETTING: Mother and Child Care Institute, Prague-Podoli. METHODS: We used database of 9 cases of maternal deaths in the Czech Republic during 2001 to analyze their causes, clinical courses especially related to obstetrical surgery, adequacy of provided care, and characteristics of their occurrence...
January 2005: Ceská Gynekologie
Ahmed El-Feel, John W Davis, Serdar Deger, Jan Roigas, Andreas H Wille, Dietmar Schnorr, Amr Abdel Hakiem, Stefan Loening, Ingolf A Tuerk
OBJECTIVE: Laparoscopic radical prostatectomy (LRP) has been refined by experienced surgeons into a competitive treatment alternative for localized prostate cancer. Less is known, however, about the outcomes of "learning curve" cases from newly trained surgeons. We prospectively studied 100 cases of LRP performed by 2 senior and 2 junior surgeons and addressed the rates of positive margins-an important early endpoint of oncologic efficacy. METHODS: 100 consecutive cases of LRP were performed by two senior (n=62) and two junior surgeons (n=38) by a 5-port transperitoneal route...
June 2003: European Urology
H G Scheil, S Schuhen, W Huckenbeck, H D Schmidt
The phenotype and allele frequencies of alpha-1-antitrypsin has been studied by an IEF technique (pH 4.2-4.9) in ten population samples from the Balkans. The allele frequencies varied from 0.6667 to 0.7361 (*M1), 0.1100 to 0.1793 (*M2), 0.0992 to 0.1700 (*M3), 0 to 0.0105 (*S), 0 to 0.0078 (*Z) and 0 to 0.0172 (others). The results were compared with data from South and Middle European populations from the literature. Most of the populations form a cluster with small genetic distances, and a weak relationship to geographical distributions...
December 2002: Collegium Antropologicum
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