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https://www.readbyqxmd.com/read/27540228/medication-review-of-children-on-long-term-medications-a-review-of-the-literature
#1
Jeff Aston, Chi Huynh, Anthony Sinclair, Keith Wilson, David Terry
INTRODUCTION: Children on long term medication may be under the care of more than one medical team including the patients GP. Children on chronic medication should be supported and their medications reviewed, especially in cases of polypharmacy. Medicines Use Reviews (MURs) were introduced into the pharmacy contract in 2005. The service was designed for community pharmacists to review patients on long term medication. The service specified that MURs were done on patients who can give consent and cannot be conducted with a parent or carer...
September 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27297624/news-from-tartary-an-ethnopharmacological-approach-to-drug-and-therapeutic-discovery
#2
Nicholas Moore, Nawel Hamza, Benedicte Berke, Anwar Umar
Ethnopharmacology aims to identify new therapeutic agents based on their traditional use. It begins by the identification of disease states, and of the traditional therapies for these, most commonly herbals. Herbals of interest are selected from ethnopharmacological surveys, and tested on experimental models of the diseases of interest. Once the activity of the traditional remedy is demonstrated, including dose-dependence, if possible comparatively to reference medications, the active ingredients can be explored, if possible using bioguided extraction...
June 13, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/26620290/criminal-activity-or-treatable-health-condition-news-media-framing-of-opioid-analgesic-abuse-in-the-united-states-1998-2012
#3
Emma E McGinty, Alene Kennedy-Hendricks, Julia Baller, Jeff Niederdeppe, Sarah Gollust, Colleen L Barry
OBJECTIVE: Opioid analgesic abuse is a complex and relatively new public health problem, and to date little is known about how the news media frame the issue. METHODS: To better understand how this issue has been framed in public discourse, an analysis was conducted of the volume and content of news media coverage of opioid analgesic abuse over a 15-year period from 1998 to 2012 (N=673 news stories). A 70-item structured coding instrument was used to measure items in four domains that prior research suggests can influence public attitudes about health and social issues: causes, solutions, and consequences of the problem and individual depictions of persons who abuse opioid analgesics...
April 1, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/26297571/expedited-programs-for-serious-conditions-an-update-on-breakthrough-therapy-designation
#4
REVIEW
Martin Kwok, Theresa Foster, Michael Steinberg
PURPOSE: Our aim was to describe the regulatory pathways made available by the US Food and Drug Administration (FDA) to expedite the drug development and approval process, with a focus on the benefits and limitations of the Breakthrough Therapy Designation (BTD) pathway. METHODS: Published materials consisting of journal articles, press releases, government documents, and news articles from pharmaceutical publishers were identified through online databases (ie, Medline and Scopus), the FDA website, and Internet search engines (eg, Google)...
September 2015: Clinical Therapeutics
https://www.readbyqxmd.com/read/25869219/vermont-responds-to-its-opioid-crisis
#5
Thomas A Simpatico
Vermont is one of the more forward-thinking states in the nation with a history of taking groundbreaking approaches to complex social issues. In his Jan 8, 2014 State of the State Address, Vermont Governor Peter Shumlin announced that Vermont was in the midst of an opioid addiction epidemic. Though Vermont had called attention to its opioid crisis, it soon became clear that many other states shared this problem. Economic modeling of expanded access to maintenance therapy with either methadone or buprenorphine is felt to have "high value" because the added health care costs of treatment are offset by reductions in other health care costs that occur when individuals with opioid dependence begin treatment...
November 2015: Preventive Medicine
https://www.readbyqxmd.com/read/25850880/finding-truth-in-a-world-full-of-spin-myth-busting-in-the-case-of-sovaldi
#6
REVIEW
Leora Schiff
PURPOSE: Public discourse regarding the hepatitis C virus (HCV) drug Sovaldi® (sofosbuvir) has become inflamed, generating much heat but little light concerning the clinical, health economic, and quality-of-life merits of Sovaldi®. The purpose of this article is to provide a factual basis for evaluating the claims regarding the benefits of Sovaldi® relative to its costs. METHODS: A comprehensive review was conducted of news stories highlighted in the daily updates of the electronic newsletters BIO SmartBrief, FiercePharma, FierceBiotech and BioCentury Extra published from November 1, 2013, through December 31, 2014, on the topics of the HCV market, Sovaldi®, and other HCV therapeutics...
May 1, 2015: Clinical Therapeutics
https://www.readbyqxmd.com/read/25801940/development-of-novel-pharmaceutical-agents-for-alzheimer-s-disease-the-impact-of-regulatory-initiatives-in-japan-and-the-united-states
#7
Katsura Tsukamoto
PURPOSE: The incidence of Alzheimer's disease (AD) has been steadily increasing worldwide. AD is a serious disease that has both societal and economic impacts. The greatest risk factor for AD is aging. Thus, because of the rapidly aging population in Japan, the development of new, effective drugs for AD is urgently needed. The goal of the present article was to analyze the status, clarify the problems, and discuss the scientific and political challenges of disease-modifying drug development for AD...
August 2015: Clinical Therapeutics
https://www.readbyqxmd.com/read/25658389/hepatitis-c-therapy-looking-toward-interferon-sparing-regimens
#8
REVIEW
Trang H Au, Christopher J Destache, Renuga Vivekanandan
OBJECTIVE: To describe chronic hepatitis C virus (HCV) infection, including its epidemiology and pathophysiology; review current treatment options for HCV infection; recognize investigational agents being studied as part of interferon-free therapy; and summarize clinical trials for the new agents. DATA SOURCES: PubMed for 2004 through August 2014 using search terms hepatitis C, American Association for the Study of Liver Diseases, sofosbuvir, simeprevir, and as needed specific names of other agents in development during this time; news articles and news releases about company actions with regard to clinical trials and filings for marketing approval in the United States...
March 2015: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/25050053/new-drugs-drug-news-new-medical-devices
#9
(no author information available yet)
FDA approvals, drug indications, and updates.
June 2014: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/24796314/a-guide-to-reading-health-care-news-stories
#10
Gary Schwitzer
From April 16, 2006, through May 30, 2013, a team of reviewers from HealthNewsReview.org, many of whom were physicians, evaluated the reporting by US news organizations on new medical treatments, tests, products, and procedures. After reviewing 1889 stories (approximately 43% newspaper articles, 30% wire or news services stories, 15% online pieces [including those by broadcast and magazine companies], and 12% network television stories), the reviewers graded most stories unsatisfactory on 5 of 10 review criteria: costs, benefits, harms, quality of the evidence, and comparison of the new approach with alternatives...
July 2014: JAMA Internal Medicine
https://www.readbyqxmd.com/read/24579297/physicians-pharmacists-and-the-importance-of-quality-pharmacy-compounding
#11
Loyd V Allen
The adverse events associated with the New England Compounding Center are rare. Nonetheless, when they do occur, such events tend to gain a lot of press coverage, and the news stories are repeated over and over for months, resulting in an unfavorable impression of the profession of pharmaceutical compounding. It is evident and appropriate that pharmacy practice, including compounding pharmacy, is well-regulated and monitored. The fact is that compounded medications are a necessity for reasons such as commercial products not being patient-specific, the unavailability of limited dosage forms and strengths from manufacturers, drug shortages, and the unavailability of manufactured drugs for pediatrics, along with many other reasons outlined within this article...
November 2013: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/24340668/-topics-from-overseas-drug-safety-information-in-the-past-five-years
#12
Kimiko Amanuma
The Drug Safety Information Section of the Division of Safety Information on Drug, Food and Chemicals has been providing bulletins titled "Overseas Drug Safety Information" in Japanese since 2003. These bulletins comprise summarized and translated reports of important post-marketing drug safety information that are published by foreign regulatory agencies such as the US Food and Drug Administration (FDA) and the European Medical Agency. A new issue of the bulletin is posted every two weeks on the website of the National Institute of Health Sciences, Japan; to date (May 2013), a total of 280 issues have been posted, covering approximately 2400 foreign news items and articles since its inception...
2013: Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo Hōkoku, Bulletin of National Institute of Health Sciences
https://www.readbyqxmd.com/read/23842213/the-nocebo-effect-patient-expectations-and-medication-side-effects
#13
REVIEW
Kate Faasse, Keith J Petrie
Expectation of treatment side effects is consistently linked with those symptoms being realised. Patient expectations, including those generated by the informed consent process, can have a large influence on the side effects that patients feel after starting a new medical treatment. Such symptoms may be the result of the nocebo effect, whereby the expectation of side effects leads to them being experienced. Side effects may also be due to the misattribution of pre-existing or unrelated symptoms to the new medication...
September 2013: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/23696308/publication-bias-with-a-focus-on-psychiatry-causes-and-solutions
#14
REVIEW
Erick H Turner
Publication bias undermines the integrity of the evidence base by inflating apparent drug efficacy and minimizing drug harms, thus skewing the risk-benefit ratio. This paper reviews the topic of publication bias with a focus on drugs prescribed for psychiatric conditions, especially depression, schizophrenia, bipolar disorder, and autism. Publication bias is pervasive; although psychiatry/psychology may be the most seriously afflicted field, it occurs throughout medicine and science. Responsibility lies with various parties (authors as well as journals, academia as well as industry), so the motives appear to extend beyond the financial interests of drug companies...
June 2013: CNS Drugs
https://www.readbyqxmd.com/read/23647293/from-trial-highlights-to-clinical-context-putting-american-society-of-clinical-oncology-gastrointestinal-news-into-practice
#15
Giuseppe Aprile, Stefania Eufemia Lutrino, Alberto Sobrero
Celebrating its tenth anniversary, the Gastrointestinal Cancers Symposium is a world class, international conference focused on research and multidisciplinary management of digestive tract malignancies, co-sponsored by the American Society of Clinical Oncology, the American Society for Radiation Oncology, the American Gastroenterological Association Institute and the Society of Surgical Oncology. This premium meeting was held from 24 to 26 January 2013 in San Francisco (CA, USA) and, in line with its principal mission, it sought to globally embrace prevention, screening, diagnostics, translational research and multimodal treatment, moving on three major anatomic tracks (upper gastrointestinal cancers, pancreatic/hepatobiliary tumors and colorectal malignancies)...
May 2013: Future Oncology
https://www.readbyqxmd.com/read/23641131/new-drugs-drug-news-new-medical-devices
#16
(no author information available yet)
FDA approvals, drug indications, and updates.
March 2013: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/23599673/new-drugs-drug-news-new-medical-devices
#17
(no author information available yet)
FDA approvals, drug indications, and updates.
February 2013: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/23409656/-pulmonary-medicine-2012-news-for-the-general-practitioner
#18
REVIEW
G Gex, N Petitpierre, F Charbonnier, T Rochat
This review reports on papers published in 2012 that will most likely impact on daily medical practice in four different areas of pulmonary medicine. How should treatment of asthma with inhaled corticosteroids be adjusted on the long run? Should idiopathic pulmonary fibrosis receive treatment with immunosuppressive drugs? Is a long-term treatment with azithromycine for bronchiectasis supported by evidence, apart from patients with cystic fibrosis? And finally, can treatment of obstructive sleep apnea with continuous positive pressure (CPAP) prevent the occurrence of new, systemic hypertension?...
January 16, 2013: Revue Médicale Suisse
https://www.readbyqxmd.com/read/23367707/-2012-news-in-neurology
#19
REVIEW
V Alvarez, A O Rossetti, P Michel, T Kuntzer, B Nater, J-F Démonet, M Schluep, R Du Pasquier, F Vingerhoets
In 2012, intramuscular midazolam appears as effective as intravenous lorezepam for the first line treatment of convulsive status epilepticus. Perampanel, a new anti-epileptic drug, will be soon available. Two oral treatments are now available for stroke prevention in atrial fibrillation setting. The methylphenidate and the Tai Chi could increase the walk capacity of patients suffering from Parkinson disease. A comprehensive cardiac work-up is essential for some congenital myopathy. A new drug against migraine seems free from vasoconstrictive effect...
January 9, 2013: Revue Médicale Suisse
https://www.readbyqxmd.com/read/23319843/new-drugs-drug-news-new-medical-devices
#20
(no author information available yet)
FDA approvals, drug indications, and updates.
December 2012: P & T: a Peer-reviewed Journal for Formulary Management
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