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Bronchiectasis and Chronic obstructive pulmonary disease

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https://www.readbyqxmd.com/read/27867566/effectiveness-of-temporary-positive-expiratory-pressure-t-pep-at-home-and-at-hospital-in-patients-with-severe-chronic-obstructive-pulmonary-disease
#1
Valentina Mascardi, Bruna Grecchi, Cornelius Barlascini, Paolo Banfi, Antonello Nicolini
BACKGROUND: Temporary positive airway pressure (T-PEP) is a tool recently introduced in the treatment of chronic obstructive pulmonary disease (COPD) or bronchiectasis. It demonstrated encouraging results also in severe COPD patients. The aim of this study is verify if adding T-PEP to best bronchodilator therapy both in clinic and home administering could reduce disease exacerbations and improve lung function in patients with severe COPD. METHODS: A total of 142 patients with severe COPD (FEV1 <50%) were enrolled; 120 were randomized in three groups: a group treated with T-PEP at home, a group with T-PEP at hospital and a group with medical therapy only (control group)...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27861566/findings-on-thoracic-computed-tomography-scans-and-respiratory-outcomes-in-persons-with-and-without-chronic-obstructive-pulmonary-disease-a-population-based-cohort-study
#2
Wan C Tan, Cameron J Hague, Jonathon Leipsic, Jean Bourbeau, Liyun Zheng, Pei Z Li, Don D Sin, Harvey O Coxson, Miranda Kirby, James C Hogg, Rekha Raju, Jeremy Road, Denis E O'Donnell, Francois Maltais, Paul Hernandez, Robert Cowie, Kenneth R Chapman, Darcy D Marciniuk, J Mark FitzGerald, Shawn D Aaron
BACKGROUND: Thoracic computed tomography (CT) scans are widely performed in clinical practice, often leading to detection of airway or parenchymal abnormalities in asymptomatic or minimally symptomatic individuals. However, clinical relevance of CT abnormalities is uncertain in the general population. METHODS: We evaluated data from 1361 participants aged ≥40 years from a Canadian prospective cohort comprising 408 healthy never-smokers, 502 healthy ever-smokers, and 451 individuals with spirometric evidence of chronic obstructive pulmonary disease (COPD) who had thoracic CT scans...
2016: PloS One
https://www.readbyqxmd.com/read/27804985/a-murine-model-of-early-pseudomonas-aeruginosa-lung-disease-with-transition-to-chronic-infection
#3
H K Bayes, N Ritchie, S Irvine, T J Evans
Pseudomonas aeruginosa (PA) remains an important pathogen in patients with cystic fibrosis (CF) lung disease as well as non-CF bronchiectasis and chronic obstructive airways disease. Initial infections are cleared but chronic infection with mucoid strains ensues in the majority of CF patients and specific interventions to prevent this critical infection transition are lacking. The PA bead model has been widely used to study pulmonary P.aeruginosa infection but has limitations in animal husbandry and in accurately mimicking human disease...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27794529/bronchiectasis-and-aspergillus-how-are-they-linked
#4
Anthony De Soyza, Stefano Aliberti
Bronchiectasis is a chronic airway infection syndrome, distinct from cystic fibrosis that is rising in prevalence and is associated with significant morbidity and mortality. It can be caused by many etiologies including post-infectious effects or be seen in common lung diseases such as chronic obstructive pulmonary disease (COPD) or severe asthma. Bronchiectasis is associated with many Aspergillus-associated syndromes: allergic bronchopulmonary aspergillosis (ABPA) may complicate asthma, thus leading to bronchiectasis as part of the diagnostic criteria of ABPA or can complicate preexisting bronchiectasis due to another etiology...
October 28, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27793116/the-incidence-presentation-outcomes-risk-of-mortality-and-economic-data-of-drug-induced-liver-injury-from-a-national-database-in-thailand-a-population-base-study
#5
Abhasnee Sobhonslidsuk, Kittiyod Poovorawan, Ngamphol Soonthornworasiri, Wirichada Pan-Ngum, Kamthorn Phaosawasdi
BACKGROUND: Toxic liver diseases are mainly caused by drug-induced liver injury (DILI). We assessed incidences and outcomes of DILI including associated factors for mortality. METHODS: We performed a population-based study of hospitalized patients with DILI. Information was retrieved from the Nationwide Hospital Admission Data using ICD-10 code of toxic liver diseases (K71) and additional codes (T36-T65). The associated factors were analyzed with log-rank test, univariate and multiple cox regression analysis...
October 28, 2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27730203/the-best-of-respiratory-infections-from-the-2015-european-respiratory-society-international-congress
#6
Eva Polverino, Graham H Bothamley, Delia Goletti, Jan Heyckendorf, Giovanni Sotgiu, Stefano Aliberti
The breadth and quality of scientific presentations on clinical and translational research into respiratory infections at the 2015 European Respiratory Society (ERS) International Congress in Amsterdam, the Netherlands, establishes this area as one of the leadings fields in pulmonology. The host-pathogen relationship in chronic obstructive pulmonary disease, and the impact of comorbidities and chronic treatment on clinical outcomes in patients with pneumonia were studied. Various communications were dedicated to bronchiectasis and, in particular, to different prognostic and clinical aspects of this disease, including chronic infection with Pseudomonas and inhaled antibiotic therapy...
July 2016: ERJ Open Research
https://www.readbyqxmd.com/read/27627973/smoking-status-and-a-pulmonary-function-test-in-patients-with-rotator-cuff-tears
#7
Chiharu Yoshii, Soushi Uchida, Shingo Noguchi, Ryo Torii, Ikuko Shimabukuro, Kazuhiro Yatera
Although chronic obstructive pulmonary disease (COPD) affects one in several smokers, only a few patients are correctly diagnosed compared to the estimated number of patients. Several recent reports indicate that the development of rotator cuff tears is related to smoking. In this study, we investigated smoking status in patients with rotator cuff tears and evaluated the possibility of undiagnosed COPD by a pulmonary function test. The subjects were 150 consecutive patients over 40 years old, who had been diagnosed with rotator cuff tears and had been examined by a pulmonary function test before surgery in our orthopedic department between April 2011 and June 2015...
September 2016: Journal of UOEH
https://www.readbyqxmd.com/read/27592691/minimal-clinically-important-difference-for-change-in-6-minute-walk-test-distance-of-adults-with-pathology-a-systematic-review
#8
Richard W Bohannon, Rebecca Crouch
RATIONALE, AIMS, AND OBJECTIVES: The 6-minute walk test (6MWT) is widely used as a test of functional exercise capacity. Several studies have reported the minimal clinically important difference (MCID) for the 6MWT; however, the findings of the studies have not been examined in the context of one another. In this review, we aimed to summarize available information on the MCID for the 6MWT performed by patients with pathology. METHODS: Relevant literature was identified by searches of 3 electronic databases (PubMed, Scopus, and Cumulative Index of Nursing and Allied Health), examination of article reference lists, and consultation with an expert...
September 4, 2016: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/27569224/bronchiectasis-as-a-comorbidity-of-chronic-obstructive-pulmonary-disease-implications-and-future-research
#9
EDITORIAL
Ya-Hong Chen, Yong-Chang Sun
No abstract text is available yet for this article.
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27564672/delivery-of-alpha-1-antitrypsin-to-airways
#10
Matthias Griese, Gerhard Scheuch
Treatment with exogenous alpha-1 antitrypsin (AAT), a potent serine protease inhibitor, was developed originally for chronic obstructive pulmonary disease associated with AAT deficiency; however, other lung conditions involving neutrophilic inflammation and proteolytic tissue injury related to neutrophil elastase and other serine proteases may also be considered for AAT therapy. These conditions include bronchiectasis caused by primary ciliary dyskinesia, cystic fibrosis, and other diseases associated with an increased free elastase activity in the airways...
August 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27492531/the-effect-of-n-acetylcysteine-on-biofilms-implications-for-the-treatment-of-respiratory-tract-infections
#11
REVIEW
Francesco Blasi, Clive Page, Gian Maria Rossolini, Lucia Pallecchi, Maria Gabriella Matera, Paola Rogliani, Mario Cazzola
OBJECTIVES: In airway infections, biofilm formation has been demonstrated to be responsible for both acute and chronic events, and constitutes a genuine challenge in clinical practice. Difficulty in eradicating biofilms with systemic antibiotics has led clinicians to consider the possible role of non-antibiotic therapy. The aim of this review is to examine current evidence for the use of N-acetylcysteine (NAC) in the treatment of biofilm-related respiratory infections. METHODS: Electronic searches of PUBMED up to September 2015 were conducted, searching for 'biofilm', 'respiratory tract infection', 'N-acetylcysteine', 'cystic fibrosis', 'COPD', 'bronchiectasis', 'otitis', and 'bronchitis' in titles and abstracts...
August 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27448179/ciprofloxacin-dry-powder-for-inhalation-in-patients-with-noncystic-fibrosis-bronchiectasis-or-chronic-obstructive-pulmonary-disease-and-in-healthy-volunteers
#12
Heino Stass, Johannes Nagelschmitz, Dominik Kappeler, Knut Sommerer, Claudius Kietzig, Boris Weimann
BACKGROUND: Ciprofloxacin dry powder for inhalation (Ciprofloxacin DPI) is in development as long-term intermittent therapy to reduce the frequency of acute exacerbations in noncystic fibrosis bronchiectasis (NCFB) patients with respiratory bacterial pathogens. There is no approved therapy in this indication. Reliable, reproducible lung deposition is a prerequisite for inhaled drugs. METHODS: In this phase I study, six patients with NCFB, six with chronic obstructive pulmonary disease (COPD), and 12 healthy volunteers (HVs), received one dose of (99m)Tc-Ciprofloxacin DPI 32...
July 22, 2016: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/27442650/pneumothorax-associated-with-nontuberculous-mycobacteria-a-retrospective-study-of-69-patients
#13
Masako Ueyama, Takanori Asakura, Kozo Morimoto, Ho Namkoong, Shuichi Matsuda, Takeshi Osawa, Makoto Ishii, Naoki Hasegawa, Atsuyuki Kurashima, Hajime Goto
The incidence of nontuberculous mycobacterial pulmonary disease (NTMPD) is increasing worldwide. Secondary spontaneous pneumothorax occurs as a complication of underlying lung disease and is associated with higher morbidity, mortality, and recurrence than primary spontaneous pneumothorax. We here investigated the clinical features and long-term outcomes of pneumothorax associated with NTMPD.We conducted a retrospective study on consecutive adult patients with pneumothorax associated with NTMPD at Fukujuji Hospital and Keio University Hospital from January 1992 to December 2013...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27442646/factors-associated-with-bronchiectasis-in-patients-with-moderate-severe-chronic-obstructive-pulmonary-disease
#14
Jianmin Jin, Wenling Yu, Shuling Li, Lijin Lu, Xiaofang Liu, Yongchang Sun
A high prevalence of bronchiectasis was found by chest computed tomography (CT) in patients with moderate-severe chronic obstructive pulmonary disease (COPD), and it was shown to be associated with more severe symptoms, higher frequency of exacerbations and mortality. The risk factors for bronchiectasis in COPD are not yet clarified.High-resolution computed tomography (HRCT) of chest was performed in patients with moderate-severe COPD, and the presence and the extent of bronchiectasis were evaluated by two radiologists...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27348199/the-multiple-faces-of-non-cystic-fibrosis-bronchiectasis-a-cluster-analysis-approach
#15
Miguel Á Martínez-García, Montserrat Vendrell, Rosa Girón, Luis Máiz-Carro, David de la Rosa Carrillo, Javier de Gracia, Casilda Olveira
RATIONALE: The clinical presentation and prognosis of non-cystic fibrosis bronchiectasis are both very heterogeneous. OBJECTIVES: To identify different clinical phenotypes for non-cystic fibrosis bronchiectasis and their impact on prognosis. METHODS: Using a standardized protocol, we conducted a multicenter observational cohort study at six Spanish centers with patients diagnosed with non-cystic fibrosis bronchiectasis before December 31, 2005, with a 5-year follow-up from the bronchiectasis diagnosis...
September 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27336790/phenotyping-adults-with-non-cystic-fibrosis-bronchiectasis-a-10-year-cohort-study-in-a-french-regional-university-hospital-center
#16
Matthieu Buscot, Héloïse Pottier, Charles-Hugo Marquette, Sylvie Leroy
BACKGROUND: Data concerning phenotypes in bronchiectasis are scarce. OBJECTIVE: The aim of this study was to describe the clinical, functional and microbiological phenotypes of patients with bronchiectasis. METHODS: A monocentric retrospective study in a university hospital in France was conducted over 10 years (2002-2012). Non-cystic fibrosis patients with tomographic confirmation of bronchiectasis were included. The clinical, functional and microbiological data of patients were analyzed relying on the underlying etiology...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27328637/longitudinal-follow-up-of-chronic-pulmonary-manifestations-in-esophageal-atresia-a-clinical-algorithm-and-review-of-the-literature
#17
Virginia Mirra, Marco Maglione, Laida L Di Micco, Silvia Montella, Francesca Santamaria
In the past decades improved surgical techniques and better neonatal supportive care have resulted in reduced mortality of patients with esophageal atresia (EA), with or without tracheoesophageal fistula, and in increased prevalence of long-term complications, especially respiratory manifestations. This integrative review describes the techniques currently used in the pediatric clinical practice for assessing EA-related respiratory disease. We also present a novel algorithm for the evaluation and surveillance of lung disease in EA...
May 29, 2016: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/27321896/aetiology-of-bronchiectasis-in-adults-a-systematic-literature-review
#18
Yong-Hua Gao, Wei-Jie Guan, Shao-Xia Liu, Lei Wang, Juan-Juan Cui, Rong-Chang Chen, Guo-Jun Zhang
While identifying the underlying aetiology is a key part of bronchiectasis management, the prevalence and impact of identifying the aetiologies on clinical management remain unclear. We aimed to determine the etiological spectrum of bronchiectasis, and how often etiological assessment could lead to the changes in patients' management. A comprehensive search was conducted using MEDLINE (via PubMed) and EMBASE for observational studies published before October 2015 reporting aetiologies in adults with bronchiectasis...
June 19, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27215505/lung-transplantation-for-non-cystic-fibrosis-bronchiectasis
#19
Jessica Rademacher, Felix C Ringshausen, Hendrik Suhling, Jan Fuge, Georg Marsch, Gregor Warnecke, Axel Haverich, Tobias Welte, Jens Gottlieb
BACKGROUND: Lung transplantation (LTx) is a well-established treatment for end-stage pulmonary disease. However, data regarding microbiology and outcome of patients with non-cystic fibrosis bronchiectasis (NCFB) after lung transplantation are limited. METHODS: A retrospective analysis between August 1992 and September 2014 of all patients undergoing lung transplantation at our program of all recipients with a primary diagnosis of bronchiectasis was performed. Microbiology of sputum and bronchoalveolar lavage specimens, lung function and clinical parameters pre- and post-LTx were assessed retrospectively...
June 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27143532/-perioperative-mortality-of-lung-transplantation-in-chronic-obstructive-pulmonary-disease
#20
José Cerón Navarro, Karol de Aguiar Quevedo, Carlos Jordá Aragón, Juan C Peñalver Cuesta, Nuria Mancheño Franch, Francisco Vera Sempere, José Padilla Alarcón
INTRODUCTION: Lung transplantation (LT) has been considered an alternative therapeutic approach in terminal patients. However, this process in COPD is not controversy-free. This paper aimed to analyze 30-day mortality (PM) patterns and their risk factors in COPD patients undergoing LT. PATIENTS AND METHOD: A retrospective cohort with 107 COPD patients, transplanted at the University La Fe Valencia, Spain, treated from January 1991 to December 2008. Demographics values, degree of dyspnoea, diagnosis, BODE index, single versus bilateral LT, cardio-pulmonary bypass, donor age, steroid dependence, presence of bronchiectasis, retrograde perfusion, transfusion of blood products, and PaO2/FiO2 were analyzed...
June 17, 2016: Medicina Clínica
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