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pea addiction

Julia M Post, Sebastian Loch, Raissa Lerner, Floortje Remmers, Ermelinda Lomazzo, Beat Lutz, Laura Bindila
Research on the antiepileptic effects of (endo-)cannabinoids has remarkably progressed in the years following the discovery of fundamental role of the endocannabinoid (eCB) system in controlling neural excitability. Moreover, an increasing number of well-documented cases of epilepsy patients exhibiting multi-drug resistance report beneficial effects of cannabis use. Pre-clinical and clinical research has increasingly focused on the antiepileptic effectiveness of exogenous administration of cannabinoids and/or pharmacologically induced increase of eCBs such as anandamide (also known as arachidonoylethanolamide [AEA])...
2018: Frontiers in Molecular Neuroscience
Emma Zambrana-Infantes, Cristina Rosell Del Valle, David Ladrón de Guevara-Miranda, Pablo Galeano, Estela Castilla-Ortega, Fernando Rodríguez De Fonseca, Eduardo Blanco, Luis Javier Santín
Cocaine addiction is a chronically relapsing disorder characterized by compulsive drug-seeking and drug-taking behaviors. Previous studies have demonstrated that cocaine, as well as other drugs of abuse, alters the levels of lipid-based signaling molecules, such as N-acylethanolamines (NAEs). Moreover, brain levels of NAEs have shown sensitivity to cocaine self-administration and extinction training in rodents. Given this background, the aim of this study was to investigate the effects of repeated or acute administration of palmitoylethanolamide (PEA), an endogenous NAE, on psychomotor sensitization and cocaine-induced contextual conditioning...
March 2018: Pharmacology, Biochemistry, and Behavior
Beata Bystrowska, Irena Smaga, Małgorzata Frankowska, Małgorzata Filip
Preclinical investigations have demonstrated that drugs of abuse alter the levels of lipid-based signalling molecules, including endocannabinoids (eCBs) and N-acylethanolamines (NAEs), in the rodent brain. In addition, several drugs targeting eCBs and/or NAEs are implicated in reward and/or seeking behaviours related to the stimulation of dopamine systems in the brain. In our study, the brain levels of eCBs (anandamide (AEA) and 2-arachidonoylglycerol (2-AG)) and NAEs (oleoylethanolamide (OEA) and palmitoylethanolamide (PEA)) were analyzed via an LC-MS/MS method in selected brain structures of rats during cocaine self-administration and after extinction training according to the "yoked" control procedure...
April 3, 2014: Progress in Neuro-psychopharmacology & Biological Psychiatry
Maria Scherma, Zuzana Justinová, Claudio Zanettini, Leigh V Panlilio, Paola Mascia, Paola Fadda, Walter Fratta, Alexandros Makriyannis, Subramanian K Vadivel, Islam Gamaleddin, Bernard Le Foll, Steven R Goldberg
BACKGROUND AND PURPOSE: The fatty acid amide hydrolase inhibitor URB597 can reverse the abuse-related behavioural and neurochemical effects of nicotine in rats. Fatty acid amide hydrolase inhibitors block the degradation (and thereby magnify and prolong the actions) of the endocannabinoid anandamide (AEA), and also the non-cannabinoid fatty acid ethanolamides oleoylethanolamide (OEA) and palmitoylethanolamide (PEA). OEA and PEA are endogenous ligands for peroxisome proliferator-activated receptors alpha (PPAR-α)...
April 2012: British Journal of Pharmacology
Joseph M Galante, Salman Ahmad, Elizabeth A Albers, Matthew J Sena
BACKGROUND: The prevalence of drug or alcohol addiction among trauma patients approaches 40%, yet many require narcotics during admission for adequate pain control. Provider awareness is the most reasonable option to avoid the devastating consequence of narcotic tablet injection. OBJECTIVE: To illustrate the misuse of oral narcotics and to heighten provider awareness of a potential cause for acute respiratory failure in recently discharged patients. CASE REPORT: A 20-year-old man was admitted to the hospital after an assault to the head and face...
September 2012: Journal of Emergency Medicine
Alfredo Ramos-Miguel, Susana Esteban, Jesús A García-Sevilla
Drugs of abuse induce behavioral neuroadaptations whose molecular mechanisms, partly known, are crucial to understanding drug addictions. The multifunctional adaptor Fas-associated protein with death domain (FADD) was recently associated with the induction of neuroplasticity. This study investigated the modulation of FADD and MAP kinase signaling, as well as their interactions with PEA-15 (phosphoprotein enriched in astrocytes-15 kDa) and Akt1 pathways, during the expression of unconditioned morphine-induced psychomotor sensitization...
January 2010: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Li-Feng Wang, Yong Zhou, Yan-Ming Xu, Xiu-Chun Qiu, Ben-Gen Zhou, Fang Wang, Hua Long, Xiang Chen, Tong-Tao Yang, Bao-An Ma, Qing-Yu Fan, An-Gang Yang
Human growth factor receptor-2 (HER2), overexpressed as a result of gene amplification, is detected in 20-40% of patients with breast, ovarian, endometrial, gastric, bladder, prostate, or lung cancers, correlated to metastasis of many tumors, and considered to be a poor prognostic indicator for these tumors. However, the data was controversial for HER2 overexpression and the prognosis of osteosarcoma, which is the most common primary malignant bone tumor, presents a therapeutic challenge in medical oncology due to its metastasis and poor response to current treatments...
August 2009: Cancer Investigation
A Ramos-Miguel, M J García-Fuster, L F Callado, R La Harpe, J J Meana, J A García-Sevilla
Fas-associated protein with death domain (FADD) is a multifunctional protein that can induce both apoptotic and non-apoptotic actions. Recently, FADD was found downregulated in the prefrontal cortex of opiate abusers, which suggested an attenuation of Fas death signals in human addicts. Phosphorylation of FADD (Ser194) has been reported to regulate its non-apoptotic activity, which might include the induction of neuroplastic effects in the brain. This postmortem brain study examined the status of phosphorylated (p)-Ser194 FADD and signaling pathways involved in neuroplasticity in the prefrontal cortex (BA 9) of short-term (ST) and long-term (LT) heroin or methadone abusers...
June 16, 2009: Neuroscience
M Kathleen Holmes, Carrie E Bearden, Marcela Barguil, Manoela Fonseca, E Serap Monkul, Fabiano G Nery, Jair C Soares, Jim Mintz, David C Glahn
BACKGROUND: Elevated levels of impulsivity and increased risk taking are thought to be core features of both bipolar disorder (BD) and addictive disorders. Given the high rates of comorbid alcohol abuse in BD, alcohol addiction may exacerbate impulsive behavior and risk-taking propensity in BD. Here we examine multiple dimensions of impulsivity and risk taking, using cognitive tasks and self-report measures, in BD patients with and without a history of alcohol abuse. METHODS: Thirty-one BD subjects with a prior history of alcohol abuse or dependence (BD-A), 24 BD subjects with no history of alcohol abuse/dependence (BD-N), and 25 healthy control subjects (HC) were assessed with the Barratt Impulsiveness Scale (BIS) and the computerized Balloon Analogue Risk Task (BART)...
February 2009: Bipolar Disorders
Miriam Melis, Giuliano Pillolla, Antonio Luchicchi, Anna Lisa Muntoni, Sevil Yasar, Steven R Goldberg, Marco Pistis
Nicotine stimulates the activity of mesolimbic dopamine neurons, which is believed to mediate the rewarding and addictive properties of tobacco use. Accumulating evidence suggests that the endocannabinoid system might play a major role in neuronal mechanisms underlying the rewarding properties of drugs of abuse, including nicotine. Here, we investigated the modulation of nicotine effects by the endocannabinoid system on dopamine neurons in the ventral tegmental area with electrophysiological techniques in vivo and in vitro...
December 17, 2008: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Mauro Federici, Raffaella Geracitano, Alessandro Tozzi, Patrizia Longone, Silvia Di Angelantonio, C Peter Bengtson, Giorgio Bernardi, Nicola B Mercuri
Trace amines (TAs) are present in the central nervous system in which they up-regulate catecholamine release and are implicated in the pathogenesis of addiction, attention-deficit/hyper-activity disorder, Parkinson's disease, and schizophrenia. By using intracellular and patch-clamp recordings from dopaminergic cells in the rat midbrain slices, we report a depressant postsynaptic action of two TAs, beta-phenylethylamine (beta-PEA) and tyramine (TYR) on the GABA(B)-mediated slow inhibitory postsynaptic potential and baclofen-activated outward currents...
April 2005: Molecular Pharmacology
J E Salvaggio
The Columbian Exchange has been described as "the most important event in human history since the end of the Ice Age." This interchange of many species of fauna, flora, fowl, and fruits resulted in new encounters between New and Old World inhabitants. Prominent among these were manifestations of allergic reactions to many of the new substances. Little imagination is required to reflect on what these substances, added to or detracted from both the New and Old World lifestyles, habits, and diets. The numerous peas, vegetable seeds, and grasses, such as sugarcane, introduced during Columbus' later voyages, made an enormous difference in the lives of New World inhabitants, as did the introduction of the cow and horse, not to mention substances such as coconuts and bananas, that are now intimately associated with the Caribbean and the Bahamas...
November 1992: Allergy Proceedings: the Official Journal of Regional and State Allergy Societies
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