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https://www.readbyqxmd.com/read/27905893/computational-prediction-of-multidisciplinary-team-decision-making-for-adjuvant-breast-cancer-drug-therapies-a-machine-learning-approach
#1
Frank P Y Lin, Adrian Pokorny, Christina Teng, Rachel Dear, Richard J Epstein
BACKGROUND: Multidisciplinary team (MDT) meetings are used to optimise expert decision-making about treatment options, but such expertise is not digitally transferable between centres. To help standardise medical decision-making, we developed a machine learning model designed to predict MDT decisions about adjuvant breast cancer treatments. METHODS: We analysed MDT decisions regarding adjuvant systemic therapy for 1065 breast cancer cases over eight years. Machine learning classifiers with and without bootstrap aggregation were correlated with MDT decisions (recommended, not recommended, or discussable) regarding adjuvant cytotoxic, endocrine and biologic/targeted therapies, then tested for predictability using stratified ten-fold cross-validations...
December 1, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27900174/physical-and-functional-outcomes-following-multidisciplinary-residential-rehabilitation-for-prearthritic-hip-pain-among-young-active-uk-military-personnel
#2
Russell J Coppack, James L Bilzon, Andrew K Wills, Ian M McCurdie, Laura K Partridge, Alastair M Nicol, Alexander N Bennett
BACKGROUND: There are no studies describing the clinical outcomes of a residential, multidisciplinary team (MDT) rehabilitation intervention for patients with prearthritic hip pain. The aim of this cohort study was to describe the functional and physical outcomes of multidisciplinary residential rehabilitation for UK military personnel with prearthritic hip pain. METHODS: Participants (N=40) with a mean age of 33 years referred to a specialist residential rehabilitation centre completed a comprehensive multidisciplinary residential intervention...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27884783/secondary-multidrug-efflux-pump-mutants-alter-escherichia-coli-biofilm-growth-in-the-presence-of-cationic-antimicrobial-compounds
#3
Denice C Bay, Carol A Stremick, Carmine J Slipski, Raymond J Turner
Escherichia coli possesses many secondary active multidrug resistance transporters (MDTs) that confer overlapping substrate resistance to a broad range of antimicrobials via proton and/or sodium motive force. It is uncertain whether redundant MDTs uniquely alter cell survival when cultures grow planktonically or as biofilms. In this study, the planktonic and biofilm growth and antimicrobial resistance of 13 E. coli K-12 single MDT gene deletion strains in minimal and rich media were determined. Antimicrobial tolerance to tetracycline, tobramycin and benzalkonium were also compared for each ΔMDT strain...
November 22, 2016: Research in Microbiology
https://www.readbyqxmd.com/read/27882444/genomic-characterization-of-a-wild-bird-origin-pigeon-paramyxovirus-type-1-ppmv-1-first-isolated-in-the-northwest-region-of-china
#4
Xinglong Wang, Shanhui Ren, Xiangwei Wang, Chong Yang Wang, Mengfei Fan, Yanqing Jia, Xiaolong Gao, Huan Liu, Sa Xiao, Zengqi Yang
Pigeon paramyxovirus type-1(PPMV-1) is an enzootic in pigeon flocks and causes severe economic losses in the poultry industry in many countries. A PPMV-1 isolate, abbreviated as PPMV-1/QL-01/CH/15, was isolated from a great spotted woodpecker in the northwest region of China in 2015. The complete genome was sequenced, and the results showed that the virus genome was 15,192 nt in length, in the gene arrangement 3'-NP-P-M-F-HN-L-5'. Several amino acid mutations were identified in the functional domains of the F and HN proteins...
November 23, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27872113/does-integrated-care-reduce-hospital-activity-for-patients-with-chronic-diseases-an-umbrella-review-of-systematic-reviews
#5
Sarah Damery, Sarah Flanagan, Gill Combes
OBJECTIVE: To summarise the evidence regarding the effectiveness of integrated care interventions in reducing hospital activity. DESIGN: Umbrella review of systematic reviews and meta-analyses. SETTING: Interventions must have delivered care crossing the boundary between at least two health and/or social care settings. PARTICIPANTS: Adult patients with one or more chronic diseases. DATA SOURCES: MEDLINE, Embase, ASSIA, PsycINFO, HMIC, CINAHL, Cochrane Library (HTA database, DARE, Cochrane Database of Systematic Reviews), EPPI-Centre, TRIP, HEED, manual screening of references...
November 21, 2016: BMJ Open
https://www.readbyqxmd.com/read/27871330/age-is-not-a-determinant-factor-in-susceptibility-of-broilers-to-h5n2-clade-2-3-4-4-high-pathogenicity-avian-influenza-virus
#6
Kateri Bertran, Dong-Hun Lee, Charles Balzli, Mary J Pantin-Jackwood, Erica Spackman, David E Swayne
In 2014-2015, the US experienced an unprecedented outbreak of H5 clade 2.3.4.4 highly pathogenic avian influenza (HPAI) virus. The H5N2 HPAI virus outbreak in the Midwest in 2015 affected commercial turkey and layer farms, but not broiler farms. To assess any potential genetic resistance of broilers and/or age-related effects, we investigated the pathogenesis and transmission of A/turkey/Minnesota/12582/2015 (H5N2) (Tk/MN/15) virus in commercial 5-week-old broilers, 8-week-old broilers, and >30-week-old broiler breeders...
November 21, 2016: Veterinary Research
https://www.readbyqxmd.com/read/27851766/ultrasonography-of-leprosy-neuropathy-a-longitudinal-prospective-study
#7
Helena Barbosa Lugão, Marco Andrey Cipriani Frade, Wilson Marques-Jr, Norma Tiraboschi Foss, Marcello Henrique Nogueira-Barbosa
BACKGROUND: Previous studies have shown that leprosy multi-drug therapy (MDT) does not stop the progression of nerve function impairment. There are no prospective studies investigating the evolution of nerve anatomic abnormalities after treatment. We examined leprosy patients aiming to investigate the evolution of nerve ultrasonography (US) abnormalities and the risk factors for poor outcomes after MDT. METHODOLOGY/PRINCIPAL FINDINGS: We performed bilateral US of the ulnar (U), median (M) and common fibular (CF) nerves in 9 paucibacillary (PB) and 64 multibacillary (MB) patients before and after MDT...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27836568/the-surgical-management-of-head-and-neck-sarcoma-the-newcastle-experience
#8
R W F Breakey, T P Crowley, I B Anderson, R H Milner, M Ragbir
INTRODUCTION: Head and neck sarcomas are rare and difficult to manage surgically. Factors that influence the prognosis include the type and grade of tumour, resection margins, the anatomical site and patient-specific parameters. We review our experience as plastic surgeons working in a bone and soft-tissue tumour multidisciplinary team (MDT) in managing these tumours surgically. METHODS: Data on all patients with sarcoma of the head or neck managed surgically from 2004 to 2015 was reviewed...
October 5, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27830370/perceptual-distortion-of-the-tongue-by-lingual-nerve-block-and-topical-application-of-capsaicin-in-healthy-women
#9
Mika Honda, Lene Baad-Hansen, Takashi Iida, Lilja Kristín Dagsdóttir, Osamu Komiyama, Misao Kawara, Peter Svensson
OBJECTIVES: The aim of this study was to examine reports of perceptual distortion evoked by transient deafferentation and burning pain as models of aspects of burning mouth syndrome (BMS). MATERIALS AND METHODS: Sixteen healthy women took part in three experimental sessions that included exposure to lingual nerve block, capsaicin, and control substance. In each session, reported perceptual distortion and mechanical detection threshold (MDT) were assessed at four areas (the tongue, lower front teeth, lower lip, and right thumb) before and at 5, 15, 30 min and 1 and 3 h after the injection or application...
November 9, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27829869/interaction-between-thalamus-and-hippocampus-in-termination-of-amygdala-kindled-seizures-in-mice
#10
Zhen Zhang, Jia-Jia Li, Qin-Chi Lu, Hai-Qing Gong, Pei-Ji Liang, Pu-Ming Zhang
The thalamus and hippocampus have been found both involved in the initiation, propagation, and termination of temporal lobe epilepsy. However, the interaction of these regions during seizures is not clear. The present study is to explore whether some regular patterns exist in their interaction during the termination of seizures. Multichannel in vivo recording techniques were used to record the neural activities from the cornu ammonis 1 (CA1) of hippocampus and mediodorsal thalamus (MDT) in mice. The mice were kindled by electrically stimulating basolateral amygdala neurons, and Racine's rank standard was employed to classify the stage of behavioral responses (stage 1~5)...
2016: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/27826195/roles-and-challenges-of-the-multidisciplinary-team-involved-in-prosthetic-rehabilitation-in-a-rural-district-in-south-africa
#11
Liezel Ennion, Anthea Rhoda
BACKGROUND: Major lower limb amputations result in a significant sense of loss, psychological stress, and decrease in function and overall quality of life for the amputee. The holistic, patient-centered prosthetic rehabilitation of an amputee requires input from a team of dedicated health professionals from different disciplines commonly referred to as a multidisciplinary team (MDT). MDT rehabilitation is considered crucial in the reintegration of the amputee into the community, as well as for providing psychological support after limb loss...
2016: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/27821103/a-comparison-of-multidisciplinary-team-residential-rehabilitation-with-conventional-outpatient-care-for-the-treatment-of-non-arthritic-intra-articular-hip-pain-in-uk-military-personnel-a-protocol-for-a-randomised-controlled-trial
#12
Russell J Coppack, James L Bilzon, Andrew K Wills, Ian M McCurdie, Laura Partridge, Alastair M Nicol, Alexander N Bennett
BACKGROUND: Non-arthritic hip disorders are defined as abnormalities of the articulating surfaces of the acetabulum and femur before the onset of osteoarthritis, including intra-articular structures such as the acetabular labrum and chondral surfaces. Abnormal femoroacetabular morphology is commonly seen in young men who constitute much of the UK military population. Residential multidisciplinary team (MDT) rehabilitation for patients with musculoskeletal injuries has a long tradition in the UK military, however, there are no studies presenting empirical data on the efficacy of a residential MDT approach compared with individualised conventional outpatient treatment...
November 8, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27815753/pediatric-ethics-and-communication-excellence-peace-rounds-decreasing-moral-distress-and-patient-length-of-stay-in-the-picu
#13
Lucia Wocial, Veda Ackerman, Brian Leland, Brian Benneyworth, Vinit Patel, Yan Tong, Mara Nitu
This paper describes a practice innovation: the addition of formal weekly discussions of patients with prolonged PICU stay to reduce healthcare providers' moral distress and decrease length of stay for patients with life-threatening illnesses. We evaluated the innovation using a pre/post intervention design measuring provider moral distress and comparing patient outcomes using retrospective historical controls. Physicians and nurses on staff in our pediatric intensive care unit in a quaternary care children's hospital participated in the evaluation...
November 4, 2016: HEC Forum: An Interdisciplinary Journal on Hospitals' Ethical and Legal Issues
https://www.readbyqxmd.com/read/27813094/outcomes-of-patients-with-hepatocellular-carcinoma-are-determined-in-multidisciplinary-team-meetings
#14
Bérénice Charriere, Fabrice Muscari, Charlotte Maulat, Barbara Bournet, Delphine Bonnet, Christophe Bureau, Philippe Otal, Jean-Marie Peron, Bertrand Suc
BACKGROUND AND OBJECTIVES: To analyze overall survival (OS) rates for the three curative treatments of hepatocellular carcinoma (HCC) on an intention-to-treat (ITT) basis. METHODS: Cohort study based on data from a multidisciplinary team meeting (MDT) dedicated to HCC. From 2006 to 2013, we included every patient with newly diagnosed HCC, for whom curative treatment (liver transplantation (LT), radiofrequency ablation (RFA), surgical resection (SR)) was decided upon...
November 4, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27796776/hepatic-and-intra-abdominal-tuberculosis-2016-update
#15
REVIEW
Richard P T Evans, Moustafa Mabrouk Mourad, Lee Dvorkin, Simon R Bramhall
Mycobacterium tuberculosis (TB) infection affects nearly 10 million people a year and causes 1.5 million deaths. TB is common in the immunosuppressed population with 12 % of all new diagnoses occurring in human immune deficiency virus (HIV)-positive patients. Extra-pulmonary TB occurs in 12 % of patients with active TB infection of which 3.5 % is hepatobiliary and 6-38 % is intra-abdominal. Hepatobiliary and intra-abdominal TB can present with a myriad of non-specific symptoms, and therefore, diagnosis requires a high level of suspicion...
December 2016: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/27792719/-comparative-study-of-the-efficacy-of-larva-therapy-for-debridement-and-control-of-bacterial-burden-compared-to-surgical-debridement-and-topical-application-of-an-antimicrobial
#16
José Contreras-Ruiz, Adán Fuentes-Suárez, Sara Arroyo-Escalante, David Moncada-Barron, María Cristina Sosa-de-Martínez, Ernesto Maravilla-Franco, Judith Guadalupe Domínguez-Cherit
Maggot debridement therapy (MDT) is the use of medical grade maggots of the fly Lucilia sericata for wound debridement. Recent observations show that MDT decreases bacterial burden as well. Venous ulcers are the most commonly seen in wound clinics and require, besides adequate treatment of venous hypertension, proper wound bed preparation with debri dement of necrotic tissue and control of potential infections. To evaluate the efficacy of MDT in venous ulcers a randomized controlled trial was designed to compare MDT to surgical debridement and topical application of silver sulfadiazine (SSD) in 19 patients for 4 weeks...
October 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27785545/leprosy-with-ulnar-nerve-abscess-ultrasound-findings-in-a-child
#17
Helena Barbosa Lugão, Marco Andrey Cipriani Frade, Nilton Mazzer, Norma Tiraboschi Foss, Marcello Henrique Nogueira-Barbosa
We report the ultrasound findings of a typical case of nerve abscess due to leprosy in an 11-year-old boy. The patient had previously undergone pediatric multibacillary leprosy multidrug therapy (MDT) in accordance with World Health Organization guidelines. He presented to our service with bilateral ulnar neuritis with no response to prednisone (1 mg/kg). Right ulnar nerve ultrasound revealed nerve hypoechogenicity, fascicular pattern disorganization, marked fusiform thickening, and a round anechoic area suggestive of intraneural abscess...
October 27, 2016: Skeletal Radiology
https://www.readbyqxmd.com/read/27781375/multidisciplinary-management-of-hepatoblastoma-in-children-experience-from-a-developing-country
#18
Naresh Shanmugam, Julius Xavier Scott, Vimal Kumar, Mukul Vij, Priya Ramachandran, Gomathy Narasimhan, Mettu Srinivas Reddy, Venugopal Kota, Deenadayalan Munirathnam, Chayarani Kelgeri, Karthick Sundaram, Mohamed Rela
BACKGROUND: Advances in chemotherapy, liver resection techniques, and pediatric liver transplantation have vastly improved survival in children with hepatoblastoma (HB). These are best managed by a multidisciplinary team (MDT) in a setting where all treatment options are available. Until recently, this was difficult to achieve in India. METHODS: All children (<16 years) with HB treated in a pediatric liver surgery and transplantation unit between January 2011 and July 2016 were reviewed...
October 26, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27781248/-application-of-multidisciplinary-treatment-in-patients-with-liver-metastasis-of-colorectal-cancer
#19
Hao Li, Xiaohui Du, Shaoyou Xia, Songyan Li, Jian Xu, Guijun Zou, Shidong Hu
OBJECTIVE: To evaluate the application of multidisciplinary treatment (MDT) in patients with liver metastasis of colorectal cancer(CLM). METHODS: Clinical data of 118 patients with liver metastasis of colorectal cancer, including 32 patients with MDT (MDT group) and 86 patients without MDT (control group), from February 2014 to April 2015 in PLA General Hospital were analyzed retrospectively. Compliance of preoperative examination and adjuvant therapy, and efficacy-associated indexes were compared between the two groups...
October 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27772998/complex-genetic-test-requests-in-sa-an-mdt-approach
#20
Peter A Kaub, Karin S Kassahn, Janice M Fletcher
No abstract text is available yet for this article.
February 2016: Pathology
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