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https://www.readbyqxmd.com/read/29352753/factors-predicting-length-of-stay-following-bariatric-surgery-retrospective-review-of-a-single-uk-tertiary-centre-experience
#1
Fahad Mahmood, Alistair J Sharples, Adriana Rotundo, Nagammapudur Balaji, Vittal S R Rao
BACKGROUND: Laparoscopic Roux Y gastric bypass (RYGB) and laparoscopic sleeve gastrectomy (LSG) are the most commonly performed bariatric procedures. Improvement in techniques and perioperative management of patients have resulted in shorter hospital stay and reduced overall costs. Many post-operative protocols aspire to post-operative day 1 discharge with studies showing reduction in length of stay without increasing complications. In this study, we investigate the factors predictive of early discharge at our high-volume bariatric centre...
January 19, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29352403/micronized-zaleplon-delivery-via-orodispersible-film-and-orodispersible-tablets
#2
Prashanth Manda, Carmen Popescu, Abhishek Juluri, Karthik Janga, Praneeth Rao Kakulamarri, Sushmitha Narishetty, S Narasimha Murthy, Michael A Repka
The following research study focuses on improving the solubility of zaleplon (BCS class II drug) via micronization technique in order to enhance its oral delivery in orodispersible formulations. Zaleplon along with a surfactant solution was micronized by ultrasonication. The micronization process reduced the particle size of the crystalline drug about six-fold from its original size of 155.5 μm. The micronized zalepon dispersion was lyophilized to allow for a change in the state of matter (to a powder). The superior dissolution parameters (Q5, Q30, IDR, MDR, MDT, DE, and RDR) of zaleplon in microcrystalline form over the original crystalline form in in vitro dissolution studies had unraveled that micronization technique is an efficient tool in enhancing drug solubility...
January 19, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29339657/the-practical-management-of-chronic-pancreatitis-a-multidisciplinary-symposium-held-at-the-annual-meeting-of-the-pancreatic-society-of-great-britain-and-ireland-manchester-2016
#3
Santhalingam Jegatheeswaran, Joanne M Puleston, Sinead Duggan, Andrew Hart, Kevin C Conlon, Ajith K Siriwardena
AIM: This study is about a questionnaire survey of delegates attending the chronic pancreatitis symposium at the 2016 meeting of the Pancreatic Society of Great Britain and Ireland and seeks a multidisciplinary "snapshot" overview of practice. METHODS: A questionnaire was developed with multidisciplinary input. Questions on access to specialist care, methods of diagnosis and treatment including specific scenarios were incorporated. Eighty-three (66%) of 125 delegates effectively participated in this survey...
January 16, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29339194/vaginal-construction-and-treatment-providers-experiences-a-qualitative-analysis
#4
Katrina Roen, Sarah M Creighton, Peter Hegarty, Lih-Mei Liao
OBJECTIVE: To investigate specialist clinicians' experiences of treating vaginal agenesis. DESIGN: Semi-structured interviews. SETTING: 12 hospitals in Sweden and the UK. SAMPLE: 32 health professionals connected to multidisciplinary teams including medical specialists and psychologists. METHODS: Theoretical thematic analysis of recorded verbatim data. RESULTS: The gynecologist and psychologist interviewees share certain observations including the importance of psychological readiness for and appropriate timing of treatment...
January 12, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29336138/psycho-acoustical-measures-in-individuals-with-congenital-visual-impairment
#5
Kaushlendra Kumar, Teenu Thomas, Jayashree S Bhat, Rajesh Ranjan
INTRODUCTION: In congenital visual impaired individuals one modality is impaired (visual modality) this impairment is compensated by other sensory modalities. There is evidence that visual impaired performed better in different auditory task like localization, auditory memory, verbal memory, auditory attention, and other behavioural tasks when compare to normal sighted individuals. OBJECTIVE: The current study was aimed to compare the temporal resolution, frequency resolution and speech perception in noise ability in individuals with congenital visual impaired and normal sighted...
December 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/29328761/pancreatic-cancer-a-symptomless-killer
#6
Karen Gedge
Pancreatic cancer is the fifth most common cause of cancer death in the UK. This disease often remains undiagnosed until it is at a late stage, resulting in the majority of tumours being unsuitable for surgical resection. When a diagnosis of pancreatic cancer is confirmed, early input from the multi-disciplinary team (MDT) is vital. Due to the poor prognosis, the screening and treatment of pancreatic cancer remains a considerable challenge for medicine in the 21st century.
July 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29325348/-multidisciplinary-team-building-in-enhanced-recovery-after-surgery
#7
W D Jia
There has been 10 years to explore the road in line with China's actual enhanced recovery after surgery(ERAS) since Academician Li Jieshou introduced the view of ERAS into China. ERAS has been widely carried out in the field of surgery, and gradually formed with Chinese characteristics of ERAS clinical pathway.The clinical implementation of ERAS relies on the effective integration of a series of perioperative methods, and any single technique or method can't completely reduce the perioperative physiological and psychological traumatic stress of the patient, so as to achieve the patient's rapid rehabilitation patient-centered multidisciplinary team(MDT)collaboration is an inevitable trend in ERAS development...
January 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29302724/consensus-on-training-and-implementation-of-enhanced-recovery-after-surgery-a-delphi-study
#8
Nader K Francis, Thomas Walker, Fiona Carter, Martin Hübner, Angela Balfour, Dorthe Hjort Jakobsen, Jennie Burch, Tracy Wasylak, Nicolas Demartines, Dileep N Lobo, Valerie Addor, Olle Ljungqvist
BACKGROUND: Enhanced Recovery After Surgery (ERAS) is widely accepted in current surgical practice due to its positive impact on patient outcomes. The successful implementation of ERAS is challenging and compliance with protocols varies widely. Continual staff education is essential for successful ERAS programmes. Teaching modalities exist, but there remains no agreement regarding the optimal training curriculum or how its effectiveness is assessed. We aimed to draw consensus from an expert panel regarding the successful training and implementation of ERAS...
January 4, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29289558/retrospective-active-case-finding-in-cambodia-an-innovative-approach-to-leprosy-control-in-a-low-endemic-country
#9
Thomas Fürst, Arielle Cavaliero, Sambath Lay, Chrystel Dayer, Chan Saren, Ajda Smrekar, So Visal, Tanja Barth-Jaeggi, Peter Steinmann
Currently, leprosy control relies on the clinical diagnosis of leprosy and the subsequent administration of multidrug therapy (MDT). However, many health workers are not familiar with the cardinal signs of leprosy, particularly in low-endemic settings including Cambodia. In response, a new approach to early diagnosis was developed in the country, namely retrospective active case finding (RACF) through small mobile teams. In the frame of RACF, previously diagnosed leprosy patients are traced and their contacts screened through "drives"...
December 28, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29288182/implementation-of-a-lung-cancer-multidisciplinary-team-standardised-template-for-reporting-to-general-practitioners-a-mixed-method-study
#10
Nicole M Rankin, Gemma K Collett, Clare M Brown, Tim J Shaw, Kahren M White, Philip J Beale, Lyndal J Trevena, Cleola Anderiesz, David J Barnes
OBJECTIVES: Few interventions have been designed that provide standardised information to primary care clinicians about the diagnostic and treatment recommendations resulting from cancer multidisciplinary team (MDT) (tumour board) meetings. This study aimed to develop, implement and evaluate a standardised template for lung cancer MDTs to provide clinical information and treatment recommendations to general practitioners (GPs). Specific objectives were to (1) evaluate template feasibility (acceptability, appropriateness and timeliness) with GPs and (2) document processes of preimplementation, implementation and evaluation within the MDT setting...
December 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/29286623/microwave-activated-mn-doped-zirconium-metal-organic-frameworks-nanocubes-for-highly-effective-combination-of-microwave-dynamic-and-thermal-therapy-against-cancer
#11
Changhui Fu, Hongqiao Zhou, Longfei Tan, Zhongbing Huang, Qiong Wu, Xiangling Ren, Jun Ren, Xianwei Meng
Developing functional nanoagents for achieving the combination of microwave dynamic therapy (MDT) and thermal therapy (MTT) is highly desirable due to the advantages of improving the therapeutic effect of the tumor and minimizing the side effect. Metal-organic frameworks (MOFs), as emerging porous materials, exhibit many intriguing properties for application in biomedicine. Herein, a new-style flexible Mn-doped zirconium metal-organic frameworks (Mn-ZrMOF) nanocubes (NCs) with the average size of about 60 nm were prepared easily by one-pot hydrothermal method...
December 29, 2017: ACS Nano
https://www.readbyqxmd.com/read/29282505/impact-of-a-multidisciplinary-team-approach-for-managing-advanced-and-recurrent-colorectal-cancer
#12
Sung Min Jung, Yong Sang Hong, Tae Won Kim, Jin-Hong Park, Jong Hoon Kim, Seong Ho Park, Ah Young Kim, Seok-Byung Lim, Young-Joo Lee, Chang Sik Yu
BACKGROUND: The wide variety of treatment strategies makes clinical decision-making difficult in advanced and recurrent colorectal cancer cases. Many hospitals have started multidisciplinary team (MDT) meetings comprising a team of dedicated specialists for discussing cases. MDTs for selected cases that are difficult to diagnose and treat are alternatives to regular MDTs. This study's aim was to determine the impact of a MDT for colorectal cancer on clinical decision-making. METHODS: Cases were discussed when clinical specialists had difficulty making decisions alone...
December 27, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29280112/-multidisciplinary-team-approach-in-diagnosis-and-treatment-of-patients-with-chronic-constipation
#13
Zhixue Fang, Zhongcheng Huang
Chronic constipation is one of the common diseases in clinic. For the complicated causes and pathophysiology, the overall efficacy is not satisfactory in the traditional medical model. Multidisciplinary-team (MDT) approach is a new team medical model, which is also an important systematic and modular medical approach. Treating patients with chronic constipation by multidisciplinary-team approach is an effective way to improve the overall efficacy. In diagnosis, MDT approach can get more accurate and explicit diagnosis and type of the constipation by gathering patients' detailed medical history, complete physical examination, laboratory and image test, patients' mental and nutritional condition...
December 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29274303/magnetic-drug-targeting-simulations-in-blood-flows-with-fluid-structure-interaction
#14
S Calandrini, G Capodaglio, E Aulisa
We present fluid-structure interaction (FSI) simulations of magnetic drug targeting (MDT) in blood flows. In this procedure, a drug is attached to ferromagnetic particles in order to externally direct it to a specific target after it is injected inside the body. The goal is to minimize the healthy tissue affected by the treatment and to maximize the number of particles that reach the target location. MDT has been studied both experimentally and theoretically by several authors. In recent years, computational fluid dynamics (CFD) simulations of MDT in blood flows have been carried out to obtain further insight on the combination of parameters that provide the best capture efficiency...
December 23, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29273008/implementation-of-guidelines-for-multidisciplinary-team-management-of-pregnancy-in-women-with-pre-existing-diabetes-or-cardiac-conditions-results-from-a-uk-national-survey
#15
Cath Taylor, David R McCance, Lucy Chappell, Catherine Nelson-Piercy, Sara A Thorne, Khaled M K Ismail, James S A Green, Debra Bick
BACKGROUND: Despite numerous publications stating the importance of multidisciplinary care for women with pre-existing medical conditions, there is a lack of evidence regarding structure or processes of multidisciplinary working, nor impact on maternal or infant outcomes. This study aimed to evaluate the implementation of guidelines for multidisciplinary team (MDT) management in pregnant women with pre-existing diabetes or cardiac conditions. These conditions were selected as exemplars of increasingly common medical conditions in pregnancy for which MDT management is recommended to prevent or reduce adverse maternal and fetal outcomes...
December 22, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29261176/-not-pathogenic-until-proven-otherwise-perspectives-of-uk-clinical-genomics-professionals-toward-secondary-findings-in-context-of-a-genomic-medicine-multidisciplinary-team-and-the-100-000-genomes-project
#16
Elizabeth Ormondroyd, Michael P Mackley, Edward Blair, Judith Craft, Julian C Knight, Jenny C Taylor, John Taylor, Hugh Watkins
PurposeApproaches to secondary findings in genome sequencing (GS) are unresolved. In the United Kingdom, GS is now routinely available through the 100,000 Genomes Project, which offers participants feedback of limited secondary findings.MethodsIn Oxford, a Genomic Medicine Multidisciplinary Team (GM-MDT) governs local access to GS, and reviews findings. Semistructured interviews were conducted with 19 GM-MDT members to explore perspectives on secondary findings.ResultsWhile enthusiastic about GS for diagnosing rare disease, members question the rationale for genome screening largely because of lack of evidence for clinical utility and limited justification for use of resources...
October 26, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29259378/impact-of-homogeneous-pathologic-response-to-preoperative-chemotherapy-in-patients-with-multiple-colorectal-liver-metastases
#17
Charles Sabbagh, Denis Chatelain, Christophe Attencourt, Jean-Paul Joly, Bruno Chauffert, Cyril Cosse, Jean-Marc Regimbeau
AIM: To analyze the homogeneity of pathologic response to preoperative chemotherapy (PRPC) after chemotherapy in patients with multiple liver metastases (LM). METHODS: From September 2011 to August 2014, patients with at least two LM undergoing preoperative chemotherapy prior to resection were included in this retrospective, single-center study. The endpoints were PRPC homogeneity (according to both the Rubbia-Brandt and MD Anderson classifications), the impact of PRPC on the MDT decision, factors associated with homogeneous PRPC and overall survival of patients with vs...
December 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29246588/immediate-reporting-of-chest-x-rays-referred-from-general-practice-by-reporting-radiographers-a-single-centre-feasibility-study
#18
N Woznitza, K Piper, S Rowe, A Bhowmik
AIM: To investigate the feasibility of radiographer-led immediate reporting of chest radiographs (CXRs) referred from general practice. MATERIALS AND METHODS: This 4-month feasibility study (November 2016 to March 2017) was carried out in a single radiology department at an acute general hospital. Comparison was made between CXRs that received an immediate and routine report to determine the number of lung cancers diagnosed, time to diagnosis of lung cancer, time to computed tomography (CT), and number of urgent referrals to respiratory medicine...
December 12, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29244970/maggot-debridement-therapy-for-an-electrical-burn-injury-with-instructions-for-the-use-of-lucilia-sericata-larvae
#19
A Nasoori, R Hoomand
OBJECTIVE: Maggot debridement therapy (MDT) has proved an efficient and reliable approach for wound healing. We explain the use of maggots with a stepwise procedure for conducting MDT in a patient with severe and large electrical wounds. METHOD: We captured the flies of Lucilia sericata from the natural environment, Alborz, Iran, and reared them in netted cages. The eggs obtained from the flies were disinfected with chloramine, and then were incubated on culture medium...
December 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29240541/surveillance-or-metastasis-directed-therapy-for-oligometastatic-prostate-cancer-recurrence-a-prospective-randomized-multicenter-phase-ii-trial
#20
Piet Ost, Dries Reynders, Karel Decaestecker, Valérie Fonteyne, Nicolaas Lumen, Aurélie De Bruycker, Bieke Lambert, Louke Delrue, Renée Bultijnck, Tom Claeys, Els Goetghebeur, Geert Villeirs, Kathia De Man, Filip Ameye, Ignace Billiet, Steven Joniau, Friedl Vanhaverbeke, Gert De Meerleer
Purpose Retrospective studies suggest that metastasis-directed therapy (MDT) for oligorecurrent prostate cancer (PCa) improves progression-free survival. We aimed to assess the benefit of MDT in a randomized phase II trial. Patients and Methods In this multicenter, randomized, phase II study, patients with asymptomatic PCa were eligible if they had had a biochemical recurrence after primary PCa treatment with curative intent, three or fewer extracranial metastatic lesions on choline positron emission tomography-computed tomography, and serum testosterone levels > 50 ng/mL...
December 14, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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