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Pragnan Kancharla, B K Surapaneni, M Goldfinger, K Hennrick, David J Ozeri
Anti-neutrophil cytoplasmic antibodies (ANCA) play an important role in the pathogenesis of pauci-immune renal vasculitis. However, in 10% of the cases, ANCA are absent. We present a case of a 64-year-old man with a chronic untreated hepatitis C virus infection and Middle Eastern thalassemia who was ANCA-negative when he was hospitalized due to acute kidney injury and accounts for an uncommon presentation of renal vasculitis. The patient had earlier reported to have undergone local lobectomy and adjuvant chemotherapy (carboplatin/pemetrexed) for lung adenocarcinoma a month prior...
May 2018: Case Reports in Oncology
Poorni M Manohar, Lauren J Beesley, Emily L Bellile, Francis P Worden, Anca M Avram
PURPOSE: There are no standardized prognostication algorithms for metastatic radioiodine-refractory (RAI-R) differentiated thyroid cancer (DTC). We hypothesize that [F]-FDG PET/CT may predict progression versus stability of disease based on quantitative analysis of metabolic tumor volume (MTV) and total lesion glycolysis (TLG). METHODS: Retrospective study of 62 patients with metastatic RAI-R DTC to determine clinical outcomes with median follow-up from initial diagnosis of 11...
July 14, 2018: Clinical Nuclear Medicine
Carmen De Jesús-Gil, Ester Ruiz-Romeu, Marta Ferran, Anca Chiriac, Gustavo Deza, Péter Hóllo, Antonio Celada, Ramon M Pujol, Luis F Santamaria-Babí
Streptococcus pyogenes throat infection is a clinically relevant trigger of both guttate and chronic plaque psoriasis, and it provides an ideal context in which to study the pathogenesis of these diseases using an antigen-dependent approach. Circulating cutaneous lymphocyte-associated antigen (CLA) positive (+) memory T cells are a subset of peripheral lymphocytes whose phenotype and function are related to immunological mechanisms in the skin. These cells are considered peripheral biomarkers of T-cell-mediated skin diseases...
2018: Frontiers in Immunology
Dana Vlascici, Nicoleta Plesu, Gheorghe Fagadar-Cosma, Anca Lascu, Mihaela Petric, Manuela Crisan, Anca Belean, Eugenia Fagadar-Cosma
Pt(II) 5,10,15,20-tetra(4-methoxy-phenyl)-porphyrin (PtTMeOPP) was used in the construction of new ion-selective sensors. The potentiometric response characteristics (slope and selectivity) of iodide and bromide-selective electrodes based on (PtTMeOPP) metalloporphyrin in o -nitrophenyloctylether (NPOE), dioctylphtalate (DOP) and dioctylsebacate (DOS) plasticized poly(vinyl chloride) membranes are compared. The best results were obtained for the membranes plasticized with DOP and NPOE. The sensors have linear responses with near-Nernstian slopes toward bromide and iodide ions and good selectivity...
July 16, 2018: Sensors
Silvia Gutnik, Yann Thomas, Yanwu Guo, Janosch Stoecklin, Anca Neagu, Lionel Pintard, Jorge Merlet, Rafal Ciosk
The Notch signalling pathway is a conserved and widespread signalling paradigm, and its misregulation has been implicated in numerous disorders, including cancer. The output of Notch signalling depends on the nuclear accumulation of the Notch receptor intracellular domain (ICD). Using the Caenorhabditis elegans germline, where GLP-1/Notch-mediated signalling is essential for maintaining stem cells, we monitored GLP-1 in vivo We found that the nuclear enrichment of GLP-1 ICD is dynamic: while the ICD is enriched in germ cell nuclei during larval development, it is depleted from the nuclei in adult germlines...
July 16, 2018: Biology Open
Ismael Mora-Guzmán, Álvaro Valdés de Anca, Elena Martín-Pérez
No abstract text is available yet for this article.
July 16, 2018: Acta Chirurgica Belgica
Ioana Adriana Muntean, Ioana Corina Bocsan, Nicolae Miron, Anca Dana Buzoianu, Diana Deleanu
The aim of the study was the analysis of adhesion molecules' profile (ICAM-1, VCAM-1, and E-selectin) in patients with allergic rhinitis and the influence of H1 antihistamines on those markers. Seventy-nine patients with persistent allergic rhinitis (PAR) and 30 healthy volunteers were included in the study. The patients with PAR were treated with desloratadine 5 mg/day or levocetirizine 5 mg/day for 4 weeks. The clinical (rhinitis symptoms and total symptoms score (TSS), type of sensitization) and biological evaluation (total IgE, eosinophils, ICAM-1, VCAM-1, and E-selectin) as well as fractionate nitric oxide in exhaled air (FeNO) measurement was performed before and after treatment...
2018: Oxidative Medicine and Cellular Longevity
Eduardo Martín-Nares, Diego Zuñiga-Tamayo, Andrea Hinojosa-Azaola
We aimed to estimate the frequency of overlap of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with systemic autoimmune diseases. Retrospective single-center study to identify patients with AAV diagnosis and concomitant autoimmune systemic diseases, simultaneously, before or after the diagnosis of AAV. Sociodemographic characteristics, such as comorbidities; follow-up time; type of AAV; disease duration; relapses; treatment and response; clinical, serological, and histological characteristics; disease activity and damage; prognosis; dialysis requirements, and death were assessed...
July 14, 2018: Clinical Rheumatology
Nina-Sophie Schmidt-Hegemann, Christian Stief, Tak-Hyun Kim, Chukwuka Eze, Simon Kirste, Iosif Strouthos, Minglun Li, Wolfgang Schultze-Seemann, Harun Ilhan, Wolfgang Peter Fendler, Peter Bartenstein, Anca-Ligia Grosu, Ute Ganswindt, Claus Belka, Philipp T Meyer, Constantinos Zamboglou
Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) detects prostate cancer recurrence at low PSA levels. Radiotherapy with dose escalation to the former prostate bed has been associated with improved biochemical recurrence-free survival (BRFS). Thus, we hypothesized that PSMA PET/CT-guided salvage radiotherapy leads to improved BRFS. Methods: A total of 204 consecutive patients were referred for salvage radiotherapy following radical prostatectomy. PSMA PET/CT scans were performed and patients with PSA persistence (109 patients) or evidence of distant metastases (5 patients) were excluded from this analysis...
July 12, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Maria Karolina Jonsson, Aase Haj Hensvold, Monika Hansson, Anna-Birgitte Aga, Joseph Sexton, Linda Mathsson-Alm, Martin Cornillet, Guy Serre, Siri Lillegraven, Bjørg-Tilde Svanes Fevang, Anca Irinel Catrina, Espen Andre Haavardsholm
BACKGROUND: Anti-citrullinated protein antibody (ACPA) reactivities precede clinical onset of rheumatoid arthritis (RA), and it has been suggested that ACPA reactivities towards distinct target proteins may be associated with differences in RA phenotypes. We aimed to assess the prevalence of baseline ACPA reactivities in an inception cohort of patients with early RA, and to investigate their associations with disease activity, treatment response, ultrasound findings and radiographic damage...
July 13, 2018: Arthritis Research & Therapy
Masayoshi Harigai, Kenji Nagasaka, Koichi Amano, Masashi Bando, Hiroaki Dobashi, Tamihiro Kawakami, Kan Kishibe, Yohko Murakawa, Joichi Usui, Takashi Wada, Eiichi Tanaka, Eishu Nango, Takeo Nakayama, Michi Tsutsumino, Kunihiro Yamagata, Sakae Homma, Yoshihiro Arimua
OBJECTIVE: The Japan Research Committee for Intractable Vasculitis has fully revised the clinical practice guidelines (CPG) for the management of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) to improve and standardize the medical treatment of the disease in Japan. METHODS: The previous CPG was published in a classical review style in Japanese in 2012 and 2014. We adopted the Grading of Recommendations Assessment, Development and Evaluation system for this revision, and various stakeholders, including patients, participated in it...
July 13, 2018: Modern Rheumatology
Verónica Aguirre, Miriam Alvo, Leopoldo Ardiles, Alberto Fierro, Annelise Goecke, Mirentxu Iruretagoyena, Roberto Jalil, Loreto Massardo, Gonzalo P Méndez, Sergio Palma, Emilio Roessler, Francisco Silva, Andrés Wurgaft
Renal involvement is a frequent complication in antineutrophil cytoplasmic antibodies (ANCA)associated vasculitides, adding morbidity and mortality, such as chronic kidney disease and the need for renal replacement therapy. With the aim of reaching a consensus on relevant issues regarding the diagnosis, treatment and follow-up of patients with these diseases, the Chilean Societies of Nephrology and Rheumatology formed a working group that, based on a critical review of the available literature and their experience, raised and answered consensually a set of questions relevant to the subject...
February 2018: Revista Médica de Chile
Kenji Nagasaka, Masayoshi Harigai, Noboru Hagino, Akinori Hara, Tetsuya Horita, Taichi Hayashi, Mitsuyo Itabashi, Satoshi Ito, Yasuhiro Katsumata, Soko Kawashima, Taio Naniwa, Ken-Ei Sada, Eishu Nango, Takeo Nakayama, Michi Tsutsumino, Kunihiro Yamagata, Sakae Homma, Yoshihiro Arimura
OBJECTIVES: To provide evidence for the revision of clinical practice guideline (CPG) for the management of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) by the Japan Research Committee for Intractable Vasculitis. METHODS: PubMed, CENTRAL, and the Japan Medical Abstracts Society were searched for articles published between January 1994 and January 2015 to conduct systematic review (SR), and the quality of evidence was assessed with GRADE approach...
July 12, 2018: Modern Rheumatology
Xiao-Jing Sun, Min Chen, Ming-Hui Zhao
Sphingosine-1-phosphate (S1P) is a crucial regulator in vascular inflammation. Our recent study found that under pathophysiological concentration in active anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), S1P participated in MPO-ANCA-positive IgG-induced glomerular endothelial cell (GEnC) activation via a S1P receptor (S1PR)-dependent way. However, the downstream signalling pathways are not fully clear yet. In this study, we demonstrated that Rho guanosine triphosphatases (GTPases) signalling pathways, RhoA and Rac1 in particular, were implicated in MPO-ANCA-positive IgG-mediated GEnCs activation enhanced by pathophysiological concentration of S1P in AAV...
July 11, 2018: Journal of Cellular and Molecular Medicine
Emilian Georgescu, Anca Oancea, Florentina Georgescu, Alina Nicolescu, Elena Iulia Oprita, Lucian Vladulescu, Marius-Constantin Vladulescu, Florin Oancea, Sergiu Shova, Calin Deleanu
Stable Schiff bases containing a furoxan moiety are synthesized as single regioisomers by the reaction of 3-methyl-2-oxy-furazan-4-carbaldehydewith various amino compounds at room temperature. The structures of synthesized compounds were fully characterized by multinuclear NMR spectroscopy and X-ray crystallography. The effect of synthesized Schiff bases containing a furoxan moiety on biological generation of reactive oxygen species and nitric oxide in plant tissues was investigated for the first time by fluorescence microscopy and the released NO identified as nitrite with Griess reagent...
2018: PloS One
James M Williams, Manoj Parimi, Jamie Sutherell
Although the role of ANCA in infective endocarditis is unclear, Bartonella henselae has been implicated as the culprit in cases of PR3-ANCA positive subacute bacterial endocarditis (SBE) with glomerulonephritis. In this case, a Coombs-positive autoimmune hemolytic anemia and glomerulonephritis accompanied a PR3-ANCA positive SBE caused by Bartonella henselae .
July 2018: Clinical Case Reports
Mihaela Balas, Florian Dumitrache, Madalina Andreea Badea, Claudiu Fleaca, Anca Badoi, Eugenia Tanasa, Anca Dinischiotu
Magnetic nanoparticles offer multiple utilization possibilities in biomedicine. In this context, the interaction with cellular structures and their biological effects need to be understood and controlled for clinical safety. New magnetic nanoparticles containing metallic/carbidic iron and elemental silicon phases were synthesized by laser pyrolysis using Fe(CO)₅ vapors and SiH₄ gas as Fe and Si precursors, then passivated and coated with biocompatible agents, such as l-3,4-dihydroxyphenylalanine (l-DOPA) and sodium carboxymethyl cellulose (CMC-Na)...
July 5, 2018: Nanomaterials
April M Jorge, Ronald B Melles, Yuqing Zhang, Na Lu, Sharan K Rai, Lucy H Young, Karen H Costenbader, Rosalind Ramsey-Goldman, S Sam Lim, John M Esdaile, Ann E Clarke, M B Urowitz, Anca Askanase, Cynthia Aranow, Michelle Petri, Hyon Choi
BACKGROUND: Hydroxychloroquine (HCQ) retinopathy may be more common than previously recognized; recent ophthalmology guidelines have revised recommendations from ideal body weight (IBW)-based dosing to actual body weight (ABW)-based dosing. However, contemporary HCQ prescribing trends in the UK remain unknown. METHODS: We examined a UK general population database to investigate HCQ dosing between 2007 and 2016. We studied trends of excess HCQ dosing per ophthalmology guidelines (defined by exceeding 6...
July 5, 2018: Arthritis Research & Therapy
Mouhamad Nasser, Vincent Cottin
The respiratory system may be involved in all types of systemic vasculitis with varying significance and frequency. ANCA-associated vasculitis, including granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, and microscopic polyangiitis, affects the respiratory tract more commonly than other vasculitis types. Granulomatosis with polyangiitis is always associated with upper or lower respiratory tract involvement. Pulmonary and ENT involvements are the hallmark feature of the disease and are present in 90 and 80% of cases, respectively, with frequent skin or gastrointestinal involvement...
July 4, 2018: Respiration; International Review of Thoracic Diseases
Anca Dorhoi, Jonathan Jantsch, Norbert Reiling
No abstract text is available yet for this article.
July 2018: European Journal of Immunology
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