Andrea D'Amato, Silvia Prosperi, Paolo Severino, Vincenzo Myftari, Aurora Labbro Francia, Claudia Cestiè, Nicola Pierucci, Stefanie Marek-Iannucci, Marco Valerio Mariani, Rosanna Germanò, Francesca Fanisio, Carlo Lavalle, Viviana Maestrini, Roberto Badagliacca, Massimo Mancone, Francesco Fedele, Carmine Dario Vizza
Worsening heart failure (WHF) is a severe and dynamic condition characterized by significant clinical and hemodynamic deterioration. It is characterized by worsening HF signs, symptoms and biomarkers, despite the achievement of an optimized medical therapy. It remains a significant challenge in cardiology, as it evolves into advanced and end-stage HF. The hyperactivation of the neurohormonal, adrenergic and renin-angiotensin-aldosterone system are well known pathophysiological pathways involved in HF. Several drugs have been developed to inhibit the latter, resulting in an improvement in life expectancy...
January 26, 2024: International Journal of Molecular Sciences