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https://www.readbyqxmd.com/read/29648484/serum-periostin-levels-serve-as-a-biomarker-for-both-eosinophilic-airway-inflammation-and-fixed-airflow-limitation-in-well-controlled-asthmatics
#1
Kentaro Takahashi, Kazuyuki Meguro, Hirotoshi Kawashima, Daisuke Kashiwakuma, Shin-Ichiro Kagami, Shoichiro Ohta, Junya Ono, Kenji Izuhara, Itsuo Iwamoto
OBJECTIVE: Periostin, a matricellular protein, is produced from airway epithelial cells and lung fibroblasts by IL-13. It has been suggested that periostin is involved in allergic inflammation and fibrosis. However, the usefulness of serum periostin measurement in the assessment of airway inflammation and remodeling and management of asthmatic patients is still debated. We aimed to determine whether serum periostin levels reflect eosinophilic airway inflammation and airway remodeling in asthma...
April 12, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29627118/alveolar-and-bronchial-nitric-oxide-in-chronic-obstructive-pulmonary-disease-and-asthma-copd-overlap
#2
Bernardino Alcázar-Navarrete, Francisca Castellano Miñán, Pablo Santiago Díaz, Oliveiro Ruiz Rodríguez, Pedro J Romero Palacios
INTRODUCTION: Exhaled nitric oxide (FENO ) measurements differentiate COPD phenotypes from asthma-COPD overlap (ACO). To date, no study has been conducted to determine whether alveolar and bronchial components differ in this group of patients. METHODS: This was an observational cross-sectional study recruiting ambulatory COPD patients. FENO was measured, differentiating alveolar (CANO ) from bronchial (JawNO ) components using a multiple-flow technique. CANO and JawNO values were compared between eosinophilic COPD patients (defined as ≥ 300 eosinophils/μL in peripheral blood test, or ≥ 2% eosinophils or ≥ 3% eosinophils), and a linear regression analysis was performed to determine clinical and biological variables related to these measurements...
April 4, 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29575336/simultaneously-elevated-feno-and-blood-eosinophils-relate-to-asthma-morbidity-in-asthmatics-from-nhanes-2007-12
#3
Ida Mogensen, Kjell Alving, Tiago Jacinto, João A Fonseca, Christer Janson, Andrei Malinovschi
BACKGROUND: Fraction of exhaled nitric oxide (FeNO) and blood eosinophil (B-Eos) count are biomarkers for type 2 inflammation. However, they signal different inflammatory pathways. Simultaneously elevated, they are related to more asthma events in a general population and among younger asthmatics. OBJECTIVE: To investigate if simultaneously elevated FeNO and B-Eos relate to asthma outcomes and lung function among subjects with asthma at a wide age span, and how different cut offs for the markers affect these relations...
March 25, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29575179/sensitisation-to-minor-cat-allergen-components-is-associated-with-type-2-biomarkers-in-young-asthmatics
#4
N Tsolakis, A Malinovschi, L Nordvall, L Mattsson, J Lidholm, C Pedroletti, C Janson, M P Borres, K Alving
BACKGROUND: Cat allergy is a major trigger of asthma worldwide. Molecular patterns of cat sensitisation vary between individuals, but their relationship to inflammation in asthmatics has not been extensively studied. OBJECTIVE: To investigate the prevalence and levels of IgE antibodies against different cat allergen components and their relationship to type-2 inflammation and total IgE among young asthmatic subjects sensitised to furry animals. METHODS: Patients with asthma (age 10-35 years; n=266) and IgE sensitisation to cat, dog or horse extract (ImmunoCAP), were analysed for IgE to the cat allergen components Fel d 1 (secretoglobin), Fel d 2 (serum albumin), Fel d 4 and Fel d 7 (lipocalins)...
March 25, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29566971/the-mega-project-a-study-of-the-mechanisms-involved-in-the-genesis-and-disease-course-of-asthma-asthma-cohort-creation-and-long-term-follow-up
#5
Xavier Muñoz, María José Álvarez-Puebla, Ebymar Arismendi, Lourdes Arochena, María Del Pilar Ausín, Pilar Barranco, Irina Bobolea, Jose Antonio Cañas, Blanca Cardaba, Astrid Crespo, Victora Del Pozo, Javier Domínguez-Ortega, María Del Mar Fernandez-Nieto, Jordi Giner, Francisco Javier González-Barcala, Juan Alberto Luna, Joaquim Mullol, Iñigo Ojanguren, José María Olaguibel, César Picado, Vicente Plaza, Santiago Quirce, David Ramos, Manuel Rial, Christian Romero-Mesones, Francisco Javier Salgado, María Esther San-José, Silvia Sánchez-Diez, Beatriz Sastre, Joaquin Sastre, Lorena Soto, Montserrat Torrejón, Marisa Urnadoz, Luis Valdes, Antonio Valero, María Jesús Cruz
The general aim of this study is to create a cohort of asthma patients with varying grades of severity in order to gain greater insight into the mechanisms underlying the genesis and course of this disease. The specific objectives focus on various studies, including imaging, lung function, inflammation, and bronchial hyperresponsiveness, to determine the relevant events that characterize the asthma population, the long-term parameters that can determine changes in the severity of patients, and the treatments that influence disease progression...
March 19, 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29538544/between-occasion-repeatability-of-fractional-exhaled-nitric-oxide-measurements-in-children
#6
Kamil Barański, Jan E Zejda
The aim of the study was to assess short-term repeatability of measurements of fractional exhaled nitric oxide (FENO) and its correlates in children in the 6- to 9-year age bracket participating in a respiratory epidemiological survey. FENO was measured in two sessions one week apart in 101 children. Participants were divided into three groups: asymptomatic (n = 76); symptomatic (n = 14); and asthma (n = 11). Absolute and relative differences between the measurements, as well as concordance correlation coefficients, were used in order to assess repeatability...
January 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29524536/managing-asthma-in-pregnancy-map-trial-feno-levels-and-childhood-asthma
#7
Matthew Morten, Adam Collison, Vanessa E Murphy, Daniel Barker, Christopher Oldmeadow, John Attia, Joseph Meredith, Heather Powell, Paul D Robinson, Peter D Sly, Peter G Gibson, Joerg Mattes
BACKGROUND: The single-centre double-blind, randomised controlled Managing Asthma in Pregnancy (MAP) trial in Newcastle, Australia, compared a treatment algorithm using the fraction of exhaled nitric oxide (FeNO) in combination with asthma symptoms (FeNO group) against a treatment algorithm using clinical symptoms only (clinical group) in pregnant asthmatic women (ANZ Clinical Trials Registry, number 12607000561482). The primary outcome was a 50% reduction in asthma exacerbations during pregnancy in the FeNO group...
March 7, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29514111/effects-of-exposure-to-ambient-ultrafine-particles-on-respiratory-health-and-systemic-inflammation-in-children
#8
Sam Clifford, Mandana Mazaheri, Farhad Salimi, Wafaa Nabil Ezz, Bijan Yeganeh, Samantha Low-Choy, Katy Walker, Kerrie Mengersen, Guy B Marks, Lidia Morawska
It is known that ultrafine particles (UFP, particles smaller than 0.1 μm) can penetrate deep into the lungs and potentially have adverse health effects. However, epidemiological data on the health effects of UFP is limited. Therefore, our objective was to test the hypothesis that exposure to UFPs is associated with respiratory health status and systemic inflammation among children aged 8 to 11 years. We conducted a cross-sectional study among 655 children (43.3% male) attending 25 primary (elementary) schools in the Brisbane Metropolitan Area, Australia...
March 4, 2018: Environment International
https://www.readbyqxmd.com/read/29512366/clinical-course-and-factors-associated-with-asthma-control-in-children-under-control-based-asthma-management-a-prospective-study
#9
Qi Gao, Huijie Huang, Kang Zhu, Xiaoying Liu, Xiaoling Hou, Hui Guan, Yongge Liu, Deli Xin, Li Xiang, Kunling Shen, Xin Ni
In the current study, we sought to track the clinical course of children under control-based asthma management and focused on respiratory pathogens monitoring. We prospectively explored influencing factors for asthma control. 121 children with uncontrolled asthma between 3-14 years of age were recruited. Common respiratory pathogens were detected with pharyngeal swabs and serum aeroallergen-specific IgE was measured. Numeric asthma control scores, airway resistance and fractional concentrations of exhaled nitric oxide (FENO) were evaluated...
February 2018: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29508715/phenotyping-patients-with-chronic-cough-evaluating-the-ability-to-predict-the-response-to-anti-inflammatory-therapy
#10
Mahboobeh Haji Sadeghi, Caroline E Wright, Simon Hart, Michael Crooks, Alyn Morice
BACKGROUND: Whether the fraction of exhaled nitric oxide (FeNO) measurement can predict the response to anti-inflammatory treatment in chronic cough is unknown. OBJECTIVE: To explore whether the effectiveness of treatment with 10 mg of montelukast or 20 mg of prednisolone in patients with chronic cough is predicted by FeNO level. METHODS: In this randomized, open-label, controlled pilot study conducted in the Clinical Trial Unit in Castle Hospital in the United Kingdom, 50 nonsmoking patients with a cough that lasted more than 8 weeks were sequentially enrolled in the study...
March 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29501247/the-impact-of-aging-on-outpatients-with-asthma-in-a-real-world-setting
#11
Giorgio Ciprandi, Irene Schiavetti, Fabio L M Ricciardolo
BACKGROUND: Asthma is characterized by airway inflammation and bronchial hyperreactivity. It is conceived that aging may affect asthma characteristics, but this issue is still not completely clarified in clinical practice. OBJECTIVE: The present study investigated whether aging may affect some clinical and functional factors in outpatients with asthma visited in a real-world setting, such as clinical practice. METHODS: Globally, 391 outpatients (163 males, median age 47 years) with asthma were consecutively evaluated...
March 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29500848/acute-health-effects-of-desktop-3d-printing-fdm-using-abs-and-pla-materials-an-experimental-exposure-study-in-human-volunteers
#12
Ina Gümperlein, Elke Fischer, Gisela Dietrich-Gümperlein, Stefan Karrasch, Dennis Nowak, Rudolf A Jörres, Rudolf Schierl
3D printers are increasingly run at home. Nanoparticle emissions from those printers have been reported, which raises the question whether adverse health effects from ultrafine particles (UFP) can be elicited by 3D printers. We exposed 26 healthy adults in a single-blinded, randomized, cross-over design to emissions of a desktop 3D printer using fused deposition modeling (FDM) for one hour (high UFP-emitting acrylonitrile butadiene styrene (ABS) versus low-emitting polylactic acid (PLA)). Before and after exposures, cytokines (IL-1β, IL-6, TNF-α, INF-γ) and ECP in nasal secretions, exhaled nitric oxide (FeNO), urinary 8-isoprostaglandin F2α (8-iso PGF2α ) and self-reported symptoms were assessed...
March 3, 2018: Indoor Air
https://www.readbyqxmd.com/read/29462750/personal-exposure-to-fine-particles-pm-2-5-and-respiratory-inflammation-of-common-residents-in-hong-kong
#13
Zhanlan Fan, Vivian C Pun, Xiao-Cui Chen, Qiu Hong, Linwei Tian, Steven Sai-Hang Ho, Shun-Cheng Lee, Lap Ah Tse, Kin-Fai Ho
BACKGROUND: Given the lack of research on the personal exposure to fine particles (PM2.5 ) in Hong Kong, we examined the association between short-term personal exposure to PM2.5 and their constituents and inflammation in exhaled breath in a sample of healthy adult residents. METHOD: Forty-six participants underwent personal PM2.5 monitoring for averagely 6 days to obtain 276 samples. Fractional exhaled nitric oxide (FeNO), a biomarker of inflammation in exhaled breath, was measured at the end of each 24-h personal monitoring...
February 17, 2018: Environmental Research
https://www.readbyqxmd.com/read/29444361/environmental-exposure-to-polycyclic-aromatic-hydrocarbons-kitchen-ventilation-fractional-exhaled-nitric-oxide-and-risk-of-diabetes-among-chinese-females
#14
Jian Hou, Huizhen Sun, Yun Zhou, Youjian Zhang, Wenjun Yin, Tian Xu, Juan Cheng, Weihong Chen, Jing Yuan
Diabetes is related to exposure to polycyclic aromatic hydrocarbons (PAHs), inflammation in the body and housing characters. However, associations of urinary monohydroxy-PAHs (OH-PAHs) or fractional exhaled nitric oxide (FeNO) with diabetes risk in relation to housing characters are unclear. In this study, 2645 individuals were drawn from the baseline survey of the Wuhan-Zhuhai Cohort Study. Associations of diabetes with urinary OH-PAHs or FeNO among cooking participants were estimated using logistics regression models...
February 14, 2018: Indoor Air
https://www.readbyqxmd.com/read/29432042/relationship-between-upper-airway-diseases-exhaled-nitric-oxide-and-bronchial-hyperresponsiveness-to-methacholine
#15
Marina Lluncor, Pilar Barranco, Emerson-Daniel Amaya, Javier Domínguez-Ortega, Valentín López-Carrasco, Isabel Coman, Santiago Quirce
OBJECTIVE: The "united airway disease" concept is based on the bidirectional interaction between asthma and rhinitis. The aim of this study was to determine the relationship between upper airway diseases and bronchial hyperresponsiveness (BHR), as well as their association with the fractional concentration of exhaled nitric oxide (FeNO) and atopy in patients with persistent symptoms suggestive of asthma requiring methacholine challenge testing (MCT) to confirm asthma diagnosis...
February 12, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29413515/baseline-serum-cxcl10-and-il-12-levels-may-predict-severe-asthmatics-responsiveness-to-omalizumab
#16
Maho Suzukawa, Hisako Matsumoto, Nobuharu Ohshima, Hiroyuki Tashimo, Isao Asari, Tomoko Tajiri, Akio Niimi, Hiroyuki Nagase, Hirotoshi Matsui, Nobuyuki Kobayashi, Shunsuke Shoji, Ken Ohta
BACKGROUND: Omalizumab, a humanized anti-IgE monoclonal antibody, is the first molecularly targeted drug for severe asthmatics. However, responses to omalizumab vary widely among patients. OBJECTIVES: This study aimed to assess the potential of baseline serum cytokine levels as predictors of responsiveness to omalizumab. METHODS: Thirty-one patients with severe, persistent asthma were enrolled in this study and administered omalizumab for at least 1 year...
January 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29412429/association-between-fraction-of-exhaled-nitric-oxide-and-spirometry-data-and-clinical-control-of-asthma-in-children-and-adolescents
#17
Luanda Dias da Silva Salviano, Karla Delevedove Taglia-Ferre, Sandra Lisboa, Ana Carolina Carioca da Costa, Hisbello da Silva Campos, Maria de Fátima Pombo March
OBJECTIVE: To evaluate the association between fraction of exhaled nitric oxide (FeNO) values and forced expiratory volume in the first second (FEV1) and the level of asthma control, as proposed by the Global Initiative for Asthma (GINA), in asthmatic children and adolescents attended at the National Institute of Women, Children and Adolescents Health Fernandes Figueira of Fundação Oswaldo Cruz (IFF/FIOCRUZ). METHODS: This was a cross-sectional study, with a review of medical records of 90 asthmatics between 7 and 17 years old, who were followed up at the IFF/FIOCRUZ Asthma Outpatient Clinic and were referred to perform respiratory function tests (RFT)between March 2013 and September 2014...
January 15, 2018: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/29409487/heterogeneous-pattern-of-differences-in-respiratory-parameters-between-elderly-with-either-good-or-poor-fev1
#18
Stefan Karrasch, Jürgen Behr, Rudolf M Huber, Dennis Nowak, Annette Peters, Stefan Peters, Rolf Holle, Rudolf A Jörres, Holger Schulz
BACKGROUND: The relationship of spirometric values to other respiratory and functional parameters in advanced age is not well studied. We assessed this relationship in elderly subjects with either good or poor spirometric parameters to reveal whether different domains of lung function show comparable differences between the two groups. METHODS: Among subjects of the population-based KORA-Age cohort (n = 935, 65-90y; 51% male) two groups were selected from either the lower (LED; n = 51) or the upper (UED; n = 72) end of the FEV1 distribution...
February 6, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29408317/measurement-of-fractional-exhaled-nitric-oxide-in-real-world-clinical-practice-alters-asthma-treatment-decisions
#19
Nicola A Hanania, Marc Massanari, Neal Jain
BACKGROUND: Assessment of asthma using clinical measures alone often fails to detect underlying airway inflammation. Fractional exhaled nitric oxide (FeNO) is a recognized biomarker of type 2 airway inflammation in asthma. Measurement of FeNO is instrumental in the assessment and management of patients with corticosteroid-sensitive asthma. OBJECTIVE: To determine the impact of measuring FeNO on asthma management in real-world clinical practices. METHODS: Clinicians from 337 US practices performed a clinical assessment and recorded treatment plans before and after measuring FeNO in 7901 patients with asthma...
February 2, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29401500/mobile-direct-observation-of-therapy-mdot-a-rapid-systematic-review-and-pilot-study-in-children-with-asthma
#20
Michael D Shields, Fahad ALQahtani, Michael P Rivey, James C McElnay
We describe, for the first time, the use of a mobile device platform for remote direct observation of inhaler use and technique. The research programme commenced with a rapid systematic review of mobile device (or videophone) use for direct observation of therapy (MDOT). Ten studies (mainly pilots) were identified involving patients with tuberculosis, sickle cell disease and Alzheimer's disease. New studies are ongoing (ClinicalTrials.gov website) in TB, stroke, sickle cell disease, HIV and opioid dependence...
2018: PloS One
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