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https://www.readbyqxmd.com/read/29019007/evaluation-on-exposures-to-particulate-matter-at-a-junior-secondary-school-a-comprehensive-study-on-health-risks-and-effective-inflammatory-responses-in-northwestern-china
#1
Hongmei Xu, Benjamin Guinot, Steven Sai Hang Ho, Yaqi Li, Junji Cao, Zhenxing Shen, Xinyi Niu, Zhuohui Zhao, Suixin Liu, Yali Lei, Qian Zhang, Jian Sun
Air pollutant measurement and respiratory inflammatory tests were conducted at a junior secondary school in Xi'an, Northwestern China. Hazardous substances including particulate matters (PMs), black carbon (BC) and particle-bounded polycyclic aromatic hydrocarbons (PAHs) were quantified both indoors and outdoors of the school. Source characterization with organic tracers and particle-size distribution demonstrated that the school's air was mostly polluted by combustion emissions from the surrounding environment...
October 10, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28988796/nitrogen-dioxide-exposure-in-school-classrooms-of-inner-city-children-with-asthma
#2
Jonathan M Gaffin, Marissa Hauptman, Carter R Petty, William J Sheehan, Peggy S Lai, Jack M Wolfson, Diane R Gold, Brent A Coull, Petros Koutrakis, Wanda Phipatanakul
BACKGROUND: Ambient and home exposure to nitrogen dioxide (NO2) causes asthma symptoms and decreased lung function in children with asthma. Little is known about the health effects of school classroom pollution exposure. OBJECTIVE: We aimed to determine the effect of indoor classroom NO2 on lung function and symptoms of inner-city schoolchildren with asthma. METHODS: Children enrolled in the School Inner City Asthma Study were followed for one academic year...
October 5, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28987568/short-term-effects-of-various-ozone-metrics-on-cardiopulmonary-function-in-chronic-obstructive-pulmonary-disease-patients-results-from-a-panel-study-in-beijing-china
#3
Hongyu Li, Shaowei Wu, Lu Pan, Junhui Xu, Jiao Shan, Xuan Yang, Wei Dong, Furong Deng, Yahong Chen, Masayuki Shima, Xinbiao Guo
BACKGROUND: Short-term exposure to ambient air pollution has been associated with lower pulmonary function and higher blood pressure (BP). However, controversy remains regarding the relationship between ambient multiple daily ozone (O3) metrics and cardiopulmonary health outcomes, especially in the developing countries. OBJECTIVES: To investigate and compare the short-term effects of various O3 metrics on pulmonary function, fractional exhaled nitric oxide (FeNO) and BP in a panel study of COPD patients...
October 5, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28981975/lung-function-improvement-and-airways-inflammation-reduction-in-asthmatic-children-after-a-rehabilitation-program-at-moderate-altitude
#4
Eugen Bersuch, Florian Gräf, Ellen D Renner, Andreas Jung, Claudia Traidl-Hoffmann, Roger Lauener, Caroline Roduit
BACKGROUND: Rehabilitational programs at moderate altitude (1500m to 2500m) showed improvement of lung function and reduction of airways inflammation in asthmatic adults. Allergen avoidance was postulated as the major cause of these improvements. METHODS: Spirometries of 344 and fractional exhaled nitric oxide measurements (FeNO) of 124 asthmatic children and adolescents, staying in a rehabilitation hospital in Davos (1590m) with at least 14 days between admission and discharge, were analysed in associations with atopic sensitisation (skin-prick testing and/or specific IgE), level of asthma control, and inhalative corticosteroid (ICS) dose...
October 5, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28959121/inhaled-steroids-and-active-smoking-drive-chronic-obstructive-pulmonary-disease-symptoms-and-biomarkers-to-a-greater-degree-than-airflow-limitation
#5
Philip E Silkoff, Dave Singh, J Mark FitzGerald, Andreas Eich, Andrea Ludwig-Sengpiel, Geoffrey C Chupp, Vibeke Backer, Celeste Porsbjerg, Pierre-Olivier Girodet, Mark T Dransfield, Frederic Baribaud, Vedrana S Susulic, Matthew J Loza
RATIONALE: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease, and development of novel therapeutics requires an understanding of pathophysiologic phenotypes. OBJECTIVES: The purpose of the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study was to correlate clinical features and biomarkers with molecular characteristics in a well-profiled COPD cohort. METHODS: A total of 67 COPD subjects (forced expiratory volume in the first second of expiration [FEV1]: 45%-80% predicted) and 63 healthy smoking and nonsmoking controls underwent multiple assessments including patient questionnaires, lung function, and clinical biomarkers including fractional exhaled nitric oxide (FENO), induced sputum, and blood...
2017: Biomarker Insights
https://www.readbyqxmd.com/read/28952460/serum-and-exhaled-breath-condensate-leptin-levels-in-asthmatic-and-obesity-children-a-pilot-study
#6
A Bodini, L Tenero, M Sandri, C Maffeis, M Piazza, L Zanoni, D Peroni, A Boner, G Piacentini
BACKGROUND: Recent studies have highlighted the possible involvement of leptin in inflammation. The leptin receptor is also expressed by alveolar macrophages, T lymphocytes and bronchial epitelial cells, suggesting a possible role in the cascade of airway inflammation. OBJECTIVES: The aim of the study was to evaluate the levels of leptin in exhaled breath condensate (EBC) from asthmatic, normal- and overweight children, in relationship with airway inflammation. METHODS: 15 asthmatic non-obese children, 15 healthy non-asthmatic non-obese children, 11 obese children with asthma (OA) and 20 obese children without asthma (ONA) were enrolled...
September 27, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28949783/the-effect-of-bronchodilation-and-spirometry-on-fractional-exhaled-nitric-oxide-feno50-bronchial-no-flux-jawno-and-alveolar-no-concentration-cano-in-children-and-young-adults
#7
Theodoros Karampitsakos, Adonis Protopapas, Maria Gianoloudi, Vassileios P Papadopoulos, Demosthenes Bouros, Athanasios Chatzimichael, Emmanouil Paraskakis
OBJECTIVE: Fractional exhaled nitric oxide (FeNO), bronchial nitric oxide (JawNO) and alveoar nitric oxide (CANO) are biomarkers of eosinophilic inflammation, usually measured simultaneously with spirometry and bronchodilation. Our aim was to investigate the effect of bronchodilation and spirometry on FeNO, CANO and JawNO in children and young adults with well-controlled asthma and in healthy volunteers. METHODS: FeNO was measured in 95 subjects (62 controls, 33 asthmatics)...
September 26, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28944531/short-term-respiratory-effects-of-e-cigarettes-in-healthy-individuals-and-smokers-with-asthma
#8
Andreas S Lappas, Anna S Tzortzi, Efstathia M Konstantinidi, Stephanie I Teloniatis, Chara K Tzavara, Sofia A Gennimata, Nikolaos G Koulouris, Panagiotis K Behrakis
BACKGROUND AND OBJECTIVE: This study investigated the duration of immediate respiratory effects of e-cigarette smoking (ECS) and tested the hypothesis that ECS has more prominent effects in asthmatics compared with healthy smokers (HS). METHODS: Fifty-four smokers, 27 healthy (HS group) and 27 with intermittent asthma (mild asthma (MA) group) underwent a control session (no liquid, no resistor coil inside e-cigarette cartridge) and an experimental session of ECS using standardized puffing settings...
September 24, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28944471/a-composite-of-exhaled-ltb4-lxa4-feno-and-fev1-as-an-asthma-classification-ratio-characterizes-childhood-asthma
#9
Li-Chen Chen, Hsu-Min Tseng, Ming-Ling Kuo, Chih-Yung Chiu, Sui-Ling Liao, Kuan-Wen Su, Ming-Han Tsai, Man-Chin Hua, Shen-Hao Lai, Tsung-Chieh Yao, Kuo-Wei Yeh, Ai-Hsuan Wu, Jing-Long Huang, Shau-Ku Huang
BACKGROUND: Aberrant generation of eicosanoids is associated with asthma, but the evidence remains incomplete and its potential utility as biomarkers is unclear. Major eicosanoids in exhaled breath condensates (EBCs) were assessed as candidate markers for childhood asthma. METHODS: Ten exhaled eicosanoid species was evaluated using ELISA in the discovery phase, followed by prediction model-building and validation phases. RESULTS: Exhaled LTB4 , LTE4 , PGE2 and LXA4 showed significant difference between asthmatics (N=60) and controls (N=20)...
September 25, 2017: Allergy
https://www.readbyqxmd.com/read/28929816/which-inhaled-corticosteroid-and-long-acting-%C3%AE-agonist-combination-is-better-in-patients-with-moderate-to-severe-asthma-a-dry-powder-inhaler-or-a-pressurized-metered-dose-inhaler
#10
Masato Muraki, Kyuya Gose, Soichiro Hanada, Hirochiyo Sawaguchi, Yuji Tohda
Two main types of devices are used to facilitate the administration of inhaled corticosteroid (ICS) and long-acting β-agonist (LABA) in combination, dry powder inhalers (DPIs) and pressurized metered-dose inhalers (pMDIs). There are few reports comparing the effects of the two devices, and it is unknown which should be recommended for asthma patients with given sets of characteristics. In the current study, the beneficial effects and side effects associated with DPIs and pMDIs were compared, and the question of which device should be recommended for asthma patients was investigated...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28929293/predictive-biomarkers-for-asthma-therapy
#11
REVIEW
Sarah K Medrek, Amit D Parulekar, Nicola A Hanania
PURPOSE OF REVIEW: Asthma is a heterogeneous disease characterized by multiple phenotypes. Treatment of patients with severe disease can be challenging. Predictive biomarkers are measurable characteristics that reflect the underlying pathophysiology of asthma and can identify patients that are likely to respond to a given therapy. This review discusses current knowledge regarding predictive biomarkers in asthma. RECENT FINDINGS: Recent trials evaluating biologic therapies targeting IgE, IL-5, IL-13, and IL-4 have utilized predictive biomarkers to identify patients who might benefit from treatment...
September 19, 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28926855/a-comparison-of-the-efficacy-of-once-daily-fluticasone-furoate-vilanterole-with-twice-daily-fluticasone-propionate-salmeterol-in-elderly-asthmatics
#12
Yoshihisa Ishiura, Masaki Fujimura, Yasutaka Shiba, Noriyuki Ohkura, Johsuke Hara, Miki Abo, Kazuo Kasahara
Background Asthma in the elderly population has been focused because it affects quality of life and results in a higher hospitalization rate and mortality. Fluticasone furoate (FF)/vilanterole (VI) is a novel inhaled corticosteroids (ICS)/long-acting β2 agonist (LABA) combination being developed for once-daily administration for asthma with greater anti-inflammatory activity and longer duration of bronchidilation. The Ellipta(TM) dry powder inhaler (DPI) has also been available as a new device with high levels of satisfaction and preference...
September 19, 2017: Drug Research
https://www.readbyqxmd.com/read/28916487/a-novel-statistical-model-for-analyzing-data-of-a-systematic-review-generates-optimal-cut-off-values-for-fractional-exhaled-nitric-oxide-for-asthma-diagnosis
#13
REVIEW
Antonius Schneider, Klaus Linde, Johannes B Reitsma, Susanne Steinhauser, Gerta Rücker
OBJECTIVE: Measurement of fractional exhaled nitric oxide (FENO) might substitute bronchial provocation for diagnosing asthma. However, optimal FENO thresholds for diagnosing asthma remain unclear. We re-analyzed data collected for a systematic review investigating the diagnostic accuracy of FENO measurement to exploit all available thresholds under consideration of pre-test probabilities using a newly developed statistical model. STUDY DESIGN: 150 data-sets for a total of 53 different cut-offs extracted from 26 studies with 4518 participants were analyzed with the multiple thresholds model...
September 12, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28915873/a-prospective-cohort-study-on-ambient-air-pollution-and-respiratory-morbidities-including-childhood-asthma-in-adolescents-from-the-western-cape-province-study-protocol
#14
Toyib Olaniyan, Mohamed Jeebhay, Martin Röösli, Rajen Naidoo, Roslynn Baatjies, Nino Künzil, Ming Tsai, Mark Davey, Kees de Hoogh, Dilys Berman, Bhawoodien Parker, Joy Leaner, Mohamed Aqiel Dalvie
BACKGROUND: There is evidence from existing literature that ambient air pollutant exposure in early childhood likely plays an important role in asthma exacerbation and other respiratory symptoms, with greater effect among asthmatic children. However, there is inconclusive evidence on the role of ambient air pollutant exposures in relation to increasing asthma prevalence as well as asthma induction in children. At the population level, little is known about the potential synergistic effects between pollen allergens and air pollutants since this type of association poses challenges in uncontrolled real life settings...
September 16, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28913990/association-between-sensitization-to-mold-and-impaired-pulmonary-function-in-children-with-asthma
#15
Jung Hye Byeon, Soohyun Ri, Oyuntulga Amarsaikhan, Eunji Kim, So Hyun Ahn, Ic Sun Choi, Hyung Jin Kim, SungChul Seo, Wonsuck Yoon, Young Yoo
PURPOSE: Recent data indicate that sensitization to mold contributes to the severity and persistence of asthma. In this study, we investigated the relationships between sensitization to mold and lung function parameters in children with asthma. METHODS: We retrospectively reviewed clinical data from 551 asthmatic subjects. We selected subjects who met clinical diagnostic criteria of asthma. Their spirometry, methacholine challenge tests, and measurements of blood eosinophils, serum IgE, eosinophil cationic protein (ECP) and fractional exhaled nitric oxide (FeNO) results were included...
November 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28899467/-clinical-significance-of-fractional-exhaled-nitric-oxide-combined-with-in-vitro-allergen-test-in-identifying-children-at-a-high-risk-of-asthma-among-those-with-recurrent-wheezing
#16
Wei-Peng Hou, Ya-Jie Wang, Li-Hong Qiao, Hui-Li Shen
OBJECTIVE: To investigate the clinical value of combined determination of in vitro allergens and fractional exhaled nitric oxide (FeNO) in indentifying children at a high risk of asthma among those with recurrent wheezing. METHODS: A total of 148 children with recurrent wheezing (0.5-6 years old) were enrolled as study subjects, and 80 healthy children who underwent physical examination were enrolled as the control group. Pharmacia UniCAP immunoassay analyzer was used to measure specific immunoglobulin E (sIgE)...
September 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28871585/exhaled-nitric-oxide-atopy-and-spirometry-in-asthma-and-rhinitis-patients-in-india
#17
Raj Kumar, Nitesh Gupta
INTRODUCTION: Asthma is a chronic airway inflammatory disorder. Nitric oxide (NO) is non-invasively measured in exhaled breath (FeNO). The aim of the study was to investigate the anthropometric and physiologic factors that influence FeNO measurements. Also, to evaluate FeNO correlation with spirometry and inflammatory markers in asthma and rhinitis. MATERIAL AND METHODS: The study was a prospective analysis of asthma (BA) and rhinitis (AR) in patients enrolled from outpatient clinics between 2011 and 2015...
2017: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/28860527/relationship-between-fraction-of-exhaled-nitric-oxide-and-airway-morphology-assessed-by-three-dimensional-ct-analysis-in-asthma
#18
Koji Nishimoto, Masato Karayama, Naoki Inui, Kazutaka Mori, Masato Kono, Hironao Hozumi, Yuzo Suzuki, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Hiroshi Watanabe, Takafumi Suda
Fraction of exhaled nitric oxide (FeNO) provides information about chronic inflammation in asthma. However, its relationship with structural changes in the airways is unknown. We aimed to evaluate the correlation between computer-based airway changes and FeNO in patients with asthma. The wall area (WA) and airway inner luminal area (Ai) of the third- to sixth-generation bronchi were measured using three-dimensional computed tomography in asthmatic patients. Each value was corrected by body surface area (BSA)...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28846444/validity-of-fractional-exhaled-nitric-oxide-and-small-airway-function-indices-in-diagnosis-of-cough-variant-asthma
#19
Chen Feng-Jia, Huang Xin-Yan, Lin Geng-Peng, Liu Yang-Li, Xie Can-Mao
BACKGROUND: Fractional exhaled nitric oxide (FeNO) is a non-invasive method used to reveal the eosinophilic inflammation of airway and to diagnose and manage asthma. The diagnostic value of FeNO in patients with cough variant asthma (CVA) is poorly understood. Small airways remain an important aspect of CVA. The use of FeNO measurement or its combination with the small airway function in differentiating CVA patients from chronic cough patients is unexplored. METHODS: From December 2012 to June 2016, patients with chronic nonproductive cough for more than 8 weeks without any wheezing or dyspnea, fever or blood-stained sputum, and abnormalities on X-ray or larger airways function based on physician's opinion were subjected to FeNO, pulmonary function, and bronchial hyperresponsiveness (BHR) tests...
August 28, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28843617/model-based-clinical-pharmacology-profiling-and-exposure-response-relationships-of-the-efficacy-and-biomarker-of-lebrikizumab-in-patients-with-moderate-to-severe-asthma
#20
Rui Zhu, Yanan Zheng, Nathanael L Dirks, Shweta Vadhavkar, Jin Yan Jin, Kun Peng, Cecile T J Holweg, Julie Olsson, John G Matthews, Wendy S Putnam
Lebrikizumab is a humanized monoclonal antibody that binds to interleukin-13 and has been evaluated as a treatment for moderate-to-severe asthma. Objectives of this work were to characterize lebrikizumab pharmacokinetics (PK), identify influential covariates, and graphically explore exposure-response relationships in moderate-to-severe asthmatics. Pooled PK data from 11 studies were used in the population PK model development. Full covariate modeling was used to evaluate the impact of pre-specified covariates...
October 2017: Pulmonary Pharmacology & Therapeutics
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