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https://www.readbyqxmd.com/read/29444361/environmental-exposure-to-polycyclic-aromatic-hydrocarbons-kitchen-ventilation-fractional-exhaled-nitric-oxide-and-risk-of-diabetes-among-chinese-females
#1
Jian Hou, Huizhen Sun, Yun Zhou, Youjian Zhang, Wenjun Yin, Tian Xu, Juan Cheng, Weihong Chen, Jing Yuan
Diabetes is related to exposure to polycyclic aromatic hydrocarbons (PAHs), inflammation in the body and housing characters. However, associations of urinary monohydroxy-PAHs (OH-PAHs) or fractional exhaled nitric oxide (FeNO) with diabetes risk in relation to housing characters are unclear. In this study, 2645 individuals were drawn from the baseline survey of the Wuhan-Zhuhai Cohort Study. Associations of diabetes with urinary OH-PAHs or FeNO among cooking participants were estimated using logistics regression models...
February 14, 2018: Indoor Air
https://www.readbyqxmd.com/read/29432042/relationship-between-upper-airway-diseases-exhaled-nitric-oxide-and-bronchial-hyperresponsiveness-to-methacholine
#2
Marina Lluncor, Pilar Barranco, Emerson-Daniel Amaya, Javier Domínguez-Ortega, Valentín López-Carrasco, Isabel Coman, Santiago Quirce
OBJECTIVE: The "united airway disease" concept is based on the bidirectional interaction between asthma and rhinitis. The aim of this study was to determine the relationship between upper airway diseases and bronchial hyperresponsiveness (BHR), as well as their association with the fractional concentration of exhaled nitric oxide (FeNO) and atopy in patients with persistent symptoms suggestive of asthma requiring methacholine challenge testing (MCT) to confirm asthma diagnosis. METHODS: A cross-sectional prospective study was carried out in adult patients with persistent asthma-like symptoms and negative bronchodilator testing...
February 12, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29413515/baseline-serum-cxcl10-and-il-12-levels-may-predict-severe-asthmatics-responsiveness-to-omalizumab
#3
Maho Suzukawa, Hisako Matsumoto, Nobuharu Ohshima, Hiroyuki Tashimo, Isao Asari, Tomoko Tajiri, Akio Niimi, Hiroyuki Nagase, Hirotoshi Matsui, Nobuyuki Kobayashi, Shunsuke Shoji, Ken Ohta
BACKGROUND: Omalizumab, a humanized anti-IgE monoclonal antibody, is the first molecularly targeted drug for severe asthmatics. However, responses to omalizumab vary widely among patients. OBJECTIVES: This study aimed to assess the potential of baseline serum cytokine levels as predictors of responsiveness to omalizumab. METHODS: Thirty-one patients with severe, persistent asthma were enrolled in this study and administered omalizumab for at least 1 year...
January 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29412429/association-between-fraction-of-exhaled-nitric-oxide-and-spirometry-data-and-clinical-control-of-asthma-in-children-and-adolescents
#4
Luanda Dias da Silva Salviano, Karla Delevedove Taglia-Ferre, Sandra Lisboa, Ana Carolina Carioca da Costa, Hisbello da Silva Campos, Maria de Fátima Pombo March
OBJECTIVE: To evaluate the association between fraction of exhaled nitric oxide (FeNO) values and forced expiratory volume in the first second (FEV1) and the level of asthma control, as proposed by the Global Initiative for Asthma (GINA), in asthmatic children and adolescents attended at the National Institute of Women, Children and Adolescents Health Fernandes Figueira of Fundação Oswaldo Cruz (IFF/FIOCRUZ). METHODS: This was a cross-sectional study, with a review of medical records of 90 asthmatics between 7 and 17 years old, who were followed up at the IFF/FIOCRUZ Asthma Outpatient Clinic and were referred to perform respiratory function tests (RFT)between March 2013 and September 2014...
January 15, 2018: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/29409487/heterogeneous-pattern-of-differences-in-respiratory-parameters-between-elderly-with-either-good-or-poor-fev1
#5
Stefan Karrasch, Jürgen Behr, Rudolf M Huber, Dennis Nowak, Annette Peters, Stefan Peters, Rolf Holle, Rudolf A Jörres, Holger Schulz
BACKGROUND: The relationship of spirometric values to other respiratory and functional parameters in advanced age is not well studied. We assessed this relationship in elderly subjects with either good or poor spirometric parameters to reveal whether different domains of lung function show comparable differences between the two groups. METHODS: Among subjects of the population-based KORA-Age cohort (n = 935, 65-90y; 51% male) two groups were selected from either the lower (LED; n = 51) or the upper (UED; n = 72) end of the FEV1 distribution...
February 6, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29408317/measurement-of-fractional-exhaled-nitric-oxide-in-real-world-clinical-practice-alters-asthma-treatment-decisions
#6
Nicola A Hanania, Marc Massanari, Neal Jain
BACKGROUND: Assessment of asthma using clinical measures alone often fails to detect underlying airway inflammation. Fractional exhaled nitric oxide (FeNO) is a recognized biomarker of type 2 airway inflammation in asthma. Measurement of FeNO is instrumental in the assessment and management of patients with corticosteroid-sensitive asthma. OBJECTIVE: To determine the impact of measuring FeNO on asthma management in real-world clinical practices. METHODS: Clinicians from 337 US practices performed a clinical assessment and recorded treatment plans before and after measuring FeNO in 7901 patients with asthma...
February 2, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29401500/mobile-direct-observation-of-therapy-mdot-a-rapid-systematic-review-and-pilot-study-in-children-with-asthma
#7
Michael D Shields, Fahad ALQahtani, Michael P Rivey, James C McElnay
We describe, for the first time, the use of a mobile device platform for remote direct observation of inhaler use and technique. The research programme commenced with a rapid systematic review of mobile device (or videophone) use for direct observation of therapy (MDOT). Ten studies (mainly pilots) were identified involving patients with tuberculosis, sickle cell disease and Alzheimer's disease. New studies are ongoing (ClinicalTrials.gov website) in TB, stroke, sickle cell disease, HIV and opioid dependence...
2018: PloS One
https://www.readbyqxmd.com/read/29398244/race-and-ethnicity-have-significant-influence-on-fractional-exhaled-nitric-oxide
#8
Dong Wang, Yanning Wang, Hong Liang, John E David, Christopher L Bray
BACKGROUND: Race and ethnicity have been shown to influence fractional exhaled nitric oxide (FeNO). There is a need to investigate cutoff points for different races and ethnicities to improve clinical application. OBJECTIVE: To investigate cutoff points for different races and ethnicities by analyzing the FeNO data collected by the National Health and Nutrition Examination Survey from 2007 to 2012. METHODS: This study included 23,433 participants...
February 1, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29395935/factors-reducing-omalizumab-response-in-severe-asthma
#9
B Sposato, M Scalese, M Milanese, S Masieri, C Cavaliere, M Latorre, N Scichilone, A Matucci, A Vultaggio, A Ricci, A Cresti, P Santus, A Perrella, P L Paggiaro
BACKGROUND: Despite adding Omalizumab to conventional therapy, several severe asthmatics still show poor disease control. We investigated the factors that may affect a reduced Omalizumab response in a large population of severe asthmatics. METHODS: 340 patients were retrospectively evaluated. FEV1%, FVC%, Asthma Control Test (ACT), fractional exhaled nitric oxide (FENO), possible step-downs/step-ups of concomitant therapies, exacerbations, disease control levels, ICS doses and SABA use, observed at the end of treatment, were considered as a response to Omalizumab...
January 29, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29382628/using-the-inflammacheck-device-to-measure-the-level-of-exhaled-breath-condensate-hydrogen-peroxide-in-patients-with-asthma-and-chronic-obstructive-pulmonary-disease-the-exhale-pilot-study-protocol-for-a-cross-sectional-feasibility-study
#10
Daniel M Neville, Carole Fogg, Thomas P Brown, Thomas L Jones, Eleanor Lanning, Paul Bassett, Anoop J Chauhan
BACKGROUND: Asthma and Chronic Obstructive Pulmonary Disease (COPD) are common conditions that affect over 5 million people in the United Kingdom. These groups of patients suffer significantly from breathlessness and recurrent exacerbations that can be difficult to diagnose and go untreated. A common feature of COPD and asthma is airway inflammation that increases before and during exacerbations. Current methods of assessing airway inflammation can be invasive, difficult to perform, and are often inaccurate...
January 30, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29379542/clinical-and-immunological-effects-of-vitamin-d-supplementation-during-the-pollen-season-in-children-with-allergic-rhinitis
#11
Joanna Jerzyńska, Włodzimierz Stelmach, Błażej Rychlik, Paweł Majak, Daniela Podlecka, Katarzyna Woicka-Kolejwa, Iwona Stelmach
Introduction: Vitamin D deficiency has been proposed as a potential contributing factor in patients with allergic diseases. We compared the clinical and immunological effects of vitamin D supplementation to placebo during the pollen season in children with allergic rhinitis. Material and methods: Thirty-eight children aged 5-12, sensitive to grass pollen, participated in a prospective, randomized, double-blind, placebo-controlled trial. Children received either vitamin D 1000 IU daily supplementation or placebo...
January 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29377450/absence-of-serum-ige-antibodies-indicates-non-type-2-disease-in-young-asthmatics
#12
N Tsolakis, A Malinovschi, L Nordvall, C Janson, M P Borres, K Alving
BACKGROUND: Atopic asthma is associated with elevated type-2 biomarkers such as fraction of exhaled nitric oxide (FeNO) and blood eosinophil (B-Eos) count. However, increased type-2 markers have also been reported in traditionally-defined non-atopic asthma. OBJECTIVE: To determine a clinically useful level of IgE sensitisation for ruling out type-2 asthma. METHODS: Asthmatics (N = 408; age 10-35 years) were analysed using the multi-allergen tests Phadiatop and fx5 (ImmunoCAP)...
January 29, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29368419/utility-of-single-versus-multiple-breath-washout-in-adult-asthma
#13
S Kjellberg, E Viklund, P D Robinson, O Zetterström, A-C Olin, P Gustafsson
Nitrogen multiple breath washout (N2 MBW) is a sensitive method to identify peripheral airway involvement in asthma, but is a time-consuming test. The N2 vital capacity single breath (VC SBW) test offers greater time efficiency, but concordance with N2 MBW is poorly understood. The prevalence of peripheral airway abnormality was determined by N2 MBW and N2 SBW tests in 194 asthmatic subjects aged 18-1 years. N2 MBW data were related to findings in 400 healthy controls, aged 17-71 years, while N2 SBW data were compared to findings in 224 healthy controls, aged 15-65 years, to derive equipment-specific reference values...
January 24, 2018: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/29357478/a-new-role-for-the-exhaled-nitric-oxide-as-a-functional-marker-of-peripheral-airway-calibre-changes-a-theoretical-study
#14
Cyril Karamaoun, Benoit Haut, Alain Van Muylem
Though considered as an inflammation marker, exhaled nitric oxide (FENO) was shown to be sensitive to airway caliber changes to such an extent that it might be considered as a marker of them. It is thus important to understand how these changes and their localization mechanically affect the total NO flux penetrating the airway lumen (JawNO), and hence FENO, independently from any inflammatory status change. In this work, a new model was used. It simulates NO production, consumption and diffusion inside the airway epithelium, NO excretion from the epithelial wall into the airway lumen and, finally, its axial transport by diffusion and convection in the airway lumen...
January 11, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29348180/persistently-elevated-exhaled-nitric-oxide-fraction-is-associated-with-increased-risk-of-exacerbation-in-copd
#15
Bernardino Alcázar-Navarrete, Oliverio Ruiz Rodríguez, Pablo Conde Baena, Pedro José Romero Palacios, Alvar Agusti
Preventing the occurrence of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is a major therapeutic goal. We hypothesise that persistently increased levels of exhaled nitric oxide (FeNO) during follow-up can identify a group of COPD patients at higher risk of AECOPD.To test this hypothesis, we measured FeNO levels (HypAir FeNO®, Medisoft; Sorinnes, Belgium) prospectively in 226 clinically stable COPD outpatients at recruitment and during follow-up (at 6 and 12 months). Patients were stratified according to the number of visits with FeNO ≥20 ppb...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29328030/modern-approaches-to-fractional-exhaled-nitric-oxide-as-a-useful-biomarker-for-allergic-asthma-phenotyping-and-management
#16
N Mgaloblishvili, M Gotua
Asthma is a pathologically heterogeneous disease, consisting of several phenotypes. Different types of airway inflammation are the cornerstone feature of this condition. Fraction of nitric oxide in exhaled air (FENO) has been proposed as a noninvasive, specific biomarker for eosinophilic airway inflammation and has been shown to be elevated in patients with allergic asthma phenotype. More recent studies indicate that FeNO identifies T-helper cell type 2 (Th2)-mediated airway inflammation with a high predictive value for identifying inhaled corticosteroid (ICS) responsive airway inflammation...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29324380/estimated-individual-inhaled-dose-of-fine-particles-and-indicators-of-lung-function-a-pilot-study-among-chinese-young-adults
#17
Tian Xu, Jian Hou, Juan Cheng, Runbo Zhang, Wenjun Yin, Cheng Huang, Xiaochuan Zhu, Weihong Chen, Jing Yuan
Fine particle (PM2.5)-related lung damage has been reported in most studies regarding environmental or personal PM2.5 concentrations. To assess effects of personal PM2.5 exposures on lung function, we recruited 20 postgraduate students and estimated the individual doses of inhaled PM2.5 based on their microenvironmetal PM2.5 concentrations, time-activity patterns and refereed inhalation rates. During the period of seven consecutive days in each of the four seasons, we repeatedly measured the daily lung function parameters and airway inflammation makers such as fractional exhaled nitric oxide (FeNO) as well as systemic inflammation markers including interleukin-1β on the final day...
January 8, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29304558/reduction-of-feno-by-tap-water-and-carbonated-water-mouthwashes-magnitude-and-time-course
#18
Paul Guenther Lassmann-Klee, Tuula Lindholm, Markus Metsälä, Lauri Halonen, Anssi Raimo Antero Sovijärvi, Päivi Piirilä
Fractional exhaled nitric oxide (FENO) assesses eosinophilic inflammation of the airways, but FENO values are also influenced by oral nitric oxide (NO). The aim of this pilot study was to measure FENO and compare the effect of two different mouthwashes on FENO and analyse the duration of the effect. FENO was measured in 12 randomized volunteers (healthy or asthmatic subjects) with a NIOX VERO® analyser at an expiratory flow rate of 50 mL/s. After a baseline measurement, a mouthwash was performed either with tap water or carbonated water and was measured during 20 min in 2 min intervals...
January 5, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29301349/associations-of-serum-25-oh-d-concentrations-with-lung-function-airway-inflammation-and-common-cold-in-the-general-population
#19
Rachida Rafiq, Willemien Thijs, Robert Prein, Renate T de Jongh, Christian Taube, Pieter S Hiemstra, Renée de Mutsert, Martin den Heijer
Vitamin D is hypothesized to have a beneficial effect on lung function and respiratory infections. The aim of this study was to assess the relationship of serum 25-hydroxyvitamin D (25(OH)D) concentrations with lung function, airway inflammation and common colds. We performed a cross-sectional analysis in the Netherlands Epidemiology of Obesity (NEO) study, a population-based cohort study. We included participants with measurements of serum 25(OH)D, Forced Expiratory Volume in 1 s (FEV₁), Forced Vital Capacity (FVC), Fractional Exhaled Nitric Oxide (FeNO), and data on self-reported common colds (n = 6138)...
January 3, 2018: Nutrients
https://www.readbyqxmd.com/read/29296089/elevated-fractional-exhaled-nitric-oxide-and-blood-eosinophil-counts-are-associated-with-a-17q21-asthma-risk-allele-in-adult-subjects
#20
Elizabeth A Schwantes, Michael D Evans, Alex Cuskey, Alex Burford, Judith A Smith, Robert F Lemanske, Nizar N Jarjour, Sameer K Mathur
Background and objectives: Genome-wide association studies identified single-nucleotide polymorphisms (SNPs) at the 17q21 locus conferring increased risk for childhood-onset asthma. Little is known about how these SNPs impact adult asthma patients. We sought to examine an adult population for associations between rs7216389 (17q21-associated SNP) and features of asthma including fractional exhaled nitric oxide (FeNO), eosinophil counts, and age of asthma onset. Methods: Subjects were genotyped at SNP rs7216389...
2018: Journal of Asthma and Allergy
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