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https://www.readbyqxmd.com/read/28743086/effect-of-cinnamon-cinnamomum-verum-bark-essential-oil-on-the-halitosis-associated-bacterium-solobacterium-moorei-and-in-vitro-cytotoxicity
#1
Geneviève LeBel, Bruno Haas, Andrée-Ann Adam, Marie-Pier Veilleux, Amel Ben Lagha, Daniel Grenier
OBJECTIVES: Halitosis, also known as bad breath or oral malodour, is a condition affecting a large proportion of the population. Solobacterium moorei is a Gram-positive anaerobic bacterium that has been specifically associated with halitosis. In this study, we investigated the effects of essential oils, more particularly cinnamon bark oil, on growth, biofilm formation, eradication and killing, as well as hydrogen sulfide (H2S) production by S. moorei. METHODS: A broth microdilution assay was used to determine the antibacterial activity of essential oils...
July 12, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28743077/characterization-and-quantitative-analysis-of-phenolic-derivatives-in-longxuetongluo-capsule-by-hplc-dad-it-tof-ms
#2
Jing Sun, Yuelin Song, Hui Sun, Wenjing Liu, Yunfeng Zhang, Jiao Zheng, Qian Zhang, Yunfang Zhao, Wei Xiao, Pengfei Tu, Jun Li
Longxuetongluo Capsule (LTC), which is derived from the total phenolic extract of Chinese dragon's blood, has been proved to be safe as well as effective towards ischemic stroke. However, the effective material basis remains unclear. The present study thereby focused on the clarification of the qualitative and quantitative properties for the phenolic derivatives in LTC. Regarding homolog-focused chemical profiling, the mass fragmentation patterns of the primary subtypes of phenolic compounds such as homoisoflavanones, flavanes, chalcones, and flavonoid oligomers were summarized by assaying authentic references with hybrid ion trap time-of-flight mass spectrometry, and the chemical structures of 124 phenolic compounds, in total, were unambiguously or tentatively annotated in LTC by matching the accurate mass spectral profiles with the proposed mass cracking rules and those reference substances...
July 14, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28742973/role-of-vitamin-a-oral-supplementation-on-oxidative-stress-and-inflammatory-response-in-the-liver-of-trained-rats
#3
Lyvia Lintzmaier Petiz, Alice Kunzler, Rafael Calixto Bortolin, Juciano Gasparotto, Cristiane Matté, José Claudio Fonseca Moreira, Daniel Pens Gelain
The use of dietary supplements to enhance the benefit of exercise training is a common practice. The liver is the organ where all substances are metabolized, and certain supplements have been associated with liver injury. Vitamin A (VA), a liposoluble vitamin stored in the liver, is commonly used as an antioxidant supplement. Here, we evaluated the effect of chronic VA supplementation on oxidative damage and stress parameters in trained rats. Animals were divided into the following groups: sedentary (SE), sedentary/VA (SE+VA), exercise training (ET), and exercise training/VA (ET+VA)...
July 25, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28742932/a-pilot-randomized-clinical-trial-testing-integrated-twelve-step-facilitation-itsf-treatment-for-adolescent-substance-use-disorder
#4
John F Kelly, Yifrah Kaminer, Christopher W Kahler, Bettina Hoeppner, Julie Yeterian, Julie V Cristello, Christine Timko
BACKGROUND AND AIMS: Integration of 12-step philosophy and practices is common in adolescent substance use disorder (SUD) treatment programs, particularly in North America. However, although numerous experimental studies have tested 12-step facilitation (TSF) treatments among adults, no studies have tested TSF-specific treatments for adolescents. We tested the efficacy of a novel integrated TSF. DESIGN: Explanatory, parallel-group, randomized clinical trial comparing 10 sessions of either motivational enhancement therapy/cognitive-behavioral therapy (MET/CBT; n=30) or a novel integrated TSF (iTSF; n=29) with follow-up assessments at 3-, 6-, and 9-months following treatment entry...
July 25, 2017: Addiction
https://www.readbyqxmd.com/read/28742676/committee-opinion-no-711-opioid-use-and-opioid-use-disorder-in-pregnancy
#5
(no author information available yet)
Opioid use in pregnancy has escalated dramatically in recent years, paralleling the epidemic observed in the general population. To combat the opioid epidemic, all health care providers need to take an active role. Pregnancy provides an important opportunity to identify and treat women with substance use disorders. Substance use disorders affect women across all racial and ethnic groups and all socioeconomic groups, and affect women in rural, urban, and suburban populations. Therefore, it is essential that screening be universal...
August 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28742670/committee-opinion-no-711-summary-opioid-use-and-opioid-use-disorder-in-pregnancy
#6
(no author information available yet)
Opioid use in pregnancy has escalated dramatically in recent years, paralleling the epidemic observed in the general population. To combat the opioid epidemic, all health care providers need to take an active role. Pregnancy provides an important opportunity to identify and treat women with substance use disorders. Substance use disorders affect women across all racial and ethnic groups and all socioeconomic groups, and affect women in rural, urban, and suburban populations. Therefore, it is essential that screening be universal...
August 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28742625/online-sales-of-unscheduled-pharmaceutical-agents-a-case-report-of-tianeptine-use-in-the-united-states
#7
Swapnil Gupta, Ryan Wallace, Jordan Sloshower
: Tianeptine is a tricyclic antidepressant that stimulates mu-opioid receptors at high doses. It is marketed and used across Europe and Latin America as an antidepressant, but is not approved by the Food and Drug Administration for use in the United States. In the United States, tianeptine is sold through online health stores as a cognition enhancer, dietary supplement, or as research chemical. We report the case of a 36-year-old man with a history of major depressive disorder, responsive to sertraline, who turned to the unmonitored use of tianeptine purchased online to treat residual feelings of apathy and boredom...
July 24, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28742526/the-black-soldier-fly-hermetia-illucens-a-promising-source-for-sustainable-production-of-proteins-lipids-and-bioactive-substances
#8
Ariane Müller, Diana Wolf, Herwig O Gutzeit
The growing demand worldwide for proteins and lipids cannot be met by the intensive use of agricultural land currently available. Insect mass cultures as a source for proteins and lipids have been in focus for various reasons. An insect with many positive properties is the black soldier fly, Hermetia illucens, whose larvae could be used for the sustainable production of proteins and lipids. Furthermore, the larvae produce bioactive substances which could potentially be used for human and animal welfare.
July 25, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/28742416/comparisons-of-alcohol-and-drug-dependence-in-terms-of-attachments-and-clinical-issues
#9
Dana Zeid, Joshua Carter, Marc A Lindberg
BACKGROUND: Alcohol and drug dependencies are associated with different social stigmas, and some studies suggest they might exhibit different clinical presentations. Further, the treatments for each vary considerably. Alcohol versus drug use problems were compared in terms of attachment patterns and related clinical treatment issues in two interlocking studies using converging logic and designs. METHODS: In Study 1, alcohol versus drug dependence was defined in terms of a known groups design...
July 25, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28742413/association-of-current-and-lifetime-dsm-iv-drug-use-disorder-diagnoses-to-6-month-changes-in-smoking-behavior-in-risky-drinking-smokers-a-pilot-study
#10
Amy Cohn, Sarah Ehlke
BACKGROUND: Alcohol and other drug use disorders co-occur with cigarette smoking and negatively impact cessation outcomes. OBJECTIVES: This study examined the differential effects of current and lifetime DSM-IV drug diagnoses on the 6-month smoking outcomes of 84 untreated heavy drinking smokers who were motivated to quit smoking in the next 6-months. METHODS: Generalized estimating equations (GEE) assessed changes in nicotine dependence, readiness to quit smoking, and prevalence of heavy smoking from baseline to 6-months as a function of time, baseline drinking severity, and drug diagnosis...
July 25, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28742408/risk-competence-in-dealing-with-alcohol-and-other-drugs-in-adolescence
#11
Ede Nagy, Rolf Verres, Dennis Grevenstein
BACKGROUND: Adolescence is a critical phase for the development substance use patterns. We propose that individual competence in dealing with psychoactive substances is crucial for the development of healthy substance use behavior and prevention of substance misuse or addiction. OBJECTIVES: We present a new concept of health related skills in dealing with alcohol and other drugs in adolescence, its operationalization and validation. Our conception of risk competence (RICO) consists of the four major factors being Reflective, Informed, Self-Controlled and Life-Oriented, and their sub-facets...
July 25, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28742256/effect-of-chenopodium-ambrosioides-on-the-healing-process-of-the-in-vivo-bone-tissue
#12
Elizandra Silva da Penha, Rogério Lacerda-Santos, Maria Goretti Freire de Carvalho, Patrícia Teixeira de Oliveira
The focus of this double-blind randomized study was on evaluating the effect of an aqueous extract of Mastruz (Chenopodium ambrosioides L.) on the bone repair process in vivo. In total, 36 male Wistar rats were randomly selected for this study, and divided into 3 groups (n = 12): Group HS (Hemostatic Sponge), Group SM (Hemostatic Sponge with Mastruz) and Group BC (Blood Clot). In each animal, bone defects measuring 2 mm in diameter were performed in both tibias for placement of the substances. After 3 and 10 days, the animals were sacrificed, and the tissues were analyzed under an optical microscope relative to the following events: inflammatory infiltrate; necrosis; young fibroblasts; osteoclastic and osteoblastic activity; endosteal and periosteal bone formation; and bone repair...
July 25, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28741949/ph-dependence-of-%C3%AE-aminobutyric-acid-iontronic-transport
#13
Maria Seitanidou, Juan Felipe Franco-Gonzalez, Theresia Arbring Sjöström, Igor Zozoulenko, Magnus Berggren, Daniel T Simon
The organic electronic ion pump (OEIP) has been developed as an "iontronic" tool for delivery of biological signaling compounds. OEIPs rely on electrophoretically "pumping" charged compounds, either at neutral or shifted pH, through an ion-selective channel. Significant shifts in pH lead to an abundance of H(+) or OH(-), which are delivered along with the intended substance. While this method has been used to transport various neurotransmitters, the role of pH has not been explored. Here we present an investigation of the role of pH on OEIP transport efficiency using the neurotransmitter γ-aminobutyric acid (GABA) as the model cationic delivery substance...
July 25, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28741623/effects-of-suvorexant-a-dual-orexin-hypocretin-receptor-antagonist-on-impulsive-behavior-associated-with-cocaine
#14
Taylor A Gentile, Steven J Simmons, Mia N Watson, Krista L Connelly, Eugen Brailoiu, Yanan Zhang, John W Muschamp
Hypothalamic hypocretin (orexin) peptides mediate arousal, attention, and reward processing. Fibers containing orexins project to brain structures that govern motivated behavior, including the ventral tegmental area (VTA). A number of psychiatric conditions, including attention deficit hyperactivity disorder (ADHD) and substance use disorders, are characterized by deficits in impulse control, however the relationship between orexin and impulsive behavior is incompletely characterized. The effects of systemic or centrally administered orexin receptor (OXR) antagonists on measures of impulsive-like behavior in rats were evaluated using the five-choice serial reaction time task (5-CSRTT) and delay discounting procedures...
July 25, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28741423/cognitive-control-in-young-adults-with-cannabis-use-disorder-an-event-related-brain-potential-study
#15
David Lr Maij, Ben Jm van de Wetering, Ingmar Ha Franken
Contemporary models of substance use disorders emphasize the role of cognitive control, which has been linked to difficulties in resisting the use of substances. In the present study, we measured two aspects of cognitive control, response inhibition (operationalized by a Go/NoGo Task) and performance monitoring (operationalized by an Eriksen Flanker Task), in a group of young cannabis-use disorder (CUD) patients and compared these functions with two control groups (i.e. a group of cigarette smokers and a group of non-smokers)...
July 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28741398/effects-of-role-playing-scenarios-on-the-self-efficacy-of-students-in-resisting-against-substance-addiction-a-pilot-study
#16
Gülnaz Karatay, Nazan Gürarslan Baş
During the first phases of adolescent development, young people have little self-efficacy and resistance against substance use. The aim of this study was to demonstrate the effectiveness of role-playing scenarios on the self-efficacy of students in resisting substance use. A pre test and post test study design was used with a single group. The study was carried out with 245 secondary school students. The scenario-based training, developed by the researchers, was presented by the school counselors once a week for 4 weeks...
January 1, 2017: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://www.readbyqxmd.com/read/28741291/is-personality-associated-with-secondhand-harm-from-drinking
#17
Parnell Davis MacNevin, Kara Thompson, Michael Teehan, Heather Stuart, Sherry Stewart
BACKGROUND: Prior research suggests more than 70% of undergraduates have experienced harm from other students' drinking. This study built on the literature by, first, investigating whether secondhand harm cluster into latent factors that reflect distinct but related types of harm. Second, given the paucity of research examining factors that increase students' vulnerability to secondhand harm, we examined dimensions from Castellanos-Ryan and Conrod's 4-factor personality model for alcohol disorders (impulsivity [IMP], sensation seeking [SS], hopelessness [HOP], anxiety sensitivity [AS]) as predictors of secondhand harm exposure...
July 24, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28741282/reproductive-health-concerns-among-substance-using-women-in-community-corrections-in-new-york-city-understanding-the-role-of-environmental-influences
#18
Anindita Dasgupta, Alissa Davis, Louisa Gilbert, Dawn Goddard-Eckrich, Nabila El-Bassel
Women living in urban settings who are engaged in the criminal justice system are disproportionately affected by HIV and also contend with poor sexual and reproductive health (SRH). While studies have examined environmental influences of HIV, few have examined how these influences relate to poor SRH among this population. We used baseline data from an HIV-risk reduction study among substance-using women with a pregnancy history in community corrections in New York City (N = 299). We examined risk environment factors typically associated with HIV, and SRH outcomes of abortion, and miscarriage...
July 24, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28739294/polycyclic-aromatic-hydrocarbons-and-female-reproductive-health-a-scoping-review
#19
REVIEW
Ashley L Bolden, Johanna R Rochester, Kim Schultz, Carol F Kwiatkowski
Polycyclic aromatic hydrocarbons (PAHs) are a class of common persistent environmental pollutants found in water, air, soil, and plants and can be released by natural sources. However, the majority of atmospheric PAHs are from vehicular emissions, coal-burning plants, and the production and use of petroleum-derived substances. Exposure to PAHs has been implicated in cancer and other diseases, including reproductive disorders. This scoping review is a preliminary step that explores the utility and feasibility of completing a systematic review evaluating the effect of PAHs on female reproduction...
July 21, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28739275/evaluation-of-solvent-systems-for-optimized-extractables-studies-of-single-use-bioprocessing-solutions
#20
Noemí Dorival-García, Jonathan Bones
Despite their advantages, there is concern that single-use systems used in biopharmaceutical manufacture might release potentially toxic substances during standard unit operations that negatively impact cell growth. Characterization of the extractables profile for single-use systems is necessary to know which compounds potentially become leachables under operational cell culture conditions. A key issue in the design of extractables studies is the composition of the model solvent, in particular its pH and polarity...
June 29, 2017: Journal of Chromatography. A
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